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Erwin Van Meir

Research Profile

Disorders

Anatomy

Living Beings

Physiology

Chemicals & Drugs

Genes & Molecular Sequences

Genes, p53

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Publications

TOP 3
Shaoman Yin; Ruiwen Zhang; Zhaobin Zhang; Wei Wang; Zhibo Wang; Thomas Abbruscato; Purushotham R Boreddy; Zhengjia Chen; Rita G de Noronha; Narra Sarojini Devi; Mark M Goodman; Adnan A Jabbar; Stefan Kaluz; Jiyoung Mun; Kyriacos C Nicolaou; Jeffrey J Olson; Erwin Van Meir
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
S M Cork; Narra Sarojini Devi; Stefan Kaluz; Balveen Kaur; J H Saltz; E M Sandberg; L Cooper; Erwin Van Meir
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.
Jiyoung Mun; James P Snyder; Chalet Tan; Erwin Van Meir; Yingzhe Wang; Shaoman Yin; Deborah Culver; Narra Sarojini Devi; Adnan Abdul Jabbar; Mark M Goodman
Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.

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All Publications

2012: Shaoman Yin; Ruiwen Zhang; Zhaobin Zhang; Wei Wang; Zhibo Wang; Thomas Abbruscato; Purushotham R Boreddy; Zhengjia Chen; Rita G de Noronha; Narra Sarojini Devi; Mark M Goodman; Adnan A Jabbar; Stefan Kaluz; Jiyoung Mun; Kyriacos C Nicolaou; Jeffrey J Olson; Erwin Van Meir
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(24):6623-33.
2012: S M Cork; Narra Sarojini Devi; Stefan Kaluz; Balveen Kaur; J H Saltz; E M Sandberg; L Cooper; Erwin Van Meir
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.
Oncogene 2012;31(50):5144-52.
2012: Jiyoung Mun; James P Snyder; Chalet Tan; Erwin Van Meir; Yingzhe Wang; Shaoman Yin; Deborah Culver; Narra Sarojini Devi; Adnan Abdul Jabbar; Mark M Goodman
Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.
Journal of medicinal chemistry 2012;55(15):6738-50.
2012: Jiyoung Mun; Erwin Van Meir; Narra Sarojini Devi; Adnan Abdul Jabbar; Yuan Liu; Mark M Goodman
Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent.
Bioorganic & medicinal chemistry 2012;20(14):4590-7.
2012: Lee A D Cooper; David A Gutman; Jun Kong; Tahsin Kurc; Carlos S Moreno; Yuan Rong; Joel Saltz; Erwin Van Meir; Christina Appin; Candace Chisolm; Daniel J Brat
The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma.
The American journal of pathology 2012;180(5):2108-19.
2012: Abdessamad Zerrouqi; Daniel J Brat; Maria Febbraio; Beata Pyrzynska; Erwin Van Meir
P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.
The Journal of clinical investigation 2012;122(4):1283-95.
2012: Edjah Kweku-Ebura Nduom; Costas George Hadjipanayis; Erwin Van Meir
Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment.
Cancer journal (Sudbury, Mass.) 2012;18(1):100-6.
2011: Suazette Reid Mooring; Adnan A Jabbar; Erwin Van Meir; Yuan Liu; Narra S Devi; Hui Jin; Stefan Kaluz; Binghe Wang
Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway.
Journal of medicinal chemistry 2011;54(24):8471-89.
2011: Jun Kong; Tahsin M Kurc; Carlos S Moreno; Tony Pan; Joel Saltz; Ashish Sharma; Erwin Van Meir; Fusheng Wang; Candace Chisolm; Lee A D Cooper; Jingjing Gao; David A Gutman; Daniel J Brat
Integrative, multimodal analysis of glioblastoma using TCGA molecular data, pathology images, and clinical outcomes.
IEEE transactions on bio-medical engineering 2011;58(12):3469-74.
2011: Chalet Tan; Binghe Wang; Rita G de Noronha; Narra S Devi; Adnan A Jabbar; Stefan Kaluz; Yuan Liu; Suazette Reid Mooring; K C Nicolaou; Erwin Van Meir
Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(18):5528-32.
