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Deborah Card

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Lin Yan; Pei Huo; Jeffrey J Hale; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Suzanne Mandala
SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.
Lin Yan; Pei Huo; George Doherty; Leslie Toth; Jeffrey J Hale; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Elizabeth J Quackenbush; Alexandra Wickham; Suzanne Mandala
Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.
Lin Yan; Richard J Budhu; Pei Huo; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Suzanne Mandala
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.

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All Publications

2007: Lin Yan; Pei Huo; Jeffrey J Hale; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Suzanne Mandala
SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 2007;17(3):828-31.
2006: Lin Yan; Pei Huo; George Doherty; Leslie Toth; Jeffrey J Hale; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Elizabeth J Quackenbush; Alexandra Wickham; Suzanne Mandala
Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.
Bioorganic & medicinal chemistry letters 2006;16(14):3679-83.
2006: Lin Yan; Richard J Budhu; Pei Huo; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Suzanne Mandala
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorganic & medicinal chemistry letters 2006;16(13):3564-8.
2006: Vincent J Colandrea; Irene E Legiec; Pei Huo; Lin Yan; Jeffrey J Hale; Sander G Mills; James Bergstrom; Deborah Card; Gary Chebret; Richard Hajdu; Carol Ann Keohane; James A Milligan; Mark J Rosenbach; Gan-Ju Shei; Suzanne Mandala
2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.
Bioorganic & medicinal chemistry letters 2006;16(11):2905-8.
2005: Zhen Li; Weirong Chen; Jeffrey J Hale; Christopher L Lynch; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; Stephen A Parent; James Bergstrom; Deborah Card; Michael J Forrest; Elizabeth J Quackenbush; L Alexandra Wickham; Hugo Vargas; Rose M Evans; Hugh Rosen; Suzanne Mandala
Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
Journal of medicinal chemistry 2005;48(20):6169-73.
2004: Jeffrey J Hale; Christopher L Lynch; William Neway; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Stephen A Parent; Gary Chrebet; James Bergstrom; Deborah Card; Marc Ferrer; Peter Hodder; Berta Strulovici; Hugh Rosen; Suzanne Mandala
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
Journal of medicinal chemistry 2004;47(27):6662-5.
2004: Lin Yan; Jeffrey J Hale; Christopher L Lynch; Richard J Budhu; Amy L Gentry; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Hugh Rosen; Suzanne Mandala
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorganic & medicinal chemistry letters 2004;14(19):4861-6.
2004: Jeffrey J Hale; Lin Yan; William Neway; Richard Hajdu; James Bergstrom; James A Milligan; Gan-Ju Shei; Gary Chrebet; Rosemary Thornton; Deborah Card; Mark J Rosenbach; Suzanne Mandala
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.
Bioorganic & medicinal chemistry 2004;12(18):4803-7.
2004: Jeffrey J Hale; George Doherty; Leslie Toth; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Michael J Forrest; Shu-Yu Sun; Sarah West; Huijuan Xie; Naomi Nomura; Hugh Rosen; Suzanne Mandala
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.
Bioorganic & medicinal chemistry letters 2004;14(13):3501-5.
2004: Jeffrey J Hale; George Doherty; Leslie Toth; Zhen Li; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Hugh Rosen; Suzanne Mandala
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Bioorganic & medicinal chemistry letters 2004;14(13):3495-9.
2004: Jeffrey J Hale; William Neway; Sander G Mills; Richard Hajdu; Carol Ann Keohane; Mark J Rosenbach; James A Milligan; Gan-Ju Shei; Gary Chrebet; James Bergstrom; Deborah Card; Gloria C Koo; Sam L Koprak; Jesse J Jackson; Hugh Rosen; Suzanne Mandala
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Bioorganic & medicinal chemistry letters 2004;14(12):3351-5.
2004: Michael J Forrest; S-Y Sun; Richard Hajdu; James Bergstrom; Deborah Card; George Doherty; Jeffrey Hale; Carol Ann Keohane; CAREN MEYERS; James A Milligan; S Mills; N Nomura; Hugh Rosen; Mark J Rosenbach; Gan-Ju Shei; Irwin I Singer; M Tian; S West; V White; J Xie; Richard L Proia; Suzanne Mandala
Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
The Journal of pharmacology and experimental therapeutics 2004;309(2):758-68.
2002: Suzanne Mandala; Richard Hajdu; James Bergstrom; Elizabeth J Quackenbush; Jenny Xie; James A Milligan; Rosemary Thornton; Gan-Ju Shei; Deborah Card; Carol Ann Keohane; Mark J Rosenbach; Jeffrey Hale; Christopher L Lynch; Kathleen M Rupprecht; William H Parsons; Hugh Rosen
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Science (New York, N.Y.) 2002;296(5566):346-9.
2000: Patricia A Detmers; Melba Hernandez; John S Mudgett; Heide Hassing; Charlotte Burton; Steven S Mundt; S Chun; D Fletcher; Deborah Card; JeanMarie Lisnock; R Weikel; James Bergstrom; D E Shevell; Anne Hermanowski-Vosatka; Carl P Sparrow; Yu-Sheng Chao; D J Rader; Samuel D Wright; Ellen Puré
Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3430-5.
2000: Samuel D Wright; C Burton; Melba Hernandez; Heide Hassing; J Montenegro; Steven S Mundt; S Patel; Deborah Card; Anne Hermanowski-Vosatka; James Bergstrom; Carl P Sparrow; Patricia A Detmers; Yu-Sheng Chao
Infectious agents are not necessary for murine atherogenesis.
The Journal of experimental medicine 2000;191(8):1437-42.