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Yong-Yu Liu

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Akhtar Siddiqui; Vineet Gupta; Yong-Yu Liu; Sami Nazzal
Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).
Yong-Yu Liu; Gauri A Patwardhan; Ping Xie; Armando E Giuliano; Xin Gu; Myles C Cabot
Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma.
Yong-Yu Liu; Gauri A Patwardhan; Kaustubh Bhinge; Vineet Gupta; Xin Gu; S Michal Jazwinski
Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.

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All Publications

2012: Akhtar Siddiqui; Vineet Gupta; Yong-Yu Liu; Sami Nazzal
Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).
International journal of pharmaceutics 2012;431(1-2):222-9.
2011: Yong-Yu Liu; Gauri A Patwardhan; Ping Xie; Armando E Giuliano; Xin Gu; Myles C Cabot
Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma.
International journal of oncology 2011;39(2):425-31.
2011: Yong-Yu Liu; Gauri A Patwardhan; Kaustubh Bhinge; Vineet Gupta; Xin Gu; S Michal Jazwinski
Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.
Cancer research 2011;71(6):2276-85.
2011: Fei Wang; Jianfeng Liu; Delira Robbins; Kerri Morris; Amos Sit; Yong-Yu Liu; Yunfeng Zhao
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells.
Apoptosis : an international journal on programmed cell death 2011;16(3):301-10.
2011: Vineet Gupta; Qian-Jin Zhang; Yong-Yu Liu
Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells.
Methods in molecular biology (Clifton, N.J.) 2011;716():179-91.
2011: Gauri A Patwardhan; Yong-Yu Liu
Sphingolipids and expression regulation of genes in cancer.
Progress in lipid research 2011;50(1):104-14.
2010: Akhtar Siddiqui; Gauri Anand Patwardhan; Yong-Yu Liu; Sami Nazzal
Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells.
International journal of pharmaceutics 2010;400(1-2):251-9.
2010: Jacqueline V Chapman; Valérie Gouazé-Andersson; Maria C Messner; Margaret Flowers; Ramin Karimi; Mark Kester; Brian M Barth; Xin Liu; Yong-Yu Liu; Armando E Giuliano; Myles C Cabot
Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches.
Biochemical pharmacology 2010;80(3):308-15.
2010: Gauri Patwardhan; Vineet Gupta; Juowen Huang; Xin Gu; Yong-Yu Liu
Direct assessment of P-glycoprotein efflux to determine tumor response to chemotherapy.
Biochemical pharmacology 2010;80(1):72-9.
2010: Vineet Gupta; Gauri A Patwardhan; Qian-Jin Zhang; Myles C Cabot; S Michal Jazwinski; Yong-Yu Liu
Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.
Journal of lipid research 2010;51(4):866-74.
2010: Yong-Yu Liu; Vineet Gupta; Gauri A Patwardhan; Kaustubh Bhinge; Yunfeng Zhao; Jianxiong Bao; Harihara Mehendale; Myles C Cabot; Yu-Teh Li; S Michal Jazwinski
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.
Molecular cancer 2010;9():145.
2009: Gauri A Patwardhan; Qian-Jin Zhang; Dongmei Yin; Vineet Gupta; Jianxiong Bao; Can E Senkal; Besim Ogretmen; Myles C Cabot; Girish Shah; Paul W Sylvester; S Michal Jazwinski; Yong-Yu Liu
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis.
PloS one 2009;4(9):e6938.
2009: Xiao-Lin Li; Yong-Yu Liu; David Knight; Yoshinobu Odaka; J Michael Mathis; Runhua Shi; Jonathan Glass; Qian-Jin Zhang
Effect of B7.1 costimulation on T-cell based immunity against TAP-negative cancer can be facilitated by TAP1 expression.
PloS one 2009;4(7):e6385.
2008: Hongtao Wang; Barry J Maurer; Yong-Yu Liu; Elaine Wang; Jeremy C Allegood; Samuel Kelly; Holly Symolon; Ying Liu; Alfred H Merrill; Valérie Gouazé-Andersson; Jing Yuan Yu; Armando E Giuliano; Myles C Cabot
N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.
Molecular cancer therapeutics 2008;7(9):2967-76.
2008: Yong-Yu Liu; Jing Yuan Yu; Dongmei Yin; Gauri Anand Patwardhan; Vineet Gupta; Yoshio Hirabayashi; Walter M Holleran; Armando E Giuliano; S Michal Jazwinski; Valerie Gouaze-Andersson; David P Consoli; Myles C Cabot
A role for ceramide in driving cancer cell resistance to doxorubicin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2541-51.
2008: Xiao-Lin Li; Dong-Qing Zhang; David Wang; David S Knight; Lija Yin; Jianxiong Bao; Yong-Yu Liu; Jonathan Glass; J Michael Mathis; Qian-Jin Zhang
In vivo survivors of transformed mouse ovarian surface epithelial cells display diverse phenotypes for gene expression and tumorigenicity.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2008;29(6):359-70.
