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Mark Magnuson

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Yoshifumi Sato; Tomohiro Sawa; Kazuhito Tomizawa; Fan-Yan Wei; Takaaki Akaike; Frank J Gonzalez; Mitsutoki Hatta; Md Fazlul Karim; Mark Magnuson; Shoki Sato; Tatsuya Yoshizawa; Kazuya Yamagata
Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
Signe Horn; Jonas Ahnfelt-Rønne; Moritz Gegg; Mette C Jørgensen; Ryoichiro Kageyama; Mark Kalisz; Tino Klein; Sune Kobberup; Young-Yun Kong; Heiko Lickert; Jill Lindner; Mark Magnuson; Palle Serup; Jan N Jensen
Mind bomb 1 is required for pancreatic β-cell formation.
Leah A Potter; Christopher V E Wright; Eunyoung Choi; Susan Hipkens; Mark Magnuson
A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1.

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All Publications

2012: Yoshifumi Sato; Tomohiro Sawa; Kazuhito Tomizawa; Fan-Yan Wei; Takaaki Akaike; Frank J Gonzalez; Mitsutoki Hatta; Md Fazlul Karim; Mark Magnuson; Shoki Sato; Tatsuya Yoshizawa; Kazuya Yamagata
Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
The Journal of biological chemistry 2012;287(27):23236-45.
2012: Signe Horn; Jonas Ahnfelt-Rønne; Moritz Gegg; Mette C Jørgensen; Ryoichiro Kageyama; Mark Kalisz; Tino Klein; Sune Kobberup; Young-Yun Kong; Heiko Lickert; Jill Lindner; Mark Magnuson; Palle Serup; Jan N Jensen
Mind bomb 1 is required for pancreatic β-cell formation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7356-61.
2012: Leah A Potter; Christopher V E Wright; Eunyoung Choi; Susan Hipkens; Mark Magnuson
A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1.
Genesis (New York, N.Y. : 2000) 2012;50(4):384-92.
2012: Dorthe R Petersen; Carsten Gustavsen; Søren R Lindskog; Mark Magnuson; Kenneth S Zaret; Palle Serup
Engineering artificial signaling centers to polarize embryoid body differentiation.
Stem cells and development 2012;21(4):647-53.
2012: Daniel Kopinke; Christopher V E Wright; Marisa Brailsford; Fong Cheng Pan; Mark Magnuson; L Charles Murtaugh
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.
Developmental biology 2012;362(1):57-64.
2011: Jennifer L Plank; Audrey Y Frist; Alison W LeGrone; Mark Magnuson; Patricia A Labosky
Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy.
Endocrinology 2011;152(12):4589-600.
2011: James B Papizan; Ruth A Singer; Shuen-Ing Tschen; Anil Bhushan; Sangeeta Dhawan; Jessica M Friel; Susan B Hipkens; Mark Magnuson; Lori Sussel
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.
Genes & development 2011;25(21):2291-305.
2011: Hiroshi Watanabe; Tao Yang; Dina Myers Stroud; Naohito Tanabe; Dao W Wang; Thomas C Atack; Nagesh Chopra; Alfred L George; Lynn Hall; Louise Harris; Susan B Hipkens; Björn C Knollmann; Sabina Kupershmidt; Brenda Leake; John S Lowe; Mark Magnuson; Dan Mark Roden
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.
Circulation 2011;124(9):1001-11.
2011: Seth J Salpeter; A M James Shapiro; Noa Weinberg-Corem; Amir Eden; Benjamin Glaser; Zvi Granot; Joseph Grimsby; Agnes Klochendler; Mark Magnuson; Shay Porat; Yuval Dor
Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels.
Endocrinology 2011;152(7):2589-98.
2011: Sara X Chen; Rama Gangula; Susan Hipkens; Anna B Osipovich; David W Piston; Leah A Potter; Alessandro Ustione; Weiping Yuan; Mark Magnuson
Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice.
Disease models & mechanisms 2011;4(4):537-47.
2011: Thomas C Atack; Lynn Hall; Susan B Hipkens; Brenda Leake; John S Lowe; Mark Magnuson; Hiroshi Watanabe; Ping Yang; Tao Yang; Dina Myers Stroud; Dan Mark Roden
Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel.
Circulation research 2011;109(1):38-46.
2011: Shay Porat; Noa Weinberg-Corem; Sharona Tornovsky-Babaey; Rachel Schyr-Ben-Haroush; Ayat Hija; Miri Stolovich-Rain; Daniela Dadon; Zvi Granot; Vered Ben-Hur; Peter White; Christophe A Girard; Rotem Karni; Klaus kaestner; Frances M Ashcroft; Mark Magnuson; Ann Saada (Reisch); Joseph Grimsby; Benjamin Glaser; Yuval Dor
Control of pancreatic β cell regeneration by glucose metabolism.
Cell metabolism 2011;13(4):440-9.
2011: Yanyun Gu; Jill Lindner; Anil Kumar; Weiping Yuan; Mark Magnuson
Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
Diabetes 2011;60(3):827-37.
2010: Isabella Artner; Yan Hang; Magdalena Mazur; Tsunehiko Yamamoto; Min Guo; Jill Lindner; Mark Magnuson; Roland Stein
MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.
Diabetes 2010;59(10):2530-9.
2010: Toshihiko Masui; Galvin H Swift; Tye Deering; Chengcheng Shen; ward s coats; Qiaoming Long; Hans-Peter Elsässer; Mark Magnuson; Raymond J MacDonald
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
Gastroenterology 2010;139(1):270-80.
2010: Keunwook Lee; Prathyusha Gudapati; Srdjan Dragovic; Charles Spencer; Sebastian JOYCE; Nigel Killeen; Mark Magnuson; Mark Boothby
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.
Immunity 2010;32(6):743-53.
