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Klein Jon

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Timothy D Cummins; Syed J Khundmiri; Klein Jon; Michelle N Lowry; MD Mendenhall; Erik A Korte; Michelle T Barati; Sarah A Salyer; David W Powell
Elongin C is a mediator of Notch4 activity in human renal tubule cells.
Michael L Merchant; Adam E Gaweda; Andrew J Dailey; Daniel W Wilkey; Xiaolan Zhang; Brad H Rovin; Klein Jon; Michael E Brier
Oncostatin M receptor β and cysteine/histidine-rich 1 are biomarkers of the response to erythropoietin in hemodialysis patients.
Timothy D Cummins; Michelle T Barati; Susan C Coventry; Sarah A Salyer; Klein Jon; David W Powell
Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.

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2011: Timothy D Cummins; Syed J Khundmiri; Klein Jon; Michelle N Lowry; MD Mendenhall; Erik A Korte; Michelle T Barati; Sarah A Salyer; David W Powell
Elongin C is a mediator of Notch4 activity in human renal tubule cells.
Biochimica et biophysica acta 2011;1814(12):1748-57.
2011: Michael L Merchant; Adam E Gaweda; Andrew J Dailey; Daniel W Wilkey; Xiaolan Zhang; Brad H Rovin; Klein Jon; Michael E Brier
Oncostatin M receptor β and cysteine/histidine-rich 1 are biomarkers of the response to erythropoietin in hemodialysis patients.
Kidney international 2011;79(5):546-54.
2010: Timothy D Cummins; Michelle T Barati; Susan C Coventry; Sarah A Salyer; Klein Jon; David W Powell
Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.
Biochimica et biophysica acta 2010;1804(4):653-61.
2010: Madhavi J Rane; Ye Song; Shunying Jin; Michelle T Barati; Rui Wu; Hina Kausar; Yi Tan; Yuehui Wang; Guihua Zhou; Klein Jon; Xiaokun Li; Lu Cai
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy.
American journal of physiology. Renal physiology 2010;298(1):F49-61.
2009: Michael L Merchant; Bruce A Perkins; Grzegorz M Boratyn; Linda H Ficociello; Daniel W Wilkey; Michelle T Barati; Clinton C Bertram; Grier P Page; Brad H Rovin; James H Warram; Andrzej S Krolewski; Klein Jon
Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria.
Journal of the American Society of Nephrology : JASN 2009;20(9):2065-74.
2009: Laurence H Beck; Ramon Bonegio; Gérard Lambeau; David M Beck; David W Powell; Timothy D Cummins; Klein Jon; David J Salant
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
The New England journal of medicine 2009;361(1):11-21.
2009: Marcus Pezzolesi; G David Poznik; Josyf C Mychaleckyj; Andrew D Paterson; Michelle T Barati; Klein Jon; Daniel P K Ng; Grzegorz Placha; Luís Henrique Canani; Jacek Bochenski; Daryl Waggott; Michael L Merchant; Bozena Krolewski; Lucia Mirea; Krzysztof Wanic; Pisut Katavetin; Masahiko Kure; Pawel Wolkow; Jonathon S Dunn; Adam Smiles; William H Walker; Andrew P Boright; Shelley B Bull; Alessandro Doria; John J Rogus; Stephen S Rich; James H Warram; Andrzej S Krolewski
Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes.
Diabetes 2009;58(6):1403-10.
2009: Cheryl Smith; Michael Merchant; Andrea Fekete; Ha-Long Nyugen; Paul Oh; You-Lin Tain; Klein Jon; Chris Baylis
Splice variants of neuronal nitric oxide synthase are present in the rat kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(5):1422-8.
2009: Tongalp H Tezel; Lijun Geng; Ewa Bodek Lato; Shlomit Schaal; Yongqing Liu; Douglas Dean; Klein Jon; Henry J Kaplan
Synthesis and secretion of hemoglobin by retinal pigment epithelium.
Investigative ophthalmology & visual science 2009;50(4):1911-9.
2009: Michael L Merchant; Klein Jon
Proteomics and diabetic retinopathy.
Clinics in laboratory medicine 2009;29(1):139-49.
2009: Madhavi J Rane; Klein Jon
Regulation of neutrophil apoptosis by modulation of PKB/Akt activation.
Frontiers in bioscience : a journal and virtual library 2009;14():2400-12.
2009: David W Powell; Clinton C Bertram; Timothy D Cummins; Michelle T Barati; Shirong Zheng; Paul N Epstein; Klein Jon
Renal tubulointerstitial fibrosis in OVE26 type 1 diabetic mice.
