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Nicholas Chiorazzi

Research Profile

Disorders

B-Cell Chronic Lymphocytic Leukemia

Anatomy

Chemicals & Drugs

Physiology

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shih-shih chen; Franak Batliwalla; Carlo M Croce; Nichol E Holodick; Thomas L Rothstein; Xiao-Jie Yan; Sophia Yancopoulos; Nicholas Chiorazzi
Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling.
Alessandra Cesano; Roberto Chignola; Nicholas Chiorazzi; Charles C Chu; Federica Cioffi; James Cordeiro; Rajendra N Damle; Erik Evensen; Rachael E Hawtin; Ornella Lovato; Ilaria Nichele; Omar Perbellini; Giovanni Pizzolo; Jason Ptacek; Kanti R Rai; Jodi R Ware; Xiao-jie Yan; Roberta Zanotti; Chiara Cavallini; Maria Teresa Scupoli
Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies.
Nicholas Chiorazzi; Dimitar G Efremov
Chronic lymphocytic leukemia: a tale of one or two signals?

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All Publications

2013: shih-shih chen; Franak Batliwalla; Carlo M Croce; Nichol E Holodick; Thomas L Rothstein; Xiao-Jie Yan; Sophia Yancopoulos; Nicholas Chiorazzi
Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):E1500-7.
2013: Alessandra Cesano; Roberto Chignola; Nicholas Chiorazzi; Charles C Chu; Federica Cioffi; James Cordeiro; Rajendra N Damle; Erik Evensen; Rachael E Hawtin; Ornella Lovato; Ilaria Nichele; Omar Perbellini; Giovanni Pizzolo; Jason Ptacek; Kanti R Rai; Jodi R Ware; Xiao-jie Yan; Roberta Zanotti; Chiara Cavallini; Maria Teresa Scupoli
Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies.
Haematologica 2013;98(4):626-34.
2013: Nicholas Chiorazzi; Dimitar G Efremov
Chronic lymphocytic leukemia: a tale of one or two signals?
Cell research 2013;23(2):182-5.
2012: Piers E M Patten; Kanti R Rai; Sergio Roa; Matthew D Scharff; Joy (Xiao-Jie) Yan; Lu Zhang; Emilia Albesiano; Steven Allen; Jacqueline Barrientos; Charles C Chu; Rajendra N Damle; Dorothy Kim; Jonathan E Kolitz; Thomas MacCarthy; Amanda R Magli; Patricia K Mongini; Nicholas Chiorazzi
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.
Blood 2012;120(24):4802-11.
2012: Rajendra N Damle; Jonathan E Kolitz; Patricia K A Mongini; Santanu Paul; Kanti R Rai; Sonal Temburni; Steven Allen; Taraneh Banapour; Nicholas Chiorazzi
T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients.
Blood 2012;120(12):2438-49.
2012: Hyunjoo Lee; Steven McCormick; Nicholas Chiorazzi; Shabirul Haque; John K Inman; Jennifer Nieto; Joshua Trott; Patricia Mongini
A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6093-108.
2012: Preetesh Jain; Mohammad Javdan; Jonathan E Kolitz; Kanti R Rai; Andreas Rosenwald; Filiz Sen; Cristina P Sison; Lynne V Abruzzo; Steven L Allen; Tawfiqul A Bhuiya; Jan A Burger; Nicholas Chiorazzi; Pui Yan Chiu; Rajendra N Damle; Franziska K Feger; Barbara Sherry
Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance.
Haematologica 2012;97(4):599-607.
2012: Kwan-Ki Hwang; Daniel M Kozink; Hua-Xin Liao; Micah A Luftig; Dawn J Marshall; John F Whitesides; Xiao-Jie Yan; Rosa Catera; Xi Chen; Charles C Chu; Marietta Gustilo; Barton F Haynes; Nicholas Chiorazzi
Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells.
Blood 2012;119(7):e35-44.
2012: Sabine Ponader; William G Wierda; Kumudha Balakrishnan; Joseph J Buggy; shih-shih chen; Nicholas Chiorazzi; Varsha Gandhi; Michael J Keating; Susan O'Brien; Jan A Burger
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.
Blood 2012;119(5):1182-9.
2012: Nicholas Chiorazzi
Implications of new prognostic markers in chronic lymphocytic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2012;2012():76-87.
2011: Xiao-Jie Yan; Sophia Yancopoulos; Cristina Sison; Steven L Allen; Michael Centola; Nicholas Chiorazzi; Igor Dozmorov; Preetesh Jain; Jonathan E Kolitz; Wentian Li; Kanti R Rai; Barbara Sherry
Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia.
Blood 2011;118(19):5201-10.
2011: Igor Dozmorov; Elizabeth Drewe; Guthridge Joel; James Jarvis; Ivona Aksentijevich; Doris M Benbrook; Michael Centola; Nicholas Chiorazzi; John Ryan; Ricardo Saban; Patrick J Tighe; Edward Wakeland; Ivan Lefkovits
Internal standard-based analysis of microarray data2--analysis of functional associations between HVE-genes.
Nucleic acids research 2011;39(18):7881-99.
2011: Fabio Malavasi; Giovanna Cutrona; Rajendra N Damle; Silvia Deaglio; Manlio Ferrarini; Nicholas Chiorazzi
CD38 and chronic lymphocytic leukemia: a decade later.
Blood 2011;118(13):3470-8.
2011: Davide Bagnara; Matthew Kaufman; Carlo Calissano; Sonia Marsilio; Piers E M Patten; Rita Simone; Philip Chum; Joy (Xiao-Jie) Yan; Steven Allen; Jonathan E Kolitz; Sivasubramanian Baskar; Christoph Rader; Hakan Mellstedt; Hodjattallah Rabbani; Annette Lee; Peter K Gregersen; Kanti R Rai; Nicholas Chiorazzi
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease.
Blood 2011;117(20):5463-72.
2011: Nino Porakishvili; Azka Memon; Ketki Vispute; Nina Kulikova; Edward A Clark; Kanti R Rai; Amit Nathwani; Rajendra N Damle; Nicholas Chiorazzi; Peter M Lydyard
CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells.
British journal of haematology 2011;153(4):486-98.
2011: Nicholas Chiorazzi; Manlio Ferrarini
Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities.
Blood 2011;117(6):1781-91.
2011: Carlo Calissano; Steven Allen; Rajendra N Damle; Igor M Dozmorov; Claire Emson; Gregory Hayes; Marc K Hellerstein; Ivana Ivanovic; Matthew Kaufman; Jonathan E Kolitz; Wentian Li; Sonia Marsilio; Elizabeth J Murphy; Kanti R Rai; Sergio Roa; Matthew D Scharff; Cristina Sison; Joy (Xiao-Jie) Yan; Sophia Yancopoulos; Nicholas Chiorazzi
Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells.
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1374-82.
