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Winald Gerritsen

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Saskia J A M Santegoets; Rik J Scheper; Petra E T Scholten; Anita G M Stam; Alfons J M van den Eertwegh; B Mary E von Blomberg; Jean-Marie Cuillerot; Helen Gall; Winald Gerritsen; Kristen Hege; Karin Jooss; Sinéad M Lougheed; Israel Lowy; Martine Reijm; Natalie Sacks; Tanja D de Gruijl
T cell profiling reveals high CD4+CTLA-4 + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment.
Charles J Ryan; Fred Saad; Howard I Scher; Dirk Schrijvers; Eric J Small; Matthew R Smith; Henrik Suttmann; Mary-Ellen Taplin; Hendrik Van Poppel; Eric Winquist; Evan Y Yu; Ethan Basch; Joan Carles; Johann S de Bono; Paul de Souza; Eleni Efstathiou; Karim Fizazi; Thomas W Flaig; Daniel J George; Winald Gerritsen; Thomas Griffin; Celestia S Higano; Thian Kheoh; Christopher J Logothetis; Paul Mainwaring; Arturo Molina; Som D Mukherjee; Peter F A Mulders; Siobhan Ng; Allan Pantuck; Youn Park; Josep M Piulats; Dana E Rathkopf
Abiraterone in metastatic prostate cancer without previous chemotherapy.
Charles J Ryan; Sandy Srinivas; Rui Tang; Min Zhu; Joshi Alumkal; Sarita Dubey; Karim Fizazi; Frédéric Forget; Gwenaëlle Gravis; Yizhou Jiang; Elwyn Loh; Jean-Pascal Machiels; Siobhan Ng; Kelly S Oliner; Joel Picus; Mark Rosenthal; Winald Gerritsen
Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone.

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2013: Saskia J A M Santegoets; Rik J Scheper; Petra E T Scholten; Anita G M Stam; Alfons J M van den Eertwegh; B Mary E von Blomberg; Jean-Marie Cuillerot; Helen Gall; Winald Gerritsen; Kristen Hege; Karin Jooss; Sinéad M Lougheed; Israel Lowy; Martine Reijm; Natalie Sacks; Tanja D de Gruijl
T cell profiling reveals high CD4+CTLA-4 + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment.
Cancer immunology, immunotherapy : CII 2013;62(2):245-56.
2013: Charles J Ryan; Fred Saad; Howard I Scher; Dirk Schrijvers; Eric J Small; Matthew R Smith; Henrik Suttmann; Mary-Ellen Taplin; Hendrik Van Poppel; Eric Winquist; Evan Y Yu; Ethan Basch; Joan Carles; Johann S de Bono; Paul de Souza; Eleni Efstathiou; Karim Fizazi; Thomas W Flaig; Daniel J George; Winald Gerritsen; Thomas Griffin; Celestia S Higano; Thian Kheoh; Christopher J Logothetis; Paul Mainwaring; Arturo Molina; Som D Mukherjee; Peter F A Mulders; Siobhan Ng; Allan Pantuck; Youn Park; Josep M Piulats; Dana E Rathkopf
Abiraterone in metastatic prostate cancer without previous chemotherapy.
The New England journal of medicine 2013;368(2):138-48.
2013: Charles J Ryan; Sandy Srinivas; Rui Tang; Min Zhu; Joshi Alumkal; Sarita Dubey; Karim Fizazi; Frédéric Forget; Gwenaëlle Gravis; Yizhou Jiang; Elwyn Loh; Jean-Pascal Machiels; Siobhan Ng; Kelly S Oliner; Joel Picus; Mark Rosenthal; Winald Gerritsen
Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(1):215-24.
2012: Hielke J Meulenbeld; M Polee; Albert J ten Tije; E D van Werkhoven; J L L M Coenen; Geert-Jan Creemers; O Dalesio; P C de Jong; Sophie D Fosså; Winald Gerritsen; O J L Loosveld; Ronald de Wit
Randomised phase II/III study of docetaxel with or without risedronate in patients with metastatic Castration Resistant Prostate Cancer (CRPC), the Netherlands Prostate Study (NePro).
European journal of cancer (Oxford, England : 1990) 2012;48(16):2993-3000.
2012: Winald Gerritsen
The evolving role of immunotherapy in prostate cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2012;23 Suppl 8():viii22-7.
