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George R. Uhl

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George R. Uhl
Preface to Addiction Reviews.
Arihisa Ohara; George R. Uhl; Hideko Yamamoto; F Scott Hall; Harumi Hata; Kazutaka Ikeda; Yoshiyuki Kasahara; Hideaki Kobayashi; Ichiro Miyoshi; Yohtaro Numachi; Ichiro Sora
Exclusive expression of VMAT2 in noradrenergic neurons increases viability of homozygous VMAT2 knockout mice.
Stephen Bruehl; Wen G Chen; John T Farrar; Jennifer Haythornthwaite; Susan D Horn; Michael J Iadarola; Charles E Inturrisi; Lixing Lao; A Vania Apkarian; Jane C Ballantyne; Ann Berger; David Borsook; Sean Mackey; Jianren Mao; Andrea Sawczuk; George R. Uhl; James Witter; Clifford J Woolf; Jon K Zubieta; Yu Lin
Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges.

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All Publications

2013: George R. Uhl
Preface to Addiction Reviews.
Annals of the New York Academy of Sciences 2013;1282():iv.
2013: Arihisa Ohara; George R. Uhl; Hideko Yamamoto; F Scott Hall; Harumi Hata; Kazutaka Ikeda; Yoshiyuki Kasahara; Hideaki Kobayashi; Ichiro Miyoshi; Yohtaro Numachi; Ichiro Sora
Exclusive expression of VMAT2 in noradrenergic neurons increases viability of homozygous VMAT2 knockout mice.
Biochemical and biophysical research communications 2013;432(3):526-32.
2013: Stephen Bruehl; Wen G Chen; John T Farrar; Jennifer Haythornthwaite; Susan D Horn; Michael J Iadarola; Charles E Inturrisi; Lixing Lao; A Vania Apkarian; Jane C Ballantyne; Ann Berger; David Borsook; Sean Mackey; Jianren Mao; Andrea Sawczuk; George R. Uhl; James Witter; Clifford J Woolf; Jon K Zubieta; Yu Lin
Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges.
The journal of pain : official journal of the American Pain Society 2013;14(2):103-13.
2013: Esther Berrocoso; Kazutaka Ikeda; Pilar Sánchez-Blázquez; Ichiro Sora; George R. Uhl; Juan Mico
Active behaviours produced by antidepressants and opioids in the mouse tail suspension test.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2013;16(1):151-62.
2013: Maria G A Hägglund; Sofie V Hellsten; Erik Löfqvist; Victor C O Nilsson; Sahar Roshanbin; Helgi B Schiöth; Olof Stephansson; Aniruddha Todkar; George R. Uhl; Yinan Zhu; Jana Drgonova; Robert Fredriksson
B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain.
PloS one 2013;8(3):e58651.
2013: Joseph J Gallagher; F Scott Hall; George R. Uhl; Xiaowei Zhang; Elaine L Bearer; Russell E Jacobs
Altered reward circuitry in the norepinephrine transporter knockout mouse.
PloS one 2013;8(3):e57597.
2013: Osamu Uchiumi; George R. Uhl; Asami Fukui; F Scott Hall; Yoshiyuki Kasahara; Ichiro Sora
Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine.
Neuropharmacology 2013;64():348-56.
2012: Junichi Kitanaka; Nobue Kitanaka; Nobuyoshi Nishiyama; F Scott Hall; Koh-Ichi Tanaka; George R. Uhl; Motohiko Takemura
Straub tail reaction in mice treated with σ(1) receptor antagonist in combination with methamphetamine.
Brain research 2012;1482():40-6.
2012: Yosefu Arime; F Scott Hall; Yoshiyuki Kasahara; George R. Uhl; Ichiro Sora
Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(11):2522-30.
2012: Epolia Ramadan; Stanley I Rapoport; George R. Uhl; Lisa Chang; Mei Chen; F Scott Hall; Kaizong Ma; Mireille Basselin
Knocking out the dopamine reuptake transporter (DAT) does not change the baseline brain arachidonic acid signal in the mouse.
The International journal of neuroscience 2012;122(7):373-80.
2012: Marcus R Munafò; Sandosh Padmanabhan; Tom M Palmer; David Prieto-Merino; Caroline Relton; Elio Riboli; Naveed Sattar; Maria N Timofeeva; Nicholas J Timpson; George R. Uhl; Mark N Upton; Paolo Vineis; Donna Walther; Graham Watt; Peter H Whincup; Antoinette Amuzu; Paul Aveyard; Paul Brennan; Juan P Casas; Shah Ebrahim; Aroon D Hingorani; Barbara J Jefferis; Paul C D Johnson; Elaine C Johnstone; Richard W Morris; George Davey Smith
Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure.
Journal of the National Cancer Institute 2012;104(10):740-8.
2012: Junichi Kitanaka; Nobue Kitanaka; Nobuyoshi Nishiyama; Hiromi Asano; Ryuki Chatani; F Scott Hall; Sachiko Hayata; Koh-Ichi Tanaka; George R. Uhl; Hiroko Yokoyama; Motohiko Takemura
Pretreatment with nomifensine or nomifensine analogue 4-phenyl-1,2,3,4-tetrahydroisoquinoline augments methamphetamine-induced stereotypical behavior in mice.
Brain research 2012;1439():15-26.
2012: F Scott Hall; Edward D Levin; Athina Markou; George R. Uhl
Mouse models for studying genetic influences on factors determining smoking cessation success in humans.
Annals of the New York Academy of Sciences 2012;1248():39-70.
2012: A M Leventhal; Elizabeth E Lloyd-Richardson; J E McGeary; Marcus R Munafò; M Brightman; R A Brown; Sean P David; David Strong; George R. Uhl; Raymond Niaura
Dopamine D4 receptor gene variation moderates the efficacy of bupropion for smoking cessation.
The pharmacogenomics journal 2012;12(1):86-92.
2012: Nobue Kitanaka; Hitoshi Kubo; Yoshio Morita; Hitoshi Takahashi; F Scott Hall; Junichi Kitanaka; Tomohiro Tatsuta; George R. Uhl; Kaname Watabe; Motohiko Takemura
A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.
Brain research 2012;1429():155-63.
2012: F Scott Hall; Jordan Adair; Paul R Dobner; Marjorie Centeno; Maria T G Perona; George R. Uhl
Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine.
Psychopharmacology 2012;219(1):35-45.
2011: George R. Uhl; Donna Walther; Frederique M Behm; Jed E Rose
Menthol preference among smokers: association with TRPA1 variants.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2011;13(12):1311-5.
2011: Hiroshi Komatsu; Arihisa Ohara; Kazumasu Sasaki; Hiromi Abe; F Scott Hall; Hisaki Hattori; George R. Uhl; Ichiro Sora
Decreased response to social defeat stress in μ-opioid-receptor knockout mice.
Pharmacology, biochemistry, and behavior 2011;99(4):676-82.
2011: Marcus R Munafò; Michael F G Murphy; George R. Uhl; Donna Walther; Elaine C Johnstone; Paul Aveyard
CHRNA3 rs1051730 genotype and short-term smoking cessation.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2011;13(10):982-8.
