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Filippo Caraci

Research Profile

Disorders

Alzheimer's Disease

Anatomy

Chemicals & Drugs

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Sicily

Physiology

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Publications

TOP 3
Filippo Caraci; Filippo Drago; Gian Marco Leggio; Salvatore Salomone
Epigenetic drugs for Alzheimer's disease: hopes and challenges.
Luisa Di Menna; Luigi Di Nuzzo; Gemma Molinaro; Ferdinando Nicoletti; Carlo Pozzilli; Barbara Riozzi; Renato Turrini; Cristina Zappulla; Giuseppe Battaglia; Filippo Caraci; Agata Copani; Valeria Bruno
Fingolimod protects cultured cortical neurons against excitotoxic death.
Maria Laura Giuffrida; Ferdinando Nicoletti; Flora Tomasello; Filippo Caraci; Santina Chiechio; Agata Copani
Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease.

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All Publications

2013: Filippo Caraci; Filippo Drago; Gian Marco Leggio; Salvatore Salomone
Epigenetic drugs for Alzheimer's disease: hopes and challenges.
British journal of clinical pharmacology 2013;75(4):1154-5.
2013: Luisa Di Menna; Luigi Di Nuzzo; Gemma Molinaro; Ferdinando Nicoletti; Carlo Pozzilli; Barbara Riozzi; Renato Turrini; Cristina Zappulla; Giuseppe Battaglia; Filippo Caraci; Agata Copani; Valeria Bruno
Fingolimod protects cultured cortical neurons against excitotoxic death.
Pharmacological research : the official journal of the Italian Pharmacological Society 2013;67(1):1-9.
2012: Maria Laura Giuffrida; Ferdinando Nicoletti; Flora Tomasello; Filippo Caraci; Santina Chiechio; Agata Copani
Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease.
Molecular neurobiology 2012;46(3):605-13.
2012: Filippo Caraci; Agata Copani; Gemma Molinaro; Ferdinando Nicoletti; Maria Angela Sortino; Simona Spampinato; Giuseppe Battaglia; Valeria Bruno
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?
Neurochemistry international 2012;61(4):559-65.
2012: Salvatore Salomone; Filippo Caraci; Julia Fedotova; Gian Marco Leggio; Filippo Drago
New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.
British journal of clinical pharmacology 2012;73(4):504-17.
2012: Filippo Caraci; Agata Copani; Filomena I Cosentino; Filippo Drago; Eugenio Aguglia; Cinzia Bonforte; Paolo Bosco; Maria Concetta Giambirtone; Eleonora Gulotta; Stefano Muratore; Ferdinando Nicoletti; Simonetta Panerai; Giuseppina Prestianni; Carmelo Romano; Maria Grazia Salluzzo; Maria Signorelli; Rosario S Spada; Giuseppe Toscano; Raffaele Ferri
The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2012;22(4):281-9.
2012: Mauro Giovanni Carta; Liliana Dell'osso; Guido Di Sciascio; Filippo Drago; Carlo Faravelli; Eugenio Aguglia; Matteo Balestrieri; Joseph R Calabrese; Filippo Caraci; Maria Efisia Lecca; Maria Francesca Moro; Marcello Nardini; Gabriella Palumbo; maria carolina hardoy
The lifetime prevalence of bipolar disorders and the use of antidepressant drugs in bipolar depression in Italy.
Journal of affective disorders 2012;136(3):775-80.
2012: Mauro Giovanni Carta; Massimo Casacchia; Liliana Dell'osso; Filippo Drago; Carlo Faravelli; Emilio Del Giudice; maria carolina hardoy; Maria Efisia Lecca; Maria Francesca Moro; Guido Di Sciascio; Eugenio Aguglia; Matthias Angermeyer; Salvatore Calò; Filippo Caraci; Matteo Balestrieri
Quality of life and urban / rural living: preliminary results of a community survey in Italy.
Clinical practice and epidemiology in mental health : CP & EMH 2012;8():169-74.
2012: Michele Salemi; Roberto Salluzzo; Cataldo Scavuzzo; Francesco Scillato; Aldo E Calogero; Filippo Caraci; Federico Ridolfo; Carmelo Romano; Corrado Romano; Concetta Barone; Paolo Bosco