2012: Alfons J M van den Eertwegh; Tim M van der Sluis; R Jeroen A Van Moorselaar; Jurjen Versluis; B Mary E von Blomberg; Tanja D de Gruijl; Helen E Gall; Thomas C Harding; Kristen Hege; Karin Jooss; Israel Lowy; HERBERT PINEDO; Natalie Sacks; Saskia J A M Santegoets; Rik J Scheper; Anita G M Stam; H Pieter van den Berg; Winald Gerritsen
Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial.
The lancet oncology 2012;13(5):509-17.
2012: Winald Gerritsen; Padmanee Sharma
Current and emerging treatment options for castration-resistant prostate cancer: a focus on immunotherapy.
Journal of clinical immunology 2012;32(1):25-35.
2012: Daniela E Oprea-Lager; Alfons J M van den Eertwegh; Reindert J A van Moorselaar; Andrew D Vincent; Ronald Boellaard; Jonas Eriksson; Winald Gerritsen; Otto S Hoekstra
Dual-phase PET-CT to differentiate [18F]Fluoromethylcholine uptake in reactive and malignant lymph nodes in patients with prostate cancer.
PloS one 2012;7(10):e48430.
2011: R Jonas A Nilsson; David P Noske; D Michiel Pegtel; Johan Skog; Sjoerd van Rijn; W Peter Vandertop; Hendrik Verheul; Maudy Walraven; Anders Widmark; Leonora Balaj; Winald Gerritsen; Esther Hulleman; T Würdinger
Blood platelets contain tumor-derived RNA biomarkers.
Blood 2011;118(13):3680-3.
2011: Basav N Hangalapura; Dinja Oosterhoff; Alexander Pereboev; Rik J Scheper; Thomas Tüting; Victor W van Beusechem; Alfons J van den Eertwegh; Louis Boon; David T Curiel; Jan de Groot; Winald Gerritsen; Tanja D de Gruijl
Potent antitumor immunity generated by a CD40-targeted adenoviral vaccine.
Cancer research 2011;71(17):5827-37.
2010: Astrid A M van der Veldt; N Harry Hendrikse; Egbert F Smit; Martien P J Mooijer; Anneloes Y Rijnders; Winald Gerritsen; Jacobus J M van Der Hoeven; Albert D Windhorst; Adriaan A Lammertsma; Mark Lubberink
Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients.
European journal of nuclear medicine and molecular imaging 2010;37(10):1950-8.
2009: MH Verheije; Martine L M Lamfers; T Würdinger; Guy C M Grinwis; Winald Gerritsen; Victor W van Beusechem; Peter J M Rottier
Coronavirus genetically redirected to the epidermal growth factor receptor exhibits effective antitumor activity against a malignant glioblastoma.
Journal of virology 2009;83(15):7507-16.
2009: S E Pentinga; H G Bruining; Winald Gerritsen; A J M van den Eertwegh; Thomas Rustemeyer
A case of delayed-type hypersensitivity to subcutaneously administered drugs during anticancer immunotherapy.
The British journal of dermatology 2009;160(5):1132-4.
2008: Harm C A Graat; Victor W van Beusechem; Frederik H E Schagen; M Adhiambo Witlox; Eugenie S Kleinerman; Marco N Helder; Winald Gerritsen; G J L Kaspers; Paul I J M Wuisman
Intravenous administration of the conditionally replicative adenovirus Ad5-Delta24RGD induces regression of osteosarcoma lung metastases.
Molecular cancer 2008;7():9.
2007: Martine L M Lamfers; Sander Idema; Lisette Bosscher; Stan Heukelom; Sharif Moeniralm; Ida H van der Meulen-Muileman; Renée M Overmeer; Paul Van Der Valk; Victor W van Beusechem; Winald Gerritsen; W Peter Vandertop; Clemens M F Dirven
Differential effects of combined Ad5- delta 24RGD and radiation therapy in in vitro versus in vivo models of malignant glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(24):7451-8.
2007: Sander Idema; Martine L M Lamfers; Victor W van Beusechem; David P Noske; Stan Heukelom; Sharif Moeniralm; Winald Gerritsen; W Peter Vandertop; Clemens M F Dirven
AdDelta24 and the p53-expressing variant AdDelta24-p53 achieve potent anti-tumor activity in glioma when combined with radiotherapy.
The journal of gene medicine 2007;9(12):1046-56.
2007: Harm C A Graat; Jan E Carette; Frederik H E Schagen; Lyubomir T Vassilev; Winald Gerritsen; G J L Kaspers; Paul I J M Wuisman; Victor W van Beusechem
Enhanced tumor cell kill by combined treatment with a small-molecule antagonist of mouse double minute 2 and adenoviruses encoding p53.