2010: Delphine Boulbes; Chien-Hung Chen; Tattym Shaikenov; Nitin K Agarwal; Timothy R Peterson; Terri A Addona; Hasmik Keshishian; Steven A Carr; Mark Magnuson; David M Sabatini; Dos D Sarbassov
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.
Molecular cancer research : MCR 2010;8(6):896-906.
2010: Anil Kumar; John C Lawrence; Dae Young Jung; Hwi Jin Ko; Susanna R Keller; Jason K Kim; Mark Magnuson; Thurl E Harris
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.
Diabetes 2010;59(6):1397-406.
2010: M Jiang; S Fernandez; W G Jerome; Y He; X Yu; H Cai; B Boone; Y Yi; Mark Magnuson; P Roy-Burman; R J Matusik; S B Shappell; S W Hayward
Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy.
Cell death and differentiation 2010;17(3):469-81.
2010: Caroline Treins; P H Warne; Mark Magnuson; Mario Pende; J Downward
Rictor is a novel target of p70 S6 kinase-1.
Oncogene 2010;29(7):1003-16.
2010: Michael A Siuta; Sabrina D Robertson; Heidi Kocalis; Christine Saunders; Paul J Gresch; Vivek Khatri; Chiyo Shiota; J Philip Kennedy; Craig W Lindsley; Lynette Daws; Daniel B Polley; Jeremy Veenstra-VanderWeele; Gregg D Stanwood; Mark Magnuson; Kevin D Niswender; Aurelio Galli
Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice.
PLoS biology 2010;8(6):e1000393.
2009: Hongjie Zhang; Elizabeth Tweedie Ables; Christine F Pope; M Kay Washington; Susan Hipkens; Anna L Means; Gunter Path; Jochen Seufert; Robert H Costa; Andrew B Leiter; Mark Magnuson; Maureen Gannon
Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.
Mechanisms of development 2009;126(11-12):958-73.
2009: Eric D Berglund; Robert S Lee-Young; Daniel G Lustig; Sara E Lynes; E Patrick Donahue; Raul C Camacho; M Elizabeth Meredith; Mark Magnuson; Maureen J Charron; David H Wasserman
Hepatic energy state is regulated by glucagon receptor signaling in mice.
The Journal of clinical investigation 2009;119(8):2412-22.
2009: Sui Wang; Jan N Jensen; Philip A Seymour; Wei Hsu; Yuval Dor; Maike Sander; Mark Magnuson; Palle Serup; Guoqiang Gu
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9715-20.
2009: David A Guertin; Deanna M Stevens; Maki Saitoh; Stephanie Kinkel; Katherine Crosby; Joon-Ho Sheen; David J Mullholland; Mark Magnuson; Hong Wu; David M Sabatini
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
Cancer cell 2009;15(2):148-59.
2009: Stacey S Huppert; Mark Magnuson
New complexity in differentiating stem cells toward hepatic and pancreatic fates.
Science signaling 2009;2(83):pe50.
2008: Thomas P Flagg; Harley T Kurata; Ricard Masia; George Caputa; Mark Magnuson; David J Lefer; William A Coetzee; Colin G Nichols
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.
Circulation research 2008;103(12):1458-65.
2008: Bogumil Zelent; Stella Odili; Carol Buettger; Chiyo Shiota; Joseph Grimsby; Rebecca Taub; Mark Magnuson; Jane M Vanderkooi; Franz M Matschinsky
Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence.
The Biochemical journal 2008;413(2):269-80.
2008: G Nana Hagan; Yenshou Lin; Mark Magnuson; Joseph Avruch; Michael P Czech
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Molecular and cellular biology 2008;28(13):4215-26.
2008: Jared S Burlison; Qiaoming Long; Yoshio Fujitani; Christopher V E Wright; Mark Magnuson
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.
Developmental biology 2008;316(1):74-86.
2008: John Elrod; Maddison Harrell; Thomas P Flagg; Susheel Gundewar; Mark Magnuson; Colin G Nichols; William A Coetzee; David J Lefer
Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.
Circulation 2008;117(11):1405-13.
2008: Masakazu Shiota; Mark Magnuson
Hepatic glucose sensing: does flux matter?
The Journal of clinical investigation 2008;118(3):841-4.
2008: Maureen Gannon; Elizabeth Tweedie Ables; Laura Crawford; David Lowe; Martin F Offield; Mark Magnuson; Christopher V E Wright
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.
Developmental biology 2008;314(2):406-17.
2008: Kei Hori; Justyna Cholewa-Waclaw; Yuji Nakada; Stacey M Glasgow; Toshihiko Masui; R Michael Henke; Hendrik Wildner; Benedetta Martarelli; Thomas M Beres; Jonathan A Epstein; Mark Magnuson; Raymond J MacDonald; Carmen Birchmeier; Jane E Johnson
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Genes & development 2008;22(2):166-78.
2008: Anil Kumar; Thurl E Harris; Susanna R Keller; Kin M Choi; Mark Magnuson; John C Lawrence
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.
Molecular and cellular biology 2008;28(1):61-70.
2007: Sui Wang; Jia Zhang; Aizhen Zhao; Susan Hipkens; Mark Magnuson; Guoqiang Gu
Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
Mechanisms of development 2007;124(11-12):898-910.
2007: Mark Magnuson; Jared Burlison
Caveats and considerations for performing pancreas-specific gene manipulations in the mouse.
Diabetes, obesity & metabolism 2007;9 Suppl 2():5-13.
2007: Toshihiko Masui; Qiaoming Long; Thomas M Beres; Mark Magnuson; Raymond J MacDonald
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Genes & development 2007;21(20):2629-43.
2007: Kevin D Niswender; Mark Magnuson
Obesity and the beta cell: lessons from leptin.
The Journal of clinical investigation 2007;117(10):2753-6.