2011: Juliya Kalinina; Junmin Peng; James C Ritchie; Erwin Van Meir
Proteomics of gliomas: initial biomarker discovery and evolution of technology.
Neuro-oncology 2011;13(9):926-42.
2011: Dan Zhu; Paula M Vertino; Stephen B Hunter; Erwin Van Meir
Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.
Cancer research 2011;71(17):5859-70.
2011: Sarah M Cork; Erwin Van Meir
Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development.
Journal of molecular medicine (Berlin, Germany) 2011;89(8):743-52.
2011: Stefan Kaluz; Erwin Van Meir
At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop.
Journal of molecular medicine (Berlin, Germany) 2011;89(2):91-4.
2011: Abdessamad Zerrouqi; Erwin Van Meir
A conspiracy of glioma and endothelial cells to invade the normal brain.
Oncotarget 2011;2(1-2):1-4.
2010: Lee A D Cooper; Jun Kong; David A Gutman; Fusheng Wang; Sharath R Cholleti; Tony C Pan; Patrick M Widener; Ashish Sharma; Tom Mikkelsen; Adam E Flanders; Daniel L Rubin; Erwin Van Meir; Tahsin M Kurc; Carlos S Moreno; Daniel J Brat; Joel Saltz
An integrative approach for in silico glioma research.
IEEE transactions on bio-medical engineering 2010;57(10):2617-21.
2010: Rebecca C Iskow; Michael T McCabe; Ryan Mills; Spencer Torene; W Stephen Pittard; Andrew F. Neuwald; Erwin Van Meir; Paula M Vertino; Scott Devine
Natural mutagenesis of human genomes by endogenous retrotransposons.
Cell 2010;141(7):1253-61.
2010: Erwin Van Meir; Costas G Hadjipanayis; Andrew D Norden; Hui-Kuo G Shu; Patrick Y Wen; Jeffrey J Olson
Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma.
CA: a cancer journal for clinicians 2010;60(3):166-93.
2010: Philip A Klenotic; Ping Huang; Juan Palomo; Balveen Kaur; Erwin Van Meir; Michael A Vogelbaum; Maria Febbraio; Candece L Gladson; Roy L Silverstein
Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin.
The American journal of pathology 2010;176(4):2039-50.
2009: Costas G Hadjipanayis; Erwin Van Meir
Brain cancer propagating cells: biology, genetics and targeted therapies.
Trends in molecular medicine 2009;15(11):519-30.
2009: Takuhito Narita; Shaoman Yin; Christine F Gelin; Carlos S Moreno; Manuel Yepes; Kyriacos C Nicolaou; Erwin Van Meir
Identification of a novel small molecule HIF-1alpha translation inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6128-36.
2009: Costas G Hadjipanayis; Erwin Van Meir
Tumor initiating cells in malignant gliomas: biology and implications for therapy.
Journal of molecular medicine (Berlin, Germany) 2009;87(4):363-74.
2009: Yuan Rong; Vladimir E Belozerov; Carol Tucker-Burden; Gang Chen; Donald L Durden; Jeffrey J Olson; Erwin Van Meir; Nigel Mackman; Daniel J Brat
Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.
Cancer research 2009;69(6):2540-9.
2009: Atreyi Dasgupta; Baisakhi Raychaudhuri; Talat Haqqi; Richard Prayson; Erwin Van Meir; Michael Vogelbaum; Saikh Jaharul Haque
Stat3 activation is required for the growth of U87 cell-derived tumours in mice.
European journal of cancer (Oxford, England : 1990) 2009;45(4):677-84.
2009: Balveen Kaur; Sarah M Cork; Eric M Sandberg; Narra Sarojini Devi; Zhaobin Zhang; Philip A Klenotic; Maria Febbraio; Hyunsuk Shim; Hui Mao; Carol Tucker-Burden; Roy L Silverstein; Daniel J Brat; Jeffrey J Olson; Erwin Van Meir
Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.
Cancer research 2009;69(3):1212-20.
2008: Karen H Ventii; Narra Sarojini Devi; Kenneth L Friedrich; Tatiana A Chernova; Mourad Tighiouart; Erwin Van Meir; Keith Wilkinson
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
Cancer research 2008;68(17):6953-62.