Molecular cancer therapeutics 2007;6(5):1552-61.
2007: Jan E Carette; Harm C A Graat; Frederik H E Schagen; D C Jeroen Mastenbroek; Marianne G Rots; Hidde J Haisma; Geny M M Groothuis; Gerard R Schaap; Johannes Bras; G J L Kaspers; Paul I J M Wuisman; Winald Gerritsen; Victor W van Beusechem
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor.
Virology 2007;361(1):56-67.
2007: Sander Idema; Albert A Geldof; Clemens M F Dirven; M van der Jagt; Winald Gerritsen; W Peter Vandertop; Martine L M Lamfers
Evaluation of adenoviral oncolytic effect on glioma spheroids by 18F-DG positron-emission tomography.
Oncology research 2007;16(10):471-7.
2006: T Würdinger; MH Verheije; L M van der Aa; Berend Jan Bosch; Cornelis de Haan; Victor W van Beusechem; Winald Gerritsen; Peter J M Rottier
Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells.
Leukemia 2006;20(12):2182-4.
2006: Manon S A Boddaert; Winald Gerritsen; HERBERT PINEDO
On our way to targeted therapy for cachexia in cancer?
Current opinion in oncology 2006;18(4):335-40.
2006: Harm C A Graat; M Adhiambo Witlox; Frederik H E Schagen; G J L Kaspers; Marco N Helder; Johannes Bras; Gerard R Schaap; Winald Gerritsen; Paul I J M Wuisman; Victor W van Beusechem
Different susceptibility of osteosarcoma cell lines and primary cells to treatment with oncolytic adenovirus and doxorubicin or cisplatin.
British journal of cancer 2006;94(12):1837-44.
2006: Frederik H E Schagen; Felix M Wensveen; Jan E Carette; Terence S Dermody; Winald Gerritsen; Victor W van Beusechem
Genetic targeting of adenovirus vectors using a reovirus sigma1-based attachment protein.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(5):997-1005.
2006: MH Verheije; T Würdinger; Victor W van Beusechem; Cornelis de Haan; Winald Gerritsen; Peter J M Rottier
Redirecting coronavirus to a nonnative receptor through a virus-encoded targeting adapter.
Journal of virology 2006;80(3):1250-60.
2005: Rosalie M Luiten; Esther W M Kueter; Wolter J Mooi; Maarten P W Gallee; Elaine M Rankin; Winald Gerritsen; Shirley M Clift; Willem Nooijen; Pauline Weder; Willeke F van de Kasteele; Johan Sein; Paul van den Berk; Omgo E Nieweg; Anton M Berns; Hergen Spits; Gijsbert C De Gast
Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(35):8978-91.
2005: T Würdinger; MH Verheije; K Broen; Berend Jan Bosch; Bert Jan Haijema; Cornelis de Haan; Victor W van Beusechem; Winald Gerritsen; Peter J M Rottier
Soluble receptor-mediated targeting of mouse hepatitis coronavirus to the human epidermal growth factor receptor.
Journal of virology 2005;79(24):15314-22.
2005: Daniëlle A M Heideman; Renske D M Steenbergen; Jaco van der Torre; Martin Scheffner; Ramon Alemany; Winald Gerritsen; Chris J L M Meijer; Peter J F Snijders; Victor W van Beusechem
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1083-90.
2005: Daniëlle A M Heideman; Renée M Overmeer; Victor W van Beusechem; Wouter H Lamers; Theodorus B M Hakvoort; Peter J F Snijders; Mikael E Craanen; G Johan A Offerhaus; Chris J L M Meijer; Winald Gerritsen
Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy.
Cancer gene therapy 2005;12(12):954-62.
2005: Martine L M Lamfers; Davide Gianni; Ching-Hsuan Tung; Sander Idema; Frederik H E Schagen; Jan E Carette; Paul H A Quax; Victor W van Beusechem; W Peter Vandertop; Clemens M F Dirven; E Antonio Chiocca; Winald Gerritsen
Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma.
Cancer research 2005;65(20):9398-405.
2005: T Würdinger; MH Verheije; Matthijs Raaben; Berend Jan Bosch; Cornelis de Haan; Victor W van Beusechem; Peter J M Rottier; Winald Gerritsen
Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody.
Gene therapy 2005;12(18):1394-404.
