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Stephen Polyak

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Stephen Polyak; Peter Ferenci; Jean-Michel Pawlotsky
Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection.
Janela McClure; John E Mittler; Leonidas Stamatatos; Jessica Wagoner; Robert W Coombs; Stephen C De Rosa; Joan Dragavon; Shokrollah Elahi; Helen Horton; Zane Kraft; Erica S Lovelace; Nicholas J Maurice; Stephen Polyak
Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation.
Jessica Wagoner; Chihiro Morishima; Tyler N Graf; Nicholas H Oberlies; Elodie Teissier; Eve-Isabelle Pécheur; John E Tavis; Stephen Polyak
Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.

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All Publications

2013: Stephen Polyak; Peter Ferenci; Jean-Michel Pawlotsky
Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2013;57(3):1262-71.
2012: Janela McClure; John E Mittler; Leonidas Stamatatos; Jessica Wagoner; Robert W Coombs; Stephen C De Rosa; Joan Dragavon; Shokrollah Elahi; Helen Horton; Zane Kraft; Erica S Lovelace; Nicholas J Maurice; Stephen Polyak
Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation.
PloS one 2012;7(7):e41832.
2011: Jessica Wagoner; Chihiro Morishima; Tyler N Graf; Nicholas H Oberlies; Elodie Teissier; Eve-Isabelle Pécheur; John E Tavis; Stephen Polyak
Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.
PloS one 2011;6(1):e16464.
2010: Jessica Wagoner; Amina Negash; Olivia J Kane; Laura E Martinez; Yaakov Nahmias; Nigel Bourne; David M Owen; Joe Grove; Claire Brimacombe; Jane A McKeating; Eve-Isabelle Pécheur; Tyler N Graf; Nicholas H Oberlies; Volker Lohmann; Feng Cao; John E Tavis; Stephen Polyak
Multiple effects of silymarin on the hepatitis C virus lifecycle.
Hepatology (Baltimore, Md.) 2010;51(6):1912-21.
2008: Stephen Polyak; Chihiro Morishima; Roy L Hawke
Antiviral effects of silymarin against hepatitis C: the jury is still out.
Hepatology (Baltimore, Md.) 2008;48(1):345-6.
2008: Y S Boriskin; I A Leneva; E-I Pécheur; Stephen Polyak
Arbidol: a broad-spectrum antiviral compound that blocks viral fusion.
Current medicinal chemistry 2008;15(10):997-1005.
2008: Raymond T Chung; Michael Gale; Stephen Polyak; Stanley M Lemon; TSANYANG LIANG; Jay H Hoofnagle
Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop.
Hepatology (Baltimore, Md.) 2008;47(1):306-20.
2007: Anne M Wertheimer; Stephen Polyak; Rachel L Leistikow; Hugo Rosen
Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells.
Hepatology (Baltimore, Md.) 2007;45(6):1422-32.
2007: Eve-Isabelle Pécheur; Dimitri Lavillette; Fanny Alcaras; Jennifer Molle; Yury S Boriskin; Michael Roberts; François-Loïc Cosset; Stephen Polyak
Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol.
Biochemistry 2007;46(20):6050-9.
2007: Stephen Polyak; Chihiro Morishima; Margaret C Shuhart; Chia C Wang; Yanze Liu; David Y W Lee
Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin.
Gastroenterology 2007;132(5):1925-36.
2007: Jessica Wagoner; Michael Austin; Jamison Green; Tadaatsu Imaizumi; Antonella Casola; allan brasier; Khalid S A Khabar; Takaji Wakita; Michael Gale; Stephen Polyak
Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection.
Journal of virology 2007;81(1):309-18.
2006: Bon Chang A Koo; Paula McPoland; Jessica P Wagoner; Olivia J Kane; Volker Lohmann; Stephen Polyak
Relationships between hepatitis C virus replication and CXCL-8 production in vitro.
Journal of virology 2006;80(16):7885-93.
2006: Gyongyi Szabo; Costica Aloman; Stephen Polyak; Steven Weinman; Jack R Wands; Samir Zakhari
Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity.
Alcoholism, clinical and experimental research 2006;30(4):709-19.
2006: Chihiro Morishima; Stephen Polyak; Ranjit Ray; Michael C Doherty; Adrian M Di Bisceglie; Peter F Malet; Herbert L Bonkovsky; Daniel G Sullivan; David R Gretch; Alan L Rothman; Margaret James Koziel; Karen L Lindsay
Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C.
The Journal of infectious diseases 2006;193(7):931-40.
