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Albert Jeltsch

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TOP 3
Albert Jeltsch
Oxygen, epigenetic signaling, and the evolution of early life.
Alexandre Ceccaldi; Hana Dali-Ali; Dominique Guianvarc'h; Albert Jeltsch; Christine Maulay-Bailly; Sergey Ragozin; Arumugam Rajavelu; Catherine Sénamaud-Beaufort; Noé Testa; Séverine Amand; Pavel Bashtrykov; Paola B Arimondo
Identification of novel inhibitors of DNA methylation by screening of a chemical library.
Abu Nasar Siddique; Yingying Zhang; Renata Z Jurkowska; Tomasz P Jurkowski; Suneetha Nunna; Sergey Ragozin; Arumugam Rajavelu; Richard Reinhardt; Marianne G Rots; Albert Jeltsch
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity.

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All Publications

2013: Albert Jeltsch
Oxygen, epigenetic signaling, and the evolution of early life.
Trends in biochemical sciences 2013;38(4):172-6.
2013: Alexandre Ceccaldi; Hana Dali-Ali; Dominique Guianvarc'h; Albert Jeltsch; Christine Maulay-Bailly; Sergey Ragozin; Arumugam Rajavelu; Catherine Sénamaud-Beaufort; Noé Testa; Séverine Amand; Pavel Bashtrykov; Paola B Arimondo
Identification of novel inhibitors of DNA methylation by screening of a chemical library.
ACS chemical biology 2013;8(3):543-8.
2013: Abu Nasar Siddique; Yingying Zhang; Renata Z Jurkowska; Tomasz P Jurkowski; Suneetha Nunna; Sergey Ragozin; Arumugam Rajavelu; Richard Reinhardt; Marianne G Rots; Albert Jeltsch
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity.
Journal of molecular biology 2013;425(3):479-91.
2013: Albert Jeltsch; Renata Z Jurkowska
Multimerization of the dnmt3a DNA methyltransferase and its functional implications.
Progress in molecular biology and translational science 2013;117():445-64.
2012: Maria Becker; Albert Jeltsch; Tomasz P Jurkowski; Sara Müller; Wolfgang Nellen; Ann E Ehrenhofer-Murray
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling.
Nucleic acids research 2012;40(22):11648-58.
2012: Srikanth Kudithipudi; Adam Fiseha Kebede; Arunkumar Dhayalan; Albert Jeltsch
The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues.
Biochimie 2012;94(11):2212-8.
2012: Pavel Bashtrykov; Sergey Ragozin; Albert Jeltsch
Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase.
FEBS letters 2012;586(13):1821-3.
2012: Razvan F Albu; Tomasz P Jurkowski; Martin Zacharias; Albert Jeltsch
DNA interaction of the CcrM DNA methyltransferase: a mutational and modeling study.
Chembiochem : a European journal of chemical biology 2012;13(9):1304-11.
2012: Tomasz P Jurkowski; Raghuvaran Shanmugam; Mark Helm; Albert Jeltsch
Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase.
Biochemistry 2012;51(22):4438-44.
2012: Pavel Bashtrykov; Gytis Jankevicius; Renata Z Jurkowska; Sergey Ragozin; Anita Smarandache; Albert Jeltsch
Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain.
Chemistry & biology 2012;19(5):572-8.
2012: Mara Florea; María José González-Álvarez; Albert Jeltsch; Srikanth Kudithipudi; Ana Rei; Werner M Nau
A fluorescence-based supramolecular tandem assay for monitoring lysine methyltransferase activity in homogeneous solution.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(12):3521-8.
2012: Razvan F Albu; Tomasz P Jurkowski; Albert Jeltsch
The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner.
Nucleic acids research 2012;40(4):1708-16.
2012: Arumugam Rajavelu; Renata Z Jurkowska; Jürgen Fritz; Albert Jeltsch
Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation.
Nucleic acids research 2012;40(2):569-80.
2011: Tomasz P Jurkowski; Albert Jeltsch
Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation.
Chembiochem : a European journal of chemical biology 2011;12(17):2543-5.
2011: Renata Z Jurkowska; Wolfgang Nellen; Sergey Ragozin; Arumugam Rajavelu; Claus Urbanke; Nils Anspach; Gytis Jankevicius; Albert Jeltsch
Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L.
The Journal of biological chemistry 2011;286(27):24200-7.
2011: Renata Z Jurkowska; Tomasz P Jurkowski; Abu Nasar Siddique; Albert Jeltsch
Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase.
Chembiochem : a European journal of chemical biology 2011;12(10):1589-94.
