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Stephen Haggarty

Research Profile

Chemicals & Drugs

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Acetylation

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Johannes Gräff; Ji-Song Guan; Stephen Haggarty; Krista M Hennig; Nadine Joseph; Martin Kahn; Patricia F Kao; Thomas J F Nieland; Damien Rei; Alireza Samiei; Jinsoo Seo; Susan C Su; Ivana Delalle; Daniel M Fass; Wen-Yuan Wang; Li-Huei Tsai
An epigenetic blockade of cognitive functions in the neurodegenerating brain.
Peng Shi; Dongpeng Wan; Zachary Wissner-Gross; Balaram Ghosh; Stephen Haggarty; Ralph Mazitschek; Mark A Scott; Mehmet Fatih Yanik
Synapse microarray identification of small molecules that enhance synaptogenesis.
Travis L Biechele; Nathan D Camp; Daniel M Fass; Rima M Kulikauskas; Nick C Robin; Bryan D White; Corinne M Taraska; Erin C Moore; Jeanot Muster; Rakesh Karmacharya; Stephen Haggarty; Andy J Chien; Randall T Moon
Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma.

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All Publications

2012: Johannes Gräff; Ji-Song Guan; Stephen Haggarty; Krista M Hennig; Nadine Joseph; Martin Kahn; Patricia F Kao; Thomas J F Nieland; Damien Rei; Alireza Samiei; Jinsoo Seo; Susan C Su; Ivana Delalle; Daniel M Fass; Wen-Yuan Wang; Li-Huei Tsai
An epigenetic blockade of cognitive functions in the neurodegenerating brain.
Nature 2012;483(7388):222-6.
2011: Peng Shi; Dongpeng Wan; Zachary Wissner-Gross; Balaram Ghosh; Stephen Haggarty; Ralph Mazitschek; Mark A Scott; Mehmet Fatih Yanik
Synapse microarray identification of small molecules that enhance synaptogenesis.
Nature communications 2011;2():510.
2010: Travis L Biechele; Nathan D Camp; Daniel M Fass; Rima M Kulikauskas; Nick C Robin; Bryan D White; Corinne M Taraska; Erin C Moore; Jeanot Muster; Rakesh Karmacharya; Stephen Haggarty; Andy J Chien; Randall T Moon
Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma.
Chemistry & biology 2010;17(11):1177-82.
2010: Chrysanthi Samara; Christopher B Rohde; Cody L Gilleland; Stephanie Norton; Stephen Haggarty; Mehmet Fatih Yanik
Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18342-7.
2010: James E Bradner; Raymond Mak; Shyam K Tanguturi; Ralph Mazitschek; Stephen Haggarty; Kenneth Ross; Cindy Y Chang; Jocelyn Bosco; Nathan West; Elizabeth Morse; Katherine Lin; John Paul Shen; Nicholas P Kwiatkowski; Nele Gheldof; Job Dekker; Daniel J DeAngelo; Steven A Carr; Stuart L Schreiber; Todd R Golub; Benjamin L Ebert
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(28):12617-22.
2010: Jason Rihel; David A Prober; Anthony Arvanites; Kelvin Lam; Steven Zimmerman; Sumin Jang; Stephen Haggarty; David Kokel; Lee L Rubin; Randall T Peterson; Alexander F Schier
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.
Science (New York, N.Y.) 2010;327(5963):348-51.
2010: Ian Maze; Herbert E Covington; David M Dietz; Quincey LaPlant; William Renthal; Scott J Russo; Max Mechanic; Ezekiell Mouzon; Rachael L Neve; Stephen Haggarty; Yanhua Ren; Srihari C Sampath; Yasmin L Hurd; Paul Greengard; Alexander Tarakhovsky; Anne Schaefer; Eric J Nestler
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Science (New York, N.Y.) 2010;327(5962):213-6.
2009: Herbert E Covington; Ian Maze; Quincey C LaPlant; Vincent F Vialou; Yoshinori Ohnishi; Olivier Berton; Dan M Fass; William Renthal; Augustus J Rush; Emma Y Wu; Subroto Ghose; Vaishnav Krishnan; Scott J Russo; Carol Tamminga; Stephen Haggarty; Eric J Nestler
Antidepressant actions of histone deacetylase inhibitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(37):11451-60.
2009: Ji-Song Guan; Stephen Haggarty; Emanuela Giacometti; Jan-Hermen Dannenberg; Nadine Joseph; Jun Gao; Thomas J F Nieland; Ying Zhou; Xinyu Wang; Ralph Mazitschek; James E Bradner; Ronald A DePinho; Rudolf Jaenisch; Li-Huei Tsai
HDAC2 negatively regulates memory formation and synaptic plasticity.
Nature 2009;459(7243):55-60.
2009: Yingwei Mao; Xuecai Ge; Christopher L Frank; Jon M Madison; Angela N Koehler; Mary Kathryn Doud; Carlos Tassa; Erin M Berry; Takahiro Soda; Karun K Singh; Travis Biechele; Tracey L Petryshen; Randall T Moon; Stephen Haggarty; Li-Huei Tsai
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.
Cell 2009;136(6):1017-31.
2009: Christopher B Rohde; Cody Gilleland; Chrysanthi Samara; Stephanie Norton; Stephen Haggarty; Mehmet Fatih Yanik
Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2009;2009():5950-2.
2009: Richard G James; Travis L Biechele; William H Conrad; Nathan D Camp; Daniel M Fass; Michael Ben Major; Karen Sommer; Xianhua Yi; Brian S Roberts; Michele A Cleary; William T Arthur; Michael MacCoss; David J Rawlings; Stephen Haggarty; Randall T Moon
