FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Dick Heinegård

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Procedures

Co-author Network

Publications

TOP 3
Dick Heinegård
Extracellular matrix: pathobiology and signaling.
Lisbet Haglund; Viveka Tillgren; Patrik Onnerfjord; Dick Heinegård
The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains.
Camilla Melin Fürst; Matthias Mörgelin; Kasper Vadstrup; Anders Aspberg; Dick Heinegård; Anna Blom
The C-type lectin of the aggrecan g3 domain activates complement.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Dick Heinegård (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Dick Heinegård
Extracellular matrix: pathobiology and signaling.
Biological chemistry 2013;394(6):805-6.
2013: Lisbet Haglund; Viveka Tillgren; Patrik Onnerfjord; Dick Heinegård
The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains.
The Journal of biological chemistry 2013;288(2):995-1008.
2013: Camilla Melin Fürst; Matthias Mörgelin; Kasper Vadstrup; Anders Aspberg; Dick Heinegård; Anna Blom
The C-type lectin of the aggrecan g3 domain activates complement.
PloS one 2013;8(4):e61407.
2013: Fredrik Södersten; Dick Heinegård; Kjell Hultenby; Christopher Johnston; Stina Ekman
Immunolocalization of collagens (I and III) and cartilage oligomeric matrix protein in the normal and injured equine superficial digital flexor tendon.
Connective tissue research 2013;54(1):62-9.
2012: Kaisa E Happonen; Dick Heinegård; Tore Saxne; Anna M Blom
Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases.
Immunobiology 2012;217(11):1088-96.
2012: Pallavi Agarwal; Katrin Blumbach; Dick Heinegård; Douglas R Keene; Manuel Koch; Thomas Krieg; Mats Paulsson; Jan-Niklas Schulz; Frank Zaucke; Daniela Zwolanek; Beate Eckes
Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.
The Journal of biological chemistry 2012;287(27):22549-59.
2012: Patrik Onnerfjord; Areej Khabut; Finn P Reinholt; Olle Svensson; Dick Heinegård
Quantitative proteomic analysis of eight cartilaginous tissues reveals characteristic differences as well as similarities between subgroups.
The Journal of biological chemistry 2012;287(23):18913-24.
2012: Kristina Rydell-Törmänen; Tore Saxne; Kristofer Andréasson; Dick Heinegård; R Hesselstrand; Juha Risteli; Gunilla Westergren-Thorsson
Extracellular matrix alterations and acute inflammation; developing in parallel during early induction of pulmonary fibrosis.
Laboratory investigation; a journal of technical methods and pathology 2012;92(6):917-25.
2012: Kaisa E Happonen; Dick Heinegård; Tore Saxne; Camilla Melin Fürst; Anna M Blom
PRELP protein inhibits the formation of the complement membrane attack complex.
The Journal of biological chemistry 2012;287(11):8092-100.
2012: Kaisa E Happonen; Dick Heinegård; R Hesselstrand; Tore Saxne; Maria Andersson; Anders A Bengtsson; Pierre Geborek; Anna M Blom
Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment.
Arthritis research & therapy 2012;14(1):R15.
2011: Dick Heinegård; Josef S Smolen
Diseases of the musculosketelal system. Preface.
Best practice & research. Clinical rheumatology 2011;25(6):749-50.
2011: Nikolina Kalchishkova; Camilla Melin Fürst; Dick Heinegård; Anna M Blom
NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H.
The Journal of biological chemistry 2011;286(32):27915-26.
2011: Lisbet Haglund; Viveka Tillgren; Laura Addis; Christina Wenglén; Anneliese Recklies; Dick Heinegård
Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment.
The Journal of biological chemistry 2011;286(5):3925-34.
2011: Antonis Skliris; Kaisa E Happonen; Evangelos Terpos; Vassiliki Labropoulou; Magne Børset; Dick Heinegård; Anna M Blom; Achilleas D Theocharis
Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: implications for multiple myeloma.
European journal of immunology 2011;41(2):437-49.
2011: Dick Heinegård; Tore Saxne
The role of the cartilage matrix in osteoarthritis.
Nature reviews. Rheumatology 2011;7(1):50-6.
2011: Matthew R W Smith; Ian M Wright; Gaynor J Minshall; Jay Dudhia; Kristien Verheyen; Dick Heinegård; Roger K W Smith
Increased cartilage oligomeric matrix protein concentrations in equine digital flexor tendon sheath synovial fluid predicts intrathecal tendon damage.
Veterinary surgery : VS 2011;40(1):54-8.
2010: Kaisa E Happonen; Tore Saxne; Anders Aspberg; Matthias Mörgelin; Dick Heinegård; Anna M Blom
Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis.
Arthritis and rheumatism 2010;62(12):3574-83.
2010: Tijs van Wieringen; Sebastian Kalamajski; Asa Lidén; Dominique Bihan; Bengt Guss; Dick Heinegård; Richard W Farndale; Kristofer Rubin
The streptococcal collagen-binding protein CNE specifically interferes with alphaVbeta3-mediated cellular interactions with triple helical collagen.
