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Yiping He

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Genglin Jin; Giselle Y Lopez; Roger E McLendon; B Ahmed Rasheed; Zachary J Reitman; Ivan Spasojevic; Darell D Bigner; Christopher G Duncan; David M Gooden; Yiping He; Rui Yang; Hai Yan
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Changcun Guo; Darell D Bigner; Chun-Chi Chang; Lee H Chen; Jen-Tsan Chi; Young-Wook Cho; Kai Ge; Gerald A Grant; Dawn N Kernagis; Roger E McLendon; Nickolas Papadopoulos; Xiaoxia Qin; Matthew Wortham; Hai Yan; Yiping He
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
Genglin Jin; Giselle Y Lopez; Christopher J Pirozzi; Ivan Spasojevic; Darell D Bigner; Lee H Chen; Christopher G Duncan; Jie Feng; Yiping He; Hai Yan
Mutant IDH1 is required for IDH1 mutated tumor cell growth.

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All Publications

2013: Genglin Jin; Giselle Y Lopez; Roger E McLendon; B Ahmed Rasheed; Zachary J Reitman; Ivan Spasojevic; Darell D Bigner; Christopher G Duncan; David M Gooden; Yiping He; Rui Yang; Hai Yan
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Cancer research 2013;73(2):496-501.
2012: Changcun Guo; Darell D Bigner; Chun-Chi Chang; Lee H Chen; Jen-Tsan Chi; Young-Wook Cho; Kai Ge; Gerald A Grant; Dawn N Kernagis; Roger E McLendon; Nickolas Papadopoulos; Xiaoxia Qin; Matthew Wortham; Hai Yan; Yiping He
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17603-8.
2012: Genglin Jin; Giselle Y Lopez; Christopher J Pirozzi; Ivan Spasojevic; Darell D Bigner; Lee H Chen; Christopher G Duncan; Jie Feng; Yiping He; Hai Yan
Mutant IDH1 is required for IDH1 mutated tumor cell growth.
Oncotarget 2012;3(8):774-82.
2012: Yuchen Jiao; Patrick J Killela; Kenneth W Kinzler; Eric Lipp; Giselle Lopez; Roger McLendon; Alan K Meeker; Sueli M Oba-Shinjo; Nickolas Papadopoulos; Christopher Pirozzi; Ahmed B Rasheed; Zachary J Reitman; Gregory J Riggins; Fausto J Rodriguez; Sergio Rosemberg; Bert Vogelstein; Nishant Agrawal; Chetan Bettegowda; Darell D Bigner; Peter C Burger; Roeland F de Wilde; Luis Alberto Diaz; Allan H Friedman; Henry Friedman; Yiping He; Christopher M Heaphy; Matthias Holdhoff; Suely Kazue Nagahashi Marie; Hai Yan
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
Oncotarget 2012;3(7):709-22.
2012: Matthew Wortham; Darell D Bigner; Yiping He; Genglin Jin; Julia Lailai Sun; Hai Yan
Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.
PloS one 2012;7(4):e36211.
2011: Christopher M Heaphy; Sachidanand Hebbar; Ralph Hruban; Yuchen Jiao; Kenneth W Kinzler; Alison P Klein; Anirban Maitra; Suely Kazue Nagahashi Marie; Roger McLendon; Sueli M Oba-Shinjo; G Johan A Offerhaus; Nickolas Papadopoulos; B Ahmed Rasheed; Gregory J Riggins; Fausto J Rodriguez; Chanjuan Shi; Bert Vogelstein; Hai Yan; Chetan Bettegowda; Darell D Bigner; Roeland F de Wilde; Charles G Eberhart; BARISH EDIL; Yiping He; Alan K Meeker
Altered telomeres in tumors with ATRX and DAXX mutations.
Science (New York, N.Y.) 2011;333(6041):425.
2011: Zachary J Reitman; Genglin Jin; Edward D Karoly; Ivan Spasojevic; Jian Yang; Kenneth W Kinzler; Yiping He; Darell D Bigner; Bert Vogelstein; Hai Yan
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3270-5.
2011: DONALD PARSONS; Meng Li; Xiaosong Zhang; Siân Jones; Rebecca J Leary; Jimmy Cheng-Ho Lin; Simina M Boca; Hannah Carter; Josue Samayoa; Chetan Bettegowda; Gary L Gallia; George I Jallo; Zev A Binder; Yuri Nikolsky; James Hartigan; Doug R Smith; Daniela S Gerhard; Daniel W Fults; Scott VandenBerg; Mitchel S Berger; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Carlos Clara; Peter C Phillips; Jane E Minturn; Jaclyn A Biegel; Alexander R Judkins; Adam C Resnick; Phillip B Storm; Tom Curran; Yiping He; B Ahmed Rasheed; Henry S Friedman; Stephen T Keir; Roger McLendon; Paul A Northcott; Michael D Taylor; Peter C Burger; Gregory J Riggins; Rachel Karchin; Giovanni Parmigiani; Darell D Bigner; Hai Yan; Nickolas Papadopoulos; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
The genetic landscape of the childhood cancer medulloblastoma.
Science (New York, N.Y.) 2011;331(6016):435-9.
