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Thomas Hartung

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TOP 3
Marcel Leist; Thomas Hartung
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.
Myrtle Davis; Gary Eichenbaum; Thomas Hartung; Michael P Holsapple; Thomas W Jones; Ann M Richard; Kim Boekelheide; Darrell R Boverhof; Paul B Watkins
The new revolution in toxicology: the good, the bad, and the ugly.
Marcel Leist; Thomas Hartung
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.

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All Publications

2013: Marcel Leist; Thomas Hartung
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.
Archives of toxicology 2013;87(4):563-7.
2013: Myrtle Davis; Gary Eichenbaum; Thomas Hartung; Michael P Holsapple; Thomas W Jones; Ann M Richard; Kim Boekelheide; Darrell R Boverhof; Paul B Watkins
The new revolution in toxicology: the good, the bad, and the ugly.
Annals of the New York Academy of Sciences 2013;1278():11-24.
2013: Marcel Leist; Thomas Hartung
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.
ALTEX 2013;30(2):227-30.
2013: Nina Hasiwa; Astrid Hochadel; Sebastian Hoffmann; Felix E Rivera-Mariani; Christoph Rockel; Stefanie Schindler; Ingo Spreitzer; Sandra Stoppelkamp; Kranthi Vysyaraju; Peter Bruegger; Mardas Daneshian; Stefan Fennrich; Thomas Hartung
Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test.
ALTEX 2013;30(2):169-208.
2013: Thomas Hartung; Sebastian Hoffmann; Martin Stephens
Mechanistic validation.
ALTEX 2013;30(2):119-30.
2013: Martin L Stephens; Douglas Wolf; Melvin Andersen; Richard A Becker; kellyn betts; Kim Boekelheide; Ed Carney; Robert Chapin; Dennis Devlin; Suzanne Fitzpatrick; John R Fowle; Patricia Harlow; Thomas Hartung; Sebastian Hoffmann; Michael Holsapple; Abigail Jacobs; Richard Judson; Olga Naidenko; Tim Pastoor; Grace Patlewicz; Andrew Rowan; Roberta Scherer; Rashid Shaikh; Ted Simon; Joanne Zurlo
Evidence-based toxicology for the 21st century: opportunities and challenges.
ALTEX 2013;30(1):74-103.
2013: Richard Judson; Robert Kavlock; Thomas Knudsen; Matthew Martin; David Reif; Ann Richard; Raymond R Tice; Weida Tong; Maurice Whelan; William Wooge; Menghang Xia; John R Fowle; Thomas Hartung; Keith Houck; Ruili Huang; Christopher P Austin; George Daston; David Dix
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.
ALTEX 2013;30(1):51-6.
2013: Thomas Hartung; Tom Luechtefeld; Alexandra Maertens; Andre Kleensang
Integrated testing strategies for safety assessments.
ALTEX 2013;30(1):3-18.
2012: Gian Paolo Rossini; Thomas Hartung
Towards tailored assays for cell-based approaches to toxicity testing.
ALTEX 2012;29(4):359-72.
2012: Thomas Hartung; Joanne Zurlo
Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare.
ALTEX 2012;29(3):251-60.
2012: Thomas Hartung; Joanna Jaworska; Nigel Skinner; Leo Bonilla; Erwin van Vliet; Russell Thomas
Systems toxicology.
ALTEX 2012;29(2):119-28.
2012: Christoph Rockel; Thomas Hartung
Systematic review of membrane components of gram-positive bacteria responsible as pyrogens for inducing human monocyte/macrophage cytokine release.
Frontiers in pharmacology 2012;3():56.
2012: David A Basketter; Bas Blaauboer; Robert Burrier; Harvey Clewell; Mardas Daneshian; Chantra Eskes; Alan M Goldberg; Nina Hasiwa; Sebastian Hoffmann; Joanna Jaworska; Ian Kimber; Thomas B Knudsen; Robert Landsiedel; Marcel Leist; PAUL LOCKE; Gavin Maxwell; James McKim; Emily A McVey; Gladys Ouédraogo; Grace Patlewicz; Olavi Pelkonen; Erwin Roggen; Annamaria Rossi; Costanza Rovida; Irmela Ruhdel; Andreas Schepky; Greet Schoeters; Michael Schwarz; Nigel Skinner; Kerstin Trentz; Marian Turner; Philippe Vanparys; James D Yager; Joanne Zurlo; Thomas Hartung
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.
ALTEX 2012;29(1):3-91.
2011: Lothar Lindemann; Aubin Michalon; Neil Parrott; Richard Porter; Eric P M Prinssen; Will Spooren; Eric Vieira; Bernd Büttelmann; Catherine Diener; Christophe Fischer; Christophe Flament; Silvia Gatti; Thomas Hartung; Gerhard Hoffmann; Michael Honer; Georg Jaeschke; Sabine Kolczewski; Joseph G Wettstein
CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.
The Journal of pharmacology and experimental therapeutics 2011;339(2):474-86.
2011: Thomas Hartung
From alternative methods to a new toxicology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;77(3):338-49.
2011: Christoph Rockel; Thomas Hartung; Corinna Hermann
Different Staphylococcus aureus whole bacteria mutated in putative pro-inflammatory membrane components have similar cytokine inducing activity.
Immunobiology 2011;216(3):316-21.
2011: Mardas Daneshian; Alan M Goldberg; Franz Gruber; Thomas Hartung; Mohammad A Akbarsha; Bas J Blaauboer; Francesca Caloni; Pierre Cosson; rodger curren; frauke ohl; Walter Pfaller; Jan van der Valk; Pilar Vinardell; Joanne Zurlo; Marcel Leist
A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation.
ALTEX 2011;28(4):341-52.
2011: Nina Hasiwa; Robert Hubrecht; Werner Kobel; Goran Krummenacher; Marcel Leist; Hannes Lohi; Adám Miklósi; frauke ohl; Klaus Olejniczak; Georg Schmitt; Patrick Sinnett-Smith; David Smith; Kristina Wagner; James D Yager; Joanne Zurlo; Jarrod Bailey; Peter Clausing; Mardas Daneshian; Marianne Eileraas; Sándor Farkas; István Gyertyán; Thomas Hartung
Critical evaluation of the use of dogs in biomedical research and testing in Europe.
ALTEX 2011;28(4):326-40.
2011: Ellen K Silbergeld; Robert Tanguay; Norihasa Tatarazako; Erwin van Vliet; Nigel J Walker; Mark Wiesner; Neil Wilcox; Elizabeth Q Contreras; Andrea de Vizcaya Ruiz; Thomas Hartung; Cordula Hirsch; Helena Hogberg; Ashish C Jachak; William Jordan; Robert LANDSIEDEL; Jeffery Morris; Anil Patri; Joel G Pounds; Anna Shvedova; Joanne Zurlo
t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.
ALTEX 2011;28(3):236-41.
2011: Thomas Hartung; Makoto Hayashi; Jan G Hengstler; Lisbeth E Knudsen; Thomas B Knudsen; James M McKim; Walter Pfaller; Bas J Blaauboer; Sieto Bosgra; Edward Carney; Joachim Coenen; Rory B Conolly; Emanuela Corsini; Elaine M Faustman; Anthony Gaspari; Sidney Green; A Wallace Hayes; Erwin L Roggen
An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".
ALTEX 2011;28(3):183-209.
2011: Thomas Hartung; Mary McBride
Food for Thought ... on mapping the human toxome.
ALTEX 2011;28(2):83-93.
2011: Oliver Dehus; Markus Pfitzenmaier; Gunthard Stuebs; Natalie Fischer; Wilhelm J Schwaeble; Siegfried Morath; Thomas Hartung; Armin Geyer; Corinna Hermann
Growth temperature-dependent expression of structural variants of Listeria monocytogenes lipoteichoic acid.
Immunobiology 2011;216(1-2):24-31.
2010: Sebastian Bunk; Stefanie Sigel; Daniela Metzdorf; Omar Sharif; Kathy Triantafilou; Martha Triantafilou; Thomas Hartung; Sylvia Knapp; Sonja Von Aulock
Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3708-17.
2010: Anna K Bal-Price; Helena T Hogberg; Leonora Buzanska; Petros Lenas; Erwin van Vliet; Thomas Hartung
In vitro developmental neurotoxicity (DNT) testing: relevant models and endpoints.
Neurotoxicology 2010;31(5):545-54.
2010: David A Basketter; Ian Kimber; Thomas Hartung
The evolution of validation: a commentary.
Cutaneous and ocular toxicology 2010;29(1):1-3.
2010: Thomas Hartung
Lessons learned from alternative methods and their validation for a new toxicology in the 21st century.
Journal of toxicology and environmental health. Part B, Critical reviews 2010;13(2-4):277-90.
2010: Laurie Scott; Chantra Eskes; Sebastian Hoffmann; Els Adriaens; Nathalie Alepée; Monica Bufo; Richard H Clothier; Davide Facchini; Claudine Faller; Robert Guest; John Harbell; Thomas Hartung; Hennicke Kamp; Béatrice Le Varlet; Marisa Meloni; Pauline McNamee; Rosemarie Osborne; Wolfgang Pape; Uwe Pfannenbecker; Menk Prinsen; Christopher Seaman; Horst Spielmann; William S Stokes; Kevin Trouba; Christine Van den Berghe; Freddy Van Goethem; Marco Vassallo; Pilar Vinardell; Valérie Zuang
A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Toxicology in vitro : an international journal published in association with BIBRA 2010;24(1):1-9.
2010: Thomas Hartung
Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC - a t4 report.
ALTEX 2010;27(4):285-303.
2010: Thomas Hartung
Evidence-based toxicology - the toolbox of validation for the 21st century?
ALTEX 2010;27(4):253-63.
2010: Thomas Hartung
Food for thought ... on alternative methods for nanoparticle safety testing.
ALTEX 2010;27(2):87-95.
2010: Mardas Daneshian; Marcel Leist; Thomas Hartung
The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology.
ALTEX 2010;27(1):63-9.
2010: Thomas Hartung; Leon Bruner; rodger curren; Chantra Eskes; Alan M Goldberg; Pauline McNamee; Laurie Scott; Valérie Zuang
First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain.
ALTEX 2010;27(1):43-51.
2010: Thomas Hartung
Food for thought...on alternative methods for chemical safety testing.
ALTEX 2010;27(1):3-14.
2010: Efrat Forti; Anna Bulgheroni; Yuksel Cetin; Thomas Hartung; Paul Jennings; Walter Pfaller; Pilar Prieto
Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(1):159-68.
2010: Helena T Hogberg; Agnieszka Kinsner-Ovaskainen; Sandra Coecke; Thomas Hartung; Anna K Bal-Price
mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach.
