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David Weber

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TOP 3
Danna Zimmer; Rena Lapidus; David Weber
In vivo screening of S100B inhibitors for melanoma therapy.
Kira G Hartman; Melissa A Liriano; Laura E McKnight; David Weber
The evolution of S100B inhibitors for the treatment of malignant melanoma.
Melissa A Liriano; Eric A Toth; Kristen M Varney; Cassandra L Hoffman; Rieko Ishima; Neil T Wright; David Weber
Target binding to S100B reduces dynamic properties and increases Ca(2+)-binding affinity for wild type and EF-hand mutant proteins.

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All Publications

2013: Danna Zimmer; Rena Lapidus; David Weber
In vivo screening of S100B inhibitors for melanoma therapy.
Methods in molecular biology (Clifton, N.J.) 2013;963():303-17.
2013: Kira G Hartman; Melissa A Liriano; Laura E McKnight; David Weber
The evolution of S100B inhibitors for the treatment of malignant melanoma.
Future medicinal chemistry 2013;5(1):97-109.
2012: Melissa A Liriano; Eric A Toth; Kristen M Varney; Cassandra L Hoffman; Rieko Ishima; Neil T Wright; David Weber
Target binding to S100B reduces dynamic properties and increases Ca(2+)-binding affinity for wild type and EF-hand mutant proteins.
Journal of molecular biology 2012;423(3):365-85.
2011: Zhenghong Xu; Wenbo Yu; Alexander D. Mackerell; David Weber; Paul T Wilder; Aruna Battu; Karl X Chai; Li-Mei Chen; Ya-Wen Chen; Michael D Johnson; Chen-Yong Lin
Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.
Journal of medicinal chemistry 2011;54(21):7567-78.
2011: Reniqua P House; Zhong-Hua Li; Purvi Patel; Maria Pozzuto; Michele Vitolo; David Weber; Wendy D Zencheck; Natalya G Dulyaninova; Anne R Bresnick
Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion.
Biochemistry 2011;50(32):6920-32.
2011: Naohiro Yamaguchi; Benjamin Prosser; Farshid Ghassemi; Le Xu; Daniel A Pasek; Jerry P Eu; Erick O Hernández-Ochoa; Brian R Cannon; Paul T Wilder; Richard M Lovering; David Weber; Werner Melzer; Martin F Schneider; Gerhard Meissner
Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.
American journal of physiology. Cell physiology 2011;300(5):C998-C1012.
2010: Jing Lin; Qingyuan Yang; Paul T Wilder; France Carrier; David Weber
The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma.
The Journal of biological chemistry 2010;285(35):27487-98.
2010: M B Weiss; Michele Vitolo; M Mohseni; D M Rosen; Samuel R Denmeade; Ben Ho Park; David Weber; Kurtis E Bachman
Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response.
Oncogene 2010;29(33):4715-24.
2010: Benoît Gilquin; Brian R Cannon; Arnaud Hubstenberger; Boualem Moulouel; Elin Falk; Nicolas Merle; Nicole Assard; Sylvie Kieffer; Denis Rousseau; Paul T Wilder; David Weber; jacques Baudier
The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A.
Molecular and cellular biology 2010;30(11):2724-36.
2010: Vladimir N Malashkevich; Natalya G Dulyaninova; Udupi A Ramagopal; Melissa A Liriano; Kristen M Varney; David Knight; Michael Brenowitz; David Weber; Steven C Almo; Anne R Bresnick
Phenothiazines inhibit S100A4 function by inducing protein oligomerization.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(19):8605-10.
2010: Thomas H Charpentier; Laura E Thompson; Melissa A Liriano; Kristen M Varney; Paul T Wilder; Edvin Pozharskiy; Eric A Toth; David Weber
The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography.
Journal of molecular biology 2010;396(5):1227-43.
2010: Jason Smith; Benjamin J Stewart; Sharon Glaysher; Katharine Peregrin; Louise A Knight; David Weber; Ian Cree
The effect of pentamidine on melanoma ex vivo.