2008: Hongsung Kim; Guangyong Peng; John M Hicks; Heidi L Weiss; Erwin Van Meir; Malcolm K Brenner; Patricia Yotnda
Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):599-606.
2007: Dawn E Post; Eric M Sandberg; Michele M Kyle; Narra Sarojini Devi; Daniel J Brat; Zhiheng Xu; Mourad Tighiouart; Erwin Van Meir
Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4.
Cancer research 2007;67(14):6872-81.
2007: Fatima W Khwaja; Matthew S Reed; Jeffrey J Olson; Brian J Schmotzer; G Yancey Gillespie; Abhijit Guha; Morris D Groves; Santosh kesari; jan pohl; Erwin Van Meir
Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients.
Journal of proteome research 2007;6(2):559-70.
2007: Jean-Louis Boulay; André R Miserez; Christian Zweifel; Balasubramanian Sivasankaran; Veronika Kana; Anthony Ghaffari; Cordelia Luyken; Michael S Sabel; Abdessamad Zerrouqi; Morten Wasner; Erwin Van Meir; Markus Tolnay; Guido Reifenberger; Adrian Merlo
Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumors.
PloS one 2007;2(6):e576.
2006: Seung-Hee Kang; Heidi T Cho; Sarojini Devi; Zhaobin Zhang; Daniel Escuin; Zhongxing Liang; Hui Mao; Daniel J Brat; Jeffrey J Olson; Jonathan W Simons; Theresa M Lavallee; Paraskevi Giannakakou; Erwin Van Meir; Hyunsuk Shim
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.
Cancer research 2006;66(24):11991-7.
2006: Fatima W Khwaja; P Svoboda; M Reed; jan pohl; Beata Pyrzynska; Erwin Van Meir
Proteomic identification of the wt-p53-regulated tumor cell secretome.
Oncogene 2006;25(58):7650-61.
2006: Vladimir E Belozerov; Erwin Van Meir
Inhibitors of hypoxia-inducible factor-1 signaling.
Current opinion in investigational drugs (London, England : 2000) 2006;7(12):1067-76.
2006: Fatima W Khwaja; J D L Nolen; Savvas Mendrinos; Melinda M Lewis; Jeffrey J Olson; jan pohl; Erwin Van Meir; James C Ritchie; Daniel J Brat
Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers.
Proteomics 2006;6(23):6277-87.
2006: Fatima W Khwaja; Jonathan S Duke-Cohan; Daniel J Brat; Erwin Van Meir
Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6331-6.
2006: Yuan Rong; Fang Hu; Ruopan Huang; Nigel Mackman; Jonathan M Horowitz; Randy L Jensen; Donald L Durden; Erwin Van Meir; Daniel J Brat
Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms.
Cancer research 2006;66(14):7067-74.
2006: Yuan Rong; Donald L Durden; Erwin Van Meir; Daniel J Brat
'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis.
Journal of neuropathology and experimental neurology 2006;65(6):529-39.
2006: Yueh-Chun Li; Ching-Cherng Tzeng; Jin H Song; Fuu-Jen Tsia; Lie-Jiau Hsieh; Shu-Ju Liao; Chang-Hai Tsai; Erwin Van Meir; Chunhai Hao; Chyi-Chyang Lin
Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2716-29.
2005: Vladimir E Belozerov; Erwin Van Meir
Hypoxia inducible factor-1: a novel target for cancer therapy.
Anti-cancer drugs 2005;16(9):901-9.
2005: Balveen Kaur; Daniel J Brat; Narra Sarojini Devi; Erwin Van Meir
Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor.
Oncogene 2005;24(22):3632-42.
2005: Dawn E Post; Hyunsuk Shim; Esra Toussaint-Smith; Erwin Van Meir
Cancer scene investigation: how a cold virus became a tumor killer.
Future oncology (London, England) 2005;1(2):247-58.
2005: Balveen Kaur; Fatima W Khwaja; Eric A Severson; Shannon L Matheny; Daniel J Brat; Erwin Van Meir
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.
Neuro-oncology 2005;7(2):134-53.