2011: Alexandre Ceccaldi; Christine Champion; Daniel Dauzonne; Nathalie Gagey; Dominique Guianvarc'h; Gytis Jankevicius; Albert Jeltsch; Renata Z Jurkowska; Loïc Ponger; Arumugam Rajavelu; Christine Rampon; Sindu Ros; Catherine Sénamaud-Beaufort; Jörg Tost; Sophie Vriz; Hana Dali Ali; Paola B Arimondo
C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.
Chembiochem : a European journal of chemical biology 2011;12(9):1337-45.
2011: Abu Nasar Siddique; Renata Z Jurkowska; Tomasz P Jurkowski; Albert Jeltsch
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.
The FEBS journal 2011;278(12):2055-63.
2011: Ina Bock; Arunkumar Dhayalan; Srikanth Kudithipudi; Ole Brandt; Philipp Rathert; Albert Jeltsch
Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays.
Epigenetics : official journal of the DNA Methylation Society 2011;6(2):256-63.
2011: Arunkumar Dhayalan; Srikanth Kudithipudi; Philipp Rathert; Albert Jeltsch
Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase.
Chemistry & biology 2011;18(1):111-20.
2011: Renata Z Jurkowska; Tomasz P Jurkowski; Albert Jeltsch
Structure and function of mammalian DNA methyltransferases.
Chembiochem : a European journal of chemical biology 2011;12(2):206-22.
2011: Tomasz P Jurkowski; Albert Jeltsch
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2.
PloS one 2011;6(11):e28104.
2011: Renata Z Jurkowska; Yingying Zhang; Paola B Arimondo; Alexandre Ceccaldi; Albert Jeltsch
DNA methyltransferase assays.
Methods in molecular biology (Clifton, N.J.) 2011;791():157-77.
2011: Ina Bock; Arunkumar Dhayalan; Srikanth Kudithipudi; Goran Kungulovski; Raluca Tamas; Albert Jeltsch
Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails.
BMC biochemistry 2011;12():48.
2011: Arumugam Rajavelu; Zumrad Tulyasheva; Rakesh Jaiswal; Albert Jeltsch; Nikolai Kuhnert
The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols.
BMC biochemistry 2011;12():16.
2010: Arunkumar Dhayalan; Arumugam Rajavelu; Philipp Rathert; Raluca Tamas; Renata Z Jurkowska; Sergey Ragozin; Albert Jeltsch
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.
The Journal of biological chemistry 2010;285(34):26114-20.
2010: Yingying Zhang; Renata Z Jurkowska; Szabolcs Soeroes; Arumugam Rajavelu; Arunkumar Dhayalan; Ina Bock; Philipp Rathert; Ole Brandt; Richard Reinhardt; Wolfgang Fischle; Albert Jeltsch
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail.
Nucleic acids research 2010;38(13):4246-53.
2010: Albert Jeltsch
Molecular biology. Phylogeny of methylomes.
Science (New York, N.Y.) 2010;328(5980):837-8.
2010: Sanjay Chahar; Hany Elsawy; Sergey Ragozin; Albert Jeltsch
Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution.
Journal of molecular biology 2010;395(1):79-88.
2010: Christine Champion; Dominique Guianvarc'h; Catherine Sénamaud-Beaufort; Renata Z Jurkowska; Albert Jeltsch; Loïc Ponger; Paola B Arimondo; Anne-Laure Guieysse-Peugeot
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.
PloS one 2010;5(8):e12388.
2010: Renata Z Jurkowska; Albert Jeltsch
Silencing of gene expression by targeted DNA methylation: concepts and approaches.
Methods in molecular biology (Clifton, N.J.) 2010;649():149-61.
2010: Christian Rohde; Yingying Zhang; Richard Reinhardt; Albert Jeltsch
BISMA--fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences.
BMC bioinformatics 2010;11():230.
2009: Vera Pingoud; Wolfgang Wende; Peter Friedhoff; Monika Reuter; Jürgen Alves; Albert Jeltsch; Letif Mones; Monika Fuxreiter; Alfred Pingoud
On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family.
Journal of molecular biology 2009;393(1):140-60.
2009: Hany Elsawy; Sveatoslav Podobinschi; Sanjay Chahar; Albert Jeltsch
Transition from EcoDam to T4Dam DNA recognition mechanism without loss of activity and specificity.
Chembiochem : a European journal of chemical biology 2009;10(15):2488-93.
2009: Arunkumar Dhayalan; Emilia Dimitrova; Philipp Rathert; Albert Jeltsch
A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening.
Journal of biomolecular screening 2009;14(9):1129-33.
2009: Christian Rohde; Yingying Zhang; Heinrich Stamerjohanns; Kurt Hecher; Richard Reinhardt; Albert Jeltsch
New clustering module in BDPC bisulfite sequencing data presentation and compilation web application for DNA methylation analyses.
