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Marc Symons

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Physiology

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Olga Korkina; Allison Marullo; Marc Symons; Gregg Warshaw; Zhiwan Dong; Rosamaria Ruggieri
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
Aneta Kwiatkowska; Marc Symons
Signaling determinants of glioma cell invasion.
Yayu Chuang; Dan Flynn; Hyonson Hwang; Aneta Kwiatkowska; Konstantinos Petritis; George Tsapraillis; Xiaonan Xu; Marc Symons
Regulation of synaptojanin 2 5'-phosphatase activity by Src.

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All Publications

2013: Olga Korkina; Allison Marullo; Marc Symons; Gregg Warshaw; Zhiwan Dong; Rosamaria Ruggieri
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
The Journal of biological chemistry 2013;288(8):5364-73.
2013: Aneta Kwiatkowska; Marc Symons
Signaling determinants of glioma cell invasion.
Advances in experimental medicine and biology 2013;986():121-41.
2012: Yayu Chuang; Dan Flynn; Hyonson Hwang; Aneta Kwiatkowska; Konstantinos Petritis; George Tsapraillis; Xiaonan Xu; Marc Symons
Regulation of synaptojanin 2 5'-phosphatase activity by Src.
Cell adhesion & migration 2012;6(6):518-25.
2012: Issai Vanan; Gregg Warshaw; Zhiwan Dong; Marc Symons; Elena Tosti; Rosamaria Ruggieri
Role of a DNA damage checkpoint pathway in ionizing radiation-induced glioblastoma cell migration and invasion.
Cellular and molecular neurobiology 2012;32(7):1199-208.
2012: Aneta Kwiatkowska; Elisabeth Rushing; Nhan L Tran; Timothy White; Michael E Berens; Amanda Chan; Yayu Chuang; Sebastien Didier; Jennifer Eschbacher; Shannon Fortin; Marc Symons
The small GTPase RhoG mediates glioblastoma cell invasion.
Molecular cancer 2012;11():65.
2011: Marc Symons
Rac1 activation comes full circle.
The EMBO journal 2011;30(19):3875-7.
2010: Rong Wu; Allan Abramson; Marc Symons; Bettie Steinberg
Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.
International journal of cancer. Journal international du cancer 2010;127(9):2230-7.
2009: Salvatore Zavarella; Mitsutoshi Nakada; Shawn Belverud; Salvatore J Coniglio; Amanda Chan; Mark A Mittler; Steven J Schneider; Marc Symons
Role of Rac1-regulated signaling in medulloblastoma invasion. Laboratory investigation.
Journal of neurosurgery. Pediatrics 2009;4(2):97-104.
2009: Marc Symons; Jeffrey E Segall
Rac and Rho driving tumor invasion: who's at the wheel?
Genome biology 2009;10(3):213.
2008: Bodour Salhia; Nhan L Tran; Amanda Chan; Amparo Wolf; Mitsutoshi Nakada; Fiona Rutka; Matthew Ennis; Wendy S McDonough; Michael Berens; Marc Symons; James T Rutka
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
The American journal of pathology 2008;173(6):1828-38.
2008: Marc Symons
Cell biology: watching the first steps of podosome formation.
Current biology : CB 2008;18(19):R925-7.
2008: teresina laragione; Max Brenner; Adriana Mello; Marc Symons; Pércio S Gulko
The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts.
Arthritis and rheumatism 2008;58(8):2296-306.
2008: Salvatore J Coniglio; Salvatore Zavarella; Marc Symons
Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.
Molecular and cellular biology 2008;28(12):4162-72.
2008: Mirvat El-Sibai; Olivier Pertz; Huan Pang; Shu-Chin Yip; Mike Lorenz; Marc Symons; John Condeelis; Klaus M Hahn; Jonathan M Backer
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.
Experimental cell research 2008;314(7):1540-52.
2008: Bodour Salhia; Jeong Hyun Hwang; Christian A Smith; Mitsutoshi Nakada; Fiona Rutka; Marc Symons; James T Rutka
Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas.
Cell motility and the cytoskeleton 2008;65(1):12-24.
2007: Shu-Chin Yip; Mirvat El-Sibai; Salvatore J Coniglio; Ghassan mouneimne; Robert Eddy; Beth E Drees; Paul O Neilsen; Sumanta Goswami; Marc Symons; John Condeelis; Jonathan M Backer
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.
Journal of cell science 2007;120(Pt 17):3138-46.
2007: Ya-yu Chuang; Aline Valster; Salvatore J Coniglio; Jonathan M Backer; Marc Symons
The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration.
