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Declan McLoughlin

Research Profile

Chemicals & Drugs

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Alzheimer's Disease

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C Manser; Declan McLoughlin; A Vagnoni; J Davies; Kurt J De Vos; F Guillot; Kwok-Fai Lau; C C J Miller
Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.
Yan Hao; Ka-Ho Chai; Ho Yin Edwin Chan; Declan McLoughlin; Kwok-Fai Lau
Promoter characterization and genomic organization of the human X11β gene APBA2.
Kwok-Fai Lau; Michael S Perkinton; Lilia Rodriguez; Declan McLoughlin; Christopher C J Miller
An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

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All Publications

2012: C Manser; Declan McLoughlin; A Vagnoni; J Davies; Kurt J De Vos; F Guillot; Kwok-Fai Lau; C C J Miller
Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.
Oncogene 2012;31(22):2773-82.
2012: Yan Hao; Ka-Ho Chai; Ho Yin Edwin Chan; Declan McLoughlin; Kwok-Fai Lau
Promoter characterization and genomic organization of the human X11β gene APBA2.
Neuroreport 2012;23(3):146-51.
2010: Kwok-Fai Lau; Michael S Perkinton; Lilia Rodriguez; Declan McLoughlin; Christopher C J Miller
An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
Neuroreport 2010;21(11):761-6.
2010: E L Tudor; C M Galtrey; Michael S Perkinton; Kwok-Fai Lau; Kurt J De Vos; J C Mitchell; Steven Ackerley; Tibor Hortobágyi; E Vámos; P Nigel Leigh; C Klasen; Declan McLoughlin; Christopher Shaw; C C J Miller
Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
Neuroscience 2010;167(3):774-85.
2010: D K Tracy; O O'Daly; D W Joyce; P G Michalopoulou; B B Basit; G Dhillon; Declan McLoughlin; Sukhwinder S Shergill
An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.
Neuropsychologia 2010;48(1):270-7.
2009: Jacqueline C Mitchell; Belall B Ariff; Darran M Yates; Kwok-Fai Lau; Michael S Perkinton; Boris Rogelj; John D Stephenson; Christopher C J Miller; Declan McLoughlin
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
Human molecular genetics 2009;18(23):4492-500.
2009: Declan McLoughlin
Review: high frequency repetitive transcranial magnetic stimulation improves symptoms of major depression.
Evidence-based mental health 2009;12(3):80-1.
2009: Alison Stevenson; Darran M Yates; Catherine Manser; Kurt J De Vos; Alessio Vagnoni; P Nigel Leigh; Declan McLoughlin; Christopher C J Miller
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.
Neuroscience letters 2009;454(2):161-4.
2009: Darran M Yates; Catherine Manser; Kurt J De Vos; Christopher Shaw; Declan McLoughlin; Christopher C J Miller
Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.
European journal of cell biology 2009;88(4):193-202.
2009: Savithasri V Eranti; Andrew Mogg; Graham Pluck; Sabine Landau; Declan McLoughlin
Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: a naturalistic comparison study.
Journal of affective disorders 2009;113(1-2):165-71.
2009: Timothy Richard Joseph Nicholson; Carmine Pariante; Declan McLoughlin
Stendhal syndrome: a case of cultural overload.
BMJ case reports 2009;2009():.
2008: Kwok-Fai Lau; Wing-Man Chan; Michael S Perkinton; Elizabeth L Tudor; Raymond Chuen-Chung Chang; H Y Edwin Chan; Declan McLoughlin; Christopher C J Miller
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
The Journal of biological chemistry 2008;283(50):34728-37.
2008: Martin Knapp; Renee Romeo; Andrew Mogg; Savithasri V Eranti; Graham Pluck; Rick Purvis; Richard Brown; Robert Howard; Michael Philpot; John C Rothwell; Denzil Edwards; Declan McLoughlin
Cost-effectiveness of transcranial magnetic stimulation vs. electroconvulsive therapy for severe depression: a multi-centre randomised controlled trial.
Journal of affective disorders 2008;109(3):273-85.
2008: Catherine Manser; Alison Stevenson; Steven Banner; Jennifer Davies; Elizabeth L Tudor; Yoshitaka Ono; P Nigel Leigh; Declan McLoughlin; Christopher Shaw; Christopher C J Miller
Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.
FEBS letters 2008;582(15):2303-8.
2008: Declan McLoughlin
Vagus rules still apply.
Psychological medicine 2008;38(5):625-7.
2008: Andrew Mogg; Graham Pluck; Savithasri V Eranti; Sabine Landau; Rick Purvis; Richard Brown; V Curtis; Robert Howard; Michael Philpot; Declan McLoughlin
A randomized controlled trial with 4-month follow-up of adjunctive repetitive transcranial magnetic stimulation of the left prefrontal cortex for depression.
Psychological medicine 2008;38(3):323-33.