2005: Jan E Carette; Harm C A Graat; Frederik H E Schagen; Mohamed A I Abou El Hassan; Winald Gerritsen; Victor W van Beusechem
Replication-dependent transgene expression from a conditionally replicating adenovirus via alternative splicing to a heterologous splice-acceptor site.
The journal of gene medicine 2005;7(8):1053-62.
2005: Victor W van Beusechem; Petra B van den Doel; Winald Gerritsen
Conditionally replicative adenovirus expressing degradation-resistant p53 for enhanced oncolysis of human cancer cells overexpressing murine double minute 2.
Molecular cancer therapeutics 2005;4(6):1013-8.
2005: Dinja Oosterhoff; HERBERT PINEDO; M Adhiambo Witlox; Jan E Carette; Winald Gerritsen; Victor W van Beusechem
Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.
Gene therapy 2005;12(12):1011-8.
2005: Birgit Geoerger; Victor W van Beusechem; Paule Opolon; Jackie Morizet; Lysiane Laudani; Yann Lecluse; Michel Barrois; Sander Idema; jacques grill; Winald Gerritsen; Gilles Vassal
Expression of p53, or targeting towards EGFR, enhances the oncolytic potency of conditionally replicative adenovirus against neuroblastoma.
The journal of gene medicine 2005;7(5):584-94.
2005: Harm C A Graat; Paul I J M Wuisman; Victor W van Beusechem; Jan E Carette; Winald Gerritsen; Johannes Bras; Gerard R Schaap; G J L Kaspers; Akira Ogose; Wenguang Gu; Hiroyuki Kawashima; Tetsuo Hotta
Coxsackievirus and adenovirus receptor expression on primary osteosarcoma specimens and implications for gene therapy with recombinant adenoviruses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(6):2445-7; author reply 2447-8.
2005: Dinja Oosterhoff; Renée M Overmeer; Michelle de Graaf; I H van der Meulen; Giuseppe Giaccone; Victor W van Beusechem; Hidde J Haisma; HERBERT PINEDO; Winald Gerritsen
Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11.
British journal of cancer 2005;92(5):882-7.
2005: jacques grill; Martine L M Lamfers; Victor W van Beusechem; Paul Van Der Valk; Anne Huisman; Peter Sminia; Ramon Alemany; David T Curiel; W Peter Vandertop; Winald Gerritsen; Clemens M F Dirven
Oncolytic virotherapy of meningiomas in vitro with replication-competent adenovirus.
Neurosurgery 2005;56(1):146-53; discussion 153-4.
2004: Birgit Geoerger; Gilles Vassal; Paule Opolon; Clemens M F Dirven; Jackie Morizet; Lysiane Laudani; jacques grill; Giuseppe Giaccone; W Peter Vandertop; Winald Gerritsen; Victor W van Beusechem
Oncolytic activity of p53-expressing conditionally replicative adenovirus AdDelta24-p53 against human malignant glioma.
Cancer research 2004;64(16):5753-9.
2004: Miriam Ferrer; Johan P de Winter; D C Jeroen Mastenbroek; David T Curiel; Winald Gerritsen; Giuseppe Giaccone; Frank A E Kruyt
Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA.
Cancer gene therapy 2004;11(8):539-46.
2004: Mohamed A I Abou El Hassan; D C Jeroen Mastenbroek; Winald Gerritsen; Giuseppe Giaccone; Frank A E Kruyt
Overexpression of Bcl2 abrogates chemo- and radiotherapy-induced sensitisation of NCI-H460 non-small-cell lung cancer cells to adenovirus-mediated expression of full-length TRAIL.
British journal of cancer 2004;91(1):171-7.
2004: Markus D Sachs; Meera Ramamurthy; Henk van der Poel; Thomas J Wickham; Martine L M Lamfers; Winald Gerritsen; Wasim H Chowdhury; Ying Li; Mark P Schoenberg; Ronald Rodriguez
Histone deacetylase inhibitors upregulate expression of the coxsackie adenovirus receptor (CAR) preferentially in bladder cancer cells.
Cancer gene therapy 2004;11(7):477-86.
2004: Daniel H Palmer; Vivien Mautner; Darius F Mirza; Simon Oliff; Winald Gerritsen; J R M van der Sijp; Stefan G Hubscher; Gary Reynolds; Sarah Bonney; Ratna Rajaratnam; Diana Hull; Mark Horne; John Ellis; Andrew Mountain; Simon Hill; Peter A Harris; Peter F Searle; Lawrence S Young; Nicholas James; David J Kerr
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(9):1546-52.