2005: Daniel J Brat; Anita Bellail; Erwin Van Meir
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.
Neuro-oncology 2005;7(2):122-33.
2005: Yuan Rong; Dawn E Post; Russell O Pieper; Donald L Durden; Erwin Van Meir; Daniel J Brat
PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.
Cancer research 2005;65(4):1406-13.
2005: Chalet Tan; Rita G de Noronha; Anthony J Roecker; Beata Pyrzynska; Fatima W Khwaja; Zhaobin Zhang; Huanchun Zhang; Quincy Teng; Ainsley Nicholson; Paraskevi Giannakakou; Wei Zhou; Jeffrey J Olson; M Manuela Pereira; Kyriacos C Nicolaou; Erwin Van Meir
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Cancer research 2005;65(2):605-12.
2005: Ainsley Nicholson; Shehre-Banoo Malik; John M Logsdon; Erwin Van Meir
Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization.
BMC evolutionary biology 2005;5():11.
2004: Dawn E Post; Narra Sarojini Devi; Zhenchao Li; Daniel J Brat; Balveen Kaur; Ainsley Nicholson; Jeffrey J Olson; Zhaobin Zhang; Erwin Van Meir
Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8603-12.
2004: Balveen Kaur; Chalet Tan; Daniel J Brat; Dawn E Post; Erwin Van Meir
Genetic and hypoxic regulation of angiogenesis in gliomas.
Journal of neuro-oncology 2004;70(2):229-43.
2004: Annalisa R Stone; William Bobo; Daniel J Brat; Narra Sarojini Devi; Erwin Van Meir; Paula M Vertino
Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.
The American journal of pathology 2004;165(4):1151-61.
2004: Pasi A Koivisto; Xiaohui Zhang; Satu-Leena Sallinen; Pauli Sallinen; Heikki Helin; Jin-Tang Dong; Erwin Van Meir; Hannu Haapasalo; Eija-Riitta Hyytinen
Absence of KLF6 gene mutations in human astrocytic tumors and cell lines.
International journal of cancer. Journal international du cancer 2004;111(4):642-3.
2004: Roland L Chu; Dawn E Post; Fadlo R Khuri; Erwin Van Meir
Use of replicating oncolytic adenoviruses in combination therapy for cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(16):5299-312.
2004: Jaren W Landen; Vincent Hau; Mingshen Wang; Thomas Davis; Brian Ciliax; Bruce H Wainer; Erwin Van Meir; Jonathan D Glass; Harish C Joshi; David R Archer
Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5187-201.
2004: L Yang; Z Cao; F Li; Dawn E Post; Erwin Van Meir; Hua Zhong; William C Wood
Tumor-specific gene expression using the survivin promoter is further increased by hypoxia.
Gene therapy 2004;11(15):1215-23.
2004: Erwin Van Meir
Opening the chamber of peer-review secrets.
Nature 2004;429(6994):803.
2004: Anita Bellail; Stephen B Hunter; Daniel J Brat; Chalet Tan; Erwin Van Meir
Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion.
The international journal of biochemistry & cell biology 2004;36(6):1046-69.
2004: Jee-Yin Ahn; Rong Rong; Todd G Kroll; Erwin Van Meir; Solomon H Snyder; Keqiang Ye
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.
The Journal of biological chemistry 2004;279(16):16441-51.
2004: Erwin Van Meir; Anita Bellail; Surasak Phuphanich
Emerging molecular therapies for brain tumors.
Seminars in oncology 2004;31(2 Suppl 4):38-46.
2004: Daniel J Brat; Erwin Van Meir
Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma.
Laboratory investigation; a journal of technical methods and pathology 2004;84(4):397-405.
2004: Dawn E Post; Giulia Fulci; E Antonio Chiocca; Erwin Van Meir
Replicative oncolytic herpes simplex viruses in combination cancer therapies.
Current gene therapy 2004;4(1):41-51.
2004: Daniel J Brat; Amilcar A Castellano-Sanchez; Stephen B Hunter; Marcia Pecot; Cynthia Cohen; Elizabeth H Hammond; Sarojini N Devi; Balveen Kaur; Erwin Van Meir
Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population.