Anti-cancer drugs 2010;21(2):181-5.
2010: Danna Zimmer; David Weber
The Calcium-Dependent Interaction of S100B with Its Protein Targets.
Cardiovascular psychiatry and neurology 2010;2010():.
2009: Michele Vitolo; Michele B Weiss; Marta Szmacinski; Khola Tahir; Todd Waldman; Ben Ho Park; Stuart S Martin; David Weber; Kurtis E Bachman
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.
Cancer research 2009;69(21):8275-83.
2009: Erick Hernandez-Ochoa; Benjamin Prosser; Neil T Wright; Minerva Contreras; David Weber; Martin F Schneider
Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons.
American journal of physiology. Cell physiology 2009;297(4):C955-70.
2009: Thomas H Charpentier; Paul T Wilder; Melissa A Liriano; Kristen M Varney; Shijun Zhong; Andrew Coop; Edvin Pozharskiy; Alexander D. Mackerell; Eric A Toth; David Weber
Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography.
Biochemistry 2009;48(26):6202-12.
2009: Nathan T Wright; Brian Cannon; Paul T Wilder; Michael T Morgan; Kristen M Varney; Danna Zimmer; David Weber
Solution structure of S100A1 bound to the CapZ peptide (TRTK12).
Journal of molecular biology 2009;386(5):1265-77.
2008: Nathan T Wright; Keith G Inman; Jonathan A Levine; Brian Cannon; Kristen M Varney; David Weber
Refinement of the solution structure and dynamic properties of Ca(2+)-bound rat S100B.
Journal of biomolecular NMR 2008;42(4):279-86.
2008: Nathan T Wright; Benjamin Prosser; Kristen M Varney; Danna Zimmer; Martin F Schneider; David Weber
S100A1 and calmodulin compete for the same binding site on ryanodine receptor.
The Journal of biological chemistry 2008;283(39):26676-83.
2008: Thomas H Charpentier; Paul T Wilder; Melissa A Liriano; Kristen M Varney; Edvin Pozharskiy; Alexander D. Mackerell; Andrew Coop; Eric A Toth; David Weber
Divalent metal ion complexes of S100B in the absence and presence of pentamidine.
Journal of molecular biology 2008;382(1):56-73.
2008: Vladimir N Malashkevich; Kristen M Varney; Sarah C. Garrett; Paul T Wilder; David Knight; Thomas H Charpentier; Udupi A Ramagopal; Steven C Almo; David Weber; Anne R Bresnick
Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA.
Biochemistry 2008;47(18):5111-26.
2008: Benjamin Prosser; Nathan T Wright; Erick O Hernãndez-Ochoa; Kristen M Varney; Yewei Liu; Oluwarotim Rotimi Olojo; Danna Zimmer; David Weber; Martin F Schneider
S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling.
The Journal of biological chemistry 2008;283(8):5046-57.
2008: Dalin Rifat; Nathan T Wright; Kristen M Varney; David Weber; Lindsay W Black
Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target.
Journal of molecular biology 2008;375(3):720-34.
2007: Jorge J Velarde; Kristen M Varney; Keith G Inman; Mauricio Farfan; Edward G Dudley; Jonathan Fletcher; David Weber; James P Nataro
Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli.
Molecular microbiology 2007;66(5):1123-35.
2007: Mordecai P Blaustein; Thomas H Charpentier; David Weber
Getting a grip on calcium regulation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18349-50.
2007: Paul T Wilder; Thomas H Charpentier; David Weber
Hydrocarbon-stapled helices: a novel approach for blocking protein-protein interactions.
ChemMedChem 2007;2(8):1149-51.
2007: Joseph Markowitz; Alexander D. Mackerell; David Weber
A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins.
Mini reviews in medicinal chemistry 2007;7(6):609-16.
2006: Paul T Wilder; Jing Lin; Catherine L Bair; Thomas H Charpentier; Dong Yang; Melissa Liriano; Kristen M Varney; Andrew Lee; Amos B Oppenheim; Sankar Adhya; France Carrier; David Weber
Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.