The Journal of biological chemistry 2010;285(46):35803-13.
2010: E Skiöldebrand; Stina Ekman; Dick Heinegård; K Hultenby
Ultrastructural immunolocalization of cartilage oligomeric matrix protein (COMP) in the articular cartilage on the equine third carpal bone in trained and untrained horses.
Research in veterinary science 2010;88(2):251-7.
2010: Eva-Lena Stattin; Fredrik Wiklund; Karin Lindblom; Patrik Onnerfjord; Björn-Anders Jonsson; Yelverton Tegner; Takako Sasaki; André Struglics; Stefan Lohmander; Niklas Dahl; Dick Heinegård; Anders Aspberg
A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans.
American journal of human genetics 2010;86(2):126-37.
2010: S G Petersen; T Saxne; Dick Heinegård; M Hansen; L Holm; S Koskinen; C Stordal; H Christensen; P Aagaard; M Kjaer
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(1):34-40.
2009: Dick Heinegård
Proteoglycans and more--from molecules to biology.
International journal of experimental pathology 2009;90(6):575-86.
2009: Nadia Rucci; Anna Rufo; Marina Alamanou; mattia capulli; Andrea Del Fattore; Emma Ahrman; Daria Capece; Valeria Iansante; Francesca Zazzeroni; Edoardo Alesse; Dick Heinegård; Anna Teti
The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis.
The Journal of cell biology 2009;187(5):669-83.
2009: Viveka Tillgren; Patrik Onnerfjord; Lisbet Haglund; Dick Heinegård
The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors.
The Journal of biological chemistry 2009;284(42):28543-53.
2009: G A Manderson; M Martin; P Onnerfjord; T Saxne; A Schmidtchen; T E Mollnes; Dick Heinegård; Anna Blom
Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system.
Molecular immunology 2009;46(16):3388-98.
2009: Sebastian Kalamajski; Anders Aspberg; Karin Lindblom; Dick Heinegård; Ake Oldberg
Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization.
The Biochemical journal 2009;423(1):53-9.
2009: Kaisa E Happonen; Andreas P Sjöberg; Matthias Mörgelin; Dick Heinegård; Anna M Blom
Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1518-25.
2009: Andreas P Sjöberg; Gavin A Manderson; Matthias Mörgelin; Anthony J Day; Dick Heinegård; Anna Blom
Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation.
Molecular immunology 2009;46(5):830-9.
2008: R Hesselstrand; Anja Kassner; Dick Heinegård; Tore Saxne
COMP: a candidate molecule in the pathogenesis of systemic sclerosis with a potential as a disease marker.
Annals of the rheumatic diseases 2008;67(9):1242-8.
2008: Anna Pramhed; Laura Addis; Viveka Tillgren; Christina Wenglén; Dick Heinegård; Derek Logan
Purification, crystallization and preliminary X-ray diffraction analysis of human chondroadherin.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):516-9.
2008: Ahnders Franzén; Kjell Hultenby; Finn P Reinholt; Patrik Onnerfjord; Dick Heinegård
Altered osteoclast development and function in osteopontin deficient mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(5):721-8.
2008: Cordula Surmann-Schmitt; Uwe Dietz; Trayana Kireva; Nadia Adam; Jung Park; Andreas Tagariello; Patrik Onnerfjord; Dick Heinegård; Ursula Schlötzer-Schrehardt; Rainer Deutzmann; Klaus von der Mark; Michael Stock
Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis.
The Journal of biological chemistry 2008;283(11):7082-93.
2008: Asa Lidén; Tijs van Wieringen; Jonas Lannergård; Anja Kassner; Dick Heinegård; Rolf K Reed; Bengt Guss; Kristofer Rubin
A secreted collagen- and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure.
The Journal of biological chemistry 2008;283(3):1234-42.
2007: Mikael Danfelter; Patrik Onnerfjord; Dick Heinegård
Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain.
The Journal of biological chemistry 2007;282(51):36933-41.
2007: Krisztina Halász; Anja Kassner; Matthias Mörgelin; Dick Heinegård
COMP acts as a catalyst in collagen fibrillogenesis.
The Journal of biological chemistry 2007;282(43):31166-73.
2007: Katarzyna Piróg; Roger S Meadows; Lynette Knowles; Dick Heinegård; David J Thornton; Karl Kadler; Raymond P Boot-Handford; Michael D Briggs
Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.
Human molecular genetics 2007;16(17):2072-88.
2007: Jayesh Dudhia; Charlotte M Scott; Edward Draper; Dick Heinegård; Andrew A Pitsillides; R K W Smith
Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity.
Aging cell 2007;6(4):547-56.
2007: Andreas P Sjöberg; Leendert A Trouw; Simon J Clark; Jonatan Sjölander; Dick Heinegård; Robert B Sim; Anthony J Day; Anna Blom
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells.
The Journal of biological chemistry 2007;282(15):10894-900.