2011: Charles C Chu; Rajendra N Damle; Arjun Dhayalan; Sebastien Didier; Gia Fraher; Linda P Johnson; William J Kennedy; Prasad R K Koduru; Jonathan E Kolitz; Amanda R Magli; Piers E M Patten; Kanti R Rai; Saul Teichberg; Joy (Xiao-Jie) Yan; Lu Zhang; Briana M Agagnina; Steven Allen; Nicholas Chiorazzi
Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera.
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1338-48.
2011: Fabio Ghiotto; Paolo Marcatili; Fortunato Morabito; Claudya Tenca; Anna Tramontano; Joy (Xiao-Jie) Yan; Emilia Albesiano; Davide Bagnara; Silvia Bruno; Maria Grazia Calevo; Charles C Chu; Monica Colombo; Giovanna Cutrona; Franco Fais; Manlio Ferrarini; Nicholas Chiorazzi
Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells.
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1188-95.
2010: Federico Caligaris-Cappio; Nicholas Chiorazzi
Where is the biology of CLL leading us?
Seminars in cancer biology 2010;20(6):361-2.
2010: Hyunjoo Lee; Joshua S Trott; Shabirul Haque; Steven McCormick; Nicholas Chiorazzi; Patricia Mongini
A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5300-14.
2010: William G Wierda; Nicholas Chiorazzi; Claire Dearden; Jennifer R Brown; Emili Montserrat; Elizabeth Shpall; Stephan Stilgenbauer; Sabeeha Muneer; Michael Grever
Chronic lymphocytic leukemia: new concepts for future therapy.
Clinical lymphoma, myeloma & leukemia 2010;10(5):369-78.
2010: Gregory M Hayes; Robert Busch; Jason Voogt; Iche M Siah; Tracy A Gee; Marc K Hellerstein; Nicholas Chiorazzi; Kanti R Rai; Elizabeth J Murphy
Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: validation of a simplified method suitable for multi-center clinical studies.
Leukemia research 2010;34(6):809-15.
2010: Charles C Chu; Rosa Catera; Lu Zhang; Sebastien Didier; Briana M Agagnina; Rajendra N Damle; Matthew Kaufman; Jonathan E Kolitz; Steven Allen; Kanti Rai; Nicholas Chiorazzi
Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin.
Blood 2010;115(19):3907-15.
2010: Rajendra N Damle; Carlo Calissano; Nicholas Chiorazzi
Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells.
Best practice & research. Clinical haematology 2010;23(1):33-45.
2010: N Darzentas; A Hadzidimitriou; F Murray; K Hatzi; P Josefsson; N Laoutaris; C Moreno; A Anagnostopoulos; J Jurlander; A Tsaftaris; Nicholas Chiorazzi; C Belessi; P Ghia; R Rosenquist; F Davi; K Stamatopoulos
A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence.
Leukemia 2010;24(1):125-32.
2009: Carlo Calissano; Rajendra N Damle; Gregory Hayes; Elizabeth J Murphy; Marc K Hellerstein; Carol Moreno; Cristina Sison; Matthew Kaufman; Jonathan E Kolitz; Steven Allen; Kanti Rai; Nicholas Chiorazzi
In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia.
Blood 2009;114(23):4832-42.
2009: Till Seiler; Manuela Woelfle; Sophia Yancopoulos; Rosa Catera; Wentian Li; Katerina Hatzi; Carol Moreno; Marcela Torres; Santanu Paul; Hartmut Dohner; Stephan Stilgenbauer; Matthew Kaufman; Jonathan E Kolitz; Steven Allen; Kanti Rai; Charles C Chu; Nicholas Chiorazzi
Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells.
Blood 2009;114(17):3615-24.
2009: Nicholas Chiorazzi
The association for patient-oriented research.
Clinical and translational science 2009;2(3):175-7.
2009: Joy (Xiao-Jie) Yan; Mei Qi; Gloria Telusma; Sophia Yancopoulos; Michael P. Madaio; Minoru Satoh; Westley H Reeves; Saul Teichberg; Nina Kohn; Karen Auborn; Nicholas Chiorazzi
Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades.
Clinical immunology (Orlando, Fla.) 2009;131(3):481-94.
2009: Dina C Nacionales; Jason S Weinstein; Joy (Xiao-Jie) Yan; Emilia Albesiano; Pui Y Lee; Kindra M Kelly-Scumpia; Robert Lyons; Minoru Satoh; Nicholas Chiorazzi; Westley H Reeves
B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4226-36.
2009: Vladimir Grubor; Alexander Krasnitz; Jennifer E Troge; Jennifer L Meth; B Lakshmi; Jude T Kendall; Boris Yamrom; Garrick Alex; Deepa Pai; Nicholas Navin; Lisa A Hufnagel; Yoon-Ha Lee; Kerry Cook; Steven Allen; Kanti Rai; Rajendra N Damle; Carlo Calissano; Nicholas Chiorazzi; Michael Wigler; Diane Esposito
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA).
Blood 2009;113(6):1294-303.
2008: Charles C Chu; Rosa Catera; Katerina Hatzi; Joy (Xiao-Jie) Yan; Lu Zhang; Xiao Bo Wang; Henry M Fales; Steven Allen; Jonathan E Kolitz; Kanti Rai; Nicholas Chiorazzi
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA.
Blood 2008;112(13):5122-9.
2008: P Ghia; Nicholas Chiorazzi; K Stamatopoulos
Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation.
Journal of internal medicine 2008;264(6):549-62.
2008: Rosa Catera; Gregg J Silverman; Katerina Hatzi; Till Seiler; Sebastien Didier; Lu Zhang; Maxime Hervé; Eric Meffre; David G Oscier; Helen Vlassara; R Hal Scofield; Yifang Chen; Steven Allen; Jonathan Kolitz; Kanti Rai; Charles C Chu; Nicholas Chiorazzi
Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation.
Molecular medicine (Cambridge, Mass.) 2008;14(11-12):665-74.
2008: Jason S Weinstein; Dina C Nacionales; Pui Y Lee; Kindra M Kelly-Scumpia; Joy (Xiao-Jie) Yan; Philip O Scumpia; Dustin Vale-Cruz; Eric Sobel; Minoru Satoh; Nicholas Chiorazzi; Westley H Reeves
Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3259-67.
2008: Brian A McCarthy; Erin Boyle; Xue Ping Wang; Dorothy Guzowski; Santanu Paul; Rosa Catera; Joshua Trott; Joy (Xiao-Jie) Yan; Carlo M Croce; Rajendra N Damle; Sophia Yancopoulos; Bradley T Messmer; Martin Lesser; Steven Allen; Kanti Rai; Nicholas Chiorazzi
Surface expression of Bcl-2 in chronic lymphocytic leukemia and other B-cell leukemias and lymphomas without a breakpoint t(14;18).
Molecular medicine (Cambridge, Mass.) 2008;14(9-10):618-27.
2008: Fu Jun Li; Shouluan Ding; Jicun Pan; Mikhail A Shakhmatov; Elena Kashentseva; Jiongru Wu; Yufeng Li; Seng-Jaw Soong; Nicholas Chiorazzi; Randall S Davis
FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia.