Toxicological sciences : an official journal of the Society of Toxicology 2010;113(1):95-115.
2009: Thomas Hartung
Per aspirin ad astra...
Alternatives to laboratory animals : ATLA 2009;37 Suppl 2():45-7.
2009: Agnieszka Kinsner-Ovaskainen; Anna Bulgheroni; Thomas Hartung; Pilar Prieto
ECVAM's ongoing activities in the area of acute oral toxicity.
Toxicology in vitro : an international journal published in association with BIBRA 2009;23(8):1535-40.
2009: Thomas Hartung; George Daston
Are in vitro tests suitable for regulatory use?
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):233-7.
2009: Klaus Schneider; Markus Schwarz; Iris Burkholder; Annette Kopp-Schneider; Lutz Edler; Agnieszka Kinsner-Ovaskainen; Thomas Hartung; Sebastian Hoffmann
"ToxRTool", a new tool to assess the reliability of toxicological data.
Toxicology letters 2009;189(2):138-44.
2009: Thomas Hartung; Costanza Rovida
Chemical regulators have overreached.
Nature 2009;460(7259):1080-1.
2009: Thomas Hartung
Toxicology for the twenty-first century.
Nature 2009;460(7252):208-12.
2009: Daniele Ferrario; Angelo Collotta; Maria Carfi; Gerard Bowe; Marie Vahter; Thomas Hartung; Laura Gribaldo
Arsenic induces telomerase expression and maintains telomere length in human cord blood cells.
Toxicology 2009;260(1-3):132-41.
2009: Thomas Hartung
A toxicology for the 21st century--mapping the road ahead.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):18-23.
2009: Nigel Moore; Susanne Bremer; Neil Carmichael; George Daston; Matt Dent; Wassila Gaoua-Chapelle; Nina Hallmark; Thomas Hartung; Beate Holzum; Ulrich Hübel; Marie-Louise Meisters; Steffen Schneider; Bennard van Ravenzwaay; Christa Hennes
A modular approach to the extended one-generation reproduction toxicity study. The outcome of an ECETOC Task Force and International ECETOC/ECVAM Workshop.
Alternatives to laboratory animals : ATLA 2009;37(2):219-25.
2009: Helena T Hogberg; Agnieszka Kinsner-Ovaskainen; Thomas Hartung; Sandra Coecke; Anna K Bal-Price
Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides.
Toxicology and applied pharmacology 2009;235(3):268-86.
2009: Agnieszka Kinsner; C Griesinger; S Hoffmann; S Coecke; G Bowe; C Campana; Thomas Hartung
5.6 An online portal to evidence-based toxicology.
Human & experimental toxicology 2009;28(2-3):161.
2009: C Griesinger; S Hoffmann; Agnieszka Kinsner; S Coecke; Thomas Hartung
5.4 Possible improvement of information sources on hazard and risk.
Human & experimental toxicology 2009;28(2-3):157.
2009: C Griesinger; S Hoffmann; Agnieszka Kinsner; S Coecke; Thomas Hartung
5.3 Evidence-based tools in toxicological decision-making.
Human & experimental toxicology 2009;28(2-3):155.
2009: C Griesinger; S Hoffmann; Agnieszka Kinsner; S Coecke; Thomas Hartung
5.2 Evidence-based tools in toxicological hazard identification.
Human & experimental toxicology 2009;28(2-3):153.
2009: C Griesinger; S Hoffmann; Agnieszka Kinsner; S Coecke; Thomas Hartung
5 Steps toward an evidence-based toxicology: 5.1 evidence-based tools in toxicological basic research.
Human & experimental toxicology 2009;28(2-3):151.
2009: C Griesinger; S Hoffmann; Agnieszka Kinsner; S Coecke; Thomas Hartung
4.9 Current information sources for hazard identification.
Human & experimental toxicology 2009;28(2-3):149.
2009: C Griesinger; S Hoffmann; Agnieszka Kinsner; S Coecke; Thomas Hartung
4.8 Current schemes for decision-making in toxicology.
Human & experimental toxicology 2009;28(2-3):147.
2009: Thomas Hartung
1 Fundamentals of a an evidence-based toxicology: 1.1 opening statement.
Human & experimental toxicology 2009;28(2-3):93-4.
2009: C Griesinger; S Hoffmann; Agnieszka Kinsner; S Coecke; Thomas Hartung
Special issue: Evidence-based toxicology (EBT). Preface.
Human & experimental toxicology 2009;28(2-3):83-6.
2009: Anna Bulgheroni; Agnieszka Kinsner-Ovaskainen; Sebastian Hoffmann; Thomas Hartung; Pilar Prieto
Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats.
Regulatory toxicology and pharmacology : RTP 2009;53(1):16-9.
2009: Thomas Hartung; Costanza Rovida
That which must not, can not be... A reply to the EChA and EDF responses to the REACH analysis of animal use and costs.
ALTEX 2009;26(4):307-11.
2009: Chantra Eskes; Vanessa de Moura Sá-Rocha; Jadir Nunes; Octavio Presgrave; Dermeval de Carvalho; Philippe Masson; Ekaterina Rivera; Sandra Coecke; Joachim Kreysa; Thomas Hartung
Proposal for a Brazilian centre on alternative test methods.
ALTEX 2009;26(4):303-6.
2009: Stefanie Schindler; Sonja Von Aulock; Mardas Daneshian; Thomas Hartung
Development, validation and applications of the monocyte activation test for pyrogens based on human whole blood.
ALTEX 2009;26(4):265-77.
2009: Thomas Hartung; Bas Blaauboer; Marcel Leist
Food for thought ... on education in alternative methods in toxicology.
ALTEX 2009;26(4):255-63.
2009: Costanza Rovida; Thomas Hartung
Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t(4)).
ALTEX 2009;26(3):187-208.
2009: Thomas Hartung; Sebastian Hoffmann
Food for thought ... on in silico methods in toxicology.
ALTEX 2009;26(3):155-66.
2009: Mardas Daneshian; Sonja Von Aulock; Thomas Hartung
Assessment of pyrogenic contaminations with validated human whole-blood assay.
Nature protocols 2009;4(12):1709-21.
2009: Thomas Hartung
Food for thought... on evidence-based toxicology.
ALTEX 2009;26(2):75-82.
2009: Annamaria A Bottini; Thomas Hartung
Food for thought... on the economics of animal testing.
ALTEX 2009;26(1):3-16.
2009: Obaidur Rahman; Markus Pfitzenmaier; Oxana Pester; Siegfried Morath; Stephen P Cummings; Thomas Hartung; Iain C Sutcliffe
Macroamphiphilic components of thermophilic actinomycetes: identification of lipoteichoic acid in Thermobifida fusca.
Journal of bacteriology 2009;191(1):152-60.
2008: Thomas Hartung
Toward a new toxicology - evolution or revolution?
Alternatives to laboratory animals : ATLA 2008;36(6):635-9.
2008: Robert Bucki; Fitzroy J Byfield; Alina Kulakowska; Margaret E McCormick; Wieslaw Drozdowski; Zbigniew Namiot; Thomas Hartung; Paul A Janmey
Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4936-44.
2008: Hans-Jürgen Ahr; Nathalie Alepée; Siegfried Breier; Cornelis Brekelmans; Ian Cotgreave; Laura Gribaldo; Gianni Dal Negro; Odile De Silva; Thomas Hartung; Antonio Lacerda; Bernard Leblanc; Catherine Lecerf; Jens P Linge; Susanna Louhimies; Irene Manou; Gavin Maxwell; Karsten K Müller; Wolfgang Pape; Keith Redhead; Klaus R Schröder; Dariusz Sladowski; Katinka van der Jagt; Phillipe Vanparys
Barriers to validation: a report by the European Partnership fo Alternative Approaches to Animal Testing (EPAA) Working Group 5.
Alternatives to laboratory animals : ATLA 2008;36(4):459-64.
2008: Mardas Daneshian; Albrecht Wendel; Thomas Hartung; Sonja Von Aulock
High sensitivity pyrogen testing in water and dialysis solutions.
Journal of immunological methods 2008;336(1):64-70.
2008: Annamaria A Bottini; Natalie Alepee; Barry Phillips; Laura Gribaldo; Odile De Silva; Thomas Hartung; Coenraad Hendriksen; Janne Kuil; Patricia Pazos; Cornelius Rhein; Marie-Jeanne Schiffelers; William Stokes; Anne Theobald; Jean-Marc Vidal; Han Van de Sandt; Siegfried Breier; Juan R Sintes; Bas J Blaauboer
Optimisation of the post-validation process: the report and recommendations of ECVAM Workshop 67.
Alternatives to laboratory animals : ATLA 2008;36(3):353-66.
2008: Sebastian Hoffmann; Lutz Edler; Ian Gardner; Laura Gribaldo; Thomas Hartung; Christoph Klein; Manfred Liebsch; Stefan Sauerland; Leonard M Schechtman; Annalaura Stammati; Efstathios Nikolaidis
Points of reference in the validation process: the report and recommendations of ECVAM Workshop 66.
Alternatives to laboratory animals : ATLA 2008;36(3):343-52.
2008: Nadra Nilsen; Susanne Deininger; Unni Nonstad; Frode Skjeldal; Harald Husebye; Dmitrii Rodionov; Sonja Von Aulock; Thomas Hartung; Egil Lien; Oddmund Bakke; Terje Espevik
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36.
Journal of leukocyte biology 2008;84(1):280-91.
2008: Raffaella Corvi; Silvio Albertini; Thomas Hartung; Sebastian Hoffmann; Daniela Maurici; Stefan Pfuhler; Jan van Benthem; Philippe Vanparys
ECVAM retrospective validation of in vitro micronucleus test (MNT).
Mutagenesis 2008;23(4):271-83.
2008: Naomi E Kramer; Hester E Hasper; Patrick T C van den Bogaard; Siegfried Morath; Ben de Kruijff; Thomas Hartung; Eddy J. Smid; Eefjan Breukink; Jan Kok; Oscar P Kuipers
Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis.
Microbiology (Reading, England) 2008;154(Pt 6):1755-62.
2008: Marina Hasiwa; Ondrej Kylián; Thomas Hartung; Francois Rossi
Removal of immune-stimulatory components from surfaces by plasma discharges.
Innate immunity 2008;14(2):89-97.
2008: Mario Di Gioacchino; Claudia Petrarca; Angela Perrone; Massimo Farina; Enrico Sabbioni; Thomas Hartung; Simone Martino; Diana L Esposito; Lavinia Vittoria Lotti; Renato Mariani-Costantini
Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells.
