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Mario Capecchi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Co-Publications
Name
17
Thomas, Kirk
12
Bernstein, Kenneth
7
Corvol, Pierre
7
Keller, Charles
6
Schmidt, Edward
6
Xiao, Hong
6
Manley, Nancy
5
Arenkiel, Benjamin
5
Fuchs, Sebastien
5
Gaufo, Gary
5
Tvrdik, Petr
4
Moon, Anne
4
Davis, Allan Peter
4
Adams, Jonathan
4
Boulet, Anne

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Publications

TOP 3
Taniguchi Eri; Cho Min Jung; Arenkiel Benjamin R; Hansen Mark S; Rivera Omar J; McCleish Amanda T; Qualman Stephen J; Guttridge Denis C; Scott Matthew P; Capecchi Mario R; Keller Charles
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.
Sangiorgi Eugenio; Capecchi Mario R
Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis.
Haldar Malay; Hedberg Matthew L; Hockin Matthew F; Capecchi Mario R
A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice.

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All Publications

2009: Taniguchi Eri; Cho Min Jung; Arenkiel Benjamin R; Hansen Mark S; Rivera Omar J; McCleish Amanda T; Qualman Stephen J; Guttridge Denis C; Scott Matthew P; Capecchi Mario R; Keller Charles
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.
Pediatric blood & cancer 2009;53(2):136-44.
2009: Sangiorgi Eugenio; Capecchi Mario R
Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7101-6.
2009: Haldar Malay; Hedberg Matthew L; Hockin Matthew F; Capecchi Mario R
A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice.
Cancer research 2009;69(8):3657-64.
2009: Suvorova Elena S; Lucas Olivier; Weisend Carla M; Rollins Maryclare F; Merrill Gary F; Capecchi Mario R; Schmidt Edward E
Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes.
PloS one 2009;4(7):e6158.
2008: Jia Qunshan; McDill Bradley W; Sankarapandian Bala; Wu Sen; Liapis Helen; Holzman Lawrence B; Capecchi Mario R; Miner Jeffrey H; Chen Feng
Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus.
American journal of physiology. Renal physiology 2008;295(6):F1790-8.
2008: Sangiorgi Eugenio; Shuhua Zhang; Capecchi Mario R
In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette.
Nucleic acids research 2008;36(20):e134.
2008: Haldar Malay; Randall R Lor; Capecchi Mario R
Synovial sarcoma: from genetics to genetic-based animal modeling.
Clinical orthopaedics and related research 2008;466(9):2156-67.
2008: Capecchi Mario R
The making of a scientist II (Nobel Lecture).
Chembiochem : a European journal of chemical biology 2008;9(10):1530-43.
2008: Sangiorgi Eugenio; Capecchi Mario R
Bmi1 is expressed in vivo in intestinal stem cells.
Nature genetics 2008;40(7):915-20.
2008: Vasquez Sergio X; Hansen Mark S; Bahadur Ali N; Hockin Matthew F; Kindlmann Gordon L; Nevell Lisa; Wu Isabel Q; Grunwald David J; Weinstein David M; Jones Greg M; Johnson Christopher R; Vandeberg John L; Capecchi Mario R; Keller Charles
Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms.
Anatomical record (Hoboken, N.J. : 2007) 2008;291(5):475-87.
2008: Haldar Malay; Karan Goutam; Tvrdik Petr; Capecchi Mario R
Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.
Developmental cell 2008;14(3):437-45.
2008: Capecchi Mario R
A Nobel lesson: the grant behind the prize. Response.
Science (New York, N.Y.) 2008;319(5865):900-1.
2008: Fuchs Sebastien; Xiao Hong D; Hubert Christine; Michaud Annie; Campbell Duncan J; Adams Jonathan W; Capecchi Mario R; Corvol Pierre; Bernstein Kenneth E
Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo.
Hypertension 2008;51(2):267-74.
2008: Wu Yuanyuan; Wang Guoying; Scott Sheryl A; Capecchi Mario R
Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons.
Development (Cambridge, England) 2008;135(1):171-82.
2008: Wu Sen; Ying Guoxin; Wu Qiang; Capecchi Mario R
A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond.
Nature protocols 2008;3(6):1056-76.
2007: Barrow Jeffery R; Howell William D; Rule Michael; Hayashi Shigemi; Thomas Kirk R; Capecchi Mario R; McMahon Andrew P
Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.
