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Darrell R. Abernethy

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Jane P F Bai; Darrell R. Abernethy
Systems pharmacology to predict drug toxicity: integration across levels of biological organization.
P E Zhichkin; B D Athey; Mark I Avigan; Darrell R. Abernethy
Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms.
D Gnjidic; D J Handelsman; Sarah N Hilmer; Darrell R. Abernethy; E Banks; F M Blyth; R G Cumming; A J McLachlan; Vasi Naganathan; D G Le Couteur
High-risk prescribing and incidence of frailty among older community-dwelling men.

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2013: Jane P F Bai; Darrell R. Abernethy
Systems pharmacology to predict drug toxicity: integration across levels of biological organization.
Annual review of pharmacology and toxicology 2013;53():451-73.
2012: P E Zhichkin; B D Athey; Mark I Avigan; Darrell R. Abernethy
Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms.
Clinical pharmacology and therapeutics 2012;91(6):963-5.
2012: D Gnjidic; D J Handelsman; Sarah N Hilmer; Darrell R. Abernethy; E Banks; F M Blyth; R G Cumming; A J McLachlan; Vasi Naganathan; D G Le Couteur
High-risk prescribing and incidence of frailty among older community-dwelling men.
Clinical pharmacology and therapeutics 2012;91(3):521-8.
2012: Sarah N Hilmer; Danijela Gnjidic; Darrell R. Abernethy
Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(2):181-8.
2012: Yongqun He; Cui Tao; Luca Toldo; Gully Burns; Darrell R. Abernethy
A 2012 Workshop: Vaccine and Drug Ontology in the Study of Mechanism and Effect (VDOSME 2012).
Journal of biomedical semantics 2012;3(1):12.
2012: Ping Zhao; Jenny H Zheng; Eva Gil Berglund; Darrell R. Abernethy; Vikram Arya; Arthur J Atkinson; Joseph A Grillo; Lawrence J Lesko; K Sandy Pang; Kellie S Reynolds; Pengfei Song; Yuichi Sugiyama; Manuela de L T Vieira; Ta-Chen Wu; Lei Zhang; Shiew-Mei Huang
Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.
Journal of clinical pharmacology 2012;52(1 Suppl):91S-108S.
2011: Darrell R. Abernethy; J P F Bai; K Burkhart; H-G Xie; P Zhichkin
Integration of diverse data sources for prediction of adverse drug events.
Clinical pharmacology and therapeutics 2011;90(5):645-6.
2011: Darrell R. Abernethy; J Woodcock; Lawrence J Lesko
Pharmacological mechanism-based drug safety assessment and prediction.
Clinical pharmacology and therapeutics 2011;89(6):793-7.
2011: Seongeun Cho; S W Johnny Lau; Veneeta Tandon; Kofi Kumi; Elimika Pfuma; Darrell R. Abernethy
Geriatric drug evaluation: where are we now and where should we be in the future?
Archives of internal medicine 2011;171(10):937-40.
2011: Danijela Gnjidic; DAVID LE COUTEUR; Darrell R. Abernethy; Sarah N Hilmer
Reducing drugs in older adults is more.
Archives of internal medicine 2011;171(9):868-9.
2010: Danijela Gnjidic; DAVID LE COUTEUR; Darrell R. Abernethy; Sarah N Hilmer
A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people.
The Annals of pharmacotherapy 2010;44(11):1725-32.
2010: Julian F Thayer; Bart Verkuil; Jos F Brosschot; Kevin Kampschroer; Anthony West; Carolyn Sterling; Israel C Christie; Darrell R. Abernethy; John J Sollers; Giovanni Cizza; Andrea H Marques; Esther M Sternberg
Effects of the physical work environment on physiological measures of stress.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2010;17(4):431-9.
2010: Darrell R. Abernethy; Anthony J Destefano; Todd L Cecil; Kahkashan Zaidi; Roger L Williams
Metal impurities in food and drugs.
Pharmaceutical research 2010;27(5):750-5.
2010: Darrell R. Abernethy; G J Burckart
Pediatric dose selection.
Clinical pharmacology and therapeutics 2010;87(3):270-1.
2010: Michael J Hanley; Darrell R. Abernethy; David J Greenblatt
Effect of obesity on the pharmacokinetics of drugs in humans.
Clinical pharmacokinetics 2010;49(2):71-87.
2009: Sarah N Hilmer; Donald E Mager; Eleanor M Simonsick; Shari Miura Ling; B Gwen Windham; Tamara B Harris; Ronald I Shorr; Douglas Charles Bauer; Darrell R. Abernethy
Drug burden index score and functional decline in older people.
The American journal of medicine 2009;122(12):1142-1149.e1-2.
2009: Danijela Gnjidic; Robert G Cumming; DAVID LE COUTEUR; David J Handelsman; Vasi Naganathan; Darrell R. Abernethy; Sarah N Hilmer
Drug Burden Index and physical function in older Australian men.
British journal of clinical pharmacology 2009;68(1):97-105.
2009: Darrell R. Abernethy; C Sheehan; J C Griffiths; Roger L Williams
Adulteration of drugs and foods: compendial approaches to lowering risk.
Clinical pharmacology and therapeutics 2009;85(4):444-7.
2009: Walter W Hauck; Anthony J DeStefano; William E Brown; Erika S Stippler; Darrell R. Abernethy; William F Koch; Roger L Williams
Change in criteria for USP dissolution performance verification tests.
AAPS PharmSciTech 2009;10(1):21-6.
2009: Anthony Woo; Tian-Bing Wang; Xiaokun Zeng; Weizhong Zhu; Darrell R. Abernethy; irving william wainer; Rui-Ping Xiao
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes.
Molecular pharmacology 2009;75(1):158-65.
2009: Shari Miura Ling; Dhavalkumar D Patel; P Garnero; Min Zhan; M Vaduganathan; D Muller; D Taub; Joan M Bathon; Marc C Hochberg; Darrell R. Abernethy; E J Metter; Luigi Ferrucci
Serum protein signatures detect early radiographic osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(1):43-8.
2008: Walter W Hauck; Darrell R. Abernethy; Roger L Williams
Metrologic approaches to setting acceptance criteria: unacceptable and unusual characteristics.
Journal of pharmaceutical and biomedical analysis 2008;48(3):1042-5.
2008: Sarah N Hilmer; Darrell R. Abernethy
Measures of drug toxicity in older adults.
Archives of internal medicine 2008;168(17):1930-1; author reply 1931-2.
2008: David A Flockhart; Darrell R. Abernethy
Finding the right research question: quality science depends on quality careers.
Clinical pharmacology and therapeutics 2008;84(3):427-9.
2008: YING-JUN CAO; Donald E Mager; Eleanor M Simonsick; Sarah N Hilmer; Shari Miura Ling; B Gwen Windham; VICTOR CRENTSIL; Sevil Yasar; Linda P Fried; Darrell R. Abernethy
Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women.
Clinical pharmacology and therapeutics 2008;83(3):422-9.
2008: Lisa D DiMartino; Lesley H Curtis; Roger L Williams; Darrell R. Abernethy; Kevin Schulman
Using Medicare administrative data to conduct postmarketing surveillance of follow-on biologics: issues and opportunities.
Food and drug law journal 2008;63(4):891-900.
2007: Danuta Siluk; Donald E Mager; Naomi Gronich; Darrell R. Abernethy; irving william wainer
HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;859(2):213-21.
2007: Donald E Mager; Evgeny Kobrinsky; Amirali Masoudieh; Anna Maltsev; Darrell R. Abernethy; Nikolai M Soldatov
Analysis of functional signaling domains from fluorescence imaging and the two-dimensional continuous wavelet transform.
Biophysical journal 2007;93(8):2900-10.
