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Ann Mayne

Research Profile

Disorders

Simian Acquired Immunodeficiency Syndrome

Living Beings

Anatomy

Physiology

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Chemicals & Drugs

Procedures

Heart Transplantation

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Publications

TOP 3
Aftab A Ansari; Keith A Reimann; Ann Mayne; Yoshiaki Takahashi; Susan T Stephenson; Rijian Wang; Xinyue Wang; J Li; Andrew A Price; Dawn M Little; Mohammad Zaidi; Robert Lyles; Francios VILLINGER
Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques.
Nichole R Klatt; Francios VILLINGER; Pavel Bostik; Shari N Gordon; Lara Pereira; Jessica Engram; Ann Mayne; Richard Dunham; Benton Lawson; Sarah J Ratcliffe; Donald L Sodora; James ELSE; Keith Reimann; Silvija I Staprans; Ashley T Haase; Jacob D Estes; Guido Silvestri; Aftab A Ansari
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
Moiz Kitabwalla; Aftab A Ansari; Francios VILLINGER; Hassibullah Akeefe; Adam P Conner; Ann Mayne; James E K Hildreth
Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment.

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All Publications

2011: Aftab A Ansari; Keith A Reimann; Ann Mayne; Yoshiaki Takahashi; Susan T Stephenson; Rijian Wang; Xinyue Wang; J Li; Andrew A Price; Dawn M Little; Mohammad Zaidi; Robert Lyles; Francios VILLINGER
Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1044-59.
2008: Nichole R Klatt; Francios VILLINGER; Pavel Bostik; Shari N Gordon; Lara Pereira; Jessica Engram; Ann Mayne; Richard Dunham; Benton Lawson; Sarah J Ratcliffe; Donald L Sodora; James ELSE; Keith Reimann; Silvija I Staprans; Ashley T Haase; Jacob D Estes; Guido Silvestri; Aftab A Ansari
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
The Journal of clinical investigation 2008;118(6):2039-49.
2008: Moiz Kitabwalla; Aftab A Ansari; Francios VILLINGER; Hassibullah Akeefe; Adam P Conner; Ann Mayne; James E K Hildreth
Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment.
Experimental biology and medicine (Maywood, N.J.) 2008;233(6):732-40.
2008: Nattawat Onlamoon; Kenneth Rogers; Ann Mayne; Kovit Pattanapanyasat; Kazuyasu Mori; Francios VILLINGER; Aftab A Ansari
Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection.
Immunology 2008;124(2):277-93.
2007: Nattawat Onlamoon; Nicholas Plagman; Kenneth A Rogers; Ann Mayne; Pavel Bostik; Kovit Pattanapanyasat; Aftab A Ansari; Francios VILLINGER
Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer.
Journal of medical primatology 2007;36(4-5):206-18.
2007: Aftab A Ansari; Lara E Pereira; Ann Mayne; Nattawat Onlamoon; Kovit Pattanapanyasat; Kazuyasu Mori; Francios VILLINGER
The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates.
Journal of autoimmunity 2007;28(2-3):152-9.
2006: Nattawat Onlamoon; Krystal Hudson; Patsy Bryan; Ann Mayne; Mark Bonyhadi; Ronald J Berenson; Bruce J Sundstrom; Pavel Bostik; Aftab A Ansari; Francios VILLINGER
Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy.
Journal of medical primatology 2006;35(4-5):178-93.
2006: Pavel Bostik; Erika S Noble; Ann Mayne; Lisa Gargano; Francios VILLINGER; Aftab A Ansari
Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys.
AIDS (London, England) 2006;20(2):181-8.
2005: Moiz Kitabwalla; Francios VILLINGER; Hassibullah Akeefe; Zhaohao Liao; Ann Mayne; Lisa Gargano; Adam P Conner; Jo-Ann Maltais; Gretchen Kunas; James E K Hildreth; Aftab A Ansari; Marc Bellotti
Enhancement of cell mediated immune responses using lipid depleted lentivirus as immunogen: a novel approach for inducing recognition of new viral epitopes.
Vaccine 2005;23(38):4666-77.
2004: Francios VILLINGER; R Miller; Kazuyasu Mori; Ann Mayne; Pavel Bostik; J Bruce Sundstrom; C Sugimoto; Aftab A Ansari
IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques.
Vaccine 2004;22(25-26):3510-21.
2004: Pavel Bostik; Geraldine L Dodd; Francios VILLINGER; Ann Mayne; Aftab A Ansari
Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection.
Journal of virology 2004;78(3):1464-72.
2004: Aftab A Ansari; Ann Mayne; Nattawat Onlamoon; Kovit Pattanapanyasat; Kazuyasu Mori; Francios VILLINGER
Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS.
Immunologic research 2004;29(1-3):1-18.
2004: J Bruce Sundstrom; Hui Mao; Robert Santoianni; Francios VILLINGER; Dawn M Little; Toai T Huynh; Ann Mayne; Encai Hao; Aftab A Ansari
Magnetic resonance imaging of activated proliferating rhesus macaque T cells labeled with superparamagnetic monocrystalline iron oxide nanoparticles.
Journal of acquired immune deficiency syndromes (1999) 2004;35(1):9-21.
2003: Aftab A Ansari; Nattawat Onlamoon; Pavel Bostik; Ann Mayne; Lisa Gargano; Kovit Pattanapanyasat
Lessons learnt from studies of the immune characterization of naturally SIV infected sooty mangabeys.
Frontiers in bioscience : a journal and virtual library 2003;8():s1030-50.
2003: Francios VILLINGER; Ann Mayne; Pavel Bostik; Kazuyasu Mori; Peter E Jensen; Rafi Ahmed; Aftab A Ansari
Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques.
Journal of virology 2003;77(1):10-24.
2002: Aftab A Ansari; James D Fett; Robert E Carraway; Ann Mayne; Nattawat Onlamoon; J Bruce Sundstrom
Autoimmune mechanisms as the basis for human peripartum cardiomyopathy.
Clinical reviews in allergy & immunology 2002;23(3):301-24.
2002: Aftab A Ansari; Ann Mayne; J Bruce Sundstrom; Pavel Bostik; Bennett D Grimm; John D Altman; Francios VILLINGER
Administration of recombinant rhesus interleukin-12 during acute simian immunodeficiency virus (SIV) infection leads to decreased viral loads associated with prolonged survival in SIVmac251-infected rhesus macaques.
Journal of virology 2002;76(4):1731-43.
2002: Francios VILLINGER; Gary T Brice; Ann Mayne; Pavel Bostik; Kazuyasu Mori; Carl H June; Aftab A Ansari
Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status.
Blood 2002;99(2):590-9.
2002: Aftab A Ansari; Ann Mayne
Cytokine analysis by intracellular staining.
Methods in molecular medicine 2002;72():423-35.
2001: Pavel Bostik; P Wu; Geraldine L Dodd; Francios VILLINGER; Ann Mayne; Vanda Bostik; Bennett D Grimm; D Robinson; Hsing-Jien Kung; Aftab A Ansari
Identification of protein kinases dysregulated in CD4(+) T cells in pathogenic versus apathogenic simian immunodeficiency virus infection.
Journal of virology 2001;75(23):11298-306.
2001: Francios VILLINGER; Thomas Rowe; Bharat Parekh; Timothy A Green; Ann Mayne; Bennett D Grimm; Harold M McClure; Andrew Lackner; P J Dailey; Aftab A Ansari; Thomas M Folks
Chronic immune stimulation accelerates SIV-induced disease progression.
Journal of medical primatology 2001;30(5):254-9.
2001: Aftab A Ansari; Pavel Bostik; Ann Mayne; Francios VILLINGER
Failure to expand influenza and tetanus toxoid memory T cells in vitro correlates with disease course in SIV infected rhesus macaques.
Cellular immunology 2001;210(2):125-42.
2001: Francios VILLINGER; Pavel Bostik; Ann Mayne; C L King; C P Genain; W R Weiss; Aftab A Ansari
Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules.
Immunogenetics 2001;53(4):315-28.
2001: Pavel Bostik; Ann Mayne; Francios VILLINGER; K P Greenberg; Jonathan D Powell; Aftab A Ansari
Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):506-16.
2000: Francios VILLINGER; William Switzer; Bharat Parekh; Ron A Otten; D Adams; Vedapuri Shanmugam; Pavel Bostik; Ann Mayne; NF Chikkala; Harold M McClure; Francis J Novembre; Qizhi Yao; Walid Heneine; Thomas M Folks; Aftab A Ansari
Induction of long-term protective effects against heterologous challenge in SIVhu-infected macaques.
Virology 2000;278(1):194-206.
2000: Pavel Bostik; Gary T Brice; K P Greenberg; Ann Mayne; Francios VILLINGER; Mark G Lewis; Aftab A Ansari
Inverse correlation of telomerase activity/proliferation of CD4+ T lymphocytes and disease progression in simian immunodeficiency virus-infected nonhuman primates.
Journal of acquired immune deficiency syndromes (1999) 2000;24(2):89-99.