BioTechniques 2009;47(3):781-3.
2009: Tiyu Gao; Robert E Collins; John Horton; Xing Zhang; Rongguang Zhang; Arunkumar Dhayalan; Raluca Tamas; Albert Jeltsch; Xiaodong Cheng
The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding.
Proteins 2009;76(3):772-7.
2009: Yingying Zhang; Christian Rohde; Sascha Tierling; Tomasz P Jurkowski; Christoph Bock; Diana Santacruz; Sergey Ragozin; Richard Reinhardt; Marco Groth; Jörn Walter; Albert Jeltsch
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution.
PLoS genetics 2009;5(3):e1000438.
2009: Diana V Maltseva; Alexander A Baykov; Albert Jeltsch; Elizaveta S Gromova
Impact of 7,8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a.
Biochemistry 2009;48(6):1361-8.
2009: Yingying Zhang; Christian Rohde; Richard Reinhardt; Claudia Voelcker-Rehage; Albert Jeltsch
Non-imprinted allele-specific DNA methylation on human autosomes.
Genome biology 2009;10(12):R138.
2009: Yingying Zhang; Christian Rohde; Sascha Tierling; Heinrich Stamerjohanns; Richard Reinhardt; Jörn Walter; Albert Jeltsch
DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones.
Methods in molecular biology (Clifton, N.J.) 2009;507():177-87.
2008: Philipp Rathert; Arunkumar Dhayalan; Huimin Ma; Albert Jeltsch
Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins.
Molecular bioSystems 2008;4(12):1186-90.
2008: Renata Z Jurkowska; Nils Anspach; Claus Urbanke; Da Jia; Richard Reinhardt; Wolfgang Nellen; Xiaodong Cheng; Albert Jeltsch
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.
Nucleic acids research 2008;36(21):6656-63.
2008: Albert Jeltsch
Reading and writing DNA methylation.
Nature structural & molecular biology 2008;15(10):1003-4.
2008: Albert Jeltsch; Philipp Rathert
Putting the pieces together: histone H2B ubiquitylation directly stimulates histone H3K79 methylation.
Chembiochem : a European journal of chemical biology 2008;9(14):2193-5.
2008: Tomasz P Jurkowski; Madeleine Meusburger; Sameer Phalke; Mark Helm; Wolfgang Nellen; Gunter Reuter; Albert Jeltsch
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
RNA (New York, N.Y.) 2008;14(8):1663-70.
2008: Bernardina T F van der Gun; Reinhold Wasserkort; Amélie Monami; Albert Jeltsch; Tamás Raskó; Krystyna Slaska-Kiss; Rene Cortese; Marianne G Rots; Lou F M H De Leij; Marcel H J Ruiters; Antal Kiss; Elmar Weinhold; Pamela M J McLaughlin
Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation.
International journal of cancer. Journal international du cancer 2008;123(2):484-9.
2008: Philipp Rathert; Arunkumar Dhayalan; Marie Murakami; Xing Zhang; Raluca Tamas; Renata Jurkowska; Yasuhiko Komatsu; Yoichi Shinkai; Xiaodong Cheng; Albert Jeltsch
Protein lysine methyltransferase G9a acts on non-histone targets.
Nature chemical biology 2008;4(6):344-6.
2008: Raphaël Métivier; Rozenn Gallais; Christophe Tiffoche; Christine Le Péron; Renata Z Jurkowska; Richard P Carmouche; David Ibberson; Peter Barath; Florence Demay; George Reid; Vladimir Benes; Albert Jeltsch; Frank Gannon; Gilles Salbert
Cyclical DNA methylation of a transcriptionally active promoter.
Nature 2008;452(7183):45-50.
2008: Christian Rohde; Yingying Zhang; Tomasz P Jurkowski; Heinrich Stamerjohanns; Richard Reinhardt; Albert Jeltsch
Bisulfite sequencing Data Presentation and Compilation (BDPC) web server--a useful tool for DNA methylation analysis.
Nucleic acids research 2008;36(5):e34.
2008: Arunkumar Dhayalan; Tomasz P Jurkowski; Heike Laser; Richard Reinhardt; Da Jia; Xiaodong Cheng; Albert Jeltsch
Mapping of protein-protein interaction sites by the 'absence of interference' approach.
Journal of molecular biology 2008;376(4):1091-9.
2008: Kirsten Liebert; Albert Jeltsch
Detection and quantitation of the activity of DNA methyltransferases using a biotin/avidin microplate assay.
Methods in molecular biology (Clifton, N.J.) 2008;418():149-56.
