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Natasha Caplen

Research Profile

Chemicals & Drugs

Procedures

Phenomena

RNA Interference

Disorders

Cystic Fibrosis

Anatomy

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Gene Transfer Techniques

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Publications

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Jordi Camps; Natasha J Caplen; Chanelle M Case; Michael J Difilippantonio; Georg Emons; B Michael Ghadimi; Marian Grade; Amanda B Hummon; Tamara L Jones; Quang T Nguyen; Jason J Pitt; Tim Beissbarth; Thomas Ried
Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer.
Anthony M Barsotti; Rachel Beckerman; Natasha J Caplen; Konrad Huppi; Oleg Laptenko; Carol Prives
p53-Dependent induction of PVT1 and miR-1204.
Konrad Huppi; Jason J Pitt; Brady M Wahlberg; Natasha J Caplen
The 8q24 gene desert: an oasis of non-coding transcriptional activity.

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All Publications

2013: Jordi Camps; Natasha J Caplen; Chanelle M Case; Michael J Difilippantonio; Georg Emons; B Michael Ghadimi; Marian Grade; Amanda B Hummon; Tamara L Jones; Quang T Nguyen; Jason J Pitt; Tim Beissbarth; Thomas Ried
Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer.
Cancer research 2013;73(6):2003-13.
2012: Anthony M Barsotti; Rachel Beckerman; Natasha J Caplen; Konrad Huppi; Oleg Laptenko; Carol Prives
p53-Dependent induction of PVT1 and miR-1204.
The Journal of biological chemistry 2012;287(4):2509-19.
2012: Konrad Huppi; Jason J Pitt; Brady M Wahlberg; Natasha J Caplen
The 8q24 gene desert: an oasis of non-coding transcriptional activity.
Frontiers in genetics 2012;3():69.
2012: Amanda B Hummon; Konrad Huppi; Tamara L Jones; Frank Kramer; Jason J Pitt; Thomas Ried; Susan B Skube; Tim Beissbarth; Jordi Camps; Michael J Difilippantonio; Georg Emons; Marian Grade; Natasha J Caplen
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
Molecular cancer 2012;11():1.
2011: Mark Mackiewicz; Jason J Pitt; Stefan Ambs; Tiffany H Dorsey; Konrad Huppi; Natasha J Caplen
Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA.
Breast cancer research and treatment 2011;130(2):663-79.
2011: S E Martin; S Miyamoto; Yves Pommier; Z-H Wu; Y-W Zhang; Kristen S Gehlhaus; R Guha; T L Jones; Natasha J Caplen
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.
Current cancer drug targets 2011;11(8):976-86.
2011: Konrad Huppi; Jason Pitt; Brady Wahlberg; Natasha J Caplen
Genomic instability and mouse microRNAs.
Toxicology mechanisms and methods 2011;21(4):325-33.
2011: Marian Grade; Amanda B Hummon; Jordi Camps; Georg Emons; Melanie Spitzner; Jochen Gaedcke; Patrick Hoermann; Reinhard Ebner; Heinz Becker; Michael J Difilippantonio; B Michael Ghadimi; Tim Beissbarth; Natasha J Caplen; Thomas Ried
A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.
International journal of cancer. Journal international du cancer 2011;128(5):1069-79.
2010: Lyndsay M Murrow; Sireesha V Garimella; Tamara L Jones; Natasha J Caplen; Stan Lipkowitz
Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome.
Breast cancer research and treatment 2010;122(2):347-57.
2009: Andrew G Jobson; George T Lountos; Philip L Lorenzi; Jenny Llamas; John Connelly; David Cerna; Joseph E Tropea; Akikazu Onda; Gabriele Zoppoli; Sudhir Kondapaka; Guangtao Zhang; Natasha J Caplen; John H Cardellina; Stephen S Yoo; Anne Monks; Christopher Self; David S Waugh; Robert H Shoemaker; Yves Pommier
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