2011: Junichi Kitanaka; Nobue Kitanaka; Yoshio Morita; Nobuyoshi Nishiyama; Koh-ichi Tanaka; Tomohiro Tatsuta; George R. Uhl; F Scott Hall; Motohiko Takemura
Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine.
Neurochemical research 2011;36(10):1824-33.
2011: Vorani Ramachandra; Francis Kang; Christine Kim; Alan S Nova; Ankur Bajaj; George R. Uhl; F Scott Hall; Rueben A Gonzales
The μ opioid receptor is not involved in ethanol-stimulated dopamine release in the ventral striatum of C57BL/6J mice.
Alcoholism, clinical and experimental research 2011;35(5):929-38.
2011: Teodora-Adriana Perles-Barbacaru; Daniel Procissi; Andrey V Demyanenko; F Scott Hall; George R. Uhl; Russell E Jacobs
Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice.
NeuroImage 2011;55(2):622-8.
2011: Shinya Kasai; Ichiro Sora; George R. Uhl; Masahiko Watanabe; Hideko Yamamoto; Etsuko Kamegaya; Kazutaka Ikeda
Quantitative Detection of µ Opioid Receptor: Western Blot Analyses Using µ Opioid Receptor Knockout Mice.
Current neuropharmacology 2011;9(1):219-22.
2011: Yoko Hagino; T Iwamura; D L Murphy; Ichiro Sora; Yukio Takamatsu; George R. Uhl; Hideko Yamamoto; Kazutaka Ikeda
Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters.
Current neuropharmacology 2011;9(1):91-5.
2011: Tomas Drgon; Catherine A Johnson; Michelle Nino; Jana Drgonova; Donna Walther; George R. Uhl
"Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156(2):125-38.
2011: F Scott Hall; J M Schwarzbaum; M T G Perona; J S Templin; Marc G Caron; Klaus-Peter Lesch; Dennis L Murphy; George R. Uhl
A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception.
Neuroscience 2011;175():315-27.
2011: Chuan-Yun Li; Liping Wei; Pingwu Zhang; Wei-Zhen Zhou; Catherine Johnson; George R. Uhl
Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction.
BMC genomics 2011;12():508.
2011: Catherine Johnson; Tomas Drgon; Donna Walther; George R. Uhl
Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.
PloS one 2011;6(7):e19210.
2011: Soichiro Ide; Masabumi Minami; George R. Uhl; Masamichi Satoh; Ichiro Sora; Kazutaka Ikeda
(-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice.
Molecular pain 2011;7():23.
2011: George R. Uhl
Addiction reviews. Preface.
Annals of the New York Academy of Sciences 2011;1216():vii-viii.
2010: George R. Uhl; Tomas Drgon; Catherine Johnson; Marco F Ramoni; Frederique M Behm; Jed E Rose
Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.
Molecular medicine (Cambridge, Mass.) 2010;16(11-12):513-26.
2010: Matthew J Chiocco; Xuguang Zhu; Donna Walther; Olga Pletnikova; Juan C Troncoso; George R. Uhl; Qingrong Liu
Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
Substance use & misuse 2010;45(11):1809-26.
2010: Xiangru Xu; Mohamed R Mughal; F Scott Hall; Maria T G Perona; Paul J Pistell; Justin D Lathia; Srinivasulu Chigurupati; Kevin G Becker; Bruce Ladenheim; Laura E Niklason; George R. Uhl; Jean Lud Cadet; Mark P Mattson
Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior.
Journal of neurochemistry 2010;114(1):323-34.
2010: Jed E Rose; Frederique M Behm; Tomas Drgon; Catherine Johnson; George R. Uhl
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Molecular medicine (Cambridge, Mass.) 2010;16(7-8):247-53.
2010: Chuan-Yun Li; Yong Zhang; Zhanbo Wang; Yan Zhang; Chunmei Cao; Pingwu Zhang; Shu-Juan Lu; Xiao-Mo Li; Quan Yu; Xiaofeng Zheng; Quan Du; George R. Uhl; Qingrong Liu; Liping Wei
A human-specific de novo protein-coding gene associated with human brain functions.
PLoS computational biology 2010;6(3):e1000734.
2010: George R. Uhl; Tomas Drgon; Catherine Johnson; Donna Walther; Sean P David; Paul Aveyard; Michael Murphy; Elaine C Johnstone; Marcus R Munafò
Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement.
Pharmacogenomics 2010;11(3):357-67.
2010: Sean P David; Briana Mezuk; Peter P Zandi; David Strong; James C Anthony; Raymond Niaura; George R. Uhl; William W Eaton
Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2010;12(3):251-62.
2010: Bingjin Li; Yosefu Arime; F Scott Hall; George R. Uhl; Ichiro Sora
Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice.
European journal of pharmacology 2010;628(1-3):104-7.
2010: Jana Drgonova; D B Zimonjic; F Scott Hall; George R. Uhl
Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus.
Neuroscience 2010;165(3):882-95.
2010: George R. Uhl
Introduction to Addiction Reviews 2.
Annals of the New York Academy of Sciences 2010;1187():1-2.
2010: Jermaine D Jones; F Scott Hall; George R. Uhl; Anthony L Riley
Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion.
Pharmacology, biochemistry, and behavior 2010;94(4):580-7.
2010: Soichiro Ide; Shunsuke Fujiwara; Masayuki Fujiwara; Ichiro Sora; Kazutaka Ikeda; Masabumi Minami; George R. Uhl; Kumatoshi Ishihara
Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice.
Journal of pharmacological sciences 2010;114(1):107-10.
2010: Xiaowei Zhang; Elaine L Bearer; Benoit Boulat; F Scott Hall; George R. Uhl; Russell E Jacobs
Altered neurocircuitry in the dopamine transporter knockout mouse brain.
PloS one 2010;5(7):e11506.
2010: Tomas Drgon; Pingwu Zhang; Catherine Johnson; Donna Walther; Judith Hess; Michelle Nino; George R. Uhl
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
PloS one 2010;5(1):e8832.
2010: Soichiro Ide; Ichiro Sora; Kazutaka Ikeda; Masabumi Minami; George R. Uhl; Kumatoshi Ishihara
Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice.
Neuropharmacology 2010;58(1):241-7.
2009: George R. Uhl; Tomas Drgon; Chuan-Yun Li; Catherine Johnson; Qingrong Liu
Smoking and smoking cessation in disadvantaged women: assessing genetic contributions.
Drug and alcohol dependence 2009;104 Suppl 1():S58-63.
2009: F Scott Hall; Xiao-Fei Li; J Randall-Thompson; Ichiro Sora; Dennis L Murphy; Klaus-Peter Lesch; M Caron; George R. Uhl
Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice.
Neuroscience 2009;162(4):870-80.
2009: George R. Uhl
Promise of pharmacogenomics in smoking cessation.
Pharmacogenomics 2009;10(7):1123-5.
2009: Tomas Drgon; Catherine Johnson; Donna Walther; Anthony P Albino; Jed E Rose; George R. Uhl
Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes.
Molecular medicine (Cambridge, Mass.) 2009;15(7-8):268-74.
2009: Qingrong Liu; C-H Pan; Akitoyo Hishimoto; Chuan-Yun Li; Zheng-Xiong Xi; A Llorente-Berzal; Maria Paz Viveros; Hiroki Ishiguro; Tadao Arinami; Emmanuel S Onaivi; George R. Uhl
Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands.
