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Mario Capecchi

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TOP 3
K B Jones; C Lenz; T O Nielsen; R Lor Randall; S Sharma; L Su; T M Underhill; H Jin; Mario R Capecchi
SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas.
Kevin B Jones; Elizabeth Jurrus; Sandhya Ravichandran; Ross Whitaker; Manasi Datar; Huifeng Jin; Mario R Capecchi
Toward an understanding of the short bone phenotype associated with multiple osteochondromas.
Krystal M Straessler; Matt van de Rijn; Hao Hu; Huifeng Jin; Kevin B Jones; Mario R Capecchi
Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics.

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All Publications

2013: K B Jones; C Lenz; T O Nielsen; R Lor Randall; S Sharma; L Su; T M Underhill; H Jin; Mario R Capecchi
SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas.
Oncogene 2013;32(18):2365-71.
2013: Kevin B Jones; Elizabeth Jurrus; Sandhya Ravichandran; Ross Whitaker; Manasi Datar; Huifeng Jin; Mario R Capecchi
Toward an understanding of the short bone phenotype associated with multiple osteochondromas.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013;31(4):651-7.
2013: Krystal M Straessler; Matt van de Rijn; Hao Hu; Huifeng Jin; Kevin B Jones; Mario R Capecchi
Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics.
Cancer cell 2013;23(2):215-27.
2013: Lorise C Gahring; Todd W Kelley; Elizabeth J Myers; Mario R Capecchi; Olga V Efimova; Elena Y Enioutina; Gerald J Spangrude; Petr Tvrdik; Scott W Rogers
Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage.
PloS one 2013;8(3):e57481.
2012: Anne M Boulet; Mario R Capecchi
Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo.
Developmental biology 2012;371(2):235-45.
2012: Scott W Rogers; Petr Tvrdik; Mario R Capecchi; Lorise C Gahring
Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure.
American journal of medical genetics. Part A 2012;158A(5):1135-44.
2012: Justin R Prigge; Elias Arnér; Mario R Capecchi; Sofi Eriksson; Sonya V Iverson; Tesia A Meade; Edward E Schmidt
Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.
Free radical biology & medicine 2012;52(4):803-10.
2011: Hill Melinda; Kathryn M Elbert; Julio Hidalgo; Mario R Capecchi
T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):4914-9.
2011: Brian P Rubin; Koichi Nishijo; Hung-I Harry Chen; Xiaolan Yi; David P Schuetze; Ranadip Pal; Suresh Prajapati; Jinu Abraham; Benjamin R Arenkiel; Qing-Rong Chen; Sean Davis; Amanda T McCleish; Mario R Capecchi; Joel Michalek; Lee Ann Zarzabal; Javed Khan; Zhongxin Yu; David M Parham; Frederic G Barr; Paul S Meltzer; Yidong Chen; Charles Keller
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma.
Cancer cell 2011;19(2):177-91.
2011: Damir Zadravec; Petr Tvrdik; Hervé Guillou; Richard Haslam; Tsutomu Kobayashi; Johnathan A Napier; Mario R Capecchi; Anders Jacobsson
ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice.
Journal of lipid research 2011;52(2):245-55.
2010: MaryClare F Rollins; Dana M van der Heide; Carla M Weisend; Jean A Kundert; Kristin M Comstock; Elena S Suvorova; Mario R Capecchi; Gary F Merrill; Edward E Schmidt
Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration.
Journal of cell science 2010;123(Pt 14):2402-12.
2010: Shau-Kwaun Chen; Petr Tvrdik; Erik Peden; Scott Cho; Sen Wu; Gerald J Spangrude; Mario R Capecchi
Hematopoietic origin of pathological grooming in Hoxb8 mutant mice.
Cell 2010;141(5):775-85.
2010: Nadja Makki; Mario R Capecchi
Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere.
Developmental biology 2010;341(2):499-509.
2010: Piyush Tripathi; Qiusha Guo; Yinqiu Wang; Matthew Coussens; Helen Liapis; Sanjay Jain; Michael R Kuehn; Mario R Capecchi; Feng Chen
Midline signaling regulates kidney positioning but not nephrogenesis through Shh.
Developmental biology 2010;340(2):518-27.
2010: Kevin B Jones; Virginia Piombo; Charles Searby; Gail Kurriger; Baoli Yang; Florian Grabellus; Peter J Roughley; Jose A Morcuende; Joseph A Buckwalter; Mario R Capecchi; Andrea Vortkamp; Val C Sheffield
A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2054-9.
