FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Christopher McGuigan

Research Profile

Chemicals & Drugs

Concepts & Ideas

Living Beings

Co-author Network

Publications

TOP 3
Nadege Hamon; Jan Balzarini; Maurizio Quintiliani; Christopher McGuigan
Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate.
Claire Bourdin; Andrea Brancale; K Dawn Bryant; Stanley Chamberlain; Babita Ganguly; Elena Gorovits; Geoffrey Henson; Damound Hunley; Jeff Hutchins; Alexander Kolykhalov; Christopher McGuigan; Jerry Muhammad; Aleksandr Obikhod; Joseph Patti; Changalvala V S Ramamurty; Srinivas K Battina; Blair Bleiman; John Vernachio; C Robin Walters; Jin Wang; C Srivinas Rao
Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
Silvia Meneghesso; Lieve Naesens; Evelien Vanderlinden; Jan Balzarini; Andrea Brancale; Christopher McGuigan
Synthesis and biological evaluation of purine 2'-fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Christopher McGuigan (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Nadege Hamon; Jan Balzarini; Maurizio Quintiliani; Christopher McGuigan
Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate.
Bioorganic & medicinal chemistry letters 2013;23(9):2555-9.
2013: Claire Bourdin; Andrea Brancale; K Dawn Bryant; Stanley Chamberlain; Babita Ganguly; Elena Gorovits; Geoffrey Henson; Damound Hunley; Jeff Hutchins; Alexander Kolykhalov; Christopher McGuigan; Jerry Muhammad; Aleksandr Obikhod; Joseph Patti; Changalvala V S Ramamurty; Srinivas K Battina; Blair Bleiman; John Vernachio; C Robin Walters; Jin Wang; C Srivinas Rao
Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
Bioorganic & medicinal chemistry letters 2013;23(7):2260-4.
2013: Silvia Meneghesso; Lieve Naesens; Evelien Vanderlinden; Jan Balzarini; Andrea Brancale; Christopher McGuigan
Synthesis and biological evaluation of purine 2'-fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents.
ChemMedChem 2013;8(3):415-25.
2013: Christopher McGuigan; Ranjith N Pathirana; Laura Farleigh; Karen Hinsinger; Joachim J Bugert
Novel antiviral activity of l-dideoxy bicyclic nucleoside analogues versus vaccinia and measles viruses in vitro.
Journal of medicinal chemistry 2013;56(3):1311-22.
2012: Michaela Serpi; Carlos Raul Alaez Verson; Stephanie Rat; Helen Roberts; María José Alcaraz; Rita Bibbo; Bruce Caterson; Anna Torrent Gibert; Claire Hughes; Christopher McGuigan
Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants.
Journal of medicinal chemistry 2012;55(10):4629-39.
2012: Johan Vande Voorde; Sandra Liekens; Christopher McGuigan; Maurizio Quintiliani; Jan Balzarini
Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative.
Biochemical pharmacology 2012;83(10):1358-63.
2012: Karolina Madela; Christopher McGuigan
Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.
Future medicinal chemistry 2012;4(5):625-50.
2012: Silvia Meneghesso; Jan Balzarini; Christopher McGuigan; Annelies Stevaert; Evelien Vanderlinden; Lieve Naesens
Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus.
Antiviral research 2012;94(1):35-43.
2012: Graciela Andrei; Jan Balzarini; Pierre Fiten; Christopher McGuigan; Ghislain Opdenakker; D Topalis; Robert Snoeck
In vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.
Journal of virology 2012;86(5):2641-52.
2012: Fabrizio Pertusati; Michaela Serpi; Christopher McGuigan
Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy.
Antiviral chemistry & chemotherapy 2012;22(5):181-203.
2011: Christopher McGuigan; Paola Murziani; Magdalena Slusarczyk; Johan Vande Voorde; Blanka Gonczy; Sandra Liekens; Jan Balzarini
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Journal of medicinal chemistry 2011;54(20):7247-58.
