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Timothy Stinear

Research Profile

Living Beings

Disorders

Chemicals & Drugs

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Genes & Molecular Sequences

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Vancomycin Resistance

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Publications

TOP 3
Norelle L Sherry; Timothy P Stinear; Andrew Watkins; Jessica L Porter; Torsten Seemann; Benjamin P Howden
Outbreak Investigation Using High-Throughput Genome Sequencing within a Diagnostic Microbiology Laboratory.
Wei Gao; David R Cameron; John K Davies; Xenia Kostoulias; Anton Y Peleg; Justin Stepnell; Timothy P Stinear; Kellie L Tuck; Michael R Yeaman; Benjamin P Howden
The RpoB H₄₈₁Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus.
Nicholas J Tobias; Honglei Chen; Kenneth D Doig; Volker Haring; Marnix H Medema; Robert Moore; Torsten Seemann; Timothy P Stinear
Complete genome sequence of the frog pathogen Mycobacterium ulcerans ecovar Liflandii.

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All Publications

2013: Norelle L Sherry; Timothy P Stinear; Andrew Watkins; Jessica L Porter; Torsten Seemann; Benjamin P Howden
Outbreak Investigation Using High-Throughput Genome Sequencing within a Diagnostic Microbiology Laboratory.
Journal of clinical microbiology 2013;51(5):1396-401.
2013: Wei Gao; David R Cameron; John K Davies; Xenia Kostoulias; Anton Y Peleg; Justin Stepnell; Timothy P Stinear; Kellie L Tuck; Michael R Yeaman; Benjamin P Howden
The RpoB H₄₈₁Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus.
The Journal of infectious diseases 2013;207(6):929-39.
2013: Nicholas J Tobias; Honglei Chen; Kenneth D Doig; Volker Haring; Marnix H Medema; Robert Moore; Torsten Seemann; Timothy P Stinear
Complete genome sequence of the frog pathogen Mycobacterium ulcerans ecovar Liflandii.
Journal of bacteriology 2013;195(3):556-64.
2012: Arek K Rainczuk; Torsten Seemann; Timothy P Stinear; Yoshiki Yamaryo-Botte; Rajini Brammananth; Ross L Coppel; Malcolm J McConville; PK Crellin
The lipoprotein LpqW is essential for the mannosylation of periplasmic glycolipids in Corynebacteria.
The Journal of biological chemistry 2012;287(51):42726-38.
2012: Margaret M C Lam; Robert J Moore; Torsten Seemann; Susan Ballard; Dieter Bulach; Honglei Chen; Simon L Gladman; M Lindsay Grayson; Volker Haring; Benjamin P Howden; Paul D R Johnson; Timothy P Stinear
Comparative analysis of the first complete Enterococcus faecium genome.
Journal of bacteriology 2012;194(9):2334-41.
2012: Geoffrey W Coombs; Ralf Ehricht; Richard V Goering; Benjamin P Howden; Stefan Monecke; Frances G O'Brien; Timothy P Stinear; Kyra Y L Chua; Keryn J Christiansen
The molecular epidemiology of the highly virulent ST93 Australian community Staphylococcus aureus strain.
PloS one 2012;7(8):e43037.
2012: Kenneth D Doig; Miriam Eddyani; Janet Fyfe; Kathryn E Holt; Caroline J Lavender; Gerd Pluschke; Françoise Portaels; Torsten Seemann; Dorothy Yeboah-Manu; Timothy P Stinear
On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer.
BMC genomics 2012;13():258.
2011: Benjamin P Howden; Christopher R E McEvoy; Jessica L Porter; Roy M Robins-Browne; Torsten Seemann; David L Allen; Jan Bell; Vicki Bennett-Wood; Kyra Chua; Geoffrey Coombs; John K Davies; Wei Gao; Paul F Harrison; Timothy P Stinear
Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR.
PLoS pathogens 2011;7(11):e1002359.
2011: Kyra Y L Chua; Geoffrey W Coombs; John K Davies; Paul F Harrison; Brian O Howden; Benjamin P Howden; Paul D R Johnson; Tony M Korman; Shaun Monagle; Torsten Seemann; Timothy P Stinear
The dominant Australian community-acquired methicillin-resistant Staphylococcus aureus clone ST93-IV [2B] is highly virulent and genetically distinct.
PloS one 2011;6(10):e25887.
2010: Sacha J Pidot; Jessica L Porter; Nicholas J Tobias; Jeffrey Anderson; Deanne Catmull; Torsten Seemann; Stephen Kidd; John K Davies; Eric Reynolds; Stuart Dashper; Timothy P Stinear
Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation.
Molecular microbiology 2010;78(5):1216-31.
2010: Benjamin P Howden; Torsten Seemann; Paul F Harrison; Chris R McEvoy; Jo-Ann L Stanton; Christy J Rand; Chris W Mason; Slade O Jensen; Neville Firth; John K Davies; Paul Johnson; Timothy P Stinear
Complete genome sequence of Staphylococcus aureus strain JKD6008, an ST239 clone of methicillin-resistant Staphylococcus aureus with intermediate-level vancomycin resistance.
Journal of bacteriology 2010;192(21):5848-9.
2010: Kyra Chua; Torsten Seemann; Paul F Harrison; John K Davies; Scott J Coutts; Honglei Chen; Volker Haring; Robert Moore; Benjamin P Howden; Timothy P Stinear
Complete genome sequence of Staphylococcus aureus strain JKD6159, a unique Australian clone of ST93-IV community methicillin-resistant Staphylococcus aureus.
Journal of bacteriology 2010;192(20):5556-7.
2010: Sacha J Pidot; Jessica L Porter; Laurent Marsollier; Annick Chauty; Florence Migot-Nabias; cyril badaut; Angèle Bénard; Marie-Therese Ruf; Torsten Seemann; Paul Johnson; John K Davies; Grant A Jenkin; Gerd Pluschke; Timothy P Stinear
Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics.
PLoS neglected tropical diseases 2010;4(11):e872.
2010: Janet Fyfe; Caroline J Lavender; Kathrine A Handasyde; Alistair R Legione; Carolyn O'Brien; Timothy P Stinear; Sacha J Pidot; Torsten Seemann; M Eric Benbow; John R Wallace; Christina McCowan; Paul Johnson
A major role for mammals in the ecology of Mycobacterium ulcerans.
PLoS neglected tropical diseases 2010;4(8):e791.
2010: Sacha J Pidot; Kingsley Asiedu; Michael Käser; Janet A M Fyfe; Timothy P Stinear
Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species.
PLoS neglected tropical diseases 2010;4(7):e663.
2010: Wei Gao; Kyra Chua; John K Davies; Hayley Newton; Torsten Seemann; Paul F Harrison; Natasha E Holmes; Hyun-Woo Rhee; Jong-In Hong; Elizabeth L Hartland; Timothy P Stinear; Benjamin P Howden
Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.
PLoS pathogens 2010;6(6):e1000944.
2010: Benjamin P Howden; John K Davies; Paul Johnson; Timothy P Stinear; M Lindsay Grayson
Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications.
Clinical microbiology reviews 2010;23(1):99-139.
2009: Jessica L Porter; Nicholas J Tobias; Hui Hong; Kellie L Tuck; Grant A Jenkin; Timothy P Stinear
Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum.
Microbiology (Reading, England) 2009;155(Pt 6):1923-33.
2009: Stephen V Gordon; Daria Bottai; Roxane Simeone; Timothy P Stinear; Roland Brosch
Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants.
BioEssays : news and reviews in molecular, cellular and developmental biology 2009;31(4):378-88.
2009: Nicholas J Tobias; Torsten Seemann; Sacha J Pidot; Jessica L Porter; Laurent Marsollier; Estelle Marion; Franck Letournel; Tasnim Zakir; Joseph Azuolas; John R Wallace; Hui Hong; John K Davies; Benjamin P Howden; Paul Johnson; Grant A Jenkin; Timothy P Stinear
Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.
PLoS neglected tropical diseases 2009;3(11):e553.
2008: Caroline J Lavender; Timothy P Stinear; Paul Johnson; Joseph Azuolas; Mark Eric Benbow; John R Wallace; Janet Fyfe
Evaluation of VNTR typing for the identification of Mycobacterium ulcerans in environmental samples from Victoria, Australia.
FEMS microbiology letters 2008;287(2):250-5.
2008: Benjamin P Howden; Timothy P Stinear; David L Allen; Paul Johnson; Peter B Ward; John K Davies
Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2008;52(10):3755-62.
2008: Petra Tafelmeyer; Christine Laurent; Pascal Lenormand; Jean-Claude Rousselle; Laurent Marsollier; Gilles Reysset; Runxuan Zhang; Albert Sickmann; Timothy P Stinear; Abdelkader Namane; Stewart T Cole
Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis.
Proteomics 2008;8(15):3124-38.