2008: Declan McLoughlin; Christopher C J Miller
The FE65 proteins and Alzheimer's disease.
Journal of neuroscience research 2008;86(4):744-54.
2007: Kurt J De Vos; Anna L Chapman; Maria E Tennant; Catherine Manser; Elizabeth L Tudor; Kwok-Fai Lau; Janet Brownlees; Steven Ackerley; Pamela J Shaw; Declan McLoughlin; Christopher Shaw; P Nigel Leigh; Christopher C J Miller; andy grierson
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
Human molecular genetics 2007;16(22):2720-8.
2007: Declan McLoughlin; Andrew Mogg; Savithasri V Eranti; Graham Pluck; Rick Purvis; D Edwards; Sabine Landau; R Brown; S Rabe-Heskith; Robert Howard; Michael Philpot; John C Rothwell; R Romeo; Martin Knapp
The clinical effectiveness and cost of repetitive transcranial magnetic stimulation versus electroconvulsive therapy in severe depression: a multicentre pragmatic randomised controlled trial and economic analysis.
Health technology assessment (Winchester, England) 2007;11(24):1-54.
2007: Andrew Mogg; Rick Purvis; Savithasri V Eranti; Faith Contell; John P Taylor; Timothy Nicholson; Richard Brown; Declan McLoughlin
Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: a randomized controlled pilot study.
Schizophrenia research 2007;93(1-3):221-8.
2007: Savithasri V Eranti; Andrew Mogg; Graham Pluck; Sabine Landau; Rick Purvis; Richard Brown; Robert Howard; Martin Knapp; Michael Philpot; Sophia Rabe-Hesketh; Renee Romeo; John C Rothwell; Denzil Edwards; Declan McLoughlin
A randomized, controlled trial with 6-month follow-up of repetitive transcranial magnetic stimulation and electroconvulsive therapy for severe depression.
The American journal of psychiatry 2007;164(1):73-81.
2006: Boris Rogelj; Jacqueline C Mitchell; Christopher C J Miller; Declan McLoughlin
The X11/Mint family of adaptor proteins.
Brain research reviews 2006;52(2):305-15.
2006: Christopher C J Miller; Declan McLoughlin; Kwok-Fai Lau; Maria E Tennant; Boris Rogelj
The X11 proteins, Abeta production and Alzheimer's disease.
Trends in neurosciences 2006;29(5):280-5.
2005: Rudolf Uher; Daniella Yoganathan; Andrew Mogg; Savithasri V Eranti; Janet Treasure; Iain C Campbell; Declan McLoughlin; Ulrike Schmidt
Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving.
Biological psychiatry 2005;58(10):840-2.
2005: Elizabeth L Tudor; Michael S Perkinton; Anja Schmidt; Steven Ackerley; Janet Brownlees; Nicholas J O Jacobsen; Helen L Byers; Malcolm Ward; Alan Hall; P Nigel Leigh; Christopher Shaw; Declan McLoughlin; Christopher C J Miller
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
The Journal of biological chemistry 2005;280(41):34735-40.
2005: Yann S Mineur; Declan McLoughlin; Wim E Crusio; Frans Sluyter
Genetic mouse models of Alzheimer's disease.
Neural plasticity 2005;12(4):299-310.
2004: Ju-Hyun Lee; Kwok-Fai Lau; Michael S Perkinton; Claire L Standen; Boris Rogelj; Agnieszka Falinska; Declan McLoughlin; Christopher C J Miller
The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
The Journal of biological chemistry 2004;279(47):49099-104.
2004: Michael S Perkinton; Claire L Standen; Kwok-Fai Lau; Sashi Kesavapany; Helen L Byers; Malcolm Ward; Declan McLoughlin; Christopher C J Miller
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
The Journal of biological chemistry 2004;279(21):22084-91.
2003: Claire L Standen; Michael S Perkinton; Helen L Byers; Sashi Kesavapany; Kwok-Fai Lau; Malcolm Ward; Declan McLoughlin; Christopher C J Miller
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).
Molecular and cellular neurosciences 2003;24(4):851-7.
2003: Ju-Hyun Lee; Kwok-Fai Lau; Michael S Perkinton; Claire L Standen; Stephen J A Shemilt; Luc Mercken; Jonathan D Cooper; Declan McLoughlin; Christopher C J Miller
The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
The Journal of biological chemistry 2003;278(47):47025-9.
2003: Declan McLoughlin
Review: repetitive transcranial magnetic stimulation is of unknown effectiveness in people with depression.
Evidence-based mental health 2003;6(4):118.
2003: Sashi Kesavapany; Kwok-Fai Lau; Steven Ackerley; Steve Banner; Stephen J A Shemilt; Jonathan D Cooper; P Nigel Leigh; Christopher Shaw; Declan McLoughlin; Christopher C J Miller
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(12):4975-83.
2003: Savithasri V Eranti; Declan McLoughlin
Electroconvulsive therapy - state of the art.
The British journal of psychiatry : the journal of mental science 2003;182():8-9.
2002: Brendan D Kelly; Declan McLoughlin
Euthanasia, assisted suicide and psychiatry: a Pandora's box.