Developmental biology 2007;312(1):312-20.
2007: Bondareva Alla A; Capecchi Mario R; Iverson Sonya V; Li Yan; Lopez Nathan I; Lucas Olivier; Merrill Gary F; Prigge Justin R; Siders Ashley M; Wakamiya Maki; Wallin Stephanie L; Schmidt Edward E
Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.
Free radical biology & medicine 2007;43(6):911-23.
2007: McIntyre Daniel C; Rakshit Sabita; Yallowitz Alisha R; Loken Luke; Jeannotte Lucie; Capecchi Mario R; Wellik Deneen M
Hox patterning of the vertebrate rib cage.
Development (Cambridge, England) 2007;134(16):2981-9.
2007: Wu Sen; Ying Guoxin; Wu Qiang; Capecchi Mario R
Toward simpler and faster genome-wide mutagenesis in mice.
Nature genetics 2007;39(7):922-30.
2007: Shen Xiao Z; Li Ping; Weiss Daiana; Fuchs Sebastien; Xiao Hong D; Adams Jon A; Williams Ifor R; Capecchi Mario R; Taylor W Robert; Bernstein Kenneth E
Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.
The American journal of pathology 2007;170(6):2122-34.
2007: Haldar Malay; Hancock Jeffrey D; Coffin Cheryl M; Lessnick Stephen L; Capecchi Mario R
A conditional mouse model of synovial sarcoma: insights into a myogenic origin.
Cancer cell 2007;11(4):375-88.
2006: Frenzel Kristen; Wallace Tiffany A; McDoom Issam; Xiao Hong D; Capecchi Mario R; Bernstein Kenneth E; Sayeski Peter P
A functional Jak2 tyrosine kinase domain is essential for mouse development.
Experimental cell research 2006;312(15):2735-44.
2006: Tvrdik Petr; Capecchi Mario R
Reversal of Hox1 gene subfunctionalization in the mouse.
Developmental cell 2006;11(2):239-50.
2006: Vorbach Claudia; Capecchi Mario R; Penninger Josef M
Evolution of the mammary gland from the innate immune system?
BioEssays : news and reviews in molecular, cellular and developmental biology 2006;28(6):606-16.
2006: Johnson John T; Hansen Mark S; Wu Isabel; Healy Lindsey J; Johnson Christopher R; Jones Greg M; Capecchi Mario R; Keller Charles
Virtual histology of transgenic mouse embryos for high-throughput phenotyping.
PLoS genetics 2006;2(4):e61.
2006: Wu Sen; Wu Yuanyuan; Capecchi Mario R
Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo.
Development (Cambridge, England) 2006;133(4):581-90.
2006: Westerberg Rolf; Månsson Jan-Erik; Golozoubova Valeria; Shabalina Irina G; Backlund Emma C; Tvrdik Petr; Retterstøl Kjetil; Capecchi Mario R; Jacobsson Anders
ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue.
The Journal of biological chemistry 2006;281(8):4958-68.
2005: Fuchs Sebastien; Frenzel Kristen; Hubert Christine; Lyng Robert; Muller Laurent; Michaud Annie; Xiao Hong D; Adams Jonathan W; Capecchi Mario R; Corvol Pierre; Shur Barry D; Bernstein Kenneth E
Male fertility is dependent on dipeptidase activity of testis ACE.
Nature medicine 2005;11(11):1140-2; author reply 1142-3.
2005: Kindlmann Gordon L; Weinstein David M; Jones Greg M; Johnson Christopher R; Capecchi Mario R; Keller Charles
Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors.
Molecular imaging : official journal of the Society for Molecular Imaging 2005;4(4):417-24.
2005: Keller Charles; Capecchi Mario R
New genetic tactics to model alveolar rhabdomyosarcoma in the mouse.
Cancer research 2005;65(17):7530-2.
2005: Capecchi Mario
An interview with... Mario Capecchi. Interview by Magdalena Skipper.
Nature reviews. Genetics 2005;6(6):434.
2005: Capecchi Mario R
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century.
Nature reviews. Genetics 2005;6(6):507-12.
2005: Schindehütte Jan; Fukumitsu Hidefumi; Collombat Patrick; Griesel Gundula; Brink Christopher; Baier Paul C; Capecchi Mario R; Mansouri Ahmed
In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells.