Genes, brain, and behavior 2009;8(5):519-30.
2009: Jermaine D Jones; F Scott Hall; George R. Uhl; Kenner Rice; Anthony L Riley
Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.
Pharmacology, biochemistry, and behavior 2009;93(1):75-81.
2009: Junichi Kitanaka; Nobue Kitanaka; Tomohiro Tatsuta; F S Hall; George R. Uhl; K Tanaka; N Nishiyama; Yoshio Morita; Motohiko Takemura
Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice.
Psychopharmacology 2009;203(4):781-92.
2009: George R. Uhl; Tomas Drgon; Catherine Johnson; Jed E Rose
Nicotine abstinence genotyping: assessing the impact on smoking cessation clinical trials.
The pharmacogenomics journal 2009;9(2):111-5.
2009: Keisuke Hashimoto; Taku Amano; Akiko Kasakura; George R. Uhl; Ichiro Sora; Norio Sakai; Naoko Kuzumaki; Tsutomu Suzuki; Minoru Narita
mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons.
Neuroscience letters 2009;453(1):62-7.
2009: Catherine Johnson; Tomas Drgon; Francis McMajon; George R. Uhl
Convergent genome wide association results for bipolar disorder and substance dependence.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(2):182-90.
2009: Morgane Thomsen; F Scott Hall; George R. Uhl; S Barak Caine
Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):1087-92.
2009: Scott F Saccone; Laura J Bierut; Elissa J Chesler; Peter W Kalivas; Caryn Lerman; Nancy L Saccone; George R. Uhl; Chuan-Yun Li; Vivek M Philip; Howard J Edenberg; Stephen T Sherry; Michael Feolo; Robert K Moyzis; Joni L Rutter
Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm.
PloS one 2009;4(4):e5225.
2009: George R. Uhl; Tomas Drgon; Catherine Johnson; Qingrong Liu
Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence.
Journal of neurogenetics 2009;23(3):272-82.
2009: Tomas Drgon; Ivan Montoya; Catherine Johnson; Qingrong Liu; Donna Walther; Dean Hamer; George R. Uhl
Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers.
Molecular medicine (Cambridge, Mass.) 2009;15(1-2):21-7.
2009: Chuan-Yun Li; Qingrong Liu; Pingwu Zhang; Xiao-Mo Li; Liping Wei; George R. Uhl
OKCAM: an ontology-based, human-centered knowledgebase for cell adhesion molecules.
Nucleic acids research 2009;37(Database issue):D251-60.
2008: Hiroki Ishiguro; Jian-Ping Gong; F Scott Hall; Tadao Arinami; George R. Uhl
Association of PTPRB gene polymorphism with drug addiction.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(7):1167-72.
2008: George R. Uhl; Tomas Drgon; Catherine Johnson; Chuan-Yun Li; Carlo Contoreggi; Judith Hess; Daniel Naiman; Qingrong Liu
Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
Annals of the New York Academy of Sciences 2008;1141():318-81.
2008: George R. Uhl
Addiction Reviews. Preface.
Annals of the New York Academy of Sciences 2008;1141():ix-x.
2008: Emmanuel S Onaivi; Hiroki Ishiguro; Jian-Ping Gong; Sejal Patel; Paul A Meozzi; Lester Myers; Alex Perchuk; Zoila Mora; Patricia Tagliaferro; Eileen Gardner; Alicia Brusco; B Emmanuel Akinshola; Qingrong Liu; Sanika Chirwa; Bruce T Hope; Javier Lujilde; Toshiya Inada; Shinya Iwasaki; David Macharia; Lindsey Teasenfitz; Tadao Arinami; George R. Uhl
Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression.
Annals of the New York Academy of Sciences 2008;1139():434-49.
2008: Emmanuel S Onaivi; O Carpio; Hiroki Ishiguro; Norman Schanz; George R. Uhl; R Benno
Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.
Annals of the New York Academy of Sciences 2008;1139():426-33.
2008: Maria T G Perona; Shonna Waters; F Scott Hall; Ichiro Sora; Klaus-Peter Lesch; Dennis L Murphy; Marc Caron; George R. Uhl
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions.
Behavioural pharmacology 2008;19(5-6):566-74.
2008: Nobue Kitanaka; Junichi Kitanaka; F Scott Hall; Tomohiro Tatsuta; Yoshio Morita; Motohiko Takemura; Xiao-Bing Wang; George R. Uhl
Alterations in the levels of heterotrimeric G protein subunits induced by psychostimulants, opiates, barbiturates, and ethanol: Implications for drug dependence, tolerance, and withdrawal.
Synapse (New York, N.Y.) 2008;62(9):689-99.
2008: Joan C Han; Qingrong Liu; MaryPat Jones; Rebecca L Levinn; Carolyn M Menzie; Kyra S Jefferson-George; Diane C Adler-Wailes; Ethan L Sanford; Felicitas L Lacbawan; George R. Uhl; Owen Rennert; Jack A Yanovski
Brain-derived neurotrophic factor and obesity in the WAGR syndrome.
The New England journal of medicine 2008;359(9):918-27.
2008: George R. Uhl
Dr George Uhl speaks to Shreeya Nanda, commissioning editor.
Pharmacogenomics 2008;9(7):813-7.
2008: George R. Uhl; Qingrong Liu; Tomas Drgon; Catherine Johnson; Donna Walther; Jed E Rose; Sean P David; Ray Niaura; Caryn Lerman
Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Archives of general psychiatry 2008;65(6):683-93.
2008: Soichiro Ide; Masabumi Minami; Kumatoshi Ishihara; George R. Uhl; Masamichi Satoh; Ichiro Sora; Kazutaka Ikeda
Abolished thermal and mechanical antinociception but retained visceral chemical antinociception induced by butorphanol in mu-opioid receptor knockout mice.
Neuropharmacology 2008;54(8):1182-8.
2008: George R. Uhl; Tomas Drgon; Qingrong Liu; Catherine Johnson; Donna Walther; Tokutaro Komiyama; Mutsuo Harano; Yoshimoto Sekine; Toshiya Inada; Norio Ozaki; Masaomi Iyo; Nakao Iwata; Mitsuhiko Yamada; Ichiro Sora; Chih-Ken Chen; Hsing-Cheng Liu; Hiroshi Ujike; Shih-Ku Lin
Genome-wide association for methamphetamine dependence: convergent results from 2 samples.
Archives of general psychiatry 2008;65(3):345-55.
2008: Catherine Johnson; Tomas Drgon; Qingrong Liu; Pingwu Zhang; Donna Walther; Chuan-Yun Li; James C Anthony; YULAN DING; William W Eaton; George R. Uhl
Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples.
BMC medical genetics 2008;9():113.
2008: Emmanuel S Onaivi; Hiroki Ishiguro; Jian-Ping Gong; Sejal Patel; Paul A Meozzi; Lester Myers; Alex Perchuk; Zoila Mora; Patricia Tagliaferro; Eileen Gardner; Alicia Brusco; B Emmanuel Akinshola; Bruce T Hope; Javier Lujilde; Toshiya Inada; Shinya Iwasaki; David Macharia; Lindsey Teasenfitz; Tadao Arinami; George R. Uhl
Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.