Nephron. Experimental nephrology 2009;111(1):e11-9.
2008: G Catapano; Klein Jon
The times they are a-changing--a year of transition.
The International journal of artificial organs 2008;31(12):997-1001.
2008: Michael L Merchant; Timothy D Cummins; Daniel W Wilkey; Sarah A Salyer; David W Powell; Klein Jon; Eleanor DeLand Lederer
Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation.
American journal of physiology. Renal physiology 2008;295(4):F1254-8.
2008: Maria P Canter; Carol A Graham; Michael H Heit; Linda S Blackwell; Daniel W Wilkey; Klein Jon; Michael L Merchant
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
American journal of obstetrics and gynecology 2008;198(5):553.e1-6.
2008: Tanea Reed; Marzia Perluigi; Rukhsana Sultana; William M Pierce; Klein Jon; Delano M Turner; Raffaella Coccia; William R Markesbery; D Allan Butterfield
Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease.
Neurobiology of disease 2008;30(1):107-20.
2008: Wycliffe O Opii; Gururaj Joshi; Elizabeth Head; Norton W Milgram; Bruce A Muggenburg; Klein Jon; William M Pierce; Carl W Cotman; D Allan Butterfield
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease.
Neurobiology of aging 2008;29(1):51-70.
2007: Michael L Merchant; Klein Jon
Proteomics and diabetic nephropathy.
Seminars in nephrology 2007;27(6):627-36.
2007: Michelle T Barati; Michael L Merchant; Angela B Kain; Anthony W Jevans; Kenneth R McLeish; Klein Jon
Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice.
American journal of physiology. Renal physiology 2007;293(4):F1157-65.
2007: C F Mello; Rukhsana Sultana; M Piroddi; Jian Cai; William M Pierce; Klein Jon; D Allan Butterfield
Acrolein induces selective protein carbonylation in synaptosomes.
Neuroscience 2007;147(3):674-9.
2007: Shelley F Newman; Rukhsana Sultana; Marzia Perluigi; Raffaella Coccia; Jian Cai; William M Pierce; Klein Jon; Delano M Turner; D Allan Butterfield
An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach.
Journal of neuroscience research 2007;85(7):1506-14.
2007: Rukhsana Sultana; Debra Boyd-Kimball; Jain Cai; William M Pierce; Klein Jon; Michael Merchant; D Allan Butterfield
Proteomics analysis of the Alzheimer's disease hippocampal proteome.
Journal of Alzheimer's disease : JAD 2007;11(2):153-64.
2007: Wycliffe O Opii; Vidya N Nukala; Rukhsana Sultana; Jignesh D Pandya; Kristen M Day; Michael Merchant; Klein Jon; Patrick G Sullivan; D Allan Butterfield
Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury.
Journal of neurotrauma 2007;24(5):772-89.
2007: Radhika A Vaishnav; Marilyn L Getchell; H Fai Poon; Kara R Barnett; Samuel A Hunter; William M Pierce; Klein Jon; D Allan Butterfield; Thomas V Getchell
Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization.
Journal of neuroscience research 2007;85(2):373-85.
2006: D Allan Butterfield; Anastazija Gnjec; H Fai Poon; Alessandra Castegna; William M Pierce; Klein Jon; Ralph N Martins
Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment.
Journal of Alzheimer's disease : JAD 2006;10(4):391-7.
2006: Yumin Chen; Chotiros Daosukho; Wycliffe O Opii; Delano M Turner; William M Pierce; Klein Jon; Mary Vore; D Allan Butterfield; Daret K St Clair
Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice.
Free radical biology & medicine 2006;41(9):1470-7.
2006: Rukhsana Sultana; Debra Boyd-Kimball; H Fai Poon; Jian Cai; William M Pierce; Klein Jon; Michael Merchant; William R Markesbery; D Allan Butterfield
Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD.
Neurobiology of aging 2006;27(11):1564-76.
2006: Debra Boyd-Kimball; H Fai Poon; Bert C Lynn; Jian Cai; William M Pierce; Klein Jon; Jmil Ferguson; Christopher D Link; D Allan Butterfield
Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's disease.
Neurobiology of aging 2006;27(9):1239-49.
2006: Rukhsana Sultana; Shelley F Newman; Hafiz Mohmmad Abdul; Jian Cai; William M Pierce; Klein Jon; Michael Merchant; D Allan Butterfield
Protective effect of D609 against amyloid-beta1-42-induced oxidative modification of neuronal proteins: redox proteomics study.
