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Jarmo Niemi

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Streptomyces

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Terhi Oja; Tatyana Sandalova; Gunter Schneider; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Laila Niiranen; Mikko Metsä-Ketelä
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Thadée Grocholski; Laurence Humphrey; Pekka Mäntsälä; Jarmo Niemi; Terhi Oja; Mikko Metsä-Ketelä
Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis.
Pekka Patrikainen; Jürgen Rohr; Khaled A Shaaban; Keqian Yang; Keqiang Fan; Pauli Kallio; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

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All Publications

2013: Terhi Oja; Tatyana Sandalova; Gunter Schneider; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Laila Niiranen; Mikko Metsä-Ketelä
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(4):1291-6.
2012: Thadée Grocholski; Laurence Humphrey; Pekka Mäntsälä; Jarmo Niemi; Terhi Oja; Mikko Metsä-Ketelä
Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis.
Journal of bacteriology 2012;194(11):2829-36.
2012: Pekka Patrikainen; Jürgen Rohr; Khaled A Shaaban; Keqian Yang; Keqiang Fan; Pauli Kallio; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.
Chemistry & biology 2012;19(5):647-55.
2012: Terhi Oja; Jari Sinkkonen; Jarmo Niemi; Laura Appassamy; Karel D Klika; Pekka Mäntsälä; Mikko Metsä-Ketelä
Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6024-9.
2011: Pauli Kallio; Pekka Mäntsälä; Mikko Metsä-Ketelä; Pekka Patrikainen; Jukka-Pekka Suomela; Jarmo Niemi
Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis.
Biochemistry 2011;50(24):5535-43.
2010: Arto Liljeblad; Pauli Kallio; Marita Vainio; Jarmo Niemi; Liisa T Kanerva
Formation and hydrolysis of amide bonds by lipase A from Candida antarctica; exceptional features.
Organic & biomolecular chemistry 2010;8(4):886-95.
2010: Thadee Grocholski; Hanna Koskiniemi; Ylva Lindqvist; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
Biochemistry 2010;49(5):934-44.
2009: Ylva Lindqvist; Hanna Koskiniemi; Anna Jansson; Tatyana Sandalova; Robert Schnell; Zhanliang Liu; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.
Journal of molecular biology 2009;393(4):966-77.
2009: Hanna Koskiniemi; Thadee Grocholski; Gunter Schneider; Jarmo Niemi
Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 3):256-9.
2008: Terhi Oja; Kaisa Palmu; Hanna Lehmussola; Outi Leppäranta; Kati Hännikäinen; Jarmo Niemi; Pekka Mäntsälä; Mikko Metsä-Ketelä
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.
Chemistry & biology 2008;15(10):1046-57.
2008: Pauli Kallio; Zhanliang Liu; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.
Chemistry & biology 2008;15(2):157-66.
2008: Pauli Kallio; Zhanliang Liu; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation.
Journal of molecular biology 2008;375(5):1212-21.
2007: Hanna Koskiniemi; Mikko Metsä-Ketelä; Doreen Dobritzsch; Pauli Kallio; Hanna Korhonen; Pekka Mäntsälä; Gunter Schneider; Jarmo Niemi
Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.
Journal of molecular biology 2007;372(3):633-48.
2007: Igor Alexeev; Azmiri Sultana; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6170-5.
2007: Azmiri Sultana; Igor Alexeev; Inari Kursula; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 2):149-59.
2006: Philipp Beinker; Bernhard Lohkamp; Taina Peltonen; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystal structures of SnoaL2 and AclR: two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics.
Journal of molecular biology 2006;359(3):728-40.
2006: Pauli Kallio; Azmiri Sultana; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Journal of molecular biology 2006;357(1):210-20.
2005: Anna Jansson; Hanna Koskiniemi; Anna Erola; Jessy Wang; Pekka Mäntsälä; Gunter Schneider; Jarmo Niemi
Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor.
The Journal of biological chemistry 2005;280(5):3636-44.
2004: Anna Jansson; Hanna Koskiniemi; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products.
The Journal of biological chemistry 2004;279(39):41149-56.
2004: Azmiri Sultana; Pauli Kallio; Anna Jansson; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1118-20.
2004: Azmiri Sultana; Pauli Kallio; Anna Jansson; Ji-Shu Wang; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.
The EMBO journal 2004;23(9):1911-21.
2003: Anna Jansson; Jarmo Niemi; Ylva Lindqvist; Pekka Mäntsälä; Gunter Schneider
Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens.
Journal of molecular biology 2003;334(2):269-80.
2003: Anna Jansson; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
The Journal of biological chemistry 2003;278(40):39006-13.
2003: Anna Jansson; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 9):1637-9.
2002: Yulong Wang; Jarmo Niemi; Pekka Mäntsälä
Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.
FEMS microbiology letters 2002;208(1):117-22.
2000: Yulong Wang; Jarmo Niemi; Kalervo Airas; Kristiina Ylihonko; Juha Hakala; Pekka Mäntsälä
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
Biochimica et biophysica acta 2000;1480(1-2):191-200.
1999: Jarmo Niemi; Yulong Wang; Kalervo Airas; Kristiina Ylihonko; Juha Hakala; Pekka Mäntsälä
Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens.
Biochimica et biophysica acta 1999;1430(1):57-64.
1995: Jarmo Niemi; Pekka Mäntsälä
Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.
Journal of bacteriology 1995;177(10):2942-5.
1994: Jarmo Niemi; Pekka Mäntsälä
TRACTOR, a program to locate subclones in a nucleotide sequence using only one sequencing reaction.
Computer applications in the biosciences : CABIOS 1994;10(5):563-6.
1994: Kristiina Ylihonko; Juha Hakala; Jarmo Niemi; J Lundell; Pekka Mäntsälä
Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants.
Microbiology (Reading, England) 1994;140 ( Pt 6)():1359-65.
1994: Jarmo Niemi; Kristiina Ylihonko; Juha Hakala; R Pärssinen; A Kopio; Pekka Mäntsälä
Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.
Microbiology (Reading, England) 1994;140 ( Pt 6)():1351-8.
1992: Miguel Angel Fernández-Moreno; A J Martín-Triana; E Martínez; Jarmo Niemi; H M Kieser; David A Hopwood; Francisco Malpartida
abaA, a new pleiotropic regulatory locus for antibiotic production in Streptomyces coelicolor.
Journal of bacteriology 1992;174(9):2958-67.
1990: Francisco Malpartida; Jarmo Niemi; R Navarrete; David A Hopwood
Cloning and expression in a heterologous host of the complete set of genes for biosynthesis of the Streptomyces coelicolor antibiotic undecylprodigiosin.
Gene 1990;93(1):91-9.