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raymond bartus

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raymond bartus; Tiffany L Baumann; Lamar Brown; Brian R Kruegel; Jeffrey M Ostrove; Christopher D Herzog
Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating "clinical proof-of-concept" for AAV-neurturin (CERE-120) in Parkinson's disease.
William J Marks; raymond bartus; Joao Siffert; Charles S Davis; Andres Lozano; Nicholas Boulis; Jerrold L Vitek; Mark Stacy; Dennis Turner; Leonard Verhagen; Roy A E Bakay; Ray L Watts; Barton Guthrie; Joseph Jankovic; Richard Simpson; Michele Tagliati; Ron Alterman; Matthew Stern; Gordon Baltuch; Philip A Starr; Paul S Larson; Jill L Ostrem; John G Nutt; Karl Kieburtz; Jeffrey Kordower; C Warren Olanow
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
Wei Zhu; Yongfeng Fan; Qi Hao; Fanxia Shen; Tomoki Hashimoto; Guo-Yuan Yang; Mehdi Gasmi; raymond bartus; William L Young; Yongmei Chen
Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke.

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All Publications

2013: raymond bartus; Tiffany L Baumann; Lamar Brown; Brian R Kruegel; Jeffrey M Ostrove; Christopher D Herzog
Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating "clinical proof-of-concept" for AAV-neurturin (CERE-120) in Parkinson's disease.
Neurobiology of aging 2013;34(1):35-61.
2010: William J Marks; raymond bartus; Joao Siffert; Charles S Davis; Andres Lozano; Nicholas Boulis; Jerrold L Vitek; Mark Stacy; Dennis Turner; Leonard Verhagen; Roy A E Bakay; Ray L Watts; Barton Guthrie; Joseph Jankovic; Richard Simpson; Michele Tagliati; Ron Alterman; Matthew Stern; Gordon Baltuch; Philip A Starr; Paul S Larson; Jill L Ostrem; John G Nutt; Karl Kieburtz; Jeffrey Kordower; C Warren Olanow
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
Lancet neurology 2010;9(12):1164-72.
2009: Wei Zhu; Yongfeng Fan; Qi Hao; Fanxia Shen; Tomoki Hashimoto; Guo-Yuan Yang; Mehdi Gasmi; raymond bartus; William L Young; Yongmei Chen
Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(9):1528-37.
2009: Christopher D Herzog; Lamar Brown; Dawn Gammon; Brian Kruegel; Richard Lin; Alistair Wilson; Ariadne Bolton; Marie Printz; Mehdi Gasmi; Kathie M Bishop; Jeffrey Kordower; raymond bartus
Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease.
Neurosurgery 2009;64(4):602-12; discussion 612-3.
2009: Shilpa Ramaswamy; Jodi L McBride; Ina Han; Elizabeth M Berry-Kravis; Lili Zhou; Christopher D Herzog; Mehdi Gasmi; raymond bartus; Jeffrey Kordower
Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease.
Neurobiology of disease 2009;34(1):40-50.
2009: Colin K Franz; Thais Federici; Jun Yang; Carey Backus; Sang Su Oh; Qingshan Teng; Erin Carlton; Kathie M Bishop; Mehdi Gasmi; raymond bartus; Eva L Feldman; Nicholas M Boulis
Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS.
Neurobiology of disease 2009;33(3):473-81.
2009: raymond bartus; Reginald L Dean
Pharmaceutical treatment for cognitive deficits in Alzheimer's disease and other neurodegenerative conditions: exploring new territory using traditional tools and established maps.
Psychopharmacology 2009;202(1-3):15-36.
2008: Christopher D Herzog; Biplob Dass; Mehdi Gasmi; Roy A E Bakay; James E Stansell; Mark H Tuszynski; Krystof Bankiewicz; Er-Yun Chen; Yaping Chu; Kathie Bishop; Jeffrey Kordower; raymond bartus
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(10):1737-44.
2008: Kathie M Bishop; Eva K Hofer; Arpesh Mehta; Anthony Ramirez; Liangwu Sun; Mark H Tuszynski; raymond bartus
Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons.
Experimental neurology 2008;211(2):574-84.
2008: William J Marks; Jill L Ostrem; Leonard Verhagen; Philip A Starr; Paul S Larson; Roy A E Bakay; Robin Taylor; Deborah A Cahn-Weiner; A Jon Stoessl; C Warren Olanow; raymond bartus
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial.
