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Paula Witt-Enderby

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Paula Witt-Enderby; Corry D Bondi; William P Clafshenkel; Balasunder R Dodda; Katie M Gallagher; Suzanne Higginbotham; Nakpangi A Johnson; Mary P Kotlarczyk; James Louis Rutkowski; Shalini Sethi; John P Slater; Vicki L Davis
Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice.
William P Clafshenkel; Ellen S Gawalt; Ken A McGowan; Rachelle N Palchesko; Jared D Romeo; James Louis Rutkowski; Paula Witt-Enderby
A novel calcium aluminate-melatonin scaffold enhances bone regeneration within a calvarial defect.
Mary P Kotlarczyk; HC Lassila; Christine K O'Neil; Paula Witt-Enderby; Frank D'Amico; Larry T Enderby; Judith L Balk
Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women.

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All Publications

2012: Paula Witt-Enderby; Corry D Bondi; William P Clafshenkel; Balasunder R Dodda; Katie M Gallagher; Suzanne Higginbotham; Nakpangi A Johnson; Mary P Kotlarczyk; James Louis Rutkowski; Shalini Sethi; John P Slater; Vicki L Davis
Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice.
Journal of pineal research 2012;53(4):374-84.
2012: William P Clafshenkel; Ellen S Gawalt; Ken A McGowan; Rachelle N Palchesko; Jared D Romeo; James Louis Rutkowski; Paula Witt-Enderby
A novel calcium aluminate-melatonin scaffold enhances bone regeneration within a calvarial defect.
Journal of pineal research 2012;53(2):206-18.
2012: Mary P Kotlarczyk; HC Lassila; Christine K O'Neil; Paula Witt-Enderby; Frank D'Amico; Larry T Enderby; Judith L Balk
Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women.
Journal of pineal research 2012;52(4):414-26.
2012: William P Clafshenkel; J Mark Cline; Vicki L Davis; Warren G Foster; Tracy L King; Mary P Kotlarczyk; Paula Witt-Enderby
Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():487423.
2011: Christian Markl; Shalini Sethi; Paula Witt-Enderby; Mohamed I Attia; William P Clafshenkel; Darius P Zlotos
N-Acetyl-5-arylalkoxytryptamine analogs: probing the melatonin receptors for MT(1) -selectivity.
Archiv der Pharmazie 2011;344(10):666-74.
2009: Christian Markl; Mohamed I Attia; Justin Julius; Shalini Sethi; Paula Witt-Enderby; Darius P Zlotos
Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands.
Bioorganic & medicinal chemistry 2009;17(13):4583-94.
2009: Michael J Jarzynka; Deepshikha K Passey; David A Johnson; Nagarjun V Konduru; Nicholas F Fitz; Nicholas M Radio; Mark M Rasenick; Susan Benloucif; Melissa A Melan; Paula Witt-Enderby
Microtubules modulate melatonin receptors involved in phase-shifting circadian activity rhythms: in vitro and in vivo evidence.
Journal of pineal research 2009;46(2):161-71.
2009: Darius P Zlotos; Mohamed I Attia; Justin Julius; Shalini Sethi; Paula Witt-Enderby
2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists.
Journal of medicinal chemistry 2009;52(3):826-33.
2009: Stephen G Grant; Melissa A Melan; Jean J Latimer; Paula Witt-Enderby
Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives.
Expert reviews in molecular medicine 2009;11():e5.
2008: Shalini Sethi; Wendy Adams; John Pollock; Paula Witt-Enderby
C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes.
Journal of pineal research 2008;45(2):212-8.
2008: Mohamed I Attia; Paula Witt-Enderby; Justin Julius
Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands.
Bioorganic & medicinal chemistry 2008;16(16):7654-61.
2008: C Dominic Bondi; Raelene M McKeon; Jennifer M Bennett; Paul F Ignatius; Lena Brydon; Ralf JOckers; Melissa A Melan; Paula Witt-Enderby
MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation.
Journal of pineal research 2008;44(3):288-98.
2007: Mohamed I Attia; Deniz Güclü; Barbara Hertlein; Justin Julius; Paula Witt-Enderby; Darius P Zlotos
Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a']diindole analogues as melatonin receptor ligands.
Organic & biomolecular chemistry 2007;5(13):2129-37.
2006: Michael J Jarzynka; Deepshikha K Passey; Paul F Ignatius; Melissa A Melan; Nicholas M Radio; Ralf JOckers; Mark M Rasenick; Lena Brydon; Paula Witt-Enderby
Modulation of melatonin receptors and G-protein function by microtubules.
Journal of pineal research 2006;41(4):324-36.
2006: Paula Witt-Enderby; Nicholas M Radio; John S Doctor; Vicki L Davis
Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy.
Journal of pineal research 2006;41(4):297-305.
2006: Nicholas M Radio; John S Doctor; Paula Witt-Enderby
Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade.
Journal of pineal research 2006;40(4):332-42.
2006: Christopher K Surratt; Paula Witt-Enderby; David A Johnson; Carl A Anderson; J Douglas Bricker; Vicki L Davis; Steven M Firestine; Wilson S Meng
Development of a neuroscience-oriented "methods" course for graduate students of pharmacology and toxicology.
CBE life sciences education 2006;5(2):188-96.
2004: Paula Witt-Enderby; Michael J Jarzynka; B J Krawitt; Melissa A Melan
Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization.
Life sciences 2004;75(22):2703-15.
2003: Paula Witt-Enderby; Jennifer Bennett; Michael J Jarzynka; Steven M Firestine; Melissa A Melan
Melatonin receptors and their regulation: biochemical and structural mechanisms.
Life sciences 2003;72(20):2183-98.
2003: Monica I Masana; Paula Witt-Enderby; Margarita L Dubocovich
Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal.
Biochemical pharmacology 2003;65(5):731-9.
2002: Renee S MacKenzie; Melissa A Melan; Deepshikha K Passey; Paula Witt-Enderby
Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.
Biochemical pharmacology 2002;63(4):587-95.
2002: Guo-Hua Chu; Paula Witt-Enderby; Marla Jones; L Pui-Kai
Synthesis and pharmacological analysis of high affinity melatonin receptor ligands.
Chemical & pharmaceutical bulletin 2002;50(2):272-5.
2001: Jeffrey W Clemens; Michael J Jarzynka; Paula Witt-Enderby
Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure.
Life sciences 2001;69(1):27-35.
2001: S L Bordt; R M McKeon; Pui-Kai Li; Paula Witt-Enderby; Melissa A Melan
N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin.
Biochimica et biophysica acta 2001;1499(3):257-64.
2000: Paula Witt-Enderby; R S MacKenzie; R M McKeon; E A Carroll; S L Bordt; Melissa A Melan
Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor.
Cell motility and the cytoskeleton 2000;46(1):28-42.
2000: M P Jones; Melissa A Melan; Paula Witt-Enderby
Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner.
Cancer letters 2000;151(2):133-43.
2000: Paula Witt-Enderby; Pui-Kai Li
Melatonin receptors and ligands.
Vitamins and hormones 2000;58():321-54.
1998: Paula Witt-Enderby; Monica I Masana; Margarita L Dubocovich
Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor.
Endocrinology 1998;139(7):3064-71.
1997: Paula Witt-Enderby; Guo-Hua Chu; M L Gillen; Pui-Kai Li
Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors.
Journal of medicinal chemistry 1997;40(26):4195-8.
1996: Paula Witt-Enderby; Margarita L Dubocovich
Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.
Molecular pharmacology 1996;50(1):166-74.
1995: Paula Witt-Enderby; Henry I Yamamura; Marilyn Halonen; Josephine Lai; J D Palmer; John W Bloom
Regulation of airway muscarinic cholinergic receptor subtypes by chronic anticholinergic treatment.
Molecular pharmacology 1995;47(3):485-90.
1993: Paula Witt-Enderby; Henry I Yamamura; Marilyn Halonen; J D Palmer; John W Bloom
Chronic exposure to a beta 2-adrenoceptor agonist increases the airway response to methacholine.
European journal of pharmacology 1993;241(1):121-3.