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
Science signaling 2009;2(72):ra25.
2008: Dohoon Kim; Christopher L Frank; Matthew M Dobbin; Rachel K Tsunemoto; Weihong Tu; Peter L Peng; Ji-Song Guan; Byung-Hoon Lee; Lily Y Moy; Paola Giusti; Nisha Broodie; Ralph Mazitschek; Ivanna Delalle; Stephen Haggarty; Rachael L Neve; Youming Lu; Li-Huei Tsai
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.
Neuron 2008;60(5):803-17.
2007: William Renthal; Ian Maze; Vaishnav Krishnan; Herbert E Covington; Guanghua Xiao; Arvind Kumar; Scott J Russo; Ami Graham; Nadia M Tsankova; Tod E Kippin; Kerry A Kerstetter; Rachael L Neve; Stephen Haggarty; Timothy A McKinsey; Rhonda Bassel-Duby; Eric N Olson; Eric J Nestler
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Neuron 2007;56(3):517-29.
2007: Katja Schmitz; Stephen Haggarty; Olivia M McPherson; Jon Clardy; Angela N Koehler
Detecting binding interactions using microarrays of natural product extracts.
Journal of the American Chemical Society 2007;129(37):11346-7.
2006: Justin Lamb; Emily D Crawford; David Peck; Joshua W Modell; Irene C Blat; Matthew J Wrobel; Jim Lerner; Jean-Philippe Brunet; Aravind Subramanian; Kenneth N Ross; Michael Reich; Haley Hieronymus; Guo Wei; Scott A Armstrong; Stephen Haggarty; Paul A Clemons; Ru Wei; Steven A Carr; Eric S Lander; Todd R Golub
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
Science (New York, N.Y.) 2006;313(5795):1929-35.
2006: Ethan O Perlstein; Douglas M Ruderfer; Gopal Ramachandran; Stephen Haggarty; Leonid Kruglyak; Stuart L Schreiber
Revealing complex traits with small molecules and naturally recombinant yeast strains.
Chemistry & biology 2006;13(3):319-27.
2005: Stephen Haggarty
The principle of complementarity: chemical versus biological space.
Current opinion in chemical biology 2005;9(3):296-303.
2005: Joshua J Forman; Paul A Clemons; Stuart L Schreiber; Stephen Haggarty
SpectralNET--an application for spectral graph analysis and visualization.
BMC bioinformatics 2005;6():260.
2004: Jing Huang; Heng Zhu; Stephen Haggarty; David R Spring; Heejun Hwang; Fulai Jin; Michael Snyder; Stuart L Schreiber
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16594-9.
2004: Stephen Haggarty; Paul A Clemons; Jason C Wong; Stuart L Schreiber
Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors.
Combinatorial chemistry & high throughput screening 2004;7(7):669-76.
2004: Bridget K Wagner; Stephen Haggarty; Paul A Clemons
Chemical genomics: probing protein function using small molecules.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2004;4(5):313-20.
2003: Stephen Haggarty; Kathryn M Koeller; Tweeny R Kau; Pamela A Silver; Michel Roberge; Stuart L Schreiber
Small molecule modulation of the human chromatid decatenation checkpoint.
Chemistry & biology 2003;10(12):1267-79.
2003: Stephen Haggarty; Paul A Clemons; Stuart L Schreiber
Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations.
Journal of the American Chemical Society 2003;125(35):10543-5.
2003: Kathryn M Koeller; Stephen Haggarty; Brian D Perkins; Igor Leykin; Jason C Wong; Ming-Chih J Kao; Stuart L Schreiber
Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation.
Chemistry & biology 2003;10(5):397-410.
2003: Stephen Haggarty; Kathryn M Koeller; Jason C Wong; Rebecca A Butcher; Stuart L Schreiber
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays.
Chemistry & biology 2003;10(5):383-96.
2003: Stephen Haggarty; Kathryn M Koeller; Jason C Wong; Christina M Grozinger; Stuart L Schreiber
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4389-94.
2000: Stephen Haggarty; Thomas U Mayer; David Miyamoto; Reza Fathi; Randall W King; Timothy J Mitchison; Stuart L Schreiber
Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis.
Chemistry & biology 2000;7(4):275-86.
2000: Stephen Haggarty; M Ramalho-Santos
Will cell alliance breed bureaucracy and leave contributors out?
Nature 2000;403(6770):591.
1999: Thomas U Mayer; Tarun M Kapoor; Stephen Haggarty; Randall W King; Stuart L Schreiber; Timothy J Mitchison
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Science (New York, N.Y.) 1999;286(5441):971-4.
1999: B R Stockwell; Stephen Haggarty; Stuart L Schreiber
High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications.
Chemistry & biology 1999;6(2):71-83.
1998: Michel Roberge; Roberto G S Berlinck; L Xu; Hilary J Anderson; Lynette Y Lim; Darko Curman; C M Stringer; Stephen H Friend; P Davies; I Vincent; Stephen Haggarty; Michael T Kelly; Robert Britton; Edward Piers; Raymond J Andersen
High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.
Cancer research 1998;58(24):5701-6.