Stem cells (Dayton, Ohio) 2005;23(1):10-5.
2004: Keller Charles; Hansen Mark S; Coffin Cheryl M; Capecchi Mario R
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.
Genes & development 2004;18(21):2608-13.
2004: Keller Charles; Arenkiel Benjamin R; Coffin Cheryl M; El-Bardeesy Nabeel; DePinho Ronald A; Capecchi Mario R
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Genes & development 2004;18(21):2614-26.
2004: Austin Christopher P; Battey James F; Bradley Allan; Bucan Maja; Capecchi Mario; Collins Francis S; Dove William F; Duyk Geoffrey; Dymecki Susan; Eppig Janan T; Grieder Franziska B; Heintz Nathaniel; Hicks Geoff; Insel Thomas R; Joyner Alexandra; Koller Beverly H; Lloyd K C Kent; Magnuson Terry; Moore Mark W; Nagy Andras; Pollock Jonathan D; Roses Allen D; Sands Arthur T; Seed Brian; Skarnes William C; Snoddy Jay; Soriano Philippe; Stewart David J; Stewart Francis; Stillman Bruce; Varmus Harold; Varticovski Lyuba; Verma Inder M; Vogt Thomas F; von Melchner Harald; Witkowski Jan; Woychik Richard P; Wurst Wolfgang; Yancopoulos George D; Young Stephen G; Zambrowicz Brian
The knockout mouse project.
Nature genetics 2004;36(9):921-4.
2004: Xiao Hong D; Fuchs Sebastien; Campbell Duncan J; Lewis William; Dudley Samuel C; Kasi Vijaykumar S; Hoit Brian D; Keshelava George; Zhao Hui; Capecchi Mario R; Bernstein Kenneth E
Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.
The American journal of pathology 2004;165(3):1019-32.
2004: Boulet Anne M; Moon Anne M; Arenkiel Benjamin R; Capecchi Mario R
The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.
Developmental biology 2004;273(2):361-72.
2004: Arenkiel Benjamin R; Tvrdik Petr; Gaufo Gary O; Capecchi Mario R
Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry.
Genes & development 2004;18(13):1539-52.
2004: Fuchs Sebastien; Xiao Hong D; Cole Justin M; Adams Jonathan W; Frenzel Kristen; Michaud Annie; Zhao Hui; Keshelava George; Capecchi Mario R; Corvol Pierre; Bernstein Kenneth E
Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice.
The Journal of biological chemistry 2004;279(16):15946-53.
2004: Gaufo Gary O; Wu Sen; Capecchi Mario R
Contribution of Hox genes to the diversity of the hindbrain sensory system.
Development (Cambridge, England) 2004;131(6):1259-66.
2004: Westerberg Rolf; Tvrdik Petr; Undén Anne-Birgitte; Månsson Jan-Erik; Norlén Lars; Jakobsson Andreas; Holleran Walter H; Elias Peter M; Asadi Abolfazl; Flodby Per; Toftgård Rune; Capecchi Mario R; Jacobsson Anders
Role for ELOVL3 and fatty acid chain length in development of hair and skin function.
The Journal of biological chemistry 2004;279(7):5621-9.
2004: Boulet Anne M; Capecchi Mario R
Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod.
Development (Cambridge, England) 2004;131(2):299-309.
2004: Wong Kenneth H H; Wintch Heather D; Capecchi Mario R
Hoxa11 regulates stromal cell death and proliferation during neonatal uterine development.
Molecular endocrinology (Baltimore, Md.) 2004;18(1):184-93.
2003: Gaufo Gary O; Thomas Kirk R; Capecchi Mario R
Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons.
Development (Cambridge, England) 2003;130(21):5191-201.
2003: Vorbach Claudia; Harrison Roger; Capecchi Mario R
Xanthine oxidoreductase is central to the evolution and function of the innate immune system.
Trends in immunology 2003;24(9):512-7.
2003: Wellik Deneen M; Capecchi Mario R
Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.
Science (New York, N.Y.) 2003;301(5631):363-7.
2003: Arenkiel Benjamin R; Gaufo Gary O; Capecchi Mario R
Hoxb1 neural crest preferentially form glia of the PNS.
Developmental dynamics : an official publication of the American Association of Anatomists 2003;227(3):379-86.
2003: Economides Kyriakos D; Capecchi Mario R
Hoxb13 is required for normal differentiation and secretory function of the ventral prostate.