2004: Jan E Carette; Renée M Overmeer; Frederik H E Schagen; Ramon Alemany; Oleg A Barski; Winald Gerritsen; Victor W van Beusechem
Conditionally replicating adenoviruses expressing short hairpin RNAs silence the expression of a target gene in cancer cells.
Cancer research 2004;64(8):2663-7.
2004: Daniëlle A M Heideman; Victor W van Beusechem; Elisabeth Bloemena; Peter J F Snijders; Mikael E Craanen; G Johan A Offerhaus; Patrick W B Derksen; Michiel de Bruin; M Adhiambo Witlox; Bonnie Molenaar; Chris J L M Meijer; Winald Gerritsen
Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4.
The journal of gene medicine 2004;6(3):317-27.
2004: Michelle de Graaf; HERBERT PINEDO; Dinja Oosterhoff; Ida H van der Meulen-Muileman; Winald Gerritsen; Hidde J Haisma; Epie Boven
Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein.
Human gene therapy 2004;15(3):229-38.
2004: Adhiambo M Witlox; Victor W van Beusechem; Bonnie Molenaar; Hans Bras; Gerard R Schaap; Ramon Alemany; David T Curiel; HERBERT PINEDO; Paul I J M Wuisman; Winald Gerritsen
Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):61-7.
2003: jacques grill; Birgit Geoerger; Martine L M Lamfers; Clemens M F Dirven; Victor W van Beusechem; Winald Gerritsen; Gilles Vassal
[Conditionally replicative adenoviruses: a second wind for cancer gene therapy].
Bulletin du cancer 2003;90(12):1039-48.
2003: Victor W van Beusechem; D C Jeroen Mastenbroek; Petra B van den Doel; Martine L M Lamfers; jacques grill; T Würdinger; Hidde J Haisma; HERBERT PINEDO; Winald Gerritsen
Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors.
Gene therapy 2003;10(23):1982-91.
2003: Birgit Geoerger; jacques grill; Paule Opolon; Jackie Morizet; Geneviève Aubert; Yann Lecluse; Victor W van Beusechem; Winald Gerritsen; D H Kirn; Gilles Vassal
Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts.
British journal of cancer 2003;89(3):577-84.
2003: Dinja Oosterhoff; M Adhiambo Witlox; Victor W van Beusechem; Hidde J Haisma; Gerard R Schaap; Johannes Bras; Frank A E Kruyt; Bonnie Molenaar; Epie Boven; Paul I J M Wuisman; HERBERT PINEDO; Winald Gerritsen
Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2.
Molecular cancer therapeutics 2003;2(8):765-71.
2003: Joana G Brandão; Rik J Scheper; Sinéad M Lougheed; David T Curiel; Bryan W Tillman; Winald Gerritsen; Alfons J M van den Eertwegh; HERBERT PINEDO; Hidde J Haisma; Tanja D de Gruijl
CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation.
Vaccine 2003;21(19-20):2268-72.
2003: Marianne G Rots; DT Curiel; Winald Gerritsen; Hidde J Haisma
Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):159-65.
2002: Clemens M F Dirven; Victor W van Beusechem; Martine L M Lamfers; jacques grill; Winald Gerritsen; W Peter Vandertop
Oncolytic adenoviruses for treatment of brain tumours.
Expert opinion on biological therapy 2002;2(8):943-52.
2002: Victor W van Beusechem; Petra B van den Doel; jacques grill; HERBERT PINEDO; Winald Gerritsen
Conditionally replicative adenovirus expressing p53 exhibits enhanced oncolytic potency.
Cancer research 2002;62(21):6165-71.
2002: jacques grill; Martine L M Lamfers; Victor W van Beusechem; Clemens M F Dirven; D Shareen Pherai; Mathijs Kater; Paul Van Der Valk; Ronald Vogels; W Peter Vandertop; HERBERT PINEDO; David T Curiel; Winald Gerritsen
The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):609-14.
2002: Tanja D de Gruijl; Sylvia A Luykx-de Bakker; Bryan W Tillman; Alfons J M van den Eertwegh; Jan Buter; Sinéad M Lougheed; Gerben J van der Bij; A Mahmoud Safer; Hidde J Haisma; David T Curiel; Rik J Scheper; HERBERT PINEDO; Winald Gerritsen
Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin explants after in situ delivery of CD40-targeted adenoviral vectors.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5322-31.