The Journal of pharmacology and experimental therapeutics 2009;331(3):816-26.
2009: Yong-Wei Zhang; Tamara L Jones; Scott E Martin; Natasha J Caplen; Yves Pommier
Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response.
The Journal of biological chemistry 2009;284(27):18085-95.
2008: Riko D Klootwijk; Paul J Savelkoul; Carla Ciccone; Irini Manoli; Natasha J Caplen; Donna Krasnewich; William A Gahl; Marjan Huizing
Allele-specific silencing of the dominant disease allele in sialuria by RNA interference.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(11):3846-52.
2008: Anna Maria Calcagno; Jennifer Fostel; K K W To; C D Salcido; S E Martin; K J Chewning; Chung-Pu Wu; Lyuba Varticovski; Susan E Bates; Natasha J Caplen; Suresh V Ambudkar
Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.
British journal of cancer 2008;98(9):1515-24.
2008: Konrad Huppi; Natalia Volfovsky; Timothy Runfola; Tamara L Jones; Mark Mackiewicz; Scott E Martin; J Frederic Mushinski; Robert Stephens; Natasha J Caplen
The identification of microRNAs in a genomically unstable region of human chromosome 8q24.
Molecular cancer research : MCR 2008;6(2):212-21.
2008: Michael C Ryan; Barry R Zeeberg; Natasha J Caplen; James A Cleland; Ari Kahn; Hongfang Liu; John N Weinstein
SpliceCenter: a suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies.
BMC bioinformatics 2008;9():313.
2008: Gabriele Beck-Engeser; Amy M Lum; Konrad Huppi; Natasha J Caplen; Bruce B Wang; Matthias Wabl
Pvt1-encoded microRNAs in oncogenesis.
Retrovirology 2008;5():4.
2007: Konrad Huppi; Natalia Volfovsky; Mark Mackiewicz; Timothy Runfola; Tamara L Jones; Scott E Martin; Robert Stephens; Natasha J Caplen
MicroRNAs and genomic instability.
Seminars in cancer biology 2007;17(1):65-73.
2007: Scott E Martin; Natasha J Caplen
Applications of RNA interference in mammalian systems.
Annual review of genomics and human genetics 2007;8():81-108.
2007: Scott E Martin; Tamara L Jones; Cheryl L Thomas; Philip L Lorenzi; Dac A Nguyen; Timothy Runfola; Michele Gunsior; John N Weinstein; Paul Goldsmith; Eric Lader; Konrad Huppi; Natasha J Caplen
Multiplexing siRNAs to compress RNAi-based screen size in human cells.
Nucleic acids research 2007;35(8):e57.
2006: Philip L Lorenzi; William C Reinhold; Martina Rudelius; Michele Gunsior; Uma Shankavaram; Kimberly J Bussey; Uwe Scherf; Gabriel S Eichler; Scott E Martin; Koei Chin; Joe Gray; Elise C Kohn; Ivan D Horak; Daniel Von Hoff; Mark Raffeld; Paul Goldsmith; Natasha J Caplen; John N Weinstein
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
Molecular cancer therapeutics 2006;5(11):2613-23.
2006: Scott E Martin; Natasha J Caplen
Mismatched siRNAs downregulate mRNAs as a function of target site location.
FEBS letters 2006;580(15):3694-8.
2006: Joseph A Ludwig; Gergely Szakács; Scott E Martin; Benjamin F Chu; Carol Cardarelli; Zuben Sauna; Natasha J Caplen; Henry M Fales; Suresh V Ambudkar; John N Weinstein; Michael M Gottesman
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.
Cancer research 2006;66(9):4808-15.
2006: Nozomu Yanaihara; Natasha J Caplen; Elise Bowman; Masahiro Seike; Kensuke Kumamoto; Ming Yi; Robert M Stephens; Aikou Okamoto; Jun Yokota; Tadao Tanaka; George A Calin; Chang-gong liu; Carlo M Croce; Curtis C Harris
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.
Cancer cell 2006;9(3):189-98.