2008: Philipp Rathert; Xing Zhang; Christian Freund; Xiaodong Cheng; Albert Jeltsch
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays.
Chemistry & biology 2008;15(1):5-11.
2007: Tomasz P Jurkowski; Nils Anspach; Liliya Kulishova; Wolfgang Nellen; Albert Jeltsch
The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site.
The Journal of biological chemistry 2007;282(51):36942-52.
2007: Philipp Rathert; Xiaodong Cheng; Albert Jeltsch
Continuous enzymatic assay for histone lysine methyltransferases.
BioTechniques 2007;43(5):602, 604, 606 passim.
2007: Da Jia; Renata Z Jurkowska; Xing Zhang; Albert Jeltsch; Xiaodong Cheng
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.
Nature 2007;449(7159):248-51.
2007: Rachna Goyal; Philipp Rathert; Heike Laser; humaira gowher; Albert Jeltsch
Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1.
Epigenetics : official journal of the DNA Methylation Society 2007;2(3):155-60.
2007: Rozenn Gallais; Florence Demay; Peter Barath; Laurence Finot; Renata Z Jurkowska; Rémy Le Guével; Frédérique Gay; Albert Jeltsch; Raphaël Métivier; Gilles Salbert
Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2085-98.
2007: Kirsten Liebert; John Horton; Sanjay Chahar; Marcella Orwick; Xiaodong Cheng; Albert Jeltsch
Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle.
The Journal of biological chemistry 2007;282(31):22848-55.
2007: Albert Jeltsch; Renata Z Jurkowska; Tomasz P Jurkowski; Kirsten Liebert; Philipp Rathert; Martina Schlickenrieder
Application of DNA methyltransferases in targeted DNA methylation.
Applied microbiology and biotechnology 2007;75(6):1233-40.
2007: Philipp Rathert; Tamás Raskó; Markus Roth; Krystyna Slaska-Kiss; Alfred Pingoud; Antal Kiss; Albert Jeltsch
Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group.
Chembiochem : a European journal of chemical biology 2007;8(2):202-7.
2007: Fuyang Li; Monika Papworth; Michal Minczuk; Christian Rohde; Yingying Zhang; Sergei Ragozin; Albert Jeltsch
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
Nucleic acids research 2007;35(1):100-12.
2006: Albert Jeltsch; Jörn Walter; Richard Reinhardt; Matthias Platzer
German human methylome project started.
Cancer research 2006;66(14):7378.
2006: Albert Jeltsch; Wolfgang Nellen; Frank Lyko
Two substrates are better than one: dual specificities for Dnmt2 methyltransferases.
Trends in biochemical sciences 2006;31(6):306-8.
2006: Zheng-Hua Xie; Yan-Nv Huang; Zhao-Xia Chen; Arthur D Riggs; Jian-Ping Ding; humaira gowher; Albert Jeltsch; Hiroyuki Sasaki; Kenichiro Hata; Guo-Liang Xu
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L.
Human molecular genetics 2006;15(9):1375-85.
2006: John Horton; Kirsten Liebert; Miklos Bekes; Albert Jeltsch; Xiaodong Cheng
Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase.
Journal of molecular biology 2006;358(2):559-70.
2006: Albert Jeltsch
On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme.
Epigenetics : official journal of the DNA Methylation Society 2006;1(2):63-6.
2006: humaira gowher; Panida Loutchanwoot; Olga Vorobjeva; Vikas Handa; Renata Z Jurkowska; Tomasz P Jurkowski; Albert Jeltsch
Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase.
Journal of molecular biology 2006;357(3):928-41.
2006: Albert Jeltsch
Molecular enzymology of mammalian DNA methyltransferases.
Current topics in microbiology and immunology 2006;301():203-25.
2006: Rachna Goyal; Richard Reinhardt; Albert Jeltsch
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase.
Nucleic acids research 2006;34(4):1182-8.
2005: humaira gowher; Chris Stockdale; Rachna Goyal; Helder Ferreira; Tom Owen-Hughes; Albert Jeltsch
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases.
Biochemistry 2005;44(29):9899-904.
2005: humaira gowher; Xing Zhang; Xiaodong Cheng; Albert Jeltsch
Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase.
Analytical biochemistry 2005;342(2):287-91.
2005: Vikas Handa; Albert Jeltsch
Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome.
Journal of molecular biology 2005;348(5):1103-12.
2005: John Horton; Kirsten Liebert; Stanley Hattman; Albert Jeltsch; Xiaodong Cheng
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.
Cell 2005;121(3):349-61.
2005: humaira gowher; Kirsten Liebert; Andrea Hermann; Guoliang Xu; Albert Jeltsch
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.