PloS one 2008;3(2):e1640.
2008: George R. Uhl; Tomas Drgon; Catherine Johnson; Oluwatosin O Fatusin; Qingrong Liu; Carlo Contoreggi; Chuan-Yun Li; Kari J Buck; John C Crabbe
"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.
Biochemical pharmacology 2008;75(1):98-111.
2007: Jana Drgonova; Qingrong Liu; F Scott Hall; Rachael M Krieger; George R. Uhl
Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.
Brain research 2007;1183():10-20.
2007: Akitoyo Hishimoto; Qingrong Liu; Tomas Drgon; Olga Pletnikova; Donna Walther; Xu-Guang Zhu; Juan C Troncoso; George R. Uhl
Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms.
Human molecular genetics 2007;16(23):2880-91.
2007: Yohtaro Numachi; Arihisa Ohara; Motoyasu Yamashita; Setsu Fukushima; Hideaki Kobayashi; Harumi Hata; Hidekazu Watanabe; F Scott Hall; Klaus-Peter Lesch; Dennis L Murphy; George R. Uhl; Ichiro Sora
Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.
European journal of pharmacology 2007;572(2-3):120-8.
2007: Martin O Job; Amanda Tang; F Scott Hall; Ichiro Sora; George R. Uhl; Susan E Bergeson; Rueben A Gonzales
Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis.
Biological psychiatry 2007;62(6):627-34.
2007: Hiroki Ishiguro; Donna Walther; Tadao Arinami; George R. Uhl
Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples.
Addiction (Abingdon, England) 2007;102(8):1320-5.
2007: Hideko Yamamoto; Etsuko Kamegaya; Yoko Hagino; Kazuhide Imai; Akihiro Fujikawa; Kohei Tamura; Tomoyuki Enokiya; Toshifumi Yamamoto; Takao Takeshima; Hisashi Koga; George R. Uhl; Kazutaka Ikeda; Ichiro Sora
Genetic deletion of vesicular monoamine transporter-2 (VMAT2) reduces dopamine transporter activity in mesencephalic neurons in primary culture.
Neurochemistry international 2007;51(2-4):237-44.
2007: Philip Seeman; F Scott Hall; George R. Uhl
Increased dopamine D2High receptors in knockouts of the dopamine transporter and the vesicular monoamine transporter may contribute to spontaneous hyperactivity and dopamine supersensitivity.
Synapse (New York, N.Y.) 2007;61(7):573-6.
2007: Setsu Fukushima; Haowei Shen; Harumi Hata; Arihisa Ohara; Kayo Ohmi; Kazutaka Ikeda; Yohtaro Numachi; Hideaki Kobayashi; F Scott Hall; George R. Uhl; Ichiro Sora
Methamphetamine-induced locomotor activity and sensitization in dopamine transporter and vesicular monoamine transporter 2 double mutant mice.
Psychopharmacology 2007;193(1):55-62.
2007: George R. Uhl
Premature poking: impulsivity, cocaine and dopamine.
Nature medicine 2007;13(4):413-4.
2007: Gwyndolen C Harburg; F S Hall; Alexia V Harrist; I Sora; George R. Uhl; Amelia J Eisch
Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons.
Neuroscience 2007;144(1):77-87.
2007: George R. Uhl; Qingrong Liu; Tomas Drgon; Catherine Johnson; Donna Walther; Jed E Rose
Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs.
BMC genetics 2007;8():10.
2006: Qingrong Liu; Tomas Drgon; Catherine Johnson; Donna Walther; Judith Hess; George R. Uhl
Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(8):918-25.
2006: Catherine Johnson; Tomas Drgon; Qingrong Liu; Donna Walther; Howard J Edenberg; John Rice; Tatiana Foroud; George R. Uhl
Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(8):844-53.
2006: Tomas Drgon; Claudio D'Addario; George R. Uhl
Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(8):854-60.
2006: Motoyasu Yamashita; Setsu Fukushima; Hao-Wei Shen; F Scott Hall; George R. Uhl; Yohtaro Numachi; Hideaki Kobayashi; Ichiro Sora
Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(10):2132-9.
2006: Soichiro Ide; Masabumi Minami; Kumatoshi Ishihara; George R. Uhl; Ichiro Sora; Kazutaka Ikeda
Mu opioid receptor-dependent and independent components in effects of tramadol.
Neuropharmacology 2006;51(3):651-8.
2006: Emmanuel S Onaivi; Hiroki Ishiguro; Jian-Ping Gong; Sejal Patel; Alex Perchuk; Paul A Meozzi; Lester Myers; Zoila Mora; Patricia Tagliaferro; Eileen Gardner; Alicia Brusco; B Emmanuel Akinshola; Qingrong Liu; Bruce T Hope; Shinya Iwasaki; Tadao Arinami; Lindsey Teasenfitz; George R. Uhl
Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain.
Annals of the New York Academy of Sciences 2006;1074():514-36.
2006: George R. Uhl
Molecular genetics of addiction vulnerability.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006;3(3):295-301.
2006: Tomas Drgon; Zhicheng Lin; Gene-Jack Wang; Joanna S Fowler; John Pablo; Deborah C Mash; Nora D Volkow; George R. Uhl
Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo.
Cellular and molecular neurobiology 2006;26(4-6):875-89.
2006: Wenhua Han; Harumi Hata; H Imbe; Qingrong Liu; Yukio Takamatsu; Miwako Koizumi; Niall P Murphy; Emiko Senba; George R. Uhl; Ichiro Sora; Kazutaka Ikeda
Increased body weight in mice lacking mu-opioid receptors.
Neuroreport 2006;17(9):941-4.
2006: Wenhua Han; Shinya Kasai; Harumi Hata; Takehiro Takahashi; Yukio Takamatsu; Hideko Yamamoto; George R. Uhl; Ichiro Sora; Kazutaka Ikeda
Intracisternal A-particle element in the 3' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivity.
Pharmacogenetics and genomics 2006;16(6):451-60.
2006: Dalit E Dar; Thomas G Metzger; David J Vandenbergh; George R. Uhl
Dopamine uptake and cocaine binding mechanisms: the involvement of charged amino acids from the transmembrane domains of the human dopamine transporter.
European journal of pharmacology 2006;538(1-3):43-7.
2006: Hiroaki Yamada; Naohito Shimoyama; Ichiro Sora; George R. Uhl; Yasuichiro Fukuda; Hideshige Moriya; Megumi Shimoyama
Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors.
Brain research 2006;1083(1):61-9.
2006: Hiroki Ishiguro; Qingrong Liu; Jian-Ping Gong; F Scott Hall; Hiroshi Ujike; Marisela Morales; Takeshi Sakurai; Martin Grumet; George R. Uhl
NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(3):572-84.
2006: Hsiang-En Wu; Han-Sen Sun; Maia Terashivili; Emma T Schwasinger; Ichiro Sora; F Scott Hall; George R. Uhl; Leon F Tseng
dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice.
European journal of pharmacology 2006;531(1-3):103-7.
2006: Jian-Ping Gong; Emmanuel S Onaivi; Hiroki Ishiguro; Qingrong Liu; Patricia Tagliaferro; Alicia Brusco; George R. Uhl
Cannabinoid CB2 receptors: immunohistochemical localization in rat brain.
