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Scott Franzblau

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Feng Qiu; Geping Cai; Scott Franzblau; Birgit U Jaki; David C Lankin; Guido F Pauli
Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.
Raúl E Juárez-Hernández; Scott Franzblau; Marvin J Miller
Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis.
Taichi Inui; Samuel M Pro; Yuehong Wang; Scott Franzblau; Guido F Pauli
Unbiased evaluation of bioactive secondary metabolites in complex matrices.

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2013: Feng Qiu; Geping Cai; Scott Franzblau; Birgit U Jaki; David C Lankin; Guido F Pauli
Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.
Journal of natural products 2013;76(3):413-9.
2012: Raúl E Juárez-Hernández; Scott Franzblau; Marvin J Miller
Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis.
Organic & biomolecular chemistry 2012;10(37):7584-93.
2012: Taichi Inui; Samuel M Pro; Yuehong Wang; Scott Franzblau; Guido F Pauli
Unbiased evaluation of bioactive secondary metabolites in complex matrices.
Fitoterapia 2012;83(7):1218-25.
2012: Hyunjung Kim; David J Kroll; Daniel D Lantvit; Scott Franzblau; Chang Hwa Hwang; Steven M Swanson; Jimmy Orjala
Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola.
Bioorganic & medicinal chemistry 2012;20(17):5290-5.
2012: Dominique L Kunciw; Jacob J Liechty; Miguel O Mitchell; Baojie Wan; Scott Franzblau
Structural requirements for the antitubercular quaternized triflupromazine pharmacophore.
Bioorganic & medicinal chemistry letters 2012;22(17):5679-80.
2012: Balakrishna Dulla; Scott Franzblau; Javed Iqbal; Ravikumar Kapavarapu; Oliver Reiser; Baojie Wan; Manojit Pal
Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents.
Bioorganic & medicinal chemistry letters 2012;22(14):4629-35.
2012: Sidharth Chopra; Rupa S Doppalapudi; Scott Franzblau; Carol E Green; Lalitha V Iyer; Gary A Koolpe; Karen N Matsuyama; Edward S Riccio; Kenneth J Ryan; Arlyn A Tambo-Ong; Tran B Tran; Baojie Wan; Peter B Madrid
Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.
Journal of medicinal chemistry 2012;55(13):6047-60.
2012: Murali Kumarasamy; Scott Franzblau; Rousso Govindarajan; Panneerselvam Theivendren; Kirthiga Ramalingam
Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives.
Journal of pharmacy & bioallied sciences 2012;4(3):207-11.
2012: Allan Patrick G Macabeo; Grecebio Jonathan D Alejandro; Jalil A Avila; Scott Franzblau; Hidayat Hussain; Simeon F Kouam; Karsten Krohn
Villarinol, a new alkenoyloxyalkenol derivative from the endemic Philippine Rubiaceae species Villaria odorata.
Natural product communications 2012;7(6):779-80.
2012: Allan Patrick G Macabeo; Scott Franzblau; Dietmar Gehle; Karsten Krohn; Alicia M Aguinaldo
Photoactivated [3+2] addition of 6,7-seco-angustilobine B to fullerene [C60].
Natural product communications 2012;7(6):743-5.
2012: Cheng Ji; Weimin Lin; Scott Franzblau; Ute Möllmann; Garrett C Moraski; Michael J Pucci; Jane A Thanassi; Marvin J Miller
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.
Bioorganic & medicinal chemistry 2012;20(11):3422-8.
2012: Dipti Shingnapurkar; Ekk Sinn; K Venkateswara Swamy; Shital Pandit; Annie K Powell; Zahra Afrasiabi; Christopher E Anson; Prasad Dandawate; Scott Franzblau; Subhash Padhye
Synthesis and characterization of pyruvate-isoniazid analogs and their copper complexes as potential ICL inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(9):3172-6.
2012: Sumandeep K Gill; Paul D Kirchhoff; Kuan-Wei Peng; Anjanette J Turbiak; Baojie Wan; Hao Xu; Nan Zhang; Tomasz Cierpicki; Scott Franzblau; George A Garcia; H D Hollis Showalter
Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases.
Journal of medicinal chemistry 2012;55(8):3814-26.
2012: Joy Debnath; Scott Franzblau; Anne J Lenaerts; Shajila Siricilla; Bajoie Wan; Dean Crick; Michio Kurosu
Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis.
Journal of medicinal chemistry 2012;55(8):3739-55.
2012: Garrett C Moraski; Helena I Boshoff; Mayland Chang; Sanghyun Cho; Scott Franzblau; Chang Hwa Hwang; Lowell D Markley; Marvin J Miller
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.
Bioorganic & medicinal chemistry 2012;20(7):2214-20.
2012: Xiaoyun Lu; Baojie Wan; Lili Chen; Scott Franzblau; Xiaobo Liu; Changlin Zhou; Qidong You
Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2.
European journal of medicinal chemistry 2012;49():164-71.
2012: Sidharth Chopra; Haidan Guo; Tran Tran; Scott Franzblau; Karen Matsuyama; Baojie Wan; Shichun Lun; Jeremiah P Malerich; William R Bishai; Mariama C Maiga; Peter B Madrid
Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy 2012;67(2):415-21.
2012: Adrian Blaser; Iveta Kmentova; Brian D Palmer; Zhenkun Ma; Scott Franzblau; Baojie Wan; Hamish S Sutherland; Andrew M Thompson; Yuehong Wang; William A Denny
Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Journal of medicinal chemistry 2012;55(1):312-26.
2012: Annamaria Lilienkampf; Marco Pieroni; William R Bishai; Scott Franzblau; Alan P Kozikowski
Derivatives of 3-isoxazolecarboxylic acid esters: a potent and selective compound class against replicating and nonreplicating Mycobacterium tuberculosis.
Current topics in medicinal chemistry 2012;12(7):729-34.
2012: Charlotte Gyllenhaal; K Sydara; P Tamez; N T Hiep; M R Kadushin; B G Elkington; J M Pezzuto; C Y Ma; S Bouamanivong; H M Ly; H T Nguyen; L X Dac; Hui Xie; M Xaiveu; T Q Bich; B Southavong; N V Hung; M C Riley; Hong-Jie Zhang; Donald Paul Waller; G T Tan; N M Cuong; P K Loc; L T Xuan; Scott Franzblau; D Doel Soejarto
Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis.
Pharmaceutical biology 2012;50(1):30-41.
2012: D Doel Soejarto; M Xaiveu; S Bouamanivong; M C Riley; Scott Franzblau; B G Elkington; Ghee T Tan; K Sydara; J M Pezzuto; H-J Zhang; Charlotte Gyllenhaal; B Southavong; M R Kadushin; Donald Paul Waller
An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development.
Pharmaceutical biology 2012;50(1):42-60.