2007: Walter P Maksymowych; Robert Landewe; Maarten Boers; Patrick Garnero; Piet Geusens; Hani El-Gabalawy; Dick Heinegård; Virginia B Kraus; Virginia Krause; Stefan Lohmander; John R Matyas; Tore Saxne; Désirée van der Heijde
Development of draft validation criteria for a soluble biomarker to be regarded as a valid biomarker reflecting structural damage endpoints in rheumatoid arthritis and spondyloarthritis clinical trials.
The Journal of rheumatology 2007;34(3):634-40.
2007: Fredrik Södersten; Stina Ekman; Anja Niehoff; Frank Zaucke; Dick Heinegård; Kjell Hultenby
Ultrastructural immunolocalization of cartilage oligomeric matrix protein, thrombospondin-4, and collagen fibril size in rodent achilles tendon in relation to exercise.
Connective tissue research 2007;48(5):254-62.
2007: Marcin Okroj; Dick Heinegård; Rikard Holmdahl; Anna Blom
Rheumatoid arthritis and the complement system.
Annals of medicine 2007;39(7):517-30.
2006: E Skiöldebrand; Dick Heinegård; B Olofsson; G Rucklidge; N Ronéus; Stina Ekman
Altered homeostasis of extracellular matrix proteins in joints of standardbred trotters during a long-term training programme.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 2006;53(9):445-9.
2006: M L E Andersson; Ingemar F Petersson; K E Karlsson; E N Jonsson; Bengt Månsson; Dick Heinegård; Tore Saxne
Diurnal variation in serum levels of cartilage oligomeric matrix protein in patients with knee osteoarthritis or rheumatoid arthritis.
Annals of the rheumatic diseases 2006;65(11):1490-4.
2006: Douglas Charles Bauer; D J Hunter; Steven B Abramson; Mukundan Attur; M Corr; David T Felson; D Heinegård; Joanne M Jordan; Thomas B Kepler; Nancy E Lane; Dick Heinegård; B Tyree; Virginia B Kraus
Classification of osteoarthritis biomarkers: a proposed approach.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(8):723-7.
2006: Frances M K Williams; Toby Andrew; Tore Saxne; Dick Heinegård; Tim D Spector; Alex J MacGregor
The heritable determinants of cartilage oligomeric matrix protein.
Arthritis and rheumatism 2006;54(7):2147-51.
2006: Haoyu Feng; Mikael Danfelter; Björn Strömqvist; Dick Heinegård
Extracellular matrix in disc degeneration.
The Journal of bone and joint surgery. American volume 2006;88 Suppl 2():25-9.
2006: Maria L E Andersson; Carina A Thorstensson; Ewa M Roos; Ingemar F Petersson; Dick Heinegård; Tore Saxne
Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis.
BMC musculoskeletal disorders 2006;7():98.
2005: Andreas P Sjöberg; Patrik Onnerfjord; Matthias Mörgelin; Dick Heinegård; Anna Blom
The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q.
The Journal of biological chemistry 2005;280(37):32301-8.
2005: Fredrik Södersten; Stina Ekman; Maija-Leena Eloranta; Dick Heinegård; Jayesh Dudhia; Kjell Hultenby
Ultrastructural immunolocalization of cartilage oligomeric matrix protein (COMP) in relation to collagen fibrils in the equine tendon.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(5):376-85.
2005: Elisabet Lindqvist; Kerstin Eberhardt; Klaus Bendtzen; Dick Heinegård; Tore Saxne
Prognostic laboratory markers of joint damage in rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(2):196-201.
2005: Stina Ekman; E Skiöldebrand; Dick Heinegård; K Hultenby
Ultrastructural immunolocalisation of bone sialoprotein in the osteocartilagenous interface of the equine third carpal bone.
Equine veterinary journal 2005;37(1):26-30.
2005: E Skiöldebrand; Dick Heinegård; Maija-Leena Eloranta; G Nilsson; Jayesh Dudhia; B Sandgren; Stina Ekman
Enhanced concentration of COMP (cartilage oligomeric matrix protein) in osteochondral fractures from racing Thoroughbreds.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005;23(1):156-63.
2004: Jörg Schedel; Christina Wenglén; Oliver Distler; Ulf Müller-Ladner; Jurgen Schölmerich; Dick Heinegård; Veit Krenn
Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis.
Scandinavian journal of immunology 2004;60(5):514-23.
2004: Pilar Lorenzo; Michael T Bayliss; Dick Heinegård
Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis.
Matrix biology : journal of the International Society for Matrix Biology 2004;23(6):381-91.
2004: Asa Ström; Ahnders Franzén; Christel Wängnerud; Ann-Katrin Knutsson; Dick Heinegård; Anna Hultgårdh-Nilsson
Altered vascular remodeling in osteopontin-deficient atherosclerotic mice.
Journal of vascular research 2004;41(4):314-22.
2004: Tero Pihlajamaa; Hilkka Lankinen; Joni Ylöstalo; Leena Valmu; Juha Jäälinoja; Frank Zaucke; Luitgard Spitznagel; Silke Gösling; Anne Puustinen; Dick Heinegård; Johan Peränen; Patrik Maurer; Leena Ala-Kokko; Ilkka Kilpelaïnen
Characterization of recombinant amino-terminal NC4 domain of human collagen IX: interaction with glycosaminoglycans and cartilage oligomeric matrix protein.