Development (Cambridge, England) 2003;130(10):2061-9.
2003: Economides Kyriakos D; Zeltser Lori; Capecchi Mario R
Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae.
Developmental biology 2003;256(2):317-30.
2003: Cole Justin M; Khokhlova Nata; Sutliff Roy L; Adams Jonathan W; Disher Kevin M; Zhao Hui; Capecchi Mario R; Corvol Pierre; Bernstein Kenneth E
Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II.
Hypertension 2003;41(2):313-21.
2003: Barrow Jeffery R; Thomas Kirk R; Boussadia-Zahui Oreda; Moore Robert; Kemler Rolf; Capecchi Mario R; McMahon Andrew P
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
Genes & development 2003;17(3):394-409.
2003: Schmidt Edward E; Bondareva Alla A; Radke Jay R; Capecchi Mario R
Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein.
The Journal of biological chemistry 2003;278(8):6168-74.
2002: Vorbach Claudia; Scriven Alistair; Capecchi Mario R
The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland.
Genes & development 2002;16(24):3223-35.
2002: Frank Deborah U; Fotheringham Lori K; Brewer Judson A; Muglia Louis J; Tristani-Firouzi Martin; Capecchi Mario R; Moon Anne M
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.
Development (Cambridge, England) 2002;129(19):4591-603.
2002: Boulet Anne M; Capecchi Mario R
Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse.
Developmental biology 2002;249(1):96-107.
2002: Hobbs Nicole K; Bondareva Alla A; Barnett Sheila; Capecchi Mario R; Schmidt Edward E
Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system.
Cell 2002;110(1):43-54.
2002: Wellik Deneen M; Hawkes Patrick J; Capecchi Mario R
Hox11 paralogous genes are essential for metanephric kidney induction.
Genes & development 2002;16(11):1423-32.
2002: Cole Justin; Quach Du Le; Sundaram Karthik; Corvol Pierre; Capecchi Mario R; Bernstein Kenneth E
Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure.
Circulation research 2002;90(1):87-92.
2002: Greer Joy M; Capecchi Mario R
Hoxb8 is required for normal grooming behavior in mice.
Neuron 2002;33(1):23-34.
2001: Stadler H S; Higgins K M; Capecchi M R
Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs.
Development (Cambridge, England) 2001;128(21):4177-88.
2001: Capecchi M R
Generating mice with targeted mutations.
Nature medicine 2001;7(10):1086-90.
2001: Manley N R; Barrow J R; Zhang T; Capecchi M R
Hoxb2 and hoxb4 act together to specify ventral body wall formation.
Developmental biology 2001;237(1):130-44.
2000: Cole J; Ertoy D; Lin H; Sutliff R L; Ezan E; Guyene T T; Capecchi M; Corvol P; Bernstein K E
Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice.
The Journal of clinical investigation 2000;106(11):1391-8.
2000: Moon A M; Capecchi M R
Fgf8 is required for outgrowth and patterning of the limbs.
Nature genetics 2000;26(4):455-9.
2000: Schmidt E E; Taylor D S; Prigge J R; Barnett S; Capecchi M R
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13702-7.
2000: Gaufo G O; Flodby P; Capecchi M R
Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.
Development (Cambridge, England) 2000;127(24):5343-54.
2000: Capecchi M R
Choose your target.
Nature genetics 2000;26(2):159-61.
2000: Moon A M; Boulet A M; Capecchi M R
Normal limb development in conditional mutants of Fgf4.
Development (Cambridge, England) 2000;127(5):989-96.
2000: Barrow J R; Stadler H S; Capecchi M R
Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse.
Development (Cambridge, England) 2000;127(5):933-44.
2000: Greer J M; Puetz J; Thomas K R; Capecchi M R
Maintenance of functional equivalence during paralogous Hox gene evolution.
Nature 2000;403(6770):661-5.
2000: Capecchi M R
How close are we to implementing gene targeting in animals other than the mouse?
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):956-7.
1999: Godwin A R; Capecchi M R
Hair defects in Hoxc13 mutant mice.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1999;4(3):244-7.
1999: Hashimoto J; Murakami G; Tsugane M H; Chisaka O; Capecchi M R; Ogino T
Lumbosacral plexus in Hoxa9 knockout mice with special reference to their nerve variations identified according to whether they were interphenotypic or intergenotypic differences.
