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Khawla Al-Kuraya

Research Profile

Chemicals & Drugs

Anatomy

Tumor Cell Line

Physiology

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Saudi Arabia

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Azhar R Hussain; Shahab Uddin; Maqbool Ahmed; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya
Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release.
Rong Bu; Zeenath Jehan; Shahab Uddin; Prashant Bavi; Jehad Abubaker; Dahish Ajarim; Fouad Al Dayel; Wael Al-Haqawi; Khawla S Al-Kuraya
Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma.
Shahab Uddin; Maqbool Ahmed; Fouad Al Dayel; Prashant Bavi; Azhar R Hussain; Khawar Siddiqui; Khawla S Al-Kuraya
Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma.

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All Publications

2013: Azhar R Hussain; Shahab Uddin; Maqbool Ahmed; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya
Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release.
PloS one 2013;8(3):e60540.
2012: Rong Bu; Zeenath Jehan; Shahab Uddin; Prashant Bavi; Jehad Abubaker; Dahish Ajarim; Fouad Al Dayel; Wael Al-Haqawi; Khawla S Al-Kuraya
Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma.
Leukemia & lymphoma 2012;53(10):1971-7.
2012: Shahab Uddin; Maqbool Ahmed; Fouad Al Dayel; Prashant Bavi; Azhar R Hussain; Khawar Siddiqui; Khawla S Al-Kuraya
Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma.
Haematologica 2012;97(7):1092-100.
2012: Azhar R Hussain; Omar S Khan; Leonidas C Platanias; Maqbool Ahmed; Saeeda O Ahmed; Sally Al Abdulmohsen; Khawla S Al-Kuraya; Shahab Uddin
Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.
PloS one 2012;7(6):e39945.
2012: Zeenath Jehan; Shahab Uddin; Khawla S Al-Kuraya
In-situ hybridization as a molecular tool in cancer diagnosis and treatment.
Current medicinal chemistry 2012;19(22):3730-8.
2012: Rong Bu; Azhar R Hussain; Shahab Uddin; Jehad Abubaker; Maqbool Ahmed; Fouad Al Dayel; Abdurahman Al-Nuaim; Saif Alsobhi; Tarek Amin; Prashant Bavi; Khawla S Al-Kuraya
c-Met inhibitor synergizes with tumor necrosis factor-related apoptosis-induced ligand to induce papillary thyroid carcinoma cell death.
Molecular medicine (Cambridge, Mass.) 2012;18():167-77.
2011: Shahab Uddin; Alaa Abduljabbar; Maqbool Ahmed; Fouad Al Dayel; Samar Alhomoud; Nasser Al-Sanea; Luai H Ashari; Prashant Bavi; Azhar R Hussain; Khawla S Al-Kuraya
Coexpression of activated c-Met and death receptor 5 predicts better survival in colorectal carcinoma.
The American journal of pathology 2011;179(6):3032-44.
2011: Prashant Bavi; Rong Bu; Shahab Uddin; Khawla S Al-Kuraya
MMP7 Polymorphisms - A new tool in molecular pathology to understand esophageal cancer.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2011;17(5):299-300.
2011: Prashant Bavi; Abdul K Siraj; Shahab Uddin; Nasser Al-Sanea; Luai H Ashari; Alaa Abduljabbar; Jehad Abubaker; Fouad Al Dayel; Samar Alhomoud; Khawla S Al-Kuraya
Clinico-pathological significance of TNF alpha-induced protein3 (TNFAIP3) in Middle Eastern colorectal carcinoma.
Clinical epigenetics 2011;2(2):417-8.
2011: Prashant Bavi; Rong Bu; Azhar R Hussain; Zeeshan Qadri; Shahab Uddin; Jehad Abubaker; Maqbool Ahmed; Dahish Ajarim; Fouad Al Dayel; Valorie Balde; Khawla S Al-Kuraya
The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL).
The Journal of pathology 2011;224(3):355-66.
2011: Shahab Uddin; Khawla S Al-Kuraya
Localization of death receptor 4 in lipid rafts sensitizes chronic lymphocytic leukemia to chemotherapeutic drug mediated apoptosis.