Journal of neuroscience research 2006;84(2):409-17.
2006: Allicia C Girvan; Yun Teng; Lavona K Casson; Shelia D Thomas; Simone Jüliger; Mark W Ball; Klein Jon; William M Pierce; Shirish Barve; Paula J Bates
AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.
Molecular cancer therapeutics 2006;5(7):1790-9.
2006: Michelle T Barati; Madhavi J Rane; Klein Jon; Kenneth R McLeish
A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells.
Journal of proteome research 2006;5(7):1636-46.
2006: H Fai Poon; Holly M Shepherd; Tanea T Reed; Vittorio Calabrese; Anna Maria Giuffrida Stella; Giovanni Pennisi; Jian Cai; William M Pierce; Klein Jon; D Allan Butterfield
Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis.
Neurobiology of aging 2006;27(7):1020-34.
2006: Rukhsana Sultana; Debra Boyd-Kimball; H Fai Poon; Jain Cai; William M Pierce; Klein Jon; William R Markesbery; Xiao Zhen Zhou; Kun Ping Lu; D Allan Butterfield
Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis.
Neurobiology of aging 2006;27(7):918-25.
2006: D Allan Butterfield; H Fai Poon; Daret St Clair; Jeff Keller; William M Pierce; Klein Jon; William R Markesbery
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease.
Neurobiology of disease 2006;22(2):223-32.
2006: Jyoti Krishna; Zahoor Shah; Michael Merchant; Klein Jon; David Gozal
Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findings.
Sleep medicine 2006;7(3):221-7.
2006: Rukhsana Sultana; H Fai Poon; Jian Cai; William M Pierce; Michael Merchant; Klein Jon; William R Markesbery; D Allan Butterfield
Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.
Neurobiology of disease 2006;22(1):76-87.
2006: Patrick K K Leong; Angela Devillez; Monica B Sandberg; Li E Yang; Daniel K P Yip; Klein Jon; Alicia A McDonough
Effects of ACE inhibition on proximal tubule sodium transport.
American journal of physiology. Renal physiology 2006;290(4):F854-63.
2006: Grzegorz M Boratyn; Michael L Merchant; Klein Jon
Utlization of human expert techniques for detection of low-abundant peaks in high-resolution mass spectra.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2006;1():5798-801.
2006: George Lominadze; Richard A Ward; Klein Jon; Kenneth R McLeish
Proteomic analysis of human neutrophils.
Methods in molecular biology (Clifton, N.J.) 2006;332():343-56.
2005: Michael L Merchant; Klein Jon
Proteomics and diabetic nephropathy.
Current diabetes reports 2005;5(6):464-9.
2005: Kevyn E Merten; Wenke Feng; Li Zhang; William Pierce; Jian Cai; Klein Jon; Y James Kang
Modulation of cytochrome C oxidase-va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1314-9.
2005: Marzia Perluigi; H Fai Poon; William Maragos; William M Pierce; Klein Jon; Vittorio Calabrese; Chiara Cini; Carlo De Marco; D Allan Butterfield
Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington disease.
Molecular & cellular proteomics : MCP 2005;4(12):1849-61.
2005: Klein Jon; Michelle T Barati; Rui Wu; David Gozal; Leroy R Sachleben; Hina Kausar; John O Trent; Evelyne Gozal; Madhavi J Rane
Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins.
The Journal of biological chemistry 2005;280(36):31870-81.
2005: H Fai Poon; Kenneth Hensley; Visith Thongboonkerd; Michael Merchant; Bert C Lynn; William M Pierce; Klein Jon; Vittorio Calabrese; D Allan Butterfield
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
Free radical biology & medicine 2005;39(4):453-62.
2005: H Fai Poon; Susan A Farr; William A Banks; William M Pierce; Klein Jon; john morley; D Allan Butterfield
Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein.
Brain research. Molecular brain research 2005;138(1):8-16.
2005: Madhavi J Rane; David Gozal; Waseem Butt; Evelyne Gozal; William M Pierce; Shang Z Guo; Rui Wu; Aviv D Goldbart; Visith Thongboonkerd; Kenneth R McLeish; Klein Jon
Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7242-9.
2005: Debra Boyd-Kimball; Alessandra Castegna; Rukhsana Sultana; H Fai Poon; Robin Petroze; Bert C Lynn; Klein Jon; D Allan Butterfield
Proteomic identification of proteins oxidized by Abeta(1-42) in synaptosomes: implications for Alzheimer's disease.