Biochimica et biophysica acta 2006;1763(11):1284-97.
2006: Hong Song; Moo Yeol Lee; Stephen P Kinsey; David Weber; Mordecai P Blaustein
An N-terminal sequence targets and tethers Na+ pump alpha2 subunits to specialized plasma membrane microdomains.
The Journal of biological chemistry 2006;281(18):12929-40.
2006: Sarah C. Garrett; Kristen M Varney; David Weber; Anne R Bresnick
S100A4, a mediator of metastasis.
The Journal of biological chemistry 2006;281(2):677-80.
2006: Ruiqing Yang; David Weber; France Carrier
Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.
Nucleic acids research 2006;34(4):1224-36.
2005: Nathan T Wright; Kristen M Varney; Karen C Ellis; Joseph Markowitz; Rossitza K Gitti; Danna Zimmer; David Weber
The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy.
Journal of molecular biology 2005;353(2):410-26.
2005: Nathan T Wright; Joyce W Margolis; Frank L Margolis; David Weber
Refinement of the solution structure of rat olfactory marker protein (OMP).
Journal of biomolecular NMR 2005;33(1):63-8.
2005: Rossitza K Gitti; Nathan T Wright; Joyce W Margolis; Kristen M Varney; David Weber; Frank L Margolis
Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements.
Biochemistry 2005;44(28):9673-9.
2005: Joseph Markowitz; Richard R Rustandi; Kristen M Varney; Paul T Wilder; Ryan Udan; Su Ling Wu; William DeW Horrocks; David Weber
Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53.
Biochemistry 2005;44(19):7305-14.
2005: Paul T Wilder; Kristen M Varney; Michele B Weiss; Rossitza K Gitti; David Weber
Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy.
Biochemistry 2005;44(15):5690-702.
2005: Joseph Markowitz; Alexander D. Mackerell; France Carrier; Thomas H Charpentier; David Weber
Design of Inhibitors for S100B.
Current topics in medicinal chemistry 2005;5(12):1093-108.
2004: Joseph Markowitz; Ijen Chen; Rossitza K Gitti; Donna M Baldisseri; Yongping Pan; Ryan Udan; France Carrier; Alexander D. Mackerell; David Weber
Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction.
Journal of medicinal chemistry 2004;47(21):5085-93.
2004: Jing Lin; Qingyuan Yang; Zhe Yan; Joseph Markowitz; Paul T Wilder; France Carrier; David Weber
Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells.
The Journal of biological chemistry 2004;279(32):34071-7.
2003: Paul T Wilder; Donna M Baldisseri; Ryan Udan; Kristen M Vallely; David Weber
Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis.
Biochemistry 2003;42(46):13410-21.
2003: Kui Xu; Charles Belunis; Wei Chu; David Weber; Frank Podlaski; Kuo-Sen Huang; Steven I Reed; Lyubomir T Vassilev
Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase.
The Biochemical journal 2003;371(Pt 3):957-64.
2003: Danna Zimmer; Patti Wright Sadosky; David Weber
Molecular mechanisms of S100-target protein interactions.
Microscopy research and technique 2003;60(6):552-9.
2002: Keith G Inman; Ruiqing Yang; Richard R Rustandi; Kristine E Miller; Donna M Baldisseri; David Weber
Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.
Journal of molecular biology 2002;324(5):1003-14.
2002: Kristen M Vallely; Richard R Rustandi; Karen C Ellis; Olga Varlamova; Anne R Bresnick; David Weber
Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy.
Biochemistry 2002;41(42):12670-80.
2002: Donna M Baldisseri; Joyce W Margolis; David Weber; Jae Hyung Koo; Frank L Margolis
Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.
Journal of molecular biology 2002;319(3):823-37.
2002: Pete Dunten; Charles Belunis; Robert Crowther; Kurt Hollfelder; Ursula Kammlott; Wayne Levin; Hanspeter Michel; Gwendolyn Ramsey; Amy Swain; David Weber; Stanley J Wertheimer
Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
Journal of molecular biology 2002;316(2):257-64.
