FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jorge Capdevila

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Procedures

Disorders

Hypertension

Co-author Network

Publications

TOP 3
Nataliya Pidkovka; Reena Rao; Wen-Hui Wang; Yan Gong; Raymond C Harris; Shaojun Mei; Jorge H Capdevila
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.
Ambra Pozzi; Vlad Popescu; Shilin Yang; Shaojun Mei; Mingjian Shi; Satu M Puolitaival; Richard M Caprioli; Jorge H Capdevila
The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
Shiling Yang; Shouzou Wei; Ambra Pozzi; Jorge H Capdevila
The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jorge Capdevila (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Nataliya Pidkovka; Reena Rao; Wen-Hui Wang; Yan Gong; Raymond C Harris; Shaojun Mei; Jorge H Capdevila
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.
The Journal of biological chemistry 2013;288(7):5223-31.
2010: Ambra Pozzi; Vlad Popescu; Shilin Yang; Shaojun Mei; Mingjian Shi; Satu M Puolitaival; Richard M Caprioli; Jorge H Capdevila
The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
The Journal of biological chemistry 2010;285(17):12840-50.
2009: Shiling Yang; Shouzou Wei; Ambra Pozzi; Jorge H Capdevila
The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.
Archives of biochemistry and biophysics 2009;489(1-2):82-91.
2009: John R Falck; Ravinder Kodela; Rajkumar Manne; Krishnam Raju Atcha; Narender Puli; Narsimhaswamy Dubasi; Vijay L Manthati; Jorge H Capdevila; Xiu-Yu Yi; Daniel H Goldman; Christophe Morisseau; Bruce D Hammock; William B Campbell
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.
Journal of medicinal chemistry 2009;52(16):5069-75.
2009: Raymond Quigley; Sumana Chakravarty; Xueying _ Zhao; John D Imig; Jorge H Capdevila
Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.
Nephron. Physiology 2009;113(4):p23-8.
2008: Jian-Kang Chen; Jianchun Chen; John D Imig; Shouzuo Wei; David L Hachey; Jagadeesh Setti Guthi; John R Falck; Jorge H Capdevila; Raymond C Harris
Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors.
The Journal of biological chemistry 2008;283(36):24514-24.
2008: James V Gainer; Michael Lipkowitz; Chang Yu; Michael R Waterman; Elliott P Dawson; Jorge H Capdevila; Nancy Brown
Association of a CYP4A11 variant and blood pressure in black men.
Journal of the American Society of Nephrology : JASN 2008;19(8):1606-12.
2008: Cheryl L Laffer; James V Gainer; Michael R Waterman; Jorge H Capdevila; Michal Laniado-Schwartzman; Alberto Nasjletti; Nancy Brown; Fernando Elijovich
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.
Hypertension 2008;51(3):767-72.
2008: Ambra Pozzi; Jorge H Capdevila
PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents.
PPAR research 2008;2008():906542.
2007: Jorge H Capdevila
Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases.
Current opinion in nephrology and hypertension 2007;16(5):465-70.
2007: Jorge H Capdevila; John R Falck; J D Imig
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.
Kidney international 2007;72(6):683-9.
2007: Ambra Pozzi; Maria Raquel Ibanez; Arnaldo E Gatica; Shilin Yang; Shouzuo Wei; Shaojun Mei; John R Falck; Jorge H Capdevila
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.
The Journal of biological chemistry 2007;282(24):17685-95.
2007: Jianchun Chen; Jian-Kang Chen; John R Falck; Jagadeesh Setti Guthi; Siddam Anjaiah; Jorge H Capdevila; Raymond C Harris
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite.
Molecular and cellular biology 2007;27(8):3023-34.
2007: John R Falck; Bhavani Sangras; Jorge H Capdevila
Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks.
Bioorganic & medicinal chemistry 2007;15(2):1062-6.
2006: Kiyoshi Nakagawa; Vijaykumar R Holla; Yuan Wei; Wen-Hui Wang; Arnaldo Gatica; Shouzou Wei; Shaojun Mei; Crystal M Miller; Dae Ryong Cha; Edward Price; Roy Zent; Ambra Pozzi; Matthew D Breyer; Youfei Guan; John R Falck; Michael R Waterman; Jorge H Capdevila
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
The Journal of clinical investigation 2006;116(6):1696-702.
2006: Shouzou Wei; James J Brittin; John R Falck; Siddam Anjaiah; Kasem Nithipatikom; Lijie Cui; William B Campbell; Jorge H Capdevila
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.
Analytical biochemistry 2006;352(1):129-34.
2005: Ambra Pozzi; Ines Macias-Perez; Tristin Abair; Shouzuo Wei; Yan Su; Roy Zent; John R Falck; Jorge H Capdevila
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.
The Journal of biological chemistry 2005;280(29):27138-46.
2005: Liping Du; Valery Yermalitsky; Patricia A Ladd; Jorge H Capdevila; Raymond L Mernaugh; Diane S Keeney
Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin.
Archives of biochemistry and biophysics 2005;435(1):125-33.
2005: James V Gainer; Aouatef Bellamine; Elliott P Dawson; Kristie E Womble; Sarah W Grant; Yarong Wang; L Adrienne Cupples; Chao-Yu Guo; Serkalem Demissie; Christopher J O'Donnell; Nancy Brown; Michael R Waterman; Jorge H Capdevila
