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Tobias Hartmann

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Marcus Otto Walter Grimm; Sven Grösgen; Heike S Grimm; Viola J Haupenthal; Benjamin Hundsdörfer; Johannes Lehmann; Tatjana L Rothhaar; Valerie C Zimmer; Tobias Hartmann
Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.
Marcus Otto Walter Grimm; Sven Grösgen; Verena K Burg; Petra Friess; Heike S Grimm; Viola J Haupenthal; Benjamin Hundsdörfer; Stefan Kins; Tatjana L Rothhaar; Tobias Hartmann
Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).
Manuela Gries; Tobias Hartmann; Yang Liu; Jörg Spiegel; Armin Bachhuber; Laura Davies; Ulrich Dillmann; Klaus Fassbender; Silke Walter
Response of Toll-like receptors in experimental Guillain-Barré syndrome: a kinetic analysis.

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2013: Marcus Otto Walter Grimm; Sven Grösgen; Heike S Grimm; Viola J Haupenthal; Benjamin Hundsdörfer; Johannes Lehmann; Tatjana L Rothhaar; Valerie C Zimmer; Tobias Hartmann
Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.
International journal of molecular sciences 2013;14(3):5879-98.
2012: Marcus Otto Walter Grimm; Sven Grösgen; Verena K Burg; Petra Friess; Heike S Grimm; Viola J Haupenthal; Benjamin Hundsdörfer; Stefan Kins; Tatjana L Rothhaar; Tobias Hartmann
Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).
The Journal of nutritional biochemistry 2012;23(10):1214-23.
2012: Manuela Gries; Tobias Hartmann; Yang Liu; Jörg Spiegel; Armin Bachhuber; Laura Davies; Ulrich Dillmann; Klaus Fassbender; Silke Walter
Response of Toll-like receptors in experimental Guillain-Barré syndrome: a kinetic analysis.
Neuroscience letters 2012;518(2):154-60.
2012: Tim Vanmierlo; Oliver Weingärtner; Monique Mulder; Eric Sijbrands; Harry Steinbusch; Susanne van der Pol; Michael Böhm; Helga E de Vries; Silvia Friedrichs; Marcus Otto Walter Grimm; Tobias Hartmann; Constanze Husche; Anja Kerksiek; Ulrich Laufs; Dieter Lütjohann
Dietary intake of plant sterols stably increases plant sterol levels in the murine brain.
Journal of lipid research 2012;53(4):726-35.
2012: Marcus Otto Walter Grimm; Tatjana L Rothhaar; Tobias Hartmann
The role of APP proteolytic processing in lipid metabolism.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2012;217(3-4):365-75.
2012: Shirong Liu; Yang Liu; Michael D Menger; Botond Penke; Claudia E Rübe; Jochen Walter; Lisa Wolf; Wenlin Hao; Tobias Hartmann; Michael T Heneka; Amanda J Kiliaan; Klaus Fassbender
TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1098-107.
2012: Tatjana L Rothhaar; Verena K Burg; Heike S Grimm; Sven Grösgen; Tobias Hartmann; Viola J Haupenthal; Benjamin Hundsdörfer; Janine Mett; Matthias Riemenschneider; Marcus Otto Walter Grimm
Plasmalogens inhibit APP processing by directly affecting γ-secretase activity in Alzheimer's disease.
TheScientificWorldJournal 2012;2012():141240.
2012: Marcus Otto Walter Grimm; Sven Grösgen; Thomas A Bayer; Verena K Burg; Heike S Grimm; Benjamin Hundsdörfer; Lars Kaestner; Peter Lipp; Ulrike Müller; Tatjana L Rothhaar; Eva G Zinser; Tobias Hartmann
Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.
PloS one 2012;7(3):e34095.
2012: Zehavit Kariv-Inbal; Dieter Lütjohann; Maria Peter; Shiri Yacobson; Róbert Berkecz; Laus M Broersen; Tobias Hartmann; Tamas Janaky; Daniel M Michaelson
The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol.