2007: Laura R Pearce; Xu Huang; Jérôme Boudeau; Rafał Pawłowski; Stephan Wullschleger; Maria Deak; Adel F M Ibrahim; Robert Gourlay; Mark Magnuson; Dario R Alessi
Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
The Biochemical journal 2007;405(3):513-22.
2007: Kazuya Yoshida; Koji Murao; Hitomi Imachi; Wen M Cao; Xiao Yu; Junhua Li; Rania A M Ahmed; Noriko Kitanaka; Norman C W Wong; Terry G Unterman; Mark Magnuson; Toshihiko Ishida
Pancreatic glucokinase is activated by insulin-like growth factor-I.
Endocrinology 2007;148(6):2904-13.
2007: Maria F Pino; Kyoung-Ah Kim; Kathy D Shelton; Jill Lindner; Stella Odili; Changhong Li; Heather W Collins; Masakazu Shiota; Franz M Matschinsky; Mark Magnuson
Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.
The Journal of biological chemistry 2007;282(18):13906-16.
2007: Shawn C Burgess; TianTeng He; Zheng Yan; Jill Lindner; A Dean Sherry; Craig R Malloy; Jeffrey D Browning; Mark Magnuson
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.
Cell metabolism 2007;5(4):313-20.
2006: Kai Liu; Susan Hipkens; Tao Yang; Robert Abraham; Wei Zhang; Nagesh Chopra; Björn C Knollmann; Mark Magnuson; Dan Mark Roden
Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.
Genesis (New York, N.Y. : 2000) 2006;44(11):556-64.
2006: Yoshio Fujitani; Shuko Fujitani; Huijun Luo; Feng Qiu; Jared Burlison; Qiaoming Long; Yoshiya Kawaguchi; Ulla Edlund; Raymond J MacDonald; Takahisa Furukawa; Takashi Fujikado; Mark Magnuson; Mengqing Xiang; Christopher V E Wright
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.
Development (Cambridge, England) 2006;133(22):4439-50.
2006: Chiyo Shiota; Jeong-taek Woo; Jill Lindner; Kathy D Shelton; Mark Magnuson
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.
Developmental cell 2006;11(4):583-9.
2006: Nicolai M Doliba; Wei Qin; Marko Z Vatamaniuk; Carol Buettger; Heather W Collins; Mark Magnuson; Klaus kaestner; David F Wilson; Richard D Carr; Franz M Matschinsky
Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E525-35.
2006: Bangyan Stiles; Christine Kuralwalla-Martinez; Wei Guo; Caroline Gregorian; Ying Wang; Jide Tian; Mark Magnuson; Hong Wu
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Molecular and cellular biology 2006;26(7):2772-81.
2006: Atsuko Miura; Kazuya Yamagata; Masafumi Kakei; Hiroyasu Hatakeyama; Noriko Takahashi; Kenji Fukui; Takao Nammo; Kazue Yoneda; Yusuke Inoue; Frances M Sladek; Mark Magnuson; Haruo Kasai; Jun-ichiro Miyagawa; Frank J Gonzalez; Iichiro Shimomura
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
The Journal of biological chemistry 2006;281(8):5246-57.
2006: Ji-Yeon Lee; Michael Ristow; Xueying Lin; Morris F White; Mark Magnuson; Lothar Hennighausen
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function.
The Journal of biological chemistry 2006;281(5):2649-53.
2006: Yoshio Fujitani; Shuko Fujitani; Daniel F Boyer; Maureen Gannon; Yoshiya Kawaguchi; Michael Ray; Masakazu Shiota; Roland W Stein; Mark Magnuson; Christopher V E Wright
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.
Genes & development 2006;20(2):253-66.
2006: Franz M Matschinsky; Mark Magnuson; Dorothy Zelent; Thomas L Jetton; Nicolai M Doliba; Yi Han; Rebecca Taub; Joseph Grimsby
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.
Diabetes 2006;55(1):1-12.
2005: René Thierbach; Tim J Schulz; Frank Isken; Anja Voigt; Brun Mietzner; Gunnar Drewes; Jürgen-Christoph von Kleist-Retzow; Rudolf J Wiesner; Mark Magnuson; Hélène Puccio; Andreas F H Pfeiffer; Pablo Steinberg; Michael Ristow
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
Human molecular genetics 2005;14(24):3857-64.
2005: Soo-Young Park; Xiaoyu Wang; Zhongyi Chen; Alvin C Powers; Mark Magnuson; W Steven Head; David W Piston; Graeme I Bell
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.
Genesis (New York, N.Y. : 2000) 2005;43(2):80-6.
2005: Chiyo Shiota; Jonathan V Rocheleau; Masakazu Shiota; David W Piston; Mark Magnuson
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor.
American journal of physiology. Endocrinology and metabolism 2005;289(4):E570-7.
2005: Youfei Guan; Chuanming Hao; Dae Ryong Cha; Reena Rao; Wendell Lu; Donald E Kohan; Mark Magnuson; Reyadh Redha; Yahua Zhang; Matthew D Breyer
Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption.
Nature medicine 2005;11(8):861-6.
2005: Vladimir R Babaev; Patricia G Yancey; Sergey V Ryzhov; Valentina Kon; Matthew D Breyer; Mark Magnuson; Sergio Fazio; MacRae F Linton
Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1647-53.
2005: Jennifer Roccisana; Vasumathi Reddy; Rupangi C Vasavada; Jose A Gonzalez-Pertusa; Mark Magnuson; Adolfo Garcia-Ocaña
Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass.
Diabetes 2005;54(7):2090-102.
2005: Chang-Zheng Wang; Yong Wang; Anke Di; Mark Magnuson; Honggang Ye; Michael W Roe; Deborah J Nelson; Graeme I Bell; Louis H Philipson
5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
Biochemical and biophysical research communications 2005;330(4):1073-9.
