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Kenneth Aldape

Research Profile

Disorders

Chemicals & Drugs

Living Beings

Anatomy

Tumor Cell Line

Physiology

Gene Expression Regulation, Neoplastic

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Oligonucleotide Array Sequence Analysis

Genes & Molecular Sequences

Genes, p53

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Publications

TOP 3
Khatri Latha; Ming Li; Raymond Sawaya; Anupama Gururaj; YeoHyeon Hwang; Kenneth Aldape; Oliver Bogler; Webster K Cavenee; Vaibhav Chumbalkar; Sumana Dakeng; Frank B Furnari
Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter.
Weiwei Yang; M James You; Lin Zhang; Yanhua Zheng; Inder M Verma; Yan Xia; Kenneth Aldape; Wen Bu; Yu Cao; Paul J Chiao; Gilbert Cote; Mei Yee Koh; Yi Li; Zhimin Lu
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Weiwei Yang; Yanhua Zheng; Costas A Lyssiotis; Yan Xia; Kenneth Aldape; Lewis C Cantley; Xiaomin Chen; Fang Guo; Haitao Ji; Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

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All Publications

2013: Khatri Latha; Ming Li; Raymond Sawaya; Anupama Gururaj; YeoHyeon Hwang; Kenneth Aldape; Oliver Bogler; Webster K Cavenee; Vaibhav Chumbalkar; Sumana Dakeng; Frank B Furnari
Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter.
International journal of cancer. Journal international du cancer 2013;132(3):509-20.
2012: Weiwei Yang; M James You; Lin Zhang; Yanhua Zheng; Inder M Verma; Yan Xia; Kenneth Aldape; Wen Bu; Yu Cao; Paul J Chiao; Gilbert Cote; Mei Yee Koh; Yi Li; Zhimin Lu
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Molecular cell 2012;48(5):771-84.
2012: Weiwei Yang; Yanhua Zheng; Costas A Lyssiotis; Yan Xia; Kenneth Aldape; Lewis C Cantley; Xiaomin Chen; Fang Guo; Haitao Ji; Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Nature cell biology 2012;14(12):1295-304.
2012: Weiwei Yang; Yan Xia; Dongming Xing; Kenneth Aldape; W K Alfred Yung; David Hawke; Tony Hunter; Xinjian Li; Ji Liang; Zhimin Lu
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
Cell 2012;150(4):685-96.
2012: Ke Sai; Slawomir Szymanski; Shuzhen Wang; Kenneth Aldape; W K Alfred Yung; Veerakumar Balasubramaniyan; Zhongping Chen; Charles Conrad; Atreyi Dasgupta; Izabela Fokt; Su Guan; Frederick F Lang; Timothy Madden; Waldemar Priebe; Latif Shooshtari Nasrin
Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway.
Journal of neuro-oncology 2012;107(3):487-501.
2012: Jennifer Molina; Fabiana C Morales; Y Hayashi; N K Agarwal; Kenneth Aldape; G Cote; Maria-Magdalena Georgescu
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.
Oncogene 2012;31(10):1264-74.
2012: Scott E Woodman; Alexander J Lazar; Kenneth Aldape; Michael A Davies
New strategies in melanoma: molecular testing in advanced disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(5):1195-200.
2011: Weiwei Yang; Yanhua Zheng; Yan Xia; Kenneth Aldape; Xiang Gao; Wenhua Huang; Haitao Ji; Ji Liang; Zhimin Lu
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Nature 2011;480(7375):118-22.
2011: Jennifer L Clarke; Michele M Ennis; Lauren Abrey; Kenneth Aldape; Susan M Chang; Timothy F Cloughesy; Lisa M Deangelis; Howard A Fine; Mark R Gilbert; John Kuhn; Kathleen R Lamborn; Frank S Lieberman; Minesh Mehta; Michael D Prados; H Ian Robins; Patrick Y Wen; W K Alfred Yung
Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma?
Neuro-oncology 2011;13(10):1118-24.
2011: Melissa M Singh; Wen-Wei Tsai; Christa A Manton; Kenneth Aldape; Michelle Craig Barton; Krishna P Bhat; Joya Chandra
Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors.
Neuro-oncology 2011;13(8):894-903.
2011: Wen-Tai Chiu; Cheng-Yang Chou; Feng-Ju Huang; Hsueh-Te Lee; Zhimin Lu; Patricia S Steeg; Keping Xie; Jun Yao; Kenneth Aldape; Suyun Huang
Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.
Cancer research 2011;71(14):4932-43.
2011: John F de Groot; Lisa De Angelis; Mark R Gilbert; Edward F Jackson; Kathleen R Lamborn; Andrew B Lassman; Frank S Lieberman; Minesh Mehta; Michael D Prados; H Ian Robins; Kenneth Aldape; Susan M Chang; Alice Chen; Timothy F Cloughesy; Jun Yao; W K Alfred Yung; Patrick Y Wen
Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(19):2689-95.
2011: Dongmin Gu; Faith Hollingsworth; Hong Ji; Moonsup Lee; Kenneth Aldape; Krishna P Bhat; Maria A Schumacher; Nam Ky Tonthat; Thomas P Zwaka; Pierre D McCrea
Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.
The Journal of biological chemistry 2011;286(26):23178-88.
2011: Terri S. Armstrong; Sujit Prabhu; Kenneth Aldape; Betsy Hossan; Sanghee Kang; Amanda Childress; Lori Tolentino; Mark R Gilbert
A case of soft tissue metastasis from glioblastoma and review of the literature.
Journal of neuro-oncology 2011;103(1):167-72.
2011: John F de Groot; Erik P Sulman; Kenneth Aldape
Multigene sets for clinical application in glioma.
Journal of the National Comprehensive Cancer Network : JNCCN 2011;9(4):449-56; quiz 457.
2011: David Cogdell; Woonbok Chung; Yuexin Liu; J Matthew McDonald; Kenneth Aldape; Jean-Pierre J Issa; Gregory N Fuller; Wei Zhang
Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma.
Chinese journal of cancer 2011;30(4):247-53.
2011: John H Sampson; Kenneth Aldape; Gary E Archer; April Coan; Annick Desjardins; Allan H Friedman; Henry S Friedman; Mark R Gilbert; James E Herndon; Roger E McLendon; Duane A Mitchell; David A Reardon; Raymond Sawaya; Robert Schmittling; Weiming Shi; James J Vredenburgh; Darell D Bigner; Amy B Heimberger
Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma.
Neuro-oncology 2011;13(3):324-33.
2011: Markus Bredel; Denise M Scholtens; Ajay K Yadav; Angel A Alvarez; Jaclyn J Renfrow; James P Chandler; Irene L Y Yu; Maria S Carro; Fangping Dai; Michael J Tagge; Roberto Ferrarese; Claudia Bredel; Heidi S Phillips; Paul J Lukac; Pierre A Robe; Astrid Weyerbrock; Hannes Vogel; Steven Dubner; Bret Mobley; Xiaolin He; Adrienne C Scheck; Branimir I Sikic; Kenneth Aldape; Arnab Chakravarti; Griffith R Harsh
NFKBIA deletion in glioblastomas.
The New England journal of medicine 2011;364(7):627-37.