Cancer research 2004;64(3):920-7.
2003: Charles S Cobbs; Thomas R Whisenhunt; Duane R Wesemann; Lualhati Harkins; Erwin Van Meir; Minu Samanta
Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells.
Cancer research 2003;63(24):8670-3.
2003: Ella Kim; Willy Günther; Kimio Yoshizato; Hildegard Meissner; Svenja Zapf; Rolf M Nüsing; Hirotaka Yamamoto; Erwin Van Meir; Wolfgang Deppert; Alf Giese
Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.
Oncogene 2003;22(49):7716-27.
2003: Jin H Song; doyoun song; Beata Pyrzynska; Kenneth C Petruk; Erwin Van Meir; Chunhai Hao
TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways.
Brain pathology (Zurich, Switzerland) 2003;13(4):539-53.
2003: Stephen B Hunter; Daniel J Brat; Jeffrey J Olson; Andreas von Deimling; Wei Zhou; Erwin Van Meir
Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy (Review).
International journal of oncology 2003;23(4):857-69.
2003: Dawn E Post; Fadlo R Khuri; Jonathan W Simons; Erwin Van Meir
Replicative oncolytic adenoviruses in multimodal cancer regimens.
Human gene therapy 2003;14(10):933-46.
2003: Dawn E Post; Erwin Van Meir
A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy.
Oncogene 2003;22(14):2065-72.
2003: Balveen Kaur; Daniel J Brat; Cathárine C Calkins; Erwin Van Meir
Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.
The American journal of pathology 2003;162(1):19-27.
2003: Daniel J Brat; Balveen Kaur; Erwin Van Meir
Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors.
Frontiers in bioscience : a journal and virtual library 2003;8():d100-16.
2002: Anders Bratt; William J Wilson; Boris Troyanovsky; Karin Aase; Reto Kessler; Erwin Van Meir; Lars Holmgren; Erwin G Van Meir
Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains.
Gene 2002;298(1):69-77.
2002: Michele Albertoni; Phillip H Shaw; Michimasa Nozaki; Sophie Godard; Mirna Tenan; Marie-France Hamou; Douglas W Fairlie; Samuel N Breit; Vishwas M Paralkar; Nicolas de Tribolet; Erwin Van Meir; Monika E Hegi
Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.
Oncogene 2002;21(27):4212-9.
2002: Giulia Fulci; Nobuaki Ishii; Daniela Maurici; Kim M Gernert; Pierre Hainaut; Balveen Kaur; Erwin Van Meir
Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: evidence for a precursor lesion.
Cancer research 2002;62(10):2897-905.
2002: Nicola J Mabjeesh; Dawn E Post; Margaret T Willard; Balveen Kaur; Erwin Van Meir; Jonathan W Simons; Hua Zhong
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.
Cancer research 2002;62(9):2478-82.
2002: Michael Kragh; Bjørn Quistorff; Mirna Tenan; Erwin Van Meir; Paul E.G. Kristjansen
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Cancer research 2002;62(4):1191-5.
2002: Daniel J Brat; Amilcar A Castellano-Sanchez; Balveen Kaur; Erwin Van Meir
Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation.
Advances in anatomic pathology 2002;9(1):24-36.
2001: Dawn E Post; Erwin Van Meir
Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells.
Gene therapy 2001;8(23):1801-7.
2001: J Ikeda; M Tada; N Ishii; H Saya; K Tsuchiya; K Okaichi; K Mishima; Y Sawamura; Giulia Fulci; T J Liu; Erwin Van Meir
Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis.
International journal of cancer. Journal international du cancer 2001;94(1):35-43.
2001: Florence de Fraipont; Ainsley Nicholson; Jean-Jacques Feige; Erwin Van Meir
Thrombospondins and tumor angiogenesis.
Trends in molecular medicine 2001;7(9):401-7.
2001: Guangjie Cheng; Z Cao; Xiangxi Xu; Erwin Van Meir; David J. Lambeth
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.
Gene 2001;269(1-2):131-40.
2001: M Labuhn; G Jones; E J Speel; D Maier; C Zweifel; Otmar Gratzl; Erwin Van Meir; Monika E Hegi; Adrian Merlo
Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas.