Lancet neurology 2008;7(5):400-8.
2008: Wei Zhu; Yongfeng Fan; Tim Frenzel; Mehdi Gasmi; raymond bartus; William L Young; Guo-Yuan Yang; Yongmei Chen
Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice.
Stroke; a journal of cerebral circulation 2008;39(4):1254-61.
2007: Angelo C Lepore; Christine Haenggeli; Mehdi Gasmi; Kathie M Bishop; raymond bartus; Nicholas J Maragakis; Jeffrey rothstein
Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS.
Brain research 2007;1185():256-65.
2007: Mehdi Gasmi; Eugene Brandon; Christopher D Herzog; Alistair Wilson; Kathie M Bishop; Eva K Hofer; Justine J Cunningham; Marie A Printz; Jeffrey Kordower; raymond bartus
AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease.
Neurobiology of disease 2007;27(1):67-76.
2007: Christopher D Herzog; Biplob Dass; James E Holden; James Stansell; Mehdi Gasmi; Mark H Tuszynski; raymond bartus; Jeffrey Kordower
Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys.
Movement disorders : official journal of the Movement Disorder Society 2007;22(8):1124-32.
2007: Shilpa Ramaswamy; Jodi L McBride; Christopher D Herzog; Eugene Brandon; Mehdi Gasmi; raymond bartus; Jeffrey Kordower
Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Neurobiology of disease 2007;26(2):375-84.
2007: raymond bartus; Christopher D Herzog; Kathie Bishop; Jeffrey M Ostrove; Mark H Tuszynski; Jeffrey Kordower; Mehdi Gasmi
Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point.
Parkinsonism & related disorders 2007;13 Suppl 3():S469-77.
2007: Mehdi Gasmi; Christopher D Herzog; Eugene Brandon; Justine J Cunningham; G Anthony Ramirez; Elias T Ketchum; raymond bartus
Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):62-8.
2006: Jeffrey Kordower; Christopher D Herzog; Biplob Dass; Roy A E Bakay; James Stansell; Mehdi Gasmi; raymond bartus
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
Annals of neurology 2006;60(6):706-15.
2006: Jodi L McBride; Shilpa Ramaswamy; Mehdi Gasmi; raymond bartus; Christopher D Herzog; Eugene Brandon; Lili Zhou; Mark R Pitzer; Elizabeth M Berry-Kravis; Jeffrey Kordower
Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9345-50.
2004: raymond bartus; Dwaine F Emerich; Pam Snodgrass-Belt; Karen Fu; Heather Salzberg-Brenhouse; Denise Lafreniere; Leah Novak; Ee-Sing Lo; Thomas Cooper; Anthony Basile
A pulmonary formulation of L-dopa enhances its effectiveness in a rat model of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 2004;310(2):828-35.
2003: raymond bartus; Dwaine F Emerich; Joyce Hotz; Marc Blaustein; Reginald L Dean; Brigido Perdomo; Anthony Basile
Vivitrex, an injectable, extended-release formulation of naltrexone, provides pharmacokinetic and pharmacodynamic evidence of efficacy for 1 month in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):1973-82.
2003: Heather C Salzberg-Brenhouse; Er-Yun Chen; Dwaine F Emerich; Sam Baldwin; Ken Hogeland; Sharon Ranelli; Denise Lafreniere; Brigido Perdomo; Leah Novak; Theodora Kladis; Karen Fu; Anthony Basile; Jeffrey Kordower; raymond bartus
Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration.
The Journal of pharmacology and experimental therapeutics 2003;306(1):218-28.
2002: Cesario Borlongan; Dwaine F Emerich; Barry Hoffer; raymond bartus
Bradykinin receptor agonist facilitates low-dose cyclosporine-A protection against 6-hydroxydopamine neurotoxicity.
Brain research 2002;956(2):211-20.
2002: Dwaine F Emerich; Pamela Snodgrass; Denise Lafreniere; Reginald L Dean; Heather Salzberg; Joanne Marsh; Brigido Perdomo; Mahin Arastu; Shelley R Winn; raymond bartus
Sustained release chemotherapeutic microspheres provide superior efficacy over systemic therapy and local bolus infusions.
Pharmaceutical research 2002;19(7):1052-60.