The Science of the total environment 2008;392(1):50-8.
2008: Christian Draing; Stephanie Traub; Susanne Deininger; Philippa Mang; Heiko M Möller; Miguel Manso; Francois Rossi; Siegfried Morath; Thomas Hartung; Sonja Von Aulock
Polypropylene glycol is a selective binding inhibitor for LTA and other structurally related TLR2 agonists.
European journal of immunology 2008;38(3):797-808.
2008: Sarah Adler; Cristian Pellizzer; Lars Hareng; Thomas Hartung; Susanne Bremer
First steps in establishing a developmental toxicity test method based on human embryonic stem cells.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(1):200-11.
2008: Thomas Hartung; Herman Koeter
Food for thought ... On food safety testing.
ALTEX 2008;25(4):259-64.
2008: Thomas Hartung
Food for thought ... on alternative methods for cosmetics safety testing.
ALTEX 2008;25(3):147-62.
2008: Thomas Hartung
Thoughts on limitations of animal models.
Parkinsonism & related disorders 2008;14 Suppl 2():S81-3.
2008: Marcel Leist; Thomas Hartung; Pierluigi Nicotera
The dawning of a new age of toxicology.
ALTEX 2008;25(2):103-14.
2008: Thomas Hartung; Marcel Leist
Food for thought ... on the evolution of toxicology and the phasing out of animal testing.
ALTEX 2008;25(2):91-102.
2008: Susanne Deininger; Stephanie Traub; Diana Aichele; Tamara Rupp; Teodora Baris; Heiko M Möller; Thomas Hartung; Sonja Von Aulock
Presentation of lipoteichoic acid potentiates its inflammatory activity.
Immunobiology 2008;213(6):519-29.
2008: Christian Draing; Stefanie Sigel; Susanne Deininger; Stephanie Traub; Rebekka Munke; Christoph Mayer; Lars Hareng; Thomas Hartung; Sonja Von Aulock; Corinna Hermann
Cytokine induction by Gram-positive bacteria.
Immunobiology 2008;213(3-4):285-96.
2008: Thomas Hartung
Food for thought... on animal tests.
ALTEX 2008;25(1):3-16.
2008: Eva Mattsson; Ruth Heying; Joke S van de Gevel; Thomas Hartung; Henry Beekhuizen
Staphylococcal peptidoglycan initiates an inflammatory response and procoagulant activity in human vascular endothelial cells: a comparison with highly purified lipoteichoic acid and TSST-1.
FEMS immunology and medical microbiology 2008;52(1):110-7.
2008: Erwin van Vliet; Siegfried Morath; Chantra Eskes; Jens Linge; Juri Rappsilber; Paul Honegger; Thomas Hartung; Sandra Coecke
A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine.
Neurotoxicology 2008;29(1):1-12.
2007: Michel Bouvier d'Yvoire; Pilar Prieto; Bas J Blaauboer; Frederic Yves Bois; Alan Boobis; Céline Brochot; Sandra Coecke; Andreas P Freidig; Ursula Gundert-Remy; Thomas Hartung; Miriam N Jacobs; Thierry Lavé; David Leahy; Hans Lennernäs; George D Loizou; Bette Meek; Camilla Pease; Malcolm Rowland; Martin Spendiff; Jiansong Yang; Marco Zeilmaker
Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63.
Alternatives to laboratory animals : ATLA 2007;35(6):661-71.
2007: Susanne Deininger; Ignacio Figueroa-Perez; Stefanie Sigel; Andreas Stadelmaier; Richard R Schmidt; Thomas Hartung; Sonja Von Aulock
Use of synthetic derivatives to determine the minimal active structure of cytokine-inducing lipoteichoic acid.
Clinical and vaccine immunology : CVI 2007;14(12):1629-33.
2007: Céline Borlon; Patrice Godard; Chantra Eskes; Thomas Hartung; Valérie Zuang; Olivier Toussaint
The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis.
Toxicology 2007;241(3):157-66.
2007: Erwin van Vliet; Luc Stoppini; Maurizio Balestrino; Chantra Eskes; Claudius Griesinger; Tomasz Sobanski; Maurice Whelan; Thomas Hartung; Sandra Coecke
Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects.
Neurotoxicology 2007;28(6):1136-46.
2007: Jens P Linge; Thomas Hartung
ECVAM's approach to intellectual property rights in the validation of alternative methods.
Alternatives to laboratory animals : ATLA 2007;35(4):441-6.
2007: Nicolas Larmonier; Dominique Cathelin; Claire B Larmonier; Alexandra Nicolas; Delphine Merino; Nona Janikashvili; Sylvain Audia; Andrew Bateman; Jill Thompson; Timothy Kottke; Thomas Hartung; Emmanuel Katsanis; Richard Vile; Bernard Bonnotte
The inhibition of TNF-alpha anti-tumoral properties by blocking antibodies promotes tumor growth in a rat model.
Experimental cell research 2007;313(11):2345-55.
2007: Sandra Coecke; Alan M Goldberg; Sandra Allen; Leonora Buzanska; Gemma Calamandrei; Kevin Crofton; Lars Hareng; Thomas Hartung; Holger Knaut; Paul Honegger; Miriam Jacobs; Pamela J Lein; Abby Li; William Mundy; David Owen; Steffen Schneider; Ellen K Silbergeld; Torsten Reum; Tomás Trnovec; Florianne Monnet-Tschudi; Anna Bal-Price
Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies.
Environmental health perspectives 2007;115(6):924-31.
2007: Liisa Räisänen; Christian Draing; Markus Pfitzenmaier; Karin Schubert; Tiina Jaakonsaari; Sonja Von Aulock; Thomas Hartung; Tapani Alatossava
Molecular interaction between lipoteichoic acids and Lactobacillus delbrueckii phages depends on D-alanyl and alpha-glucose substitution of poly(glycerophosphate) backbones.
Journal of bacteriology 2007;189(11):4135-40.
2007: Erwin van Vliet; Chantra Eskes; Silvia Stingele; Joanne Gartlon; Anna Price; Massimo Farina; Jessica Ponti; Thomas Hartung; Enrico Sabbioni; Sandra Coecke
Development of a mechanistically-based genetically engineered PC12 cell system to detect p53-mediated cytotoxicity.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(4):698-705.
2007: Stephan Spiller; Stefan Dreher; Guangxun Meng; Alina Grabiec; Winston Thomas; Thomas Hartung; Klaus Pfeffer; Hubertus Hochrein; Helmut Brade; Wolfgang Bessler; Hermann Wagner; Carsten J Kirschning
Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4.
The Journal of biological chemistry 2007;282(18):13190-8.
2007: Ian Kimber; Raymond Agius; David A Basketter; Emanuela Corsini; Paul Cullinan; Rebecca J Dearman; Elena Gimenez-Arnau; Leona Greenwell; Thomas Hartung; Frieke Kuper; Piero Maestrelli; Erwin Roggen; Costanza Rovida
Chemical respiratory allergy: opportunities for hazard identification and characterisation. The report and recommendations of ECVAM workshop 60.
Alternatives to laboratory animals : ATLA 2007;35(2):243-65.
2007: Artur Bauhofer; Ulrike Plaul; Alexander Torossian; Michael Koller; Benno Stinner; Ilhan Celik; Helmut Sitter; Bernd Greger; Martin Middeke; Moshe Schein; Jeremy Wyatt; Per-Olof Nyström; Thomas Hartung; Matthias Rothmund; Wilfried Lorenz
Perioperative prophylaxis with granulocyte colony-stimulating factor (G-CSF) in high-risk colorectal cancer patients for an improved recovery: A randomized, controlled trial.
Surgery 2007;141(4):501-10.
2007: David A Basketter; Camilla K Pease; Gerald Kasting; Ian Kimber; Silvia Casati; Mark Cronin; Walter Diembeck; Frank Gerberick; Jonathan Hadgraft; Thomas Hartung; Jean-Paul Marty; Efstathios Nikolaidis; Grace Patlewicz; David Roberts; Erwin Roggen; Costanza Rovida; Johannes J M van de Sandt
Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59.
Alternatives to laboratory animals : ATLA 2007;35(1):137-54.
2007: Hangeun Kim; Min Geun Gim; Joo Yun Kim; Hyun Jin Hwang; Min Seok Ham; Jung Min Lee; Thomas Hartung; Jung Woo Park; Seung Hyun Han; Dae Kyun Chung
Lipoteichoic acid from Lactobacillus plantarum elicits both the production of interleukin-23p19 and suppression of pathogen-mediated interleukin-10 in THP-1 cells.
FEMS immunology and medical microbiology 2007;49(2):205-14.
2007: Sonja Von Aulock; Thomas Hartung; Corinna Hermann
Comment on "Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus".
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2610; author reply 2610-1.
2007: Marina Hasiwa; Karin Kullmann; Sonja Von Aulock; Christoph Klein; Thomas Hartung
An in vitro pyrogen safety test for immune-stimulating components on surfaces.
Biomaterials 2007;28(7):1367-75.
2007: Mari Liljeroos; Reetta Vuolteenaho; S Morath; Thomas Hartung; Mikko Hallman; Marja Ojaniemi
Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages.
Cellular signalling 2007;19(3):625-33.
2007: Francesca Mazzotti; Julia Beuttler; Richard Zeller; Ulrich Fink; Stefanie Schindler; Albrecht Wendel; Thomas Hartung; Sonja Von Aulock
In vitro pyrogen test--A new test method for solid medical devices.
Journal of biomedical materials research. Part A 2007;80(2):276-82.
2007: M Carfi'; Alessandra Gennari; Ilaria Malerba; E Corsini; Marc Pallardy; R Pieters; H Van Loveren; H W Vohr; Thomas Hartung; Laura Gribaldo
In vitro tests to evaluate immunotoxicity: a preliminary study.
Toxicology 2007;229(1-2):11-22.
2007: Stefanie Schindler; Stefan Fennrich; Reto Crameri; Thomas W Jungi; Thomas Montag; Thomas Hartung
Fever in the test tube--towards a human(e) pyrogen test.
ALTEX 2007;24 Spec No():60-2.
2007: Annamaria A Bottini; Patric Amcoff; Thomas Hartung
Food for thought ... on globalisation of alternative methods.
ALTEX 2007;24(4):255-69.
2007: Susanne Bremer; Cristian Pellizzer; Sebastian Hoffmann; T Seidle; Thomas Hartung
The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes.
Current pharmaceutical design 2007;13(29):3047-58.
2007: Thomas Hartung
Food for thought... on cell culture.
ALTEX 2007;24(3):143-52.
2007: Thomas Hartung
Food for thought ... on validation.