2007: Shari Miura Ling; Robin A Conwit; Laura A Talbot; M Shermack; J E Wood; E M Dredge; M J Weeks; Darrell R. Abernethy; E Jeffrey Metter
Electromyographic patterns suggest changes in motor unit physiology associated with early osteoarthritis of the knee.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(10):1134-40.
2007: Krzysztof Jozwiak; Chakir Khalid; Mary J Tanga; Ilona Berzetei-Gurske; Lucita Jimenez; Joseph A Kozocas; Anthony Woo; Weizhong Zhu; Rui-Ping Xiao; Darrell R. Abernethy; irving william wainer
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.
Journal of medicinal chemistry 2007;50(12):2903-15.
2007: Mary Ann Mascelli; Honghui Zhou; Raymond Sweet; Jay Getsy; Hugh M Davis; Martin Graham; Darrell R. Abernethy
Molecular, biologic, and pharmacokinetic properties of monoclonal antibodies: impact of these parameters on early clinical development.
Journal of clinical pharmacology 2007;47(5):553-65.
2007: Donald E Mager; Darrell R. Abernethy
Use of wavelet and fast Fourier transforms in pharmacodynamics.
The Journal of pharmacology and experimental therapeutics 2007;321(2):423-30.
2007: Sarah N Hilmer; Donald E Mager; Eleanor M Simonsick; YING-JUN CAO; Shari Miura Ling; B Gwen Windham; Tamara B Harris; Joseph T Hanlon; Susan M Rubin; Ronald I Shorr; Douglas Charles Bauer; Darrell R. Abernethy
A drug burden index to define the functional burden of medications in older people.
Archives of internal medicine 2007;167(8):781-7.
2007: Hamish A Jamieson; Sarah N Hilmer; Victoria C Cogger; Alessandra Warren; Rajkumar Cheluvappa; Darrell R. Abernethy; Arthur V Everitt; Robin Fraser; Rafael de Cabo; DAVID LE COUTEUR
Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid.
Experimental gerontology 2007;42(4):374-8.
2006: Swasti Tiwari; Yuwei Zhang; Jennifer Heller; Darrell R. Abernethy; Nikolai M Soldatov
Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):17024-9.
2006: Farideh Beigi; Carlo Bertucci; Weizhong Zhu; Khalid Chakir; irving william wainer; Rui-Ping Xiao; Darrell R. Abernethy
Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol.
Chirality 2006;18(10):822-7.
2006: Donald E Mager; Ruiqian Wan; Martin Brown; Aiwu Cheng; Przemyslaw Wareski; Darrell R. Abernethy; Mark P Mattson
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(6):631-7.
2005: Donald E Mager; Jason D Shirey; Dermot Cox; Desmond J Fitzgerald; Darrell R. Abernethy
Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network.
Journal of pharmaceutical sciences 2005;94(11):2475-86.
2005: Evgeny Kobrinsky; Donald E Mager; Sarah A Bentil; Shin-Ichi Murata; Darrell R. Abernethy; Nikolai M Soldatov
Identification of plasma membrane macro- and microdomains from wavelet analysis of FRET microscopy.
Biophysical journal 2005;88(5):3625-34.
2005: Evgeny Kobrinsky; Swasti Tiwari; Victor A Maltsev; Jo Beth Harry; Edward G Lakatta; Darrell R. Abernethy; Nikolai M Soldatov
Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions.
The Journal of biological chemistry 2005;280(13):12474-85.
2004: Jo Beth Harry; Evgeny Kobrinsky; Darrell R. Abernethy; Nikolai M Soldatov
New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel.
The Journal of biological chemistry 2004;279(45):46367-72.
2004: Donald E Mager; Darrell R. Abernethy; Josephine M Egan; Dariush Elahi
Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique.
The Journal of pharmacology and experimental therapeutics 2004;311(2):830-5.
2004: Evgeny Kobrinsky; Klaus J F Kepplinger; Alexander Yu; Jo Beth Harry; Heike Kahr; Christoph Romanin; Darrell R. Abernethy; Nikolai M Soldatov
Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation.
Biophysical journal 2004;87(2):844-57.
2004: Donald E Mager; Marcellus M Merritt; Jyotsna Kasturi; Lisa R Witkin; Mirna Urdiqui-Macdonald; John J Sollers; Michele K Evans; Alan B Zonderman; Darrell R. Abernethy; Julian Thayer
Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability.
Biomedical sciences instrumentation 2004;40():337-42.
2004: Mirna Urquidi-Macdonald; Donald E Mager; Mary Ann Mascelli; Bart Frederick; Jane Freedman; Desmond J Fitzgerald; Neal S Kleiman; Darrell R. Abernethy
Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability.
Clinical pharmacology and therapeutics 2004;75(1):60-9.
2003: Julian Thayer; Marcellus M Merritt; John J Sollers; Alan B Zonderman; Michele K Evans; Sue Yie; Darrell R. Abernethy
Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans.
The American journal of cardiology 2003;92(12):1487-90.
2003: Donald E Mager; Mary Ann Mascelli; Neal S Kleiman; Desmond J Fitzgerald; Darrell R. Abernethy
Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty.
The Journal of pharmacology and experimental therapeutics 2003;307(3):969-76.
2003: Enika Nagababu; Somasundaram Ramasamy; Darrell R. Abernethy; Joseph M Rifkind
Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction.
The Journal of biological chemistry 2003;278(47):46349-56.
2003: Evgeny Kobrinsky; Elena Schwartz; Darrell R. Abernethy; Nikolai M Soldatov
Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role.
The Journal of biological chemistry 2003;278(7):5021-8.
2002: Jose E Tanus-Santos; Mehul Desai; Leslie R Deak; John C Pezzullo; Darrell R. Abernethy; David A Flockhart; Jane E Freedman
Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol.
Pharmacogenetics 2002;12(5):407-13.
2002: Darrell R. Abernethy; John Pezzullo; Mary Ann Mascelli; Bart Frederick; Neal S Kleiman; Jane Freedman
Pharmacodynamics of abciximab during angioplasty: comparison to healthy subjects.
Clinical pharmacology and therapeutics 2002;71(3):186-95.
2002: Darrell R. Abernethy; Nikolai M Soldatov
Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets.
The Journal of pharmacology and experimental therapeutics 2002;300(3):724-8.
2002: Jane Freedman; Mary Ann Mascelli; John C Pezzullo; Elliot S Barnathan; Bart Frederick; Robert E Jordan; Darrell R. Abernethy
Pharmacodynamic profile of short-term readministration of abciximab in healthy subjects.
American heart journal 2002;143(1):87-94.
2001: Darrell R. Abernethy; DL Wesche; Jean T Barbey; C Ohrt; S Mohanty; John C Pezzullo; BG Schuster
Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation.
British journal of clinical pharmacology 2001;51(3):231-7.
2001: Darrell R. Abernethy; Jean T Barbey; J Franc; K S Brown; I Feirrera; N Ford; Daniel Salazar
Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation.
Clinical pharmacology and therapeutics 2001;69(3):96-103.
2000: Christoph Romanin; Roland Gamsjaeger; Heike Kahr; D Schaufler; O Carlson; Darrell R. Abernethy; Nikolai M Soldatov
Ca(2+) sensors of L-type Ca(2+) channel.
FEBS letters 2000;487(2):301-6.
2000: Nikolai M Soldatov; S Zhenochin; B AlBanna; Darrell R. Abernethy; Martin Morad
New molecular determinant for inactivation of the human L-type alpha1C Ca2+ channel.
The Journal of membrane biology 2000;177(2):129-35.
2000: Darrell R. Abernethy; irving william wainer; A I Anacleto
Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(7):760-5.
2000: Darrell R. Abernethy; D A Flockhart
Molecular basis of cardiovascular drug metabolism: implications for predicting clinically important drug interactions.