Blood 2008;112(1):179-87.
2008: Giovanna Cutrona; Monica Colombo; Serena Matis; Marina Fabbi; Mauro Spriano; Vincenzo Callea; Ernesto Vigna; Massimo Gentile; Simonetta Zupo; Nicholas Chiorazzi; Fortunato Morabito; Manlio Ferrarini
Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells.
Haematologica 2008;93(3):413-22.
2007: Rajendra N Damle; Sonal Temburni; Carlo Calissano; Sophia Yancopoulos; Taraneh Banapour; Cristina P Sison; Steven Allen; Kanti Rai; Nicholas Chiorazzi
CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells.
Blood 2007;110(9):3352-9.
2007: Nicholas Chiorazzi
Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells.
Best practice & research. Clinical haematology 2007;20(3):399-413.
2007: Mariella Dono; Vito Lelio Burgio; Monica Colombo; Salvatore Sciacchitano; Daniele Reverberi; Vincenzo Tarantino; Giovanna Cutrona; Nicholas Chiorazzi; Manlio Ferrarini
CD5+ B cells with the features of subepithelial B cells found in human tonsils.
European journal of immunology 2007;37(8):2138-47.
2006: Fortunato Morabito; Rajendra N Damle; Silvia Deaglio; Michael Keating; Manlio Ferrarini; Nicholas Chiorazzi
The CD38 ectoenzyme family: advances in basic science and clinical practice.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):342-4.
2006: Fabio Ghiotto; Franco Fais; Emilia Albesiano; Cristina P Sison; Angelo Valetto; Gianluca Gaidano; Janine Reinhardt; Jonathan E Kolitz; Kanti Rai; Steven Allen; Manlio Ferrarini; Nicholas Chiorazzi
Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):300-8.
2006: Gloria Telusma; Sandip Datta; Ivan Mihajlov; Wenxue Ma; Jianhua Li; Huan Yang; Walter Newman; Bradley T Messmer; Boris Minev; Ingo G H Schmidt-Wolf; Kevin Tracey; Nicholas Chiorazzi; Davorka Messmer
Dendritic cell activating peptides induce distinct cytokine profiles.
International immunology 2006;18(11):1563-73.
2006: Joy (Xiao-Jie) Yan; Emilia Albesiano; nicola zanesi; Sophia Yancopoulos; Alan Sawyer; Egidio Romano; Aleksandar Petlichkovski; Dimitar G Efremov; Carlo M Croce; Nicholas Chiorazzi
B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11713-8.
2006: Elizabeth P Ryan; Stephen J Pollock; Kuljeet Kaur; Raymond E Felgar; Steven H Bernstein; Nicholas Chiorazzi; Richard P Phipps
Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells.
Clinical immunology (Orlando, Fla.) 2006;120(1):76-90.
2006: Mia Thorsélius; Alexander Kröber; Fiona Murray; Ulf Thunberg; Gerard Tobin; Andreas Bühler; Dirk Kienle; Emilia Albesiano; Rossana Maffei; Lan-Phuong Dao-Ung; James Wiley; Juhani Vilpo; Anna Laurell; Mats Merup; Göran Roos; Karin Karlsson; Nicholas Chiorazzi; Marasca Roberto; Hartmut Döhner; Stephan Stilgenbauer; Richard Rosenquist
Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status.
Blood 2006;107(7):2889-94.
2006: Giovanna Cutrona; Monica Colombo; Serena Matis; Daniele Reverberi; Mariella Dono; Vincenzo Tarantino; Nicholas Chiorazzi; Manlio Ferrarini
B lymphocytes in humans express ZAP-70 when activated in vivo.
European journal of immunology 2006;36(3):558-69.
2006: Nicholas Chiorazzi; Manlio Ferrarini
Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2006;():273-8, 512.
2006: Shunsei Hirohata; Yasushi Miura; Tetsuya Tomita; Hideki Yoshikawa; Takahiro Ochi; Nicholas Chiorazzi
Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis.
Arthritis research & therapy 2006;8(2):R54.
2005: Nicholas Chiorazzi; Katerina Hatzi; Emilia Albesiano
B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes with receptors that vary in specificity for (auto)antigens.
Annals of the New York Academy of Sciences 2005;1062():1-12.
2005: Dorothy Guzowski; Alamelu Chandrasekaran; Craig Gawel; Jacqueline Palma; Jonathan Koenig; Xue Ping Wang; Michael Dosik; Mark H Kaplan; Charles C Chu; Sangeeta S Chavan; Richard Furie; Emilia Albesiano; Nicholas Chiorazzi; Leslie Goodwin
Analysis of single nucleotide polymorphisms in the promoter region of interleukin-10 by denaturing high-performance liquid chromatography.
Journal of biomolecular techniques : JBT 2005;16(2):154-66.
2005: Maxime Hervé; Kai Xu; Yen-Shing Ng; Hedda Wardemann; Emilia Albesiano; Bradley T Messmer; Nicholas Chiorazzi; Eric Meffre
Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.
The Journal of clinical investigation 2005;115(6):1636-43.
2005: Bradley T Messmer; Davorka Messmer; Steven Allen; Jonathan E Kolitz; Prasad Kudalkar; Denise Cesar; Elizabeth J Murphy; Prasad R K Koduru; Manlio Ferrarini; Simona Zupo; Giovanna Cutrona; Rajendra N Damle; Tarun Wasil; Kanti Rai; Marc K Hellerstein; Nicholas Chiorazzi
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells.
The Journal of clinical investigation 2005;115(3):755-64.
2005: Nicholas Chiorazzi; Kanti Rai; Manlio Ferrarini
Chronic lymphocytic leukemia.
The New England journal of medicine 2005;352(8):804-15.
2005: Nicholas Chiorazzi; Steven Allen; Manlio Ferrarini
Clinical and laboratory parameters that define clinically relevant B-CLL subgroups.
Current topics in microbiology and immunology 2005;294():109-33.
2004: Bradley T Messmer; Emilia Albesiano; Dimitar G Efremov; Fabio Ghiotto; Steven Allen; Jonathan E Kolitz; Robin Foa; Rajendra N Damle; Franco Fais; Davorka Messmer; Kanti Rai; Manlio Ferrarini; Nicholas Chiorazzi
Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia.
The Journal of experimental medicine 2004;200(4):519-25.
2004: Davorka Messmer; Gloria Telusma; Tarun Wasil; Bradley T Messmer; Steven Allen; Kanti Rai; Nicholas Chiorazzi
Dendritic cells from chronic lymphocytic leukemia patients are normal regardless of Ig V gene mutation status.
Molecular medicine (Cambridge, Mass.) 2004;10(7-12):96-103.
2004: Manlio Ferrarini; Nicholas Chiorazzi
Recent advances in the molecular biology and immunobiology of chronic lymphocytic leukemia.
Seminars in hematology 2004;41(3):207-23.