2009: Eri Taniguchi; Min Jung Cho; Benjamin R Arenkiel; Mark S Hansen; Omar J Rivera; Amanda T McCleish; Stephen J Qualman; Denis C Guttridge; Matthew P Scott; Mario R Capecchi; Charles Keller
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.
Pediatric blood & cancer 2009;53(2):136-44.
2009: Eugenio Sangiorgi; Mario R Capecchi
Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7101-6.
2009: Malay Haldar; Matthew L Hedberg; Matthew F Hockin; Mario R Capecchi
A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice.
Cancer research 2009;69(8):3657-64.
2009: Elena S Suvorova; Olivier Lucas; Carla M Weisend; Maryclare F Rollins; Gary F Merrill; Mario R Capecchi; Edward E Schmidt
Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes.
PloS one 2009;4(7):e6158.
2008: Qunshan Jia; Bradley W McDill; Bala Sankarapandian; Sen Wu; Helen Liapis; Lawrence B Holzman; Mario R Capecchi; Jeffrey H Miner; Feng Chen
Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus.
American journal of physiology. Renal physiology 2008;295(6):F1790-8.
2008: Eugenio Sangiorgi; Zhang Shuhua; Mario R Capecchi
In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette.
Nucleic acids research 2008;36(20):e134.
2008: Malay Haldar; R Lor Randall; Mario R Capecchi
Synovial sarcoma: from genetics to genetic-based animal modeling.
Clinical orthopaedics and related research 2008;466(9):2156-67.
2008: Mario R Capecchi
The making of a scientist II (Nobel Lecture).
Chembiochem : a European journal of chemical biology 2008;9(10):1530-43.
2008: Eugenio Sangiorgi; Mario R Capecchi
Bmi1 is expressed in vivo in intestinal stem cells.
Nature genetics 2008;40(7):915-20.
2008: Sergio Vasquez; Mark S Hansen; Ali N Bahadur; Matthew F Hockin; Gordon L Kindlmann; Lisa Nevell; Isabel Q Wu; David J Grunwald; David M Weinstein; Greg M Jones; Christopher R Johnson; John VandeBerg; Mario R Capecchi; Charles Keller
Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms.
Anatomical record (Hoboken, N.J. : 2007) 2008;291(5):475-87.
2008: Malay Haldar; Goutam Karan; Petr Tvrdik; Mario R Capecchi
Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.
Developmental cell 2008;14(3):437-45.
2008: Mario R Capecchi
A Nobel lesson: the grant behind the prize. Response.
Science (New York, N.Y.) 2008;319(5865):900-1.
2008: Sebastien Fuchs; Hong D Xiao; Christine Hubert; Annie Michaud; Duncan John Campbell; Jonathan W Adams; Mario R Capecchi; Pierre Corvol; Kenneth E Bernstein
Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo.
Hypertension 2008;51(2):267-74.
2008: Sen Wu; Guoxin Ying; Qiang Wu; Mario R Capecchi
A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond.
Nature protocols 2008;3(6):1056-76.
2008: Yuanyuan Wu; Guoying Wang; Sheryl A Scott; Mario R Capecchi
Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons.
Development (Cambridge, England) 2008;135(1):171-82.
2007: Jeffery R Barrow; William D Howell; Michael Rule; Shigemi Hayashi; Kirk R Thomas; Mario R Capecchi; Andrew P McMahon
Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.
Developmental biology 2007;312(1):312-20.
2007: Alla A Bondareva; Mario R Capecchi; Sonya V Iverson; Yan Li; nathan ian lopez; Olivier Lucas; Gary F Merrill; Justin R Prigge; Ashley M Siders; Maki Wakamiya; Stephanie L Wallin; Edward E Schmidt
Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.
Free radical biology & medicine 2007;43(6):911-23.
2007: Daniel C McIntyre; Sabita Rakshit; Alisha R Yallowitz; Luke Loken; Lucie Jeannotte; Mario R Capecchi; Deneen M Wellik
Hox patterning of the vertebrate rib cage.
Development (Cambridge, England) 2007;134(16):2981-9.
2007: Sen Wu; Guoxin Ying; Qiang Wu; Mario R Capecchi
Toward simpler and faster genome-wide mutagenesis in mice.