The Journal of biological chemistry 2004;279(23):24265-73.
2004: Asa Ström; E Ahlqvist; Ahnders Franzén; Dick Heinegård; Anna Hultgårdh-Nilsson
Extracellular matrix components in atherosclerotic arteries of Apo E/LDL receptor deficient mice: an immunohistochemical study.
Histology and histopathology 2004;19(2):337-47.
2004: Ann-Sofie Hansson; Martina Johannesson; Lars Svensson; Kutty Selva Nandakumar; Dick Heinegård; Rikard Holmdahl
Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease.
The American journal of pathology 2004;164(3):959-66.
2004: Terrence F Heathfield; Patrik Onnerfjord; Leif Dahlberg; Dick Heinegård
Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13.
The Journal of biological chemistry 2004;279(8):6286-95.
2004: Anna Johnson; Roger Smith; Tore Saxne; Mark Hickery; Dick Heinegård
Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant cultures.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(2):149-59.
2004: Patrik Onnerfjord; Terrence F Heathfield; Dick Heinegård
Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.
The Journal of biological chemistry 2004;279(1):26-33.
2004: S A Goodman; S A May; Dick Heinegård; R K W Smith
Tenocyte response to cyclical strain and transforming growth factor beta is dependent upon age and site of origin.
Biorheology 2004;41(5):613-28.
2003: Charlotte Wiberg; Andreas R Klatt; Raimund Wagener; Mats Paulsson; John F Bateman; Dick Heinegård; Matthias Mörgelin
Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan.
The Journal of biological chemistry 2003;278(39):37698-704.
2003: David A Carrino; Patrik Onnerfjord; John D Sandy; Gabriella Cs-Szabo; Paul G Scott; J Michael Sorrell; Dick Heinegård; Arnold I Caplan
Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin.
The Journal of biological chemistry 2003;278(19):17566-72.
2003: Sally C Dickinson; Mireille N Vankemmelbeke; David J Buttle; Krisztina Rosenberg; Dick Heinegård; Anthony P Hollander
Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs.
Matrix biology : journal of the International Society for Matrix Biology 2003;22(3):267-78.
2003: Thomas Blom; Ahnders Franzén; Dick Heinegård; Rikard Holmdahl
Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease".
Science (New York, N.Y.) 2003;299(5614):1845; author reply 1845.
2003: Dick Heinegård; Lars Lidgren; Tore Saxne
Recent developments and future research in the bone and joint decade 2000-2010.
Bulletin of the World Health Organization 2003;81(9):686-8.
2003: Gabriele Carlinfante; Daphne Vassiliou; Olle Svensson; Mikael Wendel; Dick Heinegård; Göran Andersson
Differential expression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma.
Clinical & experimental metastasis 2003;20(5):437-44.
2003: Meliha Crnkic; Bengt Månsson; Lotta Larsson; Pierre Geborek; Dick Heinegård; Tore Saxne
Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept.
Arthritis research & therapy 2003;5(4):R181-5.
2003: V E Ramstad; Ahnders Franzén; Dick Heinegård; Mikael Wendel; Finn P Reinholt
Ultrastructural distribution of osteoadherin in rat bone shows a pattern similar to that of bone sialoprotein.
Calcified tissue international 2003;72(1):57-64.
2002: Charlotte Wiberg; Dick Heinegård; Christina Wenglén; Rupert Timpl; Matthias Mörgelin
Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures.
The Journal of biological chemistry 2002;277(51):49120-6.
2002: Liz Svensson; Attila Aszódi; Dick Heinegård; Ernst B Hunziker; Finn P Reinholt; Reinhard Fässler; Ake Oldberg
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.
Molecular and cellular biology 2002;22(12):4366-71.
2002: Eva Bengtsson; Matthias Mörgelin; Takako Sasaki; Rupert Timpl; Dick Heinegård; Anders Aspberg
The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor.
The Journal of biological chemistry 2002;277(17):15061-8.
2001: A S Hansson; Dick Heinegård; J C Piette; H Burkhardt; Rikard Holmdahl
The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis.
Arthritis and rheumatism 2001;44(10):2402-12.
2001: B Mansson; Christina Wenglén; Matthias Mörgelin; T Saxne; Dick Heinegård
Association of chondroadherin with collagen type II.
The Journal of biological chemistry 2001;276(35):32883-8.
2001: Kerstin Tiedemann; T Larsson; Dick Heinegård; Anders Malmström
The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis.
Archives of biochemistry and biophysics 2001;391(1):65-71.
2001: Charlotte Wiberg; E Hedbom; A Khairullina; Shireen R Lamandé; Ake Oldberg; Rupert Timpl; Matthias Mörgelin; Dick Heinegård
Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix.
The Journal of biological chemistry 2001;276(22):18947-52.
2001: Pilar Lorenzo; Anders Aspberg; Patrik Onnerfjord; Michael T Bayliss; peter neame; Dick Heinegård
Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan.
The Journal of biological chemistry 2001;276(15):12201-11.