2002: Rolf F Barth; Weilian Yang; raymond bartus; Joan H. Rotaru; Amy K Ferketich; Melvin L Moeschberger; Marta M Nawrocky; Jeffrey A Coderre; Einar K Rofstad
Neutron capture therapy of intracerebral melanoma: enhanced survival and cure after blood-brain barrier opening to improve delivery of boronophenylalanine.
International journal of radiation oncology, biology, physics 2002;52(3):858-68.
2002: Dwaine F Emerich; Shelley R Winn; raymond bartus
Injection of chemotherapeutic microspheres and glioma. IV: Eradicating tumors in rats.
Cell transplantation 2002;11(1):47-54.
2002: Dwaine F Emerich; Shelley R Winn; raymond bartus
Injection of chemotherapeutic microspheres and glioma. III: Parameters to optimize efficacy.
Cell transplantation 2002;11(1):35-45.
2002: Dwaine F Emerich; Reginald L Dean; raymond bartus
The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?
Experimental neurology 2002;173(1):168-81.
2001: Dwaine F Emerich; Reginald L Dean; Pamela Snodgrass; Denise Lafreniere; M Agostino; T Wiens; H Xiong; BP Hasler; Joanne Marsh; M Pink; BS Kim; Brigido Perdomo; raymond bartus
Bradykinin modulation of tumor vasculature: II. activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors.
The Journal of pharmacology and experimental therapeutics 2001;296(2):632-41.
2001: Dwaine F Emerich; Pamela Snodgrass; Reginald L Dean; Denise Lafreniere; M Agostino; T Wiens; H Xiong; BP Hasler; Joanne Marsh; M Pink; BS Kim; raymond bartus
Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy.
The Journal of pharmacology and experimental therapeutics 2001;296(2):623-31.
2001: Dwaine F Emerich; Reginald L Dean; C Osborn; raymond bartus
The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier: from concept to clinical evaluation.
Clinical pharmacokinetics 2001;40(2):105-23.
2000: Er-Yun Chen; DF Emerich; raymond bartus; Jeffrey Kordower
B2 bradykinin receptor immunoreactivity in rat brain.
The Journal of comparative neurology 2000;427(1):1-18.
2000: Dwaine F Emerich; Reginald L Dean; Joanne Marsh; M Pink; Denise Lafreniere; Pamela Snodgrass; raymond bartus
Intravenous cereport (RMP-7) enhances delivery of hydrophilic chemotherapeutics and increases survival in rats with metastatic tumors in the brain.
Pharmaceutical research 2000;17(10):1212-9.
2000: Dwaine F Emerich; Shelley R Winn; Pamela Snodgrass; Denise Lafreniere; M Agostino; T Wiens; H Xiong; raymond bartus
Injectable chemotherapeutic microspheres and glioma II: enhanced survival following implantation into deep inoperable tumors.
Pharmaceutical research 2000;17(7):776-81.
2000: Dwaine F Emerich; Shelley R Winn; Y Hu; Joanne Marsh; Pamela Snodgrass; Denise Lafreniere; T Wiens; BP Hasler; raymond bartus
Injectable chemotherapeutic microspheres and glioma I: enhanced survival following implantation into the cavity wall of debulked tumors.
Pharmaceutical research 2000;17(7):767-75.
2000: Weilian Yang; Rolf F Barth; raymond bartus; Joan H. Rotaru; Melvin L Moeschberger; Amy K Ferketich; Marta M Nawrocky; Jeffrey A Coderre; JH Goodman
Improved survival after boron neutron capture therapy of brain tumors by Cereport-mediated blood-brain barrier modulation to enhance delivery of boronophenylalanine.
Neurosurgery 2000;47(1):189-97; discussion 197-8.
2000: raymond bartus; Pamela Snodgrass; Joanne Marsh; M Agostino; A Perkins; Dwaine F Emerich
Intravenous cereport (RMP-7) modifies topographic uptake profile of carboplatin within rat glioma and brain surrounding tumor, elevates platinum levels, and enhances survival.
The Journal of pharmacology and experimental therapeutics 2000;293(3):903-11.
2000: raymond bartus
On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis.
Experimental neurology 2000;163(2):495-529.
2000: raymond bartus; Pamela Snodgrass; Reginald L Dean; Jeffrey Kordower; Dwaine F Emerich
Evidence that Cereport's ability to increase permeability of rat gliomas is dependent upon extent of tumor growth: implications for treating newly emerging tumor colonies.