Journal of cell science 2007;120(Pt 11):1927-34.
2007: Amanda Chan; Mumtaz Akhtar; Max Brenner; Yi Zheng; Percio S Gulko; Marc Symons
The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.
Molecular medicine (Cambridge, Mass.) 2007;13(5-6):297-304.
2007: Rong Wu; Salvatore J Coniglio; Amanda Chan; Marc Symons; Bettie Steinberg
Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas.
Molecular medicine (Cambridge, Mass.) 2007;13(3-4):143-50.
2006: Nhan L Tran; Wendy S McDonough; Benjamin A Savitch; Shannon P Fortin; Jeffrey A Winkles; Marc Symons; Mitsutoshi Nakada; Heather Cunliffe; Galen Hostetter; Dominique Hoelzinger; Jessica L Rennert; Jennifer S Michaelson; Linda C Burkly; Christopher A Lipinski; Joseph C Loftus; Luigi Mariani; Michael Berens
Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.
Cancer research 2006;66(19):9535-42.
2006: Bodour Salhia; Nhan L Tran; Marc Symons; Jeffrey A Winkles; James T Rutka; Michael Berens
Molecular pathways triggering glioma cell invasion.
Expert review of molecular diagnostics 2006;6(4):613-26.
2005: Amanda Y Chan; Salvatore J Coniglio; Ya-yu Chuang; David Michaelson; Ulla G Knaus; Mark R Philips; Marc Symons
Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.
Oncogene 2005;24(53):7821-9.
2005: Aline Valster; Nhan L Tran; Mitsutoshi Nakada; Michael Berens; Amanda Y Chan; Marc Symons
Cell migration and invasion assays.
Methods (San Diego, Calif.) 2005;37(2):208-15.
2005: Paola Di Marzio; Wei Wei Dai; Giovanni Franchin; Amanda Y Chan; Marc Symons; Barbara Sherry
Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages.
Biochemical and biophysical research communications 2005;331(4):909-16.
2005: James D Swant; Beatriz E Rendon; Marc Symons; Robert A Mitchell
Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1.
The Journal of biological chemistry 2005;280(24):23066-72.
2005: Saijun Fan; Min Gao; Qinghui Meng; John Laterra; Marc Symons; Sal Coniglio; Richard G Pestell; Itzhak D Goldberg; Eliot M Rosen
Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection.
Oncogene 2005;24(10):1749-66.
2005: Hideki Yamaguchi; Mike Lorenz; Stephan J Kempiak; Corina Sarmiento; Salvatore J Coniglio; Marc Symons; Jeffrey E Segall; Robert Eddy; Hiroaki Miki; Tadaomi Takenawa; John Condeelis
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.
The Journal of cell biology 2005;168(3):441-52.
2004: Ya-yu Chuang; Nhan L Tran; Nicole Rusk; Mitsutoshi Nakada; Michael Berens; Marc Symons
Role of synaptojanin 2 in glioma cell migration and invasion.
Cancer research 2004;64(22):8271-5.
2004: Tzu-Ling Cheng; Marc Symons; Tzuu-Shuh Jou
Regulation of anoikis by Cdc42 and Rac1.
Experimental cell research 2004;295(2):497-511.
2004: Antoine E Karnoub; Marc Symons; Sharon L Campbell; Channing J Der
Molecular basis for Rho GTPase signaling specificity.
Breast cancer research and treatment 2004;84(1):61-71.
2004: Günther Schlunck; Hanna Damke; William B Kiosses; Nicole Rusk; Marc Symons; Clare M Waterman-Storer; Sandra L Schmid; Martin A Schwartz
Modulation of Rac localization and function by dynamin.
Molecular biology of the cell 2004;15(1):256-67.
2003: Xueke You; Hsiao-Man Yu; Leona Cohen-Gould; Brian Cao; Marc Symons; George Vande Woude; Beatrice S Knudsen
Regulation of migration of primary prostate epithelial cells by secreted factors from prostate stromal cells.
Experimental cell research 2003;288(2):246-56.
2003: Marc Symons; Nicole Rusk
Control of vesicular trafficking by Rho GTPases.
Current biology : CB 2003;13(10):R409-18.
2003: Peter Neumeister; Fiona J Pixley; Ying Xiong; Huafeng Xie; Kongming Wu; Anthony Ashton; Michael Cammer; Amanda Chan; Marc Symons; E Richard Stanley; Richard G Pestell
Cyclin D1 governs adhesion and motility of macrophages.