2011: Bridget J McCarthy; Kristin M Rankin; Kenneth Aldape; Melissa L Bondy; Thomas Brännström; Helle Broholm; Maria Feychting; Dora Il'yasova; Peter D Inskip; Christoffer Johansen; Beatrice S Melin; Avima Ruder; Mary Ann Butler; Michael Scheurer; Joachim Schüz; Judith A Schwartzbaum; Margaret Wrensch; Faith G Davis
Risk factors for oligodendroglial tumors: a pooled international study.
Neuro-oncology 2011;13(2):242-50.
2011: Y Liu; F Lang; X Xie; S Prabhu; J Xu; D Sampath; Kenneth Aldape; G Fuller; V K Puduvalli
Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts.
Cell death & disease 2011;2():e121.
2011: Erik P Sulman; Kenneth Aldape
The use of global profiling in biomarker development for gliomas.
Brain pathology (Zurich, Switzerland) 2011;21(1):88-95.
2010: Dan Liu; Vanesa Martin; Juan Fueyo; Ok-Hee Lee; Jing Xu; Nahir Cortes-Santiago; Marta M Alonso; Kenneth Aldape; Latif Shooshtari Nasrin; Candelaria Gomez-Manzano
Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype.
Oncotarget 2010;1(8):700-9.
2010: Qingtang Lin; Krishnakumar Balasubramanian; Dominic Fan; Sun-Jin Kim; Lixia Guo; Hua Wang; Menashe Bar-Eli; Kenneth Aldape; Isaiah J Fidler
Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels.
Neoplasia (New York, N.Y.) 2010;12(9):748-54.
2010: J H Tchaicha; A K Mobley; M G Hossain; Kenneth Aldape; J H McCarty
A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis.
Oncogene 2010;29(31):4460-72.
2010: Ingeborg Fischer; Kenneth Aldape
Molecular tools: biology, prognosis, and therapeutic triage.
Neuroimaging clinics of North America 2010;20(3):273-82.
2010: Adam Wu; Kenneth Aldape; Frederick F Lang
High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors.
Journal of neuro-oncology 2010;99(1):57-64.
2010: Houtan Noushmehr; Daniel J Weisenberger; Kristin Diefes; Heidi S Phillips; Kanan Pujara; Benjamin P Berman; Fei Pan; Christopher E Pelloski; Erik P Sulman; Krishna P Bhat; Roel G W Verhaak; Katherine A Hoadley; D Neil Hayes; Charles M Perou; Heather K Schmidt; Li Ding; Richard K Wilson; David Van Den Berg; Hui Shen; Henrik Bengtsson; Pierre Neuvial; Leslie Cope; Jonathan Buckley; James G Herman; Stephen B Baylin; Peter W Laird; Kenneth Aldape
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
Cancer cell 2010;17(5):510-22.
2010: Yanhong Liu; Sanjay Shete; Carol J Etzel; Michael Scheurer; George Alexiou; Georgina Armstrong; Spyros Tsavachidis; Fu-Wen Liang; Mark Gilbert; Kenneth Aldape; Terri Armstrong; Richard Houlston; Fay Hosking; Lindsay Robertson; Yuanyuan Xiao; John Wiencke; Margaret Wrensch; Ulrika Andersson; Beatrice S Melin; Melissa L Bondy
Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(14):2467-74.
2010: Susan L McGovern; Kenneth Aldape; Mark F Munsell; Anita Mahajan; Franco DeMonte; Shiao Y Woo
A comparison of World Health Organization tumor grades at recurrence in patients with non-skull base and skull base meningiomas.
Journal of neurosurgery 2010;112(5):925-33.
2010: Andreana L Rivera; Christopher E Pelloski; Mark R Gilbert; Howard Colman; Clarissa De La Cruz; Erik P Sulman; B Nebiyou Bekele; Kenneth Aldape
MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma.
Neuro-oncology 2010;12(2):116-21.
2010: Bruno M Costa; Justin S Smith; Ying Chen; Justin Chen; Heidi S Phillips; Kenneth Aldape; Giuseppe Zardo; Janice M Nigro; C David James; Jane Fridlyand; Rui M Reis; Joseph F Costello
Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma.
Cancer research 2010;70(2):453-62.
2010: Jeffrey J Raizer; Lauren E Abrey; Andrew B Lassman; Susan M Chang; Kathleen R Lamborn; John Kuhn; W K Alfred Yung; Mark R Gilbert; Kenneth Aldape; Patrick Y Wen; Howard A Fine; Minesh Mehta; Lisa De Angelis; Frank Lieberman; Timothy F Cloughesy; H Ian Robins; Janet Dancey; Michael D Prados
A phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas.
Neuro-oncology 2010;12(1):87-94.
2010: Latif Shooshtari Nasrin; Li Zhang; Erik P Sulman; J Matthew McDonald; Nasrin Latif Shooshtari; Andreana Rivera; Sonya Popoff; Catherine L Nutt; David N Louis; J Gregory Cairncross; Mark R Gilbert; Heidi S Phillips; Minesh Mehta; Arnab Chakravarti; Christopher E Pelloski; Krishna Bhat; Burt G Feuerstein; Robert B Jenkins; Kenneth Aldape
A multigene predictor of outcome in glioblastoma.
Neuro-oncology 2010;12(1):49-57.
2009: haitao ji; Ji Wang; Heinz Nika; David Hawke; Susan Keezer; Qingyuan Ge; Bingliang Fang; Xuexun Fang; Dexing Fang; David W Litchfield; Kenneth Aldape; Zhimin Lu
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.
Molecular cell 2009;36(4):547-59.
2009: Christina Maria Sperduto; Arnab Chakravarti; Kenneth Aldape; Peter C Burger; Gail Bender Papermaster; Paul Sperduto
Twenty-year survival in glioblastoma: a case report and molecular profile.
International journal of radiation oncology, biology, physics 2009;75(4):1162-5.
2009: Diane Palmieri; Daniel Fitzgerald; S Martin Shreeve; Emily Hua; Julie L Bronder; Robert J Weil; Sean Davis; Andreas M Stark; Maria J Merino; Raffael Kurek; H Maximilian Mehdorn; Gary Davis; Seth M Steinberg; Paul S Meltzer; Kenneth Aldape; Patricia S Steeg
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.
Molecular cancer research : MCR 2009;7(9):1438-45.
2009: Xudong Zhao; Domenico D' Arca; Wei Keat Lim; Manisha Brahmachary; Maria Stella Carro; Thomas Ludwig; Carlos Cordon Cardo; Francois Guillemot; Kenneth Aldape; Andrea Califano; Antonio Iavarone; Anna Lasorella
The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.
Developmental cell 2009;17(2):210-21.
2009: Menghong Sun; Carmen Behrens; Lei Feng; Natalie Ozburn; Ximing Tang; Guosheng Yin; Ritsuko Komaki; Marileila Varella-Garcia; Waun Ki Hong; Kenneth Aldape; Ignacio I Wistuba
HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(15):4829-37.
2009: Stephen Yip; Jiangyong Miao; Daniel P Cahill; A John Iafrate; Kenneth Aldape; Catherine L Nutt; David N Louis
MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(14):4622-9.
2009: Yanhua Zheng; Yan Xia; David Hawke; Maxime Halle; Michel L Tremblay; Xiang Gao; Xiao Zhen Zhou; Kenneth Aldape; Melanie H Cobb; Keping Xie; Jie He; Zhimin Lu