2012: Temitope O Lawal; Aremu O Adegoke; Scott Franzblau; Bolanle A Adeniyi; Gail B Mahady
In vitro susceptibility of Mycobacterium tuberculosis to extracts of Eucalyptus camaldulensis and Eucalyptus torelliana and isolated compounds.
Pharmaceutical biology 2012;50(1):92-8.
2011: Yafei Jin; Paul D Kirchhoff; Scott Franzblau; George A Garcia; Sumandeep K Gill; Baojie Wan; H D Hollis Showalter
Synthesis and structure-activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin.
Bioorganic & medicinal chemistry letters 2011;21(20):6094-9.
2011: Andrew M Thompson; Baojie Wan; Yuehong Wang; Adrian Blaser; Scott Franzblau; Iveta Kmentova; Zhenkun Ma; Brian Palmer; Hamish S Sutherland; William A Denny
Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine (PA-824).
Journal of medicinal chemistry 2011;54(19):6563-85.
2011: Fernando R Pavan; Gustavo V Poelhsitz; Leticia S Sato; Sergio R A Leite; Virtudes Moreno; Marilia I F Barbosa; Alzir A Batista; Javier Ellena; Scott Franzblau; Dinorah Gambino; Clarice Queico Fujimura Leite
Ruthenium(II) phosphine/diimine/picolinate complexes: inorganic compounds as agents against tuberculosis.
European journal of medicinal chemistry 2011;46(10):5099-107.
2011: Xiaoyun Lu; Baojie Wan; Scott Franzblau; Qidong You
Design, synthesis and anti-tubercular evaluation of new 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl)thiophene-3-carboxylic acid derivatives. Part 1.
European journal of medicinal chemistry 2011;46(9):3551-63.
2011: Hiten J Gutka; Kamolchanok Rukseree; Paul R Wheeler; Scott Franzblau; Farahnaz Movahedzadeh
glpX gene of Mycobacterium tuberculosis: heterologous expression, purification, and enzymatic characterization of the encoded fructose 1,6-bisphosphatase II.
Applied biochemistry and biotechnology 2011;164(8):1376-89.
2011: Allan Patrick G Macabeo; Warren S Vidar; Xinyu Chen; Michael Decker; Jörg Heilmann; Baojie Wan; Scott Franzblau; Elano V Galvez; Ma Alicia M Aguinaldo; Geoffrey A Cordell
Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.
European journal of medicinal chemistry 2011;46(7):3118-23.
2011: Melfei E Bungihan; Thomas Edison E Dela Cruz; Scott Franzblau; Mariko Kitajima; Noriyuki Kogure; Hiromitsu Takayama; Mario A Tan; Maribel G Nonato
Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius.
Journal of natural medicines 2011;65(3-4):606-9.
2011: Nora C Vazquez-Laslop; Debbie C Mulhearn; Haripriya Ramu; Scott Franzblau; Dorota Klepacki; Olga Krasnykh; Alexander S Mankin
Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10496-501.
2011: Jing-Ping Lu; Xiu-Hua Yuan; Hai Yuan; Wen-Long Wang; Baojie Wan; Scott Franzblau; Qi-Zhuang Ye
Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives.
ChemMedChem 2011;6(6):1041-8.
2011: Hiten J Gutka; Scott Franzblau; Farahnaz Movahedzadeh; Cele Abad-Zapatero
Crystallization and preliminary X-ray characterization of the glpX-encoded class II fructose-1,6-bisphosphatase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 6):710-3.
2011: Abhijit Datta Khoje; Colin Charnock; Baojie Wan; Scott Franzblau; Lise-Lotte Gundersen
Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines: Imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles.
Bioorganic & medicinal chemistry 2011;19(11):3483-91.
2011: Kamaljit Singh; Kawaljit Singh; Baojie Wan; Scott Franzblau; Kelly Chibale; Jan Balzarini
Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity.
European journal of medicinal chemistry 2011;46(6):2290-4.
2011: Ngan B Truong; Cuong V Pham; Huong T M Doan; Hung V Nguyen; Cuong M Nguyen; Hiep T Nguyen; Hong-jie Zhang; Harry H S Fong; Scott Franzblau; D Doel Soejarto; Minh V Chau
Antituberculosis cycloartane triterpenoids from Radermachera boniana.
Journal of natural products 2011;74(5):1318-22.
2011: Renate H Hans; Ian J F Wiid; Paul D van Helden; Baojie Wan; Scott Franzblau; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.
Bioorganic & medicinal chemistry letters 2011;21(7):2055-8.
2011: C T Higuchi; Scott Franzblau; S R A Leite; F R Pavan; L V S Sacramento; Miriam Sannomiya; Daisy N Sato; Wagner Vilegas; Clarice Queico Fujimura Leite
Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity.
Evidence-based complementary and alternative medicine : eCAM 2011;2011():128349.
2010: Shunyan Mo; Aleksej Krunic; Bernard D Santarsiero; Scott Franzblau; Jimmy Orjala
Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.
Phytochemistry 2010;71(17-18):2116-23.
2010: N Raman; R Jeyamurugan; R Senthilkumar; B Rajkapoor; Scott Franzblau
In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model.
European journal of medicinal chemistry 2010;45(11):5438-51.
2010: Abhijit Datta Khoje; Aisvareya Kulendrn; Colin Charnock; Baojie Wan; Scott Franzblau; Lise-Lotte Gundersen
Synthesis of non-purine analogs of 6-aryl-9-benzylpurines, and their antimycobacterial activities. Compounds modified in the imidazole ring.
Bioorganic & medicinal chemistry 2010;18(20):7274-82.
2010: Marco Pieroni; Annamaria Lilienkampf; Yuehong Wang; Baojie Wan; SANG HYUN CHO; Scott Franzblau; Alan P Kozikowski
NOC chemistry for tuberculosis-further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives.
ChemMedChem 2010;5(10):1667-72.
2010: Oliver B Villaflores; Allan Patrick G Macabeo; Dietmar Gehle; Karsten Krohn; Scott Franzblau; Alicia M Aguinaldo
Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.
Pharmacognosy magazine 2010;6(24):339-44.
2010: E Paige Stout; Jacques Prudhomme; Karine Le Roch; Craig R Fairchild; Scott Franzblau; William Aalbersberg; Mark E Hay; Julia Kubanek
Unusual antimalarial meroditerpenes from tropical red macroalgae.
Bioorganic & medicinal chemistry letters 2010;20(19):5662-5.
2010: Megan Sturdy; Aleksej Krunic; SANG HYUN CHO; Scott Franzblau; Jimmy Orjala
Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.
Journal of natural products 2010;73(8):1441-3.