2005: Valérie Gouazé; Yong-Yu Liu; Carlton S Prickett; Jing Y Yu; Armando E Giuliano; Myles C Cabot
Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs.
Cancer research 2005;65(9):3861-7.
2004: Valérie Gouazé; Jing Y Yu; Richard J Bleicher; Tieyan Han; Yong-Yu Liu; Hongtao Wang; Michael M Gottesman; Arie Bitterman; Armando E Giuliano; Myles C Cabot
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.
Molecular cancer therapeutics 2004;3(5):633-9.
2004: Yong-Yu Liu; Tieyan Han; Jing Y Yu; Arie Bitterman; Ahn Le; Armando E Giuliano; Myles C Cabot
Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.
Journal of lipid research 2004;45(5):933-40.
2004: Yong-Yu Liu; Myles C Cabot
Development of a mammalian Tet-on expression cell line: glucosylceramide synthase regulates TNF-alpha-induced apoptosis.
Methods in molecular biology (Clifton, N.J.) 2004;249():177-92.
2002: Arie Bitterman; Richard J Bleicher; Myles C Cabot; Yong-Yu Liu; Armando E Giuliano
Sentinel lymphadenectomy: a new alternative for managing early breast cancer.
The Israel Medical Association journal : IMAJ 2002;4(10):803-9.
2001: A G Charles; Tieyan Han; Yong-Yu Liu; N Hansen; Armando E Giuliano; Myles C Cabot
Taxol-induced ceramide generation and apoptosis in human breast cancer cells.
Cancer chemotherapy and pharmacology 2001;47(5):444-50.
2001: Yong-Yu Liu; Tieyan Han; Armando E Giuliano; Myles C Cabot
Ceramide glycosylation potentiates cellular multidrug resistance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):719-30.
2000: Yong-Yu Liu; Tieyan Han; Armando E Giuliano; N Hansen; Myles C Cabot
Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance.
The Journal of biological chemistry 2000;275(10):7138-43.
1999: Yong-Yu Liu; Tieyan Han; Armando E Giuliano; S Ichikawa; Y Hirabayashi; Myles C Cabot
Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis.
Experimental cell research 1999;252(2):464-70.
1999: A Lucci; Tieyan Han; Yong-Yu Liu; Armando E Giuliano; Myles C Cabot
Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics.
International journal of oncology 1999;15(3):541-6.
1999: A Lucci; Armando E Giuliano; Tieyan Han; T Dinur; Yong-Yu Liu; A Senchenkov; Myles C Cabot
Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells.
International journal of oncology 1999;15(3):535-40.
1999: A Lucci; Tieyan Han; Yong-Yu Liu; Armando E Giuliano; Myles C Cabot
Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells.
Cancer 1999;86(2):300-11.
1999: Yong-Yu Liu; K Rajkumar; Liam J Murphy
Hepatic regeneration in insulin-like growth factor binding protein-1 transgenic mice.
Journal of hepatology 1999;30(4):674-80.
1999: Myles C Cabot; Armando E Giuliano; Tieyan Han; Yong-Yu Liu
SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells.
Cancer research 1999;59(4):880-5.
1999: Yong-Yu Liu; Tieyan Han; Armando E Giuliano; Myles C Cabot
Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.
The Journal of biological chemistry 1999;274(2):1140-6.
1998: Y Lavie; Z C Zhang; H T Cao; Tieyan Han; R C Jones; Yong-Yu Liu; Michael Jarman; IR Hardcastle; Armando E Giuliano; Myles C Cabot
Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF-7 human breast cancer cells.
International journal of cancer. Journal international du cancer 1998;77(6):928-32.
1996: H Valensise; Yong-Yu Liu; Massimo Federici; Davide Lauro; D Dell'anna; C Romanini; Giorgio Sesti
Increased expression of low-affinity insulin receptor isoform and insulin/insulin-like growth factor-I hybrid receptors in term placenta from insulin-resistant women with gestational hypertension.
Diabetologia 1996;39(8):952-60.
1996: Giorgio Sesti; R D'Alfonso; M D Vargas Punti; A N Tullio; Yong-Yu Liu; Massimo Federici; P Borboni; MA Marini; Renato Lauro; Angelo Fusco
Delayed intracellular dissociation of the insulin-receptor complex impairs receptor recycling and insulin processing in cultured Epstein-Barr virus-transformed lymphocytes from insulin-resistant subjects.
Diabetologia 1996;39(3):289-95.
1995: Giorgio Sesti; R D'Alfonso; M D Vargas Punti; Lucia Frittitta; Vincenzo Trischitta; Yong-Yu Liu; P Borboni; R Longhi; A Montemurro; Renato Lauro
Peptide-based radioimmunoassay for the two isoforms of the human insulin receptor.
Diabetologia 1995;38(4):445-53.