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David Carling

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Angela Woods; James M Leiper; David Carling
The role of ATM in response to metformin treatment and activation of AMPK.
Yugo Tsuchiya; David Carling; Fiona C Denison; Richard B Heath; David Saggerson
5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.
Faith V Mayer; Rhonda R McCartney; Roksana Ogrodowicz; Matthew J Sanders; Martin C Schmidt; Elizabeth Underwood; Philip A Walker; Bing Xiao; David Carmena; Steven J Gamblin; Lesley F Haire; Richard Heath; Chun Jing; Fiona C Leiper; Stephen R Martin; David Carling
ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.

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All Publications

2012: Angela Woods; James M Leiper; David Carling
The role of ATM in response to metformin treatment and activation of AMPK.
Nature genetics 2012;44(4):360-1.
2012: Yugo Tsuchiya; David Carling; Fiona C Denison; Richard B Heath; David Saggerson
5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.
Bioscience reports 2012;32(2):197-213.
2011: Faith V Mayer; Rhonda R McCartney; Roksana Ogrodowicz; Matthew J Sanders; Martin C Schmidt; Elizabeth Underwood; Philip A Walker; Bing Xiao; David Carmena; Steven J Gamblin; Lesley F Haire; Richard Heath; Chun Jing; Fiona C Leiper; Stephen R Martin; David Carling
ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.
Cell metabolism 2011;14(5):707-14.
2011: D Grahame Hardie; David Carling; Steven J Gamblin
AMP-activated protein kinase: also regulated by ADP?
Trends in biochemical sciences 2011;36(9):470-7.
2011: Bing Xiao; Matthew J Sanders; Elizabeth Underwood; Richard Heath; Faith V Mayer; David Carmena; Chun Jing; Philip A Walker; John F Eccleston; Lesley F Haire; Peter Saiu; Steven A Howell; Rein Aasland; Stephen Martin; David Carling; Steven J Gamblin
Structure of mammalian AMPK and its regulation by ADP.
Nature 2011;472(7342):230-3.
2011: Claire Thornton; Nicola J Bright; Magdalena Sastre; Phillip J Muckett; David Carling
AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.
The Biochemical journal 2011;434(3):503-12.
2011: Marc Claret; Mark A Smith; Claude Knauf; Hind Al-Qassab; Angela Woods; Amanda Heslegrave; Kaisa Piipari; Julian J Emmanuel; André Colom; Philippe Valet; Patrice D Cani; Ghazala Begum; Anne White; Phillip Mucket; Marco Peters; Keiko Mizuno; Rachel L Batterham; peter giese; Alan Ashworth; Remy Burcelin; Michael L Ashford; David Carling; Dominic J Withers
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.
Diabetes 2011;60(3):735-45.
2011: Angela Woods; Amanda J Heslegrave; Phillip J Muckett; Adam P Levene; Melanie Clements; Margaret Mobberley; Timothy A Ryder; Shadi Abu-Hayyeh; Catherine Williamson; Robert D Goldin; Alan Ashworth; Dominic J Withers; David Carling
LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice.
The Biochemical journal 2011;434(1):49-60.
2010: Craig Beall; Kaisa Piipari; Hind Al-Qassab; Mark A Smith; Nadeene Parker; David Carling; Benoit Viollet; Dominic J Withers; Michael L J Ashford
Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.
The Biochemical journal 2010;429(2):323-33.
2009: Colin Selman; Jennifer M A Tullet; Daniela Wieser; Elaine Irvine; Steven J Lingard; Agharul I Choudhury; Marc Claret; Hind Al-Qassab; Danielle Carmignac; Faruk Ramadani; Angela Woods; Iain C A Robinson; Eugene Schuster; Rachel L Batterham; Sara C Kozma; George Thomas; David Carling; Klaus Okkenhaug; Janet M Thornton; Linda Partridge; David Gems; Dominic J Withers
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Science (New York, N.Y.) 2009;326(5949):140-4.
2009: N J Bright; C Thornton; David Carling
The regulation and function of mammalian AMPK-related kinases.
Acta physiologica (Oxford, England) 2009;196(1):15-26.
2009: David Carling
Branching out on AMPK Regulation.
Cell metabolism 2009;9(1):7-8.