2005: Susan E Schonhoff; Laurie Baggio; Christelle Ratineau; Subir K Ray; Jill Lindner; Mark Magnuson; Daniel J Drucker; Andrew B Leiter
Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY.
Molecular and cellular biology 2005;25(10):4189-99.
2005: Julie R Jones; Cordelia Barrick; Kyoung-Ah Kim; Jill Lindner; bertrand blondeau; Yuka Fujimoto; Masakazu Shiota; Robert A Kesterson; Barbara B Kahn; Mark Magnuson
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6207-12.
2005: Anna L Gloyn; Stella Odili; Dorothy Zelent; Carol Buettger; Harriet A J Castleden; Anna M Steele; Amanda Stride; Chiyo Shiota; Mark Magnuson; Renata Lorini; Giuseppe d'Annunzio; Charles A Stanley; Jae Kwagh; Emile Van Schaftingen; Maria Veiga-da-Cunha; Fabrizio Barbetti; Pete Dunten; Yi Han; Joseph Grimsby; Rebecca Taub; Sian Ellard; Andrew T Hattersley; Franz M Matschinsky
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
The Journal of biological chemistry 2005;280(14):14105-13.
2005: Subhadra C Gunawardana; Manami Hara; Graeme I Bell; W Steven Head; Mark Magnuson; David W Piston
Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells.
In vitro cellular & developmental biology. Animal 2005;41(1-2):7-11.
2005: Julie R Jones; Kathy D Shelton; Mark Magnuson
Strategies for the use of site-specific recombinases in genome engineering.
Methods in molecular medicine 2005;103():245-57.
2004: Shawn C Burgess; Natasha Hausler; Matthew E Merritt; F Mark H Jeffrey; Charles Storey; Angela Milde; Seena Koshy; Jill Lindner; Mark Magnuson; Craig R Malloy; A Dean Sherry
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.
The Journal of biological chemistry 2004;279(47):48941-9.
2004: JM Moates; Mark Magnuson
The Pal elements in the upstream glucokinase promoter exhibit dyad symmetry and display cell-specific enhancer activity when multimerised.
Diabetologia 2004;47(9):1632-40.
2004: André Schneider; Youfei Guan; Yahua Zhang; Mark Magnuson; Cathy Pettepher; Charles D Loftin; Robert Langenbach; Richard M Breyer; Matthew D Breyer
Generation of a conditional allele of the mouse prostaglandin EP4 receptor.
Genesis (New York, N.Y. : 2000) 2004;40(1):7-14.
2004: Qiaoming Long; Kathy D Shelton; Jill Lindner; Julie R Jones; Mark Magnuson
Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection.
Genesis (New York, N.Y. : 2000) 2004;39(4):256-62.
2004: Shin-Ichi Gorogawa; Yoshio Fujitani; Hideaki Kaneto; Yoji Hazama; Hirotaka Watada; Yasuhide Miyamoto; Kiyoshi Takeda; Shizuo Akira; Mark Magnuson; Yoshimitsu Yamasaki; Yoshitaka Kajimoto; Masatsugu Hori
Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.
Biochemical and biophysical research communications 2004;319(4):1159-70.
2004: Renaud Dentin; Jean-Paul Pégorier; Fadila Benhamed; Fabienne Foufelle; Pascal Ferré; Véronique Fauveau; Mark Magnuson; JEAN R GIRARD; Catherine Postic
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.
The Journal of biological chemistry 2004;279(19):20314-26.
2004: Nicolai M Doliba; Wei Qin; Marko Z Vatamaniuk; Changhong Li; Dorothy Zelent; Habiba Najafi; Carol Buettger; Heather W Collins; Richard D Carr; Mark Magnuson; Franz M Matschinsky
Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
American journal of physiology. Endocrinology and metabolism 2004;286(5):E834-43.
2004: Christine A Biondi; Michael Gartside; Paul Waring; Kelly A Loffler; Mitchell S Stark; Mark Magnuson; Graham F Kay; Nicholas K Hayward
Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues.
Molecular and cellular biology 2004;24(8):3125-31.
2004: Chang An Chu; Yuka Fujimoto; Kayano Igawa; Joseph Grimsby; Joseph F Grippo; Mark Magnuson; Alan D Cherrington; Masakazu Shiota
Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(4):G627-34.
2004: Bangyan Stiles; Ying Wang; Andreas Stahl; Sara Bassilian; W Paul Lee; Yoon-Jung Kim; Robert S Sherwin; Sherin U Devaskar; Ralf Lesche; Mark Magnuson; Hong Wu
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected].
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2082-7.
2003: Takeshi Miyatsuka; Hideaki Kaneto; Yoshitaka Kajimoto; Shun Hirota; Y Arakawa; Yoshio Fujitani; Yutaka Umayahara; Hirotaka Watada; Yoshimitsu Yamasaki; Mark Magnuson; J i Miyazaki; Masatsugu Hori
Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.
Biochemical and biophysical research communications 2003;310(3):1017-25.
2003: Evan D Rosen; Rohit N Kulkarni; pasha sarraf; Umut Ozcan; Terumasa Okada; Chung-Hsin Hsu; Daniel Eisenman; Mark Magnuson; Frank J Gonzalez; C Ronald Kahn; Bruce M Spiegelman
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Molecular and cellular biology 2003;23(20):7222-9.
2003: Anna L Gloyn; Kees Noordam; Michèl A A P Willemsen; Sian Ellard; Wayne W K Lam; Ian W Campbell; Paula Midgley; Chiyo Shiota; Carol Buettger; Mark Magnuson; Franz M Matschinsky; Andrew T Hattersley
Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
Diabetes 2003;52(9):2433-40.