Experimental neurology 2000;161(1):234-44.
2000: Kathryn E Saatman; Chen Zhang; raymond bartus; Tracy K McIntosh
Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(1):66-73.
1999: raymond bartus; D F Emerich
Cholinergic markers in Alzheimer disease.
JAMA : the journal of the American Medical Association 1999;282(23):2208-9.
1999: David H Overstreet; Alexey B Kampov-Polevoy; Amir H Rezvani; C Braun; raymond bartus; Fulton T Crews
Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding.
Alcoholism, clinical and experimental research 1999;23(11):1761-71.
1999: Reginald L Dean; Dwaine F Emerich; BP Hasler; raymond bartus
Cereport (RMP-7) increases carboplatin levels in brain tumors after pretreatment with dexamethasone.
Neuro-oncology 1999;1(4):268-74.
1999: Jasmina B Mackic; Monique F Stins; S Jovanovic; Kwang S Kim; raymond bartus; Berislav V Zlokovic
Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers.
Pharmaceutical research 1999;16(9):1360-5.
1999: Keiro Ikeda; Tomotsugu Ichikawa; Hiroaki Wakimoto; JS Silver; Thomas S Deisboeck; D Finkelstein; Griffith R Harsh; David N Louis; raymond bartus; Fred H Hochberg; E Antonio Chiocca
Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses.
Nature medicine 1999;5(8):881-7.
1999: Dwaine F Emerich; Pamela Snodgrass; R Dean; M Agostino; BP Hasler; M Pink; H Xiong; BS Kim; raymond bartus
Enhanced delivery of carboplatin into brain tumours with intravenous Cereport (RMP-7): dramatic differences and insight gained from dosing parameters.
British journal of cancer 1999;80(7):964-70.
1999: raymond bartus
The blood-brain barrier as a target for pharmacological modulation.
Current opinion in drug discovery & development 1999;2(2):152-67.
1999: raymond bartus; E Y Chen; G Lynch; Jeffrey Kordower
Cortical ablation induces a spreading calcium-dependent, secondary pathogenesis which can be reduced by inhibiting calpain.
Experimental neurology 1999;155(2):315-26.
1999: Rolf F Barth; Weilian Yang; raymond bartus; Melvin L Moeschberger; JH Goodman
Enhanced delivery of boronophenylalanine for neutron capture therapy of brain tumors using the bradykinin analog Cereport (Receptor-Mediated Permeabilizer-7).
Neurosurgery 1999;44(2):351-9; discussion 359-60.
1999: D F Emerich; M A Tracy; K L Ward; M Figueiredo; R Qian; C Henschel; raymond bartus
Biocompatibility of poly (DL-lactide-co-glycolide) microspheres implanted into the brain.
Cell transplantation 1999;8(1):47-58.
1998: raymond bartus; Mark A Tracy; D F Emerich; Stephen E Zale
Sustained delivery of proteins for novel therapeutic agents.
Science (New York, N.Y.) 1998;281(5380):1161-2.
1998: Dwaine F Emerich; Pamela Snodgrass; M Pink; F Bloom; raymond bartus
Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport (RMP-7).
Brain research 1998;801(1-2):259-66.
1998: Daniel R LeMay; M Kittaka; Erlinda M Gordon; B Gray; Monique F Stins; J Gordon McComb; S Jovanovic; P Tabrizi; Martin H Weiss; raymond bartus; W French Anderson; Berislav V Zlokovic
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy.
Human gene therapy 1998;9(7):989-95.
1998: raymond bartus; Reginald L Dean; S Mennerick; D Eveleth; G Lynch
Temporal ordering of pathogenic events following transient global ischemia.
Brain research 1998;790(1-2):1-13.
1998: T James; Deborah Denise Matzelle; raymond bartus; Edward Leo Hogan; Narendra L. Banik
New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro.
Journal of neuroscience research 1998;51(2):218-22.
1998: Ann-Charlotte E. Granholm-Bentley; David S Albeck; Cristina Bäckman; M Curtis; Ted Ebendal; Phillip Friden; Michael Henry; Barry Hoffer; Jeffrey Kordower; Gregory M Rose; Stine Söderström; raymond bartus
A non-invasive system for delivering neural growth factors across the blood-brain barrier: a review.
Reviews in the neurosciences 1998;9(1):31-55.