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Molecular cell 2009;35(1):11-25.
2009: Erik P Sulman; Marisol Guerrero; Kenneth Aldape
Beyond grade: molecular pathology of malignant gliomas.
Seminars in radiation oncology 2009;19(3):142-9.
2009: Yuji Piao; Hong Jiang; Ramon Alemany; Victor Krasnykh; Frank C Marini; J Xu; Marta M Alonso; Charles A Conrad; Kenneth Aldape; Candelaria Gomez-Manzano; Juan Fueyo
Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity.
Cancer gene therapy 2009;16(3):256-65.
2009: Yanhong Liu; Michael Scheurer; Randa A el-Zein; Yumei Cao; Kim-Anh Do; Mark Gilbert; Kenneth Aldape; Qingyi Wei; Carol J Etzel; Melissa L Bondy
Association and interactions between DNA repair gene polymorphisms and adult glioma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(1):204-14.
2008: J Matthew McDonald; Christopher E Pelloski; Alicia Ledoux; Menghong Sun; Gabriela Raso; Ritsuko Komaki; Ignacio I Wistuba; B Nebiyou Bekele; Kenneth Aldape
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7832-7.
2008: Candelaria Gomez-Manzano; Jocelyn Holash; Juan Fueyo; Jing Xu; Charles A Conrad; Kenneth Aldape; John F de Groot; B Nebiyou Bekele; W K Alfred Yung
VEGF Trap induces antiglioma effect at different stages of disease.
Neuro-oncology 2008;10(6):940-5.
2008: Ingeborg Fischer; Clarissa de la Cruz; Andreana L Rivera; Kenneth Aldape
Utility of chromogenic in situ hybridization (CISH) for detection of EGFR amplification in glioblastoma: comparison with fluorescence in situ hybridization (FISH).
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2008;17(4):227-30.
2008: Michael Scheurer; E Amirian; Yumei Cao; Mark R Gilbert; Kenneth Aldape; David G Kornguth; Randa El-Zein; Melissa L Bondy
Polymorphisms in the interleukin-4 receptor gene are associated with better survival in patients with glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6640-6.
2008: John F de Groot; Mark R Gilbert; Kenneth Aldape; Kenneth R Hess; T A Hanna; Sandra Ictech; Morris D Groves; Charles Conrad; Howard Colman; Vinay K Puduvalli; Victor Levin; W K Alfred Yung
Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma.
Journal of neuro-oncology 2008;90(1):89-97.
2008: Krishna P Bhat; Christopher E Pelloski; Yujian Zhang; Se Hoon Kim; Clarissa deLaCruz; Michael Rehli; Kenneth Aldape
Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2.
FEBS letters 2008;582(21-22):3193-200.
2008: Howard Colman; Kenneth Aldape
Molecular predictors in glioblastoma: toward personalized therapy.
Archives of neurology 2008;65(7):877-83.
2008: Tong-Xin Xie; Kenneth Aldape; Weida Gong; Takao Kanzawa; Dima Suki; Seiji Kondo; Frederick Lang; Francis Ali-Osman; Raymond Sawaya; Suyun Huang
Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor.
International journal of oncology 2008;33(1):5-15.
2008: Caterina Giannini; Peter C Burger; Brian A Berkey; J Gregory Cairncross; Robert B Jenkins; Minesh Mehta; Walter Curran; Kenneth Aldape
Anaplastic oligodendroglial tumors: refining the correlation among histopathology, 1p 19q deletion and clinical outcome in Intergroup Radiation Therapy Oncology Group Trial 9402.
Brain pathology (Zurich, Switzerland) 2008;18(3):360-9.
2008: Michael Scheurer; Melissa L Bondy; Kenneth Aldape; Thomas Albrecht; Randa El-Zein
Detection of human cytomegalovirus in different histological types of gliomas.
Acta neuropathologica 2008;116(1):79-86.
2008: Shaheenah Dawood; Kristine Broglio; Francisco J Esteva; Nuhad K Ibrahim; Shu-Wan Kau; Rabiul Islam; Kenneth Aldape; Tse-Kuan Yu; Gabriel N Hortobagyi; Ana M Gonzalez-Angulo
Defining prognosis for women with breast cancer and CNS metastases by HER2 status.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(7):1242-8.
2008: Erik Sulman; Kenneth Aldape; Howard Colman
Brain tumor stem cells.
Current problems in cancer 2008;32(3):124-42.
2008: Andreana L Rivera; Christopher E Pelloski; Erik Sulman; Kenneth Aldape
Prognostic and predictive markers in glioma and other neuroepithelial tumors.
Current problems in cancer 2008;32(3):97-123.
2008: Michael Scheurer; Randa A el-Zein; Patricia A Thompson; Kenneth Aldape; Victor Levin; Mark R Gilbert; Jeffrey S Weinberg; Melissa L Bondy
Long-term anti-inflammatory and antihistamine medication use and adult glioma risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(5):1277-81.
2008: Hiroshi Aoki; Yasuko Kondo; Kenneth Aldape; Akitsugu Yamamoto; Eiji Iwado; Tomohisa Yokoyama; E Faith Hollingsworth; Ryuji Kobayashi; Kenneth Hess; Naoki Shinojima; Takashi Shingu; Yutaka Tamada; LI Zhang; Charles Conrad; Oliver Bogler; Gordon Mills; Raymond Sawaya; Seiji Kondo
Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.
Autophagy 2008;4(4):467-75.
2008: Maximilian Diehn; Christine Nardini; David S Wang; Susan McGovern; Mahesh Jayaraman; Yu Liang; Kenneth Aldape; Soonmee Cha; Michael D Kuo
Identification of noninvasive imaging surrogates for brain tumor gene-expression modules.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5213-8.
2008: Kathleen R Lamborn; W K Alfred Yung; Susan M Chang; Patrick Y Wen; Timothy F Cloughesy; Lisa De Angelis; H Ian Robins; Frank S Lieberman; Howard A Fine; Karen L Fink; Larry Junck; Lauren E Abrey; Mark R Gilbert; Minesh Mehta; John Kuhn; Kenneth Aldape; Janelle Hibberts; Pamela M Peterson; Michael D Prados
Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas.
Neuro-oncology 2008;10(2):162-70.
2008: Faith G Davis; Beatrice Malmer; Kenneth Aldape; Jill S Barnholtz-Sloan; Melissa L Bondy; Thomas Brännström; Janet M Bruner; Peter C Burger; V Peter Collins; Peter D Inskip; Carol Kruchko; Bridget J McCarthy; Roger E McLendon; Siegal Sadetzki; Tarik Tihan; Margaret Wrensch; Patricia A Buffler
Issues of diagnostic review in brain tumor studies: from the Brain Tumor Epidemiology Consortium.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(3):484-9.
2008: Amy B Heimberger; Wei Sun; S Farzana Hussain; Mahua Dey; Lamonne Crutcher; Kenneth Aldape; Mark Gilbert; Samuel J Hassenbusch; Raymond Sawaya; Bob Schmittling; Gary E Archer; Duane A Mitchell; Darell D Bigner; John H Sampson
Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study.
Neuro-oncology 2008;10(1):98-103.