2010: Fernando R Pavan; Pedro I da S Maia; Sergio R A Leite; Victor M Deflon; Alzir A Batista; Daisy N Sato; Scott Franzblau; Clarice Queico Fujimura Leite
Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.
European journal of medicinal chemistry 2010;45(5):1898-905.
2010: Garrett C Moraski; Mayland Chang; Adriel Villegas-Estrada; Scott Franzblau; Ute Möllmann; Marvin J Miller
Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.
European journal of medicinal chemistry 2010;45(5):1703-16.
2010: Andréa Y Gordien; Alexander I Gray; Kevin Ingleby; Scott Franzblau; Véronique Seidel
Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis.
Phytotherapy research : PTR 2010;24(5):692-8.
2010: Jochen M Scher; Andreas Schinkovitz; Josef Zapp; Yuehong Wang; Scott Franzblau; Hans Becker; David C Lankin; Guido F Pauli
Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia.
Journal of natural products 2010;73(4):656-63.
2010: Taichi Inui; Yuehong Wang; Dejan Nikolic; David C Smith; Scott Franzblau; Guido F Pauli
Sesquiterpenes from Oplopanax horridus.
Journal of natural products 2010;73(4):563-7.
2010: José C Aponte; Abraham J Vaisberg; Denis Castillo; German Gonzalez; Yannick Estevez; Jorge Arevalo; Miguel Quiliano; Mirko Zimic; Manuela Verástegui; Edith Málaga; Robert H Gilman; Juan M Bustamante; Rick L Tarleton; Yuehong Wang; Scott Franzblau; Guido F Pauli; Michel Sauvain; Gerald B Hammond
Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.
Bioorganic & medicinal chemistry 2010;18(8):2880-6.
2010: Maohai Fang; R Daniel Toogood; Andrea Macova; Karen Ho; Scott Franzblau; Michael R McNeil; David A R Sanders; David R J Palmer
Succinylphosphonate esters are competitive inhibitors of MenD that show active-site discrimination between homologous alpha-ketoglutarate-decarboxylating enzymes.
Biochemistry 2010;49(12):2672-9.
2010: MinKyun Na; Yuanqing Ding; Bin Wang; Babu L Tekwani; Ray F Schinazi; Scott Franzblau; Michelle Kelly; Robert Stone; Xing-Cong Li; Daneel Ferreira; Mark T Hamann
Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.
Journal of natural products 2010;73(3):383-7.
2010: Bo Zhou; Yantao He; Xian Zhang; Jie Xu; Yong Luo; Yuehong Wang; Scott Franzblau; Zhenyun Yang; Rebecca J Chan; Yan Liu; Jianyu Zheng; Zhong-Yin Zhang
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4573-8.
2010: An-Shen Lin; E Paige Stout; Jacques Prudhomme; Karine Le Roch; Craig R Fairchild; Scott Franzblau; William Aalbersberg; Mark E Hay; Julia Kubanek
Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.
Journal of natural products 2010;73(2):275-8.
2010: Qi Hong; David E Minter; Scott Franzblau; Mohammad Arfan; Hazrat Amin; Manfred G Reinecke
Anti-tuberculosis compounds from Mallotus philippinensis.
Natural product communications 2010;5(2):211-7.
2010: Renate H Hans; Eric M Guantai; Carmen Lategan; Peter J Smith; Baojie Wan; Scott Franzblau; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.
Bioorganic & medicinal chemistry letters 2010;20(3):942-4.
2010: Jialin Mao; Hai Yuan; Yuehong Wang; Baojie Wan; Dennis Pak; Rong He; Scott Franzblau
Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs.
Bioorganic & medicinal chemistry letters 2010;20(3):1263-8.
2010: Fernando R Pavan; Gustavo Von Poelhsitz; Fábio B do Nascimento; Sergio R A Leite; Alzir A Batista; Victor M Deflon; Daisy N Sato; Scott Franzblau; Clarice Queico Fujimura Leite
Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents.
European journal of medicinal chemistry 2010;45(2):598-601.
2010: Annamaria Lilienkampf; Marco Pieroni; Baojie Wan; Yuehong Wang; Scott Franzblau; Alan P Kozikowski
Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development.
Journal of medicinal chemistry 2010;53(2):678-88.
2010: Songpo Guo; Yang Song; Qingqing Huang; Hai Yuan; Baojie Wan; Yuehong Wang; Rong He; Maria G Beconi; Scott Franzblau; Alan P Kozikowski
Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents.
Journal of medicinal chemistry 2010;53(2):649-59.
2010: Hamish S Sutherland; Adrian Blaser; Iveta Kmentova; Scott Franzblau; Baojie Wan; Yuehong Wang; Zhenkun Ma; Brian Palmer; William A Denny; Andrew M Thompson
Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains.
Journal of medicinal chemistry 2010;53(2):855-66.
2010: Andrej Maroz; Sujata S Shinde; Scott Franzblau; Zhenkun Ma; William A Denny; Brian Palmer; Robert F Anderson
Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent.
Organic & biomolecular chemistry 2010;8(2):413-8.
2010: Brian Palmer; Andrew M Thompson; Hamish S Sutherland; Adrian Blaser; Iveta Kmentova; Scott Franzblau; Baojie Wan; Yuehong Wang; Zhenkun Ma; William A Denny
Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Journal of medicinal chemistry 2010;53(1):282-94.
2009: Andréa Y Gordien; Alexander I Gray; Scott Franzblau; Véronique Seidel
Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae).
Journal of ethnopharmacology 2009;126(3):500-5.
2009: Jialin Mao; Hai Yuan; Yuehong Wang; Baojie Wan; Marco Pieroni; Qingqing Huang; Richard B Van Breemen; Alan P Kozikowski; Scott Franzblau
From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.
Journal of medicinal chemistry 2009;52(22):6966-78.
2009: Qingqing Huang; Jialin Mao; Baojie Wan; Yuehong Wang; Reto Brun; Scott Franzblau; Alan P Kozikowski
Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.
Journal of medicinal chemistry 2009;52(21):6757-67.
2009: Shunyan Mo; Aleksej Krunic; Scott D Pegan; Scott Franzblau; Jimmy Orjala
An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp.
Journal of natural products 2009;72(11):2043-5.
2009: Marco Pieroni; Annamaria Lilienkampf; Baojie Wan; Yuehong Wang; Scott Franzblau; Alan P Kozikowski
Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes.
Journal of medicinal chemistry 2009;52(20):6287-96.
2009: Songpo Guo; Suresh K Tipparaju; Scott D Pegan; Baojie Wan; Shunyan Mo; Jimmy Orjala; Andrew D Mesecar; Scott Franzblau; Alan P Kozikowski
Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.
Bioorganic & medicinal chemistry 2009;17(20):7126-30.
2009: Yujie Zhao; Adelbert Bacher; Boris Illarionov; Markus Fischer; Gunda I Georg; Qi-Zhuang Ye; Phillip E Fanwick; Scott Franzblau; Baojie Wan; Mark Cushman
Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis.