2003: Judy S Crabtree; Peter C Scacheri; Jerrold M Ward; Sara R McNally; Gary P Swain; Cristina Montagna; Jeffrey H Hager; Douglas Hanahan; Ulla Edlund; Mark Magnuson; Lisa Garrett-Beal; A Lee Burns; Thomas Ried; Settara C Chandrasekharappa; Stephen J Marx; Allen Spiegel; Francis S Collins
Of mice and MEN1: Insulinomas in a conditional mouse knockout.
Molecular and cellular biology 2003;23(17):6075-85.
2003: Mark Magnuson; Pengxiang She; Masakazu Shiota
Gene-altered mice and metabolic flux control.
The Journal of biological chemistry 2003;278(35):32485-8.
2003: Javier Martín; Sarah L Hunt; Pierre Dubus; Rocío Sotillo; Fanny Néhmé-Pélluard; Mark Magnuson; Albert F Parlow; Marcos Malumbres; Sagrario Ortega; Mariano Barbacid
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
Oncogene 2003;22(34):5261-9.
2003: Michael Ristow; Hindrik Mulder; Doreen Pomplun; Tim J Schulz; Katrin Müller-Schmehl; Anja Krause; Malin Fex; Hélène Puccio; Jörg Müller; Frank Isken; Joachim Spranger; Dirk Müller-Wieland; Mark Magnuson; Matthias Möhlig; Michel Koenig; Andreas F H Pfeiffer
Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.
The Journal of clinical investigation 2003;112(4):527-34.
2003: Verena Schulla; Erik Renström; Robert Feil; Susanne Feil; Isobel Franklin; Asllan Gjinovci; Xing-Jun Jing; Dirk Laux; Ingmar Lundquist; Mark Magnuson; Stefanie Obermüller; Charlotta S Olofsson; Albert Salehi; Anna Wendt; Norbert Klugbauer; Claes B Wollheim; Patrik Rorsman; Franz Hofmann
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.
The EMBO journal 2003;22(15):3844-54.
2003: Joseph Grimsby; Ramakanth Sarabu; Wendy L Corbett; Nancy-Ellen Haynes; Fred T Bizzarro; John W Coffey; Kevin R Guertin; Darryl W Hilliard; Robert F Kester; Paige E Mahaney; Linda Marcus; Lida Qi; Cheryl L Spence; John Tengi; Mark Magnuson; Chang An Chu; Mark T Dvorozniak; Franz M Matschinsky; Joseph F Grippo
Allosteric activators of glucokinase: potential role in diabetes therapy.
Science (New York, N.Y.) 2003;301(5631):370-3.
2003: Pengxiang She; Shawn C Burgess; Masakazu Shiota; Paul J Flakoll; E Patrick Donahue; Craig R Malloy; A Dean Sherry; Mark Magnuson
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
Diabetes 2003;52(7):1649-54.
2003: Colin Henderson; Diana M E Otto; Dianne Carrie; Mark Magnuson; Aileen W McLaren; Ian Rosewell; C Roland Wolf
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
The Journal of biological chemistry 2003;278(15):13480-6.
2003: Ying-Hue Lee; Mark Magnuson; Vijayakumar Muppala; Shih-Shun Chen
Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model.
Molecular and cellular biology 2003;23(3):923-32.
2003: Manami Hara; Xiaoyu Wang; Toshihiko Kawamura; Vytautas P Bindokas; Restituto F Dizon; Sergio Y Alcoser; Mark Magnuson; Graeme I Bell
Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.
American journal of physiology. Endocrinology and metabolism 2003;284(1):E177-83.
2002: Chiyo Shiota; Olof Larsson; Kathy D Shelton; Masakazu Shiota; Alexander M Efanov; Marianne Hoy; Jill Lindner; Suwattanee Kooptiwut; Lisa Juntti-Berggren; Jesper Gromada; Per-Olof Berggren; Mark Magnuson
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.
The Journal of biological chemistry 2002;277(40):37176-83.
2002: Mark A Rizzo; Mark Magnuson; Peter F Drain; David W Piston
A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin.
The Journal of biological chemistry 2002;277(37):34168-75.
2002: Rohit N Kulkarni; Martin Holzenberger; D Q Shih; Umut Ozcan; M Stoffel; Mark Magnuson; C Ronald Kahn
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
Nature genetics 2002;31(1):111-5.
2002: Henrik Christesen; Bendt Brock Jacobsen; Stella Odili; Carol Buettger; Antonio Cuesta Muñoz; Torben Hansen; Klaus Brusgaard; Ornella Massa; Mark Magnuson; Chiyo Shiota; Franz M Matschinsky; Fabrizio Barbetti
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
Diabetes 2002;51(4):1240-6.
2002: Hong-Bo Xin; Takaaki Senbonmatsu; Dong-sheng Cheng; Yong-Xiao Wang; Julio A Copello; Guang-Ju Ji; Mei Lin Collier; Ke-Yu Deng; Loice H Jeyakumar; Mark Magnuson; Tadashi Inagami; Michael I Kotlikoff; Sidney Fleischer
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
Nature 2002;416(6878):334-8.
2002: Julie R Jones; Kathy D Shelton; Youfei Guan; Matthew D Breyer; Mark Magnuson
Generation and functional confirmation of a conditional null PPARgamma allele in mice.
Genesis (New York, N.Y. : 2000) 2002;32(2):134-7.
2002: Anna Chytil; Mark Magnuson; Christopher V E Wright; Harold L Moses
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox.
Genesis (New York, N.Y. : 2000) 2002;32(2):73-5.
2001: Newman J Sund; Marko Z Vatamaniuk; M Casey; S L Ang; Mark Magnuson; Doris A Stoffers; Franz M Matschinsky; Klaus kaestner
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.
Genes & development 2001;15(13):1706-15.
2001: Alexander M Efanov; Marianne Høy; Robert Bränström; Sergei V Zaitsev; Mark Magnuson; Suad Efendic; Jesper Gromada; Per-Olof Berggren
The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function.