2008: Pablo Freire; Marco Vilela; Helena Deus; Yong-Wan Kim; Dimpy Koul; Howard Colman; Kenneth Aldape; Oliver Bogler; W K Alfred Yung; Kevin R Coombes; Gordon B Mills; Ana T Vasconcelos; Jonas Almeida
Exploratory analysis of the copy number alterations in glioblastoma multiforme.
PloS one 2008;3(12):e4076.
2008: Hannah C Cheung; Keith A Baggerly; Spiridon Tsavachidis; Linda L Bachinski; Valerie L Neubauer; Tamara J Nixon; Kenneth Aldape; Gilbert J Cote; Ralf Krahe
Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays.
BMC genomics 2008;9():216.
2007: Monica E Loghin; Michael D Prados; Patrick Y Wen; Larry Junck; Frank S Lieberman; Howard A Fine; Karen L Fink; Minesh Metha; John Kuhn; Kathleen R Lamborn; Susan M Chang; Timothy F Cloughesy; Lisa De Angelis; Ian H Robins; Kenneth Aldape; W K Alfred Yung
Phase I study of temozolomide and irinotecan for recurrent malignant gliomas in patients receiving enzyme-inducing antiepileptic drugs: a north american brain tumor consortium study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(23):7133-8.
2007: Hiroshi Aoki; Tomohisa Yokoyama; Keishi Fujiwara; Ana M Tari; Raymond Sawaya; Dima Suki; Kenneth R Hess; Kenneth Aldape; Seiji Kondo; Rakesh Kumar; Yasuko Kondo
Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6603-9.
2007: Victor Levin; Jacob L Jochec; Lisa M Shantz; Kenneth Aldape
Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy.
International journal of cancer. Journal international du cancer 2007;121(10):2279-83.
2007: Michael Scheurer; Carol J Etzel; Mei Liu; Randa A el-Zein; Gladstone Airewele; Beatrice Malmer; Kenneth Aldape; Jeffrey S Weinberg; W K Alfred Yung; Melissa L Bondy
Aggregation of cancer in first-degree relatives of patients with glioma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(11):2491-5.
2007: Bingbing Dai; Shin-Hyuk Kang; W Gong; Mingyao Liu; Kenneth Aldape; Raymond Sawaya; Suyun Huang
Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells.
Oncogene 2007;26(42):6212-9.
2007: Chibo Hong; K Scott Moorefield; Peter Jun; Kenneth Aldape; Samir Kharbanda; Heidi S Phillips; Joseph F Costello
Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10974-9.
2007: Christopher E Pelloski; Karla V Ballman; Alfred F Furth; LI Zhang; E Lin; Erik P Sulman; Krishna Bhat; J Matthew McDonald; W K Alfred Yung; Howard Colman; Shiao Y Woo; Amy B Heimberger; Dima Suki; Michael D Prados; Susan M Chang; Fred G Barker; Jan C Buckner; C David James; Kenneth Aldape
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2288-94.
2007: Diane Palmieri; Julie L Bronder; Jeanne M Herring; Toshiyuki Yoneda; Robert J Weil; Andreas M Stark; Raffael Kurek; Eleazar Vega-Valle; Lionel Feigenbaum; Douglas Halverson; Alexander O Vortmeyer; Seth M Steinberg; Kenneth Aldape; Patricia S Steeg
Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain.
Cancer research 2007;67(9):4190-8.
2007: Melissa V Olson; David G Johnson; Hong Jiang; Jing Xu; Marta M Alonso; Kenneth Aldape; Gregory N Fuller; B Nebiyou Bekele; W K Alfred Yung; Candelaria Gomez-Manzano; Juan Fueyo
Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors.
Cancer research 2007;67(9):4005-9.
2007: Sandeep Kunwar; Michael D Prados; Susan M Chang; Mitchel S Berger; Frederick F Lang; Joseph M Piepmeier; John H Sampson; Zvi Ram; Philip H Gutin; Robert D Gibbons; Kenneth Aldape; David Croteau; Jeffrey W Sherman; Raj K Puri
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(7):837-44.
2007: Liliana Soroceanu; Samir Kharbanda; Ruihuan Chen; Robert Soriano; Kenneth Aldape; Anjan Misra; Jiping Zha; William F Forrest; Janice M Nigro; Zora Modrusan; Burt Feuerstein; Heidi S Phillips
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3466-71.
2007: Kenneth Aldape; Peter C Burger; Arie Perry
Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma.
Archives of pathology & laboratory medicine 2007;131(2):242-51.
2007: Mukesh K Sharma; David B Mansur; Guido Reifenberger; Arie Perry; Jeffrey R Leonard; Kenneth Aldape; Meredith G Albin; Ryan J Emnett; Simon Loeser; Mark A Watson; Rakesh Nagarajan; David H Gutmann
Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin.
Cancer research 2007;67(3):890-900.
2007: Maja Puchades; Carol L Nilsson; Mark R Emmett; Kenneth Aldape; Yongjie Ji; Frederick F Lang; Ta-Jen Liu; Charles A Conrad
Proteomic investigation of glioblastoma cell lines treated with wild-type p53 and cytotoxic chemotherapy demonstrates an association between galectin-1 and p53 expression.
Journal of proteome research 2007;6(2):869-75.
2007: Arnab Chakravarti; Erin Tyndall; Kamalakannan Palanichamy; Minesh Mehta; Kenneth Aldape; Jay Loeffler
Impact of molecular profiling on clinical trial design for glioblastoma.
Current oncology reports 2007;9(1):71-9.
2006: Ok-Hee Lee; Jing Xu; Juan Fueyo; Gregory N Fuller; Kenneth Aldape; Marta M Alonso; Yuji Piao; Ta-Jen Liu; Frederick F Lang; B Nebiyou Bekele; Candelaria Gomez-Manzano
Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix.
Molecular cancer research : MCR 2006;4(12):915-26.
2006: Morris D Groves; Vinay K Puduvalli; Charles A Conrad; Mark R Gilbert; W K Alfred Yung; Kurt A Jaeckle; Vivien Liu; Kenneth R Hess; Kenneth Aldape; Victor Levin
Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status.
Journal of neuro-oncology 2006;80(1):83-90.
2006: Judith A Schwartzbaum; James Larry Fisher; Kenneth Aldape; Margaret Wrensch
Epidemiology and molecular pathology of glioma.
Nature clinical practice. Neurology 2006;2(9):494-503; quiz 1 p following 516.
2006: Patrick Y Wen; W K Alfred Yung; Kathleen R Lamborn; Patricia Dahia; Yanfeng Wang; Bin Peng; Lauren E Abrey; Jeffrey Raizer; Timothy F Cloughesy; Karen Fink; Mark Gilbert; Susan Chang; Larry Junck; David Schiff; Frank Lieberman; Howard A Fine; Minesh Mehta; H Ian Robins; Lisa De Angelis; Morris D Groves; Vinay K Puduvalli; Victor Levin; Charles Conrad; Elizabeth A Maher; Kenneth Aldape; Michael Hayes; Laurie Letvak; Merrill J Egorin; Renaud Capdeville; Richard S. Kaplan; Anthony J Murgo; Charles D Stiles; Michael D Prados
Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(16):4899-907.