2001: J Thur; K Rosenberg; D Patric Nitsche; Tero Pihlajamaa; Leena Ala-Kokko; Dick Heinegård; Mats Paulsson; Patrik Maurer
Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX.
The Journal of biological chemistry 2001;276(9):6083-92.
2001: Anders I Olin; Matthias Mörgelin; Takako Sasaki; Rupert Timpl; Dick Heinegård; Anders Aspberg
The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.
The Journal of biological chemistry 2001;276(2):1253-61.
2001: L Svensson; Ake Oldberg; Dick Heinegård
Collagen binding proteins.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9 Suppl A():S23-8.
2001: Audrey McAlinden; Jayesh Dudhia; M C Bolton; P Lorenzo; Dick Heinegård; Michael T Bayliss
Age-related changes in the synthesis and mRNA expression of decorin and aggrecan in human meniscus and articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(1):33-41.
2001: B Mânsson; Anders Gülfe; Pierre Geborek; Dick Heinegård; Tore Saxne
Release of cartilage and bone macromolecules into synovial fluid: differences between psoriatic arthritis and rheumatoid arthritis.
Annals of the rheumatic diseases 2001;60(1):27-31.
2000: Eva Bengtsson; Anders Aspberg; Dick Heinegård; Y Sommarin; D Spillmann
The amino-terminal part of PRELP binds to heparin and heparan sulfate.
The Journal of biological chemistry 2000;275(52):40695-702.
2000: Heli Salminen; Maritta Perälä; P Lorenzo; Dick Heinegård; D Heinegård; Anna-Marja Säämänen; Eero Vuorio
Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis.
Arthritis and rheumatism 2000;43(8):1742-8.
2000: Bengt Månsson; Dick Heinegård; Tore Saxne
Diagnosis of osteoarthritis in relation to molecular processes in cartilage: comment on the article by Clark et al.
Arthritis and rheumatism 2000;43(6):1425-7.
1999: Z Shen; S Gantcheva; Y Sommarin; Dick Heinegård
Tissue distribution of a novel cell binding protein, osteoadherin, in the rat.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(6):533-42.
1999: Leo A B Joosten; Monique M A Helsen; Tore Saxne; Fons A J van de Loo; Dick Heinegård; Wim B van den Berg
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):5049-55.
1999: Pilar Lorenzo; Pierre Aman; Y Sommarin; Dick Heinegård
The human CILP gene: exon/intron organization and chromosomal mapping.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(5):445-54.
1999: A S Hansson; Dick Heinegård; Rikard Holmdahl
A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1).
The Journal of clinical investigation 1999;104(5):589-98.
1999: Anders Aspberg; S Adam; Günter Kostka; Rupert Timpl; Dick Heinegård
Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican.
The Journal of biological chemistry 1999;274(29):20444-9.
1999: L Svensson; Attila Aszódi; Finn P Reinholt; Reinhard Fässler; Dick Heinegård; Ake Oldberg
Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon.
The Journal of biological chemistry 1999;274(14):9636-47.
1999: J F Bleasel; A R Poole; Dick Heinegård; T Saxne; D Holderbaum; M Ionescu; P Jones; Roland W Moskowitz
Changes in serum cartilage marker levels indicate altered cartilage metabolism in families with the osteoarthritis-related type II collagen gene COL2A1 mutation.
Arthritis and rheumatism 1999;42(1):39-45.
1998: AJ Reardon; Dick Heinegård; david mcleod; John K Sheehan; Paul N Bishop
The large chondroitin sulphate proteoglycan versican in mammalian vitreous.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(5):325-33.
1998: Pilar Lorenzo; P Neame; Y Sommarin; Dick Heinegård
Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase.
The Journal of biological chemistry 1998;273(36):23469-75.
1998: Pilar Lorenzo; M T Bayliss; Dick Heinegård
A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age.
The Journal of biological chemistry 1998;273(36):23463-8.
1998: Thierry Conrozier; Dick Heinegård; C S Fan; Pierre Mathieu; AM Tron; D Heinegård; Eric Vignon
Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: a one year prospective study.
Annals of the rheumatic diseases 1998;57(9):527-32.
1998: K Rosenberg; H Olsson; Matthias Mörgelin; Dick Heinegård
Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen.
The Journal of biological chemistry 1998;273(32):20397-403.
1998: Mikael Wendel; Y Sommarin; Dick Heinegård
Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone.
The Journal of cell biology 1998;141(3):839-47.
1998: Ingemar F Petersson; Torsten Boegård; J Dahlström; Björn Svensson; Dick Heinegård; Tore Saxne
Bone scan and serum markers of bone and cartilage in patients with knee pain and osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(1):33-9.
1998: Ingemar F Petersson; Torsten Boegård; Björn Svensson; Dick Heinegård; Tore Saxne
Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint.
British journal of rheumatology 1998;37(1):46-50.
1998: C Landgren; David Beier; R Fässler; Dick Heinegård; Y Sommarin
The mouse chondroadherin gene: characterization and chromosomal localization.
Genomics 1998;47(1):84-91.
1996: N Hauser; Mats Paulsson; D Heinegârd; Dick Heinegård
Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation.