Circulation 2000;101(14):1749-53.
2000: Daniel A Spyker; E D Harvey; B E Harvey; A M Harvey; Barry H Rumack; C C Peck; A J Atkinson; Raymond L Woosley; Darrell R. Abernethy; Louis R Cantilena
Assessment and reporting of clinical pharmacology information in drug labeling.
Clinical pharmacology and therapeutics 2000;67(3):196-200.
2000: NS Andrawis; M M Battle; K J Klamerus; P H Burghart; L Neefe; I Weinryb; P Mayer; Darrell R. Abernethy
A pharmacokinetic and pharmacodynamic study of the potential drug interaction between tasosartan and atenolol in patients with stage 1 and 2 essential hypertension.
Journal of clinical pharmacology 2000;40(3):231-41.
2000: NS Andrawis; D S Jones; Darrell R. Abernethy
Aging is associated with endothelial dysfunction in the human forearm vasculature.
Journal of the American Geriatrics Society 2000;48(2):193-8.
1999: Hui C Kimko; J T Cross; Darrell R. Abernethy
Pharmacokinetics and clinical effectiveness of methylphenidate.
Clinical pharmacokinetics 1999;37(6):457-70.
1999: S Donahue; David A Flockhart; Darrell R. Abernethy
Ticlopidine inhibits phenytoin clearance.
Clinical pharmacology and therapeutics 1999;66(6):563-8.
1999: Darrell R. Abernethy; J B Schwartz
Calcium-antagonist drugs.
The New England journal of medicine 1999;341(19):1447-57.
1999: Kevin Schulman; Darrell R. Abernethy; S S Rathore; Raymond L Woosley
Regulating manufacturer-affiliated communication in the information age.
Clinical pharmacology and therapeutics 1999;65(6):593-7.
1999: D S Jones; NS Andrawis; Darrell R. Abernethy
Impaired endothelial-dependent forearm vascular relaxation in black Americans.
Clinical pharmacology and therapeutics 1999;65(4):408-12.
1999: I Rodriguez; Darrell R. Abernethy; Raymond L Woosley
P-Glycoprotein in clinical cardiology.
Circulation 1999;99(4):472-4.
1999: Darrell R. Abernethy
Aging effects on drug disposition and effect.
Geriatric nephrology and urology 1999;9(1):15-9.
1998: CB Trapnell; S R Donahue; Jerry M Collins; David A Flockhart; DL Thacker; Darrell R. Abernethy
Thalidomide does not alter the pharmacokinetics of ethinyl estradiol and norethindrone.
Clinical pharmacology and therapeutics 1998;64(6):597-602.
1998: M Oz; Michael THOMAS Melia; Nikolai M Soldatov; Darrell R. Abernethy; Martin Morad
Functional coupling of human L-type Ca2+ channels and angiotensin AT1A receptors coexpressed in xenopus laevis oocytes: involvement of the carboxyl-terminal Ca2+ sensors.
Molecular pharmacology 1998;54(6):1106-12.
1998: DL Thacker; Darrell R. Abernethy; A Raines; David A Flockhart
Method for the determination of 5,5-diphenylbarbituric acid and its separation from 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid in plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1998;710(1-2):149-55.
1998: Yuichiro J Suzuki; Lars Cleemann; Darrell R. Abernethy; Martin Morad
Glutathione is a cofactor for H2O2-mediated stimulation of Ca2+-induced Ca2+ release in cardiac myocytes.
Free radical biology & medicine 1998;24(2):318-25.
1998: Nikolai M Soldatov; M Oz; K A O'Brien; Darrell R. Abernethy; Martin Morad
Molecular determinants of L-type Ca2+ channel inactivation. Segment exchange analysis of the carboxyl-terminal cytoplasmic motif encoded by exons 40-42 of the human alpha1C subunit gene.
The Journal of biological chemistry 1998;273(2):957-63.
1998: X K Liu; Darrell R. Abernethy; NS Andrawis
Nitric oxide inhibits Oct-1 DNA binding activity in cultured vascular smooth muscle cells.
Life sciences 1998;62(8):739-49.
1997: S R Donahue; David A Flockhart; Darrell R. Abernethy; JW Ko
Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19.
Clinical pharmacology and therapeutics 1997;62(5):572-7.
1997: Darrell R. Abernethy
Pharmacologic and pharmacokinetic profile of mibefradil, a T- and L-type calcium channel antagonist.
The American journal of cardiology 1997;80(4B):4C-11C.
1997: S J Shi; Harry G Preuss; Darrell R. Abernethy; X Li; ST Jarrell; NS Andrawis
Elevated blood pressure in spontaneously hypertensive rats consuming a high sucrose diet is associated with elevated angiotensin II and is reversed by vanadium.
Journal of hypertension 1997;15(8):857-62.
1997: Suzanne Oparil; Isaac Kobrin; Darrell R. Abernethy; B S Levine; M C Reif; Alexander Shepherd
Dose-response characteristics of mibefradil, a novel calcium antagonist, in the treatment of essential hypertension.
American journal of hypertension 1997;10(7 Pt 1):735-42.
1997: Darrell R. Abernethy
Grapefruits and drugs: when is statistically significant clinically significant?
The Journal of clinical investigation 1997;99(10):2297-8.
1997: Joseph M Scavone; David J Greenblatt; Darrell R. Abernethy; B G Luna; Jerold S Harmatz; Richard I Shader
Influence of oral contraceptive use and cigarette smoking, alone and together, on antipyrine pharmacokinetics.
Journal of clinical pharmacology 1997;37(5):437-41.
1997: Joel M Neutel; Darrell R. Abernethy; M Moser; R W Gifford; W H Frishman
Discussion: recent data on the safety and efficacy of newer therapies in the management of hypertension.
American journal of hypertension 1997;10(3):24S-26S.
1997: Darrell R. Abernethy
Pharmacological properties of combination therapies for hypertension.
American journal of hypertension 1997;10(3):13S-16S.
1996: Prafulla C Gokhale; B Radhakrishnan; S R Husain; Darrell R. Abernethy; R Sacher; Anatoly Dritschilo; Aquilur Rahman
An improved method of encapsulation of doxorubicin in liposomes: pharmacological, toxicological and therapeutic evaluation.
British journal of cancer 1996;74(1):43-8.
1996: Kevin Schulman; L E Rubenstein; Darrell R. Abernethy; D M Seils; Daniel P Sulmasy
The effect of pharmaceutical benefits managers: is it being evaluated?
Annals of internal medicine 1996;124(10):906-13.
1996: NS Andrawis; E Wang; Darrell R. Abernethy
Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells.
Life sciences 1996;59(7):523-8.
1995: Darrell R. Abernethy; N Laurie; N S Andrawis
Local angiotensin-converting enzyme inhibition blunts endothelin-1-induced increase in forearm vascular resistance.
Clinical pharmacology and therapeutics 1995;58(3):328-34.
1995: Darrell R. Abernethy; A A Fox; M Stimpel
Moexipril in the treatment of mild to moderate essential hypertension: comparison with sustained-release verapamil.
Journal of clinical pharmacology 1995;35(8):794-9.
1995: J G Niedzwicki; C Liou; Darrell R. Abernethy; J E Lima; A Hoyt; M Lieberman; N C Bethlenfalvay
Adenosine deaminase isoenzymes of the opossum Didelphis virginiana: initial chromatographic and kinetic studies.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1995;111(2):291-8.
1994: Darrell R. Abernethy
An overview of the pharmacokinetics and pharmacodynamics of amlodipine in elderly persons with systemic hypertension.
The American journal of cardiology 1994;73(3):10A-17A.
