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william boyle

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Gadi Gazit Bornstein; Scott L Klakamp; Laura Andrews; william boyle; Mohammad A Tabrizi
Surrogate approaches in development of monoclonal antibodies.
Paul J Kostenuik; Hung Q Nguyen; James McCabe; Kelly Warmington; Carol Kurahara; Ning Sun; Ching Chen; Luke Li; Russell C Cattley; Gwyneth Van; Sheila Scully; Robin Elliott; Mario Grisanti; Sean Morony; Hong Lin Tan; Frank Asuncion; Xiaodong Li; Michael Ominsky; Marina Stolina; Denise Dwyer; William C Dougall; N Hawkins; william boyle; William S Simonet; John K Sullivan
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.
Keith S Kwak; Xiaolan Zhou; Vered Solomon; Vickie E Baracos; James Davis; Anthony W Bannon; william boyle; David L Lacey; H Q Han
Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.

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2009: Gadi Gazit Bornstein; Scott L Klakamp; Laura Andrews; william boyle; Mohammad A Tabrizi
Surrogate approaches in development of monoclonal antibodies.
Drug discovery today 2009;14(23-24):1159-65.
2009: Paul J Kostenuik; Hung Q Nguyen; James McCabe; Kelly Warmington; Carol Kurahara; Ning Sun; Ching Chen; Luke Li; Russell C Cattley; Gwyneth Van; Sheila Scully; Robin Elliott; Mario Grisanti; Sean Morony; Hong Lin Tan; Frank Asuncion; Xiaodong Li; Michael Ominsky; Marina Stolina; Denise Dwyer; William C Dougall; N Hawkins; william boyle; William S Simonet; John K Sullivan
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(2):182-95.
2004: Keith S Kwak; Xiaolan Zhou; Vered Solomon; Vickie E Baracos; James Davis; Anthony W Bannon; william boyle; David L Lacey; H Q Han
Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.
Cancer research 2004;64(22):8193-8.
2003: william boyle; W Scott Simonet; David L Lacey
Osteoclast differentiation and activation.
Nature 2003;423(6937):337-42.
2003: Guiti Z Eghbali-Fatourechi; Sundeep Khosla; Arunik Sanyal; william boyle; David L Lacey; Lawrence B. Riggs
Role of RANK ligand in mediating increased bone resorption in early postmenopausal women.
The Journal of clinical investigation 2003;111(8):1221-30.
2002: Brad Bolon; Victoria Shalhoub; Paul J Kostenuik; Giuseppe Campagnuolo; Sean Morony; william boyle; Debra Zack; Ulrich Feige
Osteoprotegerin, an endogenous antiosteoclast factor for protecting bone in rheumatoid arthritis.
Arthritis and rheumatism 2002;46(12):3121-35.
2002: Lars E Theill; william boyle; Josef M Penninger
RANK-L and RANK: T cells, bone loss, and mammalian evolution.
Annual review of immunology 2002;20():795-823.
2001: Jason J Rosenberg; S W Martin; J E Seely; Olaf Kinstler; Gregory C Gaines; K Fukuzuka; J Rose; T Kohno; william boyle; A Nelson; GL Kieft; W S Marshall; Ulrich Feige; J Gasser; J St Clair; J Frazier; Amer Abouhamze; Lyle L Moldawer; Carl K Edwards
Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(5):2213-23.
2001: T Yan; Lawrence B. Riggs; william boyle; Sundeep Khosla
Regulation of osteoclastogenesis and RANK expression by TGF-beta1.
Journal of cellular biochemistry 2001;83(2):320-5.
2000: Victoria Shalhoub; Gary Elliott; L Chiu; Raffi Manoukian; M Kelley; N Hawkins; E Davy; Grant Shimamoto; J Beck; Stephen A Kaufman; Gwyneth Van; Sheila Scully; M Qi; Mario Grisanti; Colin R Dunstan; william boyle; David L Lacey
Characterization of osteoclast precursors in human blood.
British journal of haematology 2000;111(2):501-12.
2000: Young-Yun Kong; william boyle; Josef M Penninger
Osteoprotegerin ligand: a regulator of immune responses and bone physiology.
Immunology today 2000;21(10):495-502.
2000: Jimmie E Fata; Young-Yun Kong; Joyce Li; Takehiko Sasaki; Junko Irie-Sasaki; Roger A Moorehead; R Elliott; Sheila Scully; EB Voura; David L Lacey; william boyle; Rama Khokha; Josef M Penninger
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
Cell 2000;103(1):41-50.
2000: G Yu; Tom Boone; J Delaney; N Hawkins; M Kelley; M Ramakrishnan; Susan McCabe; W R Qiu; M Kornuc; XZ Xia; Jane Guo; Marina Stolina; william boyle; Ildiko Sarosi; H Hsu; Giorgio Senaldi; Lars E Theill
APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.
