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Ward Kirlin

Research Profile

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Acetylation

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TOP 3
R Y Odom; M Y Dansby; A M Rollins-Hairston; K M Jackson; Ward G Kirlin
Phytochemical induction of cell cycle arrest by glutathione oxidation and reversal by N-acetylcysteine in human colon carcinoma cells.
Jiyang Cai; Ward G Kirlin; Yan Chen; Xuexian Yan; Dean P Jones; Alan C Sartorelli
Overexpression of heat shock factor 1 inhibits butyrate-induced differentiation in colon cancer cells.
Dean P Jones; Young-Mi Go; Corinna L Anderson; Thomas R Ziegler; Joseph M Kinkade; Ward G Kirlin
Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control.

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2009: R Y Odom; M Y Dansby; A M Rollins-Hairston; K M Jackson; Ward G Kirlin
Phytochemical induction of cell cycle arrest by glutathione oxidation and reversal by N-acetylcysteine in human colon carcinoma cells.
Nutrition and cancer 2009;61(3):332-9.
2006: Jiyang Cai; Ward G Kirlin; Yan Chen; Xuexian Yan; Dean P Jones; Alan C Sartorelli
Overexpression of heat shock factor 1 inhibits butyrate-induced differentiation in colon cancer cells.
Cell stress & chaperones 2006;11(3):199-207.
2004: Dean P Jones; Young-Mi Go; Corinna L Anderson; Thomas R Ziegler; Joseph M Kinkade; Ward G Kirlin
Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(11):1246-8.
2002: J W Rodriguez; Michael J Kohan; Leon C King; Ward G Kirlin
Detection of DNA adducts in developing CD4+ CD8+ thymocytes and splenocytes following in utero exposure to benzo[a]pyrene.
Immunopharmacology and immunotoxicology 2002;24(3):365-81.
2002: Lauren T Miller; WALTER WATSON; Ward G Kirlin; Thomas R Ziegler; Dean P Jones
Oxidation of the glutathione/glutathione disulfide redox state is induced by cysteine deficiency in human colon carcinoma HT29 cells.
The Journal of nutrition 2002;132(8):2303-6.
1999: Ward G Kirlin; Jiyang Cai; S A Thompson; D Diaz; T J Kavanagh; Dean P Jones
Glutathione redox potential in response to differentiation and enzyme inducers.
Free radical biology & medicine 1999;27(11-12):1208-18.
1999: Ward G Kirlin; Jiyang Cai; Mary J DeLong; EJ Patten; Dean P Jones
Dietary compounds that induce cancer preventive phase 2 enzymes activate apoptosis at comparable doses in HT29 colon carcinoma cells.
The Journal of nutrition 1999;129(10):1827-35.
1999: J W Rodriguez; Ward G Kirlin; Y G Wirsiy; S Matheravidathu; Thomas Hodge; P Urso
Maternal exposure to benzo[a]pyrene alters development of T lymphocytes in offspring.
Immunopharmacology and immunotoxicology 1999;21(2):379-96.
1996: M Lee; Ward G Kirlin; M Sturrup; J Rodriguez; P Urso
Variation in the response of T cells to concanavalin A after in vitro exposure to benzo[A]pyrene and 2-aminofluorene.
Immunopharmacology and immunotoxicology 1996;18(2):309-21.
1993: J W Rodriguez; Ward G Kirlin; R J Ferguson; Mark A Doll; K Gray; TD Rustan; M E Lee; K Kemp; P Urso; David W Hein
Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.
Archives of toxicology 1993;67(7):445-52.
1992: T J Flammang; Toks Yerokun; Matthew Bryant; Letha H Couch; Ward G Kirlin; K J Lee; F Ogolla; R J Ferguson; G Talaska; David W Hein
Hemoglobin adduct and hepatic- and urinary bladder-DNA adduct levels in rapid and slow acetylator Syrian inbred hamsters administered 2-aminofluorene.
The Journal of pharmacology and experimental therapeutics 1992;260(2):865-71.