1994: P B DePetrillo; Darrell R. Abernethy; irving william wainer; N S Andrawis
Verapamil decreases lymphocyte protein kinase C activity in humans.
Clinical pharmacology and therapeutics 1994;55(1):44-9.
1993: N S Andrawis; E H Ruley; Darrell R. Abernethy
Angiotensin II regulates human vascular smooth muscle alpha-actin gene expression.
Biochemical and biophysical research communications 1993;196(2):962-8.
1993: N S Andrawis; Darrell R. Abernethy
Effect of calcium antagonists on RNA synthesis of NIH 3T3 cells.
The American journal of the medical sciences 1993;306(3):137-40.
1993: Darrell R. Abernethy; irving william wainer; J A Longstreth; N S Andrawis
Stereoselective verapamil disposition and dynamics in aging during racemic verapamil administration.
The Journal of pharmacology and experimental therapeutics 1993;266(2):904-11.
1993: Darrell R. Abernethy; Alexander Shepherd; D W Nierenberg
Clinical pharmacologists and health care reform: contributing to the debate.
Clinical pharmacology and therapeutics 1993;54(2):123-5.
1993: Darrell R. Abernethy
Antihypertensive therapy: a look ahead.
Rhode Island medicine 1993;76(5):255-7.
1993: L L von Moltke; Darrell R. Abernethy; M M Kaplan; D J Greenblatt
Antipyrine kinetics in patients with primary biliary cirrhosis.
Journal of clinical pharmacology 1993;33(1):75-7.
1992: N S Andrawis; J Gilligan; Darrell R. Abernethy
Endothelin-I-mediated vasoconstriction: specific blockade by verapamil.
Clinical pharmacology and therapeutics 1992;52(6):583-9.
1992: N S Andrawis; N Craft; Darrell R. Abernethy
Calcium antagonists block angiotensin II-mediated vasoconstriction in humans: comparison with their effect on phenylephrine-induced vasoconstriction.
The Journal of pharmacology and experimental therapeutics 1992;261(3):879-84.
1992: N S Andrawis; Darrell R. Abernethy
Verapamil blocks basal and angiotensin II-induced RNA synthesis of rat aortic vascular smooth muscle cells.
Biochemical and biophysical research communications 1992;183(2):767-73.
1992: Darrell R. Abernethy
Pharmacokinetics and pharmacodynamics of amlodipine.
Cardiology 1992;80 Suppl 1():31-6.
1991: Darrell R. Abernethy
Workshop on drug utilization review. A practitioner's point of view.
Clinical pharmacology and therapeutics 1991;50(5 Pt 2):612-3.
1991: J G Niedzwicki; K H Mayer; E Abushanab; Darrell R. Abernethy
Plasma adenosine deaminase2 is a marker for human immunodeficiency virus-1 seroconversion.
American journal of hematology 1991;37(3):152-5.
1991: J G Niedzwicki; Darrell R. Abernethy
Structure-activity relationship of ligands of human plasma adenosine deaminase2.
Biochemical pharmacology 1991;41(11):1615-24.
1991: Darrell R. Abernethy; L S Kaminsky; T H Dickinson
Selective inhibition of warfarin metabolism by diltiazem in humans.
The Journal of pharmacology and experimental therapeutics 1991;257(1):411-5.
1991: Darrell R. Abernethy
Amlodipine: pharmacokinetic profile of a low-clearance calcium antagonist.
Journal of cardiovascular pharmacology 1991;17 Suppl 1():S4-7.
1991: J G Niedzwicki; N M Kouttab; K H Mayer; C C Carpenter; R E Parks; E Abushanab; Darrell R. Abernethy
Plasma adenosine deaminase2: a marker for human immunodeficiency virus infection.
Journal of acquired immune deficiency syndromes 1991;4(2):178-82.
1990: Darrell R. Abernethy; D L Azarnoff
Pharmacokinetic investigations in elderly patients. Clinical and ethical considerations.
Clinical pharmacokinetics 1990;19(2):89-93.
1990: Darrell R. Abernethy; J Gutkowska; Lisa Winterbottom
Effects of amlodipine, a long-acting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition.
Clinical pharmacology and therapeutics 1990;48(1):76-86.
1990: Darrell R. Abernethy; Lisa Winterbottom
Forearm vascular alpha 1-adrenergic blockade by verapamil.
Clinical pharmacology and therapeutics 1990;47(6):755-9.
1990: P B DePetrillo; Robert Swift; C Ambroise; Darrell R. Abernethy
High-performance liquid chromatographic determination of 3',5'-cyclic adenosine monophosphate in human platelets.
Journal of chromatography 1990;527(2):421-7.
1990: Darrell R. Abernethy
Altered pharmacodynamics of cardiovascular drugs and their relation to altered pharmacokinetics in elderly patients.
Clinics in geriatric medicine 1990;6(2):285-92.
1990: S C Tsao; T H Dickinson; Darrell R. Abernethy
Metabolite inhibition of parent drug biotransformation. Studies of diltiazem.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(2):180-2.
1990: Darrell R. Abernethy
Research challenges, new drug development, preclinical and clinical trials in the ageing population.
Drug safety : an international journal of medical toxicology and drug experience 1990;5 Suppl 1():71-4.
1989: Darrell R. Abernethy
The pharmacokinetic profile of amlodipine.
American heart journal 1989;118(5 Pt 2):1100-3.
1989: D C Hill; Patrick Wouters; J E Chelly; M F Doursout; Darrell R. Abernethy; Craig J Hartley; R G Merin
Cardiovascular effects of and interaction between calcium blocking drugs and anesthetics in chronically instrumented dogs: VII. Verapamil and thiopental.
Anesthesiology 1989;71(4):586-90.
1989: Darrell R. Abernethy
Clinical judgment in geriatric hypertension.
Hospital practice (Office ed.) 1989;24(9A):7-11.
1989: S C Montamat; Darrell R. Abernethy
Calcium antagonists in geriatric patients: diltiazem in elderly persons with hypertension.
Clinical pharmacology and therapeutics 1989;45(6):682-91.
1989: Darrell R. Abernethy; J C Alper; M C Wiemann; C J McDonald; P Calabresi
Oral 5-fluorouracil in psoriasis: pharmacokinetic-pharmacodynamic relationships.
Pharmacology 1989;39(2):78-88.
1989: David J Greenblatt; M K Divoll; Darrell R. Abernethy; H R Ochs; Jerold S Harmatz; Richard I Shader
Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition.
Pharmacology 1989;38(5):327-34.
1988: P Wolfson; Darrell R. Abernethy; D J DiPette; R Zusman
Diltiazem and captopril alone or in combination for treatment of mild to moderate systemic hypertension.
The American journal of cardiology 1988;62(11):103G-108G.
1988: Jean-Marc Burgunder; Darrell R. Abernethy; Bernhard H Lauterburg
Liver injury due to verapamil.
Hepato-gastroenterology 1988;35(4):169-70.
1988: Darrell R. Abernethy; J B Schwartz
Pharmacokinetics of calcium antagonists under development.
Clinical pharmacokinetics 1988;15(1):1-14.
1988: D C Hill; J E Chelly; A Dlewati; Darrell R. Abernethy; M F Doursout; R G Merin
Cardiovascular effects of and interaction between calcium blocking drugs and anesthetics in chronically instrumented dogs. VI. Verapamil and fentanyl-pancuronium.
Anesthesiology 1988;68(6):874-9.
1988: Darrell R. Abernethy; J M Egan; T H Dickinson; G Carrum
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans.
The Journal of pharmacology and experimental therapeutics 1988;244(3):994-9.
1988: Darrell R. Abernethy; J B Schwartz
Verapamil pharmacodynamics and disposition in obese hypertensive patients.
Journal of cardiovascular pharmacology 1988;11(2):209-15.