Nature immunology 2000;1(3):252-6.
2000: Hosung Min; Sean Morony; Ildiko Sarosi; Colin R Dunstan; Charles Capparelli; Sheila Scully; Gwyneth Van; Stephen Kaufman; Paul J Kostenuik; David L Lacey; william boyle; W Scott Simonet
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis.
The Journal of experimental medicine 2000;192(4):463-74.
2000: David L Lacey; Hong Lin Tan; J Lu; Stephen Kaufman; Gwyneth Van; W Qiu; Alana Rattan; Sheila Scully; Frederick A Fletcher; Todd Juan; M Kelley; Teresa L Burgess; william boyle; A J Polverino
Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo.
The American journal of pathology 2000;157(2):435-48.
2000: XZ Xia; J Treanor; Giorgio Senaldi; SD Khare; Tom Boone; M Kelley; Lars E Theill; A Colombero; I Solovyev; F Lee; Susan McCabe; R Elliott; K Miner; N Hawkins; Jane Guo; Marina Stolina; G Yu; J Wang; J Delaney; S Y Meng; william boyle; H Hsu
TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.
The Journal of experimental medicine 2000;192(1):137-43.
2000: SD Khare; Ildiko Sarosi; XZ Xia; Susan McCabe; K Miner; I Solovyev; N Hawkins; M Kelley; D Chang; Gwyneth Van; L Ross; J Delaney; L Wang; David L Lacey; william boyle; H Hsu
Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3370-5.
2000: J Li; Ildiko Sarosi; xiao yan; Sean Morony; Charles Capparelli; Hong Lin Tan; Susan McCabe; R Elliott; Sheila Scully; Gwyneth Van; Stephen Kaufman; S C Juan; Y Sun; John L Tarpley; L Martin; K Christensen; James McCabe; Paul J Kostenuik; H Hsu; Frederick A Fletcher; Colin R Dunstan; David L Lacey; william boyle
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1566-71.
2000: Lorenz C Hofbauer; Sundeep Khosla; Colin R Dunstan; David L Lacey; william boyle; Lawrence B. Riggs
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(1):2-12.
1999: Young-Yun Kong; Ulrich Feige; Ildiko Sarosi; Brad Bolon; A Tafuri; Sean Morony; Charles Capparelli; J Li; R Elliott; Susan McCabe; T Wong; Giuseppe Campagnuolo; E Moran; Earl R Bogoch; Gwyneth Van; L T Nguyen; Pamela S Ohashi; David L Lacey; E Fish; william boyle; Josef M Penninger
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
Nature 1999;402(6759):304-9.
1999: Teresa L Burgess; Y Qian; Stephen Kaufman; B D Ring; Gwyneth Van; Charles Capparelli; M Kelley; H Hsu; william boyle; Colin R Dunstan; S Hu; David L Lacey
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.
The Journal of cell biology 1999;145(3):527-38.
1999: Mark A Lomaga; Wen-Chen Yeh; Ildiko Sarosi; Gordon S Duncan; Caren Furlonger; Alexandra Ho; Sean Morony; Charles Capparelli; Gwyneth Van; Stephen Kaufman; A van der Heiden; Annick Itie; Andrew Wakeham; W Khoo; Takehiko Sasaki; Z Cao; Josef M Penninger; Christopher J Paige; David L Lacey; Colin R Dunstan; william boyle; David V Goeddel; Tak W Mak
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Genes & development 1999;13(8):1015-24.
1999: Young-Yun Kong; william boyle; J M Penninger
Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development.
Immunology and cell biology 1999;77(2):188-93.
1999: H Hsu; David L Lacey; Colin R Dunstan; I Solovyev; A Colombero; E Timms; Hong Lin Tan; Gary Elliott; M J Kelley; Ildiko Sarosi; L Wang; XZ Xia; R Elliott; L Chiu; T Black; Sheila Scully; Charles Capparelli; Sean Morony; Grant Shimamoto; M B Bass; william boyle
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3540-5.
1999: Victoria Shalhoub; J Faust; william boyle; Colin R Dunstan; M Kelley; Stephen Kaufman; Sheila Scully; Gwyneth Van; David L Lacey
Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors.
Journal of cellular biochemistry 1999;72(2):251-61.
1999: Young-Yun Kong; H Yoshida; Ildiko Sarosi; Hong Lin Tan; E Timms; Charles Capparelli; Sean Morony; Antonio J Oliveira-dos-Santos; Gwyneth Van; Annick Itie; W Khoo; Andrew Wakeham; Colin R Dunstan; David L Lacey; Tak W Mak; william boyle; Josef M Penninger
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Nature 1999;397(6717):315-23.