2006: Uta Griesenbach; Chris Kitson; Sara Escudero Garcia; Raymond Farley; Charanjit Singh; Luci Somerton; Hazel Painter; Rbecca L Smith; Deborah R Gill; Stephen C Hyde; Yu-Hua Chow; Jim Hu; Mike Gray; Mark Edbrooke; Varrie Ogilvie; Gordon MacGregor; Ronald K Scheule; Seng Cheng; Natasha J Caplen; Eric W F W Alton
Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.
Respiratory research 2006;7():26.
2005: Chava Kimchi-Sarfaty; Scott Brittain; Susan H Garfield; Natasha J Caplen; Qingquan Tang; Michael M Gottesman
Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions.
Human gene therapy 2005;16(9):1110-5.
2005: Derek Dombroski; Richard A Houghtling; Christine M Labno; Patricia Precht; Aya Takesono; Natasha J Caplen; Daniel D Billadeau; Ronald L Wange; Janis Burkhardt; Pamela L Schwartzberg
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1385-92.
2005: Konrad Huppi; Scott E Martin; Natasha J Caplen
Defining and assaying RNAi in mammalian cells.
Molecular cell 2005;17(1):1-10.
2004: Natasha J Caplen
Gene therapy progress and prospects. Downregulating gene expression: the impact of RNA interference.
Gene therapy 2004;11(16):1241-8.
2004: Natasha J Caplen
RNAi quashes polyQ.
Nature medicine 2004;10(8):775-6.
2004: Takashi Okada; Natasha J Caplen; W Jay Ramsey; Masafumi Onodera; Kuniko Shimazaki; Tatsuya Nomoto; Rahim Ajalli; Oliver Wildner; John Morris; Akihiro Kume; Hirofumi Hamada; R. Michael Blaese; Keiya Ozawa
In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.
The journal of gene medicine 2004;6(3):288-99.
2004: Peter C Scacheri; Orit Rozenblatt-Rosen; Natasha J Caplen; Tyra G Wolfsberg; Lowell Umayam; Jeffrey C Lee; Christina M Hughes; Kalai Selvi Shanmugam; Arindam Bhattacharjee; Matthew Meyerson; Francis S Collins
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1892-7.
2003: Natasha J Caplen; Spyro Mousses
Short interfering RNA (siRNA)-mediated RNA interference (RNAi) in human cells.
Annals of the New York Academy of Sciences 2003;1002():56-62.
2003: Spyro Mousses; Natasha J Caplen; Robert Cornelison; Don Weaver; Mark Basik; Sampsa Hautaniemi; Abdel G Elkahloun; Roberto A Lotufo; Ashish Choudary; Edward R Dougherty; Ed Suh; Olli Kallioniemi
RNAi microarray analysis in cultured mammalian cells.
Genome research 2003;13(10):2341-7.
2003: Natasha J Caplen
RNAi as a gene therapy approach.
Expert opinion on biological therapy 2003;3(4):575-86.
2002: Natasha J Caplen; Zhili Zheng; Barry Falgout; Richard A Morgan
Inhibition of viral gene expression and replication in mosquito cells by dsRNA-triggered RNA interference.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):243-51.
2002: Natasha J Caplen
A new approach to the inhibition of gene expression.
Trends in biotechnology 2002;20(2):49-51.
2002: Natasha J Caplen; J. Paul Taylor; Victoria S Statham; Fumiaki Tanaka; Andrew Fire; Richard A Morgan
Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference.
Human molecular genetics 2002;11(2):175-84.
2001: Natasha J Caplen; Susan Parrish; F Imani; Andrew Fire; Richard A Morgan
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9742-7.
2000: Natasha J Caplen; Jamie Fleenor; Andrew Fire; Richard A Morgan
dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference.
Gene 2000;252(1-2):95-105.
2000: Natasha J Caplen
Nucleic acid transfer using cationic lipids.
Methods in molecular biology (Clifton, N.J.) 2000;133():1-19.
1999: Natasha J Caplen; James N Higginbotham; J R Scheel; NN Vahanian; Y Yoshida; H Hamada; R. Michael Blaese; W Jay Ramsey
Adeno-retroviral chimeric viruses as in vivo transducing agents.
Gene therapy 1999;6(3):454-9.
1998: Natasha J Caplen