Nature genetics 2007;39(7):922-30.
2007: Xiao Z Shen; Ping Li; Daiana Weiss; Sebastien Fuchs; Hong D Xiao; Jon A Adams; Ifor Williams; Mario R Capecchi; W. Robert Taylor; Kenneth E Bernstein
Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.
The American journal of pathology 2007;170(6):2122-34.
2007: Malay Haldar; Jeffrey D Hancock; Cheryl M Coffin; Stephen L Lessnick; Mario R Capecchi
A conditional mouse model of synovial sarcoma: insights into a myogenic origin.
Cancer cell 2007;11(4):375-88.
2006: Kristen Frenzel; Tiffany A Wallace; Issam McDoom; Hong D Xiao; Mario R Capecchi; Kenneth E Bernstein; Peter P Sayeski
A functional Jak2 tyrosine kinase domain is essential for mouse development.
Experimental cell research 2006;312(15):2735-44.
2006: Petr Tvrdik; Mario R Capecchi
Reversal of Hox1 gene subfunctionalization in the mouse.
Developmental cell 2006;11(2):239-50.
2006: Claudia Vorbach; Mario R Capecchi; Josef M Penninger
Evolution of the mammary gland from the innate immune system?
BioEssays : news and reviews in molecular, cellular and developmental biology 2006;28(6):606-16.
2006: John T Johnson; Mark S Hansen; Isabel Wu; Lindsey J Healy; Christopher R Johnson; Greg M Jones; Mario R Capecchi; Charles Keller
Virtual histology of transgenic mouse embryos for high-throughput phenotyping.
PLoS genetics 2006;2(4):e61.
2006: Rolf Westerberg; Jan-Erik Månsson; Valeria Golozoubova; Irina Shabalina; Emma C Backlund; Petr Tvrdik; Kjetil Retterstøl; Mario R Capecchi; Anders Jacobsson
ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue.
The Journal of biological chemistry 2006;281(8):4958-68.
2006: Sen Wu; Yuanyuan Wu; Mario R Capecchi
Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo.
Development (Cambridge, England) 2006;133(4):581-90.
2005: Sebastien Fuchs; Kristen Frenzel; Christine Hubert; Robert Lyng; Laurent Muller; Annie Michaud; Hong D Xiao; Jonathan W Adams; Mario R Capecchi; Pierre Corvol; Barry D Shur; Kenneth E Bernstein
Male fertility is dependent on dipeptidase activity of testis ACE.
Nature medicine 2005;11(11):1140-2; author reply 1142-3.
2005: Gordon L Kindlmann; David M Weinstein; Greg M Jones; Christopher R Johnson; Mario R Capecchi; Charles Keller
Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors.
Molecular imaging 2005;4(4):417-24.
2005: Charles Keller; Mario R Capecchi
New genetic tactics to model alveolar rhabdomyosarcoma in the mouse.
Cancer research 2005;65(17):7530-2.
2005: Mario R Capecchi
An interview with... Mario Capecchi. Interview by Magdalena Skipper.
Nature reviews. Genetics 2005;6(6):434.
2005: Mario R Capecchi
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century.
Nature reviews. Genetics 2005;6(6):507-12.
2005: Jan Schindehütte; Hidefumi Fukumitsu; Patrick Collombat; Gundula Griesel; Christopher Brink; Paul Christian Baier; Mario R Capecchi; Ahmed Mansouri
In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells.
Stem cells (Dayton, Ohio) 2005;23(1):10-5.
2004: Charles Keller; Mark S Hansen; Cheryl M Coffin; Mario R Capecchi
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.
Genes & development 2004;18(21):2608-13.
2004: Charles Keller; Benjamin R Arenkiel; Cheryl M Coffin; Nabeel El-Bardeesy; Ronald A DePinho; Mario R Capecchi
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Genes & development 2004;18(21):2614-26.
2004: Anne M Boulet; Anne M Moon; Benjamin R Arenkiel; Mario R Capecchi
The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.
Developmental biology 2004;273(2):361-72.