Brain research 2006;1071(1):10-23.
2006: Qingrong Liu; Lin Lu; Xu-Guang Zhu; Jian-Ping Gong; Yavin Shaham; George R. Uhl
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine.
Brain research 2006;1067(1):1-12.
2006: Emmanuel S Onaivi; Hiroki Ishiguro; Patel Sejal; Paul A Meozzi; Lester Myers; Patricia Tagliaferro; Bruce Hope; Claire M Leonard; George R. Uhl; Alicia Brusco; Eileen Gardner
Methods to study the behavioral effects and expression of CB2 cannabinoid receptor and its gene transcripts in the chronic mild stress model of depression.
Methods in molecular medicine 2006;123():291-8.
2006: Ester Fride; Alex Perchuk; F Scott Hall; George R. Uhl; Emmanuel S Onaivi
Behavioral methods in cannabinoid research.
Methods in molecular medicine 2006;123():269-90.
2006: George R. Uhl; Hiroki Ishiguro; Emmanuel S Onaivi; Pingwu Zhang; B Emmanuel Akinshola; Zhicheng Lin; Bruce Hope; Claire M Leonard; Qingrong Liu
Molecular neurobiological methods in marijuana-cannabinoid research.
Methods in molecular medicine 2006;123():1-17.
2005: Dalit E Dar; M Thiruvazhi; P Abraham; S Kitayama; Theresa A Kopajtic; A Gamliel; Barbara Slusher; Frank carroll; George R. Uhl
Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor.
European journal of medicinal chemistry 2005;40(10):1013-21.
2005: Qingrong Liu; Tomas Drgon; Donna Walther; Catherine Johnson; Oxanna Poleskaya; Judith Hess; George R. Uhl
Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11864-9.
2005: Dalit E Dar; Cheryl Mayo; George R. Uhl
The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands.
Biochemical pharmacology 2005;70(3):461-9.
2005: Zhicheng Lin; George R. Uhl
Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter.
Journal of neurochemistry 2005;94(1):276-87.
2005: Kazutaka Ikeda; Soichiro Ide; Wenhua Han; Masakazu Hayashida; George R. Uhl; Ichiro Sora
How individual sensitivity to opiates can be predicted by gene analyses.
Trends in pharmacological sciences 2005;26(6):311-7.
2005: Zhicheng Lin; Donna Walther; Xiao-Ying Yu; Suxia Li; Tomas Drgon; George R. Uhl
SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism.
Human molecular genetics 2005;14(10):1393-404.
2005: Subroto Ghose; Masahiro Fujita; Paul Morrison; George R. Uhl; Dennis L Murphy; P David Mozley; Magnus Schou; Christer Halldin; Robert B Innis
Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters.
Synapse (New York, N.Y.) 2005;56(2):100-4.
2005: Qingrong Liu; Donna Walther; Tomas Drgon; Oksana Polesskaya; Timothy G Lesnick; Kari J Strain; Mariza de Andrade; James H Bower; Demetrius M Maraganore; George R. Uhl
Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;134B(1):93-103.
2005: Qingrong Liu; Jian-Ping Gong; George R. Uhl
Families of protein phosphatase 1 modulators activated by protein kinases a and C: focus on brain.
Progress in nucleic acid research and molecular biology 2005;79():371-404.
2005: Jian-Ping Gong; Qingrong Liu; Pingwu Zhang; Y Wang; George R. Uhl
Mouse brain localization of the protein kinase C-enhanced phosphatase 1 inhibitor KEPI (kinase C-enhanced PP1 inhibitor).
Neuroscience 2005;132(3):713-27.
2004: Zhicheng Lin; Donna Walther; Xiao-Ying Yu; Tomas Drgon; George R. Uhl
The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse.
Pharmacogenetics 2004;14(12):805-11.
2004: Naoyuki Hironaka; Kazutaka Ikeda; Ichiro Sora; George R. Uhl; Hiroaki Niki
Food-reinforced operant behavior in dopamine transporter knockout mice: enhanced resistance to extinction.
Annals of the New York Academy of Sciences 2004;1025():140-5.
2004: F Scott Hall; Ichiro Sora; Jana Drgonova; Xiao-Fei Li; Michelle Goeb; George R. Uhl
Molecular mechanisms underlying the rewarding effects of cocaine.
Annals of the New York Academy of Sciences 2004;1025():47-56.
2004: George R. Uhl
Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results.
Annals of the New York Academy of Sciences 2004;1025():1-13.
2004: Pingwu Zhang; Hiroki Ishiguro; T Ohtsuki; Judith Hess; F Carillo; Donna Walther; Emmanuel S Onaivi; Tadao Arinami; George R. Uhl
Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.
Molecular psychiatry 2004;9(10):916-31.
2004: Hao-Wei Shen; Yoko Hagino; Hideaki Kobayashi; Keiko Shinohara-Tanaka; Kazutaka Ikeda; Hideko Yamamoto; Toshifumi Yamamoto; Klaus-Peter Lesch; Dennis L Murphy; F Scott Hall; George R. Uhl; Ichiro Sora
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(10):1790-9.
2004: Soichiro Ide; Masabumi Minami; Masamichi Satoh; George R. Uhl; Ichiro Sora; Kazutaka Ikeda
Buprenorphine antinociception is abolished, but naloxone-sensitive reward is retained, in mu-opioid receptor knockout mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(9):1656-63.
2004: Wade Berrettini; Laura J Bierut; Thomas J Crowley; Joseph F Cubells; Joseph Frascella; Joel Gelernter; John K Hewitt; Mary Jeanne Kreek; Herbert M Lachman; Mark Leppert; Ming D Li; Pamela Madden; Cindy Miner; Jonathan D Pollock; Ovide F Pomerleau; John P Rice; Joni L Rutter; David Shurtleff; Gary E Swan; Jay A Tischfield; Ming Tsuang; George R. Uhl; Michael Vanyukov; Nora D Volkow; Kay Wanke
Setting priorities for genomic research.
Science (New York, N.Y.) 2004;304(5676):1445-7; author reply 1445-7.
2004: Aleksandras Radzius; Joseph Gallo; David A Gorelick; Jean Lud Cadet; George R. Uhl; Jack E Henningfield; Eric T. Moolchan
Nicotine dependence criteria of the DIS and DSM-III-R: a factor analysis.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2004;6(2):303-8.
2004: Toshihiro Dohi; Shigeo Kitayama; Norimitsu Morioka; Kei Kumagai; Chieko Mitsuhata; Katsuya Morita; Katsuyuki Kozai; Zhicheng Lin; George R. Uhl
Regulation of dopamine and MPP+ transport by catecholamine transporters.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2004;24(2):43-7.
2004: Heikki Mansikka; Chengshui Zhao; Rishi N Sheth; Ichiro Sora; George R. Uhl; Srinivasa N Raja
Nerve injury induces a tonic bilateral mu-opioid receptor-mediated inhibitory effect on mechanical allodynia in mice.
Anesthesiology 2004;100(4):912-21.
2004: George R. Uhl; Robert W Grow
The burden of complex genetics in brain disorders.
Archives of general psychiatry 2004;61(3):223-9.