2006: Jamison Green; Khalid S A Khabar; Bon Chang A Koo; Bryan R G Williams; Stephen Polyak
Stability of CXCL-8 and related AU-rich mRNAs in the context of hepatitis C virus replication in vitro.
The Journal of infectious diseases 2006;193(6):802-11.
2006: Yury S Boriskin; Eve-Isabelle Pécheur; Stephen Polyak
Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection.
Virology journal 2006;3():56.
2005: Gyongyi Szabo; Steven Weinman; Bin Gao; Stephen Polyak; Pranoti Mandrekar; Geoffrey M Thiele
RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease.
Alcoholism, clinical and experimental research 2005;29(9):1753-7.
2005: Alan Lee Rothman; Chihiro Morishima; Herbert L Bonkovsky; Stephen Polyak; Ranjit Ray; Adrian M Di Bisceglie; Karen L Lindsay; Peter F Malet; Ming Chang; David R Gretch; Daniel G Sullivan; Atul K Bhan; Elizabeth C Wright; Margaret James Koziel
Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C.
Hepatology (Baltimore, Md.) 2005;41(3):617-25.
2005: Courtney R Plumlee; Catherine Lazaro; Nelson Fausto; Stephen Polyak
Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells.
Virology journal 2005;2():89.
2005: Stephen Polyak; Daniel G Sullivan; Michael A Austin; James Y Dai; Margaret C Shuhart; Karen L Lindsay; Herbert L Bonkovsky; Adrian M Di Bisceglie; William M Lee; Chihiro Morishima; David R Gretch
Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis.
Virology journal 2005;2():41.
2004: Khalid S A Khabar; Latifa al-Haj; Fahad Al-Zoghaibi; Mohammad Marie; Mohammed Dhalla; Stephen Polyak; Bryan R G Williams
Expressed gene clusters associated with cellular sensitivity and resistance towards anti-viral and anti-proliferative actions of interferon.
Journal of molecular biology 2004;342(3):833-46.
2004: Kevin C Klein; Stephen Polyak; Jaisri R Lingappa
Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly.
Journal of virology 2004;78(17):9257-69.
2004: Kristen Miller; Susan McArdle; Michael J Gale; David A Geller; Benjamin R Tenoever; John Hiscott; David R Gretch; Stephen Polyak
Effects of the hepatitis C virus core protein on innate cellular defense pathways.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004;24(7):391-402.
2003: Chia Wang; Stephen Polyak; Lawrence Corey
Detection of hepatitis C virus RNA in normal cervical smears.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003;37(2):314; author reply 314-5.
2003: Stephen Polyak
Hepatitis C virus--cell interactions and their role in pathogenesis.
Clinics in liver disease 2003;7(1):67-88.
2002: Khalid S A Khabar; Stephen Polyak
Hepatitis C virus-host interactions: the NS5A protein and the interferon/chemokine systems.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(10):1005-12.
2002: Yupeng He; Haruhisa Nakao; Seng-Lai Tan; Stephen Polyak; Petra Neddermann; Sangeetha Vijaysri; Bertram L Jacobs; Michael G Katze
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.
Journal of virology 2002;76(18):9207-17.
2002: Stephanie T Shi; Stephen Polyak; Hong Tu; Deborah R Taylor; David R Gretch; Michael M C Lai
Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins.
Virology 2002;292(2):198-210.
2001: Frederick S. Nolte; Michael W Fried; Mitchell L Shiffman; Andrea Ferreira-Gonzalez; Carleton T Garrett; Eugene R Schiff; Stephen Polyak; D R Gretch
Prospective multicenter clinical evaluation of AMPLICOR and COBAS AMPLICOR hepatitis C virus tests.
Journal of clinical microbiology 2001;39(11):4005-12.
2001: Stephen Polyak; Khalid S A Khabar; M Rezeiq; David R Gretch
Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy.
Journal of virology 2001;75(13):6209-11.
2001: Stephen Polyak; Khalid S A Khabar; Denise M Paschal; Heather Ezelle; G Duverlie; Glen N Barber; D E Levy; N Mukaida; David R Gretch
Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.
Journal of virology 2001;75(13):6095-106.
2001: Heather Ezelle; Siddharth Balachandran; F Sicheri; Stephen Polyak; Glen N Barber
Analyzing the mechanisms of interferon-induced apoptosis using CrmA and hepatitis C virus NS5A.
Virology 2001;281(1):124-37.
2000: J Nousbaum; Stephen Polyak; Stuart C Ray; Daniel G Sullivan; Anne M Larson; Robert L Carithers; David R Gretch
Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy.