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
Circulation 2005;111(1):63-9.
2004: Ambra Pozzi; Xuexian Yan; Ines Macias-Perez; Shouzuo Wei; Aaron N Hata; Richard M Breyer; Jason D Morrow; Jorge H Capdevila
Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation.
The Journal of biological chemistry 2004;279(28):29797-804.
2003: Suchismita Mohapatra; Anish Bandyopadhyay; Deb K Barma; Jorge H Capdevila; John R Falck
Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling.
Organic letters 2003;5(25):4759-62.
2003: Deb K Barma; Anish Bandyopadhyay; Jorge H Capdevila; John R Falck
Dimethylthiocarbamate (DMTC): an alcohol protecting group.
Organic letters 2003;5(25):4755-7.
2003: Y Krishna Reddy; L Manmohan Reddy; Jorge H Capdevila; John R Falck
Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity.
Bioorganic & medicinal chemistry letters 2003;13(21):3719-20.
2003: Patricia A Ladd; Liping Du; Jorge H Capdevila; Raymond L Mernaugh; Diane S Keeney
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.
The Journal of biological chemistry 2003;278(37):35184-92.
2003: Kiyoshi Nakagawa; Jackleen S Marji; Michal L Schwartzman; Michael R Waterman; Jorge H Capdevila
Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(4):R1055-62.
2003: Jorge H Capdevila; Kiyoshi Nakagawa; Vijaykumar R Holla
The CYP P450 arachidonate monooxygenases: enzymatic relays for the control of kidney function and blood pressure.
Advances in experimental medicine and biology 2003;525():39-46.
2003: Aouatef Bellamine; Yarong Wang; Michael R Waterman; James V Gainer; Elliott P Dawson; Nancy Brown; Jorge H Capdevila
Characterization of the CYP4A11 gene, a second CYP4A gene in humans.
Archives of biochemistry and biophysics 2003;409(1):221-7.
2002: L Ashley Cowart; Shouzuo Wei; Mei-Hui Hsu; Eric F Johnson; Murali U Krishna; John R Falck; Jorge H Capdevila
The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands.
The Journal of biological chemistry 2002;277(38):35105-12.
2002: Jorge H Capdevila; John R Falck
Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases.
Prostaglandins & other lipid mediators 2002;68-69():325-44.
2002: Jorge H Capdevila; Raymond C Harris; John R Falck
Microsomal cytochrome P450 and eicosanoid metabolism.
Cellular and molecular life sciences : CMLS 2002;59(5):780-9.
2001: Jorge H Capdevila; John R Falck
The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation.
Biochemical and biophysical research communications 2001;285(3):571-6.
2001: Vijaykumar R Holla; F Adas; J D Imig; Xueying _ Zhao; Edward Price; Nancy Olsen; William Kovacs; Mark Magnuson; Diane S Keeney; Matthew D Breyer; John R Falck; Michael R Waterman; Jorge H Capdevila
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5211-6.
2001: L Ashley Cowart; John R Falck; Jorge H Capdevila
Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3.
Archives of biochemistry and biophysics 2001;387(1):117-24.
2000: John R Falck; U Murali Krishna; Jorge H Capdevila
Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2).
Bioorganic & medicinal chemistry letters 2000;10(15):1711-3.
2000: Jorge H Capdevila; John R Falck
Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase.
Prostaglandins & other lipid mediators 2000;62(3):271-92.
2000: christian helvig; Jorge H Capdevila
Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains.
Biochemistry 2000;39(17):5196-205.
2000: Jorge H Capdevila; John R Falck; Raymond C Harris
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.
Journal of lipid research 2000;41(2):163-81.
1999: Vijaykumar R Holla; K Makita; P G Zaphiropoulos; Jorge H Capdevila
The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading.
The Journal of clinical investigation 1999;104(6):751-60.
1999: Jorge H Capdevila; Vijaykumar R Holla; christian helvig; John R Falck
Microsomal cytochrome P450 and eicosanoid metabolism.
Molecular aspects of medicine 1999;20(1-2):42-55, 56-137.
1999: J Chen; Jorge H Capdevila; D C Zeldin; R L Rosenberg
Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids.
Molecular pharmacology 1999;55(2):288-95.
1998: Diane S Keeney; C Skinner; J B Travers; Jorge H Capdevila; Lillian B Nanney; Lloyd E King; Michael R Waterman
Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate monooxygenase activity.
The Journal of biological chemistry 1998;273(48):32071-9.
1998: christian helvig; E Dishman; Jorge H Capdevila
Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3.
Biochemistry 1998;37(36):12546-58.
1997: SE Graham-Lorence; Gilles Truan; Julian A Peterson; John R Falck; S Wei; christian helvig; Jorge H Capdevila
An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase.
The Journal of biological chemistry 1997;272(2):1127-35.
1996: K Makita; John R Falck; Jorge H Capdevila
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(13):1456-63.
1996: Jorge H Capdevila; S Wei; christian helvig; John R Falck; Y Belosludtsev; Gilles Truan; S E Graham-Lorence; Julian A Peterson
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3.
The Journal of biological chemistry 1996;271(37):22663-71.