2004: Davorka Messmer; Huan Yang; Gloria Telusma; Faye Knoll; Jianhua Li; Bradley T Messmer; Kevin Tracey; Nicholas Chiorazzi
High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):307-13.
2004: Bradley T Messmer; Emilia Albesiano; Davorka Messmer; Nicholas Chiorazzi
The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process.
Blood 2004;103(9):3490-5.
2004: Fabio Ghiotto; Franco Fais; Angelo Valetto; Emilia Albesiano; Shiori Hashimoto; Mariella Dono; Hideyuki Ikematsu; Steven Allen; Jonathan E Kolitz; Kanti Rai; Marco Nardini; Anna Tramontano; Manlio Ferrarini; Nicholas Chiorazzi
Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia.
The Journal of clinical investigation 2004;113(7):1008-16.
2004: Rajendra N Damle; Franak M Batliwalla; Fabio Ghiotto; Angelo Valetto; Emilia Albesiano; Cristina P Sison; Steven Allen; Jonathan E Kolitz; Vincent P Vinciguerra; Prasad Kudalkar; Tarun Wasil; Kanti Rai; Manlio Ferrarini; Peter K Gregersen; Nicholas Chiorazzi
Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations.
Blood 2004;103(2):375-82.
2003: Monica Colombo; Mariella Dono; Paola Gazzola; Nicholas Chiorazzi; Gianluigi Mancardi; Manlio Ferrarini
Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients.
European journal of immunology 2003;33(12):3433-8.
2003: Karen Auborn; Mei Qi; Joy (Xiao-Jie) Yan; Saul Teichberg; DaZhi Chen; Michael P. Madaio; Nicholas Chiorazzi
Lifespan is prolonged in autoimmune-prone (NZB/NZW) F1 mice fed a diet supplemented with indole-3-carbinol.
The Journal of nutrition 2003;133(11):3610-3.
2003: Emilia Albesiano; Bradley T Messmer; Rajendra N Damle; Steven Allen; Kanti Rai; Nicholas Chiorazzi
Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone.
Blood 2003;102(9):3333-9.
2003: Yasushi Miura; Charles C Chu; David M Dines; Stanley E Asnis; Richard Furie; Nicholas Chiorazzi
Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion.
Molecular medicine (Cambridge, Mass.) 2003;9(5-8):166-74.
2003: Juergen Foell; Simona Strahotin; Shawn P O'Neil; Megan McCausland; Carolyn Suwyn; Michael Haber; Praveen N Chander; Abhijit S Bapat; Joy (Xiao-Jie) Yan; Nicholas Chiorazzi; Michael K Hoffmann; Robert S Mittler
CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice.
The Journal of clinical investigation 2003;111(10):1505-18.
2003: Kanti Rai; Nicholas Chiorazzi
Determining the clinical course and outcome in chronic lymphocytic leukemia.
The New England journal of medicine 2003;348(18):1797-9.
2003: Mariella Dono; Simona Zupo; Monica Colombo; Rosanna Massara; Gianluca Gaidano; Giuseppe Taborelli; Paola Ceppa; Vito Lelio Burgio; Nicholas Chiorazzi; Manlio Ferrarini
The human marginal zone B cell.
Annals of the New York Academy of Sciences 2003;987():117-24.
2003: Davorka Messmer; Bradley T Messmer; Nicholas Chiorazzi
The global transcriptional maturation program and stimuli-specific gene expression profiles of human myeloid dendritic cells.
International immunology 2003;15(4):491-503.
2003: Michael J Keating; Nicholas Chiorazzi; Bradley T Messmer; Rajendra N Damle; Steven Allen; Kanti Rai; Manlio Ferrarini; Thomas Kipps
Biology and treatment of chronic lymphocytic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():153-75.
2003: Nicholas Chiorazzi; Manlio Ferrarini
B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor.
Annual review of immunology 2003;21():841-94.
2002: Julia Kurth; Andreas Perniok; Roland Schmitz; Christof Iking-Konert; Nicholas Chiorazzi; Keith M Thompson; Thomas Winkler; Klaus Rajewsky; Ralf Küppers
Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines.
European journal of immunology 2002;32(12):3785-92.
2002: Riikka Kokkola; Erik Sundberg; Ann-Kristin Ulfgren; Karin Palmblad; Jianhua Li; Hong Wang; Luis Ulloa; Huan Yang; Joy (Xiao-Jie) Yan; Richard Furie; Nicholas Chiorazzi; Kevin Tracey; Ulf Andersson; Helena Erlandsson Harris
High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis.
Arthritis and rheumatism 2002;46(10):2598-603.
2002: Carmela Gurrieri; Peter McGuire; Hong Zan; Joy (Xiao-Jie) Yan; Andrea Cerutti; Emilia Albesiano; Steven Allen; Vincent P Vinciguerra; Kanti Rai; Manlio Ferrarini; Paolo Casali; Nicholas Chiorazzi
Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.
The Journal of experimental medicine 2002;196(5):629-39.
2002: Rajendra N Damle; Fabio Ghiotto; Angelo Valetto; Emilia Albesiano; Franco Fais; Joy (Xiao-Jie) Yan; Cristina P Sison; Steven Allen; Jonathan E Kolitz; Philip Schulman; Vincent P Vinciguerra; Petra Budde; Jurgen Frey; Kanti Rai; Manlio Ferrarini; Nicholas Chiorazzi
B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes.
Blood 2002;99(11):4087-93.
2002: Jidong Shan; Liming Yuan; Qianxun Xiao; Nicholas Chiorazzi; Daniel R Budman; Saul Teichberg; Hao-Peng X. Duffy
TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells.
Cancer research 2002;62(1):290-4.
2001: Andreas Rosenwald; A A Alizadeh; George F Widhopf; R Simon; R Eric Davis; X Yu; L Yang; Oxana Pickeral; Laura Rassenti; J Powell; D Botstein; J C Byrd; M R Grever; B D Cheson; Nicholas Chiorazzi; Wyndham H Wilson; Thomas Kipps; P O Brown; Louis M Staudt
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia.
The Journal of experimental medicine 2001;194(11):1639-47.
2001: M Maruno; Kazumichi Furuyama; Reiko Akagi; Y Horie; K Meguro; L Garbaczewski; Nicholas Chiorazzi; MO Doss; A Hassoun; R Mercelis; L Verstraeten; P Harper; Y Floderus; S Thunell; Shigeru Sassa
Highly heterogeneous nature of delta-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria.
Blood 2001;97(10):2972-8.
2001: Mariella Dono; Simona Zupo; Rosanna Massara; Silvano Ferrini; A Melagrana; Nicholas Chiorazzi; Manlio Ferrarini
In vitro stimulation of human tonsillar subepithelial B cells: requirement for interaction with activated T cells.
European journal of immunology 2001;31(3):752-6.
2001: Franak M Batliwalla; Rajendra N Damle; C Metz; Nicholas Chiorazzi; Peter K Gregersen
Simultaneous flow cytometric analysis of cell surface markers and telomere length: analysis of human tonsilar B cells.