2000: Francios VILLINGER; Silvana Bucur; NF Chikkala; Sukhdev S Brar; Pavel Bostik; Ann Mayne; J Adams; ME Lee; Francis J Novembre; M K Gately; Aftab A Ansari; Christopher D Hillyer
In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS.
AIDS research and human retroviruses 2000;16(8):751-63.
2000: Gary T Brice; Ann Mayne; Francios VILLINGER; Aftab A Ansari
A novel role for tumor necrosis factor-alpha in regulating susceptibility of activated CD4+ T cells from human and nonhuman primates for distinct coreceptor using lentiviruses.
Journal of acquired immune deficiency syndromes (1999) 2000;24(1):10-22.
1999: Gary T Brice; Ann Mayne; KL Leighton; Francios VILLINGER; J S Allan; Aftab A Ansari
Studies of CD40L expression by lymphoid cells from experimentally and naturally SIV-infected nonhuman primate species.
Journal of medical primatology 1999;28(2):49-56.
1999: Francios VILLINGER; Gary T Brice; Ann Mayne; Pavel Bostik; Aftab A Ansari
Control mechanisms of virus replication in naturally SIVsmm infected mangabeys and experimentally infected macaques.
Immunology letters 1999;66(1-3):37-46.
1998: Gary T Brice; J L Riley; Francios VILLINGER; Ann Mayne; Christopher D Hillyer; Carl H June; Aftab A Ansari
Development of an animal model for autotransfusion therapy: in vitro characterization and analysis of anti-CD3/CD28 expanded cells.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;19(3):210-20.
1998: Silvana Bucur; D A Lackey; Jonathan W Adams; ME Lee; Francios VILLINGER; Ann Mayne; Robert A. Bray; Elliott F Winton; Francis J Novembre; Elizabeth Strobert; J De Rosayro; P J Dailey; Aftab A Ansari; Christopher D Hillyer
Hematologic and virologic effects of lineage-specific and non-lineage-specific recombinant human and rhesus cytokines in a cohort of SIVmac239-infected macaques.
AIDS research and human retroviruses 1998;14(8):651-60.
1997: Francios VILLINGER; Sukhdev S Brar; Gary T Brice; NF Chikkala; Francis J Novembre; Ann Mayne; Silvana Bucur; Christopher D Hillyer; Aftab A Ansari
Immune and hematopoietic parameters in HIV-1-infected chimpanzees during clinical progression toward AIDS.
Journal of medical primatology 1997;26(1-2):11-8.
1996: Gary T Brice; Francios VILLINGER; Ann Mayne; J Bruce Sundstrom; Aftab A Ansari
Detection of intracellular signal transduction molecules in PBMC from rhesus macaques and sooty mangabeys.
Journal of medical primatology 1996;25(3):210-7.
1996: Francios VILLINGER; Thomas M Folks; S Lauro; Jonathan D Powell; J Bruce Sundstrom; Ann Mayne; Aftab A Ansari
Immunological and virological studies of natural SIV infection of disease-resistant nonhuman primates.
Immunology letters 1996;51(1-2):59-68.
1995: Francios VILLINGER; Sukhdev S Brar; Ann Mayne; NF Chikkala; Aftab A Ansari
Comparative sequence analysis of cytokine genes from human and nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3946-54.
1995: Aftab A Ansari; Ann Mayne; J Bruce Sundstrom; Michael B Gravanis; Kirk R Kanter; K W Sell; Francios VILLINGER; C O Siu; A Herskowitz
Frequency of hypoxanthine guanine phosphoribosyltransferase (HPRT-) T cells in the peripheral blood of cardiac transplant recipients. A noninvasive technique for the diagnosis of allograft rejection.
Circulation 1995;92(4):862-74.
1995: Aftab A Ansari; Ann Mayne; Curt R Freed; Robert E Breeze; S A Schneck; C F O'Brien; E H Kriek; Y B Zhang; J C Mazziotta; M Hutchinson
Lack of a detectable systemic humoral/cellular allogeneic response in human and nonhuman primate recipients of embryonic mesencephalic allografts for the therapy of Parkinson's disease.
Transplantation proceedings 1995;27(1):1401-5.
1995: J Bruce Sundstrom; Ann Mayne; Kirk R Kanter; A Herskowitz; Aftab A Ansari
Mechanisms of human cardiac allograft rejection: absence of co-stimulatory molecules and cell adhesion molecules on major histocompatibility complex class I/II+ human cardiac myocytes does not induce anergy.
Transplantation proceedings 1995;27(1):1310-3.