Kaibogaku zasshi. Journal of anatomy 1999;74(6):609-30.
1999: Rossel M; Capecchi M R
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development.
Development (Cambridge, England) 1999;126(22):5027-40.
1999: Barrow J R; Capecchi M R
Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants.
Development (Cambridge, England) 1999;126(22):5011-26.
1999: Bunting M; Bernstein K E; Greer J M; Capecchi M R; Thomas K R
Targeting genes for self-excision in the germ line.
Genes & development 1999;13(12):1524-8.
1999: Schmidt E E; Hanson E S; Capecchi M R
Sequence-independent assembly of spermatid mRNAs into messenger ribonucleoprotein particles.
Molecular and cellular biology 1999;19(5):3904-15.
1999: Chen F; Capecchi M R
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):541-6.
1998: Godwin A R; Stadler H S; Nakamura K; Capecchi M R
Detection of targeted GFP-Hox gene fusions during mouse embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13042-7.
1998: Chen F; Greer J; Capecchi M R
Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae.
Mechanisms of development 1998;77(1):49-57.
1998: Manley N R; Capecchi M R
Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.
Developmental biology 1998;195(1):1-15.
1998: Hostikka S L; Capecchi M R
The mouse Hoxc11 gene: genomic structure and expression pattern.
Mechanisms of development 1998;70(1-2):133-45.
1998: Godwin A R; Capecchi M R
Hoxc13 mutant mice lack external hair.
Genes & development 1998;12(1):11-20.
1997: Wilder P J; Kelly D; Brigman K; Peterson C L; Nowling T; Gao Q S; McComb R D; Capecchi M R; Rizzino A
Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny.
Developmental biology 1997;192(2):614-29.
1997: Manley N R; Capecchi M R
Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures.
Developmental biology 1997;192(2):274-88.
1997: Carpenter E M; Goddard J M; Davis A P; Nguyen T P; Capecchi M R
Targeted disruption of Hoxd-10 affects mouse hindlimb development.
Development (Cambridge, England) 1997;124(22):4505-14.
1997: Condie B G; Bain G; Gottlieb D I; Capecchi M R
Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11451-5.
1997: Esther C R; Marino E M; Howard T E; Machaud A; Corvol P; Capecchi M R; Bernstein K E
The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.
The Journal of clinical investigation 1997;99(10):2375-85.
1997: Thomas K R; Capecchi M R
Recombinant DNA technique and sickle cell anemia research.
Science (New York, N.Y.) 1997;275(5305):1404-5.
1997: Humphries M M; Rancourt D; Farrar G J; Kenna P; Hazel M; Bush R A; Sieving P A; Sheils D M; McNally N; Creighton P; Erven A; Boros A; Gulya K; Capecchi M R; Humphries P
Retinopathy induced in mice by targeted disruption of the rhodopsin gene.
Nature genetics 1997;15(2):216-9.
1997: Chen F; Capecchi M R
Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions.
Developmental biology 1997;181(2):186-96.
1997: Capecchi M R
Hox genes and mammalian development.
Cold Spring Harbor symposia on quantitative biology 1997;62():273-81.
1996: Barrow J R; Capecchi M R
Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4.
Development (Cambridge, England) 1996;122(12):3817-28.
1996: Esther C R; Howard T E; Zhou Y; Capecchi M R; Marrero M B; Bernstein K E
Lessons from angiotensin-converting enzyme-deficient mice.
Current opinion in nephrology and hypertension 1996;5(6):463-7.
1996: Goddard J M; Rossel M; Manley N R; Capecchi M R
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.
Development (Cambridge, England) 1996;122(10):3217-28.
1996: Boulet A M; Capecchi M R
Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.
Developmental biology 1996;177(1):232-49.
1996: Capecchi M R
Function of homeobox genes in skeletal development.
Annals of the New York Academy of Sciences 1996;785():34-7.
1996: Delort J P; Capecchi M R
TAXI/UAS: A molecular switch to control expression of genes in vivo.
Human gene therapy 1996;7(7):809-20.
1996: Esther C R; Howard T E; Marino E M; Goddard J M; Capecchi M R; Bernstein K E
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.
Laboratory investigation; a journal of technical methods and pathology 1996;74(5):953-65.
1996: Davis A P; Capecchi M R
A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse.