Journal of immunological methods 2001;247(1-2):103-9.
2000: Franco Fais; Gilberto Fronza; silvio Roncella; Alberto Inga; Paola Campomenosi; Giovanna Cutrona; Annalisa Pezzolo; Franco Fedeli; Angelo Abbondandolo; Nicholas Chiorazzi; Vito Pistoia; Manlio Ferrarini
Analysis of stepwise genetic changes in an AIDS-related Burkitt's lymphoma.
International journal of cancer. Journal international du cancer 2000;88(5):744-50.
2000: K Itoh; Eric Meffre; Emilia Albesiano; A Farber; D Dines; P Stein; Stanley E Asnis; Richard Furie; RI Jain; Nicholas Chiorazzi
Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes.
The Journal of experimental medicine 2000;192(8):1151-64.
2000: Mariella Dono; Simona Zupo; N Leanza; G Melioli; M Fogli; A Melagrana; Nicholas Chiorazzi; Manlio Ferrarini
Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5596-604.
2000: Daniela Capello; Franco Fais; Daniela Vivenza; Giuseppe Migliaretti; Nicholas Chiorazzi; Gianluca Gaidano; Manlio Ferrarini
Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes.
Leukemia 2000;14(5):811-5.
2000: Monica Colombo; Mariella Dono; Paola Gazzola; silvio Roncella; Angelo Valetto; Nicholas Chiorazzi; Giovanni Luigi Mancardi; Manlio Ferrarini
Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2782-9.
2000: K Itoh; V Patki; Richard Furie; E K Chartash; RI Jain; L Lane; Stanley E Asnis; Nicholas Chiorazzi
Clonal expansion is a characteristic feature of the B-cell repetoire of patients with rheumatoid arthritis.
Arthritis research 2000;2(1):50-8.
2000: Rajendra N Damle; Franco Fais; Fabio Ghiotto; Angelo Valetto; Emilia Albesiano; Tarun Wasil; Franak M Batliwalla; Steven Allen; Philip Schulman; Vincent P Vinciguerra; Kanti Rai; Peter K Gregersen; Manlio Ferrarini; Nicholas Chiorazzi
Chronic lymphocytic leukemia: a proliferation of B cells at two distinct stages of differentiation.
Current topics in microbiology and immunology 2000;252():285-92.
1999: Otto Pritsch; Xavier Troussard; Christian Magnac; Francesca Mauro; Frédéric Davi; Béatrice Payelle-Brogard; Gérard Dumas; Marc Pulik; F Clerget; F Mandelli; Nicholas Chiorazzi; Harry Schroeder; Michel Leporrier; Guillaume Dighiero
VH gene usage by family members affected with chronic lymphocytic leukaemia.
British journal of haematology 1999;107(3):616-24.
1999: Rajendra N Damle; Tarun Wasil; Franco Fais; Fabio Ghiotto; Angelo Valetto; Steven Allen; A Buchbinder; Daniel R Budman; K Dittmar; Jonathan E Kolitz; Stuart M Lichtman; Philip Schulman; Vincent P Vinciguerra; Kanti Rai; Manlio Ferrarini; Nicholas Chiorazzi
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.
Blood 1999;94(6):1840-7.
1999: N Hirose; R Williams; A R Alberts; Richard Furie; E K Chartash; RI Jain; Cristina P Sison; Robert G Lahita; Joan T Merrill; Elena Cucurull; Azzudin E Gharavi; Lisa Sammaritano; Jane E Salmon; S Hashimoto; T Sawada; Charles C Chu; Peter K Gregersen; Nicholas Chiorazzi
A role for the polymorphism at position 247 of the beta2-glycoprotein I gene in the generation of anti-beta2-glycoprotein I antibodies in the antiphospholipid syndrome.
Arthritis and rheumatism 1999;42(8):1655-61.
1999: Franco Fais; Gianluca Gaidano; Daniela Capello; A Gloghini; Fabio Ghiotto; silvio Roncella; A Carbone; Nicholas Chiorazzi; Manlio Ferrarini
Immunoglobulin V region gene use and structure suggest antigen selection in AIDS-related primary effusion lymphomas.
Leukemia 1999;13(7):1093-9.
1999: Luca Musante; Massimo Ulivi; Giovanna Cutrona; Nicholas Chiorazzi; silvio Roncella; Giovanni Candiano; Manlio Ferrarini
Identification of HSP-60 as the specific antigen of IgM produced by BRG-lymphoma cells.
Electrophoresis 1999;20(4-5):1092-7.
1999: BT Messmer; JJ Sullivan; Nicholas Chiorazzi; TC Rodman; David S Thaler
Two human neonatal IgM antibodies encoded by different variable-region genes bind the same linear peptide: evidence for a stereotyped repertoire of epitope recognition.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2184-92.
1998: Franco Fais; Fabio Ghiotto; S Hashimoto; B Sellars; Angelo Valetto; Steven Allen; Philip Schulman; Vincent P Vinciguerra; Kanti Rai; Laura Rassenti; Thomas Kipps; Guillaume Dighiero; Harry Schroeder; Manlio Ferrarini; Nicholas Chiorazzi
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.
The Journal of clinical investigation 1998;102(8):1515-25.
1998: B Schiller; Nicholas Chiorazzi; B F Farber
Methicillin-resistant Staphylococcal enterocolitis.
The American journal of medicine 1998;105(2):164-6.
1998: EW Schettino; Andrea Cerutti; Nicholas Chiorazzi; Paolo Casali
Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):820-30.
1997: Paola Campomenosi; Gilberto Fronza; Laura Ottaggio; silvio Roncella; Alberto Inga; Massimo Bogliolo; Paola Monti; P Assereto; Francesca Moro; Giovanna Cutrona; S Bozzo; Nicholas Chiorazzi; Angelo Abbondandolo; Manlio Ferrarini
Heterogeneous p53 mutations in a Burkitt lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements.
International journal of cancer. Journal international du cancer 1997;73(6):816-21.
1997: TC Rodman; R Winston; JJ Sullivan; Joy (Xiao-Jie) Yan; Nicholas Chiorazzi
An innate natural antibody is reactive with a cryptic sequence of lactoferrin exposed on sperm head surface.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1997;216(3):404-9.
1997: V Patki; J Monteiro; P K Gregersen; Nicholas Chiorazzi
Evidence for B cell oligoclonality in the blood and joints of patients with rheumatoid arthritis.
Annals of the New York Academy of Sciences 1997;815():472-4.
1997: K J Campagna; Nicholas Chiorazzi; MD Chang
The accessory cell function of B-CLL B cells.
Annals of the New York Academy of Sciences 1997;815():427-31.
1997: Mariella Dono; Simona Zupo; Vito Lelio Burgio; A Augliera; Carlo Tacchetti; Anna Favre; Carlo E Grossi; Nicholas Chiorazzi; Manlio Ferrarini
Phenotypic and functional characterization of human tonsillar subepithelial (SE) B cells.
Annals of the New York Academy of Sciences 1997;815():171-81.