The Journal of organic chemistry 2009;74(15):5297-303.
2009: Enxian Lu; Scott Franzblau; Hayat Onyuksel; Carmen Popescu
Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion.
Journal of microencapsulation 2009;26(4):346-54.
2009: Annamaria Lilienkampf; Jialin Mao; Baojie Wan; Yuehong Wang; Scott Franzblau; Alan P Kozikowski
Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis.
Journal of medicinal chemistry 2009;52(7):2109-18.
2009: Amy L Lane; E Paige Stout; An-Shen Lin; Jacques Prudhomme; Karine G Le Roch; Craig R Fairchild; Scott Franzblau; Mark E Hay; William Aalbersberg; Julia Kubanek
Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.
The Journal of organic chemistry 2009;74(7):2736-42.
2009: Scott D Pegan; Kamolchanok Rukseree; Scott Franzblau; Andrew D Mesecar
Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
Journal of molecular biology 2009;386(4):1038-53.
2009: Andrew M Thompson; Adrian Blaser; Robert F Anderson; Sujata S Shinde; Scott Franzblau; Zhenkun Ma; William A Denny; Brian Palmer
Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Journal of medicinal chemistry 2009;52(3):637-45.
2009: Marvin J Miller; Helen Zhu; Yanping Xu; Chunrui Wu; Andrew J Walz; Anne Vergne; John M Roosenberg; Garrett Moraski; Albert A Minnick; Julia McKee-Dolence; Jingdan Hu; Kelley Fennell; E Kurt Dolence; Li Dong; Scott Franzblau; Francois Malouin; Ute Möllmann
Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2009;22(1):61-75.
2009: Ricardo Figueiredo; Cristina Moiteiro; M Augusta Medeiros; P Almeida da Silva; D Ramos; F Spies; M O Ribeiro; M Cristina S Lourenço; I N Júnior; M Manuela Gaspar; M Eugénia M Cruz; Maria João Marcelo Curto; Scott Franzblau; H Orozco; D Aguilar; R Hernandez-Pando; M Céu Costa
Synthesis and evaluation of rifabutin analogs against Mycobacterium avium and H(37)Rv, MDR and NRP Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry 2009;17(2):503-11.
2008: Anastasia Karioti; Helen Skaltsa; Xujie Zhang; Peter J Tonge; Remo Perozzo; Marcel Kaiser; Scott Franzblau; Deniz Tasdemir
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2008;15(12):1125-9.
2008: Julian G Hurdle; Robin B Lee; Nageshwar R Budha; Elizabeth I Carson; Jianjun Qi; Michael S Scherman; SANG HYUN CHO; Michael R McNeil; Anne J Lenaerts; Scott Franzblau; Bernd Meibohm; Richard E Lee
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.
The Journal of antimicrobial chemotherapy 2008;62(5):1037-45.
2008: Xiaomei Wei; Abimael D Rodriguez; Yuehong Wang; Scott Franzblau
Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2008;18(20):5448-50.
2008: Birgit U Jaki; Scott Franzblau; Lucas R Chadwick; David C Lankin; Fangqiu Zhang; Yuehong Wang; Guido F Pauli
Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.
Journal of natural products 2008;71(10):1742-8.
2008: Jialin Mao; HyungJin Eoh; Rong He; Yuehong Wang; Baojie Wan; Scott Franzblau; Dean Crick; Alan P Kozikowski
Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.
Bioorganic & medicinal chemistry letters 2008;18(19):5320-3.
2008: Hai Yuan; Rong He; Baojie Wan; Yuehong Wang; Guido F Pauli; Scott Franzblau; Alan P Kozikowski
Modification of the side chain of micromolide, an anti-tuberculosis natural product.
Bioorganic & medicinal chemistry letters 2008;18(19):5311-5.
2008: Lan H Ly; Rola Barhoumi; SANG HYUN CHO; Scott Franzblau; David N McMurray
Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivo.
The Journal of infectious diseases 2008;198(5):768-71.
2008: Esther Vicente; Raquel Villar; Asunción Burguete; Beatriz Solano; Silvia Pérez-Silanes; Ignacio Aldana; Joseph A Maddry; Anne J Lenaerts; Scott Franzblau; SANG HYUN CHO; Antonio Monge; Robert C Goldman
Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.
Antimicrobial agents and chemotherapy 2008;52(9):3321-6.
2008: Raquel Villar; Esther Vicente; Beatriz Solano; Silvia Pérez-Silanes; Ignacio Aldana; Joseph A Maddry; Anne J Lenaerts; Scott Franzblau; SANG HYUN CHO; Antonio Monge; Robert C Goldman
In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.
The Journal of antimicrobial chemotherapy 2008;62(3):547-54.
2008: Zhaohai J Zhu; Olga Krasnykh; Dahua Pan; Valentina Petukhova; Gengli Yu; Yinghui Liu; Huiwen Liu; Sa Weon Hong; Yuehong Wang; Baojie Wan; Wenzhong Liang; Scott Franzblau
Structure-activity relationships of macrolides against Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2008;88 Suppl 1():S49-63.
2008: Shixin Deng; Yuehong Wang; Taichi Inui; Shaonong Chen; Norman R Farnsworth; SANG HYUN CHO; Scott Franzblau; Guido F Pauli
Anti-TB polyynes from the roots of Angelica sinensis.
Phytotherapy research : PTR 2008;22(7):878-82.
2008: Ya Zhou; Aaron B Beeler; SANG HYUN CHO; Yuehong Wang; Scott Franzblau; John K Snyder
Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds.
Journal of combinatorial chemistry 2008;10(4):534-40.
2008: Subash Velaparthi; Michael Brunsteiner; Reaz Uddin; Baojie Wan; Scott Franzblau; Pavel A Petukhov
5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.
Journal of medicinal chemistry 2008;51(7):1999-2002.
2008: Mario A Tan; Hiromitsu Takayama; Norio Aimi; Mariko Kitajima; Scott Franzblau; Maribel G Nonato
Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis.
Journal of natural medicines 2008;62(2):232-5.
2008: Khalid A El Sayed; Ashraf A Khalil; Muhammad Yousaf; Guillermo Labadie; Mahesh Gundluru; Scott Franzblau; Alejandro M S Mayer; Mitchell A Avery; Mark T Hamann
Semisynthetic studies on the manzamine alkaloids.
Journal of natural products 2008;71(3):300-8.
2008: Deniz Tasdemir; Reto Brun; Scott Franzblau; Yükselen Sezgin; Ihsan Calis
Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2008;15(3):209-15.
2007: Jialin Mao; Yuehong Wang; Baojie Wan; Alan P Kozikowski; Scott Franzblau
Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents.