2011: Christopher McGuigan; Changalvala V S Ramamurty; C Srinivas Rao; John Vernachio; Arnaud Gilles; Andrea Hall; Geoffrey Henson; Jeff Hutchins; Alexander Kolykhalov; Karolina Madela; Mohamed Aljarah; Srinivas K Battina; Stanley Chamberlain
Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
Bioorganic & medicinal chemistry letters 2011;21(19):6007-12.
2011: Maurizio Quintiliani; Robert Snoeck; Nicola Solaroli; Leentje Persoons; Graciela Andrei; Jan Balzarini; Anna Karlsson; Christopher McGuigan
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Bioorganic & medicinal chemistry 2011;19(14):4338-45.
2011: Paul Trippier; Jan Balzarini; Christopher McGuigan
Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: bisphenylboronic acids.
Antiviral chemistry & chemotherapy 2011;21(3):129-42.
2010: Alwena H Morgan; Victoria J Hammond; Lloyd Morgan; Christopher P Thomas; Keri A Tallman; Yoel R Garcia-Diaz; Christopher McGuigan; Michaela Serpi; Ned A Porter; Robert C Murphy; Valerie B O'Donnell
Quantitative assays for esterified oxylipins generated by immune cells.
Nature protocols 2010;5(12):1919-31.
2010: Christopher McGuigan; Karolina Madela; Mohamed Aljarah; Arnaud Gilles; Andrea Brancale; Nicola Zonta; Stanley Chamberlain; John Vernachio; Jeff Hutchins; Andrea Hall; Brenda Ames; Elena Gorovits; Babita Ganguly; Alexander Kolykhalov; Jin Wang; Jerry Muhammad; Joseph M Patti; Geoffrey Henson
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
Bioorganic & medicinal chemistry letters 2010;20(16):4850-4.
2010: Christopher McGuigan; Arnaud Gilles; Karolina Madela; Mohamed Aljarah; Sabrina Holl; Sarah Jones; John Vernachio; Jeff Hutchins; Brenda Ames; K Dawn Bryant; Elena Gorovits; Babita Ganguly; Damound Hunley; Andrea Hall; Alexander Kolykhalov; Yule Liu; Jerry Muhammad; Nicholas Raja; Robin Walters; Jin Wang; Stanley Chamberlain; Geoffrey Henson
Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
Journal of medicinal chemistry 2010;53(13):4949-57.
2010: Youcef Mehellou; Rocco Valente; Huw Mottram; Elisabeth Walsby; Kenneth I Mills; Jan Balzarini; Christopher McGuigan
Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism.
Bioorganic & medicinal chemistry 2010;18(7):2439-46.
2010: Marco Derudas; Andrea Brancale; Lieve Naesens; Johan Neyts; Jan Balzarini; Christopher McGuigan
Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin.
Bioorganic & medicinal chemistry 2010;18(7):2748-55.
2010: Marco Derudas; Maurizio Quintiliani; Andrea Brancale; Graciela Andrei; Robert Snoeck; Jan Balzarini; Christopher McGuigan
Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue.
Antiviral chemistry & chemotherapy 2010;21(1):15-31.
2010: Jane Lane; Tracey A Martin; Christopher McGuigan; Malcolm D Mason; Wen G Jiang
The differential expression of hCNT1 and hENT1 i n breast cancer and the possible impact on breast cancer therapy.
Journal of experimental therapeutics & oncology 2010;8(3):203-10.
2010: Paul Trippier; Christopher McGuigan; Jan Balzarini
Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids.
Antiviral chemistry & chemotherapy 2010;20(6):249-57.
2010: Youcef Mehellou; Jan Balzarini; Christopher McGuigan
The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-beta-D-(arabinofuranosyl)uracil phosphoramidate ProTides.
Antiviral chemistry & chemotherapy 2010;20(4):153-60.
2009: Christopher McGuigan; Marco Derudas; Maurizio Quintiliani; Graciela Andrei; Robert Snoeck; Geoffrey Henson; Jan Balzarini
2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.
Bioorganic & medicinal chemistry letters 2009;19(22):6264-7.
2009: Youcef Mehellou; Jan Balzarini; Christopher McGuigan
Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells.
ChemMedChem 2009;4(11):1779-91.