2004: Christopher P Austin; James F Battey; Allan Bradley; Maja Bucan; Mario R Capecchi; Francis S Collins; William F Dove; Geoffrey Duyk; Susan Dymecki; Janan T Eppig; Franziska B Grieder; Nathaniel Heintz; Geoff Hicks; Thomas R Insel; Alexandra L Joyner; Beverly H Koller; K C Kent Lloyd; Terry Magnuson; Mark W Moore; Andras Nagy; Jonathan D Pollock; Allen D Roses; Arthur T Sands; Brian Seed; William C Skarnes; Jay Snoddy; Philippe Soriano; David J Stewart; Francis Stewart; Bruce Stillman; Harold Varmus; Lyuba Varticovski; Inder M Verma; Thomas F Vogt; Harald von Melchner; Jan Witkowski; Richard P Woychik; Wolfgang Wurst; George D Yancopoulos; Stephen G Young; Brian Zambrowicz
The knockout mouse project.
Nature genetics 2004;36(9):921-4.
2004: Hong D Xiao; Sebastien Fuchs; Duncan John Campbell; William Lewis; Samuel C Dudley; Vijaykumar S Kasi; Brian D Hoit; George Keshelava; Hui Zhao; Mario R Capecchi; Kenneth E Bernstein
Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.
The American journal of pathology 2004;165(3):1019-32.
2004: Benjamin R Arenkiel; Petr Tvrdik; Gary O Gaufo; Mario R Capecchi
Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry.
Genes & development 2004;18(13):1539-52.
2004: Sebastien Fuchs; Hong D Xiao; Justin M Cole; Jonathan W Adams; Kristen Frenzel; Annie Michaud; Hui Zhao; George Keshelava; Mario R Capecchi; Pierre Corvol; Kenneth E Bernstein
Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice.
The Journal of biological chemistry 2004;279(16):15946-53.
2004: Gary O Gaufo; Sen Wu; Mario R Capecchi
Contribution of Hox genes to the diversity of the hindbrain sensory system.
Development (Cambridge, England) 2004;131(6):1259-66.
2004: Rolf Westerberg; Petr Tvrdik; Anne Birgitte Undén; Jan-Erik Månsson; Lars Norlén; Andreas Jakobsson; Walter H Holleran; Peter M Elias; Abolfazl Asadi; Per Flodby; Rune Toftgård; Mario R Capecchi; Anders Jacobsson
Role for ELOVL3 and fatty acid chain length in development of hair and skin function.
The Journal of biological chemistry 2004;279(7):5621-9.
2004: Anne M Boulet; Mario R Capecchi
Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod.
Development (Cambridge, England) 2004;131(2):299-309.
2004: Kenneth H H Wong; Heather D Wintch; Mario R Capecchi
Hoxa11 regulates stromal cell death and proliferation during neonatal uterine development.
Molecular endocrinology (Baltimore, Md.) 2004;18(1):184-93.
2003: Gary O Gaufo; Kirk R Thomas; Mario R Capecchi
Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons.
Development (Cambridge, England) 2003;130(21):5191-201.
2003: Claudia Vorbach; Roger Harrison; Mario R Capecchi
Xanthine oxidoreductase is central to the evolution and function of the innate immune system.
Trends in immunology 2003;24(9):512-7.
2003: Deneen M Wellik; Mario R Capecchi
Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.
Science (New York, N.Y.) 2003;301(5631):363-7.
2003: Benjamin R Arenkiel; Gary O Gaufo; Mario R Capecchi
Hoxb1 neural crest preferentially form glia of the PNS.
Developmental dynamics : an official publication of the American Association of Anatomists 2003;227(3):379-86.
2003: Kyriakos D Economides; Mario R Capecchi
Hoxb13 is required for normal differentiation and secretory function of the ventral prostate.
Development (Cambridge, England) 2003;130(10):2061-9.
2003: Kyriakos D Economides; Lori Zeltser; Mario R Capecchi
Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae.
Developmental biology 2003;256(2):317-30.
2003: Edward E Schmidt; Alla A Bondareva; Jay R Radke; Mario R Capecchi
Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein.
The Journal of biological chemistry 2003;278(8):6168-74.
2003: Justin M Cole; Nata Khokhlova; Roy L Sutliff; Jonathan W Adams; Kevin M Disher; Hui Zhao; Mario R Capecchi; Pierre Corvol; Kenneth E Bernstein
Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II.
Hypertension 2003;41(2):313-21.
2003: Jeffery R Barrow; Kirk R Thomas; Oreda Boussadia-Zahui; Robert Moore; Rolf Kemler; Mario R Capecchi; Andrew P McMahon
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
Genes & development 2003;17(3):394-409.
