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Isabel Cardoso

Research Profile

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Sandra Rocha; Isabel Cardoso; Hans Börner; Maria Carmo Pereira; Maria João Saraiva; Manuel Coelho
Design and biological activity of beta-sheet breaker peptide conjugates.
R Costa; A Gonçalves; Maria João Saraiva; Isabel Cardoso
Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.
Isabel Cardoso; M Brito; Maria João Saraiva
Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related.

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All Publications

2009: Sandra Rocha; Isabel Cardoso; Hans Börner; Maria Carmo Pereira; Maria João Saraiva; Manuel Coelho
Design and biological activity of beta-sheet breaker peptide conjugates.
Biochemical and biophysical research communications 2009;380(2):397-401.
2008: R Costa; A Gonçalves; Maria João Saraiva; Isabel Cardoso
Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.
FEBS letters 2008;582(6):936-42.
2008: Isabel Cardoso; M Brito; Maria João Saraiva
Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related.
Disease markers 2008;25(1):37-47.
2008: Rita Costa; Frederico Ferreira-da-Silva; Maria J Saraiva; Isabel Cardoso
Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.
PloS one 2008;3(8):e2899.
2007: Isabel Cardoso; Maria Rosário Almeida; Nelson Ferreira; Gemma Arsequell; Gregorio Valencia; Maria João Saraiva
Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design.
The Biochemical journal 2007;408(1):131-8.
2007: Sofia D Santos; Isabel Cardoso; João Magalhães; Maria João Saraiva
Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy.
The Journal of pathology 2007;213(2):200-9.
2007: João Carlos Sousa; Isabel Cardoso; Fernanda Marques; Maria João Saraiva; Joana Almeida Palha
Transthyretin and Alzheimer's disease: where in the brain?
Neurobiology of aging 2007;28(5):713-8.
2006: Filipe Almeida Monteiro; Isabel Cardoso; Mónica Mendes Sousa; Maria João Saraiva
In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE).
FEBS letters 2006;580(14):3451-6.
2006: F A Monteiro; Mónica Mendes Sousa; Isabel Cardoso; José Barbas do Amaral; António Guimarães; Maria João Saraiva
Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy.
Journal of neurochemistry 2006;97(1):151-61.
2006: Isabel Cardoso; Maria João Saraiva
Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):234-9.
2005: Maria Rosário Almeida; Luís Gales; Ana M Damas; Isabel Cardoso; Maria João Saraiva
Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses.
Current drug targets. CNS and neurological disorders 2005;4(5):587-96.
2004: Maria Rosário Almeida; Bárbara Macedo; Isabel Cardoso; Isabel Alves; Gregorio Valencia; Gemma Arsequell; Antoni Planas; Maria João Saraiva
Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative.
The Biochemical journal 2004;381(Pt 2):351-6.
2004: Maria João Saraiva; Mónica Mendes Sousa; Isabel Cardoso; Rui Fernandes
Familial amyloidotic polyneuropathy: protein aggregation in the peripheral nervous system.
Journal of molecular neuroscience : MN 2004;23(1-2):35-40.
2003: Isabel Cardoso; Giampaolo Merlini; Maria João Saraiva
4'-iodo-4'-deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(8):803-9.
2003: Luís Gales; Isabel Cardoso; Barbara Fayard; Alexandre Quintanilha; Maria João Saraiva; Ana M Damas
X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization.
The Journal of biological chemistry 2003;278(13):11654-60.
2002: Isabel Cardoso; Claire Goldsbury; Shirley A Müller; Vesna Olivieri; S Wirtz; Ana M Damas; Ueli Aebi; Maria João Saraiva
Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils.
Journal of molecular biology 2002;317(5):683-95.
2001: Mónica Mendes Sousa; Isabel Cardoso; Rui Fernandes; António Guimarães; Maria João Saraiva
Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates.
The American journal of pathology 2001;159(6):1993-2000.
2001: A Quintas; D C Vaz; Isabel Cardoso; Maria João Saraiva; Rui Brito
Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants.
The Journal of biological chemistry 2001;276(29):27207-13.
2000: Joana Almeida Palha; D Ballinari; N Amboldi; Isabel Cardoso; Rui Fernandes; V Bellotti; G Merlini; Maria João Saraiva
4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid.
The American journal of pathology 2000;156(6):1919-25.
2000: Isabel Cardoso; Pedro J B Pereira; Ana M Damas; Maria João Saraiva
Aprotinin binding to amyloid fibrils.
European journal of biochemistry / FEBS 2000;267(8):2307-11.