2006: Arnab Chakravarti; Michael G Erkkinen; Ulf Nestler; Roger Stupp; Minesh Mehta; Kenneth Aldape; Mark R Gilbert; Peter Black; Jay S Loeffler
Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4738-46.
2006: Kelly N Blehm; Philippe E Spiess; Jolanta Bondaruk; Melanie E Dujka; Gabriel J Villares; Yi-Jue Zhao; Oliver Bogler; Kenneth Aldape; H Barton Grossman; Liana Adam; David J McConkey; Bogdan Czerniak; Colin P N Dinney; Menashe Bar-Eli
Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4671-7.
2006: Timothy F Cloughesy; Patrick Y Wen; H Ian Robins; Susan M Chang; Morris D Groves; Karen L Fink; Larry Junck; David Schiff; Lauren E Abrey; Mark R Gilbert; Frank S Lieberman; John Kuhn; Lisa De Angelis; Minesh Mehta; Jeffrey J Raizer; W K Alfred Yung; Kenneth Aldape; John Wright; Kathleen R Lamborn; Michael D Prados
Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(22):3651-6.
2006: Christopher E Pelloski; E Lin; LI Zhang; W K Alfred Yung; Howard Colman; Juinn-Lin Liu; Shiao Y Woo; Amy B Heimberger; Dima Suki; Michael Prados; Susan Chang; Fred G Barker; Gregory N Fuller; Kenneth Aldape
Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(13):3935-41.
2006: S Farzana Hussain; David Yang; Dima Suki; Kenneth Aldape; Elizabeth Grimm; Amy B Heimberger
The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses.
Neuro-oncology 2006;8(3):261-79.
2006: Ok-Hee Lee; Juan Fueyo; Jing Xu; W K Alfred Yung; Michael G Lemoine; Frederick F Lang; B Nebiyou Bekele; Xian Zhou; Marta A Alonso; Kenneth Aldape; Gregory N Fuller; Candelaria Gomez-Manzano
Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth.
Neoplasia (New York, N.Y.) 2006;8(5):419-28.
2006: Howard Colman; Caterina Giannini; Li Huang; Javier Gonzalez; Kenneth Hess; Janet Bruner; Gregory Fuller; Lauren Langford; Christopher E Pelloski; Joann Aaron; Peter C Burger; Kenneth Aldape
Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas.
The American journal of surgical pathology 2006;30(5):657-64.
2006: Rongcai Jiang; Cristian Mircean; Ilya Shmulevich; David Cogdell; Yu Jia; Ioan Tabus; Kenneth Aldape; Raymond Sawaya; Janet M Bruner; Gregory N Fuller; Wei Zhang
Pathway alterations during glioma progression revealed by reverse phase protein lysate arrays.
Proteomics 2006;6(10):2964-71.
2006: James L Rubenstein; Jane Fridlyand; Arthur Shen; Kenneth Aldape; David Ginzinger; Tracy Batchelor; Patrick Treseler; Mitchel Berger; Michael McDermott; Michael Prados; Jon Karch; Craig Y Okada; William Hyun; Seema Parikh; Christopher Haqq; Marc Shuman
Gene expression and angiotropism in primary CNS lymphoma.
Blood 2006;107(9):3716-23.
2006: Margaret Wrensch; John K Wiencke; Joseph L Wiemels; Rei Miike; Joe Patoka; Michelle Moghadassi; Alex McMillan; Karl T Kelsey; Kenneth Aldape; Kathleen R Lamborn; Andrew T Parsa; Jennette D Sison; Michael D Prados
Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival.
Cancer research 2006;66(8):4531-41.
2006: Mingguang Liu; Bingbing Dai; Shin-Hyuk Kang; Kechen Ban; Feng-Ju Huang; Frederick F Lang; Kenneth Aldape; Tong-xin Xie; Christopher E Pelloski; Keping Xie; Raymond Sawaya; Suyun Huang
FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells.
Cancer research 2006;66(7):3593-602.
2006: Luo Wang; Qingyi Wei; Li-E Wang; Kenneth Aldape; Yumei Cao; M Fatih Okcu; Kenneth R Hess; Randa A el-Zein; Mark R Gilbert; Shiao Y Woo; Sujit S Prabhu; Gregory N Fuller; Melissa L Bondy
Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(10):1627-32.
2006: Tong-xin Xie; Feng-Ju Huang; Kenneth Aldape; Shin-Hyuk Kang; Mingguang Liu; jeffrey gershenwald; Keping Xie; Raymond Sawaya; Suyun Huang
Activation of stat3 in human melanoma promotes brain metastasis.
Cancer research 2006;66(6):3188-96.
2006: Heidi S Phillips; Samir Kharbanda; Ruihuan Chen; William F Forrest; Robert Soriano; Thomas D Wu; Anjan Misra; Janice M Nigro; Latif Shooshtari Nasrin; Liliana Soroceanu; P Mickey Williams; Zora Modrusan; Burt Feuerstein; Kenneth Aldape
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.
Cancer cell 2006;9(3):157-73.
2006: Xiaohua Su; Vidya Gopalakrishnan; duncan stearns; Kenneth Aldape; Fredrick F Lang; Gregory Fuller; Evan Snyder; Charles G Eberhart; Sadhan Majumder
Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation.
Molecular and cellular biology 2006;26(5):1666-78.
2006: J Matthew McDonald; Sarah Dunlap; David Cogdell; Valerie Dunmire; Qingyi Wei; Anna Starzinski-Powitz; Raymond Sawaya; Janet Bruner; Gregory N Fuller; Kenneth Aldape; Wei Zhang
The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.
Cancer biology & therapy 2006;5(3):300-4.
2006: Mukesh K Sharma; Mark A Watson; M Lyman; Arie Perry; Kenneth Aldape; F Deák; David H Gutmann
Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma.
Neurology 2006;66(1):127-30.
2006: Yu Liang; Andrew W Bollen; Kenneth Aldape; Nalin Gupta
Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma.
BMC cancer 2006;6():97.
2006: Margaret Wrensch; Terri Rice; Rei Miike; Alex McMillan; Kathleen R Lamborn; Kenneth Aldape; Michael D Prados
Diagnostic, treatment, and demographic factors influencing survival in a population-based study of adult glioma patients in the San Francisco Bay Area.
Neuro-oncology 2006;8(1):12-26.
2005: Marta M Alonso; Juan Fueyo; Jerry W Shay; Kenneth Aldape; Hong Jiang; Ok-Hee Lee; David G Johnson; Jing Xu; Yasuko Kondo; Takao Kanzawa; Satoru Kyo; B Nebiyou Bekele; Xian Zhou; Janice Nigro; J Matthew McDonald; W K Alfred Yung; Candelaria Gomez-Manzano
Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance.
Journal of the National Cancer Institute 2005;97(21):1589-600.
2005: Margaret Wrensch; James Larry Fisher; Judith A Schwartzbaum; Melissa Bondy; Mitchel Berger; Kenneth Aldape
The molecular epidemiology of gliomas in adults.
Neurosurgical focus 2005;19(5):E5.
2005: Amy B Heimberger; Dima Suki; David Yang; Weiming Shi; Kenneth Aldape
The natural history of EGFR and EGFRvIII in glioblastoma patients.
Journal of translational medicine 2005;3():38.
2005: Carmen J Marsit; John K Wiencke; Heather H Nelson; Duk-Hwan Kim; Philip W Hinds; Kenneth Aldape; Karl T Kelsey
Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survival.