ChemMedChem 2007;2(11):1624-30.
2007: Amy L Lane; Elizabeth P Stout; Mark E Hay; Anne C Prusak; Kenneth I Hardcastle; Craig R Fairchild; Scott Franzblau; Karine G Le Roch; Jacques Prudhomme; William Aalbersberg; Julia Kubanek
Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.
The Journal of organic chemistry 2007;72(19):7343-51.
2007: Jialin Mao; Baojie Wan; Yuehong Wang; Scott Franzblau; Alan P Kozikowski
HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery.
ChemMedChem 2007;2(6):811-3.
2007: Alicia M Aguinaldo; Victoria M Dalangin-Mallari; Allan Patrick G Macabeo; Lindsay T Byrne; Fumiko Abe; Tatsuo Yamauchi; Scott Franzblau
Quinoline alkaloids from Lunasia amara inhibit Mycobacterium tuberculosis H37Rv in vitro.
International journal of antimicrobial agents 2007;29(6):744-6.
2007: Taichi Inui; Yuehong Wang; Shixin Deng; David C Smith; Scott Franzblau; Guido F Pauli
Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical.
Journal of chromatography. A 2007;1151(1-2):211-5.
2007: Ryan J Case; Yuehong Wang; Scott Franzblau; D Doel Soejarto; Lohi Matainaho; Pius Piskaut; Guido F Pauli
Advanced applications of counter-current chromatography in the isolation of anti-tuberculosis constituents from Dracaena angustifolia.
Journal of chromatography. A 2007;1151(1-2):169-74.
2007: SANG HYUN CHO; Saradee Warit; Baojie Wan; Chang Hwa Hwang; Guido F Pauli; Scott Franzblau
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2007;51(4):1380-5.
2007: Aaron B Bate; Jay H Kalin; Eric M Fooksman; Erica L Amorose; Cristofer M Price; Heather M Williams; Michael J Rodig; Miguel O Mitchell; SANG HYUN CHO; Yuehong Wang; Scott Franzblau
Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.
Bioorganic & medicinal chemistry letters 2007;17(5):1346-8.
2006: Marvin J Miller; Gaiying Zhao; Sergei B Vakulenko; Scott Franzblau; Ute Möllmann
New C-3' hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents.
Organic & biomolecular chemistry 2006;4(22):4178-85.
2006: Deniz Tasdemir; Reto Brun; Vanessa Yardley; Scott Franzblau; Peter Rüedi
Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies.
Chemistry & biodiversity 2006;3(11):1230-7.
2006: N B Bapela; Namrita Lall; PB Fourie; Scott Franzblau; C E J Van Rensburg
Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2006;13(9-10):630-5.
2006: Gaiying Zhao; Marvin J Miller; Scott Franzblau; Baojie Wan; Ute Möllmann
Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents.
Bioorganic & medicinal chemistry letters 2006;16(21):5534-7.
2006: SANG HYUN CHO; David Goodlett; Scott Franzblau
ICAT-based comparative proteomic analysis of non-replicating persistent Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2006;86(6):445-60.
2006: Seungok Lee; D H Kong; S H Yun; K R Lee; K P Lee; Scott Franzblau; E Y Lee; C L Chang
Evaluation of a modified antimycobacterial susceptibility test using Middlebrook 7H10 agar containing 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride.
Journal of microbiological methods 2006;66(3):548-51.
2006: Taylor A Choi; Regina Czerwonka; Wolfgang Fröhner; Micha P Krahl; Kethiri R Reddy; Scott Franzblau; Hans-Joachim Knölker
Synthesis and activity of carbazole derivatives against Mycobacterium tuberculosis.
ChemMedChem 2006;1(8):812-5.
2006: Karumanchi V Rao; Marwa Donia; Jiangnan Peng; Esther Garcia-Palomero; Diana Alonso; Ana Martinez; Miguel Medina; Scott Franzblau; Babu L Tekwani; Shabana I Khan; Subagus Wahyuono; Kristine L Willett; Mark T Hamann
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.
Journal of natural products 2006;69(7):1034-40.
2006: Ryan J Case; Scott Franzblau; Yuehong Wang; SANG HYUN CHO; D Doel Soejarto; Guido F Pauli
Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus.
Journal of ethnopharmacology 2006;106(1):82-9.
2006: Sarva Jayaprakash; Yasuyoshi Iso; Baojie Wan; Scott Franzblau; Alan P Kozikowski
Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents.
ChemMedChem 2006;1(6):593-7.
2006: Néstor M Carballeira; David Sanabria; Clarisa Cruz; Keykavous Parang; Baojie Wan; Scott Franzblau
2,6-hexadecadiynoic acid and 2,6-nonadecadiynoic acid: novel synthesized acetylenic fatty acids as potent antifungal agents.
Lipids 2006;41(5):507-11.
2006: Birgit U Jaki; Scott Franzblau; SANG HYUN CHO; Guido F Pauli
Development of an extraction method for mycobacterial metabolome analysis.
Journal of pharmaceutical and biomedical analysis 2006;41(1):196-200.
2006: Jian-Qiao Gu; Yuehong Wang; Scott Franzblau; Gloria Montenegro; Barbara N Timmermann
Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS.
Phytochemical analysis : PCA 2006;17(2):102-6.
2006: D Doel Soejarto; Hong-Jie Zhang; Harry H S Fong; Ghee Teng Tan; Cui-Ying Ma; Charlotte Gyllenhaal; Mary C Riley; Marian R Kadushin; Scott Franzblau; Truong Quang Bich; Nguyen Manh Cuong; Nguyen Tien Hiep; Phan Ke Loc; Le Thi Xuan; Nong Van Hai; Nguyen Van Hung; Nguyen Quyet Chien; Le Tran Binh; Bui Minh Vu; Ho Minh Ly; Bounhoong Southavong; Kongmany Sydara; Somsanith Bouamanivong; John M Pezzuto; William C Rose; Gregg R Dietzman; Byron E Miller; Tran Van Thuy
"Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact.
Journal of natural products 2006;69(3):473-81.
2005: Guido F Pauli; Ryan J Case; Taichi Inui; Yuehong Wang; SANG HYUN CHO; Nikolaus H Fischer; Scott Franzblau
New perspectives on natural products in TB drug research.
Life sciences 2005;78(5):485-94.
2005: Maria-Teresa Gutierrez-Lugo; Yuehong Wang; Scott Franzblau; Enrique Suarez; Barbara N Timmermann
Antitubercular sterols from Thalia multiflora Horkel ex Koernicke.
Phytotherapy research : PTR 2005;19(10):876-80.
2005: Isabel Rivero-Cruz; Laura Acevedo; José A Guerrero; Sergio Martínez; Robert Bye; Rogelio Pereda-Miranda; Scott Franzblau; Barbara N Timmermann; Rachel Mata
Antimycobacterial agents from selected Mexican medicinal plants.