2009: Christopher McGuigan; Jan Balzarini
FV100 as a new approach for the possible treatment of varicella-zoster virus infection.
The Journal of antimicrobial chemotherapy 2009;64(4):671-3.
2009: Marco Derudas; Davide Carta; Andrea Brancale; Christophe Vanpouille; Andrea Lisco; Leonid Margolis; Jan Balzarini; Christopher McGuigan
The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.
Journal of medicinal chemistry 2009;52(17):5520-30.
2009: Christopher McGuigan; Plinio Perrone; Karolina Madela; Johan Neyts
The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
Bioorganic & medicinal chemistry letters 2009;19(15):4316-20.
2009: Christopher McGuigan; Mary Rose Kelleher; Plinio Perrone; Sinead Mulready; Giovanna M Luoni; Felice Daverio; Sonal Rajyaguru; Sophie Le Pogam; Isabel Najera; Joseph A Martin; Klaus Klumpp; David B Smith
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
Bioorganic & medicinal chemistry letters 2009;19(15):4250-4.
2009: Youcef Mehellou; Jan Balzarini; Christopher McGuigan
An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.
Organic & biomolecular chemistry 2009;7(12):2548-53.
2009: Christopher McGuigan; Felice Daverio; Isabel Nájera; Joseph A Martin; Klaus Klumpp; David B Smith
The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
Bioorganic & medicinal chemistry letters 2009;19(11):3122-4.
2009: Christopher McGuigan; Olivier Bidet; Marco Derudas; Graciela Andrei; Robert Snoeck; Jan Balzarini
Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus.
Bioorganic & medicinal chemistry 2009;17(8):3025-7.
2008: Christopher McGuigan; Marco Derudas; Joachim Bugert; Graciela Andrei; Robert Snoeck; Jan Balzarini
Successful kinase bypass with new acyclovir phosphoramidate prodrugs.
Bioorganic & medicinal chemistry letters 2008;18(15):4364-7.
2007: Christopher McGuigan; Ranjith N Pathirana; Marco Migliore; Rina Adak; Giovanna M Luoni; Arwyn T Jones; Alberto Díez-Torrubia; Maria-Jose Camarasa; Sonsoles Velázquez; Geoffrey Henson; Erik Verbeken; Rebecca Sienaert; Lieve Naesens; Robert Snoeck; Graciela Andrei; Jan Balzarini
Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.
The Journal of antimicrobial chemotherapy 2007;60(6):1316-30.
2007: Plinio Perrone; Felice Daverio; Rocco Valente; Sonal Rajyaguru; Joseph A Martin; Vincent Lévêque; Sophie Le Pogam; Isabel Najera; Klaus Klumpp; David B Smith; Christopher McGuigan
First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
Journal of medicinal chemistry 2007;50(22):5463-70.
2007: Youcef Mehellou; Christopher McGuigan; Andrea Brancale; Jan Balzarini
Design, synthesis, and anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U), 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.
Bioorganic & medicinal chemistry letters 2007;17(13):3666-9.
2007: Plinio Perrone; Giovanna M Luoni; Mary Rose Kelleher; Felice Daverio; Annette Angell; Sinead Mulready; Costantino Congiatu; Sonal Rajyaguru; Joseph A Martin; Vincent Levêque; Sophie Le Pogam; Isabel Najera; Klaus Klumpp; David B Smith; Christopher McGuigan
Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
Journal of medicinal chemistry 2007;50(8):1840-9.
2007: Costantino Congiatu; Andrea Brancale; Christopher McGuigan
Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1121-4.
2006: Christopher McGuigan; Alshaimaa Hassan-Abdallah; Sheila Srinivasan; Yikang Wang; Adam Siddiqui; Susan M Daluge; Kristjan S Gudmundsson; Huiqiang Zhou; Ed W McLean; Jennifer P Peckham; Thimysta C Burnette; Harry Marr; Richard J Hazen; Lynn Condreay; Lance Johnson; Jan Balzarini
Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives.
Journal of medicinal chemistry 2006;49(24):7215-26.
2006: Christopher McGuigan; Jan Balzarini
Aryl furano pyrimidines: the most potent and selective anti-VZV agents reported to date.