ALTEX 2007;24(2):67-80.
2006: Ignacio Figueroa-Perez; Andreas Stadelmaier; Susanne Deininger; Sonja von Aulock; Thomas Hartung; Richard R Schmidt
Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction.
Carbohydrate research 2006;341(18):2901-11.
2006: Michael Balls; Patric Amcoff; Susanne Bremer; Silvia Casati; Sandra Coecke; Richard H Clothier; Robert Combes; Raffaella Corvi; rodger curren; Chantra Eskes; Julia Fentem; Laura Gribaldo; Marlies Halder; Thomas Hartung; Sebastian Hoffmann; Leonard Schectman; Laurie Scott; Horst Spielmann; William S Stokes; Raymond R Tice; Drew Wagner; Valérie Zuang
The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58.
Alternatives to laboratory animals : ATLA 2006;34(6):603-20.
2006: Christian Draing; Markus Pfitzenmaier; Sebastiana Zummo; Giuseppe Mancuso; Armin Geyer; Thomas Hartung; Sonja Von Aulock
Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae.
The Journal of biological chemistry 2006;281(45):33849-59.
2006: Stefanie Schindler; Ingo Spreitzer; Bettina Löschner; Sebastian Hoffmann; Kilian Hennes; Marlies Halder; Peter Brügger; Esther Frey; Thomas Hartung; Thomas Montag
International validation of pyrogen tests based on cryopreserved human primary blood cells.
Journal of immunological methods 2006;316(1-2):42-51.
2006: Mareike Mueller; Cordula Stamme; Christian Draing; Thomas Hartung; Ulrich Seydel; Andra B Schromm
Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein.
The Journal of biological chemistry 2006;281(42):31448-56.
2006: Martha Triantafilou; Frederick G J Gamper; Rowenna M Haston; Marios Angelos Mouratis; Siegfried Morath; Thomas Hartung; Kathy Triantafilou
Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.
The Journal of biological chemistry 2006;281(41):31002-11.
2006: Horst Spielmann; Andrea Seiler; Susanne Bremer; Lars Hareng; Thomas Hartung; Hans Ahr; Elaine Faustman; Ulla Haas; Graeme J Moffat; Heinz Nau; Philippe Vanparys; Aldert H Piersma; Juan Riego Sintes; Jane Stuart
The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57).
Alternatives to laboratory animals : ATLA 2006;34(5):527-38.
2006: Markus Mueller; Sebastian Bunk; Isabel Diterich; Michael Weichel; Carolin Rauter; Dieter Hassler; Corinna Hermann; Reto Crameri; Thomas Hartung
Identification of Borrelia burgdorferi ribosomal protein L25 by the phage surface display method and evaluation of the protein's value for serodiagnosis.
Journal of clinical microbiology 2006;44(10):3778-80.
2006: Agnieszka Kinsner; Monica Boveri; Lars Hareng; Guy C Brown; Sandra Coecke; Thomas Hartung; Anna Bal-Price
Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide.
Journal of neurochemistry 2006;99(2):596-607.
2006: Andreas Stadelmaier; Ignacio Figueroa-Perez; Susanne Deininger; Sonja Von Aulock; Thomas Hartung; Richard R Schmidt
A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues.
Bioorganic & medicinal chemistry 2006;14(18):6239-54.
2006: S Hoffmann; Thomas Hartung
Toward an evidence-based toxicology.
Human & experimental toxicology 2006;25(9):497-513.
2006: Stefanie Schindler; U Rosenberg; D Schlote; K Panse; A Kempe; Stefan Fennrich; Thomas Hartung
Pyrogen testing of lipidic parenterals with a novel in vitro test--application of the IPT based on cryopreserved human whole blood.
Pharmeuropa scientific notes 2006;2006(1):1-7.
2006: Rubén Alvarez-Sanchez; François Montavon; Thomas Hartung; Axel Pähler
Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
Chemical research in toxicology 2006;19(8):1106-16.
2006: Olaf Scheel; Martin Papavlassopoulos; Rikard Blunck; Andreas Gebert; Thomas Hartung; Ulrich Zähringer; Ulrich Seydel; Andra B Schromm
Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages.
Infection and immunity 2006;74(7):4354-6.
2006: Mardas Daneshian; Armin Guenther; Albrecht Wendel; Thomas Hartung; Sonja Von Aulock
In vitro pyrogen test for toxic or immunomodulatory drugs.
Journal of immunological methods 2006;313(1-2):169-75.
2006: Pilar Prieto; Alan W Baird; Bas J Blaauboer; Jose Vicente Castell Ripoll; Raffaella Corvi; Wolfgang Dekant; Paul Dietl; Alessandra Gennari; Laura Gribaldo; Julian L Griffin; Thomas Hartung; Jerry J Heindel; Peter Hoet; Paul Jennings; Luciana Marocchio; Jens Noraberg; Patricia Pazos; Carl Westmoreland; Armin Wolf; Jayne Wright; Walter Pfaller
The assessment of repeated dose toxicity in vitro: a proposed approach. The report and recommendations of ECVAM workshop 56.
Alternatives to laboratory animals : ATLA 2006;34(3):315-41.
2006: Sebastian Hoffmann; Thomas Hartung
Designing validation studies more efficiently according to the modular approach: retrospective analysis of the EPISKIN test for skin corrosion.
Alternatives to laboratory animals : ATLA 2006;34(2):177-91.
2006: Emmanuelle Palumbo; Marie Deghorain; Pier Sandro Cocconcelli; Michiel Kleerebezem; Armin Geyer; Thomas Hartung; Siegfried Morath; Pascal Hols
D-alanyl ester depletion of teichoic acids in Lactobacillus plantarum results in a major modification of lipoteichoic acid composition and cell wall perforations at the septum mediated by the Acm2 autolysin.
Journal of bacteriology 2006;188(10):3709-15.
2006: Sarah Adler; Cristian Pellizzer; Martin Paparella; Thomas Hartung; Susanne Bremer
The effects of solvents on embryonic stem cell differentiation.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(3):265-71.
2006: Katja Hattar; Ulrich Grandel; Alexander Moeller; Ludger Fink; Julia Iglhaut; Thomas Hartung; Siegfried Morath; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-[alpha] in mediating LTA-induced interleukin-8 generation.
Critical care medicine 2006;34(3):835-41.
2006: Raffaella Corvi; Hans-Jürgen Ahr; Silvio Albertini; David Blakey; Libero Clerici; Sandra Coecke; George R Douglas; Laura Gribaldo; John P Groten; Bernd Haase; Karen Hamernik; Thomas Hartung; Tohru Inoue; Ian Indans; Daniela Maurici; George Orphanides; Diana Rembges; Susanna-Assunta Sansone; Jason R Snape; Eisaku Toda; Weida Tong; Joost H M van Delft; Brenda Weis; Leonard M Schechtman
Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.
Environmental health perspectives 2006;114(3):420-9.
2006: Sandra Coecke; Chantra Eskes; Joanne Gartlon; Agnieszka Kinsner; Cristian Pellizzer; Anna Price; Pilar Prieto; Erwin van Vliet; Albrecht Wendel; Sarah Adler; Monica Boveri; Susanne Bremer; Thomas Hartung
The value of alternative testing for neurotoxicity in the context of regulatory needs.
Environmental toxicology and pharmacology 2006;21(2):153-67.
2006: Sandra Coecke; Hans Ahr; Bas J Blaauboer; Susanne Bremer; Silvia Casati; Josè Castell; Robert Combes; Raffaella Corvi; Charles L Crespi; Michael L Cunningham; Greetje Elaut; Brighitta Eletti; Andreas Freidig; Alessandra Gennari; Jean-François Ghersi-Egea; Andre Guillouzo; Thomas Hartung; Peter Hoet; Magnus Ingelman-Sundberg; Sharon Munn; Walter Janssens; Bernhard Ladstetter; David Leahy; Anthony Long; Annarita Meneguz; Mario Monshouwer; Siegfried Morath; Fred Nagelkerke; Olavi Pelkonen; Jessica Ponti; Pilar Prieto; Lysianne Richert; Enrico Sabbioni; Beatrice Schaack; Winfried Steiling; Emanuela Testai; Joan-Albert Vericat; Andrew Worth
Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.
Alternatives to laboratory animals : ATLA 2006;34(1):49-84.
2006: Corinna Hermann; Sonja Von Aulock; Oliver Dehus; Moritz Keller; Hiromi Okigami; Florian Gantner; Albrecht Wendel; Thomas Hartung
Endogenous cortisol determines the circadian rhythm of lipopolysaccharide-- but not lipoteichoic acid--inducible cytokine release.
European journal of immunology 2006;36(2):371-9.
2006: Sonja Lotz; Andrea Starke; Christian Ziemann; Siegfried Morath; Thomas Hartung; Werner Solbach; Tamás Laskay
Beta-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes.
Annals of clinical microbiology and antimicrobials 2006;5():15.
2006: Oliver Dehus; Thomas Hartung; Corinna Hermann
Endotoxin evaluation of eleven lipopolysaccharides by whole blood assay does not always correlate with Limulus amebocyte lysate assay.
Journal of endotoxin research 2006;12(3):171-80.
2006: Stephanie Traub; Sonja Von Aulock; Thomas Hartung; Corinna Hermann
MDP and other muropeptides--direct and synergistic effects on the immune system.
Journal of endotoxin research 2006;12(2):69-85.
2006: Alan M Goldberg; Thomas Hartung
Protecting more than animals.
Scientific American 2006;294(1):84-91.
2006: Monica Boveri; Agnieszka Kinsner; Vincent Berezowski; Anne-Marie Lenfant; C Draing; Roméo Cecchelli; Marie-Pierre Dehouck; Thomas Hartung; P Prieto; Anna Bal-Price
Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: role of pro-inflammatory cytokines and nitric oxide.
Neuroscience 2006;137(4):1193-209.
2005: Carolin Rauter; Thomas Hartung
Prevalence of Borrelia burgdorferi sensu lato genospecies in Ixodes ricinus ticks in Europe: a metaanalysis.
Applied and environmental microbiology 2005;71(11):7203-16.
2005: Agnieszka Kinsner; Valentina Pilotto; Susanne Deininger; Guy C Brown; Sandra Coecke; Thomas Hartung; Anna Bal-Price
Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation.
Journal of neurochemistry 2005;95(4):1132-43.
2005: Alexander H Dalpke; Martin D Lehner; Thomas Hartung; Klaus Heeg
Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance.
Immunology 2005;116(2):203-12.
2005: Christoph H Röhrig; Oliver A Retz; Lars Hareng; Thomas Hartung; Richard R Schmidt
A new strategy for the synthesis of dinucleotides loaded with glycosylated amino acids--investigations on in vitro non-natural amino acid mutagenesis for glycoprotein synthesis.