The Journal of pharmacy and pharmacology 2005;57(9):1117-26.
2005: D Doel Soejarto; Harry H S Fong; Ghee Teng Tan; Hong-Jie Zhang; Cui-Ying Ma; Scott Franzblau; Charlotte Gyllenhaal; M C Riley; Marian R Kadushin; John M Pezzuto; L T Xuan; Nguyen Tien Hiep; Nguyen Van Hung; B M Vu; P K Loc; L X Dac; L T Binh; N Q Chien; N V Hai; Truong Quang Bich; Nguyen Manh Cuong; Bounhoong Southavong; Kongmany Sydara; Somsanith Bouamanivong; Ho Minh Ly; Tran Van Thuy; William C Rose; G R Dietzman
Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing.
Journal of ethnopharmacology 2005;100(1-2):15-22.
2005: Toshihiro Akihisa; Scott Franzblau; Harukuni Tokuda; Masaaki Tagata; Motohiko Ukiya; Tsunetomo Matsuzawa; Koichi Metori; Yumiko Kimura; Takashi Suzuki; Ken Yasukawa
Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus.
Biological & pharmaceutical bulletin 2005;28(6):1117-9.
2005: Allan Patrick G Macabeo; Karsten Krohn; Dietmar Gehle; Roger W Read; Joseph J Brophy; Geoffrey A Cordell; Scott Franzblau; Alicia M Aguinaldo
Indole alkaloids from the leaves of Philippine Alstonia scholaris.
Phytochemistry 2005;66(10):1158-62.
2005: Kanakeshwari Falzari; Zhaohai Zhu; Dahua Pan; Huiwen Liu; Poonpilas Hongmanee; Scott Franzblau
In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2005;49(4):1447-54.
2005: Scott Franzblau
A potentially new treatment for tuberculosis; will a diarylquinoline work for leprosy?
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2005;73(1):32.
2005: Cuiying Ma; Ryan J Case; Yuehong Wang; Hong-Jie Zhang; Ghee Teng Tan; Nguyen Van Hung; Nguyen Manh Cuong; Scott Franzblau; D Doel Soejarto; Harry H S Fong; Guido F Pauli
Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.
Planta medica 2005;71(3):261-7.
2005: Toshihiro Akihisa; Scott Franzblau; Motohiko Ukiya; Hiroki Okuda; Fangqiu Zhang; Ken Yasukawa; Takashi Suzuki; Yumiko Kimura
Antitubercular activity of triterpenoids from Asteraceae flowers.
Biological & pharmaceutical bulletin 2005;28(1):158-60.
2004: Rachel Mata; Iliana Morales; Olga Pérez; Isabel Rivero-Cruz; Laura Acevedo; Isolda Enriquez-Mendoza; Robert Bye; Scott Franzblau; Barbara Timmermann
Antimycobacterial compounds from Piper sanctum.
Journal of natural products 2004;67(12):1961-8.
2004: Jian-Qiao Gua; Yuehong Wang; Scott Franzblau; Gloria Montenegro; Barbara N Timmermann
Constituents of Quinchamalium majus with potential antitubercular activity.
Zeitschrift für Naturforschung. C, Journal of biosciences 2004;59(11-12):797-802.
2004: Rajendra P Tangallapally; Raghunandan Yendapally; Richard E Lee; Kirk Edward Hevener; Victoria Jones; Anne J Lenaerts; Michael R McNeil; Yuehong Wang; Scott Franzblau; Richard E Lee
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents.
Journal of medicinal chemistry 2004;47(21):5276-83.
2004: Jian-Qiao Gu; Yuehong Wang; Scott Franzblau; Gloria Montenegro; Barbara N Timmermann
Constituents of Senecio chionophilus with potential antitubercular activity.
Journal of natural products 2004;67(9):1483-7.
2004: Néstor M Carballeira; Heidyleen Cruz; Cecil D Kwong; Baojie Wan; Scott Franzblau
2-methoxylated fatty acids in marine sponges: defense mechanism against mycobacteria?
Lipids 2004;39(7):675-80.
2004: Birgit U Jaki; Scott Franzblau; Guido F Pauli
An NMR method towards the routine chiral determination of natural products.
Phytochemical analysis : PCA 2004;15(4):213-9.
2004: Jian-Qiao Gu; Yuehong Wang; Scott Franzblau; Gloria Montenegro; Danzhou Yang; Barbara N Timmermann
Antitubercular constituents of Valeriana laxiflora.
Planta medica 2004;70(6):509-14.
2004: Girma M Woldemichael; Maria-Teresa Gutierrez-Lugo; Scott Franzblau; Yuehong Wang; Enrique Suarez; Barbara N Timmermann
Mycobacterium tuberculosis growth inhibition by constituents of Sapium haematospermum.
Journal of natural products 2004;67(4):598-603.
2003: Chartchai Changsen; Scott Franzblau; Prasit Palittapongarnpim
Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter.
Antimicrobial agents and chemotherapy 2003;47(12):3682-7.
2003: Jiangnan Peng; Jin-Feng Hu; Abul B Kazi; Ze Li; Mitchell Avery; Olivier Peraud; Russell T Hill; Scott Franzblau; Fangqiu Zhang; Ray F Schinazi; Susan S Wirtz; Phillip Tharnish; Michelle Kelly; Subagus Wahyuono; Mark T Hamann
Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.
Journal of the American Chemical Society 2003;125(44):13382-6.
2003: Girma M Woldemichael; Scott Franzblau; Fangqiu Zhang; Yuehong Wang; Barbara N Timmermann
Inhibitory effect of sterols from Ruprechtia triflora and diterpenes from Calceolaria pinnifolia on the growth of Mycobacterium tuberculosis.
Planta medica 2003;69(7):628-31.
2003: J I Murillo; R Encarnación-Dimayuga; Joan Malmstrøm; Carsten Christophersen; Scott Franzblau
Antimycobacterial flavones from Haplopappus sonorensis.
Fitoterapia 2003;74(3):226-30.
2003: J Luna-Herrera; G Martínez-Cabrera; R Parra-Maldonado; J Antonio Enciso-Moreno; J Torres-López; F Quesada-Pascual; R Delgadillo-Polanco; Scott Franzblau
Use of receiver operating characteristic curves to assess the performance of a microdilution assay for determination of drug susceptibility of clinical isolates of Mycobacterium tuberculosis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2003;22(1):21-7.
2002: Suporn Foongladda; D Roengsanthia; W Arjrattanakool; C Chuchottaworn; Angkana Chaiprasert; Scott Franzblau
Rapid and simple MTT method for rifampicin and isoniazid susceptibility testing of Mycobacterium tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2002;6(12):1118-22.