Gene therapy: different strategies for different applications. American Society of Gene Therapy: First Annual Meeting, Seattle, Washington, USA, 28-31 May 1998.
Molecular medicine today 1998;4(9):374-5.
1998: W Jay Ramsey; Natasha J Caplen; Q Li; James N Higginbotham; M Shah; R. Michael Blaese
Adenovirus vectors as transcomplementing templates for the production of replication defective retroviral vectors.
Biochemical and biophysical research communications 1998;246(3):912-9.
1998: Myra Stern; FL Sorgi; C Hughes; Natasha J Caplen; JE Browning; Peter G Middleton; Dieter C Gruenert; S J Farr; L Huang; Duncan M Geddes; Eric W F W Alton
The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro.
Gene therapy 1998;5(5):583-93.
1998: Myra Stern; Natasha J Caplen; JE Browning; Uta Griesenbach; FL Sorgi; L Huang; Dieter C Gruenert; C Marriot; R G Crystal; Duncan M Geddes; Eric W F W Alton
The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro.
Gene therapy 1998;5(1):91-8.
1997: Jane C Davies; Myra Stern; A Dewar; Natasha J Caplen; Felix M Munkonge; Tyrone L Pitt; FL Sorgi; L Huang; Andrew Bush; Duncan M Geddes; Eric W F W Alton
CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium.
American journal of respiratory cell and molecular biology 1997;16(6):657-63.
1997: D Li; D Wang; S Majumdar; B Jany; S R Durham; J Cottrell; Natasha J Caplen; D M Geddes; E W Alton; P K Jeffery
Localization and up-regulation of mucin (MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis.
The Journal of pathology 1997;181(3):305-10.
1995: Myra Stern; F M Munkonge; Natasha J Caplen; FL Sorgi; L Huang; Duncan M Geddes; Eric W F W Alton
Quantitative fluorescence measurements of chloride secretion in native airway epithelium from CF and non-CF subjects.
Gene therapy 1995;2(10):766-74.
1995: Natasha J Caplen; E Kinrade; FL Sorgi; X Gao; Dieter C Gruenert; D Geddes; Charles Coutelle; L Huang; Eric W F W Alton; R Williamson
In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE.
Gene therapy 1995;2(9):603-13.
1995: Stephen N Smith; D M Steel; Peter G Middleton; F M Munkonge; Duncan M Geddes; Natasha J Caplen; David J Porteous; Julia R Dorin; Eric W F W Alton
Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans.
The American journal of physiology 1995;268(2 Pt 1):C297-307.
1995: Natasha J Caplen; Eric W F W Alton; Peter G Middleton; Julia R Dorin; B J Stevenson; X Gao; S R Durham; Peter K Jeffery; M E Hodson; Charles Coutelle
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.
Nature medicine 1995;1(1):39-46.
1994: Peter G Middleton; Natasha J Caplen; X Gao; L Huang; H Gaya; Duncan M Geddes; Eric W F W Alton
Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(3):442-5.
1994: Natasha J Caplen; X Gao; P Hayes; R Elaswarapu; G Fisher; E Kinrade; A Chakera; J Schorr; B Hughes; Julia R Dorin
Gene therapy for cystic fibrosis in humans by liposome-mediated DNA transfer: the production of resources and the regulatory process.
Gene therapy 1994;1(2):139-47.
1993: Eric W F W Alton; Peter G Middleton; Natasha J Caplen; Stephen N Smith; D M Steel; F M Munkonge; Peter K Jeffery; Duncan M Geddes; Stephen Hart; R Williamson
Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice.
Nature genetics 1993;5(2):135-42.
1993: Charles Coutelle; Natasha J Caplen; S Hart; Clare Huxley; R Williamson
Gene therapy for cystic fibrosis.
Archives of disease in childhood 1993;68(4):437-40.
1992: Eric W F W Alton; Natasha J Caplen; D Geddes; R Williamson
New treatments for cystic fibrosis.
British medical bulletin 1992;48(4):785-804.