Molecular biology of the cell 2003;14(5):2005-15.
2003: Nicole Rusk; Phuong U Le; Stefania Mariggio; Ginette Guay; Cristiano Lurisci; Ivan R Nabi; Daniela Corda; Marc Symons
Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis.
Current biology : CB 2003;13(8):659-63.
2002: Linda Van Aelst; Marc Symons
Role of Rho family GTPases in epithelial morphogenesis.
Genes & development 2002;16(9):1032-54.
2002: Alessandra Giodini; Marko J Kallio; Nathan Wall; Gary J Gorbsky; Simona Tognin; Pier Carlo Marchisio; Marc Symons; Dario C Altieri
Regulation of microtubule stability and mitotic progression by survivin.
Cancer research 2002;62(9):2462-7.
2002: Jacqueline Banyard; Marc Symons
Cell motility and invasion assays.
Methods in molecular biology (Clifton, N.J.) 2002;189():129-40.
2001: Boumediene Bouzahzah; Chris Albanese; F Ahmed; Fiona J Pixley; Michael P Lisanti; Jeffrey E Segall; John Condeelis; D Joyce; Audrey Minden; Channing J Der; A Chan; Marc Symons; Richard G Pestell
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Molecular medicine (Cambridge, Mass.) 2001;7(12):816-30.
2001: Salvatore J Coniglio; Tzuu-Shuh Jou; Marc Symons
Rac1 protects epithelial cells against anoikis.
The Journal of biological chemistry 2001;276(30):28113-20.
2001: Rosamaria Ruggieri; Ya-yu Chuang; Marc Symons
The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts.
Molecular medicine (Cambridge, Mass.) 2001;7(5):293-300.
2001: C B Martin; Gwendolyn Mahon; Mark B Klinger; Robert J Kay; Marc Symons; Channing J Der; Ian P Whitehead
The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.
Oncogene 2001;20(16):1953-63.
2001: Marc Symons; Y Takai
Ras GTPases: singing in tune.
Science's STKE : signal transduction knowledge environment 2001;2001(68):pe1.
2001: Y J Choi; M Niedbala; M Lynch; Marc Symons; Gideon Bollag; A K North
Assays of human postprenylation processing enzymes.
Methods in enzymology 2001;332():103-14.
2000: N Malecz; P C McCabe; C Spaargaren; R Qiu; Y Chuang; Marc Symons
Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis.
Current biology : CB 2000;10(21):1383-6.
2000: Marc Symons; J Settleman
Rho family GTPases: more than simple switches.
Trends in cell biology 2000;10(10):415-9.
2000: A M Crompton; L H Foley; A Wood; W Roscoe; David Stokoe; Frank McCormick; Marc Symons; Gideon Bollag
Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands.
The Journal of biological chemistry 2000;275(33):25751-9.
2000: I E Zohn; Mark B Klinger; X Karp; HE Kirk; Marc Symons; Magdalena Wodnicka; Channing J Der; Robert J Kay
G2A is an oncogenic G protein-coupled receptor.
Oncogene 2000;19(34):3866-77.
2000: Marc Symons
Adhesion signaling: PAK meets Rac on solid ground.
Current biology : CB 2000;10(14):R535-7.
2000: Jacqueline Banyard; Bela Anand-Apte; Marc Symons; Bruce R Zetter
Motility and invasion are differentially modulated by Rho family GTPases.
Oncogene 2000;19(4):580-91.
2000: Gideon Bollag; A M Crompton; D Peverly-Mitchell; Gaston Habets; Marc Symons
Activation of Rac1 by human Tiam1.
Methods in enzymology 2000;325():51-61.
1998: Angeliki Malliri; Marc Symons; Robert F Hennigan; Adam F L Hurlstone; RF Lamb; T Wheeler; Bradford W Ozanne
The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells.
The Journal of cell biology 1998;143(4):1087-99.
1998: E A Clark; WG King; Joan S Brugge; Marc Symons; Richard O Hynes
Integrin-mediated signals regulated by members of the rho family of GTPases.
The Journal of cell biology 1998;142(2):573-86.
1998: JK Westwick; R J Lee; QT Lambert; Marc Symons; R G Pestell; Channing J Der; Ian P Whitehead
Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun.
The Journal of biological chemistry 1998;273(27):16739-47.
1998: Farrah Kheradmand; E Werner; P Tremble; Marc Symons; Zena Werb
Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change.
Science (New York, N.Y.) 1998;280(5365):898-902.
1998: I E Zohn; Marc Symons; Magdalena Wodnicka; JK Westwick; Channing J Der
Mas oncogene signaling and transformation require the small GTP-binding protein Rac.