Journal of Alzheimer's disease : JAD 2012;28(3):667-83.
2011: Marcus Otto Walter Grimm; Sven Grösgen; Matthias Riemenschneider; Heikki Tanila; Heike S Grimm; Tobias Hartmann
From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry.
Journal of chromatography. A 2011;1218(42):7713-22.
2011: Tobias Hartmann; Alessandro Prinetti
Going the wrong road: Fyn and targeting of amyloid precursor protein to lipid rafts.
Journal of neurochemistry 2011;118(5):677-9.
2011: Tim Vanmierlo; Klaus Von Bergmann; T Bertsch; S Friedrichs; Tobias Hartmann; F Jessen; Heike Kölsch; W Maier; Monique Mulder; J Popp; H Steinbusch; B Stoffel-Wagner; Dieter Lütjohann
The plant sterol brassicasterol as additional CSF biomarker in Alzheimer's disease.
Acta psychiatrica Scandinavica 2011;124(3):184-92.
2011: Marcus Otto Walter Grimm; Johanna Kuchenbecker; Sven Grösgen; Verena K Burg; Benjamin Hundsdörfer; Tatjana L Rothhaar; Petra Friess; m de wilde; Laus M Broersen; Botond Penke; Mária Péter; László Vígh; Heike S Grimm; Tobias Hartmann
Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.
The Journal of biological chemistry 2011;286(16):14028-39.
2011: Marcus Otto Walter Grimm; Johanna Kuchenbecker; Tatjana L Rothhaar; Sven Grösgen; Benjamin Hundsdörfer; Verena K Burg; Petra Friess; Ulrike Müller; Heike S Grimm; Mathias Riemenschneider; Tobias Hartmann
Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.
Journal of neurochemistry 2011;116(5):916-25.
2011: Marcus Otto Walter Grimm; Sven Grösgen; Verena K Burg; Klaus Fassbender; Petra Friess; Heike S Grimm; Viola J Haupenthal; Benjamin Hundsdörfer; Ulrike Müller; Matthias Riemenschneider; Tatjana L Rothhaar; Tobias Hartmann
Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.
International journal of Alzheimer's disease 2011;2011():695413.
2011: Wenlin Hao; Yang Liu; Shirong Liu; Silke Walter; Marcus Otto Walter Grimm; Amanda J Kiliaan; Botond Penke; Tobias Hartmann; Claudia E Rübe; Michael D Menger; Klaus Fassbender
Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology.
Brain : a journal of neurology 2011;134(Pt 1):278-92.
2010: Sven Grösgen; Marcus Otto Walter Grimm; Petra Friess; Tobias Hartmann
Role of amyloid beta in lipid homeostasis.
Biochimica et biophysica acta 2010;1801(8):966-74.
2009: Nicolaas Verwey; W M van der Flier; Kaj Blennow; C Clark; S Sokolow; P P De Deyn; Douglas Galasko; Harald Hampel; Tobias Hartmann; E Kapaki; Lars Lannfelt; P D Mehta; L Parnetti; Axel Petzold; T Pirttila; L Saleh; A Skinningsrud; J C V Swieten; M M Verbeek; J Wiltfang; Steven G Younkin; Philip scheltens; Marinus A Blankenstein
A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease.
Annals of clinical biochemistry 2009;46(Pt 3):235-40.
2009: Markus Uhrig; Carina Ittrich; Verena Wiedmann; Yuri Knyazev; Annette Weninger; Matthias Riemenschneider; Tobias Hartmann
New Alzheimer amyloid beta responsive genes identified in human neuroblastoma cells by hierarchical clustering.
PloS one 2009;4(8):e6779.
2008: Marcus Otto Walter Grimm; Heike S Grimm; Inge Tomic; Konrad Beyreuther; Tobias Hartmann; Christine Bergmann
Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels.
