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Shin-Shay Tian

Research Profile

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Robert Epple; Christopher Cow; Yongping Xie; Mihai Azimioara; Ross Russo; Xing Wang; John Wityak; Donald S Karanewsky; Tove tuntland; Vân T B Nguyêñ-Trân; Cara Cuc Ngo; David Huang; Enrique Saez; Tracy A Spalding; Andrea Gerken; Maya Iskandar; H Martin Seidel; Shin-Shay Tian
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.
Guobao Zhang; Pingda Ren; Nathanael S Gray; Taebo Sim; Xia Wang; Yi Liu; Jianwei Che; Weitong Dong; Shin-Shay Tian; Mark L Sandberg; Tracy A Spalding; Russell Romeo; Maya Iskandar; Zhiliang Wang; H Martin Seidel; Donald S Karanewsky; Yun He
Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.
Connie L Erickson-Miller; Evelyne Delorme; Shin-Shay Tian; Christopher B Hopson; Amy J Landis; Elizabeth I Valoret; Teresa S Sellers; Jon Rosen; Stephen G Miller; Juan I Luengo; Kevin J Duffy; Julian M Jenkins
Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist.

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All Publications

2010: Robert Epple; Christopher Cow; Yongping Xie; Mihai Azimioara; Ross Russo; Xing Wang; John Wityak; Donald S Karanewsky; Tove tuntland; Vân T B Nguyêñ-Trân; Cara Cuc Ngo; David Huang; Enrique Saez; Tracy A Spalding; Andrea Gerken; Maya Iskandar; H Martin Seidel; Shin-Shay Tian
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.
Journal of medicinal chemistry 2010;53(1):77-105.
2009: Guobao Zhang; Pingda Ren; Nathanael S Gray; Taebo Sim; Xia Wang; Yi Liu; Jianwei Che; Weitong Dong; Shin-Shay Tian; Mark L Sandberg; Tracy A Spalding; Russell Romeo; Maya Iskandar; Zhiliang Wang; H Martin Seidel; Donald S Karanewsky; Yun He
Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.
Bioorganic & medicinal chemistry letters 2009;19(23):6691-5.
2009: Connie L Erickson-Miller; Evelyne Delorme; Shin-Shay Tian; Christopher B Hopson; Amy J Landis; Elizabeth I Valoret; Teresa S Sellers; Jon Rosen; Stephen G Miller; Juan I Luengo; Kevin J Duffy; Julian M Jenkins
Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist.
Stem cells (Dayton, Ohio) 2009;27(2):424-30.
2008: Guobao Zhang; Pingda Ren; Nathanael S Gray; Taebo Sim; Yi Liu; Xia Wang; Jianwei Che; Shin-Shay Tian; Mark L Sandberg; Tracy A Spalding; Russell Romeo; Maya Iskandar; Donald Chow; H Martin Seidel; Donald S Karanewsky; Yun He
Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I.
Bioorganic & medicinal chemistry letters 2008;18(20):5618-21.
2008: Thomas H Marsilje; Phil B Alper; Wenshuo Lu; Daniel Mutnick; Pierre-Yves Michellys; Yun He; Donald S Karanewsky; Donald Chow; Andrea Gerken; Jianmin Lao; Min-Ju Kim; H Martin Seidel; Shin-Shay Tian
Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold.
Bioorganic & medicinal chemistry letters 2008;18(19):5259-62.
2008: Phil B Alper; Thomas H Marsilje; Daniel Mutnick; Wenshuo Lu; Arnab Chatterjee; Michael J Roberts; Yun He; Donald S Karanewsky; Donald Chow; Jianmin Lao; Andrea Gerken; Tove tuntland; Bo Liu; Jonathan Chang; Perry Gordon; H Martin Seidel; Shin-Shay Tian
Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.
Bioorganic & medicinal chemistry letters 2008;18(19):5255-8.
2008: Shenlin Huang; Zuosheng Liu; Shin-Shay Tian; Mark Sandberg; Tracy A Spalding; Russell Romeo; Maya Iskandar; Zhiliang Wang; Donald Karanewsky; Yun He
Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(7):2324-8.
2007: Min-Ju Kim; Sang Ho Park; Stanley J Opella; Thomas H Marsilje; Pierre-Yves Michellys; H Martin Seidel; Shin-Shay Tian
NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains.
The Journal of biological chemistry 2007;282(19):14253-61.
