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Nicole Deglon

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Clévio Nóbrega; Isabel Onofre; David Albuquerque; Nicole Deglon; Hirokazu Hirai; Isabel Nascimento-Ferreira; Luis de Almeida
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
Aurélie Delzor; Noelle Dufour; Martine Guillermier; Philippe Hantraye; Diane Houitte; Fanny Petit; Gwennaelle Auregan; Emmanuel Brouillet; Nicole Deglon
Restricted transgene expression in the brain with cell-type specific neuronal promoters.
Ana T Simões; Nicole Deglon; Carlos Bandeira Duarte; Nélio Gonçalves; Arnulf Koeppen; Sebastian Kügler; Luis de Almeida
Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.

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All Publications

2013: Clévio Nóbrega; Isabel Onofre; David Albuquerque; Nicole Deglon; Hirokazu Hirai; Isabel Nascimento-Ferreira; Luis de Almeida
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
PloS one 2013;8(1):e52396.
2012: Aurélie Delzor; Noelle Dufour; Martine Guillermier; Philippe Hantraye; Diane Houitte; Fanny Petit; Gwennaelle Auregan; Emmanuel Brouillet; Nicole Deglon
Restricted transgene expression in the brain with cell-type specific neuronal promoters.
Human gene therapy methods 2012;23(4):242-54.
2012: Ana T Simões; Nicole Deglon; Carlos Bandeira Duarte; Nélio Gonçalves; Arnulf Koeppen; Sebastian Kügler; Luis de Almeida
Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.
Brain : a journal of neurology 2012;135(Pt 8):2428-39.
2011: Elodie Martin; Sandrine Betuing; Christiane Pagès; Karine Cambon; Gwenaelle Auregan; Nicole Deglon; Emmanuel Roze; Jocelyne Caboche
Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.
Human molecular genetics 2011;20(12):2422-34.
2011: Carole Escartin; Carole Malgorn; Gwennaelle Auregan; Ari E Berman; Pei-Chun Chen; Nicole Deglon; Jeffrey A Johnson; Sang Won Suh; Seok Joon Won; Raymond Swanson
Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(20):7392-401.
2011: Isabel Nascimento-Ferreira; Tiago Santos-Ferreira; Lígia Sousa-Ferreira; Gwennaëlle Auregan; Isabel Onofre; Sandro Alves; Noëlle Dufour; Veronica F Colomer Gould; Arnulf Koeppen; Nicole Deglon; Luis de Almeida
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Brain : a journal of neurology 2011;134(Pt 5):1400-15.
2010: Mathilde Faideau; Jinho Kim; Kerry Cormier; Richard Gilmore; Mackenzie Welch; Gwennaelle Auregan; Noelle Dufour; Martine Guillermier; Emmanuel Brouillet; Philippe Hantraye; Nicole Deglon; Robert J Ferrante; Gilles Bonvento
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.
Human molecular genetics 2010;19(15):3053-67.
2010: Sandro Alves; Isabel Nascimento-Ferreira; Noëlle Dufour; Raymonde Hassig; Gwennaëlle Auregan; Clévio Nóbrega; Emmanuel Brouillet; Philippe Hantraye; Maria C Pedroso De Lima; Nicole Deglon; Luis de Almeida
Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?
Human molecular genetics 2010;19(12):2380-94.
2010: Maria Damiano; Laurie Galvan; Nicole Deglon; Emmanuel Brouillet
Mitochondria in Huntington's disease.
Biochimica et biophysica acta 2010;1802(1):52-61.
2009: Nikita Rudinskiy; Yoshio A Kaneko; Ayshe Ana Beesen; Ozgun Gokce; Etienne Régulier; Nicole Deglon; Ruth Luthi-Carter
Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.
Journal of neurochemistry 2009;111(2):460-72.
2009: Angélique Colin; Mathilde Faideau; Noelle Dufour; Gwennaelle Auregan; Raymonde Hassig; THIBAULT ANDRIEU; Emmanuel Brouillet; Philippe Hantraye; Gilles Bonvento; Nicole Deglon
Engineered lentiviral vector targeting astrocytes in vivo.
Glia 2009;57(6):667-79.
2009: Carine Ciron; arnaud cressant; Françoise Roux; Sylvie Raoul; Yan Cherel; Philippe Hantraye; Nicole Deglon; Bertrand Schwartz; Martine Barkats; Jean Michel Heard; Marc Tardieu; Philippe Moullier; Marie-Anne Colle
Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution.