The Journal of biological chemistry 2008;283(17):11302-11.
2008: Yasmine Nadler; Alexander Alexandrovich; Nikolaos Grigoriadis; Tobias Hartmann; Kosagi S Jagannatha Rao; Esther Shohami; Reuven Stein
Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.
Glia 2008;56(5):552-67.
2008: Markus Uhrig; Peter Brechlin; Olaf Jahn; Yuri Knyazev; Annette Weninger; Laura Busia; Kamran Honarnejad; Markus Otto; Tobias Hartmann
Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Abeta42 reduces their differentiation potential.
BMC medicine 2008;6():38.
2007: Tobias Hartmann; Johannna Kuchenbecker; Marcus Otto Walter Grimm
Alzheimer's disease: the lipid connection.
Journal of neurochemistry 2007;103 Suppl 1():159-70.
2007: Marcus Otto Walter Grimm; Heike S Grimm; Tobias Hartmann
Amyloid beta as a regulator of lipid homeostasis.
Trends in molecular medicine 2007;13(8):337-44.
2007: Eva G Zinser; Tobias Hartmann; Marcus Otto Walter Grimm
Amyloid beta-protein and lipid metabolism.
Biochimica et biophysica acta 2007;1768(8):1991-2001.
2007: Maryse Letiembre; Wenlin Hao; Yang Liu; Silke Walter; I Mihaljevic; Serge Rivest; Tobias Hartmann; Klaus Fassbender
Innate immune receptor expression in normal brain aging.
Neuroscience 2007;146(1):248-54.
2006: Zhonghua Liu; Yan Ruan; Weihua Yue; Zhihui Zhu; Tobias Hartmann; Konrad Beyreuther; Dai Zhang
GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons.
Neuroscience letters 2006;407(1):59-63.
2006: Anja Schneider; Walter Schulz-Schaeffer; Tobias Hartmann; Jörg B Schulz; Mikael Simons
Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons.
Neurobiology of disease 2006;23(3):573-7.
2006: Mari Oksman; Hennariikka Iivonen; E Hogyes; Z Amtul; B Penke; I Leenders; Laus M Broersen; D Lütjohann; Tobias Hartmann; Heikki Tanila
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice.
Neurobiology of disease 2006;23(3):563-72.
2006: Jakob Tschaepe; Tobias Hartmann
Therapeutic perspectives in Alzheimer's disease.
Recent patents on CNS drug discovery 2006;1(1):119-27.
2006: Tobias Hartmann
Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance.
Neuro-degenerative diseases 2006;3(4-5):305-11.
2006: Marcus Otto Walter Grimm; Jakob Tschaepe; Heike S Grimm; Eva G Zinser; Tobias Hartmann
Altered membrane fluidity and lipid raft composition in presenilin-deficient cells.
Acta neurologica Scandinavica. Supplementum 2006;185():27-32.
2005: Leonid Yavich; Mari Oksman; Heikki Tanila; Petri Kerokoski; Mikko Hiltunen; Thomas van Groen; Jukka Puoliväli; Pekka T Männistö; Arturo García-Horsman; Ewen MacDonald; Konrad Beyreuther; Tobias Hartmann; Pekka Jäkälä
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.
Neurobiology of disease 2005;20(2):303-13.
2005: Marcus Otto Walter Grimm; Heike S Grimm; Andreas J Pätzold; Eva G Zinser; Riikka Halonen; Marco Duering; Jakob Tschaepe; Bart De Strooper; Ulrike Müller; Jie Shen; Tobias Hartmann
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.
Nature cell biology 2005;7(11):1118-23.
2005: Ofir Levi; Dieter Lütjohann; Aliza Devir; Klaus Von Bergmann; Tobias Hartmann; Daniel M Michaelson
Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation.
Journal of neurochemistry 2005;95(4):987-97.
