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Michael McDonough

Research Profile

Procedures

X Ray Crystallography

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Chemicals & Drugs

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Amino Acid Sequences

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Publications

TOP 3
Rasheduzzaman Chowdhury; Ian J Clifton; Emily Flashman; Yves-Michel Frapart; Benedikt M Kessler; Holger B Kramer; Michael McDonough; Jasmin Mecinović; Jean-Luc Boucher; Christopher J Schofield
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
Zhihong Zhang; Grazyna T Kochan; Stanley S Ng; Kathryn L Kavanagh; Udo Oppermann; Christopher J Schofield; Michael McDonough
Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.
Ming Yang; Rasheduzzaman Chowdhury; Wei Ge; Refaat B Hamed; Michael McDonough; Timothy D W Claridge; Benedikt M Kessler; Matthew E Cockman; Peter J Ratcliffe; Christopher J Schofield
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

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All Publications

2011: Rasheduzzaman Chowdhury; Ian J Clifton; Emily Flashman; Yves-Michel Frapart; Benedikt M Kessler; Holger B Kramer; Michael McDonough; Jasmin Mecinović; Jean-Luc Boucher; Christopher J Schofield
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
Journal of molecular biology 2011;410(2):268-79.
2011: Zhihong Zhang; Grazyna T Kochan; Stanley S Ng; Kathryn L Kavanagh; Udo Oppermann; Christopher J Schofield; Michael McDonough
Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.
Biochemical and biophysical research communications 2011;408(4):553-8.
2011: Ming Yang; Rasheduzzaman Chowdhury; Wei Ge; Refaat B Hamed; Michael McDonough; Timothy D W Claridge; Benedikt M Kessler; Matthew E Cockman; Peter J Ratcliffe; Christopher J Schofield
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
The FEBS journal 2011;278(7):1086-97.
2010: Ivanhoe K H Leung; Tobias J Krojer; Grazyna T Kochan; Luc Henry; Frank von Delft; Timothy D W Claridge; Udo Oppermann; Michael McDonough; Christopher J Schofield
Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
Chemistry & biology 2010;17(12):1316-24.
2010: Monica Mantri; Tobias Krojer; Eleanor A Bagg; Celia J Webby; Danica S Butler; Grazyna Kochan; Kathryn L Kavanagh; Udo Oppermann; Michael McDonough; Christopher J Schofield
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.
Journal of molecular biology 2010;401(2):211-22.
2010: Nathan R Rose; Esther C Y Woon; Guy L Kingham; Oliver N F King; Jasmin Mecinović; Ian J Clifton; Stanley S Ng; Jobina Talib-Hardy; Udo Oppermann; Michael McDonough; Christopher J Schofield
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
Journal of medicinal chemistry 2010;53(4):1810-8.
2010: Wyatt W Yue; Viktorija Hozjan; Wei Ge; Christoph Loenarz; Christopher D O Cooper; Christopher J Schofield; Kathryn L Kavanagh; Udo Oppermann; Michael McDonough
Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
FEBS letters 2010;584(4):825-30.
2009: Rasheduzzaman Chowdhury; Michael McDonough; Jasmin Mecinović; Christoph Loenarz; Emily Flashman; Kirsty S Hewitson; Carmen Domene; Christopher J Schofield
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
Structure (London, England : 1993) 2009;17(7):981-9.
2009: Leanne Kelly; Michael McDonough; Mathew L Coleman; Peter J Ratcliffe; Christopher J Schofield
Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold.
Molecular bioSystems 2009;5(1):52-8.
2008: Patrick J Pollard; Christoph Loenarz; David R Mole; Michael McDonough; Jonathan Gleadle; Christopher J Schofield; Peter J Ratcliffe
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
The Biochemical journal 2008;416(3):387-94.
2008: Nathan R Rose; Stanley S Ng; Jasmin Mecinović; Benoît M R Liénard; Simon H Bello; Zhe Sun; Michael McDonough; Udo Oppermann; Christopher J Schofield
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
Journal of medicinal chemistry 2008;51(22):7053-6.
2008: Kirsty S Hewitson; Samantha L Holmes; Dominic Ehrismann; Adam P Hardy; Rasheduzzaman Chowdhury; Christopher J Schofield; Michael McDonough
Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
The Journal of biological chemistry 2008;283(38):25971-8.
2008: Emily Flashman; Eleanor A L Bagg; Rasheduzzaman Chowdhury; Jasmin Mecinović; Christoph Loenarz; Michael McDonough; Kirsty S Hewitson; Christopher J Schofield
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
The Journal of biological chemistry 2008;283(7):3808-15.
2007: Thomas Gerken; Christophe A Girard; Yi-Chun Loraine Tung; Celia J Webby; Vladimir Saudek; Kirsty S Hewitson; Giles S H Yeo; Michael McDonough; Sharon Cunliffe; Luke A McNeill; Juris Galvanovskis; Patrik Rorsman; Peter Robins; Xavier Prieur; Anthony P Coll; Marcella Ma; Zorica Jovanovic; I Sadaf Farooqi; Barbara Sedgwick; Inês Barroso; Tomas Lindahl; Chris P Ponting; Frances M Ashcroft; Stephen O'Rahilly; Christopher J Schofield
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Science (New York, N.Y.) 2007;318(5855):1469-72.