1997: D Serrano; J Monteiro; Steven Allen; Jonathan E Kolitz; Philip Schulman; Stuart M Lichtman; A Buchbinder; Vincent P Vinciguerra; Nicholas Chiorazzi; Peter K Gregersen
Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1482-9.
1997: Mariella Dono; Simona Zupo; Carlo E Grossi; Nicholas Chiorazzi; Manlio Ferrarini
Subepithelial B cells of the human tonsil.
Chemical immunology 1997;67():58-69.
1996: Nicholas Chiorazzi
Human B cell subsets in health and disease: phenotypic, functional, and genetic analyses.
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 1996;19(6):540.
1996: Guillaume Dighiero; T Kipps; Harry Schroeder; Nicholas Chiorazzi; F Stevenson; Leslie E Silberstein; F Caligaris-Cappio; M Ferrarini
What is the CLL B-lymphocyte?
Leukemia & lymphoma 1996;22 Suppl 2():13-39.
1996: Franco Fais; B Sellars; Fabio Ghiotto; Joy (Xiao-Jie) Yan; Mariella Dono; Steven Allen; Daniel R Budman; K Dittmar; Jonathan E Kolitz; Stuart M Lichtman; Philip Schulman; M Schuster; Vincent P Vinciguerra; Kanti Rai; F K Stevenson; Peter K Gregersen; Manlio Ferrarini; Nicholas Chiorazzi
Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.
The Journal of clinical investigation 1996;98(7):1659-66.
1996: Mariella Dono; Simona Zupo; A Augliera; Vito Lelio Burgio; R Massara; A Melagrana; mauro costa; Carlo E Grossi; Nicholas Chiorazzi; Manlio Ferrarini
Subepithelial B cells in the human palatine tonsil. II. Functional characterization.
European journal of immunology 1996;26(9):2043-9.
1996: Mariella Dono; Vito Lelio Burgio; C Tacchetti; A Favre; A Augliera; Simona Zupo; G Taborelli; Nicholas Chiorazzi; Carlo E Grossi; Manlio Ferrarini
Subepithelial B cells in the human palatine tonsil. I. Morphologic, cytochemical and phenotypic characterization.
European journal of immunology 1996;26(9):2035-42.
1996: silvio Roncella; Giovanna Cutrona; A Favre; Massimo Ulivi; Franco Fais; A Signorini; Carlo E Grossi; Nicholas Chiorazzi; Manlio Ferrarini
Apoptosis of Burkitt's lymphoma cells induced by specific interaction of surface IgM with a self-antigen: implications for lymphomagenesis in acquired immunodeficiency syndrome.
Blood 1996;88(2):599-608.
1996: Dimitar G Efremov; Martin Ivanovski; N Siljanovski; Gabriele Pozzato; L Cevreska; Franco Fais; Nicholas Chiorazzi; F D Batista; Oscar R. Burrone
Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia.
Blood 1996;87(9):3869-76.
1996: Mariella Dono; S Hashimoto; Franco Fais; V Trejo; Steven Allen; Stuart M Lichtman; Philip Schulman; Vincent P Vinciguerra; B Sellars; Peter K Gregersen; Manlio Ferrarini; Nicholas Chiorazzi
Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification.
Blood 1996;87(4):1586-94.
1995: S Hashimoto; Mariella Dono; Vincent P Vinciguerra; J Silver; Nicholas Chiorazzi
Clonal heterogeneity in membrane expression of CD5 in a patient with chronic lymphocytic leukemia.
Annals of the New York Academy of Sciences 1995;764():482-4.
1995: Mariella Dono; S Hashimoto; Manlio Ferrarini; Nicholas Chiorazzi
In vivo isotype class switching in CD5+ chronic lymphocytic leukemia B cells.
Annals of the New York Academy of Sciences 1995;764():478-81.
1995: S Hashimoto; Nicholas Chiorazzi; Peter K Gregersen
Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.
Molecular immunology 1995;32(9):651-9.
1995: S Hashimoto; Mariella Dono; M Wakai; Steven Allen; Stuart M Lichtman; Philip Schulman; Vincent P Vinciguerra; Manlio Ferrarini; Jack Silver; Nicholas Chiorazzi
Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.
The Journal of experimental medicine 1995;181(4):1507-17.
1995: Florencia Bullrich; TK MacLachlan; Nianli Sang; Teresa Druck; Maria L Veronese; Steven Allen; Nicholas Chiorazzi; Andrew Koff; K Heubner; Carlo M Croce
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.
Cancer research 1995;55(6):1199-205.
1995: Patricia Mongini; C A Blessinger; Nicholas Chiorazzi; N Rajaram; SM Rudich
A monovalent C mu 4-specific ligand enhances the activation of human B cells by membrane IgM cross-linking ligands.
International immunology 1995;7(2):317-30.
1995: R I Jain; Franco Fais; S Kaplan; B Sellars; R Brooks; E Chartash; Richard Furie; S Hashimoto; Nicholas Chiorazzi
IgH and L chain variable region gene sequence analyses of twelve synovial tissue-derived B cell lines producing IgA, IgG, and IgM rheumatoid factors structure/function comparisons of antigenic specificity, V gene sequence, and Ig isotype.
Autoimmunity 1995;22(4):229-43.
1994: R Jain; silvio Roncella; S Hashimoto; A Carbone; P Francia di Celle; Robin Foa; Manlio Ferrarini; Nicholas Chiorazzi
A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):45-52.
1994: Simona Zupo; Mariella Dono; R Massara; G Taborelli; Nicholas Chiorazzi; Manlio Ferrarini
Expression of CD5 and CD38 by human CD5- B cells: requirement for special stimuli.
European journal of immunology 1994;24(6):1426-33.
1994: S Hashimoto; Harvey W Mohrenweiser; Peter K Gregersen; Nicholas Chiorazzi
Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene.
Immunogenetics 1994;40(4):287-95.
1994: S Hashimoto; Nicholas Chiorazzi; Peter K Gregersen
The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.
Immunogenetics 1994;40(2):145-9.
1993: Prasad R K Koduru; Stuart M Lichtman; TF Smilari; Tsieh Sun; J C Goh; L Karp; W Hall; S Hashimoto; Nicholas Chiorazzi; J D Broome
Serial phenotypic, cytogenetic and molecular genetic studies in Richter's syndrome: demonstration of lymphoma development from the chronic lymphocytic leukaemia cells.
British journal of haematology 1993;85(3):613-6.
1993: Mariella Dono; Simona Zupo; R Masante; G Taborelli; Nicholas Chiorazzi; Manlio Ferrarini
Identification of two distinct CD5- B cell subsets from human tonsils with different responses to CD40 monoclonal antibody.
European journal of immunology 1993;23(4):873-81.
1993: M Wakai; P Pasley; Z M Sthoeger; D N Posnett; R Brooks; S Hashimoto; Nicholas Chiorazzi
Anti-CD23 monoclonal antibodies: comparisons of epitope specificities and modulating capacities for IgE binding and production.