1998: M G Riley; N N Kim; V E Watson; Yves Gobin; C P LeBel; K L Black; raymond bartus
Intra-arterial administration of carboplatin and the blood brain barrier permeabilizing agent, RMP-7: a toxicologic evaluation in swine.
Journal of neuro-oncology 1998;36(2):167-78.
1997: Cristina Bäckman; Gregory M Rose; raymond bartus; Barry Hoffer; Elliott J Mufson; Ann-Charlotte E. Granholm-Bentley
Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors.
The Journal of comparative neurology 1997;387(1):1-11.
1997: K Matsukado; S Nakano; raymond bartus; KL Black
Steroids decrease uptake of carboplatin in rat gliomas--uptake improved by intracarotid infusion of bradykinin analog, RMP-7.
Journal of neuro-oncology 1997;34(2):131-8.
1997: K Matsukado; S Nakano; raymond bartus; KL Black
Steroids decrease uptake of carboplatin in rat gliomas--uptake improved by intracarotid infusion of bradykinin analog, RMP-7.
Acta neurochirurgica. Supplement 1997;70():159-61.
1997: BR Perri; Douglas H Smith; H Murai; Grant P Sinson; Kathryn E Saatman; Ramesh Raghupathi; raymond bartus; Tracy K McIntosh
Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat.
Journal of neurotrauma 1997;14(1):15-22.
1997: P J Elliot; raymond bartus; Jasmina B Mackic; Berislav V Zlokovic
Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir.
Pharmaceutical research 1997;14(1):80-5.
1996: raymond bartus; P J Elliott; R L Dean; N J Hayward; T L Nagle; M R Huff; Pamela Snodgrass; D G Blunt
Controlled modulation of BBB permeability using the bradykinin agonist, RMP-7.
Experimental neurology 1996;142(1):14-28.
1996: P J Elliott; N J Hayward; M R Huff; T L Nagle; K L Black; raymond bartus
Unlocking the blood-brain barrier: a role for RMP-7 in brain tumor therapy.
Experimental neurology 1996;141(2):214-24.
1996: Cristina Bäckman; Gregory M Rose; Barry Hoffer; Michael Henry; raymond bartus; Phillip Friden; Ann-Charlotte E. Granholm-Bentley
Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(17):5437-42.
1996: P J Elliott; N J Hayward; R L Dean; D G Blunt; raymond bartus
Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors.
Cancer research 1996;56(17):3998-4005.
1996: V Charles; Elliott J Mufson; Phillip Friden; raymond bartus; Jeffrey Kordower
Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate.
Brain research 1996;728(2):193-203.
1996: Koichiro Matsukado; Takanori Inamura; S Nakano; Masashi Fukui; raymond bartus; K L Black
Enhanced tumor uptake of carboplatin and survival in glioma-bearing rats by intracarotid infusion of bradykinin analog, RMP-7.
Neurosurgery 1996;39(1):125-33; discussion 133-4.
1996: raymond bartus; P Elliott; N Hayward; R Dean; E L McEwen; Stephen K Fisher
Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: evidence for a sensitive, auto-regulated, receptor-mediated system.
Immunopharmacology 1996;33(1-3):270-8.
1996: P J Elliott; N J Hayward; R L Dean; raymond bartus
Dissociation of blood-brain barrier permeability and the hypotensive effects of the bradykinin B2 agonist, RMP-7.
Immunopharmacology 1996;33(1-3):205-8.
1996: N J Hayward; P J Elliott; S D Sawyer; R T Bronson; raymond bartus
Lack of evidence for neutrophil participation during infarct formation following focal cerebral ischemia in the rat.
Experimental neurology 1996;139(2):188-202.
1996: Kathryn E Saatman; H Murai; raymond bartus; Douglas H Smith; N J Hayward; B R Perri; Tracy K McIntosh
Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3428-33.
1995: E Sanovich; raymond bartus; Phillip Friden; R L Dean; H Q Le; M W Brightman
Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7.
Brain research 1995;705(1-2):125-35.
1995: raymond bartus; R L Dean; K Cavanaugh; D Eveleth; D L Carriero; G Lynch
Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(6):969-79.
1995: P J Elliott; Jasmina B Mackic; W F Graney; raymond bartus; Berislav V Zlokovic
RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig.
Investigative ophthalmology & visual science 1995;36(12):2542-7.