2008: Hui Hong; Caroline Demangel; Sacha J Pidot; Peter F Leadlay; Timothy P Stinear
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria.
Natural product reports 2008;25(3):447-54.
2008: Sacha J Pidot; Hui Hong; Torsten Seemann; Jessica L Porter; Marcus J Yip; Artem Men; Matthew Johnson; Peter Wilson; John K Davies; Peter F Leadlay; Timothy P Stinear
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.
BMC genomics 2008;9():462.
2008: Timothy P Stinear; Paul Johnson
First isolation of Mycobacterium ulcerans from an aquatic environment: the end of a 60-year search?
PLoS neglected tropical diseases 2008;2(3):e216.
2008: Benjamin P Howden; Danielle J Smith; Ashley Mansell; Paul Johnson; Peter B Ward; Timothy P Stinear; John K Davies
Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia.
BMC microbiology 2008;8():39.
2007: Hui Hong; Timothy P Stinear; Jessica Porter; Caroline Demangel; Peter F Leadlay
A novel mycolactone toxin obtained by biosynthetic engineering.
Chembiochem : a European journal of chemical biology 2007;8(17):2043-7.
2007: Paul Johnson; Joseph Azuolas; Caroline J Lavender; Elwyn Wishart; Timothy P Stinear; John A Hayman; Lynne Brown; Grant A Jenkin; Janet Fyfe
Mycobacterium ulcerans in mosquitoes captured during outbreak of Buruli ulcer, southeastern Australia.
Emerging infectious diseases 2007;13(11):1653-60.
2007: Janet Fyfe; Caroline J Lavender; Paul Johnson; Maria Globan; Aina Sievers; Joseph Azuolas; Timothy P Stinear
Development and application of two multiplex real-time PCR assays for the detection of Mycobacterium ulcerans in clinical and environmental samples.
Applied and environmental microbiology 2007;73(15):4733-40.
2007: Simona Rondini; Michael Käser; Timothy P Stinear; Michel Tessier; Cyrill Mangold; Gregor Dernick; Martin Naegeli; Françoise Portaels; Ulrich Certa; Gerd Pluschke
Ongoing genome reduction in Mycobacterium ulcerans.
Emerging infectious diseases 2007;13(7):1008-15.
2007: Markus Hilty; Michael Käser; Jakob Zinsstag; Timothy P Stinear; Gerd Pluschke
Analysis of the Mycobacterium ulcerans genome sequence reveals new loci for variable number tandem repeats (VNTR) typing.
Microbiology (Reading, England) 2007;153(Pt 5):1483-7.
2007: Marcus J Yip; Jessica L Porter; Janet Fyfe; Caroline J Lavender; Françoise Portaels; Martha Rhodes; Howard Kator; Angelo Colorni; Grant A Jenkin; Timothy P Stinear
Evolution of Mycobacterium ulcerans and other mycolactone-producing mycobacteria from a common Mycobacterium marinum progenitor.
Journal of bacteriology 2007;189(5):2021-9.
2007: Timothy P Stinear; Torsten Seemann; Sacha Pidot; Wafa Frigui; Gilles Reysset; Thierry Garnier; Guillaume Meurice; David Simon; Christiane Bouchier; Laurence Ma; Magali Tichit; Jessica L Porter; Janine Ryan; Paul Johnson; John K Davies; Grant A Jenkin; Pamela L C Small; Louis M Jones; Fredj Tekaia; Françoise Laval; Mamadou Daffé; Julian Parkhill; Stewart T Cole
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.
Genome research 2007;17(2):192-200.
2007: Caroline J Lavender; Sanjaya N Senanayake; Janet Fyfe; John A Buntine; Maria Globan; Timothy P Stinear; John A Hayman; Paul Johnson
First case of Mycobacterium ulcerans disease (Bairnsdale or Buruli ulcer) acquired in New South Wales.
The Medical journal of Australia 2007;186(2):62-3.
2007: Michael Käser; Simona Rondini; Martin Naegeli; Timothy P Stinear; Françoise Portaels; Ulrich Certa; Gerd Pluschke
Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans.
BMC evolutionary biology 2007;7():177.
2006: Benjamin P Howden; Paul Johnson; Peter B Ward; Timothy P Stinear; John K Davies
Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia.
Antimicrobial agents and chemotherapy 2006;50(9):3039-47.
2005: Hui Hong; Timothy P Stinear; Paul Skelton; Jonathan B Spencer; Peter F Leadlay
Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.
Chemical communications (Cambridge, England) 2005;(34):4306-8.