1988: T H Dickinson; J M Egan; Darrell R. Abernethy
Effects of nifedipine on hepatic drug oxidation.
Pharmacology 1988;36(6):405-10.
1988: L G Miller; David J Greenblatt; Darrell R. Abernethy; H Friedman; M D Luu; S M Paul; R I Shader
Kinetics, brain uptake, and receptor binding characteristics of flurazepam and its metabolites.
Psychopharmacology 1988;94(3):386-91.
1988: Darrell R. Abernethy; J Gutkowska; M D Lambert
Amlodipine in elderly hypertensive patients: pharmacokinetics and pharmacodynamics.
Journal of cardiovascular pharmacology 1988;12 Suppl 7():S67-71.
1987: Darrell R. Abernethy; S C Montamat
Acute and chronic studies of diltiazem in elderly versus young hypertensive patients.
The American journal of cardiology 1987;60(17):116I-120I.
1987: R E Vestal; A J Wood; Darrell R. Abernethy; D H Solomon; D J Greenblatt
The concept of geriatric clinical pharmacology. Panel I: The ideal training program.
Clinical pharmacology and therapeutics 1987;42(6):696-701.
1987: Darrell R. Abernethy; P Bartos; J R Plachetka
Labetalol in the treatment of hypertension in elderly and younger patients.
Journal of clinical pharmacology 1987;27(11):902-6.
1987: J E Chelly; D C Hill; Darrell R. Abernethy; A Dlewati; M F Doursout; R G Merin
Pharmacodynamic and pharmacokinetic interactions between lidocaine and verapamil.
The Journal of pharmacology and experimental therapeutics 1987;243(1):211-6.
1987: Darrell R. Abernethy
Development of memory-enhancing agents in the treatment of Alzheimer's disease.
Journal of the American Geriatrics Society 1987;35(10):957-8.
1987: Darrell R. Abernethy; J B Schwartz; J R Plachetka; E L Todd; J M Egan
Comparison in young and elderly patients of pharmacodynamics and disposition of labetalol in systemic hypertension.
The American journal of cardiology 1987;60(8):697-702.
1987: J E Chelly; E S Hysing; D C Hill; Darrell R. Abernethy; A Dlewati; M F Doursout; R G Merin
Cardiovascular effects of and interaction between calcium blocking drugs and anesthetics in chronically instrumented dogs. V. Role of pharmacokinetics and the autonomic nervous system in the interactions between verapamil and inhalational anesthetics.
Anesthesiology 1987;67(3):320-5.
1987: S C Montamat; Darrell R. Abernethy
N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives.
British journal of clinical pharmacology 1987;24(2):185-9.
1987: J B Schwartz; Darrell R. Abernethy
Cardiac drugs: adjusting their use in aging patients.
Geriatrics 1987;42(8):31-4, 37-40.
1987: J E Chelly; E S Hysing; Darrell R. Abernethy; M F Doursout; Craig J Hartley; M Guerret; R G Merin
Role of isoflurane on hemodynamic properties and disposition of nicardipine.
The Journal of pharmacology and experimental therapeutics 1987;241(3):899-906.
1987: E L Todd; Darrell R. Abernethy
Physiological pharmacokinetics and pharmacodynamics of (+/-)-verapamil in female rats.
Biopharmaceutics & drug disposition 1987;8(3):285-97.
1987: J B Schwartz; Darrell R. Abernethy
Responses to intravenous and oral diltiazem in elderly and younger patients with systemic hypertension.
The American journal of cardiology 1987;59(12):1111-7.
1987: E B Nelson; J M Egan; Darrell R. Abernethy
The effect of propylene glycol on antipyrine clearance in humans.
Clinical pharmacology and therapeutics 1987;41(5):571-3.
1987: S C Montamat; Darrell R. Abernethy; J R Mitchell
High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma.
Journal of chromatography 1987;415(1):203-7.
1987: M I Charlat; P G O'Neill; J M Egan; Darrell R. Abernethy; Lloyd H Michael; M L Myers; Robert Roberts; Roberto Bolli
Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium.
The American journal of physiology 1987;252(3 Pt 2):H566-77.
1987: R G Merin; J E Chelly; E S Hysing; K Rogers; A Dlewati; Craig J Hartley; Darrell R. Abernethy; M F Doursout
Cardiovascular effects of and interaction between calcium blocking drugs and anesthetics in chronically instrumented dogs. IV. Chronically administered oral verapamil and halothane, enflurane, and isoflurane.
Anesthesiology 1987;66(2):140-6.
1986: Darrell R. Abernethy; D J Greenblatt; A Locniskar; H R Ochs; J S Harmatz; R I Shader
Obesity effects on nitrazepam disposition.
British journal of clinical pharmacology 1986;22(5):551-7.
1986: J E Chelly; E S Hysing; Darrell R. Abernethy; M F Doursout; R G Merin
Effects of inhalational anesthetics on verapamil pharmacokinetics in dogs.
Anesthesiology 1986;65(3):266-71.
1986: Darrell R. Abernethy; J B Schwartz; E L Todd; R Luchi; E Snow
Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses.
Annals of internal medicine 1986;105(3):329-36.
1986: G Carrum; Darrell R. Abernethy; M Sadhukhan; C E Wright
Minoxidil analysis in human plasma using high-performance liquid chromatography with electrochemical detection. Application to pharmacokinetic studies.
Journal of chromatography 1986;381(1):127-35.
1986: D J Greenblatt; Darrell R. Abernethy; H G Boxenbaum; R Matlis; H R Ochs; J S Harmatz; R I Shader
Influence of age, gender, and obesity on salicylate kinetics following single doses of aspirin.
Arthritis and rheumatism 1986;29(8):971-80.
1986: E L Todd; Darrell R. Abernethy
Pharmacokinetics and dynamics of (+/-)-verapamil in lean and obese Zucker rats.
The Journal of pharmacology and experimental therapeutics 1986;238(2):642-7.
1986: G Carrum; J M Egan; Darrell R. Abernethy
Diltiazem treatment impairs hepatic drug oxidation: studies of antipyrine.
Clinical pharmacology and therapeutics 1986;40(2):140-3.
1986: J M Egan; Darrell R. Abernethy
Lorazepam analysis using liquid chromatography: improved sensitivity for single-dose pharmacokinetic studies.
Journal of chromatography 1986;380(1):196-201.
1986: E B Nelson; Darrell R. Abernethy; D J Greenblatt; B Ameer
Paracetamol absorption from a feeding jejunostomy.
British journal of clinical pharmacology 1986;22(1):111-3.
1986: G T Blyden; Darrell R. Abernethy; D J Greenblatt
Ketoconazole does not impair antipyrine clearance in humans.
International journal of clinical pharmacology, therapy, and toxicology 1986;24(5):225-6.
1986: Darrell R. Abernethy; D J Greenblatt
Drug disposition in obese humans. An update.
Clinical pharmacokinetics 1986;11(3):199-213.
1986: Darrell R. Abernethy; E L Todd
Doxepin-cimetidine interaction: increased doxepin bioavailability during cimetidine treatment.
Journal of clinical psychopharmacology 1986;6(1):8-12.
1986: D J Greenblatt; Darrell R. Abernethy; R I Shader
Pharmacokinetic aspects of drug therapy in the elderly.
Therapeutic drug monitoring 1986;8(3):249-55.
1986: J B Schwartz; E Todd; Darrell R. Abernethy; J R Mitchell
Steady state verapamil tissue distribution in the dog: differing tissue accumulation.
Pharmacology 1986;32(6):307-12.
1986: H Friedman; Darrell R. Abernethy; D J Greenblatt; R I Shader
The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma.
Psychopharmacology 1986;88(3):267-70.