Expression of LDOC1 mRNA in leucocytes of patients with Down's syndrome.
Journal of genetics 2012;91(1):95-8.
2011: Filippo Caraci; Viviana Carbonaro; Giuseppe Battaglia; Paolo Bosco; Valeria Bruno; Filippo Drago; Maria Laura Giuffrida; Ferdinando Nicoletti; Maria Angela Sortino; Agata Copani
TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease.
CNS neuroscience & therapeutics 2011;17(4):237-49.
2011: Filippo Caraci; Rosalia Crupi; Filippo Drago; Edoardo Spina
Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract.
Current drug metabolism 2011;12(6):570-7.
2011: Filippo Caraci; Venerando Pistarà; A Corsaro; Flora Tomasello; Maria Laura Giuffrida; Maria Angela Sortino; Ferdinando Nicoletti; Agata Copani
Neurotoxic properties of the anabolic androgenic steroids nandrolone and methandrostenolone in primary neuronal cultures.
Journal of neuroscience research 2011;89(4):592-600.
2011: Filippo Caraci; Gemma Molinaro; Giuseppe Battaglia; Maria Laura Giuffrida; Barbara Riozzi; Anna Traficante; Valeria Bruno; Milena Cannella; Sara Merlo; Xushan Wang; Beverly A Heinz; Eric S Nisenbaum; Thomas C Britton; Filippo Drago; Maria Angela Sortino; Agata Copani; Ferdinando Nicoletti
Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.
Molecular pharmacology 2011;79(3):618-26.
2011: Mauro Giovanni Carta; Massimo Casacchia; Liliana Dell'osso; Guido Di Sciascio; Carlo Faravelli; maria carolina hardoy; Maria E Lecca; Maria Francesca Moro; Leonardo Tondo; Matteo Balestrieri; Krishna M Bhat; Filippo Caraci; Filippo Drago
Sub-threshold depression and antidepressants use in a community sample: searching anxiety and finding bipolar disorder.
BMC psychiatry 2011;11():164.
2011: Enrico Conte; Nunzio Crimi; Evelina Fagone; Mary Fruciano; Elisa Gili; Maria Iemmolo; Filippo Caraci; Carlo Vancheri
Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms.
PloS one 2011;6(10):e24663.
2011: Francesco Matrisciano; Carla L Busceti; Domenico Bucci; Rosamaria Orlando; Alessandra Caruso; Gemma Molinaro; Irene Cappuccio; Barbara Riozzi; Roberto Gradini; Marta Motolese; Filippo Caraci; Agata Copani; Sergio Scaccianoce; Daniela Melchiorri; Valeria Bruno; Giuseppe Battaglia; Ferdinando Nicoletti
Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.
PloS one 2011;6(1):e16447.
2010: Siegfried Kasper; Filippo Caraci; Bruno Forti; Filippo Drago; Eugenio Aguglia
Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010;20(11):747-65.
2010: Filippo Caraci; Agata Copani; Ferdinando Nicoletti; Filippo Drago
Depression and Alzheimer's disease: neurobiological links and common pharmacological targets.
European journal of pharmacology 2010;626(1):64-71.
2010: Mauro Giovanni Carta; Eugenio Aguglia; Alberto Bocchetta; Matteo Balestrieri; Filippo Caraci; Massimo Casacchia; Liliana Dell'osso; Guido Di Sciascio; Filippo Drago; Carlo Faravelli; Maria Efisia Lecca; Maria Francesca Moro; Pier Luigi Morosini; Marcello Nardini; Gabriella Palumbo; maria carolina hardoy
The use of antidepressant drugs and the lifetime prevalence of major depressive disorders in Italy.
Clinical practice and epidemiology in mental health : CP & EMH 2010;6():94-100.
2010: Mario Giuffrida; Filippo Caraci; P De Bona; Giuseppe Pappalardo; Ferdinando Nicoletti; Enrico Rizzarelli; Agata Copani
The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology.
Reviews in the neurosciences 2010;21(2):83-93.
2009: Maria Laura Giuffrida; Filippo Caraci; Bruno Pignataro; Sebastiano Cataldo; Paolo De Bona; Valeria Bruno; Gemma Molinaro; Giuseppe Pappalardo; Angela Messina; Angelo Palmigiano; Domenico Garozzo; Ferdinando Nicoletti; Enrico Rizzarelli; Agata Copani