2002: Martine L M Lamfers; jacques grill; Clemens M F Dirven; Victor W van Beusechem; Birgit Geoerger; Jaap Van Den Berg; Ramon Alemany; Juan Fueyo; David T Curiel; Gilles Vassal; HERBERT PINEDO; W Peter Vandertop; Winald Gerritsen
Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.
Cancer research 2002;62(20):5736-42.
2002: Daniëlle A M Heideman; Victor W van Beusechem; G Johan A Offerhaus; Thomas J Wickham; Peter W Roelvink; Mikael E Craanen; HERBERT PINEDO; Chris J L M Meijer; Winald Gerritsen
Selective gene transfer into primary human gastric tumors using epithelial cell adhesion molecule-targeted adenoviral vectors with ablated native tropism.
Human gene therapy 2002;13(14):1677-85.
2002: Dinja Oosterhoff; HERBERT PINEDO; I H van der Meulen; Michelle de Graaf; T Sone; Frank A E Kruyt; Victor W van Beusechem; Hidde J Haisma; Winald Gerritsen
Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
British journal of cancer 2002;87(6):659-64.
2002: M Adhiambo Witlox; Victor W van Beusechem; jacques grill; Hidde J Haisma; Gerard R Schaap; Johannes Bras; Paulus van Diest; Arthur de Gast; David T Curiel; HERBERT PINEDO; Winald Gerritsen; Paul I J M Wuisman
Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma.
The journal of gene medicine 2002;4(5):510-6.
2002: Clemens M F Dirven; jacques grill; Martine L M Lamfers; Paul Van Der Valk; Angelique M Leonhart; Victor W van Beusechem; Hidde J Haisma; HERBERT PINEDO; David T Curiel; W Peter Vandertop; Winald Gerritsen
Gene therapy for meningioma: improved gene delivery with targeted adenoviruses.
Journal of neurosurgery 2002;97(2):441-9.
2002: H G van der Poel; Bonnie Molenaar; Victor W van Beusechem; Hidde J Haisma; Ronald Rodriguez; David T Curiel; Winald Gerritsen
Epidermal growth factor receptor targeting of replication competent adenovirus enhances cytotoxicity in bladder cancer.
The Journal of urology 2002;168(1):266-72.
2002: Carlijn Voermans; W P M van Heese; I de Jong; Winald Gerritsen; C Ellen van der Schoot
Migratory behavior of leukemic cells from acute myeloid leukemia patients.
Leukemia 2002;16(4):650-7.
2002: Michelle de Graaf; Epie Boven; Dinja Oosterhoff; Ida H van der Meulen-Muileman; G A Huls; Winald Gerritsen; Hidde J Haisma; HERBERT PINEDO
A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug.
British journal of cancer 2002;86(5):811-8.
2002: Victor W van Beusechem; jacques grill; D C Jeroen Mastenbroek; Thomas J Wickham; Peter W Roelvink; Hidde J Haisma; Martine L M Lamfers; Clemens M F Dirven; HERBERT PINEDO; Winald Gerritsen
Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished.
Journal of virology 2002;76(6):2753-62.
2001: Winald Gerritsen; M R Krul
Highlights of the Second International Symposium on Genetic Anticancer Agents.
Cancer gene therapy 2001;8(9):678-80.
2001: Daniëlle A M Heideman; Peter J F Snijders; Elisabeth Bloemena; Chris J L M Meijer; G Johan A Offerhaus; S G M Meuwissen; Winald Gerritsen; Mikael E Craanen
Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma.
The Journal of pathology 2001;194(4):428-35.
2001: Michelle de Graaf; I C van Veen; Ida H van der Meulen-Muileman; Winald Gerritsen; HERBERT PINEDO; Hidde J Haisma
Cloning and characterization of human liver cytosolic beta-glycosidase.
The Biochemical journal 2001;356(Pt 3):907-10.
2001: Daniëlle A M Heideman; Peter J F Snijders; Mikael E Craanen; Elisabeth Bloemena; Chris J L M Meijer; S G M Meuwissen; Victor W van Beusechem; HERBERT PINEDO; D T Curiel; H J Haisma; Winald Gerritsen
Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors.
Cancer gene therapy 2001;8(5):342-51.
2001: jacques grill; Victor W van Beusechem; Paul Van Der Valk; Clemens M F Dirven; A Leonhart; D S Pherai; Hidde J Haisma; HERBERT PINEDO; David T Curiel; Winald Gerritsen
Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):641-50.