Brain research 2005;1044(2):206-15.
2005: Marzia Perluigi; H Fai Poon; Kenneth Hensley; William M Pierce; Klein Jon; Vittorio Calabrese; Carlo De Marco; D Allan Butterfield
Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
Free radical biology & medicine 2005;38(7):960-8.
2005: Debra Boyd-Kimball; Rukhsana Sultana; H Fai Poon; Hafiz Mohmmad-Abdul; Bert C Lynn; Klein Jon; D Allan Butterfield
Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach.
Journal of neuroscience research 2005;79(5):707-13.
2005: Chava B Pocernich; Debra Boyd-Kimball; H Fai Poon; Visith Thongboonkerd; Bert C Lynn; Klein Jon; Vittorio Calebrese; Avindra Nath; D Allan Butterfield
Proteomics analysis of human astrocytes expressing the HIV protein Tat.
Brain research. Molecular brain research 2005;133(2):307-16.
2005: Chava B Pocernich; H Fai Poon; Debra Boyd-Kimball; Bert C Lynn; Avindra Nath; Klein Jon; D Allan Butterfield
Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat.
Brain research. Molecular brain research 2005;133(2):299-306.
2005: Visith Thongboonkerd; Shirong Zheng; Kenneth R McLeish; Paul N Epstein; Klein Jon
Proteomic identification and immunolocalization of increased renal calbindin-D28k expression in OVE26 diabetic mice.
The review of diabetic studies : RDS 2005;2(1):19-26.
2005: Debra Boyd-Kimball; Rukhsana Sultana; H Fai Poon; Bert C Lynn; Fiorella Casamenti; Giancarlo Pepeu; Klein Jon; D Allan Butterfield
Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease.
Neuroscience 2005;132(2):313-24.
2005: H Fai Poon; Susan A Farr; Visith Thongboonkerd; Bert C Lynn; William A Banks; john morley; Klein Jon; D Allan Butterfield
Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders.
Neurochemistry international 2005;46(2):159-68.
2004: Xia Shen; Shirong Zheng; Visith Thongboonkerd; Ming Xu; William M Pierce; Klein Jon; Paul N Epstein
Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes.
American journal of physiology. Endocrinology and metabolism 2004;287(5):E896-905.
2004: Visith Thongboonkerd; Michelle T Barati; Kenneth R McLeish; Charaf Benarafa; Eileen Remold-O'Donnell; Shirong Zheng; Brad H Rovin; William M Pierce; Paul N Epstein; Klein Jon
Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis.
Journal of the American Society of Nephrology : JASN 2004;15(3):650-62.
2004: Ganesh Kumar; Klein Jon
Analysis of expression and posttranslational modification of proteins during hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(3):1178-86; discussion 1170-2.
2004: H Fai Poon; Alessandra Castegna; Susan A Farr; Visith Thongboonkerd; Bert C Lynn; W A Banks; J E Morley; Klein Jon; D Allan Butterfield
Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain.
Neuroscience 2004;126(4):915-26.
2004: Visith Thongboonkerd; Klein Jon; Anthony W Jevans; Kenneth R McLeish
Urinary proteomics and biomarker discovery for glomerular diseases.
Contributions to nephrology 2004;141():292-307.
2004: Visith Thongboonkerd; Klein Jon
Proteomics and hypertension.
Contributions to nephrology 2004;141():245-56.
2004: Visith Thongboonkerd; Michelle T Barati; Kenneth R McLeish; William M Pierce; Paul N Epstein; Klein Jon
Proteomics and diabetic nephropathy.
Contributions to nephrology 2004;141():142-54.
2004: Visith Thongboonkerd; Klein Jon
Practical bioinformatics for proteomics.
Contributions to nephrology 2004;141():79-92.
2004: Elias Klein; Klein Jon; Visith Thongboonkerd
Two-dimensional gel electrophoresis: a fundamental tool for expression proteomics studies.
Contributions to nephrology 2004;141():25-39.
2004: Visith Thongboonkerd; Elias Klein; Klein Jon
Sample preparation for 2-D proteomic analysis.
Contributions to nephrology 2004;141():11-24.
2004: Klein Jon; Visith Thongboonkerd
Overview of proteomics.
Contributions to nephrology 2004;141():1-10.
2003: Michael E Brier; Prasun C Ray; Klein Jon
Prediction of delayed renal allograft function using an artificial neural network.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(12):2655-9.