2009: Fiona C Denison; Natalie J Hiscock; David Carling; Angela Woods
Characterization of an alternative splice variant of LKB1.
The Journal of biological chemistry 2009;284(1):67-76.
2008: David Carling; M J Sanders; Angela Woods
The regulation of AMP-activated protein kinase by upstream kinases.
International journal of obesity (2005) 2008;32 Suppl 4():S55-9.
2007: Matthew J Sanders; Zahabia S Ali; Bronwyn D Hegarty; Richard Heath; Michael A Snowden; David Carling
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.
The Journal of biological chemistry 2007;282(45):32539-48.
2007: Patricia K Dranchak; Fiona C Leiper; Stephanie J Valberg; Richard J Piercy; David Carling; Molly E McCue; James R Mickelson
Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses.
American journal of veterinary research 2007;68(10):1079-84.
2007: Bing Xiao; Richard Heath; Peter Saiu; Fiona C Leiper; Philippe Leone; Chun Jing; Philip A Walker; Lesley F Haire; John F Eccleston; Colin T Davis; Stephen Martin; David Carling; Steven J Gamblin
Structural basis for AMP binding to mammalian AMP-activated protein kinase.
Nature 2007;449(7161):496-500.
2007: Marc Claret; Mark A Smith; Rachel L Batterham; Colin Selman; Agharul I Choudhury; Lee G D Fryer; Melanie Clements; Hind Al-Qassab; Helen Heffron; Allison W Xu; John R Speakman; Gregory S Barsh; Benoit Viollet; Sophie Vaulont; Michael L J Ashford; David Carling; Dominic J Withers
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.
The Journal of clinical investigation 2007;117(8):2325-36.
2007: Victor Aguilar; Samira Alliouachene; Athanassia Sotiropoulos; Andrew K Sobering; Yoni Athea; Fatima Djouadi; Sylvain miraux; Eric Thiaudière; Marc Foretz; Benoit Viollet; Philippe Diolez; Jean Bastin; Paule Benit; Pierre Rustin; David Carling; Marco Sandri; Renée Ventura-Clapier; Mario Pende
S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.
Cell metabolism 2007;5(6):476-87.
2007: Matthew J Sanders; Pascal O Grondin; Bronwyn D Hegarty; Michael A Snowden; David Carling
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade.
The Biochemical journal 2007;403(1):139-48.
2007: David Carling
The role of the AMP-activated protein kinase in the regulation of energy homeostasis.
Novartis Foundation symposium 2007;286():72-81; discussion 81-5, 162-3, 196-203.
2006: Joanna K Davies; Dominic J Wells; Ke Liu; Helen R Whitrow; Tyrone D Daniel; Robert Grignani; Craig A Lygate; Jürgen E Schneider; Gaëtane Noël; Hugh Watkins; David Carling
Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.
American journal of physiology. Heart and circulatory physiology 2006;290(5):H1942-51.
2006: David Carling
LKB1: a sweet side to Peutz-Jeghers syndrome?
Trends in molecular medicine 2006;12(4):144-7.
2006: Sandrine Horman; Didier Vertommen; Richard Heath; Dietbert Neumann; Véronique Mouton; Angela Woods; Uwe Schlattner; Theo Wallimann; David Carling; Louis Hue; Mark H Rider
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.
The Journal of biological chemistry 2006;281(9):5335-40.
2005: Angela Woods; Kristina Dickerson; Richard Heath; Seung-Pyo Hong; Milica Momcilovic; Stephen R Johnstone; Marian Carlson; David Carling
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.
Cell metabolism 2005;2(1):21-33.
2005: Ulrika Andersson; Jonas T Treebak; Jakob N Nielsen; Kirsty L Smith; Caroline R Abbott; Caroline J Small; David Carling; Erik A Richter
Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity.
Biochemical and biophysical research communications 2005;329(2):719-25.
2005: Lee G D Fryer; David Carling
AMP-activated protein kinase and the metabolic syndrome.
Biochemical Society transactions 2005;33(Pt 2):362-6.
2005: Barbara B Kahn; Thierry Alquier; David Carling; D Grahame Hardie
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Cell metabolism 2005;1(1):15-25.