The Journal of biological chemistry 1996;271(50):32247-52.
1996: Edin de Bri; Finn P Reinholt; Dick Heinegård; Silwa Mengarelli-Widholm; M Norgård; Olle Svensson
Bone sialoprotein and osteopontin distribution at the osteocartilaginous interface.
Clinical orthopaedics and related research 1996;(330):251-60.
1996: M E Flores; Dick Heinegård; Finn P Reinholt; Göran Andersson
Bone sialoprotein coated on glass and plastic surfaces is recognized by different beta 3 integrins.
Experimental cell research 1996;227(1):40-6.
1995: Z Shen; Dick Heinegård; Y Sommarin
Distribution and expression of cartilage oligomeric matrix protein and bone sialoprotein show marked changes during rat femoral head development.
Matrix biology : journal of the International Society for Matrix Biology 1995;14(9):773-81.
1995: E Bengtsson; Peter J Neame; Dick Heinegård; Y Sommarin
The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues.
The Journal of biological chemistry 1995;270(43):25639-44.
1995: L Svensson; Dick Heinegård; A Oldberg
Decorin-binding sites for collagen type I are mainly located in leucine-rich repeats 4-5.
The Journal of biological chemistry 1995;270(35):20712-6.
1995: Kjell Hultenby; Finn P Reinholt; Dick Heinegård; Göran Andersson; S C Marks
Osteopontin: a ligand for the alpha v beta 3 integrin of the osteoclast clear zone in osteopetrotic (ia/ia) rats.
Annals of the New York Academy of Sciences 1995;760():315-8.
1995: Dick Heinegård; G Andersson; Finn P Reinholt
Roles of osteopontin in bone remodeling.
Annals of the New York Academy of Sciences 1995;760():213-22.
1995: Dick Heinegård; M Paulsson; D Heinegård; U Aebi; J Engel
Evidence of a defined spatial arrangement of hyaluronate in the central filament of cartilage proteoglycan aggregates.
The Biochemical journal 1995;307 ( Pt 2)():595-601.
1995: Mikael Wendel; Y Sommarin; T Bergman; Dick Heinegård
Isolation, characterization, and primary structure of a calcium-binding 63-kDa bone protein.
The Journal of biological chemistry 1995;270(11):6125-33.
1995: Dick Heinegård
Studies of bone matrix molecules give us insights into bone remodelling.
Experientia 1995;51(3):195-6.
1994: F Cheng; Dick Heinegård; Anders Malmström; A Schmidtchen; K Yoshida; Lars-Ake Fransson
Patterns of uronosyl epimerization and 4-/6-O-sulphation in chondroitin/dermatan sulphate from decorin and biglycan of various bovine tissues.
Glycobiology 1994;4(5):685-96.
1994: Peter J Neame; Y Sommarin; R E Boynton; Dick Heinegård
The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage.
The Journal of biological chemistry 1994;269(34):21547-54.
1994: A Yacoub; Per Lindahl; Kristofer Rubin; Mikael Wendel; Dick Heinegård; Cecilia Rydén
Purification of a bone sialoprotein-binding protein from Staphylococcus aureus.
European journal of biochemistry / FEBS 1994;222(3):919-25.
1994: B Ek-Rylander; M Flores; Mikael Wendel; Dick Heinegård; Göran Andersson
Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro.
The Journal of biological chemistry 1994;269(21):14853-6.
1994: M Mörgelin; Dick Heinegård; J Engel; M Paulsson
The cartilage proteoglycan aggregate: assembly through combined protein-carbohydrate and protein-protein interactions.
Biophysical chemistry 1994;50(1-2):113-28.
1994: Kjell Hultenby; Finn P Reinholt; M Norgård; A Oldberg; Mikael Wendel; Dick Heinegård
Distribution and synthesis of bone sialoprotein in metaphyseal bone of young rats show a distinctly different pattern from that of osteopontin.
European journal of cell biology 1994;63(2):230-9.
1994: H Hedlund; Silwa Mengarelli-Widholm; Dick Heinegård; Finn P Reinholt; Olle Svensson
Fibromodulin distribution and association with collagen.
Matrix biology : journal of the International Society for Matrix Biology 1994;14(3):227-32.
1993: E Hedbom; Dick Heinegård
Binding of fibromodulin and decorin to separate sites on fibrillar collagens.
The Journal of biological chemistry 1993;268(36):27307-12.
1993: Kjell Hultenby; Finn P Reinholt; Dick Heinegård
Distribution of integrin subunits on rat metaphyseal osteoclasts and osteoblasts.
European journal of cell biology 1993;62(1):86-93.
1993: P Antonsson; Dick Heinegård; A Oldberg
Structure and deduced amino acid sequence of the human fibromodulin gene.
Biochimica et biophysica acta 1993;1174(2):204-6.
1993: Gunilla Westergren-Thorsson; J Hernnäs; B Särnstrand; Dick Heinegård; D Heinegård; Anders Malmström
Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats.
The Journal of clinical investigation 1993;92(2):632-7.
