Ian Holt

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Caroline A Sewry; Ros C M Quinlivan; Waney Squier; Glenn E Morris; Ian Holt
A rapid immunohistochemical test to distinguish congenital myotonic dystrophy from X-linked myotubular myopathy.
Sharan Paul; Warunee Dansithong; Sonali P Jog; Ian Holt; Saloni Mittal; J David Brook; Glenn E Morris; Lucio Comai; Sita Reddy
Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.
Ian Holt; Le Thanh Lam; Stéphanie Tomé; Derick G Wansink; Hein Te Riele; Geneviève Gourdon; Glenn E Morris
The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress.

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All Publications

2012: Caroline A Sewry; Ros C M Quinlivan; Waney Squier; Glenn E Morris; Ian Holt
A rapid immunohistochemical test to distinguish congenital myotonic dystrophy from X-linked myotubular myopathy.
Neuromuscular disorders : NMD 2012;22(3):225-30.
2011: Sharan Paul; Warunee Dansithong; Sonali P Jog; Ian Holt; Saloni Mittal; J David Brook; Glenn E Morris; Lucio Comai; Sita Reddy
Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.
The Journal of biological chemistry 2011;286(44):38427-38.
2011: Ian Holt; Le Thanh Lam; Stéphanie Tomé; Derick G Wansink; Hein Te Riele; Geneviève Gourdon; Glenn E Morris
The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress.
Journal of cellular biochemistry 2011;112(6):1612-21.
2011: Hélène Tran; Nathalie Gourrier; Camille Lemercier-Neuillet; Claire-Marie Dhaenens; Audrey Vautrin; Francisco José Fernandez-Gomez; Ludovic Arandel; Céline Carpentier; Hélène Obriot; Sabiha Eddarkaoui; et al.
Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms.
The Journal of biological chemistry 2011;286(18):16435-46.
2011: Eva A L Wielders; Rob J Dekker; Ian Holt; Glenn E Morris; Hein te Riele
Characterization of MSH2 variants by endogenous gene modification in mouse embryonic stem cells.
Human mutation 2011;32(4):389-96.
2009: Stéphanie Tomé; Ian Holt; Winfried Edelmann; Glenn E Morris; Arnold Munnich; Christopher E Pearson; Geneviève Gourdon
MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.
PLoS genetics 2009;5(5):e1000482.
2009: Ian Holt; Virginie Jacquemin; Majid Fardaei; Caroline A Sewry; Gillian S Butler-Browne; Denis Furling; J David Brook; Glenn E Morris
Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle.
The American journal of pathology 2009;174(1):216-27.
2008: Warunee Dansithong; Cordula M Wolf; Partha Sarkar; Sharan Paul; Andy Chiang; Ian Holt; Glenn E Morris; Dorothy Branco; Megan C Sherwood; Lucio Comai; et al.
Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features.
PloS one 2008;3(12):e3968.
2007: Ian Holt; Saloni Mittal; Denis Furling; Gillian S Butler-Browne; J David Brook; Glenn E Morris
Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(9):1035-48.
2007: Elizabeth C Wolstencroft; Goran Simic; Nguyen thi Man; Ian Holt; Le Thanh Lam; Paul R Buckland; Glenn E Morris
Endosomal location of dopamine receptors in neuronal cell cytoplasm.
Journal of molecular histology 2007;38(4):333-40.
2006: Ian Holt; Thi Man Nguyen; Manfred Wehnert; Glenn E Morris
Lamin A/C assembly defects in Emery-Dreifuss muscular dystrophy can be regulated by culture medium composition.
Neuromuscular disorders : NMD 2006;16(6):368-73.
2005: Y Chan N Pham; Nguyen thi Man; Ian Holt; Caroline A Sewry; Gurman Pall; Keith Johnson; Glenn E Morris
Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies.
Journal of cellular biochemistry 2005;95(5):990-1001.
2003: Ian Holt; Cecilia Ostlund; Colin L Stewart; Nguyen thi Man; Howard J Worman; Glenn E Morris
Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo.
Journal of cell science 2003;116(Pt 14):3027-35.
2003: Fiona L Wilkinson; James M Holaska; Zhayi Zhang; Aarti Sharma; Sushila Manilal; Ian Holt; Stefan Stamm; Katherine L Wilson; Glenn E Morris
Emerin interacts in vitro with the splicing-associated factor, YT521-B.
European journal of biochemistry / FEBS 2003;270(11):2459-66.
2001: I Holt; L Clements; S Manilal; G E Morris
How does a g993t mutation in the emerin gene cause Emery-Dreifuss muscular dystrophy?
Biochemical and biophysical research communications 2001;287(5):1129-33.
2001: I Holt; L Clements; S Manilal; S C Brown; G E Morris
The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin.
European journal of human genetics : EJHG 2001;9(3):204-8.
1998: I Holt; M J Marshall
Integrin subunit beta3 plays a crucial role in the movement of osteoclasts from the periosteum to the bone surface.
Journal of cellular physiology 1998;175(1):1-9.
1996: M J Marshall; I Holt; M W Davie
Inhibition of prostaglandin synthesis leads to a change in adherence of mouse osteoclasts from bone to periosteum.
Calcified tissue international 1996;59(3):207-13.
1996: I Holt; M W Davie; M J Marshall
Osteoclasts are not the major source of interleukin-6 in mouse parietal bones.
Bone 1996;18(3):221-6.
1995: M J Marshall; I Holt; M W Davie
The number of tartrate-resistant acid phosphatase-positive osteoclasts on neonatal mouse parietal bones is decreased when prostaglandin synthesis is inhibited and increased in response to prostaglandin E2, parathyroid hormone, and 1,25 dihydroxyvitamin D3.
Calcified tissue international 1995;56(3):240-5.
1994: I Holt; M W Davie; I P Braidman; M J Marshall
Interleukin-6 does not mediate the stimulation by prostaglandin E2, parathyroid hormone, or 1,25 dihydroxyvitamin D3 of osteoclast differentiation and bone resorption in neonatal mouse parietal bones.
Calcified tissue international 1994;55(2):114-9.
1994: I Holt; M W Davie; I P Braidman; M J Marshall
Prostaglandin E2 stimulates the production of interleukin-6 by neonatal mouse parietal bones.
Bone and mineral 1994;25(1):47-57.
1994: I Holt; M J Marshall; M W Davie
Pamidronate stimulates recruitment and decreases longevity of osteoclast nuclei in mice.
Seminars in arthritis and rheumatism 1994;23(4):263-4.
1993: M J Marshall; I Holt; M W Davie
Osteoclast recruitment in mice is stimulated by (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate.
Calcified tissue international 1993;52(1):21-5.
1992: I Holt; R G Cooper; J Denton; A Meager; S J Hopkins
Cytokine inter-relationships and their association with disease activity in arthritis.
British journal of rheumatology 1992;31(11):725-33.
1991: I Holt; R G Cooper; S J Hopkins
Relationships between local inflammation, interleukin-6 concentration and the acute phase protein response in arthritis patients.
European journal of clinical investigation 1991;21(5):479-84.