Human gene therapy 2009;20(4):350-60.
2009: Valérie Drouet; Valérie Perrin; Raymonde Hassig; Noëlle Dufour; Gwennaelle Auregan; Sandro Alves; Gilles Bonvento; Emmanuel Brouillet; Ruth Luthi-Carter; Philippe Hantraye; Nicole Deglon
Sustained effects of nonallele-specific Huntingtin silencing.
Annals of neurology 2009;65(3):276-85.
2009: Ludovic Leriche; Tomas Björklund; Nathalie Breysse; Laurent Besret; Marie-Claude Grégoire; Thomas Carlsson; Frédéric Dollé; Ronald J Mandel; Nicole Deglon; Philippe Hantraye; Deniz Kirik
Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(5):1544-53.
2009: Elsa Diguet; Fanny Petit; Carole Escartin; Karine Cambon; Nicolas Bizat; Noëlle Dufour; Philippe Hantraye; Nicole Deglon; Emmanuel Brouillet
Normal aging modulates the neurotoxicity of mutant huntingtin.
PloS one 2009;4(2):e4637.
2009: V Perrin; N Dufour; C Raoul; R Hassig; E Brouillet; P Aebischer; R Luthi-Carter; Nicole Deglon
Implication of the JNK pathway in a rat model of Huntington's disease.
Experimental neurology 2009;215(1):191-200.
2008: Cecilia Lundberg; Tomas Björklund; Thomas Carlsson; Johan Jakobsson; Philippe Hantraye; Nicole Deglon; Deniz Kirik
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.
Current gene therapy 2008;8(6):461-73.
2008: Heike Runne; Etienne Régulier; Alexandre Kuhn; Diana Zala; Ozgun Gokce; Valérie Perrin; Beate Sick; Patrick Aebischer; Nicole Deglon; Ruth Luthi-Carter
Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(39):9723-31.
2008: Sandro Alves; Etienne Régulier; Isabel Nascimento-Ferreira; Raymonde Hassig; Noelle Dufour; Arnulf Koeppen; Ana Luísa Carvalho; Sérgio Simões; Maria C Pedroso de Lima; Emmanuel Brouillet; Veronica F Colomer Gould; Nicole Deglon; Luis de Almeida
Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.
Human molecular genetics 2008;17(14):2071-83.
2008: Alexandra Benchoua; Yaël Trioulier; Elsa Diguet; Carole Malgorn; Marie-Claude Gaillard; Noelle Dufour; Jean-Marc Elalouf; Stan Krajewski; Philippe Hantraye; Nicole Deglon; Emmanuel Brouillet
Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.
Human molecular genetics 2008;17(10):1446-56.
2008: Stéphane Prost; Mikael Le Dantec; Sylvie Augé; Roger Le Grand; Sonia Derdouch; Gwenaelle Auregan; Nicole Deglon; Francis Relouzat; Anne-Marie Aubertin; Bernard Maillere; Isabelle Dusanter-Fourt; Marek Kirszenbaum
[Nef and PPAR-gamma interact to suppress Stat5 expression in CD34+ progenitors from infected macaques].
Médecine sciences : M/S 2008;24(5):551-3.
2008: Stéphane Prost; Mikael Le Dantec; Sylvie Augé; Roger Le Grand; Sonia Derdouch; Gwenaelle Auregan; Nicole Deglon; Francis Relouzat; Anne-Marie Aubertin; Bernard Maillere; Isabelle Dusanter-Fourt; Marek Kirszenbaum
Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques.
The Journal of clinical investigation 2008;118(5):1765-75.
2008: Sandro Alves; Isabel Nascimento-Ferreira; Gwennaëlle Auregan; Raymonde Hassig; Noëlle Dufour; Emmanuel Brouillet; Maria C Pedroso De Lima; Philippe Hantraye; Luis de Almeida; Nicole Deglon
Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.
PloS one 2008;3(10):e3341.
2008: Delphine Charvin; Emmanuel Roze; Valérie Perrin; Carole Deyts; Sandrine Betuing; Christiane Pagès; Etienne Régulier; Ruth Luthi-Carter; Emmanuel Brouillet; Nicole Deglon; Jocelyne Caboche
Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.
Neurobiology of disease 2008;29(1):22-9.