1995: D C Zeldin; Raymond DuBois; John R Falck; Jorge H Capdevila
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
Archives of biochemistry and biophysics 1995;322(1):76-86.
1995: Alan R Brash; William E Boeglin; Jorge H Capdevila; S Yeola; Ian A Blair
7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement.
Archives of biochemistry and biophysics 1995;321(2):485-92.
1995: Y Sakairi; H R Jacobson; T D Noland; Jorge H Capdevila; John R Falck; Matthew D Breyer
5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis.
The American journal of physiology 1995;268(5 Pt 2):F931-9.
1995: D C Zeldin; J D Plitman; J Kobayashi; R F Miller; JR Snapper; John R Falck; J L Szarek; R M Philpot; Jorge H Capdevila
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.
The Journal of clinical investigation 1995;95(5):2150-60.
1995: Jorge H Capdevila; J D Morrow; Y Y Belosludtsev; D R Beauchamp; Raymond DuBois; John R Falck
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s).
Biochemistry 1995;34(10):3325-37.
1995: D C Zeldin; S Wei; John R Falck; B D Hammock; JR Snapper; Jorge H Capdevila
Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.
Archives of biochemistry and biophysics 1995;316(1):443-51.
1994: K Makita; K Takahashi; A Karara; H R Jacobson; John R Falck; Jorge H Capdevila
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.
The Journal of clinical investigation 1994;94(6):2414-20.
1993: A Karara; K Makita; H R Jacobson; John R Falck; F Peter Guengerich; Raymond DuBois; Jorge H Capdevila
Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase.
The Journal of biological chemistry 1993;268(18):13565-70.
1993: D C Zeldin; J Kobayashi; John R Falck; B S Winder; B D Hammock; JR Snapper; Jorge H Capdevila
Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.
The Journal of biological chemistry 1993;268(9):6402-7.
1993: K Takahashi; Raymond C Harris; Jorge H Capdevila; A Karara; K Makita; H R Jacobson; Karen A Munger; KAMAL BADR
Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration.
Journal of the American Society of Nephrology : JASN 1993;3(8):1496-500.
1992: Jorge H Capdevila; S Wei; A Kumar; J Kobayashi; JR Snapper; D C Zeldin; R K Bhatt; John R Falck
Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography.
Analytical biochemistry 1992;207(2):236-40.
1992: Jorge H Capdevila; S Wei; J Yan; A Karara; H R Jacobson; John R Falck; F Peter Guengerich; Raymond DuBois
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.
The Journal of biological chemistry 1992;267(30):21720-6.
1992: A Karara; S Wei; D Spady; Larry L Swift; Jorge H Capdevila; John R Falck
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.
Biochemical and biophysical research communications 1992;182(3):1320-5.
1992: Jorge H Capdevila; John R Falck; R W Estabrook
Cytochrome P450 and the arachidonate cascade.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):731-6.
1992: H K Jajoo; Jorge H Capdevila; John R Falck; R K Bhatt; Ian A Blair
Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes.
Biochimica et biophysica acta 1992;1123(1):110-6.
1991: A Karara; E Dishman; John R Falck; Jorge H Capdevila
Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties.
The Journal of biological chemistry 1991;266(12):7561-9.
1991: Jorge H Capdevila; E Dishman; A Karara; John R Falck
Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids.
Methods in enzymology 1991;206():441-53.
1990: A Karara; E Dishman; H Jacobson; John R Falck; Jorge H Capdevila
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
FEBS letters 1990;268(1):227-30.
1990: Jorge H Capdevila; A Karara; D J Waxman; M V Martin; John R Falck; F P Guenguerich
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
The Journal of biological chemistry 1990;265(19):10865-71.
1990: John R Falck; S Lumin; I Blair; E Dishman; M V Martin; D J Waxman; F P Guengerich; Jorge H Capdevila
Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.
The Journal of biological chemistry 1990;265(18):10244-9.
1990: Jorge H Capdevila; John R Falck; E Dishman; A Karara
Cytochrome P-450 arachidonate oxygenase.
Methods in enzymology 1990;187():385-94.
1989: A Karara; E Dishman; I Blair; John R Falck; Jorge H Capdevila
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.
The Journal of biological chemistry 1989;264(33):19822-7.
1989: T D Hammonds; Ian A Blair; John R Falck; Jorge H Capdevila
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.
Analytical biochemistry 1989;182(2):300-3.
1988: L Lapuerta; N Chacos; John R Falck; H Jacobson; Jorge H Capdevila
Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.
The American journal of the medical sciences 1988;295(4):275-9.
1988: Jorge H Capdevila; P Mosset; P Yadagiri; S Lumin; John R Falck
NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols.
Archives of biochemistry and biophysics 1988;261(1):122-33.
1987: Jorge H Capdevila; V Kishore; E Dishman; Ian Blair; John R Falck
A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs).
Biochemical and biophysical research communications 1987;146(2):638-44.