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Paul Carlier
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14
Pang, Yuan-Ping
12
Han, Yi-Fan
6
Lee, Nelson
5
Han, Yifan
5
Wong, Dawn
4
Wang, Hui
4
Pang, Yuanping
4
Lam, Polo C-H
3
Richelson, Elliott
3
Silman, Israel
3
Sussman, Joel
3
Xue, Hong
3
Chow, Ella S-H
3
Greenblatt, Harry
3
Kan, Kelvin
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All Publications
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2009: Yu Hua; Li Wen Ming; Cheung Man Chun; Zuo Zhong; Carlier Paul R; Gu Ze Ming; Chan Kelvin; Huang Min; Wang Yi Tao; Han Yi Fan
Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis 2009;49(2):410-4.
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2008: Liang Yanqi; Shaw Amanda M; Boules Mona; Briody Siobhan; Robinson Jessica; Oliveros Alfredo; Blazar Eric; Williams Katrina; Zhang Yiqun; Carlier Paul R; Richelson Elliott
Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS).
The Journal of pharmacology and experimental therapeutics 2008;327(2):573-83.
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2008: Carlier Paul R; Anderson Troy D; Wong Dawn M; Hsu Danny C; Hartsel Joshua; Ma Ming; Wong Eric A; Choudhury Ranginee; Lam Polo C-H; Totrov Maxim M; Bloomquist Jeffrey R
Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae.
Chemico-biological interactions 2008;175(1-3):368-75.
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2008: Yu Hua; Li Wen-Ming; Kan Kelvin K W; Ho Jason M K; Carlier Paul R; Pang Yuan-Ping; Gu Zhe-Ming; Zhong Zuo; Chan Kelvin; Wang Yi-Tao; Han Yi-Fan
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.
Journal of pharmaceutical and biomedical analysis 2008;46(1):75-81.
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2007: Li W M; Kan K K W; Carlier P R; Pang Y P; Han Y F
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Current Alzheimer research 2007;4(4):386-96.
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2007: Carlier Paul R; Zhang Yiqun
The first enantioenriched metalated nitrile possessing macroscopic configurational stability.
Organic letters 2007;9(7):1319-22.
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2007: Li Chaoying; Carlier Paul R; Ren Hong; Kan Kelvin K W; Hui Kwokmin; Wang Hong; Li Wenming; Li Zhiwang; Xiong Keming; Clement Ella Chow; Xue Hong; Liu Xiangou; Li Mingtao; Pang Yuanping; Han Yifan
Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers.
Neuropharmacology 2007;52(2):436-43.
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2007: Shaw Amanda M; Boules Mona; Zhang Yiqun; Williams Katrina; Robinson Jessica; Carlier Paul R; Richelson Elliott
Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.
European journal of pharmacology 2007;555(1):30-6.
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2006: Carlier Paul R; Zhao Hongwu; MacQuarrie-Hunter Stephanie L; DeGuzman Joseph C; Hsu Danny C
Enantioselective synthesis of diversely substituted quaternary 1,4-benzodiazepin-2-ones and 1,4-benzodiazepine-2,5-diones.
Journal of the American Chemical Society 2006;128(47):15215-20.
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2006: Carlier Paul R; Zhang Yiqun; Slebodnick Carla; Lo Michael M-C; Williams Ian D
Effect of 2,6-disubstituted aryl groups on acyclic conformation: preference for an antiperiplanar orientation of the geminal and vicinal hydrogens.
The Journal of organic chemistry 2006;71(23):8835-41.
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2006: Rydberg Edwin H; Brumshtein Boris; Greenblatt Harry M; Wong Dawn M; Shaya David; Williams Larry D; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Journal of medicinal chemistry 2006;49(18):5491-500.
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2006: Carlier Paul R; Deora Nipa; Crawford T Daniel
Protonated 2-methyl-1,2-epoxypropane: a challenging problem for density functional theory.
The Journal of organic chemistry 2006;71(4):1592-7.
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2005: MacQuarrie-Hunter Stephanie; Carlier Paul R
Highly enantioselective synthesis of rigid, quaternary 1,4-benzodiazepine-2,5-diones derived from proline.
Organic letters 2005;7(23):5305-8.
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2005: Haviv Haim; Wong Dawn M; Greenblatt Harry M; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.
Journal of the American Chemical Society 2005;127(31):11029-36.
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2005: Li Wenming; Pi Rongbiao; Chan Hugh H N; Fu Hongjun; Lee Nelson T K; Tsang Hing Wai; Pu Yongmei; Chang Donald C; Li Chaoying; Luo Jialie; Xiong Keming; Li Zhiwang; Xue Hong; Carlier Paul R; Pang Yuanping; Tsim Karl W K; Li Mingtao; Han Yifan
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
The Journal of biological chemistry 2005;280(18):18179-88.