Hybridoma 1993;12(1):25-43.
1993: S Hashimoto; Peter K Gregersen; Nicholas Chiorazzi
The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):491-8.
1993: S Kaplan; K Hyman; R Brooks; M Wakai; S Hashimoto; Richard Furie; Nicholas Chiorazzi
Monoclonal IgM, IgG, and IgA human rheumatoid factors produced by synovial tissue-derived, EBV-transformed B cell lines.
Clinical immunology and immunopathology 1993;66(1):18-25.
1992: S Hashimoto; M Wakai; Jack Silver; Nicholas Chiorazzi
Biased usage of variable and constant-region Ig genes by IgG+, CD5+ human leukemic B cells.
Annals of the New York Academy of Sciences 1992;651():477-9.
1992: Nicholas Chiorazzi
Generation of stable human autoantibody-secreting B cell hybridomas.
Molecular biology reports 1992;16(2):65-73.
1991: Simona Zupo; Mariella Dono; Livio Azzoni; Nicholas Chiorazzi; Manlio Ferrarini
Evidence for differential responsiveness of human CD5+ and CD5- B cell subsets to T cell-independent mitogens.
European journal of immunology 1991;21(2):351-9.
1990: R Mayer; T Logtenberg; J Strauchen; A Dimitriu-Bona; Lloyd Mayer; S Mechanic; Nicholas Chiorazzi; L Borche; Guillaume Dighiero; A Mannheimer-Lory
CD5 and immunoglobulin V gene expression in B-cell lymphomas and chronic lymphocytic leukemia.
Blood 1990;75(7):1518-24.
1990: Leonard B Saltz; D M Knowles; S Mechanic; P Pasley; R Brooks; M Wakai; Nicholas Chiorazzi
Augmentation by cytochalasin B of antigen receptor-mediated activation of normal and malignant human B lymphocytes.
Scandinavian journal of immunology 1990;31(1):109-19.
1989: C G Baum; Nicholas Chiorazzi; S Frankel; G M Shepherd
Conversion of systemic lupus erythematosus to common variable hypogammaglobulinemia.
The American journal of medicine 1989;87(4):449-56.
1989: D M Novick; M Ochshorn; Violette Ghali; T S Croxson; W D Mercer; Nicholas Chiorazzi; Mary Jeanne Kreek
Natural killer cell activity and lymphocyte subsets in parenteral heroin abusers and long-term methadone maintenance patients.
The Journal of pharmacology and experimental therapeutics 1989;250(2):606-10.
1989: Z M Sthoeger; M Wakai; D B Tse; Vincent P Vinciguerra; Steven Allen; Daniel R Budman; Stuart M Lichtman; Philip Schulman; L R Weiselberg; Nicholas Chiorazzi
Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.
The Journal of experimental medicine 1989;169(1):255-68.
1988: William Stohl; D N Posnett; Nicholas Chiorazzi
Differential immunomodulation by anti-CD2 monoclonal antibodies of anti-CD3-induced T cell activation: dependence upon the individual anti-CD3 monoclonal antibody used for activation.
Cellular immunology 1988;116(1):73-85.
1988: David N Posnett; A Gottlieb; J B Bussel; S M Friedman; Nicholas Chiorazzi; Y Li; P Szabo; N R Farid; M A Robinson
T cell antigen receptors in autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):1963-9.
1988: Z M Sthoeger; Nicholas Chiorazzi; R G Lahita
Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):91-8.
1988: R D Bigler; Yuri Bushkin; Nicholas Chiorazzi
S152 (CD27). A modulating disulfide-linked T cell activation antigen.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):21-8.
1988: L T May; J Ghrayeb; U Santhanam; S B Tatter; Z Sthoeger; D C Helfgott; Nicholas Chiorazzi; G Grieninger; Pravin B Sehgal
Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes.
The Journal of biological chemistry 1988;263(16):7760-6.
1987: Nicholas Chiorazzi; W H Reeves
Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody.
The Journal of experimental medicine 1987;165(4):1172-87.
1987: William Stohl; D N Posnett; Nicholas Chiorazzi
Induction of T cell-dependent B cell differentiation by anti-CD3 monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1667-73.
1987: Nicholas Chiorazzi
Stimulation of lymphocytes with antibodies to surface membrane-bound antigen receptors.
Methods in enzymology 1987;150():92-104.
1986: W H Reeves; Nicholas Chiorazzi
Interaction between anti-DNA and anti-DNA-binding protein autoantibodies in cryoglobulins from sera of patients with systemic lupus erythematosus.
The Journal of experimental medicine 1986;164(4):1029-42.
1986: W H Reeves; D E Fisher; R Wisniewolski; A B Gottlieb; Nicholas Chiorazzi
Psoriasis and Raynaud's phenomenon associated with autoantibodies to U1 and U2 small nuclear ribonucleoproteins.
The New England journal of medicine 1986;315(2):105-11.
1986: L Mayer; SP Kwan; C Thompson; H S Ko; Nicholas Chiorazzi; Thomas Waldmann; F Rosen
Evidence for a defect in "switch" T cells in patients with immunodeficiency and hyperimmunoglobulinemia M.
The New England journal of medicine 1986;314(7):409-13.
1985: D E Fisher; W H Reeves; R Wisniewolski; R G Lahita; Nicholas Chiorazzi
Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus.
Arthritis and rheumatism 1985;28(12):1348-55.
1985: TC Rodman; J Laurence; F H Pruslin; Nicholas Chiorazzi; R Winston
Naturally occurring antibodies reactive with sperm proteins: apparent deficiency in AIDS sera.
Science (New York, N.Y.) 1985;228(4704):1211-5.
1985: R Schwarting; K Welte; Nicholas Chiorazzi; P Ralph; C L Lane; C Long; C Y Wang
Biochemical characterization and purification of human B cell stimulatory factor (BSF).
European journal of immunology 1985;15(6):632-7.
1985: R D Bigler; David N Posnett; Nicholas Chiorazzi
Stimulation of a subset of normal resting T lymphocytes by a monoclonal antibody to a crossreactive determinant of the human T cell antigen receptor.
The Journal of experimental medicine 1985;161(6):1450-63.
1984: R Schwarting; C Lane; E A Kan; Nicholas Chiorazzi; C Y Wang
Human B-cell-stimulatory-factor production by both T4+ and T8+ lymphocytes.
Cellular immunology 1984;88(1):41-8.
1984: D N Posnett; C Y Wang; Nicholas Chiorazzi; Mary Crow; H G Kunkel
An antigen characteristic of hairy cell leukemia cells is expressed on certain activated B cells.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(3):1635-40.
1984: David N Posnett; R D Bigler; Yuri Bushkin; D E Fisher; C Y Wang; L F Mayer; Nicholas Chiorazzi; H G Kunkel
T cell antiidiotypic antibodies reveal differences between two human leukemias.
The Journal of experimental medicine 1984;160(2):494-505.