Journal of virology 2000;74(19):9028-38.
2000: Stephen Polyak; J B Nousbaum; Anne M Larson; Scott J Cotler; Robert L Carithers; David R Gretch
The protein kinase-interacting domain in the hepatitis C virus envelope glycoprotein-2 gene is highly conserved in genotype 1-infected patients treated with interferon.
The Journal of infectious diseases 2000;182(2):397-404.
2000: Stephen Polyak; Martina Gerotto
The molecular basis for responsiveness to anti-viral therapy in hepatitis C.
Forum (Genoa, Italy) 2000;10(1):46-58.
1999: Martina Gerotto; Francesca Dal Pero; Daniel G Sullivan; Liliana Chemello; Luisa Cavalletto; Stephen Polyak; Patrizia Pontisso; David R Gretch; Alfredo Alberti
Evidence for sequence selection within the non-structural 5A gene of hepatitis C virus type 1b during unsuccessful treatment with interferon-alpha.
Journal of viral hepatitis 1999;6(5):367-72.
1999: Martina Gerotto; Daniel G Sullivan; Stephen Polyak; Liliana Chemello; Luisa Cavalletto; Patrizia Pontisso; Alfredo Alberti; David R Gretch
Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C.
Journal of virology 1999;73(9):7241-7.
1999: Stephen Polyak; Denise M Paschal; Susan McArdle; Michael J Gale; D Moradpour; David R Gretch
Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication.
Hepatology (Baltimore, Md.) 1999;29(4):1262-71.
1998: Michael Gale; Collin M Blakely; Bartlomiej K Kwieciszewski; Seng-Lai Tan; M Dossett; NM Tang; Marcus J Korth; Stephen Polyak; David R Gretch; Michael G Katze
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.
Molecular and cellular biology 1998;18(9):5208-18.
1998: Stephen Polyak; Susan McArdle; Shan-Lu Liu; Daniel G Sullivan; Minjun Chung; WT Hofgärtner; Robert L Carithers; Brian J McMahon; James I Mullins; Lawrence Corey; David R Gretch
Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.
Journal of virology 1998;72(5):4288-96.
1997: WT Hofgärtner; Stephen Polyak; Daniel G Sullivan; Robert L Carithers; David R Gretch
Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b.
Journal of medical virology 1997;53(2):118-26.
1997: Stephen Polyak; G Faulkner; Robert L Carithers; Lawrence Corey; David R Gretch
Assessment of hepatitis C virus quasispecies heterogeneity by gel shift analysis: correlation with response to interferon therapy.
The Journal of infectious diseases 1997;175(5):1101-7.
1997: Michael J Gale; Marcus J Korth; NM Tang; Seng-Lai Tan; D A Hopkins; T E Dever; Stephen Polyak; David R Gretch; Michael G Katze
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein.
Virology 1997;230(2):217-27.
1996: André Lieber; Cheng-Yi He; Stephen Polyak; David R Gretch; Dana Barr; Mark A Kay
Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes.
Journal of virology 1996;70(12):8782-91.
1996: David R Gretch; Stephen Polyak; J J Wilson; Robert L Carithers; James D Perkins; Lawrence Corey
Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients.
Journal of virology 1996;70(11):7622-31.
1996: Stephen Polyak; N Tang; M Wambach; Glen N Barber; Michael G Katze
The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.
The Journal of biological chemistry 1996;271(3):1702-7.
1996: David R Gretch; Stephen Polyak; Richard A Willson; Robert L Carithers
Treatment of chronic hepatitis C virus infection: a clinical and virological perspective.
Advances in experimental medicine and biology 1996;394():207-24.
1995: J J Wilson; Stephen Polyak; T D Day; David R Gretch
Characterization of simple and complex hepatitis C virus quasispecies by heteroduplex gel shift analysis: correlation with nucleotide sequencing.
The Journal of general virology 1995;76 ( Pt 7)():1763-71.
1995: Stephen Polyak; S Zheng; D G Harnish
5' termini of Pichinde arenavirus S RNAs and mRNAs contain nontemplated nucleotides.
Journal of virology 1995;69(5):3211-5.
1995: Stephen Polyak; S Zheng; D G Harnish
Analysis of Pichinde arenavirus transcription and replication in human THP-1 monocytic cells.
Virus research 1995;36(1):37-48.
1991: Stephen Polyak; W E Rawls; D G Harnish
Characterization of Pichinde virus infection of cells of the monocytic lineage.
Journal of virology 1991;65(7):3575-82.