Biochemical and biophysical research communications 2001;284(4):918-22.
2001: Pål R Njølstad; Oddmund Søvik; A Cuesta-Muñoz; Lise Bjørkhaug; Ornella Massa; Fabrizio Barbetti; DAG UNDLIEN; Chiyo Shiota; Mark Magnuson; Anders Molven; Franz M Matschinsky; Graeme I Bell
Neonatal diabetes mellitus due to complete glucokinase deficiency.
The New England journal of medicine 2001;344(21):1588-92.
2001: Vijaykumar R Holla; F Adas; J D Imig; Xueying _ Zhao; Edward Price; Nancy Olsen; William Kovacs; Mark Magnuson; Diane S Keeney; Matthew D Breyer; John R Falck; Michael R Waterman; Jorge H Capdevila
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5211-6.
2001: Masakazu Shiota; C Postic; Yuka Fujimoto; Thomas L Jetton; K Dixon; D Pan; Joseph Grimsby; Joseph F Grippo; Mark Magnuson; Alan D Cherrington
Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.
Diabetes 2001;50(3):622-9.
2001: T Sakai; K J Johnson; Michihiro Murozono; K Sakai; Mark Magnuson; Tadeusz Wieloch; Tobias Cronberg; Atsushi Isshiki; H P Erickson; Reinhard Fässler
Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.
Nature medicine 2001;7(3):324-30.
2001: Thomas L Jetton; Masakazu Shiota; Susan M Knobel; David W Piston; Alan D Cherrington; Mark Magnuson
Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition.
International journal of experimental diabetes research 2001;2(3):173-86.
2001: C Postic; Masakazu Shiota; Mark Magnuson
Cell-specific roles of glucokinase in glucose homeostasis.
Recent progress in hormone research 2001;56():195-217.
2000: Jose P Silva; M Köhler; Caroline Graff; Anders Oldfors; Mark Magnuson; Per-Olof Berggren; Nils-Göran Larsson
Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
Nature genetics 2000;26(3):336-40.
2000: Pengxiang She; Masakazu Shiota; Kathy D Shelton; Roger Chalkley; C Postic; Mark Magnuson
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism.
Molecular and cellular biology 2000;20(17):6508-17.
2000: M Dodson Michael; Rohit N Kulkarni; C Postic; Stephen Previs; Gerald I Shulman; Mark Magnuson; C Ronald Kahn
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Molecular cell 2000;6(1):87-97.
2000: Newman J Sund; S L Ang; Sara D Sackett; W Shen; N Daigle; Mark Magnuson; Klaus kaestner
Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte.
Molecular and cellular biology 2000;20(14):5175-83.
2000: Yu-Jui Yvonne Wan; D An; Yan Cai; J J Repa; T Hung-Po Chen; M Flores; C Postic; Mark Magnuson; J Chen; K R Chien; S French; D J Mangelsdorf; H M Sucov
Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
Molecular and cellular biology 2000;20(12):4436-44.
2000: Joseph Grimsby; John W Coffey; M T Dvorozniak; J Magram; G Li; Franz M Matschinsky; Chiyo Shiota; S Kaur; Mark Magnuson; Joseph F Grippo
Characterization of glucokinase regulatory protein-deficient mice.
The Journal of biological chemistry 2000;275(11):7826-31.
2000: C Postic; Mark Magnuson
DNA excision in liver by an albumin-Cre transgene occurs progressively with age.
Genesis (New York, N.Y. : 2000) 2000;26(2):149-50.
1999: Chiyo Shiota; John W Coffey; Joseph Grimsby; Joseph F Grippo; Mark Magnuson
Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.
The Journal of biological chemistry 1999;274(52):37125-30.
1999: E A Davis; A Cuesta-Muñoz; M Raoul; Carol Buettger; IR Sweet; M Moates; Mark Magnuson; Franz M Matschinsky
Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.
Diabetologia 1999;42(10):1175-86.
1999: J T Lu; YJ Son; J Lee; Thomas L Jetton; Masakazu Shiota; LM Moscoso; Kevin D Niswender; A D Loewy; Mark Magnuson; Joshua R Sanes; Ronald B Emeson
Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development.
Molecular and cellular neurosciences 1999;14(2):99-120.
1999: Christine P Williams; C Postic; D Robin; P Robin; J Parrinello; Kathy D Shelton; Richard L Printz; Mark Magnuson; Daryl K Granner; Claude Forest; Roger Chalkley
Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites.
Molecular and cellular endocrinology 1999;148(1-2):67-77.
1999: Rohit N Kulkarni; Jens C Brüning; Jonathon Winnay; C Postic; Mark Magnuson; C Ronald Kahn
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
Cell 1999;96(3):329-39.
1999: Sabina Kupershmidt; Tao Yang; Mark E Anderson; A Wessels; Kevin D Niswender; Mark Magnuson; Dan Mark Roden
Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.
Circulation research 1999;84(2):146-52.
1999: C R Kennedy; Yahua Zhang; Suzanne Brandon; Youfei Guan; Keith Coffee; Colin D Funk; Mark Magnuson; John A Oates; Matthew D Breyer; Richard M Breyer
Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor.
Nature medicine 1999;5(2):217-20.
1999: David W Piston; Susan M Knobel; C Postic; Kathy D Shelton; Mark Magnuson
Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion.
The Journal of biological chemistry 1999;274(2):1000-4.
1999: C Postic; Mark Magnuson
[Role of glucokinase (GK) in the maintenance of glucose homeostasis. Specific disruption of the gene by the Cre-loxP technique].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1999;():115-24.
1999: C Postic; Masakazu Shiota; Kevin D Niswender; Thomas L Jetton; Yan Chen; JM Moates; Kathy D Shelton; Jill Lindner; Alan D Cherrington; Mark Magnuson
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
The Journal of biological chemistry 1999;274(1):305-15.