Oncogene 2001;20(9):1103-9.
2001: Daniel J Brat; Erwin Van Meir
Glomeruloid microvascular proliferation orchestrated by VPF/VEGF: a new world of angiogenesis research.
The American journal of pathology 2001;158(3):789-96.
2001: Chunhai Hao; Francesco Beguinot; Gianluigi Condorelli; Alessandra Trencia; Erwin Van Meir; V W Yong; Ian F Parney; Wilson Roa; Kenneth C Petruk
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.
Cancer research 2001;61(3):1162-70.
2001: Ugo Cavallaro; Mirna Tenan; V Castelli; A Perilli; N Maggiano; Erwin Van Meir; R Montesano; Marco Soria; MS Pepper
Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: Relevance to the regulation of angiogenesis.
Journal of cellular biochemistry 2001;82(4):619-33.
2000: Giulia Fulci; M Labuhn; D Maier; Yan Lachat; Oliver Hausmann; Monika E Hegi; Robert Janzer; Adrian Merlo; Erwin Van Meir
p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.
Oncogene 2000;19(33):3816-22.
2000: Mirna Tenan; Giulia Fulci; Michele Albertoni; Annie-Claire Diserens; Marie-France Hamou; M El Atifi-Borel; Jean-Jacques Feige; MS Pepper; Erwin Van Meir
Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.
The Journal of experimental medicine 2000;191(10):1789-98.
2000: R Kessler; Marie-France Hamou; Michele Albertoni; Nicolas de Tribolet; M Arand; Erwin Van Meir
Identification of the putative brain tumor antigen BF7/GE2 as the (de)toxifying enzyme microsomal epoxide hydrolase.
Cancer research 2000;60(5):1403-9.
1999: D Maier; G Jones; X Li; A H Schönthal; Otmar Gratzl; Erwin Van Meir; Adrian Merlo
The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.
Cancer research 1999;59(21):5479-82.
1999: N Ishii; M Tada; Marie-France Hamou; Robert Janzer; K Meagher-Villemure; O D Wiestler; N Tribolet; Erwin Van Meir
Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.
Oncogene 1999;18(43):5870-8.
1999: N Ishii; D Maier; A Merlo; M Tada; Y Sawamura; Annie-Claire Diserens; Erwin Van Meir
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain pathology (Zurich, Switzerland) 1999;9(3):469-79.
1999: M Nozaki; M Tada; H Kobayashi; C L Zhang; Y Sawamura; H Abe; N Ishii; Erwin Van Meir
Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression.
Neuro-oncology 1999;1(2):124-37.
1999: Isabelle Desbaillets; Annie-Claire Diserens; Nicolas de Tribolet; Marie-France Hamou; Erwin Van Meir
Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma.
Oncogene 1999;18(7):1447-56.
1999: Giulia Fulci; Erwin Van Meir
p53 and the CNS: tumors and developmental abnormalities.
Molecular neurobiology 1999;19(1):61-77.
1998: Michael Weller; J Rieger; C Grimmel; Erwin Van Meir; N De Tribolet; Stan Krajewski; JC Reed; A von Deimling; Johannes Dichgans
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.
International journal of cancer. Journal international du cancer 1998;79(6):640-4.
1998: Jun Ikeda; Yutaka Sawamura; Erwin Van Meir
Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome?
British journal of neurosurgery 1998;12(6):576-8.
1998: Giulia Fulci; N Ishii; Erwin Van Meir
p53 and brain tumors: from gene mutations to gene therapy.
Brain pathology (Zurich, Switzerland) 1998;8(4):599-613.
1998: Jun-ichi Hamada; Y Sawamura; Erwin Van Meir
CD44 expression and growth factors.
Frontiers in bioscience : a journal and virtual library 1998;3():d657-64.
1998: D Maier; Z Zhang; E Taylor; Marie-France Hamou; Otmar Gratzl; Erwin Van Meir; R J Scott; Adrian Merlo
Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.
Oncogene 1998;16(25):3331-5.
1998: N Ishii; Y Sawamura; M Tada; D M Daub; Robert Janzer; M Meagher-Villemure; Nicolas de Tribolet; Erwin Van Meir
Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay.