2007: C J Schofield; Michael McDonough
Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).
Biochemical Society transactions 2007;35(Pt 5):870-5.
2007: Mathew L Coleman; Michael McDonough; Kirsty S Hewitson; Charlotte Coles; Jasmin Mecinovic; Mariola Edelmann; Kristina M Cook; Matthew E Cockman; David E Lancaster; Benedikt M Kessler; Neil J Oldham; Peter J Ratcliffe; Christopher J Schofield
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
The Journal of biological chemistry 2007;282(33):24027-38.
2007: Stanley S Ng; Kathryn L Kavanagh; Michael McDonough; Danica Butler; Ewa S Pilka; Benoit M R Lienard; James E Bray; Pavel Savitsky; Opher Gileadi; Frank von Delft; Nathan R Rose; John Offer; Johanna C Scheinost; Tomasz Borowski; Michael Sundstrom; Christopher J Schofield; Udo Oppermann
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature 2007;448(7149):87-91.
2007: Kirsty S Hewitson; Benoît M R Liénard; Michael McDonough; Ian J Clifton; Danica Butler; Alexie S Soares; Neil J Oldham; Luke A McNeill; Christopher J Schofield
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
The Journal of biological chemistry 2007;282(5):3293-301.
2006: Matthew E Cockman; David E Lancaster; Ineke P Stolze; Kirsty S Hewitson; Michael McDonough; Mathew L Coleman; Charlotte H Coles; Xiaohong Yu; Ron Thomas Hay; Steven C Ley; Christopher W Pugh; Neil J Oldham; Norma Masson; Christopher J Schofield; Peter J Ratcliffe
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14767-72.
2006: Michael McDonough; Vivian Li; Emily Flashman; Rasheduzzaman Chowdhury; Christopher Mohr; Benoît M R Liénard; James Zondlo; Neil J Oldham; Ian J Clifton; Jeffrey Lewis; Luke A McNeill; Robert Kurzeja; Kirsty S Hewitson; Evelyn Yang; Steven Jordan; Rashid S Syed; Christopher J Schofield
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9814-9.
2006: Ian J Clifton; Michael McDonough; Dominic Ehrismann; Nadia J Kershaw; Nicolas Granatino; Christopher J Schofield
Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.
Journal of inorganic biochemistry 2006;100(4):644-69.
2005: Michael McDonough; Kathryn L Kavanagh; Danica Butler; Timothy Searls; Udo Oppermann; Christopher J Schofield
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
The Journal of biological chemistry 2005;280(49):41101-10.
2005: Biswadip Banerji; Ana Conejo-Garcia; Luke A McNeill; Michael McDonough; Matthew R G Buck; Kirsty S Hewitson; Neil J Oldham; Christopher J Schofield
The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
Chemical communications (Cambridge, England) 2005;(43):5438-40.
2005: Mark C Sleeman; John L Sorensen; Edward T Batchelar; Michael McDonough; Christopher J Schofield
Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
The Journal of biological chemistry 2005;280(41):34956-65.
2005: Michael McDonough; Luke A McNeill; Melanie Tilliet; Cyril A Papamicaël; Qiu-Yun Chen; Biswadip Banerji; Kirsty S Hewitson; Christopher J Schofield
Selective inhibition of factor inhibiting hypoxia-inducible factor.
Journal of the American Chemical Society 2005;127(21):7680-1.
2005: Kirsty S Hewitson; N Granatino; Richard W D Welford; Michael McDonough; Christopher J Schofield
Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2005;363(1829):807-28; discussion 1035-40.
2005: Emily Flashman; Michael McDonough; Christopher J Schofield
OS-9: another piece in the HIF complex story.
Molecular cell 2005;17(4):472-3.
2004: David E Lancaster; Michael McDonough; Christopher J Schofield
Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
Biochemical Society transactions 2004;32(Pt 6):943-5.
2004: David E Lancaster; Luke A McNeill; Michael McDonough; Robin T Aplin; Kirsty S Hewitson; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
The Biochemical journal 2004;383(Pt. 3):429-37.
2004: Michael McDonough; Renuka Kadirvelraj; Pernille Harris; Jens-Christian Navarro Poulsen; Sine Larsen
Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4.
FEBS letters 2004;565(1-3):188-94.
2003: Michael McDonough; Christopher J Schofield
New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
Chemistry & biology 2003;10(10):898-900.
2002: Michael McDonough; John W Anderson; Nicholas R Silvaggi; Rex F Pratt; James R Knox; Judith A Kelly
Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
Journal of molecular biology 2002;322(1):111-22.
2002: Michael McDonough; Carsten Ryttersgaard; Mads Eskelund Bjørnvad; Leila Lo Leggio; Martin Schülein; Sanne O Schrøder Glad; Sine Larsen
Crystallization and preliminary X-ray characterization of a thermostable pectate lyase from Thermotoga maritima.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 4):709-11.
2001: W Lee; Michael McDonough; Lakshmi P Kotra; Z H Li; Nicholas R Silvaggi; Y Takeda; Judith A Kelly; Shahriar Mobashery
A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1427-31.
1999: Michael McDonough; H E Klei; J A Kelly
Crystal structure of penicillin G acylase from the Bro1 mutant strain of Providencia rettgeri.
Protein science : a publication of the Protein Society 1999;8(10):1971-81.