1998: C D Weaver; John G Partridge; T L Yao; JM Moates; Mark Magnuson; TA Verdoorn
Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreas.
Molecular pharmacology 1998;54(4):639-46.
1998: Thomas L Jetton; JM Moates; Jill Lindner; Christopher V E Wright; Mark Magnuson
Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8654-9.
1998: SO Castillo; JS Baffi; Miklós Palkovits; David S Goldstein; I J Kopin; Jassir Witta; Mark Magnuson; Vera M Nikodem
Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene.
Molecular and cellular neurosciences 1998;11(1-2):36-46.
1998: Franz M Matschinsky; Benjamin Glaser; Mark Magnuson
Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.
Diabetes 1998;47(3):307-15.
1997: Shimian Qu; Kevin D Niswender; Q Ji; R van der Meer; Diane S Keeney; Mark Magnuson; Ron Wisdom
Polydactyly and ectopic ZPA formation in Alx-4 mutant mice.
Development (Cambridge, England) 1997;124(20):3999-4008.
1997: JM Moates; C Postic; J F Decaux; J Girard; Mark Magnuson
Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene.
Genomics 1997;45(1):185-93.
1997: Kevin D Niswender; Masakazu Shiota; C Postic; Alan D Cherrington; Mark Magnuson
Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism.
The Journal of biological chemistry 1997;272(36):22570-5.
1997: Kevin D Niswender; C Postic; Thomas L Jetton; B D Bennett; David W Piston; S Efrat; Mark Magnuson
Cell-specific expression and regulation of a glucokinase gene locus transgene.
The Journal of biological chemistry 1997;272(36):22564-9.
1997: QS Ji; GE Winnier; Kevin D Niswender; DA Horstman; Ron Wisdom; Mark Magnuson; Graham Carpenter
Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2999-3003.
1997: P Kesavan; L Wang; E Davis; A Cuesta; IR Sweet; K Niswender; Mark Magnuson; Franz M Matschinsky
Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).
The Biochemical journal 1997;322 ( Pt 1)():57-63.
1997: Kevin D Niswender; C Postic; Masakazu Shiota; Thomas L Jetton; Mark Magnuson
Effects of altered glucokinase gene copy number on blood glucose homoeostasis.
Biochemical Society transactions 1997;25(1):113-7.
1996: R Wang; Leigh B MacMillan; robert fremeau; Mark Magnuson; J Lindner; Lee E Limbird
Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals.
Neuroscience 1996;74(1):199-218.
1996: JM Moates; Kathy D Shelton; Mark Magnuson
Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation.
Molecular endocrinology (Baltimore, Md.) 1996;10(6):723-31.
1996: M F Offield; Thomas L Jetton; Patricia A Labosky; M Ray; R W Stein; Mark Magnuson; Brigid L M Hogan; Christopher V E Wright
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
Development (Cambridge, England) 1996;122(3):983-95.
1996: B D Bennett; Thomas L Jetton; G Ying; Mark Magnuson; David W Piston
Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets.
The Journal of biological chemistry 1996;271(7):3647-51.
1996: R Parsa; J F Decaux; P Bossard; B R Robey; Mark Magnuson; Daryl K Granner; JEAN R GIRARD
Induction of the glucokinase gene by insulin in cultured neonatal rat hepatocytes. Relationship with DNase-I hypersensitive sites and functional analysis of a putative insulin-response element.
European journal of biochemistry / FEBS 1996;236(1):214-21.
1995: Kevin D Niswender; SCOTT BLACKMAN; L Rohde; Mark Magnuson; David W Piston
Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits.
Journal of microscopy 1995;180(Pt 2):109-16.
1995: C Postic; Kevin D Niswender; J F Decaux; R Parsa; Kathy D Shelton; B Gouhot; C C Pettepher; Daryl K Granner; JEAN R GIRARD; Mark Magnuson
Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.
Genomics 1995;29(3):740-50.
1995: C P Williams; Daryl K Granner; Mark Magnuson; Roger Chalkley
Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene.
Biochemical and biophysical research communications 1995;215(1):272-9.
1995: Y Liang; P Kesavan; L Q Wang; Kevin D Niswender; Y Tanizawa; M Alan Permutt; Mark Magnuson; Franz M Matschinsky
Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.
The Biochemical journal 1995;309 ( Pt 1)():167-73.
1994: A J Franklin; Thomas L Jetton; Kathy D Shelton; Mark Magnuson
BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.
Molecular and cellular biology 1994;14(10):6773-88.
1994: H Morita; Y Yano; Kevin D Niswender; James M May; R R Whitesell; L Wu; Richard L Printz; Daryl K Granner; Mark Magnuson; A C Powers
Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization.
The Journal of clinical investigation 1994;94(4):1373-82.
1994: Y Liang; Thomas L Jetton; E C Zimmerman; Habiba Najafi; D K Berner; Franz M Matschinsky; Mark Magnuson
Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene.
Diabetes 1994;43(9):1138-45.
1994: J Lazar; B Desvergne; E C Zimmerman; Danna Zimmer; Mark Magnuson; Vera M Nikodem
A role for intronic sequences on expression of thyroid hormone receptor alpha gene.
The Journal of biological chemistry 1994;269(32):20352-9.
1994: S Efrat; M Leiser; Y J Wu; D Fusco-DeMane; O A Emran; M Surana; Thomas L Jetton; Mark Magnuson; G Weir; Norman Fleischer
Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2051-5.
1994: Thomas L Jetton; Y Liang; C C Pettepher; E C Zimmerman; F G Cox; K Horvath; Franz M Matschinsky; Mark Magnuson
Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.
The Journal of biological chemistry 1994;269(5):3641-54.
1994: Barbara Meyrick; Mark Magnuson
Identification and functional characterization of the bovine manganous superoxide dismutase promoter.