2005: David Carling
AMP-activated protein kinase: balancing the scales.
Biochimie 2005;87(1):87-91.
2004: Hilary Clark; David Carling; David Saggerson
Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids.
European journal of biochemistry / FEBS 2004;271(11):2215-24.
2004: Susan W Y Cheng; Lee G D Fryer; David Carling; Peter R Shepherd
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.
The Journal of biological chemistry 2004;279(16):15719-22.
2004: Ulrika Andersson; Karin Filipsson; Caroline R Abbott; Angela Woods; Kirsty Smith; Stephen R Bloom; David Carling; Caroline J Small
AMP-activated protein kinase plays a role in the control of food intake.
The Journal of biological chemistry 2004;279(13):12005-8.
2004: Carles Cantó; Elisabeth Suárez; Jose Lizcano; Elisenda Griñó; Peter R Shepherd; Lee G D Fryer; David Carling; Joan Bertran; Manuel Palacín; Antonio Zorzano; Anna Gumà
Neuregulin signaling on glucose transport in muscle cells.
The Journal of biological chemistry 2004;279(13):12260-8.
2004: David Carling
AMPK.
Current biology : CB 2004;14(6):R220.
2004: David Carling
The AMP-activated protein kinase cascade--a unifying system for energy control.
Trends in biochemical sciences 2004;29(1):18-24.
2003: David Carling; Lee G D Fryer; Angela Woods; Tyrone Daniel; S L C Jarvie; H Whitrow
Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase.
Biochemical Society transactions 2003;31(Pt 6):1157-60.
2003: Angela Woods; Stephen R Johnstone; Kristina Dickerson; Fiona C Leiper; Lee G D Fryer; Dietbert Neumann; Uwe Schlattner; Theo Wallimann; Marian Carlson; David Carling
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
Current biology : CB 2003;13(22):2004-8.
2003: Angela Woods; Didier Vertommen; Dietbert Neumann; Roland Turk; Jayne Bayliss; Uwe Schlattner; Theo Wallimann; David Carling; Mark H Rider
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.
The Journal of biological chemistry 2003;278(31):28434-42.
2003: Seung-Pyo Hong; Fiona C Leiper; Angela Woods; David Carling; Marian Carlson
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8839-43.
2003: Mei Yu; Nigel K Stepto; Alexander V Chibalin; Lee G D Fryer; David Carling; Anna Krook; John A Hawley; Juleen R Zierath
Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise.
The Journal of physiology 2003;546(Pt 2):327-35.
2003: Benoit Viollet; Fabrizio Andreelli; Sebastian B Jørgensen; Christophe Perrin; Alain Geloen; Daisy Flamez; James Mu; Claudia Lenzner; Olivier Baud; Myriam Bennoun; Emmanuel Gomas; Gaël Nicolas; Jørgen F P Wojtaszewski; Axel Kahn; David Carling; Frans Schuit; Morris J Birnbaum; Erik A Richter; Rémy Burcelin; Sophie Vaulont
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.
The Journal of clinical investigation 2003;111(1):91-8.
2003: Reza Halse; Lee G D Fryer; James G McCormack; David Carling; Stephen J Yeaman
Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase.
Diabetes 2003;52(1):9-15.
2002: Tyrone Daniel; David Carling
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.
The Journal of biological chemistry 2002;277(52):51017-24.
2002: A P C Salgado; Dorit Schuller; Margarida Casal; Cecília Leão; Fiona C Leiper; David Carling; Luciano G Fietto; Maria José M Trópia; Ieso M Castro; Rogelio L Brandão
Relationship between protein kinase C and derepression of different enzymes.
FEBS letters 2002;532(3):324-32.
2002: Lee G D Fryer; Asha Parbu-Patel; David Carling
Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside.
FEBS letters 2002;531(2):189-92.
2002: Toshimasa Yamauchi; Junji Kamon; Yasuhiko Minokoshi; Yusuke Ito; Hironori Waki; Shoko Uchida; Shigeo Yamashita; Mitsuhiko Noda; Shunbun Kita; Keisuke Ueki; Kazuhiro Eto; Yasuo Akanuma; philippe froguel; Fabienne Foufelle; pascal ferre; David Carling; Satoshi Kimura; Ryozo Nagai; B B Kahn; Takashi Kadowaki
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Nature medicine 2002;8(11):1288-95.