2007: Stéphane Palfi; Emmanuel Brouillet; Béchir Jarraya; Jocelyne Bloch; Caroline Jan; Masahiro Shin; Françoise Condé; Xiao-Jiang Li; Patrick Aebischer; Philippe Hantraye; Nicole Deglon
Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(8):1444-51.
2007: Carole Escartin; Karin Pierre; Angélique Colin; Emmanuel Brouillet; thierry delzescaux; Martine Guillermier; Marc Dhenain; Nicole Deglon; Philippe Hantraye; Luc Pellerin; Gilles Bonvento
Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(27):7094-104.
2007: Valérie Perrin; Etienne Régulier; Toufik Abbas-Terki; Raymonde Hassig; Emmanuel Brouillet; Patrick Aebischer; Ruth Luthi-Carter; Nicole Deglon
Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):903-11.
2007: Antonella Consiglio; Sabata Martino; Diego Dolcetta; Gabriella Cusella; Massimo Conese; Sergio Marchesini; Giuliana Benaglia; Lawrence Wrabetz; Antonio Orlacchio; Nicole Deglon; Patrick Aebischer; Giovanni Maria Severini; Claudio Bordignon
Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts.
Journal of the neurological sciences 2007;255(1-2):7-16.
2006: Carole Escartin; Emmanuel Brouillet; Paolo Gubellini; Yaël Trioulier; carine Jacquard; Claire Smadja; Graham W Knott; Lydia Kerkerian-Le Goff; Nicole Deglon; Philippe Hantraye; Gilles Bonvento
Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(22):5978-89.
2006: Margarita Arango; Sébastien Holbert; Diana Zala; Emmanuel Brouillet; James Pearson; Etienne Régulier; Ashwani Kumar Thakur; Patrick Aebischer; Ronald B. Wetzel; Nicole Deglon; Christian Néri
CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4649-59.
2006: Alexandra Benchoua; Yaël Trioulier; Diana Zala; Marie-Claude Gaillard; Nathalie Lefort; Noelle Dufour; Frédéric Saudou; Jean-Marc Elalouf; Etienne C Hirsch; Philippe Hantraye; Nicole Deglon; Emmanuel Brouillet
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin.
Molecular biology of the cell 2006;17(4):1652-63.
2006: Raúl Pardo; emilie colin; Etienne Régulier; Patrick Aebischer; Nicole Deglon; Sandrine Humbert; Frédéric Saudou
Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1635-45.
2006: Jean-Luc Ridet; Jean-Charles Bensadoun; Nicole Deglon; Patrick Aebischer; Anne D Zurn
Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease.
Neurobiology of disease 2006;21(1):29-34.
2005: Diana Zala; Alexandra Benchoua; Emmanuel Brouillet; Valérie Perrin; Marie-Claude Gaillard; Anne D Zurn; Patrick Aebischer; Nicole Deglon
Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment.
Neurobiology of disease 2005;20(3):785-98.
2005: Nicole Deglon; Philippe Hantraye
Viral vectors as tools to model and treat neurodegenerative disorders.
The journal of gene medicine 2005;7(5):530-9.
2005: emilie colin; Etienne Régulier; Valérie Perrin; Alexandra Dürr; Alexis Brice; Patrick Aebischer; Nicole Deglon; Sandrine Humbert; Frédéric Saudou
Akt is altered in an animal model of Huntington's disease and in patients.
The European journal of neuroscience 2005;21(6):1478-88.
2005: Kadiombo Bantubungi; carine Jacquard; Anita Greco; Annita Pintor; Abdelwahed Chtarto; Khalid Tai; Marie-Christine Galas; Liliane Tenenbaum; Nicole Deglon; Patrizia Popoli; Luisa Minghetti; Emmanuel Brouillet; Jacques Brotchi; Marc Levivier; Serge N Schiffmann; David Blum
Minocycline in phenotypic models of Huntington's disease.
Neurobiology of disease 2005;18(1):206-17.
2004: Christophe Lo Bianco; Nicole Deglon; William F Pralong; Patrick Aebischer
Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease.
Neurobiology of disease 2004;17(2):283-9.
2004: J Bloch; Anne-Catherine Bachoud-Lévi; Nicole Deglon; Jean-Pascal Lefaucheur; Laurence Winkel; Stéphane Palfi; Jean-Paul Nguyen; Catherine Bourdet; Véronique Gaura; Philippe Remy; Pierre Brugières; M-F Boisse; Sophie Baudic; Pierre Cesaro; Philippe Hantraye; Patrick Aebischer; Marc Peschanski
Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study.