International journal of cancer. Journal international du cancer 1998;76(6):797-800.
1998: Yasuo Tohma; C Gratas; Erwin Van Meir; Isabelle Desbaillets; Mirna Tenan; Osamu Tachibana; Paul Kleihues; Hiroko Ohgaki
Necrogenesis and Fas/APO-1 (CD95) expression in primary (de novo) and secondary glioblastomas.
Journal of neuropathology and experimental neurology 1998;57(3):239-45.
1998: Michele Albertoni; D M Daub; Karen C Arden; Carrie Viars; C Powell; Erwin Van Meir
Genetic instability leads to loss of both p53 alleles in a human glioblastoma.
Oncogene 1998;16(3):321-6.
1998: Erwin Van Meir
"Turcot's syndrome": phenotype of brain tumors, survival and mode of inheritance.
International journal of cancer. Journal international du cancer 1998;75(1):162-4.
1997: Isabelle Desbaillets; Annie-Claire Diserens; N Tribolet; Marie-France Hamou; Erwin Van Meir
Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis.
The Journal of experimental medicine 1997;186(8):1201-12.
1997: D Maier; D Comparone; E Taylor; Z Zhang; Otmar Gratzl; Erwin Van Meir; R J Scott; Adrian Merlo
New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26.
Oncogene 1997;15(8):997-1000.
1997: C Gratas; Yasuo Tohma; Erwin Van Meir; M Klein; Mirna Tenan; N Ishii; Osamu Tachibana; Paul Kleihues; Hiroko Ohgaki
Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors.
Brain pathology (Zurich, Switzerland) 1997;7(3):863-9.
1997: F Paraf; Serge Jothy; Erwin Van Meir
Brain tumor-polyposis syndrome: two genetic diseases?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(7):2744-58.
1997: Erwin Van Meir
Identification of nude mice in tumorigenicity assays.
International journal of cancer. Journal international du cancer 1997;71(2):310.
1997: Philippe Saas; Paul R Walker; M Hahne; Anne-Lise Quiquerez; Valerie Schnuriger; Gaëlle Perrin; L French; Erwin Van Meir; N de Tribolet; J Tschopp; Pierre-Yves Dietrich
Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?
The Journal of clinical investigation 1997;99(6):1173-8.
1996: Erwin Van Meir
Hypoxia-mediated selection of cells with diminished apoptotic potential to solid tumours.
Neurosurgery 1996;39(4):878-9.
1995: G H Baltuch; Nicolas de Tribolet; Erwin Van Meir
Expression of the CD44 adhesion molecule in tumours of the central and peripheral nervous system.
Journal of neuro-oncology 1995;26(3):191-8.
1995: Erwin Van Meir; N de Tribolet
Microsatellite instability in human brain tumors.
Neurosurgery 1995;37(6):1231-2.
1995: Erwin Van Meir
Cytokines and tumors of the central nervous system.
Glia 1995;15(3):264-88.
1995: Erwin Van Meir; K Roemer; Annie-Claire Diserens; T Kikuchi; Sandra Rempel; M Haas; H-J Su Huang; T Friedmann; N de Tribolet; Webster K Cavenee
Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1008-12.
1994: Erwin Van Meir; Peter J Polverini; V R Chazin; H J Su Huang; N de Tribolet; Webster K Cavenee
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells.
Nature genetics 1994;8(2):171-6.
1994: Isabelle Desbaillets; M Tada; Nicolas de Tribolet; Annie-Claire Diserens; Marie-France Hamou; Erwin Van Meir
Human astrocytomas and glioblastomas express monocyte chemoattractant protein-1 (MCP-1) in vivo and in vitro.
International journal of cancer. Journal international du cancer 1994;58(2):240-7.
1994: J Liu; H Li; N de Tribolet; R Jaufeerally; Marie-France Hamou; Erwin Van Meir
IL-6 stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B-cell hybridoma 7TD1.
Cellular immunology 1994;155(2):428-35.