1986: Darrell R. Abernethy; D J Greenblatt; R I Shader
Benzodiazepine hypnotic metabolism: drug interactions and clinical implications.
Acta psychiatrica Scandinavica. Supplementum 1986;332():32-8.
1985: D J Greenblatt; Darrell R. Abernethy; A Locniskar; H R Ochs; J S Harmatz; R I Shader
Age, sex, and nitrazepam kinetics: relation to antipyrine disposition.
Clinical pharmacology and therapeutics 1985;38(6):697-703.
1985: Darrell R. Abernethy; D J Greenblatt
Ibuprofen disposition in obese individuals.
Arthritis and rheumatism 1985;28(10):1117-21.
1985: D S Morse; Darrell R. Abernethy; D J Greenblatt
Methodologic factors influencing plasma binding of alpha-1-acid glycoprotein-bound and albumin-bound drugs.
International journal of clinical pharmacology, therapy, and toxicology 1985;23(10):535-9.
1985: Darrell R. Abernethy; J B Schwartz; E L Todd
Lack of interaction between verapamil and cimetidine.
Clinical pharmacology and therapeutics 1985;38(3):342-9.
1985: Darrell R. Abernethy; D J Greenblatt; B Ameer; R I Shader
Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation.
The Journal of pharmacology and experimental therapeutics 1985;234(2):345-9.
1985: Darrell R. Abernethy; J B Schwartz; E L Todd
Diltiazem and desacetyldiltiazem analysis in human plasma using high-performance liquid chromatography: improved sensitivity without derivation.
Journal of chromatography 1985;342(1):216-20.
1985: Darrell R. Abernethy; E L Todd; J B Schwartz
Caffeine disposition in obesity.
British journal of clinical pharmacology 1985;20(1):61-6.
1985: J B Schwartz; A Taylor; Darrell R. Abernethy; M O'Meara; J Farmer; J Young; E Nelson; J Pool; J R Mitchell
Pharmacokinetics and pharmacodynamics of enalapril in patients with congestive heart failure and patients with hypertension.
Journal of cardiovascular pharmacology 1985;7(4):767-76.
1985: H R Ochs; D J Greenblatt; Darrell R. Abernethy; R M Arendt; J Gerloff; W Eichelkraut; N Hahn
Cerebrospinal fluid uptake and peripheral distribution of centrally acting drugs: relation to lipid solubility.
The Journal of pharmacy and pharmacology 1985;37(6):428-31.
1985: Darrell R. Abernethy; D J Greenblatt
Phenytoin disposition in obesity. Determination of loading dose.
Archives of neurology 1985;42(5):468-71.
1985: Darrell R. Abernethy; R M Arendt; D J Greenblatt
Pharmacologic properties of acebutolol: relationship of hydrophilicity to central nervous system penetration.
American heart journal 1985;109(5 Pt 2):1120-5.
1985: P Dorian; E M Sellers; H L Kaplan; C Hamilton; D J Greenblatt; Darrell R. Abernethy
Triazolam and ethanol interaction: kinetic and dynamic consequences.
Clinical pharmacology and therapeutics 1985;37(5):558-62.
1985: J B Schwartz; Darrell R. Abernethy; A A Taylor; J R Mitchell
An investigation of the cause of accumulation of verapamil during regular dosing in patients.
British journal of clinical pharmacology 1985;19(4):512-6.
1985: J A Martyn; D J Greenblatt; Darrell R. Abernethy
Increased cimetidine clearance in burn patients.
JAMA : the journal of the American Medical Association 1985;253(9):1288-91.
1985: Darrell R. Abernethy; E L Todd
Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives.
European journal of clinical pharmacology 1985;28(4):425-8.
1985: Darrell R. Abernethy; D J Greenblatt; R I Shader
Imipramine and desipramine disposition in the elderly.
The Journal of pharmacology and experimental therapeutics 1985;232(1):183-8.
1985: Darrell R. Abernethy; D J Greenblatt; D S Morse; R I Shader
Interaction of propoxyphene with diazepam, alprazolam and lorazepam.
British journal of clinical pharmacology 1985;19(1):51-7.
1984: D D Miller; L A Hershey; J P Duffy; Darrell R. Abernethy; D J Greenblatt
Serum haloperidol concentrations and clinical response in acute psychosis.
Journal of clinical psychopharmacology 1984;4(6):305-10.
1984: Darrell R. Abernethy; L Kerzner
Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding.
Journal of the American Geriatrics Society 1984;32(10):705-8.
1984: D J Greenblatt; Darrell R. Abernethy; R Matlis; J S Harmatz; R I Shader
Absorption and disposition of ibuprofen in the elderly.
Arthritis and rheumatism 1984;27(9):1066-9.
1984: D J Greenblatt; Darrell R. Abernethy; A Locniskar; J S Harmatz; R A Limjuco; R I Shader
Effect of age, gender, and obesity on midazolam kinetics.
Anesthesiology 1984;61(1):27-35.
1984: D J Greenblatt; Darrell R. Abernethy; D S Morse; J S Harmatz; R I Shader
Clinical importance of the interaction of diazepam and cimetidine.
The New England journal of medicine 1984;310(25):1639-43.
1984: Darrell R. Abernethy; D J Greenblatt; R I Shader
Imipramine disposition in users of oral contraceptive steroids.
Clinical pharmacology and therapeutics 1984;35(6):792-7.
1984: Darrell R. Abernethy; D J Greenblatt; R I Shader
Imipramine-cimetidine interaction: impairment of clearance and enhanced absolute bioavailability.
The Journal of pharmacology and experimental therapeutics 1984;229(3):702-5.
1984: C R Willis; D J Greenblatt; D M Benjamin; Darrell R. Abernethy
Simultaneous determination of lidocaine and its deethylated metabolites using gas-liquid chromatography with nitrogen-phosphorus detection.
Journal of chromatography 1984;307(1):200-5.
1984: Darrell R. Abernethy; D J Greenblatt; H R Ochs; C R Willis; D D Miller; R I Shader
Haloperidol determination in serum and cerebrospinal fluid using gas--liquid chromatography with nitrogen--phosphorus detection: application to pharmacokinetic studies.
Journal of chromatography 1984;307(1):194-9.
1984: J A Martyn; Darrell R. Abernethy; D J Greenblatt
Plasma protein binding of drugs after severe burn injury.
Clinical pharmacology and therapeutics 1984;35(4):535-9.
1984: Darrell R. Abernethy; D J Greenblatt
Lidocaine disposition in obesity.
The American journal of cardiology 1984;53(8):1183-6.
1984: D J Greenblatt; Darrell R. Abernethy; H H Koepke; R I Shader
Interaction of cimetidine with oxazepam, lorazepam, and flurazepam.
Journal of clinical pharmacology 1984;24(4):187-93.
1984: Darrell R. Abernethy; D J Greenblatt; R I Shader
Trimipramine kinetics and absolute bioavailability: use of gas-liquid chromatography with nitrogen-phosphorus detection.
Clinical pharmacology and therapeutics 1984;35(3):348-53.
1984: D J Greenblatt; Darrell R. Abernethy; M Divoll; A Locniskar; J S Harmatz; R I Shader
Noninteraction of temazepam and cimetidine.
Journal of pharmaceutical sciences 1984;73(3):399-401.
1984: Darrell R. Abernethy; D J Greenblatt; M Divoll; R B Smith; R I Shader
The influence of obesity on the pharmacokinetics of oral alprazolam and triazolam.
Clinical pharmacokinetics 1984;9(2):177-83.
1984: Darrell R. Abernethy; D J Greenblatt; R Matlis; R Gugler
Cimetidine disposition in obesity.
The American journal of gastroenterology 1984;79(2):91-4.