American journal of respiratory cell and molecular biology 1994;10(1):113-21.
1993: Y Kijima; A Saito; Thomas L Jetton; Mark Magnuson; Sidney Fleischer
Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes.
The Journal of biological chemistry 1993;268(5):3499-506.
1993: Mark Magnuson; Thomas L Jetton
Evolutionary conservation of elements in the upstream glucokinase promoter.
Biochemical Society transactions 1993;21(1):160-3.
1993: Kenneth L Brigham; Barbara Meyrick; Brian W Christman; J T Conary; G King; L C Berry; Mark Magnuson
Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice.
American journal of respiratory cell and molecular biology 1993;8(2):209-13.
1993: Richard L Printz; Mark Magnuson; Daryl K Granner
Mammalian glucokinase.
Annual review of nutrition 1993;13():463-96.
1992: Kathy D Shelton; A J Franklin; Andras Khoor; Joseph M Beechem; Mark Magnuson
Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells.
Molecular and cellular biology 1992;12(10):4578-89.
1992: Y Liang; Habiba Najafi; R M Smith; E C Zimmerman; Mark Magnuson; M Tal; Franz M Matschinsky
Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture.
Diabetes 1992;41(7):792-806.
1992: Thomas L Jetton; Mark Magnuson
Heterogeneous expression of glucokinase among pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2619-23.
1992: M K Short; David E Clouthier; I M Schaefer; Robert E Hammer; Mark Magnuson; E G Beale
Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.
Molecular and cellular biology 1992;12(3):1007-20.
1992: Mark Magnuson
Tissue-specific regulation of glucokinase gene expression.
Journal of cellular biochemistry 1992;48(2):115-21.
1991: Y Liang; Thomas L Jetton; E C Zimmerman; Habiba Najafi; Franz M Matschinsky; Mark Magnuson
Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary.
The Journal of biological chemistry 1991;266(11):6999-7007.
1991: E C Zimmerman; C M Jones; V Fet; B L Hogan; Mark Magnuson
Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor.
Nucleic acids research 1991;19(4):956.
1990: Claude Forest; Richard M O'Brien; Peter C Lucas; Mark Magnuson; Daryl K Granner
Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1302-10.
1990: Richard M O'Brien; Peter C Lucas; Claude Forest; Mark Magnuson; Daryl K Granner
Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription.
Science (New York, N.Y.) 1990;249(4968):533-7.
1990: Mark Magnuson
Glucokinase gene structure. Functional implications of molecular genetic studies.
Diabetes 1990;39(5):523-7.
1990: Danna Zimmer; Mark Magnuson
Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(2):171-8.
1989: Kenneth L Brigham; Barbara Meyrick; Brian W Christman; Mark Magnuson; G King; L C Berry
In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle.
The American journal of the medical sciences 1989;298(4):278-81.
1989: Mark Magnuson; Kathy D Shelton
An alternate promoter in the glucokinase gene is active in the pancreatic beta cell.
The Journal of biological chemistry 1989;264(27):15936-42.
1989: H Morioka; Mark Magnuson; T Mitsuhashi; M K Song; Joseph Edward Rall; Vera M Nikodem
Structural characterization of the rat malic enzyme gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4912-6.
1989: Mark Magnuson; T L Andreone; Richard L Printz; S Koch; Daryl K Granner
Rat glucokinase gene: structure and regulation by insulin.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4838-42.
1989: T L Andreone; Richard L Printz; S J Pilkis; Mark Magnuson; Daryl K Granner
The amino acid sequence of rat liver glucokinase deduced from cloned cDNA.
The Journal of biological chemistry 1989;264(1):363-9.
1989: Vera M Nikodem; Mark Magnuson; B Dozin; H Morioka
Coding nucleotide sequence of rat malic enzyme mRNA and tissue specific regulation by thyroid hormone.
Endocrine research 1989;15(4):547-64.
1988: P G Quinn; T W Wong; Mark Magnuson; J B Shabb; Daryl K Granner
Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene.
Molecular and cellular biology 1988;8(8):3467-75.
1988: D D Petersen; Mark Magnuson; Daryl K Granner
Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene.
Molecular and cellular biology 1988;8(1):96-104.
1987: Mark Magnuson; P G Quinn; Daryl K Granner
Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone.
The Journal of biological chemistry 1987;262(31):14917-20.
1986: M F Tecce; B Dozin; Mark Magnuson; Vera M Nikodem
Transcriptional regulation by thyroid hormone of an mRNA homologous to a protease inhibitor.
Biochemistry 1986;25(19):5831-4.
1986: B Dozin; Mark Magnuson; Vera M Nikodem
Thyroid hormone regulation of malic enzyme synthesis. Dual tissue-specific control.
The Journal of biological chemistry 1986;261(22):10290-2.
1986: Mark Magnuson; H Morioka; M F Tecce; Vera M Nikodem
Coding nucleotide sequence of rat liver malic enzyme mRNA.
The Journal of biological chemistry 1986;261(3):1183-6.
1985: B Dozin; Mark Magnuson; Vera M Nikodem
Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine.
Biochemistry 1985;24(20):5581-6.
1985: Mark Magnuson; B Dozin; Vera M Nikodem
Regulation of specific rat liver messenger ribonucleic acids by triiodothyronine.
The Journal of biological chemistry 1985;260(10):5906-12.
1983: Mark Magnuson; V M Nikodem
Molecular cloning of a cDNA sequence for rat malic enzyme. Direct evidence for induction in vivo of rat liver malic enzyme mRNA by thyroid hormone.
The Journal of biological chemistry 1983;258(20):12712-7.
1975: J D Olson; W J Brockway; D N Fass; Mark Magnuson; E J Bowie
Evaluation of ristocetin-Willebrand factor assay and ristocetin-induced platelet aggregation.
American journal of clinical pathology 1975;63(2):210-8.