Chembiochem : a European journal of chemical biology 2005;6(10):1805-16.
2005: Katja Hattar; Sandra van Bürck; Annette Bickenbach; Ulrich Grandel; Ulrich A Maus; Jürgen Lohmeyer; Elena Csernok; Thomas Hartung; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation.
Journal of leukocyte biology 2005;78(4):992-1000.
2005: Lars Hareng; Cristian Pellizzer; Susanne Bremer; Michael Schwarz; Thomas Hartung
The integrated project ReProTect: a novel approach in reproductive toxicity hazard assessment.
Reproductive toxicology (Elmsford, N.Y.) 2005;20(3):441-52.
2005: Nicolas W J Schröder; Isabel Diterich; Antje Zinke; Jana Eckert; Christian Draing; Volker von Baehr; Dieter Hassler; Susanne Priem; Katrin Hahn; Kathrin S Michelsen; Thomas Hartung; Gerd R Burmester; Ulf B Göbel; Corinna Hermann; Ralf R Schumann
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2534-40.
2005: Monica Boveri; Vincent Berezowski; Anna Price; Stephanie Slupek; Anne-Marie Lenfant; Christelle Benaud; Thomas Hartung; Roméo Cecchelli; Pilar Prieto; Marie-Pierre Dehouck
Induction of blood-brain barrier properties in cultured brain capillary endothelial cells: comparison between primary glial cells and C6 cell line.
Glia 2005;51(3):187-98.
2005: Ulrich Grandel; Michael Hopf; Michael Buerke; Katja Hattar; Martina Heep; Ludger Fink; Rainer M Bohle; Siegfried Morath; Thomas Hartung; Soni Pullamsetti; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts.
Circulation 2005;112(5):691-8.
2005: Carolin Rauter; Markus Mueller; Isabel Diterich; Sabine Zeller; Dieter Hassler; Thomas Meergans; Thomas Hartung
Critical evaluation of urine-based PCR assay for diagnosis of Lyme borreliosis.
Clinical and diagnostic laboratory immunology 2005;12(8):910-7.
2005: Alessia Bogni; Mario Monshouwer; Anna Moscone; Mats Hidestrand; Magnus Ingelman-Sundberg; Thomas Hartung; Sandra Coecke
Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles.
Toxicology in vitro : an international journal published in association with BIBRA 2005;19(5):621-9.
2005: Corinne Grangette; Sophie Nutten; Emmanuelle Palumbo; Siegfried Morath; Corinna Hermann; Joelle Dewulf; Bruno Pot; Thomas Hartung; Pascal Hols; Annick Mercenier
Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10321-6.
2005: Sandra Coecke; Michael Balls; Gerard Bowe; John Davis; Gerhard Gstraunthaler; Thomas Hartung; Robert Hay; Otto-Wilhelm Merten; Anna Price; Leonard M Schechtman; Glyn Stacey; William S Stokes
Guidance on good cell culture practice. a report of the second ECVAM task force on good cell culture practice.
Alternatives to laboratory animals : ATLA 2005;33(3):261-87.
2005: Philipp Henneke; Siegfried Morath; Satoshi Uematsu; Stefan Weichert; Markus Pfitzenmaier; Osamu Takeuchi; Andrea Müller; Claire Poyart; Shizuo Akira; Reinhard Berner; Giuseppe Teti; Armin Geyer; Thomas Hartung; Patrick Trieu-Cuot; Dennis L Kasper; Douglas T Golenbock
Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6449-55.
2005: Sebastian Hoffmann; Thomas Hartung
Diagnosis: toxic!--trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):422-8.
2005: Alessandra Gennari; Masarin Ban; Armin Braun; Silvia Casati; Emanuela Corsini; Jaroslaw Dastych; Jacques Descotes; Thomas Hartung; Robert Hooghe-Peters; Robert House; Marc Pallardy; Raymond Pieters; Lynnda Reid; Helen Tryphonas; Eric Tschirhart; Helga Tuschl; Rob Vandebriel; Laura Gribaldo
The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop.
Journal of immunotoxicology 2005;2(2):61-83.
2005: Sarah Adler; Martin Paparella; Cristian Pellizzer; Thomas Hartung; Susanne Bremer
The detection of differentiation-inducing chemicals by using green fluorescent protein expression in genetically engineered teratocarcinoma cells.
Alternatives to laboratory animals : ATLA 2005;33(2):91-103.
2005: Sebastian Hoffmann; Thomas Cole; Thomas Hartung
Skin irritation: prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals.
Regulatory toxicology and pharmacology : RTP 2005;41(3):159-66.
2005: Sebastian Hoffmann; Anja Peterbauer; Stefanie Schindler; Stefan Fennrich; Stephen Poole; Yogesh Mistry; Thomas Montag-Lessing; Ingo Spreitzer; Bettina Löschner; Mirjam van Aalderen; Rogier Bos; Martin Gommer; Ria Nibbeling; Gabriele Werner-Felmayer; Petra Loitzl; Thomas W Jungi; Marija Brcic; Peter Brügger; Esther Frey; Gerard Bowe; Juan Casado; Sandra Coecke; Jan de Lange; Bente Mogster; Lisbeth M Naess; Ingeborg S Aaberge; Albrecht Wendel; Thomas Hartung
International validation of novel pyrogen tests based on human monocytoid cells.
Journal of immunological methods 2005;298(1-2):161-73.
2005: Ilona Kindinger; Mardas Daneshian; Hans Baur; Thomas Gabrio; Andreas Hofmann; Stefan Fennrich; Sonja Von Aulock; Thomas Hartung
A new method to measure air-borne pyrogens based on human whole blood cytokine response.
Journal of immunological methods 2005;298(1-2):143-53.
2005: Søren Lund; Peter Porzgen; Anne Louise Mortensen; Henrik Hasseldam; Donna Bozyczko-Coyne; Siegfried Morath; Thomas Hartung; Marina Bianchi; Pietro Ghezzi; Malika Bsibsi; Sipke Dijkstra; Marcel Leist
Inhibition of microglial inflammation by the MLK inhibitor CEP-1347.
Journal of neurochemistry 2005;92(6):1439-51.
2005: Kasper Hoebe; Philippe Georgel; Sophie Rutschmann; Xin Du; Suzanne Mudd; Karine Crozat; Sosathya Sovath; Louis Shamel; Thomas Hartung; Ulrich Zähringer; Bruce Beutler
CD36 is a sensor of diacylglycerides.
Nature 2005;433(7025):523-7.
2005: Silvia Casati; Pierre Aeby; David A Basketter; Andrea Cavani; Alessandra Gennari; G Frank Gerberick; Peter Griem; Thomas Hartung; Ian Kimber; Jean-Pierre Lepoittevin; B Jean Meade; Marc Pallardy; Nathalie Rougier; Francoise Rousset; Gilles Rubinstenn; Federica Sallusto; Geert R Verheyen; Valérie Zuang
Dendritic cells as a tool for the predictive identification of skin sensitisation hazard.
Alternatives to laboratory animals : ATLA 2005;33(1):47-62.
2005: Siegfried Morath; Sonja Von Aulock; Thomas Hartung
Structure/function relationships of lipoteichoic acids.
Journal of endotoxin research 2005;11(6):348-56.
2005: Cristian Pellizzer; Susanne Bremer; Thomas Hartung
Developmental toxicity testing from animal towards embryonic stem cells.
ALTEX 2005;22(2):47-57.
2005: Sebastian Hoffmann; Ursula Luderitz-Puchel; Thomas Montag; Thomas Hartung
Optimisation of pyrogen testing in parenterals according to different pharmacopoeias by probabilistic modelling.
Journal of endotoxin research 2005;11(1):25-31.
2004: Thomas Hartung; Laura Gribaldo
New hepatocytes for toxicology?
Trends in biotechnology 2004;22(12):613-5; discussion 615-6.
2004: Dana Zeidler; Ulrich Zähringer; Isak Gerber; Ian Dubery; Thomas Hartung; Wolf Bors; Peter Hutzler; Jörg Durner
Innate immunity in Arabidopsis thaliana: lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15811-6.
2004: Thomas Hartung; Susanne Bremer; Silvia Casati; Sandra Coecke; Raffaella Corvi; Salvador Fortaner; Laura Gribaldo; Marlies Halder; Sebastian Hoffmann; Annett Janusch Roi; Pilar Prieto; Enrico Sabbioni; Laurie Scott; Andrew P Worth; Valérie Zuang
A modular approach to the ECVAM principles on test validity.
Alternatives to laboratory animals : ATLA 2004;32(5):467-72.
2004: Stefanie Schindler; Silvia Asmus; Sonja Von Aulock; Albrecht Wendel; Thomas Hartung; Stefan Fennrich
Cryopreservation of human whole blood for pyrogenicity testing.
Journal of immunological methods 2004;294(1-2):89-100.
2004: Sonja Von Aulock; Isabel Diterich; Lars Hareng; Thomas Hartung
G-CSF: boosting endogenous production--a new strategy?
Current opinion in investigational drugs (London, England : 2000) 2004;5(11):1148-52.
2004: Andrew P Worth; Thomas Hartung; C J Van Leeuwen
The role of the European centre for the validation of alternative methods (ECVAM) in the validation of (Q)SARs.
SAR and QSAR in environmental research 2004;15(5-6):345-58.
2004: Andrew P Worth; C J Van Leeuwen; Thomas Hartung
The prospects for using (Q)SARs in a changing political environment--high expectations and a key role for the European Commission's joint research centre.
SAR and QSAR in environmental research 2004;15(5-6):331-43.
2004: Alessandra Gennari; Christine van den Berghe; Silvia Casati; José Castell; Cecilia Clemedson; Sandra Coecke; Alessandra Colombo; rodger curren; Gianni Dal Negro; Alan M Goldberg; Catherine Gosmore; Thomas Hartung; Ingrid Langezaal; Iglika Lessigiarska; Wilfred Maas; Inge Mangelsdorf; Ralph E Parchment; Pilar Prieto; Juan Riego Sintes; Michael Ryan; Gabriele Schmuck; Katherine Stitzel; William S Stokes; Joan-Albert Vericat; Laura Gribaldo
Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50.
Alternatives to laboratory animals : ATLA 2004;32(4):437-59.
2004: Cristian Pellizzer; Ezia Bello; Sarah Adler; Thomas Hartung; Susanne Bremer
Detection of tissue-specific effects by methotrexate on differentiating mouse embryonic stem cells.
Birth defects research. Part B, Developmental and reproductive toxicology 2004;71(5):331-41.