1984: Darrell R. Abernethy; D J Greenblatt; F N Eshelman; R I Shader
Ranitidine does not impair oxidative or conjugative metabolism: noninteraction with antipyrine, diazepam, and lorazepam.
Clinical pharmacology and therapeutics 1984;35(2):188-92.
1984: R G Lister; D J Greenblatt; Darrell R. Abernethy; S E File
Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.
Brain research 1984;290(1):183-6.
1984: H R Ochs; D J Greenblatt; B Verburg-Ochs; Darrell R. Abernethy; M Knüchel
Differential effects of isoniazid and oral contraceptive steroids on antipyrine oxidation and acetaminophen conjugation.
Pharmacology 1984;28(4):188-95.
1984: Darrell R. Abernethy; D J Greenblatt; R I Shader
Plasma levels of trazodone: methodology and applications.
Pharmacology 1984;28(1):42-6.
1984: Darrell R. Abernethy; E L Todd; J R Mitchell
Verapamil and norverapamil determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection: application to single-dose pharmacokinetic studies.
Pharmacology 1984;29(5):264-8.
1984: R M Arendt; D J Greenblatt; R H deJong; J D Bonin; Darrell R. Abernethy
Pharmacokinetics, central nervous system uptake, and lipid solubility of propranolol, acebutolol, and sotalol.
Cardiology 1984;71(6):307-14.
1984: D J Greenblatt; R I Shader; Darrell R. Abernethy
Anxiolytic drug therapy in patients with medical disease: clinical importance of pharmacokinetic drug interactions.
Psychopharmacology bulletin 1984;20(4):645-8.
1984: Darrell R. Abernethy; D J Greenblatt; H R Ochs; R I Shader
Benzodiazepine drug-drug interactions commonly occurring in clinical practice.
Current medical research and opinion 1984;8 Suppl 4():80-93.
1983: D J Greenblatt; Darrell R. Abernethy; M Divoll; H R Ochs; R I Shader
Antipyretic analgesic drugs as models for studies of drug disposition in old age.
The American journal of medicine 1983;75(5A):127-32.
1983: Darrell R. Abernethy; D J Greenblatt
Ibuprofen does not impair antipyrine clearance.
Journal of clinical pharmacology 1983;23(11-12):517-22.
1983: H R Vinik; Joseph Gerald Reves; D J Greenblatt; Darrell R. Abernethy; L R Smith
The pharmacokinetics of midazolam in chronic renal failure patients.
Anesthesiology 1983;59(5):390-4.
1983: Darrell R. Abernethy; D J Greenblatt
Impairment of lidocaine clearance in elderly male subjects.
Journal of cardiovascular pharmacology 1983;5(6):1093-6.
1983: R G Lister; Darrell R. Abernethy; D J Greenblatt; S E File
Methods for the determination of lorazepam and chlordiazepoxide and metabolites in brain tissue. A comparison with plasma concentrations in the rat.
Journal of chromatography 1983;277():201-8.
1983: D J Greenblatt; R M Arendt; Darrell R. Abernethy; H G Giles; E M Sellers; R I Shader
In vitro quantitation of benzodiazepine lipophilicity: relation to in vivo distribution.
British journal of anaesthesia 1983;55(10):985-9.
1983: R M Arendt; D J Greenblatt; R H deJong; J D Bonin; Darrell R. Abernethy; B L Ehrenberg; H G Giles; E M Sellers; R I Shader
In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution.
The Journal of pharmacology and experimental therapeutics 1983;227(1):98-106.
1983: D J Greenblatt; R I Shader; Darrell R. Abernethy
Drug therapy. Current status of benzodiazepines.
The New England journal of medicine 1983;309(7):410-6.
1983: D J Greenblatt; R I Shader; Darrell R. Abernethy
Drug therapy. Current status of benzodiazepines.
The New England journal of medicine 1983;309(6):354-8.
1983: H R Ochs; D J Greenblatt; R Gugler; G Müntefering; A Locniskar; Darrell R. Abernethy
Cimetidine impairs nitrazepam clearance.
Clinical pharmacology and therapeutics 1983;34(2):227-30.
1983: B Ameer; M Divoll; Darrell R. Abernethy; D J Greenblatt; L Shargel
Absolute and relative bioavailability of oral acetaminophen preparations.
Journal of pharmaceutical sciences 1983;72(8):955-8.
1983: Darrell R. Abernethy; D J Greenblatt
Diphenhydramine determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection: application to single low-dose pharmacokinetic studies.
Journal of pharmaceutical sciences 1983;72(8):941-3.
1983: Darrell R. Abernethy; D J Greenblatt; M Divoll; R I Shader
Prolonged accumulation of diazepam in obesity.
Journal of clinical pharmacology 1983;23(8-9):369-76.
1983: D J Greenblatt; Darrell R. Abernethy; M Divoll
Is volume of distribution at steady state a meaningful kinetic variable?
Journal of clinical pharmacology 1983;23(8-9):391-400.
1983: Darrell R. Abernethy; D J Greenblatt; M Divoll; R I Shader
Pharmacokinetics of alprazolam.
The Journal of clinical psychiatry 1983;44(8 Pt 2):45-7.
1983: D J Greenblatt; R Matlis; Darrell R. Abernethy; H R Oche
Improved liquid chromatographic analysis of phenytoin and salicylate using radial compression separation.
Journal of chromatography 1983;275(2):450-7.
1983: H R Ochs; U Schuppan; D J Greenblatt; Darrell R. Abernethy
Reduced distribution and clearance of acetaminophen in patients with congestive heart failure.
Journal of cardiovascular pharmacology 1983;5(4):697-9.
1983: Darrell R. Abernethy; D J Greenblatt; M Divoll; R I Shader
Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen.
The Journal of laboratory and clinical medicine 1983;101(6):873-80.
1983: D J Greenblatt; M Divoll; Darrell R. Abernethy; H R Ochs; R I Shader
Clinical pharmacokinetics of the newer benzodiazepines.
Clinical pharmacokinetics 1983;8(3):233-52.
1983: Darrell R. Abernethy; D J Greenblatt; H R Ochs; D Weyers; M Divoll; J S Harmatz; R I Shader
Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives.
Clinical pharmacology and therapeutics 1983;33(5):628-32.
1983: L Labedzki; H R Ochs; Darrell R. Abernethy; D J Greenblatt
Potentially toxic serum lidocaine concentrations following spray anesthesia for bronchoscopy.
Klinische Wochenschrift 1983;61(7):379-80.
1983: H R Ochs; M Knüchel; Darrell R. Abernethy; D J Greenblatt
Dose-independent pharmacokinetics of intravenous lidocaine in humans.
Journal of clinical pharmacology 1983;23(4):186-8.
1983: D J Greenblatt; Darrell R. Abernethy; M Divoll; J S Harmatz; R I Shader
Pharmacokinetic properties of benzodiazepine hypnotics.
Journal of clinical psychopharmacology 1983;3(2):129-32.
1983: Darrell R. Abernethy; D J Greenblatt; M Divoll; B Ameer; R I Shader
Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine.
The Journal of pharmacology and experimental therapeutics 1983;224(3):508-13.
1983: D J Greenblatt; M Divoll; Darrell R. Abernethy; L J Moschitto; R B Smith; R I Shader
Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity.
British journal of clinical pharmacology 1983;15(3):303-9.
1983: D J Greenblatt; M Divoll; Darrell R. Abernethy; L J Moschitto; R B Smith; R I Shader
Alprazolam kinetics in the elderly. Relation to antipyrine disposition.
Archives of general psychiatry 1983;40(3):287-90.
1983: D J Greenblatt; Darrell R. Abernethy; M Divoll
Kinetics of low-dose intravenous antipyrine: use of liquid chromatography.
International journal of clinical pharmacology, therapy, and toxicology 1983;21(2):51-5.