2003: Saurabh Singh; David W Powell; Madhavi J Rane; Thomas H Millard; John O Trent; William M Pierce; Klein Jon; Laura M Machesky; Kenneth R McLeish
Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
The Journal of biological chemistry 2003;278(38):36410-7.
2003: Shelley X L Zhang; David Gozal; Leroy R Sachleben; Madhavi J Rane; Klein Jon; Evelyne Gozal
Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1709-11.
2003: David W Powell; Madhavi J Rane; Brian A Joughin; Ralitsa Kalmukova; Jeong-Ho Hong; Bruce Tidor; William L Dean; William M Pierce; Klein Jon; Michael B Yaffe; Kenneth R McLeish
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
Molecular and cellular biology 2003;23(15):5376-87.
2003: Madhavi J Rane; Yong Pan; Saurabh Singh; David W Powell; Rui Wu; Timothy Cummins; Qingdan Chen; Kenneth R McLeish; Klein Jon
Heat shock protein 27 controls apoptosis by regulating Akt activation.
The Journal of biological chemistry 2003;278(30):27828-35.
2003: Klein Jon; David Gozal; William M Pierce; Visith Thongboonkerd; Janice A Scherzer; Leroy R Sachleben; Shang Z Guo; Jian Cai; Evelyne Gozal
Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia.
Respiratory physiology & neurobiology 2003;136(2-3):91-103.
2003: Alessandra Castegna; Visith Thongboonkerd; Klein Jon; Bert C Lynn; William R Markesbery; D Allan Butterfield
Proteomic identification of nitrated proteins in Alzheimer's disease brain.
Journal of neurochemistry 2003;85(6):1394-401.
2003: Visith Thongboonkerd; Klein Jon; William M Pierce; Anthony W Jevans; John M Arthur
Sodium loading changes urinary protein excretion: a proteomic analysis.
American journal of physiology. Renal physiology 2003;284(6):F1155-63.
2003: Qingdan Chen; David W Powell; Madhavi J Rane; Saurabh Singh; Waseem Butt; Klein Jon; Kenneth R McLeish
Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5302-8.
2003: Visith Thongboonkerd; Klein Jon; John M Arthur
Proteomic identification of a large complement of rat urinary proteins.
Nephron. Experimental nephrology 2003;95(2):e69-78.
2002: Evelyne Gozal; David Gozal; William M Pierce; Visith Thongboonkerd; Janice A Scherzer; Leroy R Sachleben; Kenneth R Brittian; Shang Z Guo; Jian Cai; Klein Jon
Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia.
Journal of neurochemistry 2002;83(2):331-45.
2002: Visith Thongboonkerd; Kenneth R McLeish; John M Arthur; Klein Jon
Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation.
Kidney international 2002;62(4):1461-9.
2002: John M Arthur; Visith Thongboonkerd; Janice A Scherzer; Jian Cai; William M Pierce; Klein Jon
Differential expression of proteins in renal cortex and medulla: a proteomic approach.
Kidney international 2002;62(4):1314-21.
2002: Visith Thongboonkerd; Evelyne Gozal; Leroy R Sachleben; John M Arthur; William M Pierce; Jian Cai; Julie Chao; Michael Bader; João B Pesquero; David Gozal; Klein Jon
Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension.
The Journal of biological chemistry 2002;277(38):34708-16.
2002: Alessandra Castegna; Michael Y Aksenov; Visith Thongboonkerd; Klein Jon; William M Pierce; Rosemarie M Booze; William R Markesbery; D Allan Butterfield
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.
Journal of neurochemistry 2002;82(6):1524-32.
2002: Alessandra Castegna; Michael Y Aksenov; Marina V Aksenova; Visith Thongboonkerd; Klein Jon; William M Pierce; Rosemarie M Booze; William R Markesbery; D Allan Butterfield
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
Free radical biology & medicine 2002;33(4):562-71.
2002: Ralph Kettritz; Mira Choi; Waseem Butt; Madhavi J Rane; Susanne Rolle; Friedrich C Luft; Klein Jon
Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils.
Journal of the American Society of Nephrology : JASN 2002;13(7):1740-9.
2002: Robert E Molestina; Klein Jon; Richard D Miller; William H Pierce; Julio A Ramirez; James T Summersgill
Proteomic analysis of differentially expressed Chlamydia pneumoniae genes during persistent infection of HEp-2 cells.
Infection and immunity 2002;70(6):2976-81.