2004: Maria K Dahle; Gunhild Øverland; Anders E Myhre; Jon Fredrik Stuestøl; Thomas Hartung; Claus Danckert Krohn; Øystein Mathiesen; Jacob E Wang; Ansgar O Aasen
The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10.
Infection and immunity 2004;72(10):5704-11.
2004: Martha Triantafilou; Maria Manukyan; Alan Mackie; Siegfried Morath; Thomas Hartung; Holger Heine; Kathy Triantafilou
Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent.
The Journal of biological chemistry 2004;279(39):40882-9.
2004: Martha Triantafilou; Siegfried Morath; Alan Mackie; Thomas Hartung; Kathy Triantafilou
Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane.
Journal of cell science 2004;117(Pt 17):4007-14.
2004: Eva Mattsson; Thomas Hartung; Siegfried Morath; Arne Egesten
Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: comparison with peptidoglycan.
Infection and immunity 2004;72(7):4322-6.
2004: Corinna Hermann; Katja Gueinzius; Albrecht Oehme; Sonja Von Aulock; Eberhard Straube; Thomas Hartung
Comparison of quantitative and semiquantitative enzyme-linked immunosorbent assays for immunoglobulin G against Chlamydophila pneumoniae to a microimmunofluorescence test for use with patients with respiratory tract infections.
Journal of clinical microbiology 2004;42(6):2476-9.
2004: Cristian Pellizzer; Sarah Adler; Raffaella Corvi; Thomas Hartung; Susanne Bremer
Monitoring of teratogenic effects in vitro by analysing a selected gene expression pattern.
Toxicology in vitro : an international journal published in association with BIBRA 2004;18(3):325-35.
2004: Sylvia Knapp; Lars Hareng; Anita W Rijneveld; Paul Bresser; jaring s. van der zee; Sandrine Florquin; Thomas Hartung; Tom van der Poll
Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia.
The Journal of infectious diseases 2004;189(8):1506-15.
2004: Monica Boveri; Patricia Pazos; Alessandra Gennari; Juan Casado; Thomas Hartung; Pilar Prieto
Comparison of the sensitivity of different toxicological endpoints in Caco-2 cells after cadmium chloride treatment.
Archives of toxicology 2004;78(4):201-6.
2004: Mihai G Netea; Roger P M Sutmuller; Corinna Hermann; Chantal A A Van Der Graaf; Jos W M van der Meer; J H J M van Krieken; Thomas Hartung; Gosse J Adema; Bart Jan Kullberg
Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3712-8.
2004: Stephanie Traub; Niels Kubasch; Siegfried Morath; Matthias Kresse; Thomas Hartung; Richard R Schmidt; Corinna Hermann
Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction.
The Journal of biological chemistry 2004;279(10):8694-700.
2004: Sonja Von Aulock; Nicolas W J Schröder; Stephanie Traub; Katja Gueinzius; Eva Lorenz; Thomas Hartung; Ralf R Schumann; Corinna Hermann
Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses.
Infection and immunity 2004;72(3):1828-31.
2004: Sonja Lotz; Eresso Aga; Inga Wilde; Ger van Zandbergen; Thomas Hartung; Werner Solbach; Tamás Laskay
Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2.
Journal of leukocyte biology 2004;75(3):467-77.
2004: Sonja Von Aulock; Eva-Maria Boneberg; Isabel Diterich; Thomas Hartung
Granulocyte colony-stimulating factor (filgrastim) treatment primes for increased ex vivo inducible prostanoid release.
The Journal of pharmacology and experimental therapeutics 2004;308(2):754-9.
2004: Nicholas J Lynch; Silke Roscher; Thomas Hartung; Siegfried Morath; Misao Matsushita; Daniela N Maennel; Mikio Kuraya; Teizo Fujita; Wilhelm J Schwaeble
L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1198-202.
2004: Franz P Gruber; Thomas Hartung
Alternatives to animal experimentation in basic research.
ALTEX 2004;21 Suppl 1():3-31.
2004: S Bremer; Thomas Hartung
The use of embryonic stem cells for regulatory developmental toxicity testing in vitro--the current status of test development.
Current pharmaceutical design 2004;10(22):2733-47.
2004: Paul Jennings; Christian Koppelstaetter; Walter Pfaller; Jean-Paul Morin; Thomas Hartung; Michael P Ryan
Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 2: toxicological evaluation.
ALTEX 2004;21(2):61-6.
2004: Christian Koppelstaetter; Paul Jennings; Michael P Ryan; Jean-Paul Morin; Thomas Hartung; Walter Pfaller
Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 1: technical description.
ALTEX 2004;21(2):51-60.
2004: Christian Schneider; Sonja Von Aulock; Siegfried Zedler; Christian Schinkel; Thomas Hartung; Eugen Faist
Perioperative recombinant human granulocyte colony-stimulating factor (Filgrastim) treatment prevents immunoinflammatory dysfunction associated with major surgery.
Annals of surgery 2004;239(1):75-81.
2003: Thomas Hartung; Susanne Bremer; Silvia Casati; Sandra Coecke; Raffaella Corvi; Salvador Fortaner; Laura Gribaldo; Marlies Halder; Annett Janusch Roi; Pilar Prieto; Enrico Sabbioni; Andrew P Worth; Valérie Zuang
ECVAM's response to the changing political environment for alternatives: consequences of the European Union chemicals and cosmetics policies.
Alternatives to laboratory animals : ATLA 2003;31(5):473-81.
2003: Soeren Westerholt; Anne-Kathrin Pieper; Martin Griebel; Hans-Dieter Volk; Thomas Hartung; Renate Oberhoffer
Characterization of the cytokine immune response in children who have experienced an episode of typical hemolytic-uremic syndrome.
Clinical and diagnostic laboratory immunology 2003;10(6):1090-5.
2003: Nina C Weber; Signe B Blumenthal; Thomas Hartung; Angelika M Vollmar; Alexandra K Kiemer
ANP inhibits TNF-alpha-induced endothelial MCP-1 expression--involvement of p38 MAPK and MKP-1.
Journal of leukocyte biology 2003;74(5):932-41.
2003: Sonja Von Aulock; Nicolas W J Schröder; Katja Gueinzius; Stephanie Traub; Sebastian Hoffmann; Kathrin Graf; Stefanie Dimmeler; Thomas Hartung; Ralf R Schumann; Corinna Hermann
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood.
The Journal of infectious diseases 2003;188(6):938-43.
2003: Lars Hareng; Thomas Meergans; Sonja Von Aulock; Hans-Dieter Volk; Thomas Hartung
Cyclic AMP increases endogenous granulocyte colony-stimulating factor formation in monocytes and THP-1 macrophages despite attenuated TNF-alpha formation.
European journal of immunology 2003;33(8):2287-96.
2003: Anita W Rijneveld; Sandrine Florquin; Thomas Hartung; Peter Speelman; Tom van der Poll
Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia.
The Journal of infectious diseases 2003;188(2):282-5.
2003: Eva-Maria Boneberg; Thomas Hartung
Febrile temperatures attenuate IL-1 beta release by inhibiting proteolytic processing of the proform and influence Th1/Th2 balance by favoring Th2 cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):664-8.
2003: Hans-Peter Keiss; Verena M Dirsch; Thomas Hartung; Thomas Haffner; Laurence Trueman; Jacques Auger; Rémi Kahane; Angelika M Vollmar
Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity.
The Journal of nutrition 2003;133(7):2171-5.
2003: Waheedullah Karzai; Xizhong Cui; Bjoern Mehlhorn; Eberhard Straube; Thomas Hartung; Eric Gerstenberger; Steven M Banks; Charles Natanson; Konrad Reinhart; Peter Q Eichacker
Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats.
Anesthesiology 2003;99(1):81-9.
2003: Isabel Diterich; Carolin Rauter; Carsten J Kirschning; Thomas Hartung
Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression.
Infection and immunity 2003;71(7):3979-87.
2003: Sonja Von Aulock; Corinna Hermann; Thomas Hartung
Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo.
Journal of immunological methods 2003;277(1-2):53-63.
2003: Nicolas W J Schröder; Corinna Hermann; Lutz Hamann; Ulf B Göbel; Thomas Hartung; Ralf R Schumann
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR.
Journal of molecular medicine (Berlin, Germany) 2003;81(6):368-72.
2003: Nicolas W J Schröder; Siegfried Morath; Christian Alexander; Lutz Hamann; Thomas Hartung; Ulrich Zähringer; Ulf B Göbel; Joerg R Weber; Ralf R Schumann
Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.
The Journal of biological chemistry 2003;278(18):15587-94.
2003: Susanne Deininger; Andreas Stadelmaier; Sonja Von Aulock; Siegfried Morath; Richard R Schmidt; Thomas Hartung
Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4134-8.
2003: Carolin Rauter; Thomas Hartung
[Infestation of ticks with Borrelia, and Lyme borreliosis in Germany].
MMW Fortschritte der Medizin 2003;145(15):36-8.
2003: Corinna Hermann; Sonja Von Aulock; Kathrin Graf; Thomas Hartung
A model of human whole blood lymphokine release for in vitro and ex vivo use.
Journal of immunological methods 2003;275(1-2):69-79.
2003: Alexandra K Kiemer; Thomas Hartung; Christian Huber; Angelika M Vollmar
Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway.
Journal of hepatology 2003;38(3):289-97.
2003: Andreas Stadelmaier; Siegfried Morath; Thomas Hartung; Richard R Schmidt
Synthesis of the first fully active lipoteichoic acid.
Angewandte Chemie (International ed. in English) 2003;42(8):916-20.
2003: Anita C E Vreugdenhil; Corine H Rousseau; Thomas Hartung; Jan Willem M Greve; Cornelis van 't Veer; Wim A Buurman
Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1399-405.
2003: Sonja Von Aulock; Siegfried Morath; Lars Hareng; Sylvia Knapp; Kok P M van Kessel; Jos van Strijp; Thomas Hartung
Lipoteichoic acid from Staphylococcus aureus is a potent stimulus for neutrophil recruitment.
Immunobiology 2003;208(4):413-22.
2003: Gunhild Øverland; Sigfried Morath; Arne Yndestad; Thomas Hartung; Christoph Thiemermann; Simon J Foster; Bård Smedsrød; Øystein Mathisen; Pål Aukrust; Ansgar O Aasen; Jacob E Wang
Lipoteichoic acid is a potent inducer of cytokine production in rat and human Kupffer cells in vitro.
Surgical infections 2003;4(2):181-91.
2003: Silvia Casati; Thomas Hartung
[EU: third report of the EU research animal numbers presented].
ALTEX 2003;20(2):93.