Leukemia & lymphoma 2011;52(7):1176-7.
2011: Prashant Bavi; Shahab Uddin; Maqbool Ahmed; Zeenath Jehan; Rong Bu; Jehad Abubaker; Mehar Sultana; Nasser Al-Sanea; Alaa Abduljabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Sarita Prabhakaran; Azhar R Hussain; Khawla S Al-Kuraya
Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma.
The American journal of pathology 2011;178(5):2109-20.
2011: Azhar R Hussain; Maqbool Ahmed; Saeeda Ahmed; Pulicat Manogaran; Leonidas C Platanias; Syed N Alvi; Khawla S Al-Kuraya; Shahab Uddin
Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma.
Free radical biology & medicine 2011;50(8):978-87.
2011: Shahab Uddin; Maqbool Ahmed; Azhar Hussain; Jehad Abubaker; Nasser Al-Sanea; Alaa AbdulJabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Zeenath Jehan; Prashant Bavi; Abdul K Siraj; Khawla S Al-Kuraya
Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.
The American journal of pathology 2011;178(2):537-47.
2011: Shahab Uddin; Prashant Bavi; Azhar R Hussain; Omar S Khan; Abdul K Siraj; Khawla S Al-Kuraya
Role of leptin and its receptors in the pathogenesis of thyroid cancer.
International journal of clinical and experimental pathology 2011;4(7):637-43.
2011: Azhar R Hussain; Omar S Khan; Shahab Uddin; Maqbool Ahmed; Saeeda O Ahmed; Rong Bu; Khawla S Al-Kuraya
Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines.
PloS one 2011;6(9):e24703.
2011: Rong Bu; Shahab Uddin; Prashant Bavi; Azhar R Hussain; Fouad Al Dayel; Samir Ghourab; Maqbool Ahmed; Khawla S Al-Kuraya
HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2011;91(1):124-37.
2010: Azhar R Hussain; Shahab Uddin; Maqbool Ahmed; Rong Bu; Saeeda O Ahmed; Jehad Abubaker; Mehar Sultana; Dahish Ajarim; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya
Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.
The Journal of pathology 2010;222(2):180-90.
2010: Shahab Uddin; Azhar R Hussain; Maqbool Ahmed; Fouad Al Dayel; Rong Bu; Prashant Bavi; Khawla S Al-Kuraya
Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma.
Laboratory investigation; a journal of technical methods and pathology 2010;90(9):1346-56.
2010: Shahab Uddin; Rong Bu; Maqbool Ahmed; Azhar R Hussain; Dahish Ajarim; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya
Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma.
Leukemia & lymphoma 2010;51(7):1305-14.
2010: Shahab Uddin; Azhar R Hussain; Maqbool Ahmed; Rong Bu; Saeeda O Ahmed; Dahish Ajarim; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya
Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma.
Molecular cancer therapeutics 2010;9(5):1244-55.
2010: A R Hussain; A S Khan; S O Ahmed; M Ahmed; L C Platanias; Khawla S Al-Kuraya; Shahab Uddin
Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells.
Cell proliferation 2010;43(2):170-83.
2010: Shahab Uddin; Prashant Bavi; Abdul K Siraj; Maqbool Ahmed; Maha Al-Rasheed; Azhar R Hussain; Mohammed Ahmed; Tarek Amin; Ali S Alzahrani; Fouad Al Dayel; Jehad Abubaker; Rong Bu; Khawla S Al-Kuraya
Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma.
Endocrine-related cancer 2010;17(1):191-202.
2010: Shahab Uddin; Maqbool Ahmed; Azhar Hussain; Lina Assad; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya; Adnan Munkarah
Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer.
International journal of cancer. Journal international du cancer 2010;126(2):382-94.
2010: Prashant Bavi; Sarita E Prabhakaran; Jehad Abubaker; Zeeshan Qadri; Thara George; Nasser Al-Sanea; Alaa Abduljabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Azhar R Hussain; Shahab Uddin; Khawla S Al-Kuraya
Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations.
Molecular cancer 2010;9():203.
2009: Jehad Abubaker; Prashant Bavi; Wael Al-Haqawi; Mehar Sultana; Sayer Al-Harbi; Nasser Al-Sanea; Alaa Abduljabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Shahab Uddin; Khawla S Al-Kuraya
Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma.
The Journal of pathology 2009;219(4):435-45.
2009: Zeenath Jehan; Prashant Bavi; Mehar Sultana; Jehad Abubaker; Rong Bu; Azhar Hussain; Ghazi Alsbeih; Nasser Al-Sanea; Alaa Abduljabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Shahab Uddin; Khawla S Al-Kuraya
Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.
The Journal of pathology 2009;219(3):337-46.
2009: Shahab Uddin; Prashant Bavi; Azhar R Hussain; Ghazi Alsbeih; Nasser Al-Sanea; Alaa Abduljabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Maqbool Ahmed; Khawla S Al-Kuraya
Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication.
Carcinogenesis 2009;30(11):1832-40.
2009: Khawla S Al-Kuraya
KRAS and TP53 mutations in colorectal carcinoma.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2009;15(4):217-9.
2009: Shahab Uddin; Maqbool Ahmed; Azhar R Hussain; Zeenath Jehan; Fouad Al Dayel; Adnan Munkarah; Prashant Bavi; Khawla S Al-Kuraya
Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer.
Laboratory investigation; a journal of technical methods and pathology 2009;89(10):1115-27.
2009: Azhar R Hussain; Maqbool Ahmed; Saeeda O Ahmed; Sara Al-Thari; Asma S Khan; Shirin Razack; Leonidas C Platanias; Khawla S Al-Kuraya; Shahab Uddin
Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells.
Leukemia & lymphoma 2009;50(7):1204-13.
2009: Shahab Uddin; Azhar R Hussain; Maqbool Ahmed; Jehad Abubaker; Nasser Al-Sanea; Alaa Abduljabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya
High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.
The American journal of gastroenterology 2009;104(7):1790-801.
2009: Shahab Uddin; Rong Bu; Maqbool Ahmed; Jehad Abubaker; Fouad Al Dayel; Prashant Bavi; Khawla S Al-Kuraya
Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.
Molecular cancer 2009;8():74.
2009: Jehad Abubaker; Prashant Bavi; Wael Al-Haqawi; Zeenath Jehan; Adnan Munkarah; Shahab Uddin; Khawla S Al-Kuraya
PIK3CA alterations in Middle Eastern ovarian cancers.
Molecular cancer 2009;8():51.
2009: Shahab Uddin; Asma S Khan; Khawla S Al-Kuraya
Developing curcumin into a viable therapeutic for lymphoma.
Expert opinion on investigational drugs 2009;18(1):57-67.
2008: Shahab Uddin; A Hussain; M Ahmed; Asim F Belgaumi; Fouad Al Dayel; Dahish Ajarim; Prashant Bavi; Khawla S Al-Kuraya
S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma.
The Journal of pathology 2008;216(4):483-94.
2008: Azhar R Hussain; Maqbool Ahmed; Naif A Al-Jomah; Asma S Khan; Pulicat Manogaran; Mehar Sultana; Jehad Abubaker; Leonidas C Platanias; Khawla S Al-Kuraya; Shahab Uddin
Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines.
Molecular cancer therapeutics 2008;7(10):3318-29.
2008: Shahab Uddin; Abdul K Siraj; Maha Al-Rasheed; Maqbool Ahmed; Rong Bu; Jeffrey N Myers; Abdulrahman Al-Nuaim; Saif Al-Sobhi; Fouad Al Dayel; Prashant Bavi; Azhar R Hussain; Khawla S Al-Kuraya
Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.
The Journal of clinical endocrinology and metabolism 2008;93(10):4088-97.
2008: Jehad Abubaker; P Bavi; S Al-Harbi; M Ibrahim; Abdul K Siraj; Nasser Al-Sanea; A Abduljabbar; L H Ashari; S Alhomoud; Fouad Al Dayel; Shahab Uddin; Khawla S Al-Kuraya
Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.
Oncogene 2008;27(25):3539-45.
2008: Prashant Bavi; Jehad Abubaker; Azhar Hussain; Meher Sultana; Fouad Al Dayel; Shahab Uddin; Khawla S Al-Kuraya
Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma.
Human pathology 2008;39(6):885-94.
2008: Shahab Uddin; Maqbool Ahmed; Prashant Bavi; Raafat El-Sayed; Nasser Al-Sanea; Alaa AbdulJabbar; Luai H Ashari; Samar Alhomoud; Fouad Al Dayel; Azhar R Hussain; Khawla S Al-Kuraya
Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.
Cancer research 2008;68(9):3379-88.
2008: Jehad Abubaker; Zeenath Jehan; Prashant Bavi; Mehar Sultana; Sayer Al-Harbi; Muna Ibrahim; Abdulrahman Al-Nuaim; Mohammed Ahmed; Tarek Amin; Maha Al-Fehaily; Osama Al-Sanea; Fouad Al Dayel; Shahab Uddin; Khawla S Al-Kuraya
Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population.
The Journal of clinical endocrinology and metabolism 2008;93(2):611-8.
2008: Zeenath Jehan; Abdul K Siraj; Jehad Abubaker; Christian Ruiz; Ronald Simon; Mehar Sultana; Shahab Uddin; Prashant Bavi; Azhar Hussain; Shirin Razack; Adnan Ezzat; Fouad Al Dayel; Guido Sauter; Khawla S Al-Kuraya
Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma.
Oncology 2008;75(1-2):71-80.
2008: Prashant Bavi; Jehad A Abubaker; Zeenath D Jehan; Naif A Al-Jomah; Abdul K Siraj; Sayer R Al-Harbi; Valerie Atizado; Alaa S Abduljabbar; Samar J Alhomoud; Luai H Ashari; Fouad H Al-Dayel; Shahab Uddin; Khawla S Al-Kuraya; Nasser A Alsanea
Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways.
Saudi medical journal 2008;29(1):75-80.
2007: Abdul K Siraj; Prashant Bavi; Jehad Abubaker; Zeenath Jehan; M Sultana; Fouad Al Dayel; A Al-Nuaim; Ali S Alzahrani; M Ahmed; O Al-Sanea; Shahab Uddin; Khawla S Al-Kuraya
Genome-wide expression analysis of Middle Eastern papillary thyroid cancer reveals c-MET as a novel target for cancer therapy.
The Journal of pathology 2007;213(2):190-9.
2007: Azhar R Hussain; Naif A Al-Jomah; Abdul K Siraj; Pulicat S Manogaran; Khalid Al-Hussein; Jehad Abubaker; Leonidas C Platanias; Khawla S Al-Kuraya; Shahab Uddin
Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.
Cancer research 2007;67(8):3888-97.
2006: Shahab Uddin; Azhar R Hussain; Abdul K Siraj; Pulicat S Manogaran; Naif A Al-Jomah; Azadali Moorji; Valerie Atizado; Fouad Al Dayel; Asim F Belgaumi; Hassan El-Solh; Adnan Ezzat; Prashant Bavi; Khawla S Al-Kuraya
Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival.
Blood 2006;108(13):4178-86.
2006: Khawla S Al-Kuraya; Prashant Bavi; Adnan Ezzat; Fouad Al Dayel; Shahab Uddin; Valerie Atizado; Naif A Al-Jomah; Samir S Amr; Salwa S Sheikh; Guido Sauter; Ronald Simon
Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis.
Saudi medical journal 2006;27(3):323-8.
2005: Khawla S Al-Kuraya; Abdul K Siraj; Fouad Al Dayel; Adnan Ezzat; Naif Al-Jommah; Valerie Atizado; rajeswari narayanappa
Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases.
Saudi medical journal 2005;26(7):1099-103.
2005: Khawla S Al-Kuraya; Kishor G Bhatia
Wingless signaling pathway family relation to colon cancer. Have we come full circle?
Saudi medical journal 2005;26(1):19-23.
2004: Coya Tapia; Peter Schraml; Ronald Simon; Khawla S Al-Kuraya; Robert Maurer; Martina Mirlacher; Hedvika Novotny; Hanspeter Spichtin; Michael J Mihatsch; Guido Sauter
HER2 analysis in breast cancer: reduced immunoreactivity in FISH non-informative cancer biopsies.
International journal of oncology 2004;25(6):1551-7.