The Journal of biological chemistry 2005;280(14):13341-8.
2005: Kristin Eisenschmidt; Thomas Lanio; András Simoncsits; Albert Jeltsch; Vera Pingoud; Wolfgang Wende; Alfred Pingoud
Developing a programmed restriction endonuclease for highly specific DNA cleavage.
Nucleic acids research 2005;33(22):7039-47.
2004: Andrea Hermann; Rachna Goyal; Albert Jeltsch
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites.
The Journal of biological chemistry 2004;279(46):48350-9.
2004: humaira gowher; Albert Jeltsch
Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy.
Cancer biology & therapy 2004;3(11):1062-8.
2004: Andrea Hermann; humaira gowher; Albert Jeltsch
Biochemistry and biology of mammalian DNA methyltransferases.
Cellular and molecular life sciences : CMLS 2004;61(19-20):2571-87.
2004: Vikas Handa; Albert Jeltsch
Anomalous mobility of polymerase chain reaction products after bisulfite treatment of DNA.
Analytical biochemistry 2004;333(1):196-8.
2004: Kirsten Liebert; Andrea Hermann; Martina Schlickenrieder; Albert Jeltsch
Stopped-flow and mutational analysis of base flipping by the Escherichia coli Dam DNA-(adenine-N6)-methyltransferase.
Journal of molecular biology 2004;341(2):443-54.
2004: Ying-Zi Ge; Min-Tie Pu; humaira gowher; Hai-Ping Wu; Jian-Ping Ding; Albert Jeltsch; Guo-Liang Xu
Chromatin targeting of de novo DNA methyltransferases by the PWWP domain.
The Journal of biological chemistry 2004;279(24):25447-54.
2003: Albert Jeltsch
Maintenance of species identity and controlling speciation of bacteria: a new function for restriction/modification systems?
Gene 2003;317(1-2):13-6.
2003: Andrea Hermann; Sigrid Schmitt; Albert Jeltsch
The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.
The Journal of biological chemistry 2003;278(34):31717-21.
2003: Aspasia Spyridaki; Claudia Matzen; Thomas Lanio; Albert Jeltsch; András Simoncsits; Alekos Athanasiadis; Eva Scheuring-Vanamee; Michael Kokkinidis; Alfred Pingoud
Structural and biochemical characterization of a new Mg(2+) binding site near Tyr94 in the restriction endonuclease PvuII.
Journal of molecular biology 2003;331(2):395-406.
2003: Sabine Reither; Fuyang Li; humaira gowher; Albert Jeltsch
Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme.
Journal of molecular biology 2003;329(4):675-84.
2003: Andrea Hermann; Albert Jeltsch
Methylation sensitivity of restriction enzymes interacting with GATC sites.
BioTechniques 2003;34(5):924-6, 928, 930.
2003: Richard J Roberts; Marlene Belfort; Timothy Bestor; Ashok S Bhagwat; Thomas A Bickle; Jurate Bitinaite; Robert Blumenthal; Sergey Kh Degtyarev; David T F Dryden; Kevin Dybvig; Keith Firman; Elizaveta S Gromova; Richard I Gumport; Stephen E Halford; Stanley Martin Hattman; Joseph Heitman; David P Hornby; Arvydas Janulaitis; Albert Jeltsch; Jytte Josephsen; Antal Kiss; Todd R Klaenhammer; Ichizo Kobayashi; Huimin Kong; Detlev H Krüger; Sanford Lacks; Martin G Marinus; Michiko Miyahara; Richard D Morgan; Noreen E Murray; Valakunja Nagaraja; Andrzej Piekarowicz; Alfred Pingoud; Elisabeth Raleigh; Desirazu N Rao; Norbert Reich; Vladimir Repin; Eric U Selker; Pang-Chui Shaw; Daniel C. Stein; Barry L Stoddard; Waclaw Szybalski; Thomas A Trautner; James L Van Etten; Jorge M B Vitor; Geoffrey G Wilson; Shuang-yong Xu
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
Nucleic acids research 2003;31(7):1805-12.
2003: Andreas Humeny; Carsten Beck; Cord-Michael Becker; Albert Jeltsch
Detection and analysis of enzymatic DNA methylation of oligonucleotide substrates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
Analytical biochemistry 2003;313(1):160-6.
2003: Thomas Lanio; Albert Jeltsch; Alfred Pingoud
High-throughput purification of polyHis-tagged recombinant fusion proteins.
Methods in molecular biology (Clifton, N.J.) 2003;205():199-203.
2002: Carsten Beck; Albert Jeltsch
Probing the DNA interface of the EcoRV DNA-(adenine-N6)-methyltransferase by site-directed mutagenesis, fluorescence spectroscopy, and UV cross-linking.