Antiviral research 2006;71(2-3):149-53.
2006: Costantino Congiatu; Andrea Brancale; Malcolm D Mason; Wen Jiang; Christopher McGuigan
Novel potential anticancer naphthyl phosphoramidates of BVdU: separation of diastereoisomers and assignment of the absolute configuration of the phosphorus center.
Journal of medicinal chemistry 2006;49(2):452-5.
2006: Kasem Abdulmajed; Christopher McGuigan; Charles M Heard
Topical delivery of retinyl ascorbate co-drug. 5. In vitro degradation studies.
Skin pharmacology and physiology 2006;19(5):248-58.
2005: Kasem Abdulmajed; Christopher McGuigan; Charles M Heard
Topical delivery of retinyl ascorbate co-drug: 6. Determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes.
Die Pharmazie 2005;60(10):794-5.
2005: Charles M Heard; Simon J Gallagher; Costantino Congiatu; John Harwood; Christopher P Thomas; Christopher McGuigan; Marta Nemcová; Tereza Nouskova
Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation.
International journal of pharmaceutics 2005;302(1-2):47-55.
2005: Giovanna M Luoni; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain.
Bioorganic & medicinal chemistry letters 2005;15(16):3791-6.
2005: Christopher McGuigan; Sarah A Harris; Susan M Daluge; Kristjan S Gudmundsson; Ed W McLean; Thimysta C Burnette; Harry Marr; Richard J Hazen; Lynn Condreay; Lance Johnson; Erik De Clercq; Jan Balzarini
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Journal of medicinal chemistry 2005;48(10):3504-15.
2005: Christopher McGuigan; Jean-Christophe Thiery; Felice Daverio; Wen Jiang; Gaynor Davies; Malcolm Mason
Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin.
Bioorganic & medicinal chemistry 2005;13(9):3219-27.
2005: Kasem Abdulmajed; Christopher McGuigan; Charles M Heard
Topical delivery of retinyl ascorbate: 4. Comparative anti-oxidant activity towards DPPH.
Free radical research 2005;39(5):491-8.
2005: Graciela Andrei; Rebecca Sienaert; Christopher McGuigan; Erik De Clercq; Jan Balzarini; Robert Snoeck
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides.
Antimicrobial agents and chemotherapy 2005;49(3):1081-6.
2005: M R Kelleher; Christopher McGuigan; Olivier Bidet; Antonella Carangio; H Weldon; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):643-5.
2005: F Gavazza; Felice Daverio; Andrew T Chaytor; Tudor M Griffith; Christopher McGuigan
Phosphoramidate derivatives of 2',5'-dideoxyadenosine as potential inhibitors of the EDHF phenomenon.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):553-5.
2005: Costantino Congiatu; Christopher McGuigan; Wen Jiang; Gaynor Davies; Malcolm D Mason
Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: design, synthesis and biological evaluation.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):485-9.
2004: Giovanna M Luoni; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of varicella-zoster virus modified on the sugar moiety: 3' and 5' derivatives.
Antiviral chemistry & chemotherapy 2004;15(6):333-41.
2004: Olivier Bidet; Christopher McGuigan; Robert Snoeck; Graciela Andrei; Erik De Clercq; Jan Balzarini
Non-nucleoside structures retain full anti-HCMV potency of the dideoxy furanopyrimidine family.
Antiviral chemistry & chemotherapy 2004;15(6):329-32.
2004: Kasem Abdulmajed; Charles M Heard; Christopher McGuigan; W John Pugh
Topical delivery of retinyl ascorbate co-drug. 2. Comparative skin tissue and keratin binding studies.
Skin pharmacology and physiology 2004;17(6):274-82.
2004: Jan Balzarini; Stefano Aquaro; Alshaimaa Hassan-Abdallah; Susan M Daluge; Carlo Federico Perno; Christopher McGuigan
Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels.
FEBS letters 2004;573(1-3):38-44.
2004: Chris A Jarvis; Christopher McGuigan; Charles M Heard
In vitro delivery of novel, highly potent anti-varicella zoster virus nucleoside analogues to their target site in the skin.