2001: Carlijn Voermans; ML Kooi; Sjoerd Rodenhuis; H van der Lelie; C Ellen van der Schoot; Winald Gerritsen
In vitro migratory capacity of CD34+ cells is related to hematopoietic recovery after autologous stem cell transplantation.
Blood 2001;97(3):799-804.
2000: Victor W van Beusechem; Angélique L C T van Rijswijk; H H van Es; Hidde J Haisma; HERBERT PINEDO; Winald Gerritsen
Recombinant adenovirus vectors with knobless fibers for targeted gene transfer.
Gene therapy 2000;7(22):1940-6.
2000: PM Rood; M W Dercksen; H Cazemier; J Martijn Kerst; Albert E G Kr von dem Borne; Winald Gerritsen; C Ellen van der Schoot
E-selectin and very late activation antigen-4 mediate adhesion of hematopoietic progenitor cells to bone marrow endothelium.
Annals of hematology 2000;79(9):477-84.
2000: David T Curiel; Winald Gerritsen; M R Krul
Progress in cancer gene therapy.
Cancer gene therapy 2000;7(8):1197-9.
2000: Anneke M Westermann; Babs G Taal; M Swart; H Boot; Mikael E Craanen; Winald Gerritsen
Sequence-dependent toxicity profile in modified FAMTX (fluorouracil-adriamycin-methotrexate) chemotherapy with lenograstim support for advanced gastric cancer: a feasibility study.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(2):151-6.
2000: PM Rood; Jero Calafat; Albert E G Kr von dem Borne; Winald Gerritsen; C Ellen van der Schoot
Immortalisation of human bone marrow endothelial cells: characterisation of new cell lines.
European journal of clinical investigation 2000;30(7):618-29.
2000: Hidde J Haisma; jacques grill; David T Curiel; S Hoogeland; Victor W van Beusechem; HERBERT PINEDO; Winald Gerritsen
Targeting of adenoviral vectors through a bispecific single-chain antibody.
Cancer gene therapy 2000;7(6):901-4.
2000: Daniëlle A M Heideman; Winald Gerritsen; Mikael E Craanen
Gene therapy for gastrointestinal tract cancer: a review.
Scandinavian journal of gastroenterology. Supplement 2000;(232):93-100.
2000: Carlijn Voermans; PM Rood; Peter L Hordijk; Winald Gerritsen; C Ellen van der Schoot
Adhesion molecules involved in transendothelial migration of human hematopoietic progenitor cells.
Stem cells (Dayton, Ohio) 2000;18(6):435-43.
1999: Carlijn Voermans; Winald Gerritsen; A E von dem Borne; C Ellen van der Schoot
Increased migration of cord blood-derived CD34+ cells, as compared to bone marrow and mobilized peripheral blood CD34+ cells across uncoated or fibronectin-coated filters.
Experimental hematology 1999;27(12):1806-14.
1999: María José Fonseca; Gert Storm; Wim E Hennink; Winald Gerritsen; Hidde J Haisma
Cationic polymeric gene delivery of beta-glucuronidase for doxorubicin prodrug therapy.
The journal of gene medicine 1999;1(6):407-14.
1999: IS Weimar; Kees Weijer; Paul van den Berk; EJ Muller; N Miranda; Arjen Q Bakker; Mirjam H M Heemskerk; A Hekman; Gijsbert C De Gast; Winald Gerritsen
HGF/SF and its receptor c-MET play a minor role in the dissemination of human B-lymphoma cells in SCID mice.
British journal of cancer 1999;81(1):43-53.
1999: Hidde J Haisma; HERBERT PINEDO; A Rijswijk; I der Meulen-Muileman; Barbara A Sosnowski; W Ying; V W Beusechem; Bryan W Tillman; Winald Gerritsen; David T Curiel
Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM.
Gene therapy 1999;6(8):1469-74.
1999: PM Rood; Winald Gerritsen; D Kramer; C Ranzijn; Albert E G Kr von dem Borne; C Ellen van der Schoot
Adhesion of hematopoietic progenitor cells to human bone marrow or umbilical vein derived endothelial cell lines: a comparison.
Experimental hematology 1999;27(8):1306-14.
1999: Bryan W Tillman; Tanja D de Gruijl; Sylvia A Luykx-de Bakker; Rik J Scheper; HERBERT PINEDO; Tyler J Curiel; Winald Gerritsen; David T Curiel
Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6378-83.
