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Denise Carbonaro

Research Profile

Chemicals & Drugs

Procedures

Disorders

Severe Combined Immunodeficiency

Living Beings

Physiology

Transduction, Genetic

Devices

Gene Transfer Techniques

Anatomy

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Publications

TOP 3
Denise A Carbonaro; David Gjertson; Xiangyang Jin; Michael L Kaufman; Nora Rozengurt; Xiaoyan Wang; Xingchao Wang; Xiao-Jin Yu; Yang Zhou; Michael R Blackburn; Donald B Kohn
Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction.
Denise A Carbonaro; Xiangyang Jin; Daniel Cotoi; Tiejuan Mi; Xiao-Jin Yu; Dianne Skelton; Frederick Dorey; Rodney E Kellems; Michael R Blackburn; Donald B Kohn
Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion.
Barbara C Engel; Greg M Podsakoff; Joanna L Ireland; Elzbieta Monika Smogorzewska; Denise A Carbonaro; Kathy Wilson; Ami Shah; Neena Kapoor; Mirna Sweeney; Mark Borchert; Gay M Crooks; Kenneth I Weinberg; Robertson Parkman; Howard M Rosenblatt; Shi-Qi Wu; Michael S Hershfield; Fabio Candotti; Donald B Kohn
Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report.

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All Publications

2012: Denise A Carbonaro; David Gjertson; Xiangyang Jin; Michael L Kaufman; Nora Rozengurt; Xiaoyan Wang; Xingchao Wang; Xiao-Jin Yu; Yang Zhou; Michael R Blackburn; Donald B Kohn
Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction.
Blood 2012;120(18):3677-87.
2008: Denise A Carbonaro; Xiangyang Jin; Daniel Cotoi; Tiejuan Mi; Xiao-Jin Yu; Dianne Skelton; Frederick Dorey; Rodney E Kellems; Michael R Blackburn; Donald B Kohn
Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion.
Blood 2008;111(12):5745-54.
2007: Barbara C Engel; Greg M Podsakoff; Joanna L Ireland; Elzbieta Monika Smogorzewska; Denise A Carbonaro; Kathy Wilson; Ami Shah; Neena Kapoor; Mirna Sweeney; Mark Borchert; Gay M Crooks; Kenneth I Weinberg; Robertson Parkman; Howard M Rosenblatt; Shi-Qi Wu; Michael S Hershfield; Fabio Candotti; Donald B Kohn
Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report.
Blood 2007;109(2):503-6.
2006: Denise A Carbonaro; Xiangyang Jin; Denise Petersen; Xingchao Wang; Fred Dorey; Ki Soo Kil; Melissa B Aldrich; Michael R Blackburn; Rodney E Kellems; Donald B Kohn
In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(6):1110-20.
2005: Greg M Podsakoff; Barbara C Engel; Denise A Carbonaro; Chris Choi; Elzbieta Monika Smogorzewska; Gerhard Bauer; David Selander; Susan Csik; Kathy Wilson; Michael R Betts; Richard A Koup; Gary Nabel; D Keith Bishop; Steven R King; Manfred Schmidt; Christof von Kalle; Joseph A Church; Donald B Kohn
Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):77-86.
2005: Hiroshi Kobayashi; Denise A Carbonaro; Karen A Pepper; Denise Petersen; Shundi Ge; Holly Jackson; Hiroyuki Shimada; Rex Moats; Donald B Kohn
Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):776-89.
2003: Manfred Schmidt; Hanno Glimm; Manuela Wissler; Gesa Hoffmann; Karin Olsson; Stephanie Sellers; Denise A Carbonaro; John F Tisdale; Cordula Leurs; Helmut Hanenberg; Cynthia E Dunbar; Hans-Peter Kiem; Stefan Karlsson; Donald B Kohn; David Williams; Christof von Kalle
Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.
Annals of the New York Academy of Sciences 2003;996():112-21.
2003: Manfred Schmidt; Denise A Carbonaro; Carsten Speckmann; Manuela Wissler; John Bohnsack; Melissa Elder; Bruce Aronow; Jan A Nolta; Donald B Kohn; Christof von Kalle
Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates.
Nature medicine 2003;9(4):463-8.
2002: Mary A Price; Scott S Case; Denise A Carbonaro; Xiao-Jin Yu; Denise Petersen; Kathleen M Sabo; Michael Curran; Barbara C Engel; Hovanes Margarian; Janis L Abkowitz; Garry P Nolan; Donald B Kohn; Gay M Crooks
Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):645-52.
2000: Gerhard Bauer; D Selander; Barbara C Engel; Denise A Carbonaro; Susan Csik; S Rawlings; J Church; Donald B Kohn
Gene therapy for pediatric AIDS.
Annals of the New York Academy of Sciences 2000;918():318-29.
1999: Donald B Kohn; Gerhard Bauer; C R Rice; J C Rothschild; Denise A Carbonaro; P Valdez; Q l Hao; C Zhou; Ingrid Bahner; K Kearns; K Brody; S Fox; E Haden; Kathy Wilson; C Salata; C Dolan; C Wetter; E Aguilar-Cordova; J Church
A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children.
Blood 1999;94(1):368-71.
1998: Lijun Wang; PB Robbins; Denise A Carbonaro; Donald B Kohn
High-resolution analysis of cytosine methylation in the 5ĺong terminal repeat of retroviral vectors.
Human gene therapy 1998;9(16):2321-30.
1998: Donald B Kohn; Michael S Hershfield; Denise A Carbonaro; A Shigeoka; J Brooks; Elzbieta Monika Smogorzewska; Lora Barsky; R Chan; F Burotto; G Annett; Jan A Nolta; Gay M Crooks; Neena Kapoor; M Elder; Diane Wara; T Bowen; E Madsen; F F Snyder; John Bastian; Linda Muul; R. Michael Blaese; Kenneth I Weinberg; Robertson Parkman
T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates.
Nature medicine 1998;4(7):775-80.