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Ester Carballo-Jane

Research Profile

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Chemicals & Drugs

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Publications

TOP 3
Alison M Strack; Anil Thankappan; Xinchun Tong; Sheng-Ping Wang; M Gerard Waters; Michael Wolff; John Woods; T J Wu; Jiyan Xue; Emanuel Zycband; Charlotte Burton; Ester Carballo-Jane; Ching H Chang; Jing Chen; Brian Hubbard; Douglas Kawka; Silvi Luell; Michele Mariano; Lesley Ann McNamara; John Menke; Gary O'Neill; Xiaoli Ping; Olga Price; Richard Raubertas; Carl P Sparrow; Ayesha Sitlani
Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.
Zhu Chen; Suzanne Eveland; Timothy S Fisher; Betsy Frantz-Wattley; Karen Gagen; Brian K Hubbard; Marina Ichetovkin; Douglas G Johns; Silvi Luell; Roger Meurer; Edward A O'Neill; Carl P Sparrow; Alison M Strack; Sheng-Ping Wang; Samuel D Wright; Ester Carballo-Jane
Reconstituted HDL elicits marked changes in plasma lipids following single-dose injection in C57Bl/6 mice.
P Douglas Boatman; Ester Carballo-Jane; Luzelena Caro; Ruoping Chen; Martin C Cherrier; Steven L Colletti; Daniel T Connolly; Josee Cote; Milton Hammond; Benjamin R Johnson; Jae-Kyu Jung; Michelle Kasem; Jens Knudsen; Eseng Lai; Brett Lauring; Wen-Lin Luo; Carleton R Sage; Thomas O Schrader; Graeme Semple; Philip J Skinner; Andrew K P Taggart; James R Tata; John Wagner; M Gerard Waters; Peter J Webb; Jerry Xu; Jeremy G Richman
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.