2005: Marco Duering; Marcus Otto Walter Grimm; Heike S Grimm; Johannes Schröder; Tobias Hartmann
Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.
Neurobiology of aging 2005;26(6):785-8.
2005: Wenxue Li; Neva West; Emanuela Colla; Olga Pletnikova; Juan C Troncoso; Laura Marsh; Ted M Dawson; Pekka Jäkälä; Tobias Hartmann; Donald L Price; Michael K Lee
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2162-7.
2004: Q Zha; Yan Ruan; Tobias Hartmann; Konrad Beyreuther; Dai Zhang
GM1 ganglioside regulates the proteolysis of amyloid precursor protein.
Molecular psychiatry 2004;9(10):946-52.
2004: Valentina Echeverria Moran; Adriana Ducatenzeiler; E Dowd; J Jänne; Susan M Grant; Moshe Szyf; Francisco Wandosell; Jesús Avila; H Grimm; Stephen B Dunnett; Tobias Hartmann; Leena Alhonen; A Claudio Cuello
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.
Neuroscience 2004;129(3):583-92.
2004: Klaus Fassbender; Silke Walter; Sandra Kühl; Regine Landmann; K Ishii; Thomas Bertsch; Anna K Stalder; Frank Muehlhauser; Yang Liu; Artur J Ulmer; Serge Rivest; Arnd Lentschat; E Gulbins; Mathias Jucker; Matthias Staufenbiel; Katrin Brechtel; J Walter; Gerd Multhaup; Botond Penke; Y Adachi; Tobias Hartmann; Konrad Beyreuther
The LPS receptor (CD14) links innate immunity with Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):203-5.
2003: Peter Schönknecht; Johannes Pantel; Tobias Hartmann; Egon Werle; Martin Volkmann; Marco Essig; Michael Amann; Nadja Zanabili; Hubert J Bardenheuer; Aoife Hunt; Johannes Schröder
Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy.
Psychiatry research 2003;120(3):231-8.
2003: Heike S Grimm; Dirk Beher; Stefan F Lichtenthaler; Mark S Shearman; Konrad Beyreuther; Tobias Hartmann
gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.
The Journal of biological chemistry 2003;278(15):13077-85.
2003: Beate Grziwa; Marcus Otto Walter Grimm; Colin L Masters; Konrad Beyreuther; Tobias Hartmann; Stefan F Lichtenthaler
The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted.
The Journal of biological chemistry 2003;278(9):6803-8.
2003: Amir Gamliel; C Teicher; Tobias Hartmann; Konrad Beyreuther; Reuven Stein
Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines.
Neuroscience 2003;117(1):19-28.
2002: Mikael Simons; Frank Schwärzler; Dieter Lütjohann; Klaus Von Bergmann; Konrad Beyreuther; Johannes Dichgans; Henning Wormstall; Tobias Hartmann; Jörg B Schulz
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial.
Annals of neurology 2002;52(3):346-50.
2002: Marcus Otto Walter Grimm; Inge Tomic; Tobias Hartmann
Potential external source of A beta in biological samples.
Nature cell biology 2002;4(7):E164-5; author reply E165-6.
2002: Peter Schönknecht; Dieter Lütjohann; Johannes Pantel; Hubert J Bardenheuer; Tobias Hartmann; Klaus Von Bergmann; Konrad Beyreuther; Johannes Schröder
Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls.
Neuroscience letters 2002;324(1):83-5.
2002: Heiko Runz; Jens Rietdorf; Inge Tomic; Marina de Bernard; Konrad Beyreuther; Rainer Pepperkok; Tobias Hartmann
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1679-89.
2002: Amir Gamliel; Carmit Teicher; Daniel M Michaelson; Laurent Pradier; Tobias Hartmann; Konrad Beyreuther; Reuven Stein
Increased expression of presenilin 2 inhibits protein synthesis.