2010: Yiping He; Jian Wu; Devin C Dressman; Christine A Iacobuzio-Donahue; Sanford D Markowitz; Victor E Velculescu; Luis Alberto Diaz; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.
Nature 2010;464(7288):610-4.
2009: Meng Li; Wei-Dong Chen; Nickolas Papadopoulos; Steven Goodman; Niels Christian Bjerregaard; Søren Laurberg; Bernard Levin; Hartmut Juhl; Nadir Arber; Helen Moinova; Kris Durkee; Kerstin Schmidt; Yiping He; Frank Diehl; Victor E Velculescu; Shibin Zhou; Luis Alberto Diaz; Kenneth W Kinzler; Sanford D Markowitz; Bert Vogelstein
Sensitive digital quantification of DNA methylation in clinical samples.
Nature biotechnology 2009;27(9):858-63.
2009: Yumi Yashiro-ohtani; Yiping He; Takuya Ohtani; Mary E Jones; Olga Shestova; Lanwei Xu; Terry C Fang; Mark Y Chiang; Andrew M Intlekofer; Stephen C Blacklow; Yuan Zhuang; Warren S Pear
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
Genes & development 2009;23(14):1665-76.
2008: Yiping He; Bert Vogelstein; Victor E Velculescu; Nickolas Papadopoulos; Kenneth W Kinzler
The antisense transcriptomes of human cells.
Science (New York, N.Y.) 2008;322(5909):1855-7.
2007: Alison M Michie; Angela Chan; Maria Ciofani; Michael Carleton; Juliette M Lefebvre; Yiping He; David Allman; David L. Wiest; Juan Carlos Zúñiga-Pflücker; David J Izon
Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.
International immunology 2007;19(12):1421-30.
2007: Bas J Wouters; Meritxell Alberich Jordà; Karen Keeshan; Irene Louwers; Claudia A J Erpelinck-Verschueren; Dennis Tielemans; Anton Langerak; Yiping He; Yumi Yashiro-ohtani; Pu Zhang; Christopher J Hetherington; Roel G W Verhaak; Peter J M Valk; Bob Löwenberg; Daniel G Tenen; Warren S Pear; Ruud Delwel
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Blood 2007;110(10):3706-14.
2006: Karen Keeshan; Yiping He; Bas J Wouters; Olga Shestova; Lanwei Xu; Hong Sai; Carlos G Rodriguez; Ivan P Maillard; John W Tobias; Peter J M Valk; Martin Carroll; Jon C Aster; Ruud Delwel; Warren S Pear
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.
Cancer cell 2006;10(5):401-11.
2006: Frank Diehl; Meng Li; Yiping He; Kenneth W Kinzler; Bert Vogelstein; Devin Dressman
BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions.
Nature methods 2006;3(7):551-9.
2006: Jordan M Cummins; Yiping He; Rebecca J Leary; Ray Pagliarini; Luis Alberto Diaz; Tobias Sjoblom; Omer Barad; Zvi Bentwich; Anna E Szafranska; Emmanuel Labourier; Christopher K Raymond; Brian S Roberts; Hartmut Juhl; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
The colorectal microRNAome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3687-92.
2005: Patrick A Zweidler-McKay; Yiping He; Lanwei Xu; Carlos G Rodriguez; Fredrick G Karnell; Andrea C Carpenter; Jon C Aster; David Allman; Warren S Pear
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
Blood 2005;106(12):3898-906.
2005: Frank Diehl; Meng Li; Devin Dressman; Yiping He; Dong Shen; Stephen Szabo; Luis Alberto Diaz; Steven Goodman; Kerstin A David; Hartmut Juhl; Kenneth W Kinzler; Bert Vogelstein
Detection and quantification of mutations in the plasma of patients with colorectal tumors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16368-73.
2004: Todd N Eagar; Qizhi Tang; Michael S Wolfe; Yiping He; Warren S Pear; Jeffrey A Bluestone
Notch 1 signaling regulates peripheral T cell activation.
Immunity 2004;20(4):407-15.
2003: Ivan P Maillard; Yiping He; Warren S Pear
From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis.
Immunity 2003;18(5):587-9.
2003: Yiping He; Warren S Pear
Notch signalling in B cells.
Seminars in cell & developmental biology 2003;14(2):135-42.
2002: Jason A Wertheim; Juli P Miller; Lanwei Xu; Yiping He; Warren S Pear
The biology of chronic myelogenous leukemia:mouse models and cell adhesion.
Oncogene 2002;21(56):8612-28.
2002: Yiping He; Jason A Wertheim; Lanwei Xu; Juli P Miller; Fredrick G Karnell; John K Choi; Ruibao Ren; Warren S Pear
The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.
Blood 2002;99(8):2957-68.
2002: David J Izon; Jon C Aster; Yiping He; Andrew P Weng; Fredrick G Karnell; Vytas Patriub; Lanwei Xu; Sonia Bakkour; Carlos Rodriguez; David Allman; Warren S Pear
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
Immunity 2002;16(2):231-43.