2002: Claudia Vorbach; Alistair Scriven; Mario R Capecchi
The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland.
Genes & development 2002;16(24):3223-35.
2002: Deborah U Frank; Lori K Fotheringham; Judson Brewer; Louis J Muglia; Martin Tristani-Firouzi; Mario R Capecchi; Anne M Moon
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.
Development (Cambridge, England) 2002;129(19):4591-603.
2002: Anne M Boulet; Mario R Capecchi
Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse.
Developmental biology 2002;249(1):96-107.
2002: Nicole K Hobbs; Alla A Bondareva; Sheila Barnett; Mario R Capecchi; Edward E Schmidt
Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system.
Cell 2002;110(1):43-54.
2002: Deneen M Wellik; Patrick J Hawkes; Mario R Capecchi
Hox11 paralogous genes are essential for metanephric kidney induction.
Genes & development 2002;16(11):1423-32.
2002: Justin Cole; Du Le Quach; Karthik Sundaram; Pierre Corvol; Mario R Capecchi; Kenneth E Bernstein
Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure.
Circulation research 2002;90(1):87-92.
2002: Joy M Greer; Mario R Capecchi
Hoxb8 is required for normal grooming behavior in mice.
Neuron 2002;33(1):23-34.
2001: HS Stadler; K M Higgins; Mario R Capecchi
Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs.
Development (Cambridge, England) 2001;128(21):4177-88.
2001: Mario R Capecchi
Generating mice with targeted mutations.
Nature medicine 2001;7(10):1086-90.
2001: Nancy R Manley; J R Barrow; T Zhang; Mario R Capecchi
Hoxb2 and hoxb4 act together to specify ventral body wall formation.
Developmental biology 2001;237(1):130-44.
2000: Edward E Schmidt; D S Taylor; Justin R Prigge; S Barnett; Mario R Capecchi
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13702-7.
2000: Justin Cole; D Ertoy; H Lin; Roy L Sutliff; E Ezan; Than-Tam Guyene; Mario R Capecchi; Pierre Corvol; Kenneth E Bernstein
Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice.
The Journal of clinical investigation 2000;106(11):1391-8.
2000: Anne M Moon; Mario R Capecchi
Fgf8 is required for outgrowth and patterning of the limbs.
Nature genetics 2000;26(4):455-9.
2000: Gary O Gaufo; Per Flodby; Mario R Capecchi
Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.
Development (Cambridge, England) 2000;127(24):5343-54.
2000: Mario R Capecchi
Choose your target.
Nature genetics 2000;26(2):159-61.
2000: Anne M Moon; Anne M Boulet; Mario R Capecchi
Normal limb development in conditional mutants of Fgf4.
Development (Cambridge, England) 2000;127(5):989-96.
2000: J R Barrow; HS Stadler; Mario R Capecchi
Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse.
Development (Cambridge, England) 2000;127(5):933-44.
2000: Joy M Greer; J Puetz; Kirk R Thomas; Mario R Capecchi
Maintenance of functional equivalence during paralogous Hox gene evolution.
Nature 2000;403(6770):661-5.
2000: Mario R Capecchi
How close are we to implementing gene targeting in animals other than the mouse?
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):956-7.
1999: AR Godwin; Mario R Capecchi
Hair defects in Hoxc13 mutant mice.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1999;4(3):244-7.
1999: J Hashimoto; Gen Murakami; M H Tsugane; O Chisaka; Mario R Capecchi; T Ogino
Lumbosacral plexus in Hoxa9 knockout mice with special reference to their nerve variations identified according to whether they were interphenotypic or intergenotypic differences.
Kaibogaku zasshi. Journal of anatomy 1999;74(6):609-30.
1999: M Rossel; Mario R Capecchi
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development.
Development (Cambridge, England) 1999;126(22):5027-40.
1999: J R Barrow; Mario R Capecchi
Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants.
Development (Cambridge, England) 1999;126(22):5011-26.
1999: Michaeline Bunting; K E Bernstein; Joy M Greer; Mario R Capecchi; Kirk R Thomas
Targeting genes for self-excision in the germ line.
Genes & development 1999;13(12):1524-8.
1999: Edward E Schmidt; E S Hanson; Mario R Capecchi
Sequence-independent assembly of spermatid mRNAs into messenger ribonucleoprotein particles.
Molecular and cellular biology 1999;19(5):3904-15.