Development (Cambridge, England) 1996;122(4):1175-85.
1995: Zeiher B G; Eichwald E; Zabner J; Smith J J; Puga A P; McCray P B; Capecchi M R; Welsh M J; Thomas K R
A mouse model for the delta F508 allele of cystic fibrosis.
The Journal of clinical investigation 1995;96(4):2051-64.
1995: Manley N R; Capecchi M R
The role of Hoxa-3 in mouse thymus and thyroid development.
Development (Cambridge, England) 1995;121(7):1989-2003.
1995: Davis A P; Witte D P; Hsieh-Li H M; Potter S S; Capecchi M R
Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.
Nature 1995;375(6534):791-5.
1995: Rancourt D E; Tsuzuki T; Capecchi M R
Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.
Genes & development 1995;9(1):108-22.
1994: Spyropoulos D D; Capecchi M R
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.
Genes & development 1994;8(16):1949-61.
1994: Davis A P; Capecchi M R
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11.
Development (Cambridge, England) 1994;120(8):2187-98.
1994: Condie B G; Capecchi M R
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.
Nature 1994;370(6487):304-7.
1994: Kostic D; Capecchi M R
Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column.
Mechanisms of development 1994;46(3):231-47.
1994: Capecchi M R
Targeted gene replacement.
Scientific American 1994;270(3):52-9.
1993: Condie B G; Capecchi M R
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis.
Development (Cambridge, England) 1993;119(3):579-95.
1993: Carpenter E M; Goddard J M; Chisaka O; Manley N R; Capecchi M R
Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain.
Development (Cambridge, England) 1993;118(4):1063-75.
1993: Deng C; Thomas K R; Capecchi M R
Location of crossovers during gene targeting with insertion and replacement vectors.
Molecular and cellular biology 1993;13(4):2134-40.
1993: Capecchi M R
Mouse genetics. YACs to the rescue.
Nature 1993;362(6417):205-6.
1993: Mansour S L; Goddard J M; Capecchi M R
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear.
Development (Cambridge, England) 1993;117(1):13-28.
1992: Deng C; Capecchi M R
Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.
Molecular and cellular biology 1992;12(8):3365-71.
1992: Thomas K R; Deng C; Capecchi M R
High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors.
Molecular and cellular biology 1992;12(7):2919-23.
1992: Chisaka O; Musci T S; Capecchi M R
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.
Nature 1992;355(6360):516-20.
1991: Thomas K R; Musci T S; Neumann P E; Capecchi M R
Swaying is a mutant allele of the proto-oncogene Wnt-1.
Cell 1991;67(5):969-76.
1991: Chisaka O; Capecchi M R
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.
Nature 1991;350(6318):473-9.
1990: Capecchi M
Gene targeting. How efficient can you get?
Nature 1990;348(6297):109.
1990: Mansour S L; Thomas K R; Deng C X; Capecchi M R
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7688-92.
1990: Thomas K R; Capecchi M R
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.
Nature 1990;346(6287):847-50.
1990: Capecchi M
Gene targeting: tapping the cellular telephone.
Nature 1990;344(6262):105.
1989: Capecchi M R
Altering the genome by homologous recombination.
Science (New York, N.Y.) 1989;244(4910):1288-92.
1989: Capecchi M R
The new mouse genetics: altering the genome by gene targeting.
Trends in genetics : TIG 1989;5(3):70-6.
1988: Mansour S L; Thomas K R; Capecchi M R
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes.
Nature 1988;336(6197):348-52.
1987: Thomas K R; Capecchi M R
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
Cell 1987;51(3):503-12.
1987: Wong E A; Capecchi M R
Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase.
Molecular and cellular biology 1987;7(6):2294-5.
1986: Thomas K R; Capecchi M R
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.
Nature 1986;324(6092):34-8.
1986: Goddard J M; Weiland J J; Capecchi M R
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2172-6.
1986: Thomas K R; Folger K R; Capecchi M R
High frequency targeting of genes to specific sites in the mammalian genome.
Cell 1986;44(3):419-28.
1986: Wong E A; Capecchi M R
Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays.
Somatic cell and molecular genetics 1986;12(1):63-72.
1986: Thomas K R; Capecchi M R
Targeting of genes to specific sites in the mammalian genome.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():1101-13.
1985: Frels W I; Bluestone J A; Hodes R J; Capecchi M R; Singer D S
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.