The British journal of psychiatry : the journal of mental science 2002;181():278-9.
2002: Kwok-Fai Lau; David R Howlett; Sashi Kesavapany; Claire L Standen; Colin Dingwall; Declan McLoughlin; Christopher C J Miller
Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
Molecular and cellular neurosciences 2002;20(1):13-20.
2002: Simon Lovestone; Declan McLoughlin
Protein aggregates and dementia: is there a common toxicity?
Journal of neurology, neurosurgery, and psychiatry 2002;72(2):152-61.
2002: Sashi Kesavapany; Steve Banner; Kwok-Fai Lau; Christopher Shaw; Christopher C J Miller; Jonathan D Cooper; Declan McLoughlin
Expression of the Fe65 adapter protein in adult and developing mouse brain.
Neuroscience 2002;115(3):951-60.
2001: D Lyons; Declan McLoughlin
Recent advances: Psychiatry.
BMJ (Clinical research ed.) 2001;323(7323):1228-31.
2001: Declan McLoughlin; Claire L Standen; Kwok-Fai Lau; Steven Ackerley; T P Bartnikas; J D Gitlin; Christopher C J Miller
The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity.
The Journal of biological chemistry 2001;276(12):9303-7.
2001: Sashi Kesavapany; Kwok-Fai Lau; Declan McLoughlin; Janet Brownlees; Steven Ackerley; P Nigel Leigh; Christopher Shaw; Christopher C J Miller
p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction.
The European journal of neuroscience 2001;13(2):241-7.
2001: Claire L Standen; Janet Brownlees; andy grierson; Sashi Kesavapany; Kwok-Fai Lau; Declan McLoughlin; Christopher C J Miller
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).
Journal of neurochemistry 2001;76(1):316-20.
2000: Kwok-Fai Lau; Declan McLoughlin; Claire L Standen; NG Irving; Christopher C J Miller
Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein.
Neuroreport 2000;11(16):3607-10.
2000: Kwok-Fai Lau; Declan McLoughlin; Claire L Standen; Christopher C J Miller
X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.
Molecular and cellular neurosciences 2000;16(5):557-65.
2000: Declan McLoughlin; W S Wassif; J Morton; E Spargo; T J Peters; GF Russell
Metabolic abnormalities associated with skeletal myopathy in severe anorexia nervosa.
Nutrition (Burbank, Los Angeles County, Calif.) 2000;16(3):192-6.
1999: J Morton; Declan McLoughlin; S Whiting; GF Russell
Carnitine levels in patients with skeletal myopathy due to anorexia nervosa before and after refeeding.
The International journal of eating disorders 1999;26(3):341-4.
1999: Declan McLoughlin; NG Irving; Janet Brownlees; Jean-Pierre Brion; Karelle Leroy; Christopher C J Miller
Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease.
The European journal of neuroscience 1999;11(6):1988-94.
1998: Declan McLoughlin; NG Irving; Christopher C J Miller
The Fe65 and X11 families of proteins: proteins that interact with the Alzheimer's disease amyloid precursor protein.
Biochemical Society transactions 1998;26(3):497-500.
1998: Declan McLoughlin; E Spargo; W S Wassif; D J Newham; T J Peters; P L Lantos; GF Russell
Structural and functional changes in skeletal muscle in anorexia nervosa.
Acta neuropathologica 1998;95(6):632-40.
1998: G Blanco; NG Irving; Steve D M Brown; Christopher C J Miller; Declan McLoughlin
Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(6):473-5.
1998: S Guidato; Declan McLoughlin; andy grierson; Christopher C J Miller
Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity.
Journal of neurochemistry 1998;70(1):335-40.
1996: C Holmes; R Levy; Declan McLoughlin; J F Powell; Simon Lovestone
Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 1996;61(6):580-3.
1996: Declan McLoughlin; Christopher C J Miller
The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system.
FEBS letters 1996;397(2-3):197-200.
1996: Declan McLoughlin; C Cooney; C Holmes; R Levy
Carer informants for dementia sufferers: carer awareness of cognitive impairment in an elderly community-resident sample.
Age and ageing 1996;25(5):367-71.
1996: Declan McLoughlin; R Levy
The differential diagnosis of dementia.
Acta neurologica Scandinavica. Supplementum 1996;165():92-100.
1994: Declan McLoughlin; J V Lucey; Timothy G Dinan
Central serotonergic hyperresponsivity in late-onset Alzheimer's disease.
The American journal of psychiatry 1994;151(11):1701-3.
1992: V O'Keane; Declan McLoughlin; Timothy G Dinan
D-fenfluramine-induced prolactin and cortisol release in major depression: response to treatment.
Journal of affective disorders 1992;26(3):143-50.
1991: Declan McLoughlin; P McKeon
Bipolar disorder and cerebral sarcoidosis.
The British journal of psychiatry : the journal of mental science 1991;158():410-3.