Human gene therapy 2004;15(10):968-75.
2004: Frank Schwenter; Bernard L Schneider; William F Pralong; Nicole Deglon; Patrick Aebischer
Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions.
Human gene therapy 2004;15(7):669-80.
2004: Haruhiko Kishima; Thomas Poyot; Jocelyne Bloch; Julien Dauguet; Françoise Condé; Frédéric Dollé; Françoise Hinnen; William F Pralong; Stéphane Palfi; Nicole Deglon; Patrick Aebischer; Philippe Hantraye
Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons.
Neurobiology of disease 2004;16(2):428-39.
2004: Sandrine Guillot; Mimoun Azzouz; Nicole Deglon; Anne D Zurn; Patrick Aebischer
Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice.
Neurobiology of disease 2004;16(1):139-49.
2004: Etienne Régulier; Diana Zala; Patrick Aebischer; Nicole Deglon
Lentiviral-mediated gene transfer to model triplet repeat disorders.
Methods in molecular biology (Clifton, N.J.) 2004;277():199-213.
2004: Diana Zala; Jean-Charles Bensadoun; Luis de Almeida; Blair R Leavitt; Claire-Anne Gutekunst; Patrick Aebischer; Michael R Hayden; Nicole Deglon
Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice.
Experimental neurology 2004;185(1):26-35.
2003: Etienne Régulier; Yvon Trottier; Valérie Perrin; Patrick Aebischer; Nicole Deglon
Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum.
Human molecular genetics 2003;12(21):2827-36.
2003: Sylvain Fleury; Eleonora Simeoni; Christian Zuppinger; Nicole Deglon; Ludwig K von Segesser; Lukas Kappenberger; Giuseppe Vassalli
Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo.
Circulation 2003;107(18):2375-82.
2003: Corinne Kostic; F Chiodini; P Salmon; M Wiznerowicz; Nicole Deglon; Dana Hornfeld; D Trono; Patrick Aebischer; Daniel F Schorderet; Francis L Munier; Yvan Arsenijevic
Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina.
Gene therapy 2003;10(9):818-21.
2003: Nicole Deglon; Vincent Aubert; François Spertini; Laurence Winkel; Patrick Aebischer
Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology.
Xenotransplantation 2003;10(3):204-13.
2003: Frank Schwenter; Nicole Deglon; Patrick Aebischer
Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy.
The journal of gene medicine 2003;5(3):246-57.
2003: Jean-Charles Bensadoun; Luis de Almeida; Eric G Fine; Jack L Tseng; Nicole Deglon; Patrick Aebischer
Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):107-15.
2003: Brian A van Adel; Corinne Kostic; Nicole Deglon; Alexander K Ball; Yvan Arsenijevic
Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time.
Human gene therapy 2003;14(2):103-15.
2002: Toufik Abbas-Terki; William E Blanco-Bose; Nicole Deglon; William F Pralong; Patrick Aebischer
Lentiviral-mediated RNA interference.
Human gene therapy 2002;13(18):2197-201.
2002: Etienne Régulier; Luis de Almeida; B Sommer; Patrick Aebischer; Nicole Deglon
Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.
Human gene therapy 2002;13(16):1981-90.
2002: Christopher Rinsch; philippe Dupraz; Bernard L Schneider; Nicole Deglon; Patrick H Maxwell; Peter J Ratcliffe; Patrick Aebischer
Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.
Kidney international 2002;62(4):1395-401.
2002: Thor Ostenfeld; Yu-Tzu Tai; Peter Martin; Nicole Deglon; Patrick Aebischer; Clive Svendsen
Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons.
Journal of neuroscience research 2002;69(6):955-65.
2002: Christophe Lo Bianco; J-L Ridet; Bernard L Schneider; Nicole Deglon; Patrick Aebischer
alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10813-8.
2002: Detlev Boison; Alexander Huber; Vivianne Padrun; Nicole Deglon; Patrick Aebischer; Hanns Möhler
Seizure suppression by adenosine-releasing cells is independent of seizure frequency.
Epilepsia 2002;43(8):788-96.
2002: Birgit Sommer; Christopher Rinsch; Emmanuel Payen; Bruno Dalle; Bernard Schneider; Nicole Deglon; Annie Henri; Yves Beuzard; Patrick Aebischer
Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):155-61.