2003: Stefanie Schindler; Adrian Bristow; Tammy Cartmell; Thomas Hartung; Stefan Fennrich
Comparison of the reactivity of human and rabbit blood towards pyrogenic stimuli.
ALTEX 2003;20(2):59-63.
2003: Thomas Hartung; Sonja Von Aulock; Christian Schneider; Eugen Faist
How to leverage an endogenous immune defense mechanism: the example of granulocyte colony-stimulating factor.
Critical care medicine 2003;31(1 Suppl):S65-75.
2002: Thomas Hartung
Comparison and validation of novel pyrogen tests based on the human fever reaction.
Alternatives to laboratory animals : ATLA 2002;30 Suppl 2():49-51.
2002: Ingrid Langezaal; Sebastian Hoffmann; Thomas Hartung; Sandra Coecke
Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release.
Alternatives to laboratory animals : ATLA 2002;30(6):581-95.
2002: Lars Hareng; Thomas Hartung
Induction and regulation of endogenous granulocyte colony-stimulating factor formation.
Biological chemistry 2002;383(10):1501-17.
2002: Alexander H Dalpke; Markus Frey; Siegfried Morath; Thomas Hartung; Klaus Heeg
Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells.
Immunobiology 2002;206(4):392-407.
2002: Sebastian Hoffmann; Thomas Hartung; Jan Beran
Comments on the use of bootstrap resampling to assess the uncertainty of Cooper statistics.
Alternatives to laboratory animals : ATLA 2002;30(5):551-4; author reply 555-7.
2002: Eva Lorenz; Dhavalkumar D Patel; Thomas Hartung; David A Schwartz
Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide.
Infection and immunity 2002;70(9):4892-6.
2002: Thomas Hartung; Michael Balls; Claudia Bardouille; Olivier Blanck; Sandra Coecke; Gerhard Gstraunthaler; David Lewis
Good Cell Culture Practice. ECVAM Good Cell Culture Practice Task Force Report 1.
Alternatives to laboratory animals : ATLA 2002;30(4):407-14.
2002: Siegfried Morath; Andreas Stadelmaier; Armin Geyer; Richard R Schmidt; Thomas Hartung
Synthetic lipoteichoic acid from Staphylococcus aureus is a potent stimulus of cytokine release.
The Journal of experimental medicine 2002;195(12):1635-40.
2002: Randy Jacinto; Thomas Hartung; Charles E McCall; Liwu Li
Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6136-41.
2002: Eva-Maria Boneberg; Thomas Hartung
Granulocyte colony-stimulating factor attenuates LPS-stimulated IL-1beta release via suppressed processing of proIL-1beta, whereas TNF-alpha release is inhibited on the level of proTNF-alpha formation.
European journal of immunology 2002;32(6):1717-25.
2002: Espen Ellingsen; Siegfried Morath; Trude H Flo; Andra Schromm; Thomas Hartung; Christoph Thiemermann; Terje Espevik; Douglas T Golenbock; Daniel Foster; Rigmor Solberg; Ansgar O Aasen; Jacob Wang
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(5):BR149-56.
2002: Corinna Hermann; Kathrin Graf; Annemarie Groh; Eberhard Straube; Thomas Hartung
Comparison of eleven commercial tests for Chlamydia pneumoniae-specific immunoglobulin G in asymptomatic healthy individuals.
Journal of clinical microbiology 2002;40(5):1603-9.
2002: Martin D Lehner; Frank Schwoebel; Alexey Kotlyarov; Marcel Leist; Matthias Gaestel; Thomas Hartung
Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4667-73.
2002: Bryan G Yipp; Graciela Andonegui; Christopher J Howlett; Stephen M Robbins; Thomas Hartung; May Ho; Paul Kubes
Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4650-8.
2002: Eva-Maria Boneberg; Thomas Hartung
Molecular aspects of anti-inflammatory action of G-CSF.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(3):119-28.
2002: Alexandra K Kiemer; Martin D Lehner; Thomas Hartung; Angelika M Vollmar
Inhibition of cyclooxygenase-2 by natriuretic peptides.
Endocrinology 2002;143(3):846-52.
2002: Corinna Hermann; Ingo Spreitzer; Nicolas W J Schröder; Siegfried Morath; Martin D Lehner; Werner Fischer; Christine Schütt; Ralf R Schumann; Thomas Hartung
Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release.
European journal of immunology 2002;32(2):541-51.
2002: Siegfried Morath; Armin Geyer; Ingo Spreitzer; Corinna Hermann; Thomas Hartung
Structural decomposition and heterogeneity of commercial lipoteichoic Acid preparations.
Infection and immunity 2002;70(2):938-44.
2002: Stefanie Schindler; Thomas Hartung
Comparison and validation of novel pyrogen tests based on the human fever reaction.
Developments in biologicals 2002;111():181-6.
2002: Sonja Von Aulock; Thomas Hartung
Potential for immune reconstitution through G-CSF treatment of HIV patients.
Archivum immunologiae et therapiae experimentalis 2002;50(2):111-20.
2002: M D Lehner; Thomas Hartung
Endotoxin tolerance-mechanisms and beneficial effects in bacterial infection.
Reviews of physiology, biochemistry and pharmacology 2002;144():95-141.
2002: Hilmar Dörge; Rainer Schulz; Sergej Belosjorow; Heiner Post; Anita van de Sand; Ina Konietzka; Stilla Frede; Thomas Hartung; Jakob Vinten-Johansen; Keith A Youker; Mark L Entman; Raimund Erbel; Gerd Heusch
Coronary microembolization: the role of TNF-alpha in contractile dysfunction.
Journal of molecular and cellular cardiology 2002;34(1):51-62.
2002: Carolin Rauter; Rainer Oehme; Isabel Diterich; Matthias Engele; Thomas Hartung
Distribution of clinically relevant Borrelia genospecies in ticks assessed by a novel, single-run, real-time PCR.
Journal of clinical microbiology 2002;40(1):36-43.
2001: Alexandra Pfeiffer; Alfred Böttcher; Evelyn Orsó; M Kapinsky; Péter Nagy; Andrea Bodnár; Ingo Spreitzer; Gerhard Liebisch; Wolfgang Drobnik; K Gempel; M Horn; S Holmer; Thomas Hartung; G Multhoff; G Schütz; Hansgeorg Schindler; Artur J Ulmer; Holger Heine; Felix Stelter; Christine Schütt; Gregor Rothe; J Szöllôsi; Sándor Damjanovich; Gerd Schmitz
Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts.
European journal of immunology 2001;31(11):3153-64.
2001: J Koenraad van de Wetering; Martin van Eijk; Lambert M G van Golde; Thomas Hartung; Jos van Strijp; Joseph J Batenburg
Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria.
The Journal of infectious diseases 2001;184(9):1143-51.
2001: Claudia Sommer; Thies Lindenlaub; P Teuteberg; Maria Schäfers; Thomas Hartung; Klaus V Toyka
Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy.
Brain research 2001;913(1):86-9.
2001: Eva-Maria Boneberg; Thomas Hartung
Mistletoe lectin-1 increases tumor necrosis factor-alpha release in lipopolysaccharide-stimulated whole blood via inhibition of interleukin-10 production.
The Journal of pharmacology and experimental therapeutics 2001;298(3):996-1000.
2001: Sandra Coecke; Alessia Bogni; Ingrid Langezaal; Andrew P Worth; Thomas Hartung; Mario Monshouwer
The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(4-5):553-6.
2001: Ingrid Langezaal; Sandra Coecke; Thomas Hartung
Whole blood cytokine response as a measure of immunotoxicity.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(4-5):313-8.
2001: Kathrin S Michelsen; Alexandra Aicher; Mariette Mohaupt; Thomas Hartung; Stefanie Dimmeler; Carsten J Kirschning; Ralf R Schumann
The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2.
The Journal of biological chemistry 2001;276(28):25680-6.
2001: Thomas Hartung
Summary: EU standards measurements and testing project PL95-3407. Development of a standardised in vitro methodology for hepatic and renal toxicity testing.
Alternatives to laboratory animals : ATLA 2001;29(4):493-5.
2001: Walter Pfaller; Michael Balls; Richard H Clothier; Sandra Coecke; Paul J Dierickx; B Ekwall; B A Hanley; Thomas Hartung; Pilar Prieto; Michael P Ryan; G Schmuck; Dariusz Sladowski; Joan-Albert Vericat; Albrecht Wendel; A Wolf; J Zimmer
Novel advanced in vitro methods for long-term toxicity testing: the report and recommendations of ECVAM workshop 45. European Centre for the Validation of Alternative Methods.
Alternatives to laboratory animals : ATLA 2001;29(4):393-426.
2001: Andreas Weishaupt; Wolfgang Brück; Thomas Hartung; Klaus V Toyka; Ralf Gold
Schwann cell apoptosis in experimental autoimmune neuritis of the Lewis rat and the functional role of tumor necrosis factor-alpha.
Neuroscience letters 2001;306(1-2):77-80.
2001: B Opitz; Nicolas W J Schröder; Ingo Spreitzer; Kathrin S Michelsen; Carsten J Kirschning; Werner Hallatschek; Ulrich Zähringer; Thomas Hartung; Ulf B Göbel; Ralf R Schumann
Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation.
The Journal of biological chemistry 2001;276(25):22041-7.
2001: Martin D Lehner; Siegfried Morath; K S Michelsen; Ralf R Schumann; Thomas Hartung
Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5161-7.
2001: Carolin Feterowski; Heike Weighardt; Klaus Emmanuilidis; Thomas Hartung; Bernhard Holzmann
Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis.
European journal of immunology 2001;31(4):1268-77.
2001: Thomas Hartung; Ingeborg S Aaberge; S Berthold; G Carlin; E Charton; Sandra Coecke; Stefan Fennrich; M Fischer; M Gommer; Marlies Halder; K Haslov; M Jahnke; Thomas Montag-Lessing; Stephen Poole; Leonard M Schechtman; Albrecht Wendel; Gabriele Werner-Felmayer
Novel pyrogen tests based on the human fever reaction. The report and recommendations of ECVAM Workshop 43. European Centre for the Validation of Alternative Methods. European Centre for the Validation of Alternative Methods.
Alternatives to laboratory animals : ATLA 2001;29(2):99-123.
2001: Siegfried Morath; Armin Geyer; Thomas Hartung
Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus.
The Journal of experimental medicine 2001;193(3):393-7.
2001: Isabel Diterich; L Härter; Dieter Hassler; Albrecht Wendel; Thomas Hartung
Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients.
Infection and immunity 2001;69(2):687-94.