1991: Ward G Kirlin; F Ogolla; A F Andrews; A Trinidad; R J Ferguson; Toks Yerokun; M Mpezo; David W Hein
Acetylator genotype-dependent expression of arylamine N-acetyltransferase in human colon cytosol from non-cancer and colorectal cancer patients.
Cancer research 1991;51(2):549-55.
1990: A Trinidad; David W Hein; TD Rustan; R J Ferguson; L S Miller; K D Bucher; Ward G Kirlin; F Ogolla; A F Andrews
Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.
Cancer research 1990;50(24):7942-9.
1990: F Ogolla; R J Ferguson; Ward G Kirlin; A Trinidad; A F Andrews; M Mpezo; David W Hein
Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):680-5.
1990: Toks Yerokun; David W Hein; R J Ferguson; F Ogolla; R H Heflich; T Y Minor; A Trinidad; Ward G Kirlin; A F Andrews
Relationship of Syrian inbred hamster acetylator genotype to the mutagenic activation of 2-aminofluorene.
Mutagenesis 1990;5(3):233-9.
1990: David W Hein; A Trinidad; Toks Yerokun; Ward G Kirlin; F Ogolla; R J Ferguson; A F Andrews
Genetic regulation of acetyltransferases in the Syrian inbred hamster: a model for man.
Progress in clinical and biological research 1990;340B():115-24.
1989: Ward G Kirlin; A Trinidad; Toks Yerokun; F Ogolla; R J Ferguson; A F Andrews; P K Brady; David W Hein
Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol.
Cancer research 1989;49(9):2448-54.
1989: A Trinidad; Ward G Kirlin; F Ogolla; A F Andrews; Toks Yerokun; R J Ferguson; P K Brady; David W Hein
Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):238-47.
1989: Toks Yerokun; Ward G Kirlin; A Trinidad; R J Ferguson; F Ogolla; A F Andrews; P K Brady; David W Hein
Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):231-7.
1988: David W Hein; A Trinidad; Toks Yerokun; R J Ferguson; Ward G Kirlin; Wendell W Weber
Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):341-7.
1987: David W Hein; T J Flammang; Ward G Kirlin; A Trinidad; F Ogolla
Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase.
Carcinogenesis 1987;8(12):1767-74.
1987: David W Hein; Ward G Kirlin; Toks Yerokun; A Trinidad; F Ogolla
Inheritance of acetylator genotype-dependent arylamine N-acetyltransferase in hamster bladder cytosol.
Carcinogenesis 1987;8(5):647-52.
1987: David W Hein; Ward G Kirlin; F Ogolla; A Trinidad
Extrahepatic expression of N-acetylator genotype in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(1):68-73.
1986: David W Hein; Ward G Kirlin; R J Ferguson; L K Thompson; F Ogolla
Identification and inheritance of inbred hamster N-acetyltransferase isozymes in peripheral blood.
The Journal of pharmacology and experimental therapeutics 1986;239(3):823-8.
1986: David W Hein; Ward G Kirlin; F Ogolla; A Trinidad; L K Thompson; R J Ferguson
The role of acetylator genotype on hepatic and extrahepatic acetylation, deacetylation, and sulfation of 2-aminofluorene, 2-acetylaminofluorene, and N-hydroxy-2-acetylaminofluorene in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(5):566-73.
1985: David W Hein; Ward G Kirlin; R J Ferguson; Wendell W Weber
Biochemical investigation of the basis for the genetic N-acetylation polymorphism in the inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;234(2):358-64.
1985: David W Hein; Ward G Kirlin; R J Ferguson; Wendell W Weber
Inheritance of liver N-acetyltransferase activity in the rapid and slow acetylator inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;233(3):584-7.
1981: S B Kandasamy; Ward G Kirlin; P N Kaul
Prostacyclin-induced hypothermia: involvement of central histamine H2-receptors.
Life sciences 1981;28(22):2553-60.