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Gerrit Alink

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Sourav Bhattacharjee; Rhett J Clark; Mark J Fink; Susan M Kauzlarich; Antonius T M Marcelis; Brian S Mitchell; Tapas K Purkait; Sarah Regli; Ivonne M C M Rietjens; Amber Shukaliak; Mani P Singh; Jonathan G C Veinot; Zejing Xu; Gerrit M Alink; Tonya M Atkins; Han Zuilhof
Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges.
Sourav Bhattacharjee; Dmitry Ershov; Jasper van der Gucht; Ivonne M C M Rietjens; Han Zuilhof; Gerrit M Alink; Antonius T M Marcelis
Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles.
E J M Penders; S G P Rotteveel; Albertus Spenkelink; W Hoogenboezem; J L Maas; Gerrit M Alink
Genotoxic effects in the Eastern mudminnow (Umbra pygmaea) after prolonged exposure to River Rhine water, as assessed by use of the in vivo SCE and Comet assays.

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2013: Sourav Bhattacharjee; Rhett J Clark; Mark J Fink; Susan M Kauzlarich; Antonius T M Marcelis; Brian S Mitchell; Tapas K Purkait; Sarah Regli; Ivonne M C M Rietjens; Amber Shukaliak; Mani P Singh; Jonathan G C Veinot; Zejing Xu; Gerrit M Alink; Tonya M Atkins; Han Zuilhof
Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges.
Nanoscale 2013;5(11):4870-83.
2013: Sourav Bhattacharjee; Dmitry Ershov; Jasper van der Gucht; Ivonne M C M Rietjens; Han Zuilhof; Gerrit M Alink; Antonius T M Marcelis
Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles.
Nanotoxicology 2013;7(1):71-84.
2012: E J M Penders; S G P Rotteveel; Albertus Spenkelink; W Hoogenboezem; J L Maas; Gerrit M Alink
Genotoxic effects in the Eastern mudminnow (Umbra pygmaea) after prolonged exposure to River Rhine water, as assessed by use of the in vivo SCE and Comet assays.
Environmental and molecular mutagenesis 2012;53(4):304-10.
2012: Kunal Bhattacharya; Jens Boertz; Hugh James Byrne; Eik Hoffmann; Thomas A J Kuhlbusch; Eva-Maria Prantl; Qamar Rahman; Roel F P Schins; Christof Schulz; Hartmut Wiggers; Gerrit M Alink; Elke Dopp
Comparison of micro- and nanoscale Fe⁺³-containing (Hematite) particles for their toxicological properties in human lung cells in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(1):173-82.
2012: Sourav Bhattacharjee; Dmitry Ershov; Kleanthis Fytianos; Antonius T M Marcelis; Ivonne M C M Rietjens; Jasper van der Gucht; Gerrit M Alink; Han Zuilhof
Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics.
Particle and fibre toxicology 2012;9():11.
2010: Sourav Bhattacharjee; Laura H J de Haan; Nynke M Evers; Xue Jiang; Antonius T M Marcelis; Han Zuilhof; Ivonne M C M Rietjens; Gerrit M Alink
Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells.
Particle and fibre toxicology 2010;7():25.
2009: Vincent A van Beelen; Bert Spenkelink; Hans Mooibroek; Lolke Sijtsma; Dirk Bosch; Ivonne M C M Rietjens; Gerrit M Alink
An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(2):316-20.
2008: Maaike E Schutte; Gerrit M Alink; Andreas P Freidig; Bert Spenkelink; Judith C H Vaessen; Johannes J M van de Sandt; John P Groten; Ivonne M C M Rietjens
Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(11):3422-8.
2008: Ashwin A Dihal; Hester van der Woude; Peter J M Hendriksen; Halima Charif; Lennard Dekker; Linda Ijsselstijn; Vincent C J de Boer; Gerrit M Alink; Peter C Burgers; Ivonne M C M Rietjens; Ruud A Woutersen; Rob H Stierum
Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis.
Proteomics 2008;8(1):45-61.
2007: Gerrit M Alink; J T K Quik; E J M Penders; Albertus Spenkelink; S G P Rotteveel; J L Maas; W Hoogenboezem
Genotoxic effects in the Eastern mudminnow (Umbra pygmaea L.) after exposure to Rhine water, as assessed by use of the SCE and Comet assays: a comparison between 1978 and 2005.