2001: Manfred Weiss; Guenther Fischer; Eberhard Barth; E Boneberg; E Marion Schneider; Michael Georgieff; Thomas Hartung
Dissociation of LPS-induced monocytic ex vivo production of granulocyte colony-stimulating factor (G-CSF) and TNF-alpha in patients with septic shock.
Cytokine 2001;13(1):51-54.
2001: Thomas Hartung
Three Rs potential in the development and quality control of pharmaceuticals.
ALTEX 2001;18 Suppl 1():3-13.
2001: Isabel Diterich; Thomas Hartung
Borrelia burgdorferi s.l., the infectious agent of Lyme borreliosis.
Contributions to microbiology 2001;8():72-89.
2001: Thomas Hartung; Gerhard Gstraunthaler; Sandra Coecke; D Lewis; O Blanck; Michael Balls
[Good cell culture practice (GCCP)--an initiative for standardization and quality control of in vitro studies. The establishment of an ECVAM Task Force on GCCP].
ALTEX 2001;18(1):75-8.
2001: M Fischer; B Keller-Stanislawski; S Schober-Bendixen; R Schosser; K Hacke; Thomas Hartung; Thomas Montag
[Effect of the preservative thiomersal on the release of interleukin-1 beta from human peripheral blood cells].
ALTEX 2001;18(1):47-9.
2001: M Schneider; Thomas Hartung
Induction of the chemokines IL-8 and MCP-1 in human whole blood by a cell-lysate of human fibroblast cells.
Immunology letters 2001;75(2):163-5.
2001: M D Lehner; J Ittner; Daniela S Bundschuh; Nico van Rooijen; Albrecht Wendel; Thomas Hartung
Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response.
Infection and immunity 2001;69(1):463-71.
2000: Andreas Weishaupt; Sebastian Jander; Wolfgang Brück; Tanja Kuhlmann; Martina Stienekemeier; Thomas Hartung; Klaus V Toyka; Guido Stoll; Ralf Gold
Molecular mechanisms of high-dose antigen therapy in experimental autoimmune encephalomyelitis: rapid induction of Th1-type cytokines and inducible nitric oxide synthase.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7157-63.
2000: Thomas Hartung; Sonja Von Aulock; M Freitag; Stefan Höxtermann; M Stücker; K Hoffmann; P Altmeyer; A Kottke; Albrecht Wendel
Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients.
Cytokine 2000;12(10):1570-4.
2000: Sonja Von Aulock; Eva-Maria Boneberg; Thomas Hartung
Intermittent G-CSF (filgrastim) treatment cannot induce lymphocytosis in volunteers.
Clinical pharmacology and therapeutics 2000;68(1):104.
2000: Alexandra K Kiemer; Thomas Hartung; Angelika M Vollmar
cGMP-mediated inhibition of TNF-alpha production by the atrial natriuretic peptide in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):175-81.
2000: Thies Lindenlaub; P Teuteberg; Thomas Hartung; Claudia Sommer
Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury.
Brain research 2000;866(1-2):15-22.
2000: S Westerholt; Thomas Hartung; M Tollens; A Güstrau; M Oberhoffer; H Karch; B Klare; K Pfeffer; Peter Emmrich; Renate Oberhoffer
Inflammatory and immunological parameters in children with haemolytic uremic syndrome (HUS) and gastroenteritis-pathophysiological and diagnostic clues.
Cytokine 2000;12(6):822-7.
2000: KM Al-Qaoud; E Pearlman; Thomas Hartung; J Klukowski; Bernhard Fleischer; Achim Hoerauf
A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5.
International immunology 2000;12(6):899-908.
2000: Andreas Weishaupt; Ralf Gold; Thomas Hartung; Stefanie Gaupp; A Wendel; Wolfgang Brück; Klaus V Toyka
Role of TNF-alpha in high-dose antigen therapy in experimental autoimmune neuritis: inhibition of TNF-alpha by neutralizing antibodies reduces T-cell apoptosis and prevents liver necrosis.
Journal of neuropathology and experimental neurology 2000;59(5):368-76.
2000: Thomas Hartung
[Hip, hip, hurrah! Americans celebrate Gen-Chip--are we celebrating too?].
ALTEX 2000;17(2):101-2.
2000: Eva-Maria Boneberg; Lars Hareng; Florian Gantner; Albrecht Wendel; Thomas Hartung
Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-gamma.
Blood 2000;95(1):270-6.
1999: Cordula Stamme; Daniela S Bundschuh; Thomas Hartung; U Gebert; Lutz Wollin; R Nüsing; Albrecht Wendel; Stefan Uhlig
Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice.
Infection and immunity 1999;67(11):5642-50.
1999: Thomas Hartung; W D Doecke; Daniela S Bundschuh; M A Foote; Florian Gantner; Corinna Hermann; A Lenz; S Milwee; B Rich; B Simon; Hans-Dieter Volk; Sonja Von Aulock; Albrecht Wendel
Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions.
Clinical pharmacology and therapeutics 1999;66(4):415-24.
1999: X Fan; Felix Stelter; R Menzel; R Jack; Ingo Spreitzer; Thomas Hartung; Christine Schütt
Structures in Bacillus subtilis are recognized by CD14 in a lipopolysaccharide binding protein-dependent reaction.
Infection and immunity 1999;67(6):2964-8.
1999: Wolfgang Ertel; Marius Johann Baptist Keel; U Buergi; Thomas Hartung; Hans-Georg Imhof; Otmar Trentz
Granulocyte colony-stimulating factor inhibits neutrophil apoptosis at the local site after severe head and thoracic injury.
The Journal of trauma 1999;46(5):784-92; discussion 792-3.
1999: M Oberhoffer; H Vogelsang; Stefan Russwurm; Thomas Hartung; Konrad Reinhart
Outcome prediction by traditional and new markers of inflammation in patients with sepsis.
Clinical chemistry and laboratory medicine : CCLM / FESCC 1999;37(3):363-8.
1999: Thomas Hartung
Granulocyte colony-stimulating factor: its potential role in infectious disease.
AIDS (London, England) 1999;13 Suppl 2():S3-9.
1999: Thomas Hartung
Anti-inflammatory aspects of Filgrastim and impact on IL-2 release.
Journal of hematotherapy & stem cell research 1999;8 Suppl 1():S21-2.
1999: Stefan Fennrich; M Fischer; Thomas Hartung; P Lexa; Thomas Montag-Lessing; H G Sonntag; M Weigandt; Albrecht Wendel
Detection of endotoxins and other pyrogens using human whole blood.
Developments in biological standardization 1999;101():131-9.
1999: Thomas Hartung
Immunomodulation by colony-stimulating factors.
Reviews of physiology, biochemistry and pharmacology 1999;136():1-164.
1998: Thomas Hartung; Sonja Von Aulock; Albrecht Wendel
Role of granulocyte colony-stimulating factor in infection and inflammation.
Medical microbiology and immunology 1998;187(2):61-9.
1998: Thomas Hartung; D L Pitrak; M Foote; E M Shatzen; S C Verral; Albrecht Wendel
Filgrastim restores interleukin-2 production in blood from patients with advanced human immunodeficiency virus infection.
The Journal of infectious diseases 1998;178(3):686-92.
1998: Giorgio Senaldi; Christine L Shaklee; B Simon; C G Rowan; D L Lacey; Thomas Hartung
Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro.
Hepatology (Baltimore, Md.) 1998;27(6):1584-91.
1998: Thomas Hartung
Anti-inflammatory effects of granulocyte colony-stimulating factor.
Current opinion in hematology 1998;5(3):221-5.
1998: Felix Stelter; Sabine Witt; Birgitt Fürll; Robert S Jack; Thomas Hartung; Christine Schütt
Different efficacy of soluble CD14 treatment in high- and low-dose LPS models.
European journal of clinical investigation 1998;28(3):205-13.
1997: Brigitte Vollmar; S Messner; G A Wanner; Thomas Hartung; Michael D Menger
Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: an intravital microscopic analysis of Kupffer cell and leukocyte response.
Journal of leukocyte biology 1997;62(6):710-8.
1997: Marius Johann Baptist Keel; U Ungethüm; Ursula Steckholzer; E Niederer; Thomas Hartung; Otmar Trentz; Wolfgang Ertel
Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis.
Blood 1997;90(9):3356-63.
1997: F Randow; W D Döcke; Daniela S Bundschuh; Thomas Hartung; Albrecht Wendel; Hans-Dieter Volk
In vitro prevention and reversal of lipopolysaccharide desensitization by IFN-gamma, IL-12, and granulocyte-macrophage colony-stimulating factor.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2911-8.
1997: Daniela S Bundschuh; Johannes Barsig; Thomas Hartung; F Randow; W D Döcke; Hans-Dieter Volk; Albrecht Wendel
Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2862-71.
1997: Thomas Hartung; A Sauer; C Hermann; F Brockhaus; Albrecht Wendel
Overactivation of the immune system by translocated bacteria and bacterial products.
Scandinavian journal of gastroenterology. Supplement 1997;222():98-9.
1996: A Sauer; Thomas Hartung; J Aigner; Albrecht Wendel
Endotoxin-inducible granulocyte-mediated hepatocytotoxicity requires adhesion and serine protease release.
Journal of leukocyte biology 1996;60(5):633-43.
1996: J Barsig; Daniela S Bundschuh; Thomas Hartung; A Bauhofer; A Sauer; Albrecht Wendel
Control of fecal peritoneal infection in mice by colony-stimulating factors.
The Journal of infectious diseases 1996;174(4):790-9.
1996: Thomas Hartung; A Sauer; Albrecht Wendel
Testing of immunomodulatory properties in vitro.
Developments in biological standardization 1996;86():85-96.
1995: Thomas Hartung; Wolf-Dietrich Döcke; Florian Gantner; G Krieger; A Sauer; P Stevens; Hans-Dieter Volk; Albrecht Wendel
Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers.
Blood 1995;85(9):2482-9.
1992: I Görgen; Thomas Hartung; Marcel Leist; M Niehörster; Gisa Tiegs; Stefan Uhlig; F Weitzel; Albrecht Wendel
Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):918-24.
1992: Thomas Hartung; Albrecht Wendel
Endotoxin-inducible cytotoxicity in liver cell cultures--II. Demonstration of endotoxin-tolerance.
Biochemical pharmacology 1992;43(2):191-6.
1992: Thomas Hartung; Gisa Tiegs; Albrecht Wendel
The role of leukotriene D4 in septic shock models.
Eicosanoids 1992;5 Suppl():S42-4.
1991: Thomas Hartung; Albrecht Wendel
Endotoxin-inducible cytotoxicity in liver cell cultures--I.
Biochemical pharmacology 1991;42(5):1129-35.