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Laith Al-Mawsawi

Research Profile

Chemicals & Drugs

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HIV Infections

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Nicholas C Wu; Ting-Ting Wu; Arthur P Young; Laith Q Al-Mawsawi; Sugandha Dandekar; Hemani Wijersuriya; Ren Sun
Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening.
C Anders Olson; Richard W Roberts; H Tom Soh; Ron Stewart; Laith Q Al-Mawsawi; Ibrahim Al-Shyoukh; Jennifer M Bolin; Jonathan Diep; Angela L Elwell; Jeff Nie; Scott Swanson; Terry T Takahashi; James A Thomson; Ren Sun
Single-round, multiplexed antibody mimetic design through mRNA display.
Erik Serrao; Wannes Thys; Laith Q Al-Mawsawi; Frauke Christ; zeger debyser; Jonas Demeulemeester; Nouri Neamati
A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication.

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All Publications

2013: Nicholas C Wu; Ting-Ting Wu; Arthur P Young; Laith Q Al-Mawsawi; Sugandha Dandekar; Hemani Wijersuriya; Ren Sun
Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening.
Journal of virology 2013;87(2):1193-9.
2012: C Anders Olson; Richard W Roberts; H Tom Soh; Ron Stewart; Laith Q Al-Mawsawi; Ibrahim Al-Shyoukh; Jennifer M Bolin; Jonathan Diep; Angela L Elwell; Jeff Nie; Scott Swanson; Terry T Takahashi; James A Thomson; Ren Sun
Single-round, multiplexed antibody mimetic design through mRNA display.
Angewandte Chemie (International ed. in English) 2012;51(50):12449-53.
2012: Erik Serrao; Wannes Thys; Laith Q Al-Mawsawi; Frauke Christ; zeger debyser; Jonas Demeulemeester; Nouri Neamati
A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication.
PloS one 2012;7(9):e45177.
2011: Laith Q Al-Mawsawi; Nouri Neamati
Allosteric inhibitor development targeting HIV-1 integrase.
ChemMedChem 2011;6(2):228-41.
2010: Bikash Debnath; Laith Q Al-Mawsawi; Nouri Neamati
Are we living in the end of the blockbuster drug era?
Drug news & perspectives 2010;23(10):670-84.
2008: Laith Q Al-Mawsawi; Anneleen Hombrouck; Raveendra Dayam; zeger debyser; Nouri Neamati
Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity.
Virology 2008;377(2):355-63.
2008: Laith Q Al-Mawsawi; Rasha I Al-Safi; Nouri Neamati
Anti-infectives: clinical progress of HIV-1 integrase inhibitors.
Expert opinion on emerging drugs 2008;13(2):213-25.
2008: Laith Q Al-Mawsawi; Frauke Christ; Raveendra Dayam; zeger debyser; Nouri Neamati
Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.
FEBS letters 2008;582(10):1425-30.
2008: Raveendra Dayam; Laith Q Al-Mawsawi; Zahrah Zawahir; Myriam Witvrouw; zeger debyser; Nouri Neamati
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.
Journal of medicinal chemistry 2008;51(5):1136-44.
2008: Raveendra Dayam; Rambabu Gundla; Laith Q Al-Mawsawi; Nouri Neamati
HIV-1 integrase inhibitors: 2005-2006 update.
Medicinal research reviews 2008;28(1):118-54.
2007: Laith Q Al-Mawsawi; Raveendra Dayam; Laleh Taheri; Myriam Witvrouw; zeger debyser; Nouri Neamati
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(23):6472-5.
2007: Raveendra Dayam; Laith Q Al-Mawsawi; Nouri Neamati
Substituted 2-pyrrolinone inhibitors of HIV-1 integrase.
Bioorganic & medicinal chemistry letters 2007;17(22):6155-9.
2007: Laith Q Al-Mawsawi; Nouri Neamati
Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy.
Trends in pharmacological sciences 2007;28(10):526-35.
2007: Jinxia Deng; Tino Sanchez; Laith Q Al-Mawsawi; Raveendra Dayam; Rosendo A Yunes; Antonio Garofalo; Michael B Bolger; Nouri Neamati
Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.
Bioorganic & medicinal chemistry 2007;15(14):4985-5002.
2007: Laith Q Al-Mawsawi; Mario Sechi; Nouri Neamati
Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity.
FEBS letters 2007;581(6):1151-6.
2007: Raveendra Dayam; Laith Q Al-Mawsawi; Nouri Neamati
HIV-1 integrase inhibitors: an emerging clinical reality.
Drugs in R&D 2007;8(3):155-68.
2007: Jinxia Deng; Raveendra Dayam; Laith Q Al-Mawsawi; Nouri Neamati
Design of second generation HIV-1 integrase inhibitors.
Current pharmaceutical design 2007;13(2):129-41.
2006: Mario Sechi; Alessia Bacchi; Mauro Carcelli; Carlotta Compari; Elenia Duce; Emilia Fisicaro; Dominga Rogolino; Paul Gates; Massimiliano Derudas; Laith Q Al-Mawsawi; Nouri Neamati
From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.
Journal of medicinal chemistry 2006;49(14):4248-60.
2006: Laith Q Al-Mawsawi; Valery Fikkert; Raveendra Dayam; Myriam Witvrouw; Terrence R Burke; Christoph H Borchers; Nouri Neamati
Discovery of a small-molecule HIV-1 integrase inhibitor-binding site.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):10080-5.
2004: Timothy F Braun; Laith Q Al-Mawsawi; Seiji Kojima; David F Blair
Arrangement of core membrane segments in the MotA/MotB proton-channel complex of Escherichia coli.
Biochemistry 2004;43(1):35-45.