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Shinichi Koizumi

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Osamu Irie; Takatoshi Kosaka; Takeru Ehara; Fumiaki Yokokawa; Takanori Kanazawa; Hajime Hirao; Astuko Iwasaki; Junichi Sakaki; Naoki Teno; Yuko Hitomi; Genji Iwasaki; Hiroaki Fukaya; Kazuhiko Nonomura; Keiko Tanabe; Shinichi Koizumi; Noriko Uchiyama; Stuart Bevan; Marzia Malcangio; Clive Gentry; Alyson J Fox; Mohammed Yaqoob; Andrew J Culshaw
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.
Yuka Shanado; Motohiko Kometani; Hidefumi Uchiyama; Shinichi Koizumi; Naoki Teno
Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach.
Masashi Yamada; Tadahiro Numakawa; Hisatsugu Koshimizu; Keiko Tanabe; Kazuyo Wada; Shinichi Koizumi; Hiroshi Hatanaka
Distinct usages of phospholipase C gamma and Shc in intracellular signaling stimulated by neurotrophins.

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All Publications

2008: Osamu Irie; Takatoshi Kosaka; Takeru Ehara; Fumiaki Yokokawa; Takanori Kanazawa; Hajime Hirao; Astuko Iwasaki; Junichi Sakaki; Naoki Teno; Yuko Hitomi; Genji Iwasaki; Hiroaki Fukaya; Kazuhiko Nonomura; Keiko Tanabe; Shinichi Koizumi; Noriko Uchiyama; Stuart Bevan; Marzia Malcangio; Clive Gentry; Alyson J Fox; Mohammed Yaqoob; Andrew J Culshaw
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.
Journal of medicinal chemistry 2008;51(18):5502-5.
2004: Yuka Shanado; Motohiko Kometani; Hidefumi Uchiyama; Shinichi Koizumi; Naoki Teno
Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach.
Biochemical and biophysical research communications 2004;325(4):1487-94.
2002: Masashi Yamada; Tadahiro Numakawa; Hisatsugu Koshimizu; Keiko Tanabe; Kazuyo Wada; Shinichi Koizumi; Hiroshi Hatanaka
Distinct usages of phospholipase C gamma and Shc in intracellular signaling stimulated by neurotrophins.
Brain research 2002;955(1-2):183-90.
2002: Shingo Suzuki; Masaharu Mizutani; Kenji Suzuki; Masashi Yamada; Masami Kojima; Hiroshi Hatanaka; Shinichi Koizumi
Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.
Biochemical and biophysical research communications 2002;294(5):1087-92.
2002: Shinya Amino; Makoto Itakura; Hiroshi Ohnishi; Jun Tsujimura; Shinichi Koizumi; Nobuyuki Takei; Masami Takahashi
Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca(2+)-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
Journal of biochemistry 2002;131(6):887-94.
2002: Takeshi Nakamura; Misako Komiya; Noriko Gotoh; Shinichi Koizumi; Masabumi Shibuya; Nozomu Mori
Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules.
Oncogene 2002;21(1):22-31.
2002: Kenji Suzuki; Masaharu Mizutani; Yoshiaki Hitomi; Takako Kizaki; Hideki Ohno; Hitoshi Ishida; Shukoh Haga; Shinichi Koizumi
Association of SH2-B to phosphorylated tyrosine residues in the activation loop of TrkB.
Research communications in molecular pathology and pharmacology 2002;111(1-4):27-39.
2001: Masashi Yamada; K Tanabe; Koichiro Wada; Koji Shimoke; Yasuyuki Ishikawa; Toshihiko Ikeuchi; Shinichi Koizumi; Hiroshi Hatanaka
Differences in survival-promoting effects and intracellular signaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons.
Journal of neurochemistry 2001;78(5):940-51.
2001: Masashi Yamada; Keiichiro Suzuki; M Mizutani; A Asada; Takashi Matozaki; Toshihiko Ikeuchi; Shinichi Koizumi; Hiroshi Hatanaka
Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.
Journal of biochemistry 2001;130(1):157-65.
2000: Makoto Takahashi; O Shirakawa; Kazuhiko Toyooka; N Kitamura; T Hashimoto; K Maeda; Shinichi Koizumi; K Wakabayashi; Hitoshi Takahashi; Toshiyuki Someya; Hiroyuki Nawa
Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients.
Molecular psychiatry 2000;5(3):293-300.
1998: Y Iwasaki; B Gay; K Wada; Shinichi Koizumi
Association of the Src family tyrosine kinase Fyn with TrkB.
Journal of neurochemistry 1998;71(1):106-11.
1997: B A Goldsmith; Shinichi Koizumi
Transient association of the phosphotyrosine phosphatase SHP-2 with TrkA is induced by nerve growth factor.
Journal of neurochemistry 1997;69(3):1014-9.