1983: H R Ochs; D Skanderra; Darrell R. Abernethy; D J Greenblatt
Effect of penbutolol on lidocaine kinetics.
Arzneimittel-Forschung 1983;33(12):1680-1.
1983: D J Greenblatt; Darrell R. Abernethy; M Divoll; R I Shader
Close correlation of acetaminophen clearance with that of conjugated benzodiazepines but not oxidized benzodiazepines.
European journal of clinical pharmacology 1983;25(1):113-5.
1983: Darrell R. Abernethy; R M Arendt; P M Lauven; D J Greenblatt
Determination of Ro 15-1788, a benzodiazepine antagonist, in human plasma by gas-liquid chromatography with nitrogen-phosphorus detection. Application to single-dose pharmacokinetic studies.
Pharmacology 1983;26(5):285-9.
1983: D J Greenblatt; M Divoll; Darrell R. Abernethy; H R Ochs; R I Shader
Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics.
Drug metabolism reviews 1983;14(2):251-92.
1983: D J Greenblatt; M Divoll; Darrell R. Abernethy; A Locniskar; R I Shader
Pharmacokinetics of benzodiazepine hypnotics.
Pharmacology 1983;27 Suppl 2():70-5.
1983: Darrell R. Abernethy; D J Greenblatt; M Divoll; L J Moschitto; J S Harmatz; R I Shader
Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam.
Psychopharmacology 1983;80(3):275-8.
1982: M Divoll; D J Greenblatt; B Ameer; Darrell R. Abernethy
Effect of food on acetaminophen absorption in young and elderly subjects.
Journal of clinical pharmacology 1982;22(11-12):571-6.
1982: D J Greenblatt; M Divoll; Darrell R. Abernethy; R I Shader
Physiologic changes in old age: relation to altered drug disposition.
Journal of the American Geriatrics Society 1982;30(11 Suppl):S6-10.
1982: M Divoll; D J Greenblatt; Darrell R. Abernethy; R I Shader
Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly.
Journal of the American Geriatrics Society 1982;30(11):684-9.
1982: Darrell R. Abernethy; D J Greenblatt; H R Ochs
Lidocaine determination in human plasma with application to single low-dose pharmacokinetic studies.
Journal of chromatography 1982;232(1):180-5.
1982: Darrell R. Abernethy; M Divoll; H R Ochs; B Ameer; D J Greenblatt
Increased metabolic clearance of acetaminophen with oral contraceptive use.
Obstetrics and gynecology 1982;60(3):338-41.
1982: Darrell R. Abernethy; D J Greenblatt; K Steel; R I Shader
Impairment of hepatic drug oxidation by propoxyphene.
Annals of internal medicine 1982;97(2):223-4.
1982: Darrell R. Abernethy; D J Greenblatt; M Divoll; R I Shader
Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate).
Journal of pharmaceutical sciences 1982;71(8):942-4.
1982: Darrell R. Abernethy; M Divoll; D J Greenblatt; B Ameer
Obesity, sex, and acetaminophen disposition.
Clinical pharmacology and therapeutics 1982;31(6):783-90.
1982: M Divoll; B Ameer; Darrell R. Abernethy; D J Greenblatt
Age does not alter acetaminophen absorption.
Journal of the American Geriatrics Society 1982;30(4):240-4.
1982: Darrell R. Abernethy; D J Greenblatt; M Divoll; R Arendt; H R Ochs; R I Shader
Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids.
The New England journal of medicine 1982;306(13):791-2.
1982: Darrell R. Abernethy; D J Greenblatt
Pharmacokinetics of drugs in obesity.
Clinical pharmacokinetics 1982;7(2):108-24.
1982: M Divoll; Darrell R. Abernethy; B Ameer; D J Greenblatt
Acetaminophen kinetics in the elderly.
Clinical pharmacology and therapeutics 1982;31(2):151-6.
1982: D J Greenblatt; M Divoll; Darrell R. Abernethy; J S Harmatz; R I Shader
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.
The Journal of pharmacology and experimental therapeutics 1982;220(1):120-6.
1982: D J Greenblatt; M Divoll; Darrell R. Abernethy; A Locniskar; R I Shader
Pharmacokinetics of benzodiazepine hypnotics.
International pharmacopsychiatry 1982;17 Suppl 2():70-5.
1982: D J Greenblatt; M Divoll; Darrell R. Abernethy; R I Shader
Benzodiazepine hypnotics: kinetic and therapeutic options.
Sleep 1982;5 Suppl 1():S18-27.
1981: H R Ochs; D J Greenblatt; H J Kaschell; U Klehr; M Divoll; Darrell R. Abernethy
Diazepam kinetics in patients with renal insufficiency or hyperthyroidism.
British journal of clinical pharmacology 1981;12(6):829-32.
1981: B Ameer; D J Greenblatt; M Divoll; Darrell R. Abernethy; L Shargel
High-performance liquid chromatographic determination of acetaminophen in plasma: single-dose pharmacokinetic studies.
Journal of chromatography 1981;226(1):224-30.
1981: Darrell R. Abernethy; D J Greenblatt; T W Smith
Digoxin disposition in obesity: clinical pharmacokinetic investigation.
American heart journal 1981;102(4):740-4.
1981: Darrell R. Abernethy; D J Greenblatt; M Divoll; J S Harmatz; R I Shader
Alterations in drug distribution and clearance due to obesity.
The Journal of pharmacology and experimental therapeutics 1981;217(3):681-5.
1981: Darrell R. Abernethy; D J Greenblatt
Effects of desmethyldiazepam on diazepam kinetics: a study of effects of a metabolite on parent drug disposition.
Clinical pharmacology and therapeutics 1981;29(6):757-61.
1981: Darrell R. Abernethy; D J Greenblatt; A M Zumbo
Antipyrine determination in human plasma by gas--liquid chromatography using nitrogen--phosphorus detection.
Journal of chromatography 1981;223(2):432-7.
1981: Darrell R. Abernethy; D J Greenblatt; R I Shader
Treatment of diazepam withdrawal syndrome with propranolol.
Annals of internal medicine 1981;94(3):354-5.
1981: Darrell R. Abernethy; D J Greenblatt
Impairment of antipyrine metabolism by low-dose oral contraceptive steroids.
Clinical pharmacology and therapeutics 1981;29(1):106-10.
1981: Darrell R. Abernethy; D J Greenblatt; R I Shader
Tricyclic antidepressant determination in human plasma by gas-liquid chromatography using nitrogen-phosphorous detection: application to single-dose pharmacokinetic studies.
Pharmacology 1981;23(2):57-63.
1981: H R Ochs; D J Greenblatt; M Divoll; Darrell R. Abernethy; H Feyerabend; H J Dengler
Diazepam kinetics in relation to age and sex.
Pharmacology 1981;23(1):24-30.
1978: S H Preskorn; Darrell R. Abernethy; W V McKnelly
Use of saliva lithium determinations for monitoring lithium therapy.
The Journal of clinical psychiatry 1978;39(10):756-8.
1977: Darrell R. Abernethy; D L Azarnoff
Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis.
Biochemical pharmacology 1977;26(6):481-4.
1974: Darrell R. Abernethy; T J Fitzgerald; E J Walaszek
NMR investigation of histamine-phospholipid interaction.
Biochemical and biophysical research communications 1974;59(2):535-41.
1972: E E Smissman; J W Ayres; P J Wirth; Darrell R. Abernethy
The synthesis of 2,4-diketo-5-phenyl- 5 -7-oxa-1,3-diazabicyclo(4.4.0)decane and 2,4-diketo-3-phenyl- 5 -7-oxa-1,5-diazabicyclo(4.4.0)decane.
The Journal of organic chemistry 1972;37(22):3486-8.