1995: raymond bartus; P J Elliott; N J Hayward; R L Dean; S Harbeson; J A Straub; Z Li; James C Powers
Calpain as a novel target for treating acute neurodegenerative disorders.
Neurological research 1995;17(4):249-58.
1994: M Morehead; raymond bartus; R L Dean; J A Miotke; S Murphy; J Sall; H Goldman
Histopathologic consequences of moderate concussion in an animal model: correlations with duration of unconsciousness.
Journal of neurotrauma 1994;11(6):657-67.
1994: raymond bartus; N J Hayward; P J Elliott; S D Sawyer; K L Baker; R L Dean; A Akiyama; J A Straub; S L Harbeson; Z Li
Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.
Stroke; a journal of cerebral circulation 1994;25(11):2265-70.
1994: T Inamura; T Nomura; raymond bartus; K L Black
Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors.
Journal of neurosurgery 1994;81(5):752-8.
1994: Jeffrey Kordower; V Charles; R Bayer; raymond bartus; S Putney; L R Walus; Phillip Friden
Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):9077-80.
1994: raymond bartus; K L Baker; A D Heiser; S D Sawyer; R L Dean; P J Elliott; J A Straub
Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(4):537-44.
1994: M C Maillard; O Nikodijević; Kathryn F Lanoue; Deborah A Berkich; Xiao-Duo Ji; raymond bartus; Kenneth Alan Jacobson
Adenosine receptor prodrugs: synthesis and biological activity of derivatives of potent, A1-selective agonists.
Journal of pharmaceutical sciences 1994;83(1):46-53.
1993: DK von Lubitz; I A Paul; raymond bartus; Kenneth Alan Jacobson
Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory.
European journal of pharmacology 1993;249(3):271-80.
1993: raymond bartus
General overview: past contributions and future opportunities using aged nonhuman primates.
Neurobiology of aging 1993;14(6):711-4.
1993: S L Wagner; William E Van Nostrand; A L Lau; J S Farrow; M Suzuki; raymond bartus; R Schuppek; A Nguyen; Carl W Cotman; Dennis D Cunningham
Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates.
Brain research 1993;626(1-2):90-8.
1993: Z Li; G S Patil; Z E Golubski; H Hori; K Tehrani; J E Foreman; D D Eveleth; raymond bartus; James C Powers
Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases.
Journal of medicinal chemistry 1993;36(22):3472-80.
1991: Paulin Moszczynski; P Moszczynski; S Słowinski; S Bem; raymond bartus
Parameters of immunity acute phase reaction in men in relation to exposure duration to mercury vapours.
Journal of hygiene, epidemiology, microbiology, and immunology 1991;35(4):351-60.
1990: raymond bartus
Drugs to treat age-related neurodegenerative problems. The final frontier of medical science?
Journal of the American Geriatrics Society 1990;38(6):680-95.
1990: C Flicker; Steven H Ferris; T Crook; raymond bartus
Impaired facial recognition memory in aging and dementia.
Alzheimer disease and associated disorders 1990;4(1):43-54.
1990: L F Jarvik; L Berg; raymond bartus; L Heston; N Leith; C Phelps; R Shader; Peter J Whitehouse
Clinical drug trials in Alzheimer disease. What are some of the issues?
Alzheimer disease and associated disorders 1990;4(4):193-202.
1989: raymond bartus
The ultimate Shakespearean tragedy: are selective areas of the brain committing suicide?
Neurobiology of aging 1989;10(5):591.
1989: raymond bartus
Neurotrophic factors: the good, the bad or the ugly?
Neurobiology of aging 1989;10(5):555.
1989: raymond bartus
Neurotrophic factors: can the degenerating brain be induced to heal itself?
Neurobiology of aging 1989;10(5):513.
1989: raymond bartus
Alzheimer's amyloid: is it possible it's not rotten to the core.
Neurobiology of aging 1989;10(5):479.
1989: raymond bartus
A new orientation to an old problem: it's simply a matter of time.
Neurobiology of aging 1989;10(5):449.
1989: raymond bartus
The study of Alzheimer's pathology: the long and winding road.
Neurobiology of aging 1989;10(5):385-6.
1989: raymond bartus
The impending Alzheimer's crisis: can we be saved by the revolution?
Neurobiology of aging 1989;10(5):383-4.
1989: raymond bartus
Designer genes: current fad or lasting fashion?
Neurobiology of aging 1989;10(5):415.