2006: Robert Epple; Mihai Azimioara; Ross Russo; Yongping Xie; Xing Wang; Christopher Cow; John Wityak; Donald S Karanewsky; Badry Bursulaya; Andreas Kreusch; Tove tuntland; Andrea Gerken; Maya Iskandar; Enrique Saez; H Martin Seidel; Shin-Shay Tian
3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.
Bioorganic & medicinal chemistry letters 2006;16(21):5488-92.
2006: Robert Epple; Ross Russo; Mihai Azimioara; Christopher Cow; Yongping Xie; Xing Wang; John Wityak; Donald S Karanewsky; Andrea Gerken; Maya Iskandar; Enrique Saez; H Martin Seidel; Shin-Shay Tian
3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1.
Bioorganic & medicinal chemistry letters 2006;16(16):4376-80.
2006: Robert Epple; Mihai Azimioara; Ross Russo; Badry Bursulaya; Shin-Shay Tian; Andrea Gerken; Maya Iskandar
1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.
Bioorganic & medicinal chemistry letters 2006;16(11):2969-73.
2005: Connie L Erickson-Miller; Evelyne Delorme; Shin-Shay Tian; Christopher B Hopson; Kenneth Stark; Leslie Giampa; Elizabeth I Valoret; Kevin J Duffy; Juan L Luengo; Jon Rosen; Stephen G Miller; Susan B Dillon; Peter Lamb
Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist.
Experimental hematology 2005;33(1):85-93.
2003: Michael Doyle; Shin-Shay Tian; Stephen G Miller; Linda Kessler; Audrey E Baker; Michael Brigham-Burke; Susan B Dillon; Kevin J Duffy; Richard M Keenan; Ruth Lehr; Jon Rosen; Lumelle Schneeweis; John Trill; Peter Young; Juan I Luengo; Peter Lamb
Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand.
The Journal of biological chemistry 2003;278(11):9426-34.
2001: Kevin J Duffy; Michael G Darcy; Evelyne Delorme; Susan B Dillon; D F Eppley; Connie L Erickson-Miller; Leslie Giampa; Christopher B Hopson; Yifang Huang; Richard M Keenan; Peter Lamb; L Leong; Nannan Liu; Stephen G Miller; Alan T Price; Jon Rosen; R Shah; T N Shaw; Heather Smith; K C Stark; Shin-Shay Tian; Curtis Tyree; Kenneth J Wiggall; Lihua Zhang; Juan I Luengo
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
Journal of medicinal chemistry 2001;44(22):3730-45.
1998: Shin-Shay Tian; Peter Lamb; Andrew G King; Stephen G Miller; L Kessler; Juan I Luengo; L Averill; R K Johnson; J G Gleason; Louis M Pelus; Susan B Dillon; Jon Rosen
A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor [see commetns].
Science (New York, N.Y.) 1998;281(5374):257-9.
1996: Shin-Shay Tian; P Tapley; C Sincich; R B Stein; J Rosen; P Lamb
Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes.
Blood 1996;88(12):4435-44.
1994: Shin-Shay Tian; Kai Zinn
An adhesion molecule-like protein that interacts with and is a substrate for a Drosophila receptor-linked protein tyrosine phosphatase.
The Journal of biological chemistry 1994;269(45):28478-86.
1994: Shin-Shay Tian; P Lamb; H M Seidel; R B Stein; J Rosen
Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor.
Blood 1994;84(6):1760-4.
1991: Shin-Shay Tian; Pantelis Tsoulfas; Kai Zinn
Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo.
Cell 1991;67(4):675-85.
1989: Shin-Shay Tian; C Faust
A simple and precise aberrant translocation of the rat c-myc gene into the epsilon-heavy chain switch region of the IgE-producing immunocytoma, IR162.
The Journal of biological chemistry 1989;264(3):1846-53.
1987: Shin-Shay Tian; C Faust
Rearrangement of rat immunoglobulin E heavy-chain and c-myc genes in the B-cell immunocytoma IR162.
Molecular and cellular biology 1987;7(7):2614-9.
1984: M C Tzeng; Shin-Shay Tian
beta-Bungarotoxin antagonizes the effect of alpha-latrotoxin from black widow spider venom on the neuromuscular junction.
Journal of neurobiology 1984;15(2):157-60.
1983: M C Tzeng; Shin-Shay Tian
Use of chick biventer cervicis muscle in the bioassay of alpha-latrotoxin from black widow spider venom.
Toxicon : official journal of the International Society on Toxinology 1983;21(6):879-81.