Pharmaceutical research 2004;21(6):914-9.
2004: Annette Angell; Christopher McGuigan; Luis Garcia Sevillano; Robert Snoeck; Graciela Andrei; Erik De Clercq; Jan Balzarini
Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity.
Bioorganic & medicinal chemistry letters 2004;14(10):2397-9.
2004: Tudor M Griffith; Andrew T Chaytor; David H Edwards; Felice Daverio; Christopher McGuigan
Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine.
British journal of pharmacology 2004;142(1):27-30.
2004: Dario Siccardi; Mark Gumbleton; Yadollah Omidi; Christopher McGuigan
Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;22(1):25-31.
2004: Christopher McGuigan; Ranjith N Pathirana; Robert Snoeck; Graciela Andrei; Erik De Clercq; Jan Balzarini
Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism.
Journal of medicinal chemistry 2004;47(7):1847-51.
2004: Rebecca Sienaert; Graciela Andrei; Robert Snoeck; Erik De Clercq; Christopher McGuigan; Jan Balzarini
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.
Biochemical and biophysical research communications 2004;315(4):877-83.
2004: Kristjan S Gudmundsson; Zhicheng Wang; Susan M Daluge; Lance C Johnson; Richard J Hazen; Lynn Condreay; Christopher McGuigan
Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.
Nucleosides, nucleotides & nucleic acids 2004;23(12):1929-37.
2004: Christopher McGuigan; Antonella Carangio; Robert Snoeck; Graciela Andrei; Erik De Clercq; Jan Balzarini
Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):1-5.
2003: Christopher McGuigan; Andrea Brancale; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity.
Bioorganic & medicinal chemistry letters 2003;13(24):4511-3.
2003: Dario Siccardi; Lana E Kandalaft; Mark Gumbleton; Christopher McGuigan
Stereoselective and concentration-dependent polarized epithelial permeability of a series of phosphoramidate triester prodrugs of d4T: an in vitro study in Caco-2 and Madin-Darby canine kidney cell monolayers.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1112-9.
2003: Kristjan S Gudmundsson; Susan M Daluge; Lance C Johnson; Robert Jansen; Richard J Hazen; Lynn Condreay; Christopher McGuigan
Phosphoramidate protides of 2',3'-dideoxy-3'-fluoroadenosine and related nucleosides with potent activity against HIV and HBV.
Nucleosides, nucleotides & nucleic acids 2003;22(10):1953-61.
2003: Chris A Jarvis; Charles M Heard; Christopher McGuigan
Targeted dermal delivery of highly potent anti-varicella zoster virus nucleoside analogues from saturated solutions and ethanolic oil-in-water creams.
Journal of drug targeting 2003;11(7):433-41.
2003: Rebecca Sienaert; Lieve Naesens; Andrea Brancale; Antonella Carangio; Graciela Andrei; Robert Snoeck; André B P van Kuilenburg; Erik De Clercq; Christopher McGuigan; Jan Balzarini
Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):995-7.
2003: Antonella Carangio; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of varicella-zoster virus: synthesis and biological evaluation of 2',3'-dideoxy-3'-fluoro and 2'-deoxy-xylo derivatives.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):935-7.
2003: Giovanna M Luoni; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):931-3.
2003: Olivier Bidet; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Synthesis of unusual bicyclic nucleosides bearing an unsaturated side-chain, as potential inhibitors of varicella-zoster virus (VZV).
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):817-9.
2003: Christopher McGuigan; Alison Jukes; Sally Blewett; Hubert Barucki; Jonathan T Erichsen; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Halophenyl furanopyrimidines as potent and selective anti-VZV agents.
Antiviral chemistry & chemotherapy 2003;14(3):165-70.
2002: Antonella Carangio; Sheila Srinivasan; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of varicella-zoster virus: effect of terminal aryl substitution in the side-chain.
Antiviral chemistry & chemotherapy 2002;13(5):263-71.
2002: Jan Balzarini; Christopher McGuigan
Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides.
Biochimica et biophysica acta 2002;1587(2-3):287-95.