2004: F Scott Hall; Michelle Goeb; Xiao-Fei Li; Ichiro Sora; George R. Uhl
mu-Opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion.
Brain research. Molecular brain research 2004;121(1-2):123-30.
2004: George R. Uhl
Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process.
Neuropharmacology 2004;47 Suppl 1():140-7.
2004: Qingrong Liu; Pingwu Zhang; Zhicheng Lin; Qi-Fu Li; Amina S Woods; Juan C Troncoso; George R. Uhl
GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.
The Biochemical journal 2004;377(Pt 1):171-81.
2003: Hirokazu Mizoguchi; Hsiang-En Wu; Minoru Narita; Ichiro Sora; Scott F Hall; George R. Uhl; Horace H Loh; Hiroshi Nagase; Leon F Tseng
Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.
Journal of pharmacological sciences 2003;93(4):423-9.
2003: Dennis L Murphy; George R. Uhl; Andrew Holmes; Renee F Ren-Patterson; F Scott Hall; I Sora; Sevilla D Detera-Wadleigh; Klaus-Peter Lesch
Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders.
Genes, brain, and behavior 2003;2(6):350-64.
2003: George R. Uhl; Zhicheng Lin
The top 20 dopamine transporter mutants: structure-function relationships and cocaine actions.
European journal of pharmacology 2003;479(1-3):71-82.
2003: George R. Uhl
Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2003;18 Suppl 7():S71-80.
2003: Nobue Kitanaka; Junichi Kitanaka; Donna Walther; Xiao-Bing Wang; George R. Uhl
Comparative inter-strain sequence analysis of the putative regulatory region of murine psychostimulant-regulated gene GNB1 (G protein beta 1 subunit gene).
DNA sequence : the journal of DNA sequencing and mapping 2003;14(4):257-63.
2003: F Scott Hall; Jana Drgonova; Michelle Goeb; George R. Uhl
Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(8):1485-90.
2003: George R. Uhl
Are over-simplified views of addiction neuroscience providing too simplified ethical considerations?
Addiction (Abingdon, England) 2003;98(7):872-3.
2003: George R. Uhl
Needed: mouse/human cross validation of reinstatement/relapse models (and drug reward models) to model human substance abuse vulnerability allelic variants.
Psychopharmacology 2003;168(1-2):42-3.
2003: Zhicheng Lin; Pingwu Zhang; Xuguang Zhu; Jean-Marc Melgari; Robin Huff; Rachel L Spieldoch; George R. Uhl
Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites.
The Journal of biological chemistry 2003;278(22):20162-70.
2003: F Scott Hall; Xiao-Fei Li; Michelle Goeb; S Roff; H Hoggatt; Ichiro Sora; George R. Uhl
Congenic C57BL/6 mu opiate receptor (MOR) knockout mice: baseline and opiate effects.
Genes, brain, and behavior 2003;2(2):114-21.
2003: Aleksandras Radzius; Joseph John Gallo; David H Epstein; David A Gorelick; Jean Lud Cadet; George R. Uhl; Eric T. Moolchan
A factor analysis of the Fagerström Test for Nicotine Dependence (FTND).
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2003;5(2):255-40.
2003: F Scott Hall; Ichiro Sora; George R. Uhl
Sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) knockout mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(4):620-8.
2003: Jonathan P Wisor; SW Wurts; F S Hall; K P Lesch; D L Murphy; George R. Uhl; Dale M Edgar
Altered rapid eye movement sleep timing in serotonin transporter knockout mice.
Neuroreport 2003;14(2):233-8.
2003: Zhicheng Lin; George R. Uhl
Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities.
The pharmacogenomics journal 2003;3(3):159-68.
2003: Boris P Sokolov; Oksana Polesskaya; George R. Uhl
Mouse brain gene expression changes after acute and chronic amphetamine.
Journal of neurochemistry 2003;84(2):244-52.
2002: L Lin; J Wisor; T Shiba; S Taheri; K Yanai; S Wurts; X Lin; M Vitaterna; J Takahashi; T W Lovenberg; M Koehl; George R. Uhl; S Nishino; E Mignot
Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background.
Peptides 2002;23(12):2203-11.
2002: Masanari Itokawa; Zhicheng Lin; George R. Uhl
Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations.
Brain research. Molecular brain research 2002;108(1-2):71-80.
2002: Yan Zhou; Rudolph Spangler; Stefan D Schlussman; Vadim Yuferov; Ichiro Sora; Ann Ho; George R. Uhl; Mary Jeanne Kreek
Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice.
Synapse (New York, N.Y.) 2002;45(4):220-9.
2002: George R. Uhl; Qingrong Liu; Daniel Naiman
Substance abuse vulnerability loci: converging genome scanning data.
Trends in genetics : TIG 2002;18(8):420-5.
2002: J Eric Ahlskog; Demetrius M Maraganore; Ryan Uitti; George R. Uhl
Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease.
JAMA : the journal of the American Medical Association 2002;288(3):311; author reply 312-3.
2002: Qingrong Liu; Pingwu Zhang; Qiaoxi Zhen; Donna Walther; Xiao-Bing Wang; George R. Uhl
KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
The Journal of biological chemistry 2002;277(15):13312-20.
2002: Emmanuel S Onaivi; Claire M Leonard; Hiroki Ishiguro; Pingwu Zhang; Zhicheng Lin; B Emmanuel Akinshola; George R. Uhl
Endocannabinoids and cannabinoid receptor genetics.
Progress in neurobiology 2002;66(5):307-44.
2002: Zhicheng Lin; George R. Uhl
Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism.
Molecular pharmacology 2002;61(4):885-91.
2002: Junichi Kitanaka; Nobue Kitanaka; Motohiko Takemura; Xiao-Bing Wang; Cambria M Hembree; Nancy L Goodman; George R. Uhl
Isolation and sequencing of a putative promoter region of the murine G protein beta 1 subunit (GNB1) gene.
DNA sequence : the journal of DNA sequencing and mapping 2002;13(1):39-45.
2002: Hirokazu Mizoguchi; Hsiang-En Wu; Minoru Narita; F S Hall; Ichiro Sora; George R. Uhl; Hiroshi Nagase; Leon F Tseng
Antagonistic property of buprenorphine for putative epsilon-opioid receptor-mediated G-protein activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse.
Neuroscience 2002;115(3):715-21.
2002: F Scott Hall; Xiao-Fei Li; Ichiro Sora; F Xu; M Caron; Klaus-Peter Lesch; Dennis L Murphy; George R. Uhl
Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.
Neuroscience 2002;115(1):153-61.
2002: George R. Uhl; F Scott Hall; Ichiro Sora
Cocaine, reward, movement and monoamine transporters.
Molecular psychiatry 2002;7(1):21-6.
2002: Eric T. Moolchan; Aleksandras Radzius; David H Epstein; George R. Uhl; David A Gorelick; Jean Lud Cadet; Jack E Henningfield
The Fagerstrom Test for Nicotine Dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?
Addictive behaviors 2002;27(1):101-13.
2001: Junichi Kitanaka; Xiao-Bing Wang; Nobue Kitanaka; C M Hembree; George R. Uhl
Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes.
DNA sequence : the journal of DNA sequencing and mapping 2001;12(5-6):345-54.