2002: Jonel P Saludes; Mary J Garson; Scott Franzblau; Alicia M Aguinaldo
Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).
Phytotherapy research : PTR 2002;16(7):683-5.
2002: Uday Sandbhor; Subhash Padhye; David Billington; Daniel Rathbone; Scott Franzblau; Christopher E Anson; Annie Powell
Metal complexes of carboxamidrazone analogs as antitubercular agents. 1. Synthesis, X-ray crystal-structures, spectroscopic properties and antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv.
Journal of inorganic biochemistry 2002;90(3-4):127-36.
2001: M D Antoun; Z Ramos; J Vazques; I Oquendo; G R Proctor; L Gerena; Scott Franzblau
Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.
Phytotherapy research : PTR 2001;15(7):638-42.
2001: Charles L Cantrell; Scott Franzblau; Nikolaus H Fischer
Antimycobacterial plant terpenoids.
Planta medica 2001;67(8):685-94.
2001: Gerald A Wächter; Scott Franzblau; Gloria Montenegro; JJ Hoffmann; William M Maiese; Barbara N Timmermann
Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens.
Journal of natural products 2001;64(11):1463-4.
2001: G H Constantine; Joseph J Karchesy; Scott Franzblau; L E LaFleur
(+)-Totarol from Chamaecyparis nootkatensis and activity against Mycobacterium tuberculosis.
Fitoterapia 2001;72(5):572-4.
2001: Chad E Stephens; Farial A Tanious; S Kim; David W. Wilson; Wiley A Schell; J R Perfect; Scott Franzblau; David W Boykin
Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.
Journal of medicinal chemistry 2001;44(11):1741-8.
2001: M H Gezginci; AR Martin; Scott Franzblau
Antimycobacterial activity of substituted isosteres of pyridine- and pyrazinecarboxylic acids. 2.
Journal of medicinal chemistry 2001;44(10):1560-3.
2001: Yufang Ma; Richard J Stern; Michael S Scherman; Varalakshmi D Vissa; W Yan; Victoria Jones; F Zhang; Scott Franzblau; W H Lewis; Michael R McNeil
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose.
Antimicrobial agents and chemotherapy 2001;45(5):1407-16.
2001: Gerald A Wächter; Susanne Valcic; Scott Franzblau; Enrique Suarez; Barbara N Timmermann
Antitubercular activity of triterpenoids from Lippia turbinata.
Journal of natural products 2001;64(1):37-41.
2000: Scott Franzblau
A rapid, microplate-based assay for evaluating the activity of drugs against Mycobacterium leprae, employing the reduction of Alamar Blue.
Leprosy review 2000;71 Suppl():S74-5; discussion S76.
2000: C G Caldwell; Scott Franzblau; Enrique Suarez; Barbara N Timmermann
Oleanane triterpenes from Junellia tridens.
Journal of natural products 2000;63(12):1611-4.
2000: Gina C Mangalindan; M T Talaue; Lourdes J Cruz; Scott Franzblau; Linda B Adams; Adam Richardson; Chris M Ireland; Gisela P Concepcion
Agelasine F from a Philippine Agelas sp. sponge exhibits in vitro antituberculosis activity.
Planta medica 2000;66(4):364-5.
2000: Gabriele M König; Anthony D Wright; Scott Franzblau
Assessment of antimycobacterial activity of a series of mainly marine derived natural products.
Planta medica 2000;66(4):337-42.
2000: Laura Acevedo; E Martínez; P Castañeda; Scott Franzblau; Barbara N Timmermann; Edelmira Linares; Robert Bye; Rachel Mata
New phenylethanoids from Buddleja cordata subsp. cordata.
Planta medica 2000;66(3):257-61.
1999: Charles L Cantrell; Mohamed S Rajab; Scott Franzblau; Frank R Fronczek; Nikolaus H Fischer
Antimycobacterial ergosterol-5,8-endoperoxide from Ajuga remota.
Planta medica 1999;65(8):732-4.
1999: Gerald A Wächter; Susanne Valcic; ML Flagg; Scott Franzblau; Gloria Montenegro; Enrique Suarez; Barbara N Timmermann
Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1999;6(5):341-5.
1999: JK Rugutt; CW Henry; Scott Franzblau; Isiah M Warner
NMR and molecular mechanics study of pyrethrins I and II.
Journal of agricultural and food chemistry 1999;47(8):3402-10.
1999: Linda B Adams; I Sinha; Scott Franzblau; James L Krahenbuhl; RT Mehta
Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine.
Antimicrobial agents and chemotherapy 1999;43(7):1638-43.
1999: Susanne Valcic; Gloria Montenegro; A M Mujica; G Avila; Scott Franzblau; Maya P Singh; William M Maiese; Barbara N Timmermann
Phytochemical, morphological, and biological investigations of propolis from Central Chile.
Zeitschrift für Naturforschung. C, Journal of biosciences 1999;54(5-6):406-16.
1999: Charles L Cantrell; L Abate; Frank R Fronczek; Scott Franzblau; L Quijano; Nikolaus H Fischer
Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.
Planta medica 1999;65(4):351-5.
1999: Charles L Cantrell; Mohamed S Rajab; Scott Franzblau; Nikolaus H Fischer
Antimycobacterial triterpenes from Melia volkensii.
Journal of natural products 1999;62(4):546-8.
1998: T Lu; Charles L Cantrell; S L Robbs; Scott Franzblau; Nikolaus H Fischer
Antimycobacterial matricaria esters and lactones from Astereae species.
Planta medica 1998;64(7):665-7.
1998: Charles L Cantrell; I S Nuñez; J Castañeda-Acosta; M Foroozesh; Frank R Fronczek; Nikolaus H Fischer; Scott Franzblau
Antimycobacterial activities of dehydrocostus lactone and its oxidation products.
Journal of natural products 1998;61(10):1181-6.
1998: Nikolaus H Fischer; T Lu; Charles L Cantrell; J Castañeda-Acosta; L Quijano; Scott Franzblau
Antimycobacterial evaluation of germacranolides.
Phytochemistry 1998;49(2):559-64.
1998: Gerald A Wächter; Scott Franzblau; Gloria Montenegro; Enrique Suarez; R H Fortunato; E Saavedra; Barbara N Timmermann
A new antitubercular mulinane diterpenoid from Azorella madreporica Clos.
Journal of natural products 1998;61(7):965-8.
1998: Gerald A Wächter; M C Davis; AR Martin; Scott Franzblau
Antimycobacterial activity of substituted isosteres of pyridine- and pyrazinecarboxylic acids.
Journal of medicinal chemistry 1998;41(13):2436-8.
1998: M C Davis; Scott Franzblau; AR Martin
Syntheses and evaluation of benzodiazaborine compounds against M. tuberculosis H37Rv in vitro.