2002: Stéphane Palfi; Liza Leventhal; Yaping Chu; Shuang Y Ma; Marina E Emborg; Roy A E Bakay; Nicole Deglon; Philippe Hantraye; Patrick Aebischer; Jeffrey Kordower
Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(12):4942-54.
2002: Luis de Almeida; Christopher A Ross; Diana Zala; Patrick Aebischer; Nicole Deglon
Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3473-83.
2002: Nicole Deglon; Patrick Aebischer
Lentiviruses as vectors for CNS diseases.
Current topics in microbiology and immunology 2002;261():191-209.
2001: Jean-Charles Bensadoun; Luis de Almeida; M Dréano; Patrick Aebischer; Nicole Deglon
Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome.
The European journal of neuroscience 2001;14(11):1753-61.
2001: Yvan Arsenijevic; Jean-Guy Villemure; Jean-François Brunet; J J Bloch; Nicole Deglon; Corinne Kostic; Anne D Zurn; Patrick Aebischer
Isolation of multipotent neural precursors residing in the cortex of the adult human brain.
Experimental neurology 2001;170(1):48-62.
2001: Alexander Huber; Vivianne Padrun; Nicole Deglon; Patrick Aebischer; Hanns Möhler; Detlev Boison
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7611-6.
2001: Luis de Almeida; Diana Zala; Patrick Aebischer; Nicole Deglon
Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.
Neurobiology of disease 2001;8(3):433-46.
2001: Markus U Ehrengruber; Sonia Hennou; Hansruedi Büeler; Hussein Y Naim; Nicole Deglon; Kenneth Lundstrom
Gene transfer into neurons from hippocampal slices: comparison of recombinant Semliki Forest Virus, adenovirus, adeno-associated virus, lentivirus, and measles virus.
Molecular and cellular neurosciences 2001;17(5):855-71.
2000: Jeffrey Kordower; Marina E Emborg; J Bloch; Shuang Y Ma; Yaping Chu; Liza Leventhal; J McBride; Er-Yun Chen; Stéphane Palfi; Ben Roitberg; WD Brown; James E Holden; Robert W Pyzalski; MD Taylor; Paul Carvey; Z Ling; D Trono; Philippe Hantraye; Nicole Deglon; Patrick Aebischer
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
Science (New York, N.Y.) 2000;290(5492):767-73.
2000: Anne-Catherine Bachoud-Lévi; Nicole Deglon; Jean-Paul Nguyen; J Bloch; Catherine Bourdet; Laurence Winkel; Philippe Rémy; M Goddard; Jean-Pascal Lefaucheur; Pierre Brugières; Sophie Baudic; Pierre Cesaro; Marc Peschanski; Patrick Aebischer
Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF.
Human gene therapy 2000;11(12):1723-9.
2000: AF Hottinger; Mimoun Azzouz; Nicole Deglon; Patrick Aebischer; Anne D Zurn
Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(15):5587-93.
2000: Jean-Charles Bensadoun; Nicole Deglon; Jack L Tseng; Jean-Luc Ridet; Anne D Zurn; Patrick Aebischer
Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF.
Experimental neurology 2000;164(1):15-24.
2000: Vincent Mittoux; J M Joseph; F Conde; Stéphane Palfi; C Dautry; Thomas Poyot; Jocelyne Bloch; Nicole Deglon; Stéphane Ouary; E A Nimchinsky; Emmanuel Brouillet; Patrick R Hof; Marc Peschanski; Patrick Aebischer; Philippe Hantraye
Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.
Human gene therapy 2000;11(8):1177-87.
2000: C Cisterni; Christopher E Henderson; Patrick Aebischer; Brigitte Pettmann; Nicole Deglon
Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors.
Journal of neurochemistry 2000;74(5):1820-8.
2000: Jean-Luc Ridet; Nicole Deglon; Patrick Aebischer
Gene transfer techniques for the delivery of GDNF in Parkinson's disease.
Novartis Foundation symposium 2000;231():202-15; discussion 215-9, 302-6.
2000: Nicole Deglon; Jack L Tseng; Jean-Charles Bensadoun; Anne D Zurn; Yvan Arsenijevic; Luis de Almeida; R Zufferey; Didier Trono; Patrick Aebischer
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease.
Human gene therapy 2000;11(1):179-90.