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2005: Lam Polo C-H; Carlier Paul R
Experimental and computational studies of ring inversion of 1,4-benzodiazepin-2-ones: implications for memory of chirality transformations.
The Journal of organic chemistry 2005;70(5):1530-8.
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2004: Carlier Paul R
Threading the needle: mimicking natural toroidal catalysts.
Angewandte Chemie (International ed. in English) 2004;43(20):2602-5.
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2004: Du Da-Ming; Carlier Paul R
Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.
Current pharmaceutical design 2004;10(25):3141-56.
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2003: Carlier Paul R; Zhao Hongwu; DeGuzman Joe; Lam Polo C-H
Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality.
Journal of the American Chemical Society 2003;125(38):11482-3.
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2003: Carlier Paul R
Configurational stability of chiral lithiated cyclopropylnitriles: a density functional study.
Chirality 2003;15(4):340-7.
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2003: Wong Dawn M; Greenblatt Harry M; Dvir Hay; Carlier Paul R; Han Yi-Fan; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
Journal of the American Chemical Society 2003;125(2):363-73.
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2002: Jang Chang-Hyun; Stevens Benjamin D; Carlier Paul R; Calter Michael A; Ducker William A
Immobilized enzymes as catalytically-active tools for nanofabrication.
Journal of the American Chemical Society 2002;124(41):12114-5.
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2002: Carlier Paul R; Lam Polo C-H; Wong Dawn M
Catalytic asymmetric synthesis of protected tryptophan regioisomers.
The Journal of organic chemistry 2002;67(17):6256-9.
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2002: Carlier Paul R; Chow Ella S-H; Barlow Rebecca L; Bloomquist Jeffrey R
Discovery of non-zwitterionic GABA(A) receptor full agonists and a superagonist.
Bioorganic & medicinal chemistry letters 2002;12(15):1985-8.
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2002: Carlier Paul R; Madura Jeffry D
Effective computational modeling of constitutional isomerism and aggregation states of explicit solvates of lithiated phenylacetonitrile.
The Journal of organic chemistry 2002;67(11):3832-40.
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2002: Lewis Warren G; Green Luke G; Grynszpan Flavio; Radic Zoran; Carlier Paul R; Taylor Palmer; Finn M G; Sharpless K Barry
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.
Angewandte Chemie (International ed. in English) 2002;41(6):1053-7.
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2002: Pan S Y; Han Y F; Carlier P R; Pang Y P; Mak D H F; Lam B Y H; Ko K M
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.
Planta medica 2002;68(3):217-20.
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2000: Xiao X Q; Lee N T; Carlier P R; Pang Y; Han Y F
Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine.
Neuroscience letters 2000;290(3):197-200.
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2000: Wu D C; Xiao X Q; Ng A K; Chen P M; Chung W; Lee N T; Carlier P R; Pang Y P; Yu A C; Han Y F;
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].
Neuroscience letters 2000;288(2):95-8.
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2000: Liu J; Ho W; Lee N T; Carlier P R; Pang Y; Han Y
Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats.
Neuroscience letters 2000;282(3):165-8.
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2000: Lenigk R; Lam E; Lai A; Wang H; Han Y; Carlier P; Renneberg R
Enzyme biosensor for studying therapeutics of Alzheimer's disease.
Biosensors & bioelectronics 2000;15(9-10):541-7.
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1999: Han Y F; Li C P; Chow E; Wang H; Pang Y P; Carlier P R
Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.
Bioorganic & medicinal chemistry 1999;7(11):2569-75.
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1999: Carlier P R; Chow E S; Han Y; Liu J; El Yazal J; Pang Y P
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.
Journal of medicinal chemistry 1999;42(20):4225-31.
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1999: Carlier P R; Du D M; Han Y; Liu J; Pang Y P
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(16):2335-8.
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1999: Wang H; Carlier P R; Ho W L; Lee N T; Pang Y P; Han Y F
Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(3):211-7.
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1999: Li C Y; Wang H; Xue H; Carlier P R; Hui K M; Pang Y P; Li Z W; Han Y F
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist.
Neuroreport 1999;10(4):795-800.
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1999: Wang H; Carlier P R; Ho W L; Wu D C; Lee N T; Li C P; Pang Y P; Han Y F
Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE.
Neuroreport 1999;10(4):789-93.
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1999: Carlier P R; Han Y F; Chow E S; Li C P; Wang H; Lieu T X; Wong H S; Pang Y P
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.
Bioorganic & medicinal chemistry 1999;7(2):351-7.
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1998: Carlier P R; Lo M M; Lo P C; Richelson E; Tatsumi M; Reynolds I J; Sharma T A
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.
Bioorganic & medicinal chemistry letters 1998;8(5):487-92.
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