Molecular and cellular biology 1998;18(3):1225-35.
1997: Bela Anand-Apte; Bruce R Zetter; A Viswanathan; R G Qiu; J Chen; Rosamaria Ruggieri; Marc Symons
Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways.
The Journal of biological chemistry 1997;272(49):30688-92.
1997: R G Qiu; A Abo; F McCormick; Marc Symons
Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation.
Molecular and cellular biology 1997;17(6):3449-58.
1997: Marco Falasca; A Carvelli; Cristiano Iurisci; R G Qiu; Marc Symons; Daniela Corda
Fast receptor-induced formation of glycerophosphoinositol-4-phosphate, a putative novel intracellular messenger in the Ras pathway.
Molecular biology of the cell 1997;8(3):443-53.
1997: JK Westwick; QT Lambert; Geoffrey J Clark; Marc Symons; Linda Van Aelst; R G Pestell; Channing J Der
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.
Molecular and cellular biology 1997;17(3):1324-35.
1997: JA Hess; A H Ross; R G Qiu; Marc Symons; John H Exton
Role of Rho family proteins in phospholipase D activation by growth factors.
The Journal of biological chemistry 1997;272(3):1615-20.
1996: Zinaida S Vexler; Marc Symons; Diane L Barber
Activation of Na+-H+ exchange is necessary for RhoA-induced stress fiber formation.
The Journal of biological chemistry 1996;271(37):22281-4.
1996: Marc Symons
Rho family GTPases: the cytoskeleton and beyond.
Trends in biochemical sciences 1996;21(5):178-81.
1996: Maikel Peppelenbosch; Leon Tertoolen; Alida M M de Vries-Smits; R G Qiu; L M'Rabet; Marc Symons; SW De Laat; Johannes L Bos
Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.
The Journal of biological chemistry 1996;271(14):7883-6.
1996: R Hooley; C Y Yu; Marc Symons; Diane L Barber
G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways.
The Journal of biological chemistry 1996;271(11):6152-8.
1996: Marc Symons; J M Derry; B Karlak; S Jiang; V Lemahieu; F Mccormick; Uta Francke; A Abo
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Cell 1996;84(5):723-34.
1995: R G Qiu; J Chen; F McCormick; Marc Symons
A role for Rho in Ras transformation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11781-5.
1995: Marc Symons
The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies.
Current opinion in biotechnology 1995;6(6):668-74.
1995: J Marcusohn; Steven J Isakoff; E Rose; Marc Symons; Edward Y Skolnik
The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes.
Current biology : CB 1995;5(11):1296-302.
1995: Maikel Peppelenbosch; R G Qiu; Alida M M de Vries-Smits; Leon Tertoolen; SW De Laat; F McCormick; Alan Hall; Marc Symons; Johannes L Bos
Rac mediates growth factor-induced arachidonic acid release.
Cell 1995;81(6):849-56.
1995: A R Siddiqi; J L Smith; A H Ross; R G Qiu; Marc Symons; John H Exton
Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D.
The Journal of biological chemistry 1995;270(15):8466-73.
1995: Phillip T Hawkins; Alicia Eguinoa; R G Qiu; David Stokoe; F T Cooke; R Walters; S Wennström; Lena Claesson-Welsh; T Evans; Marc Symons
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase.
Current biology : CB 1995;5(4):393-403.
1995: R G Qiu; J Chen; David H Kirn; F McCormick; Marc Symons
An essential role for Rac in Ras transformation.
Nature 1995;374(6521):457-9.
1994: K C Malcolm; A H Ross; R G Qiu; Marc Symons; John H Exton
Activation of rat liver phospholipase D by the small GTP-binding protein RhoA.
The Journal of biological chemistry 1994;269(42):25951-4.
1994: E Freed; Marc Symons; S G Macdonald; F McCormick; Rosamaria Ruggieri
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation.
Science (New York, N.Y.) 1994;265(5179):1713-6.
1994: David Stokoe; S G Macdonald; K Cadwallader; Marc Symons; J F Hancock
Activation of Raf as a result of recruitment to the plasma membrane.
Science (New York, N.Y.) 1994;264(5164):1463-7.
1992: Marc Symons; Timothy J Mitchison
A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts.
The Journal of cell biology 1992;118(5):1235-44.
1991: Marc Symons; Timothy J Mitchison
Control of actin polymerization in live and permeabilized fibroblasts.
The Journal of cell biology 1991;114(3):503-13.