Molecular and cellular neurosciences 2002;19(1):111-24.
2001: Imrich Blasko; A Apochal; G Boeck; Tobias Hartmann; Beatrix Grubeck-Loebenstein; Gerhard Ransmayr
Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells.
Neurobiology of disease 2001;8(6):1094-101.
2001: Tobias Hartmann
Cholesterol, A beta and Alzheimer's disease.
Trends in neurosciences 2001;24(11 Suppl):S45-8.
2001: Marek Jauss; K Herholz; L Kracht; Johannes Pantel; Tobias Hartmann; M Jensen; M Essig; J Schröder
Frontotemporal dementia: clinical, neuroimaging, and molecular biological findings in 6 patients.
European archives of psychiatry and clinical neuroscience 2001;251(5):225-31.
2001: Peter Schönknecht; Johannes Pantel; Klaus Klinga; M Jensen; Tobias Hartmann; Birgit Salbach; Johannes Schröder
Reduced cerebrospinal fluid estradiol levels are associated with increased beta-amyloid levels in female patients with Alzheimer's disease.
Neuroscience letters 2001;307(2):122-4.
2001: Klaus Fassbender; M Simons; C Bergmann; Mark Stroick; D Lutjohann; P Keller; H Runz; S Kuhl; Thomas Bertsch; Klaus Von Bergmann; Michael Hennerici; Konrad Beyreuther; Tobias Hartmann
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5856-61.
2001: Thomas A Bayer; Oliver Wirths; K Majtényi; Tobias Hartmann; Gerd Multhaup; Konrad Beyreuther; Christian Czech
Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.
Brain pathology (Zurich, Switzerland) 2001;11(1):1-11.
2000: P Schonknecht; Johannes Pantel; Egon Werle; Tobias Hartmann; Marco Essig; Klaus T Baudendistel; Konrad Beyreuther; Johannes Schroder
[Cerebrospinal fluid protein tau levels in the differential diagnosis of Alzheimer's disease].
Fortschritte der Neurologie-Psychiatrie 2000;68(10):439-46.
2000: C Leloup; Daniel M Michaelson; Abraham Fisher; Tobias Hartmann; Konrad Beyreuther; Reuven Stein
M1 muscarinic receptors block caspase activation by phosphoinositide 3-kinase- and MAPK/ERK-independent pathways.
Cell death and differentiation 2000;7(9):825-33.
2000: K Ishii; F Muelhauser; U Liebl; M Picard; Sandra Kühl; Botond Penke; Thomas A Bayer; M Wiessler; Michael Hennerici; Konrad Beyreuther; Tobias Hartmann; Klaus Fassbender
Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1485-9.
2000: M Jensen; Tobias Hartmann; Benita Engvall; Rong Wang; S N Uljon; Kristina Sennvik; Jan Näslund; F Muehlhauser; C Nordstedt; Konrad Beyreuther; Lars Lannfelt
Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems.
Molecular medicine (Cambridge, Mass.) 2000;6(4):291-302.
1999: Janetta G Culvenor; Catriona A McLean; S Cutt; Bruce C V Campbell; Fran Maher; P Jäkälä; Tobias Hartmann; Konrad Beyreuther; Colin L Masters; Qiao-Xin Li
Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.
The American journal of pathology 1999;155(4):1173-81.
1999: Thomas A Bayer; P Jäkälä; Tobias Hartmann; R Egensperger; R Buslei; Peter Falkai; Konrad Beyreuther
Neural expression profile of alpha-synuclein in developing human cortex.
Neuroreport 1999;10(13):2799-803.
1999: Graham R Christie; RE Markwell; Carol W Gray; L Smith; F Godfrey; F Mansfield; H Wadsworth; R King; M McLaughlin; D G Cooper; RV Ward; David R Howlett; Tobias Hartmann; S F Lichtenthaler; Konrad Beyreuther; J Underwood; S K Gribble; Roberto Cappai; Colin L Masters; A Tamaoka; R L Gardner; A Jennifer Rivett; EH Karran; D Allsop
Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.