Bioorganic & medicinal chemistry letters 1998;8(7):843-6.
1998: Charles L Cantrell; Nikolaus H Fischer; M S McGuire; L Urbatsch; Scott Franzblau
Antimycobacterial crude plant extracts from South, Central, and North America.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1998;5(2):137-45.
1998: L A Collins; M N Torrero; Scott Franzblau
Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 1998;42(2):344-7.
1998: Mohamed S Rajab; Charles L Cantrell; Scott Franzblau; Nikolaus H Fischer
Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study.
Planta medica 1998;64(1):2-4.
1998: Scott Franzblau; R S Witzig; J C McLaughlin; P Torres; G Madico; A Hernandez; M T Degnan; M B Cook; V K Quenzer; R M Ferguson; Robert H Gilman
Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay.
Journal of clinical microbiology 1998;36(2):362-6.
1997: L Collins; Scott Franzblau
Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium.
Antimicrobial agents and chemotherapy 1997;41(5):1004-9.
1996: Charles L Cantrell; T Lu; Frank R Fronczek; Nikolaus H Fischer; Linda B Adams; Scott Franzblau
Antimycobacterial cycloartanes from Borrichia frutescens.
Journal of natural products 1996;59(12):1131-6.
1995: Tranquilino T Fajardo; Laarni G Villahermosa; Eduardo C dela Cruz; Rodolfo M Abalos; Scott Franzblau; Gerald P Walsh
Minocycline in lepromatous leprosy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1995;63(1):8-17.
1995: T Lu; D Vargas; Scott Franzblau; Nikolaus H Fischer
Diterpenes from Solidago rugosa.
Phytochemistry 1995;38(2):451-6.
1994: Scott Franzblau; G P Chan; B G Garcia-Ignacio; V E Chavez; J B Livelo; C L Jimenez; M L Parrilla; R F Calvo; Diana L Williams; Thomas P Gillis
Clinical trial of fusidic acid for lepromatous leprosy.
Antimicrobial agents and chemotherapy 1994;38(7):1651-4.
1994: G P Chan; B Y Garcia-Ignacio; V E Chavez; J B Livelo; C L Jimenez; M L Parrilla; Scott Franzblau
Clinical trial of clarithromycin for lepromatous leprosy.
Antimicrobial agents and chemotherapy 1994;38(3):515-7.
1994: G P Chan; B Y Garcia-Ignacio; V E Chavez; J B Livelo; C L Jimenez; M L Parrilla; Scott Franzblau
Clinical trial of sparfloxacin for lepromatous leprosy.
Antimicrobial agents and chemotherapy 1994;38(1):61-5.
1993: R S Witzig; Scott Franzblau
Susceptibility of Mycobacterium kansasii to ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid.
Antimicrobial agents and chemotherapy 1993;37(9):1997-9.
1993: Scott Franzblau; M L Parrilla; G P Chan
Sparfloxacin is more bactericidal than ofloxacin against Mycobacterium leprae in mice.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1993;61(1):66-9.
1992: Scott Franzblau; A N Biswas; P Jenner; M J Colston
Double-blind evaluation of BACTEC and Buddemeyer-type radiorespirometric assays for in vitro screening of antileprosy agents.
Leprosy review 1992;63(2):125-33.
1992: Scott Franzblau; A N Biswas; EB Harris
Fusidic acid is highly active against extracellular and intracellular Mycobacterium leprae.
Antimicrobial agents and chemotherapy 1992;36(1):92-4.
1991: N Ramasesh; Linda B Adams; Scott Franzblau; James L Krahenbuhl
Effects of activated macrophages on Mycobacterium leprae.
Infection and immunity 1991;59(9):2864-9.
1991: Linda B Adams; Scott Franzblau; Z Vavrin; J B Hibbs; James L Krahenbuhl
L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1642-6.
1991: Scott Franzblau
In vitro activities of aminoglycosides, lincosamides, and rifamycins against Mycobacterium leprae.
Antimicrobial agents and chemotherapy 1991;35(6):1232-4.
1990: Scott Franzblau; K E White
Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae.
Antimicrobial agents and chemotherapy 1990;34(2):229-31.
1989: Scott Franzblau
Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system.
Antimicrobial agents and chemotherapy 1989;33(12):2115-7.
1989: Scott Franzblau; K E White; J F O'Sullivan
Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro.
Antimicrobial agents and chemotherapy 1989;33(11):2004-5.
1988: Scott Franzblau; R C Hastings
In vitro and in vivo activities of macrolides against Mycobacterium leprae.
Antimicrobial agents and chemotherapy 1988;32(12):1758-62.
1988: EB Harris; Scott Franzblau; R C Hastings
Inhibition of phenolic glycolipid-I synthesis in extracellular Mycobacterium leprae as an indicator of antimicrobial activity.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1988;56(4):588-91.
1988: Scott Franzblau; J F O'Sullivan
Structure-activity relationships of selected phenazines against Mycobacterium leprae in vitro.
Antimicrobial agents and chemotherapy 1988;32(10):1583-5.
1988: R C Hastings; Thomas P Gillis; James L Krahenbuhl; Scott Franzblau
Leprosy.
Clinical microbiology reviews 1988;1(3):330-48.
1988: Scott Franzblau; EB Harris
Biophysical optima for metabolism of Mycobacterium leprae.
Journal of clinical microbiology 1988;26(6):1124-9.
1988: R C Hastings; Scott Franzblau
Chemotherapy of leprosy.
Annual review of pharmacology and toxicology 1988;28():231-45.
1988: Scott Franzblau
Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium.
Journal of clinical microbiology 1988;26(1):18-21.
1987: Scott Franzblau; R C Hastings
Rapid in vitro metabolic screen for antileprosy compounds.
Antimicrobial agents and chemotherapy 1987;31(5):780-3.
1987: L David Sibley; Scott Franzblau; James L Krahenbuhl
Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages.
Infection and immunity 1987;55(3):680-5.
1986: Scott Franzblau; C Cross
Comparative in vitro antimicrobial activity of Chinese medicinal herbs.
Journal of ethnopharmacology 1986;15(3):279-88.
1986: Scott Franzblau; T Takeda; M Nakamura
Mycobacterial plasmids: screening and possible relationship to antibiotic resistance in Mycobacterium avium/Mycobacterium intracellulare.
Microbiology and immunology 1986;30(9):903-7.
1984: Scott Franzblau; B J Hinnebusch; L M Kelley; N A Sinclair
Effect of noncoliforms on coliform detection in potable groundwater: improved recovery with an anaerobic membrane filter technique.
Applied and environmental microbiology 1984;48(1):142-8.
1983: Scott Franzblau; N A Sinclair
Induction of pyruvate decarboxylase in Candida utilis.
Mycopathologia 1983;83(1):29-33.