1998: IS Weimar; Carlijn Voermans; J H Bourhis; N Miranda; Paul van den Berk; T Nakamura; Gijsbert C De Gast; Winald Gerritsen
Hepatocyte growth factor/scatter factor (HGF/SF) affects proliferation and migration of myeloid leukemic cells.
Leukemia 1998;12(8):1195-203.
1998: IS Weimar; N Miranda; EJ Muller; A Hekman; J Martijn Kerst; Gijsbert C De Gast; Winald Gerritsen
Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+).
Experimental hematology 1998;26(9):885-94.
1997: Claudia C Folman; Albert E G Kr von dem Borne; I H Rensink; Winald Gerritsen; C Ellen van der Schoot; Masja de Haas; L Aarden
Sensitive measurement of thrombopoietin by a monoclonal antibody based sandwich enzyme-linked immunosorbent assay.
Thrombosis and haemostasis 1997;78(4):1262-7.
1997: IS Weimar; Daphne de Jong; EJ Muller; T Nakamura; J M van Gorp; Gijsbert C De Gast; Winald Gerritsen
Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via alpha 4 beta 1 and alpha 5 beta 1 integrins.
Blood 1997;89(3):990-1000.
1996: Joke W Baars; M J Holtkamp; W J Nooyen; E V Walll; Anje A Te Velde; Otilia Dalesio; Ineke Slaper-Cortenbach; E V Schoot; Dick J Richel; Winald Gerritsen; Jan H Schornagel; Sjoerd Rodenhuis
Mobilisation of blood progenitor cells with ifosfamide and etoposide (VP-16) in combination with recombinant human G-CSF (Filgrastim) in patients with malignant lymphomas or solid tumours.
Anticancer research 1996;16(5B):3089-95.
1995: M W Dercksen; IS Weimar; Dick J Richel; J Breton-Gorius; W Vainchenker; C M Slaper-Cortenbach; HERBERT PINEDO; A E von dem Borne; Winald Gerritsen; C Ellen van der Schoot
The value of flow cytometric analysis of platelet glycoprotein expression of CD34+ cells measured under conditions that prevent P-selectin-mediated binding of platelets.
Blood 1995;86(10):3771-82.
1995: O Soepenberg; IS Weimar; L T Oei; A E von dem Borne; P C Huijgens; Winald Gerritsen
[Myelodysplastic syndrome; current insights in pathogenesis and treatment].
Nederlands tijdschrift voor geneeskunde 1995;139(42):2130-5.
1995: A E von dem Borne; Winald Gerritsen
[Thrombopoietin produced molecularly-biologically].
Nederlands tijdschrift voor geneeskunde 1995;139(38):1922-7.
1995: M W Dercksen; Winald Gerritsen; Sjoerd Rodenhuis; M K Dirkson; Ineke Slaper-Cortenbach; Wim Schaasberg; HERBERT PINEDO; A E von dem Borne; C Ellen van der Schoot
Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation.
Blood 1995;85(11):3313-9.
1994: Winald Gerritsen; Richard J O'Reilly
Granulocyte colony-stimulating factor (CSF) but not interleukin-1 (IL-1), IL-3, and granulocyte-macrophage CSF protect bone marrow progenitor cells from suppression by allosensitized cytotoxic T cells.
Blood 1994;84(6):1906-12.
1994: Winald Gerritsen; C A Jagiello; J H Bourhis
Detection of chimerism in subpopulations of cells by fluorescence in situ hybridization and immunofluorescent staining of cell surface antigens.
Bone marrow transplantation 1994;13(4):441-7.
1994: IS Weimar; J H Bourhis; Gijsbert C De Gast; Winald Gerritsen
Clonality in myelodysplastic syndromes.
Leukemia & lymphoma 1994;13(3-4):215-21.
1992: Winald Gerritsen; J Donohue; J Bauman; Suresh C Jhanwar; Nancy A Kernan; Hugo Castro-Malaspina; Richard J O'Reilly; J H Bourhis
Clonal analysis of myelodysplastic syndrome: monosomy 7 is expressed in the myeloid lineage, but not in the lymphoid lineage as detected by fluorescent in situ hybridization.
Blood 1992;80(1):217-24.
1988: Winald Gerritsen; Gerard Wagemaker; M Jonker; M J Kenter; JJ Wielenga; G Hale; H Waldmann; D W van Bekkum
The repopulation capacity of bone marrow grafts following pretreatment with monoclonal antibodies against T lymphocytes in rhesus monkeys.
Transplantation 1988;45(2):301-7.