2002: Richard R Rustandi; Donna M Baldisseri; Keith G Inman; Peter Nizner; Shannon M Hamilton; Aimee Landar; Alexander Landar; Danna Zimmer; David Weber
Three-dimensional solution structure of the calcium-signaling protein apo-S100A1 as determined by NMR.
Biochemistry 2002;41(3):788-96.
2001: Jing Lin; Mellissa Blake; C Tang; Danna Zimmer; Richard R Rustandi; David Weber; France Carrier
Inhibition of p53 transcriptional activity by the S100B calcium-binding protein.
The Journal of biological chemistry 2001;276(37):35037-41.
2001: Karen C Ellis; TC Tenenholz; H Jerng; M Hayhurst; C S Dudlak; W F Gilly; Mordecai P Blaustein; David Weber
Interaction of a toxin from the scorpion Tityus serrulatus with a cloned K+ channel from squid (sqKv1A).
Biochemistry 2001;40(20):5942-53.
2001: Richard R Rustandi; Kristen M Vallely; Olga Varlamova; M G Klein; Steven C Almo; Anne R Bresnick; David Weber
1H, 13C, 15N NMR sequence-specific resonance assignments for human apo-Mts1 (S100A4).
Journal of biomolecular NMR 2001;19(4):381-2.
2001: Keith G Inman; Donna M Baldisseri; K E Miller; David Weber
Backbone dynamics of the calcium-signaling protein apo-S100B as determined by 15N NMR relaxation.
Biochemistry 2001;40(12):3439-48.
2000: Michael Andrec; K G Inman; David Weber; Ronald M Levy; Gaetano T Montelione
A Bayesian statistical method for the detection and quantification of rotational diffusion anisotropy from NMR relaxation data.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2000;146(1):66-80.
2000: Richard R Rustandi; Donna M Baldisseri; David Weber
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
Nature structural biology 2000;7(7):570-4.
2000: David R Bolin; A L Swain; Ramakanth Sarabu; Steven J Berthel; PB Gillespie; Nicholas Huby; R Makofske; L Orzechowski; A Perrotta; K Toth; J P Cooper; N Jiang; F Falcioni; Robert Campbell; D Cox; D Gaizband; Charles Belunis; D Vidovic; K Ito; Robert Crowther; Ursula Kammlott; X Zhang; R Palermo; David Weber; J Guenot; Z Nagy; Gary L Olson
Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
Journal of medicinal chemistry 2000;43(11):2135-48.
2000: K C Klenk; TC Tenenholz; Donald R Matteson; RS Rogowski; Mordecai P Blaustein; David Weber
Structural and functional differences of two toxins from the scorpion Pandinus imperator.
Proteins 2000;38(4):441-9.
2000: TC Tenenholz; K C Klenk; Donald R Matteson; Mordecai P Blaustein; David Weber
Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides.
Reviews of physiology, biochemistry and pharmacology 2000;140():135-85.
1999: Richard R Rustandi; Donna M Baldisseri; Alexander C Drohat; David Weber
Structural changes in the C-terminus of Ca2+-bound rat S100B (beta beta) upon binding to a peptide derived from the C-terminal regulatory domain of p53.
Protein science : a publication of the Protein Society 1999;8(9):1743-51.
1999: Donna M Baldisseri; Richard R Rustandi; Z Zhang; C Tang; C L Bair; Aimee Landar; A Landar; Danna Zimmer; David Weber
1H, 13C and 15N NMR sequence-specific resonance assignments for rat apo-S100A1(alpha alpha)
Journal of biomolecular NMR 1999;14(1):91-2.
1999: Alexander C Drohat; N Tjandra; Donna M Baldisseri; David Weber
The use of dipolar couplings for determining the solution structure of rat apo-S100B(betabeta).
Protein science : a publication of the Protein Society 1999;8(4):800-9.