Mutation research 2007;631(2):93-100.
2007: Vincent A van Beelen; Johannes Roeleveld; Hans Mooibroek; Lolke Sijtsma; Raoul J Bino; Dirk Bosch; Ivonne M C M Rietjens; Gerrit M Alink
A comparative study on the effect of algal and fish oil on viability and cell proliferation of Caco-2 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(5):716-24.
2006: Maaike E Schutte; Andreas P Freidig; Johannes J M van de Sandt; Gerrit M Alink; Ivonne M C M Rietjens; John P Groten
An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers.
Toxicology and applied pharmacology 2006;217(2):204-15.
2006: Ashwin A Dihal; Vincent C J de Boer; Hester van der Woude; Chantal Tilburgs; Joost P Bruijntjes; Gerrit M Alink; Ivonne M C M Rietjens; Ruud A Woutersen; Rob H Stierum
Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats.
The Journal of nutrition 2006;136(11):2862-7.
2006: Dominik Kisztelinski; Gerrit M Alink; Ivonne M C M Rietjens; Stanislaw Bielecki; Johannes Tramper; Dirk E Martens
Application of a continuous bioreactor cascade to study the effect of linoleic acid on hybridoma cell physiology.
Biotechnology and bioengineering 2006;95(3):370-83.
2006: Vincent A van Beelen; Jac M M J G Aarts; Astrid Reus; Hans Mooibroek; Lolke Sijtsma; Dirk Bosch; Ivonne M C M Rietjens; Gerrit M Alink
Differential induction of electrophile-responsive element-regulated genes by n-3 and n-6 polyunsaturated fatty acids.
FEBS letters 2006;580(19):4587-90.
2006: Ivonne M C M Rietjens; Gerrit M Alink
Future of toxicology--low-dose toxicology and risk--benefit analysis.
Chemical research in toxicology 2006;19(8):977-81.
2006: Laura H J De Haan; Gerda K Pot; Jac M M J G Aarts; Ivonne M C M Rietjens; Gerrit M Alink
In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(5):594-600.
2006: Hester van der Woude; Marelle G Boersma; Gerrit M Alink; Jacques Vervoort; Ivonne M C M Rietjens
Consequences of quercetin methylation for its covalent glutathione and DNA adduct formation.
Chemico-biological interactions 2006;160(3):193-203.
2006: Maaike E Schutte; Johannes J M van de Sandt; Gerrit M Alink; John P Groten; Ivonne M C M Rietjens
Myricetin stimulates the absorption of the pro-carcinogen PhIP.
Cancer letters 2006;231(1):36-42.
2006: Suzanne M F Jeurissen; Jan J P Bogaards; Marelle G Boersma; Judith P F ter Horst; Hanem M Awad; Yiannis C Fiamegos; Teris A van Beek; Gerrit M Alink; Ernst J R Sudhölter; Nicole H P Cnubben; Ivonne M C M Rietjens
Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.
Chemical research in toxicology 2006;19(1):111-6.
2005: Hester van der Woude; Gerrit M Alink; Bart E J van Rossum; Kristina Walle; Harry van Steeg; Thomas Walle; Ivonne M C M Rietjens
Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity.
Chemical research in toxicology 2005;18(12):1907-16.
2005: Hester van der Woude; Gerrit M Alink; Ivonne M C M Rietjens
The definition of hormesis and its implications for in vitro to in vivo extrapolation and risk assessment.
Critical reviews in toxicology 2005;35(6):603-7.
2005: Vincent C J de Boer; Ashwin A Dihal; Hester van der Woude; Ilja C W Arts; Siegfried Wolffram; Gerrit M Alink; Ivonne M C M Rietjens; Jaap Keijer; Peter C H Hollman
Tissue distribution of quercetin in rats and pigs.
The Journal of nutrition 2005;135(7):1718-25.
2005: Ivonne M C M Rietjens; Marelle G Boersma; Hester van der Woude; Suzanne M F Jeurissen; Maaike E Schutte; Gerrit M Alink
Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk.
Mutation research 2005;574(1-2):124-38.
2005: Ivonne M C M Rietjens; Martijn J Martena; Marelle G Boersma; Wim Spiegelenberg; Gerrit M Alink
Molecular mechanisms of toxicity of important food-borne phytotoxins.