2002: Jan Balzarini; Rebecca Sienaert; Sandra Liekens; André B P van Kuilenburg; Antonella Carangio; Robert M Esnouf; Erik De Clercq; Christopher McGuigan
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Molecular pharmacology 2002;61(5):1140-5.
2002: Christopher McGuigan; Sally Blewett; Dario Siccardi; Jonathan T Erichsen; Graciela Andrei; Robert Snoek; Erik De Clercq; Jan Balzarini
Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility.
Antiviral chemistry & chemotherapy 2002;13(2):91-9.
2002: Rebecca Sienaert; Lieve Naesens; Andrea Brancale; Erik De Clercq; Christopher McGuigan; Jan Balzarini
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.
Molecular pharmacology 2002;61(2):249-54.
2001: Andrea Brancale; Christopher McGuigan; B Algain; Pascal Savy; Rachid Benhida; Jean-Louis Fourrey; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity.
Bioorganic & medicinal chemistry letters 2001;11(18):2507-10.
2001: Sarah A Harris; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Antiviral chemistry & chemotherapy 2001;12(5):293-300.
2001: Antonella Carangio; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Pd-catalysed synthesis of 5-aryl derivatives and their biological evaluation.
Antiviral chemistry & chemotherapy 2001;12(3):187-97.
2001: C Ballatore; Christopher McGuigan; Erik De Clercq; Jan Balzarini
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
Bioorganic & medicinal chemistry letters 2001;11(8):1053-6.
2001: Sheila Srinivasan; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): effect of terminal unsaturation in the side-chain.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):763-6.
2001: Antonella Carangio; Christopher McGuigan; D Cahard; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Synthesis and in vitro evaluation of novel anti-varicella-zoster virus (VZV) nucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):653-6.
2001: Christopher McGuigan; Hubert Barucki; Antonella Carangio; Sally Blewett; Sheila Srinivasan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):287-96.
2001: Sally Blewett; Christopher McGuigan; Hubert Barucki; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1063-6.
2001: Christopher McGuigan; Andrea Brancale; Hubert Barucki; Sheila Srinivasan; G Jones; Ranjith N Pathirana; Antonella Carangio; Sally Blewett; G Luoni; Olivier Bidet; A Jukes; C Jarvis; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Furano pyrimidines as novel potent and selective anti-VZV agents.
Antiviral chemistry & chemotherapy 2001;12(2):77-89.
2001: Sheila Srinivasan; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain.
Bioorganic & medicinal chemistry letters 2001;11(3):391-3.
2000: Christopher McGuigan; Hubert Barucki; Antonella Carangio; Sally Blewett; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini; Jonathan T Erichsen
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
Journal of medicinal chemistry 2000;43(26):4993-7.
2000: Andrea Brancale; Sheila Srinivasan; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility.
Antiviral chemistry & chemotherapy 2000;11(6):383-93.
2000: Michael Knaggs; Christopher McGuigan; Sarah A Harris; P Heshmati; D Cahard; Ian H Gilbert; Jan Balzarini
A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T.
Bioorganic & medicinal chemistry letters 2000;10(18):2075-8.
2000: Christopher McGuigan; Ranjith N Pathirana; G Jones; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency.
Antiviral chemistry & chemotherapy 2000;11(5):343-8.
2000: Andrea Brancale; Christopher McGuigan; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.
Bioorganic & medicinal chemistry letters 2000;10(11):1215-7.
2000: Christopher McGuigan; Martin J Slater; Nigel R Parry; A Perry; S Harris
Synthesis and antiviral activity of acyclovir-5'-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug.
Bioorganic & medicinal chemistry letters 2000;10(7):645-7.
2000: Christopher McGuigan; L Bidois; A Hiouni; C Ballatore; Erik De Clercq; Jan Balzarini
Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine.
Antiviral chemistry & chemotherapy 2000;11(2):111-6.
2000: Adam Siddiqui; Christopher McGuigan; C Ballatore; Sheila Srinivasan; Erik De Clercq; Jan Balzarini
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs.
Bioorganic & medicinal chemistry letters 2000;10(4):381-4.