1999: Jeffrey Kordower; J Bloch; Shuang Y Ma; Yaping Chu; Stéphane Palfi; Ben Roitberg; Marina E Emborg; Philippe Hantraye; Nicole Deglon; Patrick Aebischer
Lentiviral gene transfer to the nonhuman primate brain.
Experimental neurology 1999;160(1):1-16.
1999: Patrick Aebischer; AF Hottinger; Nicole Deglon
Cellular xenotransplantation.
Nature medicine 1999;5(8):852.
1999: Bruno Dalle; Emmanuel Payen; E Regulier; Nicole Deglon; Philippe Rouyer-Fessard; Yves Beuzard; Patrick Aebischer
Improvement of mouse beta-thalassemia upon erythropoietin delivery by encapsulated myoblasts.
Gene therapy 1999;6(2):157-61.
1998: Etienne Régulier; Bernard L Schneider; Nicole Deglon; Yves Beuzard; Patrick Aebischer
Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts.
Gene therapy 1998;5(8):1014-22.
1998: Anne D Zurn; Jack L Tseng; Nicole Deglon; J M Joseph; Patrick Aebischer
A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease.
Advances in pharmacology (San Diego, Calif.) 1998;42():929-31.
1997: Christopher Rinsch; Etienne Régulier; Nicole Deglon; Bruno Dalle; Yves Beuzard; Patrick Aebischer
A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension.
Human gene therapy 1997;8(16):1881-9.
1996: Nicole Deglon; B Heyd; S A Tan; J M Joseph; Anne D Zurn; Patrick Aebischer
Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts.
Human gene therapy 1996;7(17):2135-46.
1996: S A Tan; Nicole Deglon; Anne D Zurn; E E Baetge; B Bamber; Ann C Kato; Patrick Aebischer
Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF.
Cell transplantation 1996;5(5):577-87.
1996: Patrick Aebischer; Myriam Schluep; Nicole Deglon; J M Joseph; Lorenz Hirt; B Heyd; M Goddard; J P Hammang; Anne D Zurn; Ann C Kato; F Regli; E E Baetge
Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients.
Nature medicine 1996;2(6):696-9.
1996: Patrick Aebischer; N A Pochon; B Heyd; Nicole Deglon; J M Joseph; Anne D Zurn; E E Baetge; J P Hammang; M Goddard; M Lysaght; F Kaplan; Ann C Kato; Myriam Schluep; Lorenz Hirt; F Regli; François Porchet; Nicolas de Tribolet
Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF.
Human gene therapy 1996;7(7):851-60.
1995: Nicole Deglon; A Wilson; Chantal Desponds; P Laurent; Claude Bron; Nicolas Fasel
Fatty acids regulate Thy-1 antigen mRNA stability in T lymphocyte precursors.
European journal of biochemistry / FEBS 1995;231(3):687-96.
1994: Nicolas Fasel; Nicole Deglon; C Beghdadi-Rais; R Law; Claude Bron; R Wall
Minimal membrane and secreted mu poly(A) signals specify developmentally-regulated immunoglobulin heavy chain mRNA ratios without RNA splicing.
Molecular immunology 1994;31(7):563-6.
1992: Nicolas Fasel; M Rousseaux; Nicole Deglon; H L Govan; R Law; Claude Bron; R Wall
Membrane mu poly(A) signal and 3' flanking sequences function as a transcription terminator for immunoglobulin-encoding genes.
Gene 1992;122(2):297-304.
1992: Nicolas Fasel; Nicole Deglon
Multi-level regulation of Thy-1 antigen expression in mouse T lymphomas.
Immunogenetics 1992;35(2):126-30.
1991: Nicolas Fasel; Nicole Deglon; M Rousseaux; C Beghdadi-Rais; M Bernard; Claude Bron
Evaluation of somatic cell variants deficient in glycosylphosphatidyl-inositol anchoring as candidates for genetic correction.
Cell biology international reports 1991;15(11):1051-64.
1991: Nicolas Fasel; M Bernard; Nicole Deglon; M Rousseaux; R J Eisenberg; Claude Bron; Gary cohen
Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).
Biochemical and biophysical research communications 1991;178(1):8-15.
1991: Nicole Deglon; A Krapp; Claude Bron; Nicolas Fasel
Translocation of the yeast dolichol-phosphate-mannose synthase into microsomal membranes.
Biochemical and biophysical research communications 1991;174(3):1337-42.