Molecular nutrition & food research 2005;49(2):131-58.
2005: Eric H Vis; Gert-Jan Geerse; Eline Klaassens; Martinus A J S van Boekel; Gerrit M Alink
Possible mechanisms behind the differential effects of soy protein and casein feedings on colon cancer biomarkers in the rat.
Nutrition and cancer 2005;51(1):37-44.
2004: Suzanne M F Jeurissen; Jan J P Bogaards; Hanem M Awad; Marelle G Boersma; Walter Brand; Yiannis C Fiamegos; Teris A van Beek; Gerrit M Alink; Ernst J R Sudhölter; Nicole H P Cnubben; Ivonne M C M Rietjens
Human cytochrome p450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1'-hydroxysafrole.
Chemical research in toxicology 2004;17(9):1245-50.
2004: Sara J Boeke; Marelle G Boersma; Gerrit M Alink; Joop J A Van Loon; Arnold van Huis; Marcel Dicke; Ivonne M C M Rietjens
Safety evaluation of neem (Azadirachta indica) derived pesticides.
Journal of ethnopharmacology 2004;94(1):25-41.
2004: Harald J J Moonen; Y E M Dommels; M van Zwam; Marcel H M van Herwijnen; Jos C S Kleinjans; Gerrit M Alink; Theo M C M De Kok
Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells.
Molecular carcinogenesis 2004;40(3):180-8.
2003: Yvonne E M Dommels; Suzanne Heemskerk; Hans van den Berg; Gerrit M Alink; Peter J van Bladeren; Ben van Ommen
Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(12):1739-47.
2003: Hester van der Woude; Anna Gliszczyńska-Swigło; Karin Struijs; Astrid Smeets; Gerrit M Alink; Ivonne M C M Rietjens
Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans.
Cancer letters 2003;200(1):41-7.
2003: Yvonne E M Dommels; Merel M G Haring; Nynke G M Keestra; Gerrit M Alink; Peter J van Bladeren; Ben van Ommen
The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE(2) synthesis and cytotoxicity in human colorectal carcinoma cell lines.
Carcinogenesis 2003;24(3):385-92.
2002: Magda M W Ulrich; Gerrit M Alink; Premkumari Kumarathasan; Renaud Vincent; john boere; Flemming R Cassee
Health effects and time course of particulate matter on the cardiopulmonary system in rats with lung inflammation.
Journal of toxicology and environmental health. Part A 2002;65(20):1571-95.
2002: Ivonne M C M Rietjens; Bert Spenkelink; Jelmer J van Zanden; Laura de Haan; Hester van der Woude; Gerrit M Alink; Hanem M Awad; Marelle G Boersma; Nicole H P Cnubben; Jan H Koeman
The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids.
Environmental toxicology and pharmacology 2002;11(3-4):321-33.
2002: Yvonne E M Dommels; Peter J van Bladeren; Gerrit M Alink; Ben van Ommen
Dietary n-6 and n-3 polyunsaturated fatty acids and colorectal carcinogenesis: results from cultured colon cells, animal models and human studies.
Environmental toxicology and pharmacology 2002;11(3-4):297-308.
2002: Yvonne E M Dommels; Gerrit M Alink; J P H Linssen; Ben van Ommen
Effects of n-6 and n-3 polyunsaturated fatty acids on gap junctional intercellular communication during spontaneous differentiation of the human colon adenocarcinoma cell line Caco-2.
Nutrition and cancer 2002;42(1):125-30.
2000: Carline M J Brands; Gerrit M Alink; Martinus A J S van Boekel; Wim M F Jongen
Mutagenicity of heated sugar-casein systems: effect of the Maillard reaction.
Journal of agricultural and food chemistry 2000;48(6):2271-5.
1998: JM Rijnkels; A C van der Reijden; D B Delsing; Gerrit M Alink
Effects of vegetables-fruit extracts and indole-3-carbinol on stearic acid-modulated intercellular communication and cytochrome P450-IA activity.
Environmental toxicology and pharmacology 1998;6(2):103-9.
1998: Henk J van Kranen; P W van Iersel; JM Rijnkels; D B Beems; Gerrit M Alink; Coen F van Kreijl
Effects of dietary fat and a vegetable-fruit mixture on the development of intestinal neoplasia in the ApcMin mouse.