2002: Visith Thongboonkerd; Jirapon Luengpailin; Junkai Cao; William M Pierce; Jian Cai; Klein Jon; Ronald J Doyle
Fluoride exposure attenuates expression of Streptococcus pyogenes virulence factors.
The Journal of biological chemistry 2002;277(19):16599-605.
2002: Changxu Song; Thomas M Vondriska; Guang-Wu Wang; Klein Jon; Xinan Cao; Jun Zhang; Y James Kang; Stanley D'Souza; Peipei Ping
Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase.
American journal of physiology. Heart and circulatory physiology 2002;282(3):H1166-71.
2002: Klein Jon; Guang-Wu Wang; Zhanxiang Zhou; Abdul Buridi; Y James Kang
Inhibition of tumor necrosis factor-alpha-dependent cardiomyocyte apoptosis by metallothionein.
Cardiovascular toxicology 2002;2(3):209-18.
2001: Guang-Wu Wang; Klein Jon; Y James Kang
Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes.
The Journal of pharmacology and experimental therapeutics 2001;298(2):461-8.
2001: Klein Jon; Abdul Buridi; Patricia Y Coxon; Madhavi J Rane; T Manning; R Kettritz; Kenneth R McLeish
Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.
Cellular signalling 2001;13(5):335-43.
2001: Guang-Wu Wang; Zhanxiang Zhou; Klein Jon; Y James Kang
Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2001;280(5):H2292-9.
2001: Thomas M Vondriska; Klein Jon; Peipei Ping
Use of functional proteomics to investigate PKC epsilon-mediated cardioprotection: the signaling module hypothesis.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1434-41.
2001: Madhavi J Rane; Patricia Y Coxon; David W Powell; R Webster; Klein Jon; William Pierce; Peipei Ping; Kenneth R McLeish
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils.
The Journal of biological chemistry 2001;276(5):3517-23.
2000: Lu Cai; Klein Jon; Y James Kang
Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage.
The Journal of biological chemistry 2000;275(50):38957-60.
2000: Ralph Kettritz; Y X Xu; B Faass; Klein Jon; E C Müller; A Otto; Andreas Busjahn; F C Luft; Hermann Haller
TNF-alpha-mediated neutrophil apoptosis involves Ly-GDI, a Rho GTPase regulator.
Journal of leukocyte biology 2000;68(2):277-83.
2000: Patricia Y Coxon; Madhavi J Rane; David W Powell; Klein Jon; Kenneth R McLeish
Differential mitogen-activated protein kinase stimulation by Fc gamma receptor IIa and Fc gamma receptor IIIb determines the activation phenotype of human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6530-7.
2000: Y James Kang; Z X Zhou; Guang-Wu Wang; Abdul Buridi; Klein Jon
Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases.
The Journal of biological chemistry 2000;275(18):13690-8.
2000: Y James Kang; Z X Zhou; H Wu; Guang-Wu Wang; Jack T Saari; Klein Jon
Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide.
Laboratory investigation; a journal of technical methods and pathology 2000;80(5):745-57.
2000: Klein Jon; Madhavi J Rane; Janice A Scherzer; Patricia Y Coxon; R Kettritz; J M Mathiesen; Abdul Buridi; Kenneth R McLeish
Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4286-91.
2000: Milind Shrotri; JF Kuhn; James C Peyton; HJ Flodgaard; Klein Jon; William G Cheadle
Heparin-binding protein decreases apoptosis in human and murine neutrophils.
The Journal of surgical research 2000;89(1):53-9.
1999: Klein Jon; Kenneth R McLeish; Richard A Ward
Transplantation, not dialysis, corrects azotemia-dependent priming of the neutrophil oxidative burst.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;33(3):483-91.
1999: R Kettritz; Y X Xu; T Kerren; P Quass; Klein Jon; F C Luft; H Haller
Extracellular matrix regulates apoptosis in human neutrophils.
Kidney international 1999;55(2):562-71.
1998: Kenneth R McLeish; Klein Jon; Patricia Y Coxon; K Z Head; Richard A Ward
Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils.
Journal of leukocyte biology 1998;64(6):835-44.
1998: Kenneth R McLeish; C Knall; Richard A Ward; P Gerwins; Patricia Y Coxon; Klein Jon; Gary L Johnson
Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF.
Journal of leukocyte biology 1998;64(4):537-45.
1998: Eleanor Lederer; SS Sohi; J M Mathiesen; Klein Jon
Regulation of expression of type II sodium-phosphate cotransporters by protein kinases A and C.
The American journal of physiology 1998;275(2 Pt 2):F270-7.