1995: Aftab A Ansari; J Bruce Sundstrom; Kirk R Kanter; Ann Mayne; Francios VILLINGER; Michael B Gravanis; A Herskowitz
Cellular and molecular mechanisms of human cardiac myocyte injury after transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1995;14(1 Pt 1):102-12.
1994: Aftab A Ansari; N Neckelmann; Francios VILLINGER; Patrick S C Leung; D J Danner; Sukhdev S Brar; S Zhao; Michael B Gravanis; Ann Mayne; M Eric Gershwin
Epitope mapping of the branched chain alpha-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4754-65.
1994: A Herskowitz; Ann Mayne; S B Willoughby; K Kanter; Aftab A Ansari
Patterns of myocardial cell adhesion molecule expression in human endomyocardial biopsies after cardiac transplantation. Induced ICAM-1 and VCAM-1 related to implantation and rejection.
The American journal of pathology 1994;145(5):1082-94.
1994: T Jehuda-Cohen; Jonathan D Powell; Francios VILLINGER; Ann Mayne; K W Sell; Aftab A Ansari
Evidence for simian immunodeficiency virus-specific IgM and IgG response in peripheral blood mononuclear cells of serum enzyme-linked immunosorbent assay-negative nonhuman primates.
Journal of acquired immune deficiency syndromes 1994;7(6):539-50.
1994: Aftab A Ansari; J Bruce Sundstrom; H Runnels; P Jensen; Kirk R Kanter; Ann Mayne; A Herskowitz
The absence of constitutive and induced expression of critical cell-adhesion molecules on human cardiac myocytes. Its role in transplant rejection.
Transplantation 1994;57(6):942-9.
1994: Aftab A Ansari; Ann Mayne; D Hunt; J Bruce Sundstrom; Francios VILLINGER
TH1/TH2 subset analysis. I. Establishment of criteria for subset identification in PBMC samples from nonhuman primates.
Journal of medical primatology 1994;23(2-3):102-7.
1993: Francios VILLINGER; D Hunt; Ann Mayne; M Vuchetich; Harry W Findley; Aftab A Ansari
Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells.
Cytokine 1993;5(5):469-79.
1993: Aftab A Ansari; Y C Wang; Kirk R Kanter; Francios VILLINGER; Ann Mayne; K W Sell; A Herskowitz
Host T-cell primary allosensitization to MHC class-I- and class-II-expressing human cardiac myocytes requires the presence of a second signal.
Human immunology 1993;37(2):108-18.
1993: Aftab A Ansari; Kirk R Kanter; Y C Wang; Ann Mayne; K W Sell; A Herskowitz
Major histocompatibility complex-expressing human cardiac myocytes are not the direct target of host cardiac-infiltrating cells: evidence for a prominent role of the indirect pathway in human cardiac allograft rejection.
Transplantation proceedings 1993;25(1 Pt 1):89-93.
1992: K W Sell; Y C Wang; Kirk R Kanter; Glenn Rodey; Ann Mayne; Aftab A Ansari
Characterization of human heart-infiltrating cells after transplantation. VI. Differences in the cytokines produced by individual CD4+ cloned T-cell lines with apparently identical antiidiotype-like reactivity.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1992;11(3 Pt 1):511-21.
1991: Aftab A Ansari; Y C Wang; D J Danner; Michael B Gravanis; Ann Mayne; N Neckelmann; K W Sell; A Herskowitz
Abnormal expression of histocompatibility and mitochondrial antigens by cardiac tissue from patients with myocarditis and dilated cardiomyopathy.
The American journal of pathology 1991;139(2):337-54.
1991: Aftab A Ansari; Y C Wang; Kirk R Kanter; Glenn Rodey; Ann Mayne; K W Sell
Characterization of human cardiac-infiltrating cells posttransplantation--functional heterogeneity of anti-idiotype cloned T-cell lines with identical idiotype specificity.
Transplantation proceedings 1991;23(1 Pt 1):159-62.
1991: Y C Wang; N Neckelmann; Ann Mayne; A Herskowitz; A Srinivasan; K W Sell; A Ahmed-Ansari
Establishment of a human fetal cardiac myocyte cell line.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1991;27(1):63-74.
1990: Y C Wang; Ann Mayne; K W Sell; A Ahmed-Ansari
The influence of MHC and non-MHC genes on the nature of murine cardiac allograft rejection. I. Kinetic analysis of mononuclear cell infiltrate and MHC-class I/class II expression in donor tissue.
Transplantation 1990;50(2):313-24.