1994: Erwin Van Meir; T Kikuchi; M Tada; H Li; Annie-Claire Diserens; B E Wojcik; H-J Su Huang; T Friedmann; Nicolas de Tribolet; Webster K Cavenee
Analysis of the p53 gene and its expression in human glioblastoma cells.
Cancer research 1994;54(3):649-52.
1994: T Kikuchi; Annie-Claire Diserens; Marie-France Hamou; N de Tribolet; Erwin Van Meir
[Overexpression of p53 protein in gliomas].
No shinkei geka. Neurological surgery 1994;22(2):125-9.
1993: H Li; Marie-France Hamou; Nicolas de Tribolet; R Jaufeerally; Martin Hofmann-Apitius; Annie-Claire Diserens; Erwin Van Meir
Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas.
Cancer research 1993;53(22):5345-9.
1993: Kenmei Takaichi; Daniel F Balkovetz; Erwin Van Meir; David G Warnock
Cytosolic pH sensitivity of an expressed human NHE-1 Na(+)-H+ exchanger.
The American journal of physiology 1993;264(4 Pt 1):C944-50.
1993: M Tada; K Suzuki; Y Yamakawa; Yutaka Sawamura; S Sakuma; Hiroshi Abe; Erwin Van Meir; N de Tribolet
Human glioblastoma cells produce 77 amino acid interleukin-8 (IL-8(77)).
Journal of neuro-oncology 1993;16(1):25-34.
1993: T Kikuchi; Sandra Rempel; Hans Peter Rutz; Nicolas de Tribolet; L Mulligan; Webster K Cavenee; Serge Jothy; L Leduy; Erwin Van Meir
Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene.
Cancer research 1993;53(5):957-61.
1992: Erwin Van Meir; M Ceska; F Effenberger; A Walz; E Grouzmann; I Desbaillets; K Frei; A Fontana; N de Tribolet
Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system.
Cancer research 1992;52(16):4297-305.
1992: Annette G Beck-Sickinger; Eric Grouzmann; E Hoffmann; W Gaida; Erwin Van Meir; B Waeber; G Jung
A novel cyclic analog of neuropeptide Y specific for the Y2 receptor.
European journal of biochemistry / FEBS 1992;206(3):957-64.
1992: Karl Frei; D Piani; Ursula Malipiero; Erwin Van Meir; N de Tribolet; Adriano Fontana
Granulocyte-macrophage colony-stimulating factor (GM-CSF) production by glioblastoma cells. Despite the presence of inducing signals GM-CSF is not expressed in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3140-6.
1992: M C Kuppner; Erwin Van Meir; T Gauthier; Marie-France Hamou; Nicolas de Tribolet
Differential expression of the CD44 molecule in human brain tumours.
International journal of cancer. Journal international du cancer 1992;50(4):572-7.
1990: Erwin Van Meir; Y Sawamura; Annie-Claire Diserens; Marie-France Hamou; N de Tribolet
Human glioblastoma cells release interleukin 6 in vivo and in vitro.
Cancer research 1990;50(20):6683-8.
1990: M C Kuppner; Erwin Van Meir; Marie-France Hamou; Nicolas de Tribolet
Cytokine regulation of intercellular adhesion molecule-1 (ICAM-1) expression on human glioblastoma cells.
Clinical and experimental immunology 1990;81(1):142-8.
1988: Erwin Van Meir; Riccardo Wittek
Fine structure of the vaccinia virus gene encoding the precursor of the major core protein 4 a.
Archives of virology 1988;102(1-2):19-27.
1987: C Bertholet; Erwin Van Meir; B ten Heggeler-Bordier; Riccardo Wittek
Vaccinia virus produces late mRNAs by discontinuous synthesis.
Cell 1987;50(2):153-62.
1986: C Bertholet; P Stocco; Erwin Van Meir; Riccardo Wittek
Functional analysis of the 5' flanking sequence of a vaccinia virus late gene.
The EMBO journal 1986;5(8):1951-7.
1984: E Back; Erwin Van Meir; Fritz Müller; D Schaller; H Neuhaus; P Aeby; Heinz Tobler
Intervening sequences in the ribosomal RNA genes of Ascaris lumbricoides: DNA sequences at junctions and genomic organization.
The EMBO journal 1984;3(11):2523-9.