1998: N Bucay; Ildiko Sarosi; Colin R Dunstan; Sean Morony; John L Tarpley; Charles Capparelli; Sheila Scully; Hong Lin Tan; W Xu; David L Lacey; william boyle; W Scott Simonet
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Genes & development 1998;12(9):1260-8.
1998: David L Lacey; E Timms; Hong Lin Tan; M J Kelley; Colin R Dunstan; Teresa L Burgess; R Elliott; A Colombero; Gary Elliott; Sheila Scully; H Hsu; J Sullivan; N Hawkins; E Davy; Charles Capparelli; A Eli; Y X Qian; Stephen Kaufman; Ildiko Sarosi; Victoria Shalhoub; Giorgio Senaldi; Jane Guo; J Delaney; william boyle
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Cell 1998;93(2):165-76.
1997: H Hsu; I Solovyev; A Colombero; R Elliott; M Kelley; william boyle
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.
The Journal of biological chemistry 1997;272(21):13471-4.
1997: W Scott Simonet; David L Lacey; Colin R Dunstan; M Kelley; Ming-Shi Chang; R Lüthy; H Q Nguyen; S Wooden; L Bennett; Tom Boone; Grant Shimamoto; Margaret De Rose; R Elliott; A Colombero; Hong Lin Tan; G Trail; J Sullivan; E Davy; N Bucay; L Renshaw-Gegg; T M Hughes; Dave Hill; W Pattison; P Campbell; S Sander; Gwyneth Van; John L Tarpley; P Derby; R Lee; william boyle
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Cell 1997;89(2):309-19.
1994: R M Housley; C Fred Morris; william boyle; Brian Ring; R Biltz; J E Tarpley; SL Aukerman; P L Devine; R H Whitehead; Glenn F Pierce
Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.
The Journal of clinical investigation 1994;94(5):1764-77.
1994: T D Bartley; R W Hunt; Andrew A Welcher; william boyle; V P Parker; R A Lindberg; HS Lu; A Colombero; R L Elliott; B A Guthrie
B61 is a ligand for the ECK receptor protein-tyrosine kinase.
Nature 1994;368(6471):558-60.
1992: william boyle
Growth factors and tyrosine kinase receptors during development and cancer.
Current opinion in oncology 1992;4(1):156-62.
1991: william boyle; T Smeal; Bas Defize; Peter Angel; J R Woodgett; Michael Karin; Tony Hunter
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.
Cell 1991;64(3):573-84.
1991: william boyle; P van der Geer; Tony Hunter
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates.
Methods in enzymology 1991;201():110-49.
1988: R Chiu; william boyle; J Meek; T Smeal; Tony Hunter; Michael Karin
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes.
Cell 1988;54(4):541-52.
1988: Peter Angel; E A Allegretto; S T Okino; K Hattori; william boyle; Tony Hunter; Michael Karin
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.
Nature 1988;332(6160):166-71.
1988: Dennis J Slamon; william boyle; D E Keith; Michael F Press; David W Golde; L M Souza
Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I.
Journal of virology 1988;62(3):680-6.
1988: Tony Hunter; Peter Angel; william boyle; R Chiu; E Freed; K L Gould; C M Isacke; Michael Karin; R A Lindberg; P van der Geer
Targets for signal-transducing protein kinases.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():131-42.
1987: J L Evans; william boyle; Jenny P-Y Ting
Molecular basis of elevated c-myb expression in the abnormal L3T4-, Lyt-2- T lymphocytes of autoimmune mice.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3497-505.
1987: william boyle; Marcel A Baluda
Subnuclear associations of the v-myb oncogene product and actin are dependent on ionic strength during nuclear isolation.
Molecular and cellular biology 1987;7(9):3345-8.
1987: Joseph S Lipsick; william boyle
c-myb protein expression is a late event during T-lymphocyte activation.
Molecular and cellular biology 1987;7(9):3358-60.
1986: william boyle; Joseph S Lipsick; Marcel A Baluda
Antibodies to the evolutionarily conserved amino-terminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4685-9.
1985: william boyle; M A Lampert; A C Li; Marcel A Baluda
Nuclear compartmentalization of the v-myb oncogene product.
Molecular and cellular biology 1985;5(11):3017-23.
1984: william boyle; M A Lampert; Joseph S Lipsick; Marcel A Baluda
Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4265-9.
1983: K Bugra; R D Tanaka; william boyle; A J MacInnis
Isolation of poly A(+) RNA from Schistosoma mansoni and immunoprecipitation of its in vitro translation products.
The Journal of parasitology 1983;69(3):486-90.
1983: william boyle; Joseph S Lipsick; E P Reddy; Marcel A Baluda
Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(10):2834-8.