1999: F Chen; Mario R Capecchi
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):541-6.
1998: AR Godwin; HS Stadler; K Nakamura; Mario R Capecchi
Detection of targeted GFP-Hox gene fusions during mouse embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13042-7.
1998: F Chen; J Greer; Mario R Capecchi
Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae.
Mechanisms of development 1998;77(1):49-57.
1998: Nancy R Manley; Mario R Capecchi
Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.
Developmental biology 1998;195(1):1-15.
1998: S L Hostikka; Mario R Capecchi
The mouse Hoxc11 gene: genomic structure and expression pattern.
Mechanisms of development 1998;70(1-2):133-45.
1998: AR Godwin; Mario R Capecchi
Hoxc13 mutant mice lack external hair.
Genes & development 1998;12(1):11-20.
1997: Phillip J Wilder; D Kelly; K Brigman; C L Peterson; Tamara Nowling; Q S Gao; Rodney D McComb; Mario R Capecchi; Angie Rizzino
Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny.
Developmental biology 1997;192(2):614-29.
1997: Nancy R Manley; Mario R Capecchi
Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures.
Developmental biology 1997;192(2):274-88.
1997: Ellen M Carpenter; J M Goddard; Allan Peter Davis; T P Nguyen; Mario R Capecchi
Targeted disruption of Hoxd-10 affects mouse hindlimb development.
Development (Cambridge, England) 1997;124(22):4505-14.
1997: Brian G Condie; G Bain; David I Gottlieb; Mario R Capecchi
Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11451-5.
1997: Charles R Esther; E M Marino; Tom E Howard; A Machaud; Pierre Corvol; Mario R Capecchi; Kenneth E Bernstein
The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.
The Journal of clinical investigation 1997;99(10):2375-85.
1997: Kirk R Thomas; Mario R Capecchi
Recombinant DNA technique and sickle cell anemia research.
Science (New York, N.Y.) 1997;275(5305):1404-5.
1997: Marian Humphries; D Rancourt; G Jane Farrar; Paul F Kenna; M Hazel; Ronald A Bush; Paul Sieving; D M Sheils; Niamh McNally; P Creighton; A Erven; A Boros; Karoly Gulya; Mario R Capecchi; Peter Humphries
Retinopathy induced in mice by targeted disruption of the rhodopsin gene.
Nature genetics 1997;15(2):216-9.
1997: F Chen; Mario R Capecchi
Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions.
Developmental biology 1997;181(2):186-96.
1997: Mario R Capecchi
Hox genes and mammalian development.
Cold Spring Harbor symposia on quantitative biology 1997;62():273-81.
1996: J R Barrow; Mario R Capecchi
Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4.
Development (Cambridge, England) 1996;122(12):3817-28.
1996: Charles R Esther; Tom E Howard; Y Zhou; Mario R Capecchi; Mario B Marrero; Kenneth E Bernstein
Lessons from angiotensin-converting enzyme-deficient mice.
Current opinion in nephrology and hypertension 1996;5(6):463-7.
1996: J M Goddard; M Rossel; Nancy R Manley; Mario R Capecchi
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.
Development (Cambridge, England) 1996;122(10):3217-28.
1996: A M Boulet; Mario R Capecchi
Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.
Developmental biology 1996;177(1):232-49.
1996: Mario R Capecchi
Function of homeobox genes in skeletal development.
Annals of the New York Academy of Sciences 1996;785():34-7.
1996: Jacques Delort; Mario R Capecchi
TAXI/UAS: A molecular switch to control expression of genes in vivo.
Human gene therapy 1996;7(7):809-20.
1996: Charles R Esther; Tom E Howard; E M Marino; J M Goddard; Mario R Capecchi; Kenneth E Bernstein
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.
Laboratory investigation; a journal of technical methods and pathology 1996;74(5):953-65.
1996: Allan Peter Davis; Mario R Capecchi
A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse.
Development (Cambridge, England) 1996;122(4):1175-85.
1995: B G Zeiher; E Eichwald; Joseph Zabner; J J Smith; A P Puga; Paul B McCray; Mario R Capecchi; Michael J Welsh; Kirk R Thomas
A mouse model for the delta F508 allele of cystic fibrosis.
The Journal of clinical investigation 1995;96(4):2051-64.
1995: Nancy R Manley; Mario R Capecchi
The role of Hoxa-3 in mouse thymus and thyroid development.