2002: Brian R Barnes; Jeffrey W Ryder; Tatiana L Steiler; Lee G D Fryer; David Carling; Juleen R Zierath
Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction.
Diabetes 2002;51(9):2703-8.
2002: Tyrone Daniel; David Carling
Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits.
The Biochemical journal 2002;365(Pt 3):629-38.
2002: Lee G D Fryer; Asha Parbu-Patel; David Carling
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.
The Journal of biological chemistry 2002;277(28):25226-32.
2002: Kay Barnes; Jean C Ingram; Omar H Porras; Luis Felipe Barros; Emma R Hudson; Lee G D Fryer; Fabienne Foufelle; David Carling; D Grahame Hardie; Stephen A Baldwin
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK).
Journal of cell science 2002;115(Pt 11):2433-42.
2002: Rogelio L Brandão; L Etchebehere; C C Queiroz; Maria José M Trópia; J R Ernandes; T Gonçalves; M C Loureiro-Dias; Joris Winderickx; Johan M Thevelein; Fiona C Leiper; David Carling; Ieso M Castro
Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2.
FEMS yeast research 2002;2(2):93-102.
2002: Lee G D Fryer; Fabienne Foufelle; Kay Barnes; Stephen A Baldwin; Angela Woods; David Carling
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.
The Biochemical journal 2002;363(Pt 1):167-74.
2002: Yasuhiko Minokoshi; Young-Bum Kim; Odile D Peroni; Lee G D Fryer; Corinna Müller; David Carling; Barbara B Kahn
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
Nature 2002;415(6869):339-43.
2000: Lee G D Fryer; Eric Hajduch; F Rencurel; IP Salt; Harinder S Hundal; D Grahame Hardie; David Carling
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.
Diabetes 2000;49(12):1978-85.
2000: Anne-Sophie Marsin; Luc Bertrand; Mark H Rider; J Deprez; Christophe Beauloye; M F Vincent; G Van den Berghe; David Carling; Louis Hue
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia.
Current biology : CB 2000;10(20):1247-55.
2000: Angela Woods; D Azzout-Marniche; Marc Foretz; SC Stein; Patricia Lemarchand; Pascal Ferré; Fabienne Foufelle; David Carling
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase.
Molecular and cellular biology 2000;20(18):6704-11.
2000: PC Cheung; IP Salt; SP Davies; D Grahame Hardie; David Carling
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.
The Biochemical journal 2000;346 Pt 3():659-69.
2000: SC Stein; Angela Woods; N A Jones; M D Davison; David Carling
The regulation of AMP-activated protein kinase by phosphorylation.
The Biochemical journal 2000;345 Pt 3():437-43.
1999: Cristina Blázquez; A Woods; María L de Ceballos; David Carling; Manuel Guzmán
The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes.
Journal of neurochemistry 1999;73(4):1674-82.
1999: F C Smith; SP Davies; W A Wilson; David Carling; D Grahame Hardie
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1.
FEBS letters 1999;453(1-2):219-23.
1998: Guillermo Velasco; Teresa Gómez del Pulgar; David Carling; Manuel Guzmán
Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components.
FEBS letters 1998;439(3):317-20.
1998: Marc Foretz; David Carling; C Guichard; Pascal Ferré; Fabienne Foufelle
AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes.
The Journal of biological chemistry 1998;273(24):14767-71.
1998: C Thornton; M A Snowden; David Carling
Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.
The Journal of biological chemistry 1998;273(20):12443-50.
1998: Markella Ponticos; Qi-Long Lu; J E Morgan; D G Hardie; T A Partridge; David Carling
Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.
The EMBO journal 1998;17(6):1688-99.
1998: D G Hardie; David Carling; M Carlson
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
Annual review of biochemistry 1998;67():821-55.
1997: C Thornton; M A Snowden; David Carling
Identification of a novel AMPK beta subunit that is highly expressed in skeletal muscle.
Biochemical Society transactions 1997;25(4):S667.
1997: David Carling; Angela Woods; C Thornton; PC Cheung; F C Smith; Markella Ponticos; SC Stein
Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism.
Biochemical Society transactions 1997;25(4):1224-8.