1997: Toshiaki Kume; H Kouchiyama; S Kaneko; T Maeda; Shuji Kaneko; Akinori Akaike; Shun Shimohama; Takeshi Kihara; Jun Kimura; K Wada; Shinichi Koizumi
BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons.
Brain research 1997;756(1-2):200-4.
1997: Y Iwasaki; H Nishiyama; K Suzuki; Shinichi Koizumi
Sequential cis/trans autophosphorylation in TrkB tyrosine kinase.
Biochemistry 1997;36(9):2694-700.
1996: N Okada; K Wada; B A Goldsmith; Shinichi Koizumi
SHP-2 is involved in neurotrophin signaling.
Biochemical and biophysical research communications 1996;229(2):607-11.
1996: K Wada; N Okada; T Yamamura; Shinichi Koizumi
Nerve growth factor induces resistance of PC12 cells to nitric oxide cytotoxicity.
Neurochemistry international 1996;29(5):461-7.
1996: Norio Kaneda; A H Talukder; H Nishiyama; Shinichi Koizumi; Takashi Muramatsu
Midkine, a heparin-binding growth/differentiation factor, exhibits nerve cell adhesion and guidance activity for neurite outgrowth in vitro.
Journal of biochemistry 1996;119(6):1150-6.
1995: N Okada; Shinichi Koizumi
A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells.
The Journal of biological chemistry 1995;270(27):16464-9.
1991: D L Simpson; G Dickens; S Doll; Shinichi Koizumi; M Tocco; O Okuda; M Oshima; B B Rudkin; M Brightman; Gordon Guroff
Differentiation of PC12 cells with K-ras: comparison with nerve growth factor.
Journal of neuroscience research 1991;28(4):486-96.
1990: B Nikodijevic; C R Creveling; Shinichi Koizumi; Gordon Guroff
Nerve growth factor and K-252a increase catecholamine release from PC12 cells.
Journal of neuroscience research 1990;26(3):288-95.
1989: M Oshima; Shinichi Koizumi; K Fujita; Gordon Guroff
Nerve growth factor-induced decrease in the calpain activity of PC12 cells.
The Journal of biological chemistry 1989;264(34):20811-6.
1989: Dianne M Rausch; G Dickens; S Doll; K Fujita; Shinichi Koizumi; B B Rudkin; M Tocco; Lee E Eiden; Gordon Guroff
Differentiation of PC12 cells with v-src: comparison with nerve growth factor.
Journal of neuroscience research 1989;24(1):49-58.
1989: Shinichi Koizumi; A Ryazanov; T Hama; Hao-Chia Chen; Gordon Guroff
Identification of Nsp100 as elongation factor 2 (EF-2).
FEBS letters 1989;253(1-2):55-8.
1989: Philip Lazarovici; Ben-Zion Levi; Peter Lelkes; Shinichi Koizumi; K Fujita; Y Matsuda; Keiko Ozato; Gordon Guroff
K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells.
Journal of neuroscience research 1989;23(1):1-8.
1988: Tatsuro Mutoh; B B Rudkin; Shinichi Koizumi; Gordon Guroff
Nerve growth factor, a differentiating agent, and epidermal growth factor, a mitogen, increase the activities of different S6 kinases in PC12 cells.
The Journal of biological chemistry 1988;263(31):15853-6.
1988: M D Tocco; M L Contreras; Shinichi Koizumi; G Dickens; Gordon Guroff
Decreased levels of nerve growth factor receptor on dexamethasone-treated PC12 cells.
Journal of neuroscience research 1988;20(4):411-9.
1988: Shinichi Koizumi; M L Contreras; Y Matsuda; T Hama; Philip Lazarovici; Gordon Guroff
K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(2):715-21.
1988: Shinichi Koizumi; F Tanaka; N Kaneda; K Kano; T Nagatsu
Nanosecond pulse fluorometry of conformational change in phenylalanine hydroxylase associated with activation.
Biochemistry 1988;27(2):640-6.
1987: Shinichi Koizumi; T Suzuki; S Takahashi; K Satake; T Takeuchi; H Umezawa; Toshiharu Nagatsu
Sulfhydryl modification and activation of phenylalanine hydroxylase by dinitrophenyl alkyl disulfide.
Biochemistry 1987;26(20):6461-5.
1986: Shinichi Koizumi; T Takeuchi; H Umezawa; T Nagatsu
Immobilized phenylalanine hydroxylase through the SH groups.
Biotechnology and bioengineering 1986;28(4):620-3.
1984: Shinichi Koizumi; Y Matsushima; Toshiharu Nagatsu; H Iinuma; T Takeuchi; H Umezawa
3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases.
Biochimica et biophysica acta 1984;789(2):111-8.
1982: Shinichi Koizumi; T Nagatsu; H Iinuma; M Ohno; T Takeuchi; H Umezawa
Inhibition of phenylalanine hydroxylase, a pterin-requiring monooxygenase, by oudenone and its derivatives.
The Journal of antibiotics 1982;35(4):458-62.