Biochemistry 2002;41(48):14103-10.
2002: Mehrnaz Fatemi; Andrea Hermann; humaira gowher; Albert Jeltsch
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA.
European journal of biochemistry / FEBS 2002;269(20):4981-4.
2002: Kristin Eisenschmidt; Thomas Lanio; Albert Jeltsch; Alfred Pingoud
A fluorimetric assay for on-line detection of DNA cleavage by restriction endonucleases.
Journal of biotechnology 2002;96(2):185-91.
2002: Sabine Urig; humaira gowher; Andrea Hermann; Carsten Beck; Mehrnaz Fatemi; Andeas Humeny; Albert Jeltsch
The Escherichia coli dam DNA methyltransferase modifies DNA in a highly processive reaction.
Journal of molecular biology 2002;319(5):1085-96.
2002: humaira gowher; Albert Jeltsch
Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases.
The Journal of biological chemistry 2002;277(23):20409-14.
2002: Albert Jeltsch
Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases.
Chembiochem : a European journal of chemical biology 2002;3(4):274-93.
2002: Sabine Reither; Albert Jeltsch
Specificity of DNA triple helix formation analyzed by a FRET assay.
BMC biochemistry 2002;3():27.
2002: Albert Jeltsch; Thomas Lanio
Site-directed mutagenesis by polymerase chain reaction.
Methods in molecular biology (Clifton, N.J.) 2002;182():85-94.
2001: humaira gowher; Kenneth Ehrlich; Albert Jeltsch
DNA from Aspergillus flavus contains 5-methylcytosine.
FEMS microbiology letters 2001;205(1):151-5.
2001: Carsten Beck; S Cranz; M Solmaz; M Roth; Albert Jeltsch
How does a DNA interacting enzyme change its specificity during molecular evolution? A site-directed mutagenesis study at the DNA binding site of the DNA-(adenine-N6)-methyltransferase EcoRV.
Biochemistry 2001;40(37):10956-65.
2001: Alfred Pingoud; Albert Jeltsch
Structure and function of type II restriction endonucleases.
Nucleic acids research 2001;29(18):3705-27.
2001: M Roth; Albert Jeltsch
Changing the target base specificity of the EcoRV DNA methyltransferase by rational de novo protein-design.
Nucleic acids research 2001;29(15):3137-44.
2001: humaira gowher; Albert Jeltsch
Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites.
Journal of molecular biology 2001;309(5):1201-8.
2001: Mehrnaz Fatemi; Andrea Hermann; S Pradhan; Albert Jeltsch
The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA.
Journal of molecular biology 2001;309(5):1189-99.
2001: Albert Jeltsch
The cytosine N4-methyltransferase M.PvuII also modifies adenine residues.
Biological chemistry 2001;382(4):707-10.
2001: Albert Jeltsch; Alfred Pingoud
Methods for determining activity and specificity of DNA binding and DNA cleavage by class II restriction endonucleases.
Methods in molecular biology (Clifton, N.J.) 2001;160():287-308.
2000: humaira gowher; Oliver Leismann; Albert Jeltsch
DNA of Drosophila melanogaster contains 5-methylcytosine.
The EMBO journal 2000;19(24):6918-23.
2000: humaira gowher; Albert Jeltsch
Molecular enzymology of the EcoRV DNA-(Adenine-N (6))-methyltransferase: kinetics of DNA binding and bending, kinetic mechanism and linear diffusion of the enzyme on DNA.
Journal of molecular biology 2000;303(1):93-110.
2000: Thomas Lanio; Albert Jeltsch; Alfred Pingoud
Automated purification of His6-tagged proteins allows exhaustive screening of libraries generated by random mutagenesis.
BioTechniques 2000;29(2):338-42.
2000: T Friedrich; M Fatemi; H Gowhar; Oliver Leismann; Albert Jeltsch
Specificity of DNA binding and methylation by the M.FokI DNA methyltransferase.
Biochimica et biophysica acta 2000;1480(1-2):145-59.
2000: Thomas Lanio; Albert Jeltsch; Alfred Pingoud
On the possibilities and limitations of rational protein design to expand the specificity of restriction enzymes: a case study employing EcoRV as the target.
Protein engineering 2000;13(4):275-81.
2000: M Roth; Albert Jeltsch
Biotin-avidin microplate assay for the quantitative analysis of enzymatic methylation of DNA by DNA methyltransferases.
Biological chemistry 2000;381(3):269-72.
1999: Albert Jeltsch; F Christ; Mehrnaz Fatemi; M Roth
On the substrate specificity of DNA methyltransferases. adenine-N6 DNA methyltransferases also modify cytosine residues at position N4.