Science (New York, N.Y.) 1985;228(4699):577-80.
1985: Folger K R; Thomas K; Capecchi M R
Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.
Molecular and cellular biology 1985;5(1):70-4.
1985: Wong E A; Capecchi M R
Effect of cell cycle position on transformation by microinjection.
Somatic cell and molecular genetics 1985;11(1):43-51.
1985: Folger K R; Thomas K; Capecchi M R
Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei.
Molecular and cellular biology 1985;5(1):59-69.
1984: Laski F A; Belagaje R; Hudziak R M; Capecchi M R; Norton G P; Palese P; RajBhandary U L; Sharp P A
Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells.
The EMBO journal 1984;3(11):2445-52.
1984: Folger K; Thomas K; Capecchi M R
Analysis of homologous recombination in cultured mammalian cells.
Cold Spring Harbor symposia on quantitative biology 1984;49():123-38.
1983: Young J F; Capecchi M; Laski F A; RajBhandary U L; Sharp P A; Palese P
Measurement of suppressor transfer RNA activity.
Science (New York, N.Y.) 1983;221(4613):873-5.
1983: Luciw P A; Bishop J M; Varmus H E; Capecchi M R
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.
Cell 1983;33(3):705-16.
1982: Hudziak R M; Laski F A; RajBhandary U L; Sharp P A; Capecchi M R
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes.
Cell 1982;31(1):137-46.
1982: Folger K R; Wong E A; Wahl G; Capecchi M R
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.
Molecular and cellular biology 1982;2(11):1372-87.
1980: Capecchi M R
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells.
Cell 1980;22(2 Pt 2):479-88.
1977: Capecchi M R; Haar R A; Capecchi N E; Sveda M M
The isolation of a suppressible nonsense mutant in mammalian cells.
Cell 1977;12(2):371-81.
1975: Capecchi M R; Hughes S H; Wahl G M
Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro.
Cell 1975;6(3):269-77.
1975: Wahl G M; Hughes S H; Capecchi M R
Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene.
Journal of cellular physiology 1975;85(2 Pt 1):307-20.
1975: Hughes S H; Wahl G M; Capecchi M R
Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase.
The Journal of biological chemistry 1975;250(1):120-6.
1974: Capecchi M R; Capecchi N E; Hughes S H; Wahl G M
Selective degradation of abnormal proteins in mammalian tissue culture cells.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(12):4732-6.
1973: Sharp J D; Capecchi N E; Capecchi M R
Altered enzymes in drug-resistant variants of mammalian tissue culture cells.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(11):3145-9.
1971: Klein H; Capecchi M R
Polypetide chain termination. Purification of the release factors, R1 and R2, from Escherichia coli.
The Journal of biological chemistry 1971;246(4):1055-61.
1970: Capecchi M R; Klein H A
Release factors mediating termination of complete proteins.
Nature 1970;226(5250):1029-33.
1969: Capecchi M R; Klein H A
Characterization of three proteins involved in polypeptide chain termination.
Cold Spring Harbor symposia on quantitative biology 1969;34():469-77.
1967: Capecchi M R
Polarity in vitro.
Journal of molecular biology 1967;30(1):213-7.
1967: Capecchi M R
A rapid assay for polypeptide chain termination.
Biochemical and biophysical research communications 1967;28(5):773-8.
1967: Capecchi M R
Polypeptide chain termination in vitro: isolation of a release factor.
Proceedings of the National Academy of Sciences of the United States of America 1967;58(3):1144-51.
1966: Capecchi M R
Cell-free protein synthesis programmed with R17 RNA: identification of two phage proteins.
Journal of molecular biology 1966;21(1):173-93.
1966: Bergquist P L; Capecchi M R
Fractionation of a suppressor sRNA.
Journal of molecular biology 1966;19(1):202-6.
1966: Capecchi M R
Initiation of E. coli proteins.
Proceedings of the National Academy of Sciences of the United States of America 1966;55(6):1517-24.
1966: Adams J M; Capecchi M R
N-formylmethionyl-sRNA as the initiator of protein synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1966;55(1):147-55.
1966: Gussin G N; Capecchi M R; Adams J M; Argetsinger J E; Tooze J; Weber K; Watson J D
Protein synthesis directed by DNA phage messengers.
Cold Spring Harbor symposia on quantitative biology 1966;31():157-71.

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