1999: M Garbuglia; M Verzini; Richard R Rustandi; D Osterloh; David Weber; Volker Gerke; Rosario Donato
Role of the C-terminal extension in the interaction of S100A1 with GFAP, tubulin, the S100A1- and S100B-inhibitory peptide, TRTK-12, and a peptide derived from p53, and the S100A1 inhibitory effect on GFAP polymerization.
Biochemical and biophysical research communications 1999;254(1):36-41.
1999: Albert S Mildvan; David Weber; C Abeygunawardana
Solution structure and mechanism of the MutT pyrophosphohydrolase.
Advances in enzymology and related areas of molecular biology 1999;73():183-207.
1998: Aimee Landar; Richard R Rustandi; David Weber; Danna Zimmer
S100A1 utilizes different mechanisms for interacting with calcium-dependent and calcium-independent target proteins.
Biochemistry 1998;37(50):17429-38.
1998: Pete Dunten; Ursula Kammlott; Robert Crowther; David Weber; R Palermo; Jens Birktoft
Protein farnesyltransferase: structure and implications for substrate binding.
Biochemistry 1998;37(22):7907-12.
1998: Alexander C Drohat; Donna M Baldisseri; Richard R Rustandi; David Weber
Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy,.
Biochemistry 1998;37(9):2729-40.
1998: Paul T Wilder; Richard R Rustandi; Alexander C Drohat; David Weber
S100B(betabeta) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner.
Protein science : a publication of the Protein Society 1998;7(3):794-8.
1998: Richard R Rustandi; Alexander C Drohat; Donna M Baldisseri; Paul T Wilder; David Weber
The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53.
Biochemistry 1998;37(7):1951-60.
1997: Aimee Landar; T L Hall; E H Cornwall; J J Correia; Alexander C Drohat; David Weber; Danna Zimmer
The role of cysteine residues in S100B dimerization and regulation of target protein activity.
Biochimica et biophysica acta 1997;1343(1):117-29.
1997: D Chaudhuri; William DeW Horrocks; J C Amburgey; David Weber
Characterization of lanthanide ion binding to the EF-hand protein S100 beta by luminescence spectroscopy.
Biochemistry 1997;36(32):9674-80.
1997: Alexander C Drohat; E Nenortas; Dorothy Beckett; David Weber
Oligomerization state of S100B at nanomolar concentration determined by large-zone analytical gel filtration chromatography.
Protein science : a publication of the Protein Society 1997;6(7):1577-82.
1997: TC Tenenholz; RS Rogowski; J H Collins; Mordecai P Blaustein; David Weber
Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels.
Biochemistry 1997;36(10):2763-71.
1996: R S Rogowski; J H Collins; T J O'Neill; TA Gustafson; T R Werkman; Michael A Rogawski; T C Tenenholz; David Weber; Mordecai P Blaustein
Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels.
Molecular pharmacology 1996;50(5):1167-77.
1996: Alexander C Drohat; J C Amburgey; F Abildgaard; M R Starich; Donna M Baldisseri; David Weber
Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy.
Biochemistry 1996;35(36):11577-88.
1995: C Abeygunawardana; David Weber; Apostolos G Gittis; D N Frick; J Lin; A F Miller; Maurice J Bessman; Albert S Mildvan
Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase.
Biochemistry 1995;34(46):14997-5005.
1995: J C Amburgey; F Abildgaard; M R Starich; S Shah; D C Hilt; David Weber
1H, 13C and 15N NMR assignments and solution secondary structure of rat Apo-S100 beta.
Journal of biomolecular NMR 1995;6(2):171-9.
1995: D N Frick; David Weber; C Abeygunawardana; Apostolos G Gittis; Maurice J Bessman; Albert S Mildvan
NMR studies of the conformations and location of nucleotides bound to the Escherichia coli MutT enzyme.
Biochemistry 1995;34(16):5577-86.
1994: David Weber; A M Libson; Apostolos G Gittis; MS Lebowitz; Albert S Mildvan
NMR docking of a substrate into the X-ray structure of the Asp-21-->Glu mutant of staphylococcal nuclease.