Development (Cambridge, England) 1995;121(7):1989-2003.
1995: Allan Peter Davis; David P Witte; Hsiu Mei Hsieh-Li; steven potter; Mario R Capecchi
Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.
Nature 1995;375(6534):791-5.
1995: D E Rancourt; T Tsuzuki; Mario R Capecchi
Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.
Genes & development 1995;9(1):108-22.
1994: Demetri D Spyropoulos; Mario R Capecchi
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.
Genes & development 1994;8(16):1949-61.
1994: Allan Peter Davis; Mario R Capecchi
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11.
Development (Cambridge, England) 1994;120(8):2187-98.
1994: Brian G Condie; Mario R Capecchi
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.
Nature 1994;370(6487):304-7.
1994: D Kostic; Mario R Capecchi
Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column.
Mechanisms of development 1994;46(3):231-47.
1994: Mario R Capecchi
Targeted gene replacement.
Scientific American 1994;270(3):52-9.
1993: Brian G Condie; Mario R Capecchi
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis.
Development (Cambridge, England) 1993;119(3):579-95.
1993: E M Carpenter; J M Goddard; O Chisaka; Nancy R Manley; Mario R Capecchi
Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain.
Development (Cambridge, England) 1993;118(4):1063-75.
1993: C Deng; Kirk R Thomas; Mario R Capecchi
Location of crossovers during gene targeting with insertion and replacement vectors.
Molecular and cellular biology 1993;13(4):2134-40.
1993: Mario R Capecchi
Mouse genetics. YACs to the rescue.
Nature 1993;362(6417):205-6.
1993: S L Mansour; J M Goddard; Mario R Capecchi
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear.
Development (Cambridge, England) 1993;117(1):13-28.
1992: C Deng; Mario R Capecchi
Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.
Molecular and cellular biology 1992;12(8):3365-71.
1992: Kirk R Thomas; C Deng; Mario R Capecchi
High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors.
Molecular and cellular biology 1992;12(7):2919-23.
1992: O Chisaka; T S Musci; Mario R Capecchi
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.
Nature 1992;355(6360):516-20.
1991: Kirk R Thomas; T S Musci; P E Neumann; Mario R Capecchi
Swaying is a mutant allele of the proto-oncogene Wnt-1.
Cell 1991;67(5):969-76.
1991: O Chisaka; Mario R Capecchi
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.
Nature 1991;350(6318):473-9.
1990: Mario R Capecchi
Gene targeting. How efficient can you get?
Nature 1990;348(6297):109.
1990: S L Mansour; Kirk R Thomas; Chu-Xia Deng; Mario R Capecchi
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7688-92.
1990: Kirk R Thomas; Mario R Capecchi
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.
Nature 1990;346(6287):847-50.
1990: Mario R Capecchi
Gene targeting: tapping the cellular telephone.
Nature 1990;344(6262):105.
1989: Mario R Capecchi
Altering the genome by homologous recombination.
Science (New York, N.Y.) 1989;244(4910):1288-92.
1989: Mario R Capecchi
The new mouse genetics: altering the genome by gene targeting.
Trends in genetics : TIG 1989;5(3):70-6.
1988: S L Mansour; Kirk R Thomas; Mario R Capecchi
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes.
Nature 1988;336(6197):348-52.
1987: Kirk R Thomas; Mario R Capecchi
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
Cell 1987;51(3):503-12.
1987: E A Wong; Mario R Capecchi
Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase.
Molecular and cellular biology 1987;7(6):2294-5.
1986: Kirk R Thomas; Mario R Capecchi
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.
Nature 1986;324(6092):34-8.
1986: J M Goddard; J J Weiland; Mario R Capecchi
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2172-6.
1986: Kirk R Thomas; K R Folger; Mario R Capecchi
High frequency targeting of genes to specific sites in the mammalian genome.
Cell 1986;44(3):419-28.
1986: Kirk R Thomas; Mario R Capecchi
Targeting of genes to specific sites in the mammalian genome.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():1101-13.
1986: E A Wong; Mario R Capecchi
Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays.
Somatic cell and molecular genetics 1986;12(1):63-72.
1985: W I Frels; J A Bluestone; Richard J Hodes; Mario R Capecchi; dinah singer
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.
Science (New York, N.Y.) 1985;228(4699):577-80.
1985: K R Folger; K Thomas; Mario R Capecchi
Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.