2001: George R. Uhl; Qingrong Liu; Donna Walther; Judith Hess; D Naiman
Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms.
American journal of human genetics 2001;69(6):1290-300.
2001: Dennis L Murphy; Qian Li; S Engel; Christine H Wichems; A Andrews; Klaus-Peter Lesch; George R. Uhl
Genetic perspectives on the serotonin transporter.
Brain research bulletin 2001;56(5):487-94.
2001: Antonio M Persico; E Mengual; Rainald Moessner; F S Hall; R S Revay; I Sora; J Arellano; J DeFelipe; J M Gimenez-Amaya; Monica Conciatori; R Marino; Alfonso Baldi; Simona Cabib; Tiziana Pascucci; George R. Uhl; Dennis L Murphy; Klaus-Peter Lesch; Flavio Keller; S F Hall
Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(17):6862-73.
2001: Ichiro Sora; Gregory I Elmer; M Funada; Jeanne O Pieper; Xiao-Fei Li; F Scott Hall; George R. Uhl
Mu opiate receptor gene dose effects on different morphine actions: evidence for differential in vivo mu receptor reserve.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(1):41-54.
2001: Ichiro Sora; F Scott Hall; Anne M Andrews; Masanari Itokawa; Xiao-Fei Li; H B Wei; Christine H Wichems; Klaus-Peter Lesch; Dennis L Murphy; George R. Uhl
Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5300-5.
2001: Cathy L Barr; C Xu; J Kroft; Y Feng; Karen Wigg; Gwyneth Zai; Rosemary Tannock; Russell Schachar; Molly Malone; Wendy Roberts; M M Nöthen; F Grünhage; D J Vandenbergh; George R. Uhl; GA Sunohara; Nicole King; James L Kennedy
Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder.
Biological psychiatry 2001;49(4):333-9.
2001: F Scott Hall; Ichiro Sora; George R. Uhl
Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice.
Psychopharmacology 2001;154(1):43-9.
2000: George R. Uhl; S Li; N Takahashi; K Itokawa; Zhicheng Lin; M Hazama; Ichiro Sora
The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2459-65.
2000: Zhicheng Lin; W Wang; George R. Uhl
Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains.
Molecular pharmacology 2000;58(6):1581-92.
2000: David J Vandenbergh; LA Rodriguez; E Hivert; Jocelyn Huang Schiller; G Villareal; E W Pugh; Herbert M Lachman; George R. Uhl
Long forms of the dopamine receptor (DRD4) gene VNTR are more prevalent in substance abusers: no interaction with functional alleles of the catechol-o-methyltransferase (COMT) gene.
American journal of medical genetics 2000;96(5):678-83.
2000: Christopher J LaBuda; I Sora; George R. Uhl; Perry N Fuchs
Stress-induced analgesia in mu-opioid receptor knockout mice reveals normal function of the delta-opioid receptor system.
Brain research 2000;869(1-2):1-5.
2000: Masanari Itokawa; Zhicheng Lin; Ning-Sheng Cai; C Wu; S Kitayama; Jia Bei Wang; George R. Uhl
Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions.
Molecular pharmacology 2000;57(6):1093-103.
2000: HB Deng; Y Yu; Y Pak; B F O'Dowd; S R George; C K Surratt; George R. Uhl; Jia Bei Wang
Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.
Biochemistry 2000;39(18):5492-9.
2000: David J Vandenbergh; Miles D Thompson; Edwin H Cook; E Bendahhou; T Nguyen; M D Krasowski; D Zarrabian; David E Comings; E M Sellers; R F Tyndale; Susan R George; Brian F O'Dowd; George R. Uhl
Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations.
Molecular psychiatry 2000;5(3):283-92.
2000: Zhicheng Lin; M Itokawa; George R. Uhl
Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):715-28.
2000: Yoshiaki Hosohata; Todd W Vanderah; TH Burkey; Michael H Ossipov; CJ Kovelowski; I Sora; George R. Uhl; X Zhang; Kenner C Rice; William R Roeske; Victor J Hruby; Henry I Yamamura; Josephine Lai; Frank Porreca
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
European journal of pharmacology 2000;388(3):241-8.
2000: C Qiu; I Sora; Ke Ren; George R. Uhl; Ronald Dubner
Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice.
European journal of pharmacology 2000;387(2):163-9.
1999: David M Donovan; LL Miner; M P Perry; RS Revay; Lawrence G Sharpe; Serge Przedborski; V Kostic; Rex Philpot; Cheryl L Kirstein; Richard B Rothman; Charles W Schindler; George R. Uhl
Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression.
Brain research. Molecular brain research 1999;73(1-2):37-49.
1999: K Itokawa; Ichiro Sora; Charles W Schindler; Masanari Itokawa; N Takahashi; George R. Uhl
Heterozygous VMAT2 knockout mice display prolonged QT intervals: possible contributions to sudden death.
Brain research. Molecular brain research 1999;71(2):354-7.
1999: Zhicheng Lin; W Wang; Theresa A Kopajtic; RS Revay; George R. Uhl
Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition.
Molecular pharmacology 1999;56(2):434-47.
1999: M Garzón; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter.
The Journal of comparative neurology 1999;410(2):197-210.
1999: George R. Uhl; Ichiro Sora; Zaijie Jim Wang
The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7752-5.
1999: PN Fuchs; C Roza; I Sora; George R. Uhl; Srinivasa N Raja
Characterization of mechanical withdrawal responses and effects of mu-, delta- and kappa-opioid agonists in normal and mu-opioid receptor knockout mice.
Brain research 1999;821(2):480-6.
1999: Ichiro Sora; Xiao-Fei Li; M Funada; S Kinsey; George R. Uhl
Visceral chemical nociception in mice lacking mu-opioid receptors: effects of morphine, SNC80 and U-50,488.
European journal of pharmacology 1999;366(2-3):R3-5.
1999: Hirokazu Mizoguchi; Minoru Narita; D E Oji; C Suganuma; Hiroshi Nagase; Ichiro Sora; George R. Uhl; E Y Cheng; Leon F Tseng
The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice.
Neuroscience 1999;94(1):203-7.
1999: Minoru Narita; Hirokazu Mizoguchi; M Narita; Ichiro Sora; George R. Uhl; Leon F Tseng
Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice.
British journal of pharmacology 1999;126(2):451-6.
1999: George R. Uhl
Molecular genetics of substance abuse vulnerability: a current approach.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;20(1):3-9.
1998: Tadashi Kusama; K Hatama; M Sakurai; Yasuo Kizawa; George R. Uhl; H Murakami
Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.
Neuroscience letters 1998;255(1):17-20.
1998: Shigeo Kitayama; Chieko Mitsuhata; S Davis; Jia Bei Wang; T Sato; Katsuya Morita; George R. Uhl; Toshihiro Dohi
MPP+ toxicity and plasma membrane dopamine transporter: study using cell lines expressing the wild-type and mutant rat dopamine transporters.
Biochimica et biophysica acta 1998;1404(3):305-13.
1998: Nobue Kitanaka; Ichiro Sora; S Kinsey; Z Zeng; George R. Uhl
No heroin or morphine 6beta-glucuronide analgesia in mu-opioid receptor knockout mice.