Carcinogenesis 1998;19(9):1597-601.
1998: Gerrit M Alink; M Sjögren; Rob P Bos; G Doekes; H Kromhout; P T J Scheepers
Effect of airborne particles from selected indoor and outdoor environments on gap-junctional intercellular communication.
Toxicology letters 1998;96-97():209-13.
1998: JM Rijnkels; Gerrit M Alink
Effects of a vegetables-fruit mixture on liver and colonic 1,2-dimethylhydrazine-metabolizing enzyme activities in rats fed low- or high-fat diets.
Cancer letters 1998;128(2):171-5.
1998: Peter A Steerenberg; Johan Garssen; PM Dortant; Peter C H Hollman; Gerrit M Alink; M Dekker; bas bueno-de-mesquita; Henk Van Loveren
Protection of UV-induced suppression of skin contact hypersensitivity: a common feature of flavonoids after oral administration?
Photochemistry and photobiology 1998;67(4):456-61.
1998: JM Rijnkels; VM Hollanders; Ruud A Woutersen; JH Koeman; Gerrit M Alink
Absence of an inhibitory effect of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis in rats fed low- or high-fat diets.
Nutrition and cancer 1998;30(2):124-9.
1997: JM Rijnkels; VM Hollanders; Ruud A Woutersen; JH Koeman; Gerrit M Alink
Interaction of dietary fat and of a vegetables/fruit mixture on 1,2-dimethylhydrazine- or N-methyl-N'-nitro-N-nitrosoguanidine-induced colorectal cancer in rats.
Cancer letters 1997;114(1-2):297-8.
1997: Gerrit M Alink; JM Rijnkels; H A Kuiper; VM Hollanders; Ruud A Woutersen
Carcinogenicity testing of complete human diets in rats.
Cancer letters 1997;114(1-2):271-4.
1997: Martinus A J S van Boekel; A R Goeptar; Gerrit M Alink
Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay.
Cancer letters 1997;114(1-2):85-7.
1997: JM Rijnkels; VM Hollanders; Ruud A Woutersen; JH Koeman; Gerrit M Alink
Modulation of dietary fat-enhanced colorectal carcinogenesis in N-methyl-N'-nitro-N-nitrosoguanidine-treated rats by a vegetables-fruit mixture.
Nutrition and cancer 1997;29(1):90-5.
1997: JM Rijnkels; VM Hollanders; Ruud A Woutersen; JH Koeman; Gerrit M Alink
Interaction of dietary fat with a vegetables-fruit mixture on 1,2-dimethylhydrazine-induced colorectal cancer in rats.
Nutrition and cancer 1997;27(3):261-6.
1996: G A Heussen; J H van den Berg; H C Dreef-van der Meulen; Gerrit M Alink
Carcinogenicity study of outdoor airborne particulate matter in newborn male NMRI mice.
Toxicology letters 1996;88(1-3):23-8.
1994: I E Bosselaers; P W Caessens; Martinus A J S van Boekel; Gerrit M Alink
Differential effects of milk proteins, BSA and soy protein on 4NQO- or MNNG-induced SCEs in V79 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(10):905-9.
1994: G A Heussen; Gerrit M Alink
Inhibition of gap-junctional intercellular communication by outdoor and indoor airborne particulate matter.
Toxicology letters 1994;72(1-3):87-94.
1994: Gerrit M Alink; Abraham Brouwer; G A Heussen
Effects of outdoor and indoor airborne particulate matter on thyroid hormone and vitamin A metabolism.
Toxicology letters 1994;72(1-3):73-81.
1994: G A Heussen; H G Bouman; R Roggeband; RA Baan; Gerrit M Alink
32P-postlabelling analysis of DNA adducts in white blood cells of humans exposed to residential wood combustion particulate matter.
Environmental and molecular mutagenesis 1994;23(2):121-7.
1993: Martinus A J S van Boekel; C N Weerens; A Holstra; C E Scheidtweiler; Gerrit M Alink
Antimutagenic effects of casein and its digestion products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(10):731-7.
1993: G A Heussen; G J Schefferlie; M J Talsma; H van Til; M J Dohmen; Abraham Brouwer; Gerrit M Alink
Effects on thyroid hormone metabolism and depletion of lung vitamin A in rats by airborne particulate matter.