1997: D Grahame Hardie; David Carling
The AMP-activated protein kinase--fuel gauge of the mammalian cell?
European journal of biochemistry / FEBS 1997;246(2):259-73.
1997: A B Sprenkle; SP Davies; David Carling; D Grahame Hardie; Thomas W Sturgill
Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.
FEBS letters 1997;403(3):254-8.
1996: A E Marley; J E Sullivan; David Carling; W M Abbott; G J Smith; I W Taylor; F Carey; R K Beri
Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha.
The Biochemical journal 1996;320 ( Pt 3)():801-6.
1996: A Woods; IP Salt; J Scott; D Grahame Hardie; David Carling
The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro.
FEBS letters 1996;397(2-3):347-51.
1996: Simon A Hawley; M Davison; A Woods; SP Davies; R K Beri; David Carling; D Grahame Hardie
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.
The Journal of biological chemistry 1996;271(44):27879-87.
1996: A Woods; P C Cheung; F C Smith; M D Davison; James Scott; R K Beri; David Carling
Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro.
The Journal of biological chemistry 1996;271(17):10282-90.
1995: Simon A Hawley; M A Selbert; E G Goldstein; Arthur M Edelman; David Carling; D Grahame Hardie
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms.
The Journal of biological chemistry 1995;270(45):27186-91.
1995: A J Verhoeven; A Woods; C H Brennan; Simon A Hawley; D Grahame Hardie; James Scott; R K Beri; David Carling
The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA.
European journal of biochemistry / FEBS 1995;228(2):236-43.
1994: R K Beri; A E Marley; Chee Gee See; W F Sopwith; K Aguan; David Carling; J Scott; F Carey
Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase.
FEBS letters 1994;356(1):117-21.
1994: D Grahame Hardie; David Carling; Nigel G Halford
Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress.
Seminars in cell biology 1994;5(6):409-16.
1994: J E Sullivan; K J Brocklehurst; A E Marley; F Carey; David Carling; R K Beri
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase.
FEBS letters 1994;353(1):33-6.
1994: A Woods; M R Munday; James Scott; X Yang; M Carlson; David Carling
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.
The Journal of biological chemistry 1994;269(30):19509-15.
1994: SP Davies; Simon A Hawley; A Woods; David Carling; T A Haystead; D Grahame Hardie
Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.
European journal of biochemistry / FEBS 1994;223(2):351-7.
1994: J E Sullivan; F Carey; David Carling; R K Beri
Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity.
Biochemical and biophysical research communications 1994;200(3):1551-6.
1994: David Carling; K Aguan; A Woods; A J Verhoeven; R K Beri; C H Brennan; C Sidebottom; M D Davison; James Scott
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism.
The Journal of biological chemistry 1994;269(15):11442-8.
1992: SP Davies; David Carling; M R Munday; D Grahame Hardie
Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets.
European journal of biochemistry / FEBS 1992;203(3):615-23.
1991: David Carling; Paul Clarke; D Grahame Hardie
Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.
Methods in enzymology 1991;200():362-71.
1989: David Carling; Paul Clarke; V A Zammit; D Grahame Hardie
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.
European journal of biochemistry / FEBS 1989;186(1-2):129-36.
1989: SP Davies; David Carling; D Grahame Hardie
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay.
European journal of biochemistry / FEBS 1989;186(1-2):123-8.
1989: David Carling; D Grahame Hardie
The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase.
Biochimica et biophysica acta 1989;1012(1):81-6.
1989: T A Haystead; A T Sim; David Carling; R C Honnor; Y Tsukitani; Philip Cohen; D Grahame Hardie
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.
Nature 1989;337(6202):78-81.
1988: M R Munday; David Carling; D Grahame Hardie
Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases.
FEBS letters 1988;235(1-2):144-8.
1988: M R Munday; D G Campbell; David Carling; D Grahame Hardie
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.
European journal of biochemistry / FEBS 1988;175(2):331-8.
1987: David Carling; V A Zammit; D Grahame Hardie
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.
FEBS letters 1987;223(2):217-22.
1986: M R Munday; T A Haystead; R Holland; David Carling; D G Hardie
The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis.
Biochemical Society transactions 1986;14(3):559-62.