1993: M Wendel; Dick Heinegård; A Franzén
A major non-collagenous 62 kDa protein from rat bone mineralized matrix is identical to pp63 a phosphorylated glycoprotein from liver.
Matrix (Stuttgart, Germany) 1993;13(4):331-9.
1992: F Cheng; K Yoshida; Dick Heinegård; Lars-Ake Fransson
A new method for sequence analysis of glycosaminoglycans from heavily substituted proteoglycans reveals non-random positioning of 4- and 6-O-sulphated N-acetylgalactosamine in aggrecan-derived chondroitin sulphate.
Glycobiology 1992;2(6):553-61.
1992: A Oldberg; P Antonsson; K Lindblom; Dick Heinegård
COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins.
The Journal of biological chemistry 1992;267(31):22346-50.
1992: M E Flores; M Norgård; Dick Heinegård; Finn P Reinholt; Göran Andersson
RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein, and fibronectin.
Experimental cell research 1992;201(2):526-30.
1992: Dick Heinegård; Jürgen Engel; D Heinegård; M Paulsson
Proteoglycans from the swarm rat chondrosarcoma. Structure of the aggregates extracted with associative and dissociative solvents as revealed by electron microscopy.
The Journal of biological chemistry 1992;267(20):14275-84.
1992: E Hedbom; P Antonsson; A Hjerpe; D Aeschlimann; M Paulsson; E Rosa-Pimentel; Y Sommarin; Mikael Wendel; A Oldberg; Dick Heinegård
Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.
The Journal of biological chemistry 1992;267(9):6132-6.
1991: T Larsson; R M Aspden; Dick Heinegård
Effects of mechanical load on cartilage matrix biosynthesis in vitro.
Matrix (Stuttgart, Germany) 1991;11(6):388-94.
1991: R M Aspden; T Larsson; R Svensson; Dick Heinegård
Computer-controlled mechanical testing machine for small samples of biological viscoelastic materials.
Journal of biomedical engineering 1991;13(6):521-5.
1991: T Larsson; Y Sommarin; M Paulsson; P Antonsson; E Hedbom; Mikael Wendel; Dick Heinegård
Cartilage matrix proteins. A basic 36-kDa protein with a restricted distribution to cartilage and bone.
The Journal of biological chemistry 1991;266(30):20428-33.
1991: P Antonsson; Dick Heinegård; A Oldberg
Posttranslational modifications of fibromodulin.
The Journal of biological chemistry 1991;266(25):16859-61.
1991: Kjell Hultenby; Finn P Reinholt; A Oldberg; Dick Heinegård
Ultrastructural immunolocalization of osteopontin in metaphyseal and cortical bone.
Matrix (Stuttgart, Germany) 1991;11(3):206-13.
1991: Gunilla Westergren-Thorsson; P Antonsson; Anders Malmström; Dick Heinegård; A Oldberg
The synthesis of a family of structurally related proteoglycans in fibroblasts is differently regulated by TFG-beta.
Matrix (Stuttgart, Germany) 1991;11(3):177-83.
1990: A Oldberg; P Antonsson; E Hedbom; Dick Heinegård
Structure and function of extracellular matrix proteoglycans.
Biochemical Society transactions 1990;18(5):789-92.
1990: M Silbermann; Klaus von der Mark; Dick Heinegård
An immunohistochemical study of the distribution of matrical proteins in the mandibular condyle of neonatal mice. II. Non-collagenous proteins.
Journal of anatomy 1990;170():23-31.
1990: Finn P Reinholt; Kjell Hultenby; A Oldberg; Dick Heinegård
Osteopontin--a possible anchor of osteoclasts to bone.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4473-5.
1990: Dick Heinegård; E Hedbom; P Antonsson; A Oldberg
Structural variability of large and small chondroitin sulphate/dermatan sulphate proteoglycans.
Biochemical Society transactions 1990;18(2):209-12.
1989: A Oldberg; B Jirskog-Hed; S Axelsson; Dick Heinegård
Regulation of bone sialoprotein mRNA by steroid hormones.
The Journal of cell biology 1989;109(6 Pt 1):3183-6.
1989: T Larsson; R M Aspden; Dick Heinegård
Large cartilage proteoglycan (PG-LA) influences the biosynthesis of macromolecules by isolated chondrocytes.
Matrix (Stuttgart, Germany) 1989;9(5):343-52.
1989: P Antonsson; Dick Heinegård; A Oldberg
The keratan sulfate-enriched region of bovine cartilage proteoglycan consists of a consecutively repeated hexapeptide motif.
The Journal of biological chemistry 1989;264(27):16170-3.
1989: Cecilia Rydén; A I Yacoub; I Maxe; Dick Heinegård; A Oldberg; A Franzén; A Ljungh; Kristofer Rubin
Specific binding of bone sialoprotein to Staphylococcus aureus isolated from patients with osteomyelitis.
European journal of biochemistry / FEBS 1989;184(2):331-6.
1989: Y Sommarin; T Larsson; Dick Heinegård
Chondrocyte-matrix interactions. Attachment to proteins isolated from cartilage.