Molecular and cellular biology 1985;5(1):70-4.
1985: E A Wong; Mario R Capecchi
Effect of cell cycle position on transformation by microinjection.
Somatic cell and molecular genetics 1985;11(1):43-51.
1985: K R Folger; K Thomas; Mario R Capecchi
Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei.
Molecular and cellular biology 1985;5(1):59-69.
1984: F A Laski; R Belagaje; R M Hudziak; Mario R Capecchi; G P Norton; P Palese; U L RajBhandary; Phillip A Sharp
Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells.
The EMBO journal 1984;3(11):2445-52.
1984: K Folger; K Thomas; Mario R Capecchi
Analysis of homologous recombination in cultured mammalian cells.
Cold Spring Harbor symposia on quantitative biology 1984;49():123-38.
1983: J F Young; Mario R Capecchi; F A Laski; U L RajBhandary; P A Sharp; P Palese
Measurement of suppressor transfer RNA activity.
Science (New York, N.Y.) 1983;221(4613):873-5.
1983: Paul A Luciw; John M Bishop; Harold Varmus; Mario R Capecchi
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.
Cell 1983;33(3):705-16.
1982: R M Hudziak; F A Laski; U L RajBhandary; Phillip A Sharp; Mario R Capecchi
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes.
Cell 1982;31(1):137-46.
1982: K R Folger; E A Wong; G Wahl; Mario R Capecchi
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.
Molecular and cellular biology 1982;2(11):1372-87.
1980: Mario R Capecchi
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells.
Cell 1980;22(2 Pt 2):479-88.
1977: Mario R Capecchi; R A Haar; N E Capecchi; M M Sveda
The isolation of a suppressible nonsense mutant in mammalian cells.
Cell 1977;12(2):371-81.
1975: Mario R Capecchi; S H Hughes; G M Wahl
Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro.
Cell 1975;6(3):269-77.
1975: G M Wahl; S H Hughes; Mario R Capecchi
Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene.
Journal of cellular physiology 1975;85(2 Pt 1):307-20.
1975: S H Hughes; G M Wahl; Mario R Capecchi
Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase.
The Journal of biological chemistry 1975;250(1):120-6.
1974: Mario R Capecchi; N E Capecchi; S H Hughes; G M Wahl
Selective degradation of abnormal proteins in mammalian tissue culture cells.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(12):4732-6.
1973: J D Sharp; N E Capecchi; Mario R Capecchi
Altered enzymes in drug-resistant variants of mammalian tissue culture cells.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(11):3145-9.
1971: H Klein; Mario R Capecchi
Polypetide chain termination. Purification of the release factors, R1 and R2, from Escherichia coli.
The Journal of biological chemistry 1971;246(4):1055-61.
1970: Mario R Capecchi; H A Klein
Release factors mediating termination of complete proteins.
Nature 1970;226(5250):1029-33.
1969: Mario R Capecchi; H A Klein
Characterization of three proteins involved in polypeptide chain termination.
Cold Spring Harbor symposia on quantitative biology 1969;34():469-77.
1967: Mario R Capecchi
Polarity in vitro.
Journal of molecular biology 1967;30(1):213-7.
1967: Mario R Capecchi
A rapid assay for polypeptide chain termination.
Biochemical and biophysical research communications 1967;28(5):773-8.
1967: Mario R Capecchi
Polypeptide chain termination in vitro: isolation of a release factor.
Proceedings of the National Academy of Sciences of the United States of America 1967;58(3):1144-51.
1966: Mario R Capecchi
Cell-free protein synthesis programmed with R17 RNA: identification of two phage proteins.
Journal of molecular biology 1966;21(1):173-93.
1966: P L Bergquist; Mario R Capecchi
Fractionation of a suppressor sRNA.
Journal of molecular biology 1966;19(1):202-6.
1966: Mario R Capecchi
Initiation of E. coli proteins.
Proceedings of the National Academy of Sciences of the United States of America 1966;55(6):1517-24.
1966: J M Adams; Mario R Capecchi
N-formylmethionyl-sRNA as the initiator of protein synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1966;55(1):147-55.
1966: G N Gussin; Mario R Capecchi; J M Adams; J E Argetsinger; J Tooze; K Weber; J D Watson
Protein synthesis directed by DNA phage messengers.
Cold Spring Harbor symposia on quantitative biology 1966;31():157-71.