2000: Stefano Aquaro; O Wedgwood; CJ Yarnold; D Cahard; R Pathinara; Christopher McGuigan; R Calio'; Erik De Clercq; Jan Balzarini; Carlo Federico Perno
Activities of masked 2',3'-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophages.
Antimicrobial agents and chemotherapy 2000;44(1):173-7.
1999: Christopher McGuigan; CJ Yarnold; G Jones; Sonsoles Velázquez; Hubert Barucki; Andrea Brancale; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
Journal of medicinal chemistry 1999;42(22):4479-84.
1999: AQ Siddiqui; Christopher McGuigan; C Ballatore; Fabio Zuccotto; Ian H Gilbert; Erik De Clercq; Jan Balzarini
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.
Journal of medicinal chemistry 1999;42(20):4122-8.
1999: D Saboulard; Lieve Naesens; D Cahard; A Salgado; Ranjith N Pathirana; S Velazquez; Christopher McGuigan; Erik De Clercq; Jan Balzarini
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.
Molecular pharmacology 1999;56(4):693-704.
1999: AQ Siddiqui; Christopher McGuigan; C Ballatore; O Wedgwood; Erik De Clercq; Jan Balzarini
Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.
Bioorganic & medicinal chemistry letters 1999;9(17):2555-60.
1999: C Ballatore; Christopher McGuigan; Erik De Clercq; Jan Balzarini
An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs.
Nucleosides & nucleotides 1999;18(4-5):967-9.
1999: AQ Siddiqui; C Ballatore; Christopher McGuigan; Erik De Clercq; Jan Balzarini
The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.
Journal of medicinal chemistry 1999;42(3):393-9.
1998: Christopher McGuigan; D Cahard; C Ballatore; Adam Siddiqui; Erik De Clercq; Jan Balzarini
Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.
Bioorganic & medicinal chemistry letters 1998;8(21):2949-54.
1998: Christopher McGuigan; P W Sutton; D Cahard; K Turner; G O'Leary; Y Wang; Mark Gumbleton; Erik De Clercq; Jan Balzarini
Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).
Antiviral chemistry & chemotherapy 1998;9(6):473-9.
1998: Christopher McGuigan; A Perry; CJ Yarnold; P W Sutton; D Lowe; W Miller; S G Rahim; M J Slater
Synthesis and evaluation of some masked phosphate esters of the anti-herpesvirus drug 882C (netivudine) as potential antiviral agents.
Antiviral chemistry & chemotherapy 1998;9(3):233-43.
1998: Jan Balzarini; D Cahard; O Wedgwood; A Salgado; Sonsoles Velázquez; CJ Yarnold; Erik De Clercq; Christopher McGuigan; Halldor Thormar
Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;17(4):296-302.
1998: Christopher McGuigan; H W Tsang; P W Sutton; Erik De Clercq; Jan Balzarini
Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency.
Antiviral chemistry & chemotherapy 1998;9(2):109-15.
1998: Lieve Naesens; D Cahard; A Salgado; L Bidois; Erik De Clercq; Christopher McGuigan; Jan Balzarini
Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety.
Advances in experimental medicine and biology 1998;431():753-7.
1997: Christopher McGuigan; H W Tsang; D Cahard; K Turner; S Velazquez; A Salgado; L Bidois; Lieve Naesens; Erik De Clercq; Jan Balzarini
Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.
Antiviral research 1997;35(3):195-204.
1997: Jan Balzarini; J Kruining; O Wedgwood; Christophe Pannecouque; Stefano Aquaro; Carlo Federico Perno; Lieve Naesens; Myriam Witvrouw; Rudolf Heijtink; Erik De Clercq; Christopher McGuigan
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
FEBS letters 1997;410(2-3):324-8.
1996: Jan Balzarini; H Egberink; K Hartmann; D Cahard; T Vahlenkamp; H Thormar; E De Clercq; Christopher McGuigan
Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324.
Molecular pharmacology 1996;50(5):1207-13.
1996: Jan Balzarini; O Wedgwood; J Kruining; H Pelemans; R Heijtink; E De Clercq; Christopher McGuigan
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.
Biochemical and biophysical research communications 1996;225(2):363-9.