Experimental cell research 1989;184(1):181-92.
1989: Gila Maor; Ze'ev Hochberg; K von der Mark; Dick Heinegård; M Silbermann
Human growth hormone enhances chondrogenesis and osteogenesis in a tissue culture system of chondroprogenitor cells.
Endocrinology 1989;125(3):1239-45.
1989: A Oldberg; P Antonsson; K Lindblom; Dick Heinegård
A collagen-binding 59-kd protein (fibromodulin) is structurally related to the small interstitial proteoglycans PG-S1 and PG-S2 (decorin).
The EMBO journal 1989;8(9):2601-4.
1989: A Franzen; Dick Heinegård; M Solursh
Possible recruitment of osteoblastic precursor cells from hypertrophic chondrocytes during initial osteogenesis in cartilaginous limbs of young rats.
Matrix (Stuttgart, Germany) 1989;9(4):261-5.
1989: Dick Heinegård; A Oldberg
Structure and biology of cartilage and bone matrix noncollagenous macromolecules.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(9):2042-51.
1989: E Hedbom; Dick Heinegård
Interaction of a 59-kDa connective tissue matrix protein with collagen I and collagen II.
The Journal of biological chemistry 1989;264(12):6898-905.
1989: Dick Heinegård; Kjell Hultenby; A Oldberg; Finn P Reinholt; Mikael Wendel
Macromolecules in bone matrix.
Connective tissue research 1989;21(1-4):3-11; discussion 12-4.
1988: A Oldberg; A Franzén; Dick Heinegård
The primary structure of a cell-binding bone sialoprotein.
The Journal of biological chemistry 1988;263(36):19430-2.
1988: A Oldberg; A Franzén; Dick Heinegård; M Pierschbacher; E Ruoslahti
Identification of a bone sialoprotein receptor in osteosarcoma cells.
The Journal of biological chemistry 1988;263(36):19433-6.
1988: A Weiss; Erella Livne; Klaus von der Mark; Dick Heinegård; M Silbermann
Growth and repair of cartilage: organ culture system utilizing chondroprogenitor cells of condylar cartilage in newborn mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1988;3(1):93-100.
1988: Dick Heinegård; P Antonsson; E Hedbom; T Larsson; A Oldberg; Y Sommarin; Mikael Wendel
Noncollagenous matrix constituents of cartilage.
Pathology and immunopathology research 1988;7(1-2):27-31.
1987: Cecilia Rydén; I Maxe; A Franzén; A Ljungh; Dick Heinegård; Kristofer Rubin
Selective binding of bone matrix sialoprotein to Staphylococcus aureus in osteomyelitis.
Lancet 1987;2(8557):515.
1987: D Heinegård; Dick Heinegård
Isolation and characterization of proteoglycans.
Methods in enzymology 1987;144():319-72.
1987: A Franzen; Dick Heinegård; M Solursh
Evidence for sequential appearance of cartilage matrix proteins in developing mouse limbs and in cultures of mouse mesenchymal cells.
Differentiation; research in biological diversity 1987;36(3):199-210.
1987: D Heinegård; Dick Heinegård
Proteoglycans: an overview.
Methods in enzymology 1987;144():305-19.
1986: A Oldberg; A Franzén; Dick Heinegård
Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(23):8819-23.
1986: Dick Heinegård; T Larsson; Y Sommarin; A Franzén; M Paulsson; E Hedbom
Two novel matrix proteins isolated from articular cartilage show wide distributions among connective tissues.
The Journal of biological chemistry 1986;261(29):13866-72.
1986: Dick Heinegård; D Heinegård
Four classes of cell-associated proteoglycans in suspension cultures of articular-cartilage chondrocytes.
The Biochemical journal 1986;233(3):809-18.
1985: D Heinegård; J Wieslander; John K Sheehan; M Paulsson; Dick Heinegård
Separation and characterization of two populations of aggregating proteoglycans from cartilage.
The Biochemical journal 1985;225(1):95-106.
1983: Dick Heinegård; D Heinegård
Specific interaction between cartilage proteoglycans and hyaluronic acid at the chondrocyte cell surface.
The Biochemical journal 1983;214(3):777-84.
1983: M Paulsson; Dick Heinegård; D Heinegård
Metabolism of cartilage proteins in cultured tissue sections.
The Biochemical journal 1983;212(3):659-67.
1982: D Heinegård; M Paulsson; Dick Heinegård
Proteoglycans and matrix proteins in cartilage.
Progress in clinical and biological research 1982;110 Pt B():35-43.
1980: L S Lohmander; S De Luca; B Nilsson; V C Hascall; C B Caputo; J H Kimura; Dick Heinegård
Oligosaccharides on proteoglycans from the swarm rat chondrosarcoma.
The Journal of biological chemistry 1980;255(13):6084-91.
1970: N Giselson; Dick Heinegård; C G Holmberg; L G Lindberg; E Lindstedt; G Lindstedt; B Schersten
Renal medullary cystic disease or familial juvenile nephronophthisis: a renal tubular disease. Biochemical findings in two siblings.
The American journal of medicine 1970;48(2):174-84.