1997: Madhavi J Rane; S L Carrithers; John M Arthur; Klein Jon; Kenneth R McLeish
Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):5070-8.
1997: Mark D Pescovitz; G Barone; MG Choc; D E Hricik; D S Hwang; J H Jin; Klein Jon; C L Marsh; D I Min; Raymond Pollak; Timothy L Pruett; J B Stinson; J S Thompson; Eva M Vasquez; T Waid; D G Wombolt; RL Wong
Safety and tolerability of cyclosporine microemulsion versus cyclosporine: two-year data in primary renal allograft recipients: a report of the Neoral Study Group.
Transplantation 1997;63(5):778-80.
1997: Janice A Scherzer; Y Lin; Kenneth R McLeish; Klein Jon
TNF translationally modulates the expression of G1 protein alpha(i2) subunits in human polymorphonuclear leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):913-8.
1996: Kenneth R McLeish; Klein Jon; Eleanor Lederer; K Z Head; Richard A Ward
Azotemia, TNF alpha, and LPS prime the human neutrophil oxidative burst by distinct mechanisms.
Kidney international 1996;50(2):407-16.
1996: G Barone; C M Bunke; MG Choc; D E Hricik; J H Jin; Klein Jon; C L Marsh; D I Min; M D Pescovitz; R Pollak; Timothy L Pruett; J B Stinson; J S Thompson; E Vasquez; T Waid; D G Wombolt; RL Wong
Safety and tolerability of Neoral vs Sandimmune: 1-year data in primary renal allograft recipients. Neoral Study Group.
Transplantation proceedings 1996;28(4):2183-6.
1996: G Barone; C M Bunke; MG Choc; D E Hricik; J H Jin; Klein Jon; C L Marsh; D I Min; M D Pescovitz; R Pollak; Timothy L Pruett; J B Stinson; J S Thompson; E Vasquez; T Waid; D G Wombolt; RL Wong
The safety and tolerability of cyclosporine emulsion versus cyclosporine in a randomized, double-blind comparison in primary renal allograft recipients. The Neoral Study Group.
Transplantation 1996;61(6):968-70.
1996: G Barone; C T Chang; MG Choc; Klein Jon; C L Marsh; J A Meligeni; D I Min; M D Pescovitz; R Pollak; Timothy L Pruett; J B Stinson; J S Thompson; E Vasquez; T Waid; D G Wombolt; RL Wong
The pharmacokinetics of a microemulsion formulation of cyclosporine in primary renal allograft recipients. The Neoral Study Group.
Transplantation 1996;61(6):875-80.
1995: A A Jacobs; J L Huber; Richard A Ward; Klein Jon; Kenneth R McLeish
Chemoattractant receptor-specific differences in G protein activation rates regulate effector enzyme and functional responses.
Journal of leukocyte biology 1995;57(4):679-86.
1995: Klein Jon; J A Scherzer; G Harding; A A Jacobs; Kenneth R McLeish
TNF-alpha stimulates increased plasma membrane guanine nucleotide binding protein activity in polymorphonuclear leukocytes.
Journal of leukocyte biology 1995;57(3):500-6.
1994: Kenneth R McLeish; Eleanor Lederer; Klein Jon; J L Hoffman
Effect of prenylcysteine analogues on chemoattractant receptor-mediated G protein activation.
Cellular signalling 1994;6(5):569-79.
1994: ES Miller; D A Koebel; S A Davis; Klein Jon; Kenneth R McLeish; D Goldwater; Gerald Sonnenfeld
Influence of suspension on the oxidative burst by rat neutrophils.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(1):387-90.
1993: Kenneth R McLeish; Eleanor Lederer; Klein Jon
Role of isoprenoid metabolism in chemotactic peptide receptor-mediated G protein activation.
Biochemical and biophysical research communications 1993;197(2):763-70.
1993: M Bunke; B Ganzel; Klein Jon; J Oldfather
The effect of a positive B cell crossmatch on early rejection in cardiac transplant recipients.
Transplantation 1993;56(6):1595-7.
1993: AD Slater; Klein Jon; C W Czarniecki; Gerald Sonnenfeld
The effect of interferon-gamma on rejection and neutrophil function following transplantation.
Journal of interferon research 1993;13(5):359-62.
1993: K Erbeck; Klein Jon; Kenneth R McLeish
Differential uncoupling of chemoattractant receptors from G proteins in retinoic acid-differentiated HL-60 granulocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(5):1913-21.
1993: Klein Jon
Immunologic renal injury.