1984: C Y Wang; W Azzo; Ayad Al-Katib; Nicholas Chiorazzi; D M Knowles
Preparation and characterization of monoclonal antibodies recognizing three distinct differentiation antigens (BL1, BL2, BL3) on human B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(2):684-91.
1983: R G Lahita; Nicholas Chiorazzi; Allan Gibofsky; R J Winchester; H G Kunkel
Familial systemic lupus erythematosus in males.
Arthritis and rheumatism 1983;26(1):39-44.
1982: Nicholas Chiorazzi; R L Wasserman; H G Kunkel
Use of Epstein-Barr virus-transformed B cell lines for the generation of immunoglobulin-producing human B cell hybridomas.
The Journal of experimental medicine 1982;156(3):930-5.
1982: D N Posnett; Nicholas Chiorazzi; H G Kunkel
Monoclonal antibodies with specificity for hairy cell leukemia cells.
The Journal of clinical investigation 1982;70(2):254-61.
1982: J N Ambinder; Nicholas Chiorazzi; Allan Gibofsky; M Fotino; H G Kunkel
Special characteristics of cellular immune function in normal individuals of the HLA-DR3 type.
Clinical immunology and immunopathology 1982;23(2):269-74.
1980: G Montazeri; Nicholas Chiorazzi; S M Fu; H G Kunkel
Regulatory role of circulating monocytes in the differentiative and proliferative responses of human B lymphocytes.
Clinical immunology and immunopathology 1980;16(1):1-10.
1980: D T Yu; Nicholas Chiorazzi; H G Kunkel
Helper factors derived from autologous mixed lymphocyte cultures.
Cellular immunology 1980;50(2):305-13.
1980: Nicholas Chiorazzi; S M Fu; H G Kunkel
Stimulation of human B lymphocytes by antibodies to IgM and IgG: functional evidence for the expression of IgG on B-lymphocyte surface membranes.
Clinical immunology and immunopathology 1980;15(3):301-13.
1979: Nicholas Chiorazzi; S M Fu; H G Kunkel
Induction of polyclonal antibody synthesis by human allogeneic and autologous helper factors.
The Journal of experimental medicine 1979;149(6):1543-8.
1979: A B Gottlieb; R G Lahita; Nicholas Chiorazzi; H G Kunkel
Immune function in systemic lupus erythematosus. Impairment of in vitro T-cell proliferation and in vivo antibody response to exogenous antigen.
The Journal of clinical investigation 1979;63(5):885-92.
1979: Nicholas Chiorazzi; A S Tung; D H Katz
Hapten-specific IgE antibody responses in mice. IX. Suppression of IgE antibody production by passive transfer of T cells from adjuvant-primed syngeneic mice.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(4):1495-501.
1979: Nicholas Chiorazzi; S M Fu; G Montazeri; H G Kunkel; Kanti Rai; T Gee
T cell helper defect in patients with chronic lymphocytic leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(3):1087-90.
1979: T P King; L Kochoumian; Nicholas Chiorazzi
Immunological properties of conjugates of ragweed pollen antigen E with methoxypolyethylene glycol or a copolymer of D-glutamic acid and D-lysine.
The Journal of experimental medicine 1979;149(2):424-35.
1979: S M Fu; Nicholas Chiorazzi; H G Kunkel
Differentiation capacity and other properties of the leukemic cells of chronic lymphocytic leukemia.
Immunological reviews 1979;48():23-44.
1979: Nicholas Chiorazzi; S M Fu; H G Kunkel
Induction of human antibody responses in vitro with emphasis on allogeneic helper factors.
Immunological reviews 1979;45():219-41.
1978: S M Fu; Nicholas Chiorazzi; H G Kunkel; J P Halper; S R Harris
Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes.
The Journal of experimental medicine 1978;148(6):1570-8.
1978: S M Fu; Nicholas Chiorazzi; C Y Wang; G Montrazeri; H G Kunkel; H S Ko; A B Gottlieb
Ia-bearing T lymphocytes in man. Their identification and role in the generation of allogeneic helper activity.
The Journal of experimental medicine 1978;148(5):1423-8.
1978: A S Tung; Nicholas Chiorazzi; D H Katz
Regulation of IgE antibody production by serum molecules. I. Serum from complete Freund's adjuvant-immune donors suppresses irradiation-enhanced IgE production in low responder mouse strains.
Journal of immunology (Baltimore, Md. : 1950) 1978;120(6):2050-9.
1977: Nicholas Chiorazzi; A S Tung; N Eshhar; D H Katz
Hapten-specific IgE antibody responses in mice. VIII. A possible new mechanism by which anti-lymphocyte serum enhances IgE antibody synthesis in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1977;119(2):685-93.
1977: Nicholas Chiorazzi; A S Tung; D H Katz
Induction of a ragweed-specific allergic state in Ir-gene-restricted nonresponder mice.
The Journal of experimental medicine 1977;146(1):302-7.
1977: Nicholas Chiorazzi; David A Fox; D H Katz
Hapten-specific IgE antibody responses in mice. VII. Conversion of IgE "non-responder" strains to IgE "responders" by elimination of suppressor T cell activity.
Journal of immunology (Baltimore, Md. : 1950) 1977;118(1):48-54.
1976: Nicholas Chiorazzi; David A Fox; D H Katz
Hapten-specific IgE antibody responses in mice. VI. Selective enhancement of IgE antibody production by low doses of X-irradiation and by cyclophosphamide.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(5 Pt 1):1629-37.
1976: David A Fox; Nicholas Chiorazzi; D H Katz
Hapten specific IgE antibody responses in mice. V. Differential resistance of IgE and IgG B lymphocytes to X-irradiation.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(5 Pt 1):1622-8.
1976: D H Katz; Nicholas Chiorazzi; J McDonald; L R Katz
Cell interactions between histoincompatible T an B lymphocytes. IX. The failure of histoincompatible cells is not due to suppression and cannot be circumvented by carrier-priming T cells with allogeneic macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(5 Pt.2):1853-9.
1976: Nicholas Chiorazzi; Z Eshhar; D H Katz
Induction if immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(6):2091-5.
1974: Nicholas Chiorazzi; L U Mailloux; M Susin; E P Bassett; R Waldbaum
Recurrent hematuria. Occurrence in a white woman with sickle cell trait.
JAMA : the journal of the American Medical Association 1974;230(4):582-4.
1974: Nicholas Chiorazzi; P G Hetzel; K P Adler; G I Wadler; H L Stein
Aortic dissection in a patient with chronic hemodialysis.
JAMA : the journal of the American Medical Association 1974;228(9):1146.
1974: Nicholas Chiorazzi; H S Weiss; D Margouleff; S Farber; S J Gulotta
Long-term pulmonary blood flow alterations following relief of partial bronchial obstruction.
The American journal of medicine 1974;56(4):559-64.
1973: K M Moser; M Guisan; E E Bartimmo; A M Longo; P G Harsanyi; Nicholas Chiorazzi
In vivo and post mortem dissolution rates of pulmonary emboli and venous thrombi in the dog.
Circulation 1973;48(1):170-8.