Cancer genetics and cytogenetics 2005;162(2):115-21.
2005: Margaret Wrensch; Karl T Kelsey; Mei Liu; Rei Miike; Michelle Moghadassi; Jennette D Sison; Kenneth Aldape; Alex McMillan; Joseph L Wiemels; John K Wiencke
ERCC1 and ERCC2 polymorphisms and adult glioma.
Neuro-oncology 2005;7(4):495-507.
2005: J Matthew McDonald; Siew-Ju See; Ivo W Tremont; Howard Colman; Mark R Gilbert; Morris Groves; Peter C Burger; David N Louis; Caterina Giannini; Gregory Fuller; Sandra Passe; Hilary Blair; Robert B Jenkins; Helen Yang; Alicia Ledoux; Joann Aaron; Ulka Tipnis; Wei Zhang; Kenneth Hess; Kenneth Aldape
The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors.
Cancer 2005;104(7):1468-77.
2005: Sean D McAllister; Calvin Chan; Ryan J Taft; Tri Luu; Mary E Abood; Dan H Moore; Kenneth Aldape; Garret Yount
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.
Journal of neuro-oncology 2005;74(1):31-40.
2005: Susan M Chang; Patrick Y Wen; Timothy F Cloughesy; Harry S Greenberg; David Schiff; Charles Conrad; Karen Fink; H Ian Robins; Lisa De Angelis; Jeffrey J Raizer; Kenneth Hess; Kenneth Aldape; Kathleen R Lamborn; John Kuhn; Janet Dancey; Michael D Prados
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme.
Investigational new drugs 2005;23(4):357-61.
2005: Carmen J Marsit; Shichun Zheng; Kenneth Aldape; Philip W Hinds; Heather H Nelson; John K Wiencke; Karl T Kelsey
PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration.
Human pathology 2005;36(7):768-76.
2005: John K Wiencke; Kenneth Aldape; Alex McMillan; Joseph L Wiemels; Michelle Moghadassi; Rei Miike; Karl T Kelsey; Joe Patoka; Jeff Long; Margaret Wrensch
Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(7):1774-83.
2005: Margaret Wrensch; Adriana Weinberg; John K Wiencke; Rei Miike; Jennette D Sison; Joseph L Wiemels; Geoffrey R Barger; Gerald DeLorenze; Kenneth Aldape; Karl Kelsey
History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls.
American journal of epidemiology 2005;161(10):929-38.
2005: Christopher E Pelloski; Anita Mahajan; Moshe H Maor; Eric L Chang; Shiao Woo; Mark Gilbert; Howard Colman; Helen Yang; Alicia Ledoux; Hilary Blair; Sandra Passe; Robert B Jenkins; Kenneth Aldape
YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3326-34.
2005: Yu Liang; Maximilian Diehn; Nathan Watson; Andrew W Bollen; Kenneth Aldape; M Kelly Nicholas; Kathleen R Lamborn; Mitchel S Berger; David Botstein; Patrick O Brown; Mark Israel
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5814-9.
2005: Janice M Nigro; Anjan Misra; LI Zhang; Ivan Smirnov; Howard Colman; Chandi Griffin; Natalie Ozburn; Mingang Chen; Edward Pan; Dimpy Koul; W K Alfred Yung; Burt Feuerstein; Kenneth Aldape
Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma.
Cancer research 2005;65(5):1678-86.
2005: Amy B Heimberger; Roman Hlatky; Dima Suki; David Yang; Jeff Weinberg; Mark Gilbert; Raymond Sawaya; Kenneth Aldape
Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(4):1462-6.
2005: Weida Gong; Liwei Wang; James C Yao; Jaffer A Ajani; Daoyan Wei; Kenneth Aldape; Keping Xie; Raymond Sawaya; Suyun Huang
Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(4):1386-93.
2005: J Matthew McDonald; Valerie Dunmire; Ellen Taylor; Raymond Sawaya; Janet Bruner; Gregory N Fuller; Kenneth Aldape; Wei Zhang
Attenuated expression of DFFB is a hallmark of oligodendrogliomas with 1p-allelic loss.
Molecular cancer 2005;4():35.
2004: Carmen J Marsit; Masayuki Hasegawa; Tomoko Hirao; Duk-Hwan Kim; Kenneth Aldape; Philip W Hinds; John K Wiencke; Heather H Nelson; Karl T Kelsey
Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancer.
Cancer research 2004;64(23):8702-7.
2004: Arie Perry; Kenneth Aldape; David H George; Peter C Burger
Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma.
Cancer 2004;101(10):2318-26.
2004: Sujit S Prabhu; Kenneth Aldape; Janet M Bruner; Jeffrey S Weinberg
Cowden disease with Lhermitte-Duclos disease: case report.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2004;31(4):542-9.
2004: Teresa Ribalta; Ian E McCutcheon; Kenneth Aldape; Janet M Bruner; Gregory N Fuller
The mitosis-specific antibody anti-phosphohistone-H3 (PHH3) facilitates rapid reliable grading of meningiomas according to WHO 2000 criteria.
The American journal of surgical pathology 2004;28(11):1532-6.
2004: Li-E Wang; Melissa L Bondy; Hongbing Shen; Randa A el-Zein; Kenneth Aldape; Yumei Cao; Vinay Pudavalli; Victor Levin; W K Alfred Yung; Qingyi Wei
Polymorphisms of DNA repair genes and risk of glioma.
Cancer research 2004;64(16):5560-3.
2004: Makiko Umezu-Goto; Janos L Tanyi; John Lahad; Shuying Liu; Shuangxing Yu; Ruth Lapushin; Yutaka Hasegawa; Yiling Lu; Rosanne Trost; Therese Bevers; Eric Jonasch; Kenneth Aldape; Jinsong Liu; Robyn D James; Colin G Ferguson; Yong Xu; Glenn D Prestwich; Gordon B Mills
Lysophosphatidic acid production and action: validated targets in cancer?
Journal of cellular biochemistry 2004;92(6):1115-40.
2004: Garret Yount; Yifang Qian; Dan Moore; Daniel Basila; Jeremy West; Kenneth Aldape; Nils D Arvold; Noga Shalev; Daphne A Haas-Kogan
Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro.
Journal of experimental therapeutics & oncology 2004;4(2):137-43.
2004: Kenneth Aldape; Karla V Ballman; Alfred F Furth; Jan C Buckner; Caterina Giannini; Peter C Burger; Bernd W Scheithauer; Robert B Jenkins; C David James
Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance.
Journal of neuropathology and experimental neurology 2004;63(7):700-7.
2004: Alexander D Borowsky; Robert Jay Munn; Jose J Galvez; Robert Cardiff; Jerrold M Ward; Herbert C Morse; Scott C Kogan; Kenneth Aldape; David N Louis; Marcus W Bosenberg
Mouse models of human cancers (part 3).
Comparative medicine 2004;54(3):258-70.
2004: Yumi Watanabe; Sei Kameoka; Vidya Gopalakrishnan; Kenneth Aldape; Zhizhong Z Pan; Frederick F Lang; Sadhan Majumder
Conversion of myoblasts to physiologically active neuronal phenotype.
Genes & development 2004;18(8):889-900.
2004: Robert J Bohinski; Ehud Mendel; Kenneth Aldape; Laurence D Rhines
Intramedullary and extramedullary solitary fibrous tumor of the cervical spine. Case report and review of the literature.