The Journal of biological chemistry 1999;274(28):19538-44.
1999: Albert Jeltsch
Circular permutations in the molecular evolution of DNA methyltransferases.
Journal of molecular evolution 1999;49(1):161-4.
1999: Giedrius Sasnauskas; Albert Jeltsch; Alfred Pingoud; Virginijus Siksnys
Plasmid DNA cleavage by MunI restriction enzyme: single-turnover and steady-state kinetic analysis.
Biochemistry 1999;38(13):4028-36.
1999: Albert Jeltsch; M Roth; T Friedrich
Mutational analysis of target base flipping by the EcoRV adenine-N6 DNA methyltransferase.
Journal of molecular biology 1999;285(3):1121-30.
1998: Thomas Lanio; Albert Jeltsch
PCR-based random mutagenesis method using spiked oligonucleotides to randomize selected parts of a gene without any wild-type background.
BioTechniques 1998;25(6):958, 962-5.
1998: C Schulze; Albert Jeltsch; I Franke; Claus Urbanke; Alfred Pingoud
Crosslinking the EcoRV restriction endonuclease across the DNA-binding site reveals transient intermediates and conformational changes of the enzyme during DNA binding and catalytic turnover.
The EMBO journal 1998;17(22):6757-66.
1998: S Schöttler; C Wenz; Thomas Lanio; Albert Jeltsch; Alfred Pingoud
Protein engineering of the restriction endonuclease EcoRV--structure-guided design of enzyme variants that recognize the base pairs flanking the recognition site.
European journal of biochemistry / FEBS 1998;258(1):184-91.
1998: Albert Jeltsch
Flexibility of DNA in complex with proteins deduced from the distribution of bending angles observed by scanning force microscopy.
Biophysical chemistry 1998;74(1):53-7.
1998: M Roth; S Helm-Kruse; T Friedrich; Albert Jeltsch
Functional roles of conserved amino acid residues in DNA methyltransferases investigated by site-directed mutagenesis of the EcoRV adenine-N6-methyltransferase.
The Journal of biological chemistry 1998;273(28):17333-42.
1998: F Stahl; Wolfgang Wende; C Wenz; Albert Jeltsch; Alfred Pingoud
Intra- vs intersubunit communication in the homodimeric restriction enzyme EcoRV: Thr 37 and Lys 38 involved in indirect readout are only important for the catalytic activity of their own subunit.
Biochemistry 1998;37(16):5682-8.
1998: T Friedrich; M Roth; S Helm-Kruse; Albert Jeltsch
Functional mapping of the EcoRV DNA methyltransferase by random mutagenesis and screening for catalytically inactive mutants.
Biological chemistry 1998;379(4-5):475-80.
1998: F Stahl; Wolfgang Wende; Albert Jeltsch; Alfred Pingoud
The mechanism of DNA cleavage by the type II restriction enzyme EcoRV: Asp36 is not directly involved in DNA cleavage but serves to couple indirect readout to catalysis.
Biological chemistry 1998;379(4-5):467-73.
1998: Albert Jeltsch; Alfred Pingoud
Kinetic characterization of linear diffusion of the restriction endonuclease EcoRV on DNA.
Biochemistry 1998;37(8):2160-9.
1998: Albert Jeltsch; T Friedrich; M Roth
Kinetics of methylation and binding of DNA by the EcoRV adenine-N6 methyltransferase.
Journal of molecular biology 1998;275(5):747-58.
1998: Oliver Leismann; M Roth; T Friedrich; Wolfgang Wende; Albert Jeltsch
The Flavobacterium okeanokoites adenine-N6-specific DNA-methyltransferase M.FokI is a tandem enzyme of two independent domains with very different kinetic properties.
European journal of biochemistry / FEBS 1998;251(3):899-906.
1998: Thomas Lanio; Albert Jeltsch; Alfred Pingoud
Towards the design of rare cutting restriction endonucleases: using directed evolution to generate variants of EcoRV differing in their substrate specificity by two orders of magnitude.
Journal of molecular biology 1998;283(1):59-69.
1997: Detlef H Groll; Albert Jeltsch; U Selent; Alfred Pingoud
Does the restriction endonuclease EcoRV employ a two-metal-Ion mechanism for DNA cleavage?
Biochemistry 1997;36(38):11389-401.
1997: Alfred Pingoud; Albert Jeltsch
Recognition and cleavage of DNA by type-II restriction endonucleases.
European journal of biochemistry / FEBS 1997;246(1):1-22.
1996: Albert Jeltsch; C Wenz; F Stahl; Alfred Pingoud
Linear diffusion of the restriction endonuclease EcoRV on DNA is essential for the in vivo function of the enzyme.