1996: Jan Balzarini; Anna Karlsson; Stefano Aquaro; Carlo Federico Perno; D Cahard; Lieve Naesens; E De Clercq; Christopher McGuigan
Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7295-9.
1996: Christopher McGuigan; D Cahard; H M Sheeka; E De Clercq; Jan Balzarini
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
Journal of medicinal chemistry 1996;39(8):1748-53.
1995: Christopher McGuigan; Y Wang; P A Riley
Synthesis and biological evaluation of substituted phosphate triester alkyl lyso phospholipids (ALPs) as novel potential anti-neoplastic agents.
FEBS letters 1995;372(2-3):259-63.
1995: G S Attard; Christopher McGuigan; A Mackenzie
Phase behaviour of novel phospholipid analogues.
Chemistry and physics of lipids 1995;76(1):41-8.
1994: Christopher McGuigan; Y Wang; P A Riley
Synthesis and biological evaluation of phosphate triester alkyl lysophospholipids (ALPs) as novel potential anti-neoplastic agents.
Anti-cancer drug design 1994;9(6):539-48.
1994: Christopher McGuigan; P Bellevergue; H Sheeka; N Mahmood; A J Hay
Certain phosphoramidate derivatives of dideoxy uridine (ddU) are active against HIV and successfully by-pass thymidine kinase.
FEBS letters 1994;351(1):11-4.
1994: Christopher McGuigan; M Davies; R Pathirana; N Mahmood; A J Hay
Synthesis and anti-HIV activity of some novel diaryl phosphate derivatives of AZT.
Antiviral research 1994;24(1):69-77.
1993: Christopher McGuigan; D Kinchington; M F Wang; S R Nicholls; C Nickson; S Galpin; D J Jeffries; T J O'Connor
Nucleoside analogues previously found to be inactive against HIV may be activated by simple chemical phosphorylation.
FEBS letters 1993;322(3):249-52.
1993: Christopher McGuigan; R N Pathirana; Jan Balzarini; E De Clercq
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
Journal of medicinal chemistry 1993;36(8):1048-52.
1992: Christopher McGuigan; C Nickson; J Petrik; A Karpas
Phosphate derivatives of AZT display enhanced selectivity of action against HIV 1 by comparison to the parent nucleoside.
FEBS letters 1992;310(2):171-4.
1992: Christopher McGuigan; R N Pathirana; N Mahmood; K G Devine; A J Hay
Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT.
Antiviral research 1992;17(4):311-21.
1992: Christopher McGuigan; C Nickson; T J O'Connor; D Kinchington
Synthesis and anti-HIV activity of some novel lactyl and glycolyl phosphate derivatives.
Antiviral research 1992;17(3):197-212.
1991: Christopher McGuigan; T J O'Connor; B Swords; D Kinchington
Simple phospholipids have selective anti-HIV activity.
AIDS (London, England) 1991;5(12):1536-7.
1991: Christopher McGuigan; K G Devine; T J O'Connor; D Kinchington
Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound.
Antiviral research 1991;15(3):255-63.
1990: D Curley; Christopher McGuigan; K G Devine; T J O'Connor; D J Jeffries; D Kinchington
Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity.
Antiviral research 1990;14(6):345-56.
1990: K G Devine; Christopher McGuigan; T J O'Connor; S R Nicholls; D Kinchington
Novel phosphate derivatives of zidovudine as anti-HIV compounds.
AIDS (London, England) 1990;4(4):371-3.
1989: Christopher McGuigan; J M Shackleton; S M Tollerfield; Patrick A Riley
Synthesis and evaluation of some novel phosphate and phosphinate derivatives of araA. Studies on the mechanism of action of phosphate triesters.
Nucleic acids research 1989;17(24):10171-7.
1989: B C Jones; Christopher McGuigan; Patrick A Riley
Synthesis and biological evaluation of some phosphate triester derivatives of the anti-cancer drug araC.
Nucleic acids research 1989;17(18):7195-201.
1989: Christopher McGuigan; S M Tollerfield; Patrick A Riley
Synthesis and biological evaluation of some phosphate triester derivatives of the anti-viral drug AraA.
Nucleic acids research 1989;17(15):6065-75.