Journal of toxicology and environmental health 1993;38(4):419-34.
1993: Gerrit M Alink; H A Kuiper; VM Hollanders; JH Koeman
Effect of heat processing and of vegetables and fruit in human diets on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Carcinogenesis 1993;14(3):519-24.
1992: G A Heussen; Gerrit M Alink
Inhibition of gap-junctional intercellular communication by TPA and airborne particulate matter in primary cultures of rat alveolar type II cells.
Carcinogenesis 1992;13(4):719-22.
1990: R M Zwijsen; E M van Kleef; Gerrit M Alink
A comparative study on the metabolic activation of 3,4-benzo[a]pyrene to mutagens by aorta smooth muscle cells of rat and rabbit.
Mutation research 1990;230(1):111-7.
1990: G A Heussen; J G Post; Gerrit M Alink
Genotoxicity of benzo[a]pyrene, 2-nitrofluorene and airborne particulates in the DNA-repair host-mediated assay.
Mutation research 1990;241(1):83-93.
1989: Gerrit M Alink; H A Kuiper; R B Beems; JH Koeman
A study on the carcinogenicity of human diets in rats: the influence of heating and the addition of vegetables and fruit.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(7):427-36.
1989: J J van Houdt; L H de Haan; Gerrit M Alink
The release of mutagens from airborne particles in the presence of physiological fluids.
Mutation research 1989;222(3):155-60.
1988: Gerrit M Alink; P L Reijven; S R Sijtsma; Wim M F Jongen; R J Topp; H A Kuiper; JH Koeman
Effects of human diets on biotransformation enzyme activity and metabolic activation of carcinogens in rat liver.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1988;26(11-12):883-91.
1988: Gerrit M Alink; Mark G Knize; N H Shen; S P Hesse; J S Felton
Mutagenicity of food pellets from human diets in The Netherlands.
Mutation research 1988;206(3):387-93.
1988: J J van Houdt; P W Coenen; Gerrit M Alink; J S Boleij; JH Koeman
Organ specific metabolic activation of five extracts of indoor and outdoor particulate matter.
Archives of toxicology 1988;61(3):213-7.
1987: R M Vos; Ivonne M C M Rietjens; Gerrit M Alink; Peter J van Bladeren
Methyl linoleate ozonide: a substrate for rat glutathione S-transferases.
European journal of drug metabolism and pharmacokinetics 1987;12(4):275-7.
1986: J J van Houdt; C M Daenen; J S Boleij; Gerrit M Alink
Contribution of wood stoves and fire places to mutagenic activity of airborne particulate matter inside homes.
Mutation research 1986;171(2-3):91-8.
1985: Ivonne M C M Rietjens; Gerrit M Alink; R M Vos
The role of glutathione and changes in thiol homeostasis in cultured lung cells exposed to ozone.
Toxicology 1985;35(3):207-17.
1984: J J van Houdt; Wim M F Jongen; Gerrit M Alink; J S Boleij
Mutagenic activity of airborne particles inside and outside homes.
Environmental mutagenesis 1984;6(6):861-9.
1983: Gerrit M Alink; H A Smit; J J van Houdt; J R Kolkman; J S Boleij
Mutagenic activity of airborne particulates at non-industrial locations.
Mutation research 1983;116(1):21-34.
1982: Wim M F Jongen; Gerrit M Alink
Enzyme-mediated mutagenicity in Salmonella typhimurium of contaminants of synthetic indigo products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1982;20(6):917-20.
1982: Wim M F Jongen; E G Harmsen; Gerrit M Alink; JH Koeman
The effect of glutathione conjugation and microsomal oxidation on the mutagenicity of dichloromethane in S. typhimurium.
Mutation research 1982;95(2-3):183-9.
1982: J C van der Hoeven; I M Bruggeman; Gerrit M Alink; JH Koeman
The killifish Nothobranchius rachowi, a new animal in genetic toxicology.
Mutation research 1982;97(1):35-42.
1981: Wim M F Jongen; P H Lohman; M J Kottenhagen; Gerrit M Alink; F Berends; JH Koeman
Mutagenicity testing of dichloromethane in short-term mammalian tests systems.
Mutation research 1981;81(2):203-13.