Beta-amyloid monomers are neuroprotective.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(34):10582-7.
2009: Michele Salemi; Corrado Romano; Concetta Barone; Francesco Calí; Filippo Caraci; Corrado Romano; Cataldo Scavuzzo; Francesco Scillato; Maria Grazia Salluzzo; Maria Piccione; Manuela Martines; Giovanni Corsello; Ferdinando Nicoletti; Paolo Bosco
SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes.
Journal of genetics 2009;88(1):93-7.
2009: Paolo De Bona; Maria Laura Giuffrida; Filippo Caraci; Agata Copani; Bruno Pignataro; Francesco Attanasio; Sebastiano Cataldo; Giuseppe Pappalardo; Enrico Rizzarelli
Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Abeta(1-42) fibrillogenesis and toxicity.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(3):220-8.
2009: Viviana Carbonaro; Filippo Caraci; Maria Laura Giuffrida; Sara Merlo; Pier Luigi Canonico; Filippo Drago; Agata Copani; Maria Angela Sortino
Enhanced expression of ERalpha in astrocytes modifies the response of cortical neurons to beta-amyloid toxicity.
Neurobiology of disease 2009;33(3):415-21.
2009: Salvatore Salomone; Filippo Caraci; Anna Capasso
Migraine: an overview.
The open neurology journal 2009;3():64-71.
2009: Santina Chiechio; M Zammataro; Filippo Caraci; Liborio Rampello; Agata Copani; A F Sabato; F Nicoletti
Pregabalin in the treatment of chronic pain: an overview.
Clinical drug investigation 2009;29(3):203-13.
2008: Filippo Caraci; Carla Busceti; Francesca Biagioni; Eleonora Aronica; Federica Mastroiacovo; Irene Cappuccio; Giuseppe Battaglia; Valeria Bruno; Andrea Caricasole; Agata Copani; Ferdinando Nicoletti
The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.
Neurochemical research 2008;33(12):2401-6.
2008: F I I Cosentino; Paolo Bosco; Valeria Drago; Giuseppina Prestianni; Bartolo Lanuzza; Ivan Iero; Mariangela Tripodi; Rosario S Spada; G Toscano; Filippo Caraci; Raffaele Ferri
The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea.
Sleep medicine 2008;9(8):831-9.
2008: Filippo Caraci; Giuseppe Battaglia; Carla Busceti; Francesca Biagioni; Federica Mastroiacovo; Paolo Bosco; Filippo Drago; Ferdinando Nicoletti; Maria Angela Sortino; Agata Copani
TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.
Neurobiology of disease 2008;30(2):234-42.
2008: Filippo Caraci; Elisa Gili; marco calafiore; Marco Failla; Cristina La Rosa; Nunzio Crimi; Maria Angela Sortino; Ferdinando Nicoletti; Agata Copani; Carlo Vancheri
TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.
Pharmacological research : the official journal of the Italian Pharmacological Society 2008;57(4):274-82.
2007: Paolo Bosco; Filippo Caraci; Agata Copani; Rosario S Spada; Maria Angela Sortino; Roberto Salluzzo; Michele Salemi; Ferdinando Nicoletti; Raffaele Ferri
The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily.
Neuroscience letters 2007;419(3):195-8.
2007: Agata Copani; Filippo Caraci; Jeroen J M Hoozemans; marco calafiore; Maria Angela Sortino; Ferdinando Nicoletti
The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death.
Biochimica et biophysica acta 2007;1772(4):409-12.
2007: Michele Salemi; Corrado Romano; Letizia Ragusa; Giuseppa Di Vita; Roberto Salluzzo; Ileana Oteri; Maria Luisa Trovato; Corrado Romano; Filippo Caraci; Ferdinando Nicoletti; Paolo Bosco
A new 6-bp SOX-3 polyalanine tract deletion does not segregate with mental retardation.
Genetic testing 2007;11(2):124-7.
2006: Carla Scali; Filippo Caraci; Marco Gianfriddo; Enrica Diodato; Renza Roncarati; Giuseppe Pollio; Giovanni Gaviraghi; Agata Copani; Ferdinando Nicoletti; Georg C Terstappen; Andrea Caricasole
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.