Biochemistry 1994;33(26):8017-28.
1994: D N Frick; David Weber; J R Gillespie; Maurice J Bessman; Albert S Mildvan
Dual divalent cation requirement of the MutT dGTPase. Kinetic and magnetic resonance studies of the metal and substrate complexes.
The Journal of biological chemistry 1994;269(3):1794-803.
1993: David Weber; C Abeygunawardana; Maurice J Bessman; Albert S Mildvan
Secondary structure of the MutT enzyme as determined by NMR.
Biochemistry 1993;32(48):13081-8.
1993: C Abeygunawardana; David Weber; D N Frick; Maurice J Bessman; Albert S Mildvan
Sequence-specific assignments of the backbone 1H, 13C, and 15N resonances of the MutT enzyme by heteronuclear multidimensional NMR.
Biochemistry 1993;32(48):13071-80.
1993: W J Chuang; David Weber; Apostolos G Gittis; Albert S Mildvan
Mutational tests of the NMR-docked structure of the staphylococcal nuclease-metal-3',5'-pdTp complex.
Proteins 1993;17(1):36-48.
1993: David Weber; E H Serpersu; Apostolos G Gittis; Eaton E Lattman; Albert S Mildvan
NMR docking of the competitive inhibitor thymidine 3',5'-diphosphate into the X-ray structure of staphylococcal nuclease.
Proteins 1993;17(1):20-35.
1992: David Weber; S K Bhatnagar; L C Bullions; Maurice J Bessman; Albert S Mildvan
NMR and isotopic exchange studies of the site of bond cleavage in the MutT reaction.
The Journal of biological chemistry 1992;267(24):16939-42.
1992: David Weber; Apostolos G Gittis; G P Mullen; C Abeygunawardana; Eaton E Lattman; Albert S Mildvan
NMR docking of a substrate into the X-ray structure of staphylococcal nuclease.
Proteins 1992;13(4):275-87.
1992: Albert S Mildvan; David Weber; A Kuliopulos
Quantitative interpretations of double mutations of enzymes.
Archives of biochemistry and biophysics 1992;294(2):327-40.
1992: David Weber; P Berkowitz; M G Panek; N W Huh; Lee G Pedersen; R G Hiskey
Modifications of bovine prothrombin fragment 1 in the presence and absence of Ca(II) ions. Loss of positive cooperativity in Ca(II) ion binding for the modified proteins.
The Journal of biological chemistry 1992;267(7):4564-9.
1992: P Berkowitz; N W Huh; K E Brostrom; M G Panek; David Weber; A Tulinsky; Lee G Pedersen; R G Hiskey
A metal ion-binding site in the kringle region of bovine prothrombin fragment 1.
The Journal of biological chemistry 1992;267(7):4570-6.
1991: David Weber; G P Mullen; Albert S Mildvan
Conformation of an enzyme-bound substrate of staphylococcal nuclease as determined by NMR.
Biochemistry 1991;30(30):7425-37.
1991: David Weber; Alan K Meeker; Albert S Mildvan
Interactions of the acid and base catalysts on staphylococcal nuclease as studied in a double mutant.
Biochemistry 1991;30(25):6103-14.
1990: David Weber; E H Serpersu; David Shortle; Albert S Mildvan
Diverse interactions between the individual mutations in a double mutant at the active site of staphylococcal nuclease.
Biochemistry 1990;29(37):8632-42.
1988: Jennifer Pollock; A J Shepard; David Weber; D L Olson; David Klapper; Lee G Pedersen; R G Hiskey
Phospholipid binding properties of bovine prothrombin peptide residues 1-45.
The Journal of biological chemistry 1988;263(28):14216-23.
1988: David Weber; Jennifer Pollock; Lee G Pedersen; R G Hiskey
The determination of a calcium-dependent binding constant of the bovine prothrombin Gla domain (residues 1-45) to phospholipid vesicles.
Biochemical and biophysical research communications 1988;155(1):230-5.