The EMBO journal 1996;15(18):5104-11.
1996: Albert Jeltsch; C Wenz; Wolfgang Wende; U Selent; Alfred Pingoud
Engineering novel restriction endonucleases: principles and applications.
Trends in biotechnology 1996;14(7):235-8.
1996: F Stahl; Wolfgang Wende; Albert Jeltsch; Alfred Pingoud
Introduction of asymmetry in the naturally symmetric restriction endonuclease EcoRV to investigate intersubunit communication in the homodimeric protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):6175-80.
1996: Albert Jeltsch; T Sobotta; Alfred Pingoud
Structure prediction of the EcoRV DNA methyltransferase based on mutant profiling, secondary structure analysis, comparison with known structures of methyltransferases and isolation of catalytically inactive single mutants.
Protein engineering 1996;9(5):413-23.
1996: C Wenz; Albert Jeltsch; Alfred Pingoud
Probing the indirect readout of the restriction enzyme EcoRV. Mutational analysis of contacts to the DNA backbone.
The Journal of biological chemistry 1996;271(10):5565-73.
1996: Albert Jeltsch; Alfred Pingoud
Horizontal gene transfer contributes to the wide distribution and evolution of type II restriction-modification systems.
Journal of molecular evolution 1996;42(2):91-6.
1995: Albert Jeltsch; M Kröger; Alfred Pingoud
Evidence for an evolutionary relationship among type-II restriction endonucleases.
Gene 1995;160(1):7-16.
1995: Albert Jeltsch; M Pleckaityte; U Selent; Heiner Wolfes; Virginijus Siksnys; Alfred Pingoud
Evidence for substrate-assisted catalysis in the DNA cleavage of several restriction endonucleases.
Gene 1995;157(1-2):157-62.
1995: G Grabowski; Albert Jeltsch; Heiner Wolfes; G Maass; Jürgen Alves
Site-directed mutagenesis in the catalytic center of the restriction endonuclease EcoRI.
Gene 1995;157(1-2):113-8.
1995: Albert Jeltsch; H Maschke; U Selent; C Wenz; E Köhler; Bernard A Connolly; H Thorogood; Alfred Pingoud
DNA binding specificity of the EcoRV restriction endonuclease is increased by Mg2+ binding to a metal ion binding site distinct from the catalytic center of the enzyme.
Biochemistry 1995;34(18):6239-46.
1995: Albert Jeltsch; Jürgen Alves; Claus Urbanke; G Maass; H Eckstein; Z Lianshan; E Bayer; Alfred Pingoud
A dodecapeptide comprising the extended chain-alpha 4 region of the restriction endonuclease EcoRI specifically binds to the EcoRI recognition site.
The Journal of biological chemistry 1995;270(10):5122-9.
1994: C Wenz; U Selent; Wolfgang Wende; Albert Jeltsch; Heiner Wolfes; Alfred Pingoud
Protein engineering of the restriction endonuclease EcoRV: replacement of an amino acid residue in the DNA binding site leads to an altered selectivity towards unmodified and modified substrates.
Biochimica et biophysica acta 1994;1219(1):73-80.
1994: Albert Jeltsch; Jürgen Alves; Heiner Wolfes; G Maass; Alfred Pingoud
Pausing of the restriction endonuclease EcoRI during linear diffusion on DNA.
Biochemistry 1994;33(34):10215-9.
1993: Albert Jeltsch; Jürgen Alves; Heiner Wolfes; G Maass; Alfred Pingoud
Substrate-assisted catalysis in the cleavage of DNA by the EcoRI and EcoRV restriction enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8499-503.
1993: Albert Jeltsch; A Fritz; Jürgen Alves; Heiner Wolfes; Alfred Pingoud
A fast and accurate enzyme-linked immunosorbent assay for the determination of the DNA cleavage activity of restriction endonucleases.
Analytical biochemistry 1993;213(2):234-40.
1993: Albert Jeltsch; Jürgen Alves; Thomas Oelgeschläger; Heiner Wolfes; G Maass; Alfred Pingoud
Mutational analysis of the function of Gln115 in the EcoRI restriction endonuclease, a critical amino acid for recognition of the inner thymidine residue in the sequence -GAATTC- and for coupling specific DNA binding to catalysis.
Journal of molecular biology 1993;229(1):221-34.
1992: Albert Jeltsch; Jürgen Alves; G Maass; Alfred Pingoud
On the catalytic mechanism of EcoRI and EcoRV. A detailed proposal based on biochemical results, structural data and molecular modelling.
FEBS letters 1992;304(1):4-8.