Current opinion in nephrology and hypertension 1993;2(2):225-30.
1993: MK Tanner; S R Wellhausen; Klein Jon
Flow cytometric analysis of altered mononuclear cell transmembrane potential induced by cyclosporin.
Cytometry 1993;14(1):59-69.
1993: Anthony Atala; G S Steinbock; J I Harty; Klein Jon
Extracorporeal shock-wave lithotripsy in transplanted kidney.
Urology 1993;41(1):60-2.
1992: AD Slater; Klein Jon; G Sonnenfeld; L L Ogden; Laman A Gray
The effects of interferon-alpha/beta in a model of rat heart transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1992;11(5):975-8.
1992: T M Schepers; Klein Jon; P W Feldhoff; W L Dean; Kenneth R McLeish
Interferon-gamma induces phosphorylation of multiple small-molecular-weight proteins in U937 cells.
Journal of interferon research 1992;12(4):289-96.
1992: Klein Jon; J A Scherzer; Kenneth R McLeish
IFN-gamma enhances expression of formyl peptide receptors and guanine nucleotide-binding proteins by HL-60 granulocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2483-8.
1991: Kenneth R McLeish; Klein Jon; T Schepers; Gerald Sonnenfeld
Modulation of transmembrane signalling in HL-60 granulocytes by tumour necrosis factor-alpha.
The Biochemical journal 1991;279 ( Pt 2)():455-60.
1991: Klein Jon; Gerald Sonnenfeld; Kenneth R McLeish
Priming of the HL-60 cell respiratory burst response by tumor necrosis factor-alpha.
Lymphokine and cytokine research 1991;10(3):173-6.
1991: Klein Jon; J A Scherzer; Kenneth R McLeish
Interferon-gamma enhances superoxide production by HL-60 cells stimulated with multiple agonists.
Journal of interferon research 1991;11(2):69-74.
1991: A G Duncan; J B Richardson; Klein Jon; I N Targoff; T M Woodcock; Jeffrey P Callen
Clinical, serologic, and immunogenetic studies in patients with dermatomyositis.
Acta dermato-venereologica 1991;71(4):312-6.
1990: Klein Jon; V Payne; T M Schepers; Kenneth R McLeish
Bacterial lipopolysaccharide enhances polymorphonuclear leukocyte function independent of changes in intracellular calcium.
Inflammation 1990;14(5):599-611.
1990: Klein Jon; T M Schepers; W L Dean; Gerald Sonnenfeld; Kenneth R McLeish
Role of intracellular calcium concentration and protein kinase C activation in IFN-gamma stimulation of U937 cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(11):4305-11.
1989: T M Ganzel; J Brohm; C M Nechtman; B L Ganzel; Klein Jon; Laman A Gray
Otolaryngologic problems in cardiac transplant patients.
The Laryngoscope 1989;99(2):158-61.
1988: C Mavroudis; H Harrison; Klein Jon; Laman A Gray; B L Ganzel; S R Wellhausen; F Elbl; Larry N Cook
Infant orthotopic cardiac transplantation.
The Journal of thoracic and cardiovascular surgery 1988;96(6):912-24.
1988: L R Klein; Klein Jon; R Hanno; Jeffrey P Callen
Cutaneous mast cell quantity in pruritic and nonpruritic hemodialysis patients.
International journal of dermatology 1988;27(8):557-9.
1988: Klein Jon; Kenneth R McLeish; C M Bunke; B Chang; B L Ganzel; AD Slater; Laman A Gray
Use of OKT3 monoclonal antibody in the treatment of acute cardiac allograft rejection.
Transplantation 1988;45(4):727-9.
1988: C R Spann; Jeffrey P Callen; Klein Jon; K B Kulick
Clinical, serologic and immunogenetic studies in patients with chronic cutaneous (discoid) lupus erythematosus who have verrucous and/or hypertrophic skin lesions.
The Journal of rheumatology 1988;15(2):256-61.
1987: Klein Jon; Kenneth R McLeish; G Sonnenfeld; W L Dean
Potential mechanisms of cytosolic calcium modulation in interferon-gamma treated U937 cells.
Biochemical and biophysical research communications 1987;145(3):1295-30.
1987: Laman A Gray; AD Slater; Klein Jon
A successful cardiac transplantation program using combined university and community resources.
Annals of surgery 1987;205(6):719-26.
1987: AD Slater; Klein Jon; Laman A Gray
Clinical orthotopic cardiac transplantation.
American journal of surgery 1987;153(6):582-93.