Journal of neurosurgery 2004;100(4 Suppl Spine):358-63.
2004: Garret Yount; Jerry Solfvin; Dan Moore; Marilyn Schlitz; Melissa Reading; Kenneth Aldape; Yifang Qian
In vitro test of external Qigong.
BMC complementary and alternative medicine 2004;4():5.
2004: Margaret Wrensch; Karl T Kelsey; Mei Liu; Rei Miike; Michelle Moghadassi; Kenneth Aldape; Alex McMillan; John K Wiencke
Glutathione-S-transferase variants and adult glioma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(3):461-7.
2004: Ajay Pandita; Kenneth Aldape; Gelareh Zadeh; Abhijit Guha; C David James
Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR.
Genes, chromosomes & cancer 2004;39(1):29-36.
2003: Corinna Trebst; Susan M Staugaitis; Barbara Tucky; Tao Wei; K Suzuki; Kenneth Aldape; CARLOS PARDO-VILLAMIZAR; Juan C Troncoso; Hans Lassmann; Richard M Ransohoff
Chemokine receptors on infiltrating leucocytes in inflammatory pathologies of the central nervous system (CNS).
Neuropathology and applied neurobiology 2003;29(6):584-95.
2003: Sujit S Prabhu; Kenneth Aldape; Robert Gagel; Robert S Benjamin; Jonathan Trent; Ian E McCutcheon
Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2003;30(4):378-83.
2003: Frederick F Lang; Janet M Bruner; Gregory N Fuller; Kenneth Aldape; Michael D Prados; Susan Chang; Mitchel S Berger; Michael W McDermott; Sandeep Kunwar; Larry Junck; William F Chandler; James Zwiebel; Richard S. Kaplan; W K Alfred Yung
Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(13):2508-18.
2003: Hoon K Lee; Eric L Chang; Gregory N Fuller; Kenneth Aldape; George J Atkinson; Lawrence B Levy; Ian E McCutcheon; Moshe H Maor
The prognostic value of neurologic function in astrocytic spinal cord glioma.
Neuro-oncology 2003;5(3):208-13.
2003: LI Zhang; Michael F Miles; Kenneth Aldape
A model of molecular interactions on short oligonucleotide microarrays.
Nature biotechnology 2003;21(7):818-21.
2003: Meic H Schmidt; Mitchel S Berger; Kathleen R Lamborn; Kenneth Aldape; Michael W McDermott; Michael D Prados; Susan M Chang
Repeated operations for infiltrative low-grade gliomas without intervening therapy.
Journal of neurosurgery 2003;98(6):1165-9.
2003: William A Weiss; Michael J Burns; Christopher S Hackett; Kenneth Aldape; John R Hill; Hiroko Kuriyama; Nagato Kuriyama; Nadezhda Milshteyn; Tim Roberts; Michael F Wendland; Ronald A DePinho; Mark Israel
Genetic determinants of malignancy in a mouse model for oligodendroglioma.
Cancer research 2003;63(7):1589-95.
2003: Yuichi Hirose; Kenneth Aldape; Susan Chang; Kathleen R Lamborn; Mitchel S Berger; Burt Feuerstein
Grade II astrocytomas are subgrouped by chromosome aberrations.
Cancer genetics and cytogenetics 2003;142(1):1-7.
2003: Kenneth Aldape; M Fatih Okcu; Melissa L Bondy; Margaret Wrensch
Molecular epidemiology of glioblastoma.
Cancer journal (Sudbury, Mass.) 2003;9(2):99-106.
2003: Corinna Trebst; Susan M Staugaitis; Pia Kivisäkk; Don J Mahad; Martha K Cathcart; Barbara Tucky; Tao Wei; Mysore R Sandhya Rani; Richard Horuk; Kenneth Aldape; CARLOS PARDO-VILLAMIZAR; Claudia F Lucchinetti; Hans Lassmann; Richard M Ransohoff
CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages.
The American journal of pathology 2003;162(2):427-38.
2003: James L Rubenstein; Dan Combs; Jay Rosenberg; Arthur Levy; Michael McDermott; Lloyd Damon; Robert Ignoffo; Kenneth Aldape; Arthur Shen; Dana Lee; Antonio Grillo-Lopez; Marc Shuman
Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment.
Blood 2003;101(2):466-8.
2002: Eric C Burton; Kathleen R Lamborn; Burt Feuerstein; Michael Prados; James Scott; Peter Forsyth; Sandra Passe; Robert B Jenkins; Kenneth Aldape
Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma.
Cancer research 2002;62(21):6205-10.
2002: William A Weiss; Mark Israel; Charles S Cobbs; Eric C Holland; C David James; David N Louis; Cheryl Marks; Andrea I McClatchey; Tim Roberts; Terry Van Dyke; Cynthia Wetmore; Ing-Ming Chiu; Marco Giovannini; Abhijit Guha; Robert J Higgins; Silvia Marino; Ivan Radovanovic; Karlyne M Reilly; Kenneth Aldape
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.
Oncogene 2002;21(49):7453-63.
2002: Cornelia S von Koch; Mittul Gulati; Kenneth Aldape; Mitchel S Berger
Familial medulloblastoma: case report of one family and review of the literature.
Neurosurgery 2002;51(1):227-33; discussion 233.
2002: James Rubenstein; Nancy J Fischbein; Kenneth Aldape; Eric Burton; Marc Shuman
Hemorrhage and VEGF expression in a case of primary CNS lymphoma.
Journal of neuro-oncology 2002;58(1):53-6.
2002: Christos D Katsetos; Luis Del Valle; Jennian F Geddes; Kenneth Aldape; James C Boyd; Agustin Legido; Kamel Khalili; Elias Perentes; Sverre J Mörk
Localization of the neuronal class III beta-tubulin in oligodendrogliomas: comparison with Ki-67 proliferative index and 1p/19q status.
Journal of neuropathology and experimental neurology 2002;61(4):307-20.
2002: Eric C Burton; Kathleen R Lamborn; Peter Forsyth; James Scott; Jason O'Campo; Jane Uyehara-Lock; Michael Prados; Mitchel Berger; Sandra Passe; Joon H Uhm; Brian P O'Neill; Robert B Jenkins; Kenneth Aldape
Aberrant p53, mdm2, and proliferation differ in glioblastomas from long-term compared with typical survivors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):180-7.
2002: Kenneth Aldape; David Ginzinger; Tony E Godfrey
Real-time quantitative polymerase chain reaction: a potential tool for genetic analysis in neuropathology.
Brain pathology (Zurich, Switzerland) 2002;12(1):54-66.
2001: Jeanne M Soos; Jeffrey I Krieger; Olaf Stüve; C L King; Juan C Patarroyo; Kenneth Aldape; Karolina Wosik; Anthony J Slavin; P A Nelson; Jack P Antel; Scott S Zamvil
Malignant glioma cells use MHC class II transactivator (CIITA) promoters III and IV to direct IFN-gamma-inducible CIITA expression and can function as nonprofessional antigen presenting cells in endocytic processing and CD4(+) T-cell activation.
Glia 2001;36(3):391-405.
2001: Peter C Burger; Dennis K Pearl; Kenneth Aldape; Allan J Yates; Bernd W Scheithauer; Sandra Passe; Robert B Jenkins; C D James
Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme?
Journal of neuropathology and experimental neurology 2001;60(11):1099-104.
2001: Fred G Barker; ML Simmons; Susan M Chang; Michael D Prados; David A Larson; Penny K Sneed; William M Wara; Mitchel S Berger; P Chen; Mark Israel; Kenneth Aldape
EGFR overexpression and radiation response in glioblastoma multiforme.
International journal of radiation oncology, biology, physics 2001;51(2):410-8.
2001: Yukihiko Sonoda; T Ozawa; Kenneth Aldape; Dennis F Deen; Mitchel S Berger; Russell O Pieper
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
Cancer research 2001;61(18):6674-8.
2001: Yukihiko Sonoda; T Ozawa; Yuichi Hirose; Kenneth Aldape; M McMahon; Mitchel S Berger; Russell O Pieper
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.
Cancer research 2001;61(13):4956-60.
2001: P Chen; Kenneth Aldape; John K Wiencke; Karl T Kelsey; Rei Miike; R L Davis; J Liu; A Kesler-Diaz; M Takahashi; Margaret Wrensch
Ethnicity delineates different genetic pathways in malignant glioma.
Cancer research 2001;61(10):3949-54.
2001: Y Hirose; Kenneth Aldape; M Takahashi; M S Berger; Burt Feuerstein
Tissue microdissection and degenerate oligonucleotide primed-polymerase chain reaction (DOP-PCR) is an effective method to analyze genetic aberrations in invasive tumors.
The Journal of molecular diagnostics : JMD 2001;3(2):62-7.
2001: Janice M Nigro; M A Takahashi; David Ginzinger; Mark Law; Sandra Passe; Robert B Jenkins; Kenneth Aldape
Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay.
The American journal of pathology 2001;158(4):1253-62.
2001: Y Hirose; Kenneth Aldape; Andrew Bollen; C D James; Daniel J Brat; Kathleen R Lamborn; M Berger; Burt Feuerstein
Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups.
The American journal of pathology 2001;158(3):1137-43.
2001: ML Simmons; Kathleen R Lamborn; M Takahashi; P Chen; Mark Israel; Mitchel S Berger; Tony E Godfrey; Janice M Nigro; Michael Prados; S Chang; F G Barker; Kenneth Aldape
Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients.
Cancer research 2001;61(3):1122-8.
2000: P Chen; John K Wiencke; Kenneth Aldape; A Kesler-Diaz; Rei Miike; Karl Kelsey; M Lee; Jihong Liu; Margaret Wrensch
Association of an ERCC1 polymorphism with adult-onset glioma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(8):843-7.
2000: Kenneth Aldape; ML Simmons; R L Davis; Rei Miike; John K Wiencke; Geoffrey R Barger; Marion M Lee; P Chen; Margaret Wrensch
Discrepancies in diagnoses of neuroepithelial neoplasms: the San Francisco Bay Area Adult Glioma Study.
Cancer 2000;88(10):2342-9.
2000: edward cooper; Kenneth Aldape; Aviva Abosch; Nicholas M Barbaro; Mitchel S Berger; W S Peacock; Yuh Nung Jan; Lily Yeh Jan
Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4914-9.
2000: Matthew D Smyth; Lawrence H Pitts; Robert K Jackler; Kenneth Aldape
Metastatic spinal ependymoma presenting as a vestibular schwannoma. Case illustration.
Journal of neurosurgery 2000;92(2 Suppl):247.
1998: Garret Yount; Daphne A Haas-Kogan; K S Levine; Kenneth Aldape; Mark Israel
Ionizing radiation inhibits chemotherapy-induced apoptosis in cultured glioma cells: implications for combined modality therapy.
Cancer research 1998;58(17):3819-25.
1998: Susanne Ostrowitzki; J Fick; Timothy P L Roberts; Michael F Wendland; Kenneth Aldape; Jeffry S Mann; Mark Israel; Robert C Brasch
Comparison of gadopentetate dimeglumine and albumin-(Gd-DTPA)30 for microvessel characterization in an intracranial glioma model.
Journal of magnetic resonance imaging : JMRI 1998;8(4):799-806.
1998: A Gualberto; Kenneth Aldape; Krystyna Kozakiewicz; Thea D Tlsty
An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5166-71.
1997: Janice M Nigro; Kenneth Aldape; S M Hess; Thea D Tlsty
Cellular adhesion regulates p53 protein levels in primary human keratinocytes.
Cancer research 1997;57(17):3635-9.
1997: William A Weiss; Kenneth Aldape; G Mohapatra; Burt Feuerstein; John M Bishop
Targeted expression of MYCN causes neuroblastoma in transgenic mice.
The EMBO journal 1997;16(11):2985-95.
1997: Fred G Barker; Ping Chen; F Furman; Kenneth Aldape; Michael S Edwards; Mark Israel
P16 deletion and mutation analysis in human brain tumors.
Journal of neuro-oncology 1997;31(1-2):17-23.
1996: Charles S Cobbs; D S Levi; Kenneth Aldape; Mark Israel
Manganese superoxide dismutase expression in human central nervous system tumors.
Cancer research 1996;56(14):3192-5.
1995: Jay E Brenman; D S Chao; H Xia; Kenneth Aldape; David S Bredt
Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy.
Cell 1995;82(5):743-52.
1995: J M Breuss; J Gallo; H M DeLisser; Irina Klimanskaya; Hans Folkesson; Jean-François Pittet; S L Nishimura; Kenneth Aldape; D V Landers; W Carpenter
Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling.
Journal of cell science 1995;108 ( Pt 6)():2241-51.
1995: Charles S Cobbs; Jay E Brenman; Kenneth Aldape; David S Bredt; Mark Israel
Expression of nitric oxide synthase in human central nervous system tumors.
Cancer research 1995;55(4):727-30.
1994: Kenneth Aldape; H Huizinga; J Bouvier; James H McKerrow
Naegleria fowleri: characterization of a secreted histolytic cysteine protease.
Experimental parasitology 1994;78(2):230-41.
1992: Brian G Herndier; Bruce Shiramizu; N E Jewett; Kenneth Aldape; G R Reyes; Michael S McGrath
Acquired immunodeficiency syndrome-associated T-cell lymphoma: evidence for human immunodeficiency virus type 1-associated T-cell transformation.
Blood 1992;79(7):1768-74.
1991: Fred Cohen; Lydia Gregoret; P Amiri; Kenneth Aldape; J Railey; James H McKerrow
Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling.
Biochemistry 1991;30(47):11221-9.
1991: Kenneth Aldape; H S Fox; J P Roberts; Nancy L Ascher; John R Lake; H A Rowley
Cladosporium trichoides cerebral phaeohyphomycosis in a liver transplant recipient. Report of a case.
American journal of clinical pathology 1991;95(4):499-502.
1985: A C Porter; C Kumamoto; Kenneth Aldape; Robert D Simoni
Role of the b subunit of the Escherichia coli proton-translocating ATPase. A mutagenic analysis.
The Journal of biological chemistry 1985;260(13):8182-7.