Neurobiology of disease 2006;24(2):254-65.
2006: Agata Copani; Jeroen J M Hoozemans; Filippo Caraci; marco calafiore; Elise S van Haastert; Robert Veerhuis; Annemieke J M Rozemuller; Eleonora Aronica; Maria Angela Sortino; Ferdinando Nicoletti
DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(43):10949-57.
2006: Paolo Bosco; Rosa-Maria Guéant-Rodriguez; Guido Anello; Rosario S Spada; Antonino Romano; Adrian Fajardo; Filippo Caraci; Raffaele Ferri; Jean-Louis Guéant
Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily.
Thrombosis and haemostasis 2006;96(2):154-9.
2006: Alessandra Caruso; Marta Motolese; Luisa Iacovelli; Filippo Caraci; Agata Copani; Ferdinando Nicoletti; Georg C Terstappen; Giovanni Gaviraghi; Andrea Caricasole
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.
Journal of neurochemistry 2006;98(2):364-71.
2006: marco calafiore; Giuseppe Battaglia; Agata Zappalà; Elisa Trovato-Salinaro; Filippo Caraci; Massimo Caruso; Carlo Vancheri; Maria Angela Sortino; Ferdinando Nicoletti; Agata Copani
Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid.
Neurobiology of aging 2006;27(4):606-13.
2005: Paolo Bosco; Rosa-Maria Guéant-Rodríguez; Guido Anello; Rosario S Spada; Antonino Romano; Filippo Caraci; Raffaele Ferri; Jean-Louis Guéant
Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy.
Neuroscience letters 2005;388(3):168-72.
2005: Agostino Marrazzo; Filippo Caraci; Elisa Trovato Salinaro; Tsung-Ping Su; Agata Copani; Giuseppe Ronsisvalle
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.
Neuroreport 2005;16(11):1223-6.
2005: Filippo Caraci; Mariangela Chisari; giuseppina frasca; Pier Luigi Canonico; Angelo Battaglia; marco calafiore; Giuseppe Battaglia; Paolo Bosco; Ferdinando Nicoletti; Agata Copani; Maria Angela Sortino
Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.
Brain research 2005;1047(1):30-7.
2004: Paolo Bosco; Rosa-Maria Guéant-Rodríguez; Guido Anello; Antonino Romano; Bernard Namour; Rosario S Spada; Filippo Caraci; G Tringali; Raffaele Ferri; Jean-Louis Guéant
Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(7):1036-8.
2004: Andrea Caricasole; Agata Copani; Filippo Caraci; Eleonora Aronica; Annemieke J M Rozemuller; Alessandra Caruso; marianna storto; Giovanni Gaviraghi; Georg C Terstappen; Ferdinando Nicoletti
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(26):6021-7.
2004: Guido Anello; Rosa-Maria Guéant-Rodríguez; Paolo Bosco; Jean-Louis Guéant; Antonino Romano; Bernard Namour; Rosario S Spada; Filippo Caraci; Grégory Pourié; Jean-Luc Daval; Raffaele Ferri
Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease.
Neuroreport 2004;15(5):859-61.
2004: Alfredo Bianchi; Salvatore Salomone; Filippo Caraci; Vincenzo Pizza; Renato Bernardini; Cesare Colucci D'Amato
Role of magnesium, coenzyme Q10, riboflavin, and vitamin B12 in migraine prophylaxis.
Vitamins and hormones 2004;69():297-312.
2003: Filippo Caraci; Mariangela Chisari; giuseppina frasca; Santina Chiechio; Salvatore Salomone; Antonio Pinto; Maria Angela Sortino; Alfredo Bianchi
Effects of phenformin on the proliferation of human tumor cell lines.
Life sciences 2003;74(5):643-50.
2003: Paolo Bosco; Rosa-Maria Guéant-Rodriguez; Guido Anello; Concetta Barone; Farès Namour; Filippo Caraci; Antonino Romano; Corrado Romano; Jean-Louis Guéant
Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome.
American journal of medical genetics. Part A 2003;121A(3):219-24.
2003: Andrea Caricasole; Agata Copani; Alessandra Caruso; Filippo Caraci; Luisa Iacovelli; Maria Angela Sortino; Georg C Terstappen; Ferdinando Nicoletti
The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?
Trends in pharmacological sciences 2003;24(5):233-8.