2005: Paul Johnson; Timothy P Stinear; Pamela L C Small; Gerd Pluschke; Richard W Merritt; Françoise Portaels; Kris Huygen; John A Hayman; Kingsley Asiedu
Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control.
PLoS medicine 2005;2(4):e108.
2005: Hui Hong; Jonathan B Spencer; Jessica L Porter; Peter F Leadlay; Timothy P Stinear
A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.
Chembiochem : a European journal of chemical biology 2005;6(4):643-8.
2005: Timothy P Stinear; Melinda J Pryor; Jessica L Porter; Stewart T Cole
Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans.
Microbiology (Reading, England) 2005;151(Pt 3):683-92.
2005: Timothy P Stinear; Hui Hong; Wafa Frigui; Melinda J Pryor; Roland Brosch; Thierry Garnier; Peter F Leadlay; Stewart T Cole
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans.
Journal of bacteriology 2005;187(5):1668-76.
2004: Timothy P Stinear; Armand Mve-Obiang; Pamela L C Small; Wafa Frigui; Melinda J Pryor; Roland Brosch; Grant A Jenkin; Paul Johnson; John K Davies; Richard E Lee; Sarojini Adusumilli; Thierry Garnier; Stephen F Haydock; Peter F Leadlay; Stewart T Cole
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1345-9.
2004: Laurent Marsollier; Timothy P Stinear; Jacques Aubry; Jean-Paul Saint-André; Raymond Robert; Pierre Legras; Anne-Lise Manceau; Christine Audrain; Sandra Bourdon; Henri Kouakou; Bernard Carbonnelle
Aquatic plants stimulate the growth of and biofilm formation by Mycobacterium ulcerans in axenic culture and harbor these bacteria in the environment.
Applied and environmental microbiology 2004;70(2):1097-103.
2003: Grant A Jenkin; Timothy P Stinear; Paul Johnson; John K Davies
Subtractive hybridization reveals a type I polyketide synthase locus specific to Mycobacterium ulcerans.
Journal of bacteriology 2003;185(23):6870-82.
2003: Hui Hong; Paul J Gates; James Staunton; Timothy P Stinear; Stewart T Cole; Peter F Leadlay; Jonathan B Spencer
Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.
Chemical communications (Cambridge, England) 2003;(22):2822-3.
2003: Tjip S van der Werf; Timothy P Stinear; Ymkje Stienstra; Winette T A van der Graaf; Pamela L C Small
Mycolactones and Mycobacterium ulcerans disease.
Lancet 2003;362(9389):1062-4.
2001: Timothy P Stinear; Di Olden; Paul Johnson; John K Davies; M L Grayson
Enterococcal vanB resistance locus in anaerobic bacteria in human faeces.
Lancet 2001;357(9259):855-6.
2000: Timothy P Stinear; Grant A Jenkin; Paul Johnson; John K Davies
Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence.
Journal of bacteriology 2000;182(22):6322-30.
2000: Timothy P Stinear; John K Davies; Grant A Jenkin; John A Hayman; Frances Oppedisano; Paul Johnson
Identification of Mycobacterium ulcerans in the environment from regions in Southeast Australia in which it is endemic with sequence capture-PCR.
Applied and environmental microbiology 2000;66(8):3206-13.
2000: Timothy P Stinear; John K Davies; Grant A Jenkin; Françoise Portaels; BC Ross; Frances Oppedisano; M Purcell; John A Hayman; Paul Johnson
A simple PCR method for rapid genotype analysis of Mycobacterium ulcerans.
Journal of clinical microbiology 2000;38(4):1482-7.
1999: Paul Johnson; Timothy P Stinear; John A Hayman
Mycobacterium ulcerans--a mini-review.
Journal of medical microbiology 1999;48(6):511-3.
1999: Timothy P Stinear; BC Ross; John K Davies; L Marino; Roy M Robins-Browne; Frances Oppedisano; A Sievers; Paul Johnson
Identification and characterization of IS2404 and IS2606: two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR.
Journal of clinical microbiology 1999;37(4):1018-23.
1997: BC Ross; Paul Johnson; Frances Oppedisano; L Marino; A Sievers; Timothy P Stinear; John A Hayman; M G Veitch; Roy M Robins-Browne
Detection of Mycobacterium ulcerans in environmental samples during an outbreak of ulcerative disease.
Applied and environmental microbiology 1997;63(10):4135-8.