Journal of neurochemistry 1999;73(1):195-204.
1999: Thomas A Bayer; P Jäkälä; Tobias Hartmann; L Havas; C McLean; Janetta G Culvenor; Qiao-Xin Li; Colin L Masters; Peter Falkai; Konrad Beyreuther
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.
Neuroscience letters 1999;266(3):213-6.
1999: M Jensen; J Schröder; M Blomberg; Benita Engvall; J Pantel; N Ida; Hans Basun; Lars-Olof Wahlund; Egon Werle; Marek Jauss; Konrad Beyreuther; Lars Lannfelt; Tobias Hartmann
Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression.
Annals of neurology 1999;45(4):504-11.
1999: Tobias Hartmann
Intracellular biology of Alzheimer's disease amyloid beta peptide.
European archives of psychiatry and clinical neuroscience 1999;249(6):291-8.
1999: Imrich Blasko; Florentine Marx; E Steiner; Tobias Hartmann; Beatrix Grubeck-Loebenstein
TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):63-8.
1998: Janetta G Culvenor; A Henry; Tobias Hartmann; Geneviève Evin; Denise Galatis; Anna Friedhuber; U L Jayasena; JR Underwood; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(2):79-89.
1997: J Schröder; Johannes Pantel; N Ida; M Essig; Tobias Hartmann; M V Knopp; L R Schad; R Sandbrink; H Sauer; Colin L Masters; Konrad Beyreuther
Cerebral changes and cerebrospinal fluid beta-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging.
Molecular psychiatry 1997;2(6):505-7.
1997: Tobias Hartmann; S C Bieger; Barbara Brühl; P J Tienari; N Ida; D Allsop; G W Roberts; Colin L Masters; C G Dotti; Klaus Unsicker; Konrad Beyreuther
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.
Nature medicine 1997;3(9):1016-20.
1996: P J Tienari; Bart De Strooper; E Ikonen; M Simons; Andreas Weidemann; C Czech; Tobias Hartmann; N Ida; Gerd Multhaup; Colin L Masters; Fred Van Leuven; Konrad Beyreuther; Carlos G Dotti
The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.
The EMBO journal 1996;15(19):5218-29.
1996: N Ida; Tobias Hartmann; Johannes Pantel; Johannes Schröder; R Zerfass; hans förstl; R Sandbrink; Colin L Masters; Konrad Beyreuther
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.
The Journal of biological chemistry 1996;271(37):22908-14.
1996: Tobias Hartmann; C Bergsdorf; R Sandbrink; P J Tienari; Gerd Multhaup; N Ida; S Bieger; T Dyrks; Andreas Weidemann; Colin L Masters; Konrad Beyreuther
Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing.
The Journal of biological chemistry 1996;271(22):13208-14.
1996: R Sandbrink; Tobias Hartmann; Colin L Masters; Konrad Beyreuther
Genes contributing to Alzheimer's disease.
Molecular psychiatry 1996;1(1):27-40.
1994: hans förstl; C Czech; H Sattel; C Geiger-Kabisch; C Besthorn; Spencer Kreger; U Mönning; Tobias Hartmann; Colin L Masters; Konrad Beyreuther
[Apolipoprotein E and Alzheimer dementia. Personal results and brief literature review].
Der Nervenarzt 1994;65(11):780-6.
1993: C Czech; V Mönning; P J Tienari; Tobias Hartmann; Colin L Masters; Konrad Beyreuther; hans förstl
Apolipoprotein E-epsilon 4 allele and Alzheimer's disease.
Lancet 1993;342(8882):1309.
1992: T Dyrks; E Dyrks; Tobias Hartmann; Colin L Masters; Konrad Beyreuther
Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.
The Journal of biological chemistry 1992;267(25):18210-7.