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All Publications

2013: Alison M Strack; Anil Thankappan; Xinchun Tong; Sheng-Ping Wang; M Gerard Waters; Michael Wolff; John Woods; T J Wu; Jiyan Xue; Emanuel Zycband; Charlotte Burton; Ester Carballo-Jane; Ching H Chang; Jing Chen; Brian Hubbard; Douglas Kawka; Silvi Luell; Michele Mariano; Lesley Ann McNamara; John Menke; Gary O'Neill; Xiaoli Ping; Olga Price; Richard Raubertas; Carl P Sparrow; Ayesha Sitlani
Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.
Journal of lipid research 2013;54(1):177-88.
2012: Zhu Chen; Suzanne Eveland; Timothy S Fisher; Betsy Frantz-Wattley; Karen Gagen; Brian K Hubbard; Marina Ichetovkin; Douglas G Johns; Silvi Luell; Roger Meurer; Edward A O'Neill; Carl P Sparrow; Alison M Strack; Sheng-Ping Wang; Samuel D Wright; Ester Carballo-Jane
Reconstituted HDL elicits marked changes in plasma lipids following single-dose injection in C57Bl/6 mice.
Journal of cardiovascular pharmacology and therapeutics 2012;17(3):315-23.
2012: P Douglas Boatman; Ester Carballo-Jane; Luzelena Caro; Ruoping Chen; Martin C Cherrier; Steven L Colletti; Daniel T Connolly; Josee Cote; Milton Hammond; Benjamin R Johnson; Jae-Kyu Jung; Michelle Kasem; Jens Knudsen; Eseng Lai; Brett Lauring; Wen-Lin Luo; Carleton R Sage; Thomas O Schrader; Graeme Semple; Philip J Skinner; Andrew K P Taggart; James R Tata; John Wagner; M Gerard Waters; Peter J Webb; Jerry Xu; Jeremy G Richman
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
Journal of medicinal chemistry 2012;55(8):3644-66.
2010: Ester Carballo-Jane; Zhu Chen; Edward O'Neill; Jun Wang; Charlotte Burton; Ching H Chang; Xun Chen; Suzanne Eveland; Betsy Frantz-Wattley; Karen Gagen; Brian Hubbard; Marina Ichetovkin; Silvi Luell; Roger Meurer; Xuelei Song; Alison Strack; Annunziata Langella; Simona Cianetti; Francesca Rech; Elena Capitò; Simone Bufali; Maria Veneziano; Maria Verdirame; Fabio Bonelli; Edith Monteagudo; Antonello Pessi; Raffaele Ingenito; Elisabetta Bianchi
ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose.
Bioorganic & medicinal chemistry 2010;18(24):8669-78.
2010: Daniël Blom; Ting-Ting Yamin; Marie-France Champy; Mohammed Selloum; Elodie Bedu; Ester Carballo-Jane; Lynn Gerckens; Silvi Luell; Roger Meurer; Jayne Chin; John Mudgett; Oscar Puig
Altered lipoprotein metabolism in P2Y(13) knockout mice.
Biochimica et biophysica acta 2010;1801(12):1349-60.
2010: Jason E Imbriglio; Sookhee Chang; Rui Liang; Subharekha Raghavan; Darby Schmidt; Abby Smenton; Scott Tria; Thomas O Schrader; Jae-Kyu Jung; Craig Esser; Tom Holt; Michael S Wolff; Andrew K P Taggart; Kang Cheng; Ester Carballo-Jane; M Gerard Waters; James R Tata; Steven L Colletti
GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.
Bioorganic & medicinal chemistry letters 2010;20(15):4472-4.
2010: Darby Schmidt; Abigail Smenton; Subharekha Raghavan; Hong Shen; Fa-Xiang Ding; Ester Carballo-Jane; Silvi Luell; Tanya Ciecko; Tom Holt; Michael Wolff; Andrew K P Taggart; Larissa Wilsie; Mihajlo Krsmanovic; Ning Ren; Daniel Blom; Kang Cheng; Peggy E McCann; M Gerard Waters; James Tata; Steven Colletti
Anthranilic acid replacements in a niacin receptor agonist.
Bioorganic & medicinal chemistry letters 2010;20(11):3426-30.
2010: P Douglas Boatman; Thomas O Schrader; Michelle Kasem; Benjamin R Johnson; Philip J Skinner; Jae-Kyu Jung; Jerry Xu; Martin C Cherrier; Peter J Webb; Graeme Semple; Carleton R Sage; Jens Knudsen; Ruoping Chen; Andrew K P Taggart; Ester Carballo-Jane; Jeremy G Richman
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).
Bioorganic & medicinal chemistry letters 2010;20(9):2797-800.
2010: Hong C Shen; Fa-Xiang Ding; Subharekha Raghavan; Qiaolin Deng; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom G Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Journal of medicinal chemistry 2010;53(6):2666-70.
2009: Darby Schmidt; Abigail Smenton; Subharekha Raghavan; Ester Carballo-Jane; Silvi Lubell; Tanya Ciecko; Tom Holt; Michael Wolff; Andrew K P Taggart; Larissa Wilsie; Mihajlo Krsmanovic; Ning Ren; Daniel Blom; Kang Cheng; Peggy E McCann; M Gerard Waters; James R Tata; Steven Colletti
Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia.
Bioorganic & medicinal chemistry letters 2009;19(16):4768-72.
2009: Songnian Lin; Matthew Lombardo; Sunita Malkani; Jeffrey J Hale; Sander G Mills; Kevin Chapman; James E Thompson; Wen Xiao Zhang; Ruixiu Wang; Rose M Cubbon; Edward A O'Neill; Silvi Luell; Ester Carballo-Jane; Lihu Yang
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Bioorganic & medicinal chemistry letters 2009;19(12):3238-42.
2009: Hong Shen; Fa-Xiang Ding; Qiaolin Deng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ester Carballo-Jane; Ning Ren; Tian-Quan Cai; Tsuei-Ju Wu; Kenneth K Wu; Kang Cheng; Qing Chen; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Journal of medicinal chemistry 2009;52(8):2587-602.
2009: Jason E Imbriglio; Sookhee Chang; Rui Liang; Subharekha Raghavan; Darby Schmidt; Abby Smenton; Scott Tria; Thomas O Schrader; Jae-Kyu Jung; Craig Esser; Andrew K P Taggart; Kang Cheng; Ester Carballo-Jane; M Gerard Waters; James R Tata; Steven L Colletti
GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.
Bioorganic & medicinal chemistry letters 2009;19(8):2121-4.
2008: Qiaolin Deng; Jessica L Frie; Daria M Marley; Richard T Beresis; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Kang Cheng; Ester Carballo-Jane; Junying Wang; Xinchun Tong; M Gerard Waters; James R Tata; Steven L Colletti
Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.
Bioorganic & medicinal chemistry letters 2008;18(18):4963-7.
2008: Graeme Semple; Philip J Skinner; Tawfik Gharbaoui; Young-Jun Shin; Jae-Kyu Jung; Martin C Cherrier; Peter J Webb; Susan Y Tamura; P Douglas Boatman; Carleton R Sage; Thomas O Schrader; Ruoping Chen; Steven L Colletti; James R Tata; M Gerard Waters; Kang Cheng; Andrew K Taggart; Tian-Quan Cai; Ester Carballo-Jane; Dominic P Behan; Daniel T Connolly; Jeremy G Richman
3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.
Journal of medicinal chemistry 2008;51(16):5101-8.
2008: Amjad Ali; James M Balkovec; Mark Greenlee; Milton L Hammond; Greg Rouen; Gayle Taylor; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Michael J Forrest; Ester Carballo-Jane; Silvi Luell; Karen Lowitz; Denise visco
Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.
Bioorganic & medicinal chemistry 2008;16(16):7535-42.
2007: Hong Shen; Michael J Szymonifka; Divya Kharbanda; Qiaolin Deng; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Junying Wang; Xinchun Tong; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.
Bioorganic & medicinal chemistry letters 2007;17(24):6723-8.
2007: Hong Shen; Fa-Xiang Ding; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K Taggart; Ning Ren; Tian-Quan Cai; Qiaolin Deng; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Journal of medicinal chemistry 2007;50(25):6303-6.
2007: Stephen J O'Keefe; John S Mudgett; Susan Cupo; Janey N Parsons; Nicole A Chartrain; Catherine E Fitzgerald; Shiow-Ling Chen; Karen Lowitz; Cordelia Rasa; Denise visco; Silvi Luell; Ester Carballo-Jane; Karen Owens; Dennis Zaller
Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation.
The Journal of biological chemistry 2007;282(48):34663-71.
2007: Ester Carballo-Jane; Lynn S Gerckens; Silvi Luell; Allison S Parlapiano; Michael Wolff; Steven L Colletti; James R Tata; Andrew K P Taggart; M Gerard Waters; Jeremy G Richman; Margaret E McCann; Michael J Forrest
Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.
Journal of pharmacological and toxicological methods 2007;56(3):308-16.
2007: Christopher F Thompson; Nazia Quraishi; Amjad Ali; Ralph T Mosley; James R Tata; Milton L Hammond; James M Balkovec; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Douglas Miller; Ting-ting D Yamin; Chris Thompson; Edward A O'Neill; Dennis Zaller; Michael J Forrest; Ester Carballo-Jane; Silvi Luell
Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.
Bioorganic & medicinal chemistry letters 2007;17(12):3354-61.
2007: Ester Carballo-Jane; T Ciecko; Silvi Luell; John W Woods; Emanuel Zycband; M Gerard Waters; Michael J Forrest
Potential role for epidermal Langerhans cells in nicotinic acid-induced vasodilatation in the mouse.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2007;56(6):254-61.
2006: Swaminathan R Natarajan; Luping Liu; Mark Levorse; James E Thompson; Edward A O'Neill; Stephen J O'Keefe; Kalpit A Vora; Raymond J Cvetovich; John Y L Chung; Ester Carballo-Jane; Denise visco
p38 MAP kinase inhibitors. Part 5: discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold.
Bioorganic & medicinal chemistry letters 2006;16(20):5468-71.
2005: Cameron J Smith; Amjad Ali; James M Balkovec; Donald W Graham; Milton L Hammond; Gool F Patel; Gregory P Rouen; Scott K Smith; James R Tata; Monica Einstein; Lan Ge; Georgianna S Harris; Theresa M Kelly; Paul Mazur; Chris Thompson; Chuanlin F Wang; Joanne M Williamson; Douglas Miller; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Ting-ting D Yamin; Edward A O'Neill; Dennis Zaller; Ester Carballo-Jane; Michael J Forrest; Silvi Luell
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.
Bioorganic & medicinal chemistry letters 2005;15(11):2926-31.
2005: Christopher F Thompson; Nazia Quraishi; Amjad Ali; James R Tata; Milton L Hammond; James M Balkovec; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Douglas Miller; Ting-ting D Yamin; Chris Thompson; Edward A O'Neill; Dennis Zaller; Michael J Forrest; Ester Carballo-Jane; Silvi Luell
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Bioorganic & medicinal chemistry letters 2005;15(8):2163-7.
2004: Amjad Ali; Christopher F Thompson; James M Balkovec; Donald W Graham; Milton L Hammond; Nazia Quraishi; James R Tata; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Douglas Miller; Chris Thompson; Dennis Zaller; Michael J Forrest; Ester Carballo-Jane; Silvi Luell
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Journal of medicinal chemistry 2004;47(10):2441-52.
2004: Ester Carballo-Jane; Shilpa Pandit; Joseph C Santoro; Concetta Freund; Silvi Luell; Georgianna Harris; Michael J Forrest; Ayesha Sitlani
Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation.
The Journal of steroid biochemistry and molecular biology 2004;88(2):191-201.