European journal of pharmacology 1998;355(1):R1-3.
1998: Ichiro Sora; Christine H Wichems; N Takahashi; Xiao-Fei Li; Z Zeng; RS Revay; Klaus-Peter Lesch; Dennis L Murphy; George R. Uhl
Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7699-704.
1998: Chieko Mitsuhata; Shigeo Kitayama; Katsuya Morita; D Vandenbergh; George R. Uhl; Toshihiro Dohi
Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine.
Brain research. Molecular brain research 1998;56(1-2):84-8.
1998: George R. Uhl
Hypothesis: the role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease.
Annals of neurology 1998;43(5):555-60.
1998: Richard B Rothman; M L Silverthorn; John R Glowa; Dorota Matecka; Kenner C Rice; Frank carroll; John S Partilla; George R. Uhl; David J Vandenbergh; Christina M Dersch
Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate.
Synapse (New York, N.Y.) 1998;28(4):322-38.
1998: A M Persico; Stephen G Reich; Jack E Henningfield; Michael J Kuhar; George R. Uhl
Parkinsonian patients report blunted subjective effects of methylphenidate.
Experimental and clinical psychopharmacology 1998;6(1):54-63.
1998: A M Persico; Charles W Schindler; S C Davis; E Ambrosio; George R. Uhl
Medial prefrontal cortical injections of c-fos antisense oligonucleotides transiently lower c-Fos protein and mimic amphetamine withdrawal behaviours.
Neuroscience 1998;82(4):1115-29.
1998: George R. Uhl; Zhicheng Lin; T Metzger; Dalit E Dar
Dopamine transporter mutants, small molecules, and approaches to cocaine antagonist/dopamine transporter disinhibitor development.
Methods in enzymology 1998;296():456-65.
1998: X B Wang; George R. Uhl
Subtracted differential display: genes with amphetamine-altered expression patterns include calcineurin.
Brain research. Molecular brain research 1998;53(1-2):344-7.
1998: Roxanne A Vaughan; Robin Huff; George R. Uhl; Michael J Kuhar
Phosphorylation of dopamine transporters and rapid adaptation to cocaine.
Advances in pharmacology (San Diego, Calif.) 1998;42():1042-5.
1998: George R. Uhl; David J Vandenbergh; LA Rodriguez; LL Miner; N Takahashi
Dopaminergic genes and substance abuse.
Advances in pharmacology (San Diego, Calif.) 1998;42():1024-32.
1998: Michael J Kuhar; R Vaughan; George R. Uhl; C Cerruti; R Revay; Curt R Freed; M Nirenburg; V Pickel
Localization of dopamine transporter protein by microscopic histochemistry.
Advances in pharmacology (San Diego, Calif.) 1998;42():168-70.
1997: Charles E Spivak; Carol L Beglan; B K Seidleck; Laura D Hirshbein; C J Blaschak; George R. Uhl; Christopher K Surratt
Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.
Molecular pharmacology 1997;52(6):983-92.
1997: H Wang; A Moriwaki; Jia Bei Wang; George R. Uhl; Virginia M Pickel
Ultrastructural immunocytochemical localization of mu-opioid receptors in dendritic targets of dopaminergic terminals in the rat caudate-putamen nucleus.
Neuroscience 1997;81(3):757-71.
1997: Y Yu; L Zhang; X Yin; H Sun; George R. Uhl; Jia Bei Wang
Mu opioid receptor phosphorylation, desensitization, and ligand efficacy.
The Journal of biological chemistry 1997;272(46):28869-74.
1997: N Takahashi; George R. Uhl
Murine vesicular monoamine transporter 2: molecular cloning and genomic structure.
Brain research. Molecular brain research 1997;49(1-2):7-14.
1997: MJ Nirenberg; June Chan; A Pohorille; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6899-907.
1997: N Takahashi; LL Miner; Ichiro Sora; H Ujike; RS Revay; V Kostic; Vernice Jackson-Lewis; Serge Przedborski; George R. Uhl
VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9938-43.
1997: David J Vandenbergh; Alan B Zonderman; Jia Bei Wang; George R. Uhl; Paul T Costa
No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants.
Molecular psychiatry 1997;2(5):417-9.
1997: X B Wang; M Funada; Y Imai; RS Revay; H Ujike; David J Vandenbergh; George R. Uhl
rGbeta1: a psychostimulant-regulated gene essential for establishing cocaine sensitization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(15):5993-6000.
1997: David J Vandenbergh; LA Rodriguez; I T Miller; George R. Uhl; Herbert M Lachman
High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers.
American journal of medical genetics 1997;74(4):439-42.
1997: MJ Nirenberg; June Chan; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(14):5255-62.
1997: Roxanne A Vaughan; Robin Huff; George R. Uhl; Michael J Kuhar
Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes.
The Journal of biological chemistry 1997;272(24):15541-6.
1997: MJ Nirenberg; June Chan; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4037-44.
1997: Ichiro Sora; M Funada; George R. Uhl
The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia.
European journal of pharmacology 1997;324(2-3):R1-2.
1997: George R. Uhl; L H Gold; N Risch
Genetic analyses of complex behavioral disorders.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2785-6.
1997: FG Kaddis; Edward D Clarkson; M J Weber; D J Vandenbergh; D M Donovan; J Mallet; P Horellou; George R. Uhl; Curt R Freed
Intrastriatal grafting of Cos cells stably expressing human aromatic L-amino acid decarboxylase: neurochemical effects.
Journal of neurochemistry 1997;68(4):1520-6.
1997: Adena L Svingos; A Moriwaki; Jia Bei Wang; George R. Uhl; Virginia M Pickel
mu-Opioid receptors are localized to extrasynaptic plasma membranes of GABAergic neurons and their targets in the rat nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(7):2585-94.
1997: Ichiro Sora; N Takahashi; M Funada; H Ujike; RS Revay; David M Donovan; LL Miner; George R. Uhl
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1544-9.
1997: Robin Huff; Roxanne A Vaughan; Michael J Kuhar; George R. Uhl
Phorbol esters increase dopamine transporter phosphorylation and decrease transport Vmax.
Journal of neurochemistry 1997;68(1):225-32.
1996: Elisabeth J Van Bockstaele; E E Colago; A Moriwaki; George R. Uhl
Mu-opioid receptor is located on the plasma membrane of dendrites that receive asymmetric synapses from axon terminals containing leucine-enkephalin in the rat nucleus locus coeruleus.
The Journal of comparative neurology 1996;376(1):65-74.
1996: H Wang; A Moriwaki; Jia Bei Wang; George R. Uhl; Virginia M Pickel
Ultrastructural immunocytochemical localization of mu opioid receptors and Leu5-enkephalin in the patch compartment of the rat caudate-putamen nucleus.
The Journal of comparative neurology 1996;375(4):659-74.
1996: A Moriwaki; Jia Bei Wang; Adena L Svingos; Elisabeth J Van Bockstaele; P Cheng; Virginia M Pickel; George R. Uhl
mu Opiate receptor immunoreactivity in rat central nervous system.
Neurochemical research 1996;21(11):1315-31.
1996: Shigeo Kitayama; Katsuya Morita; Toshihiro Dohi; Jia Bei Wang; S C Davis; George R. Uhl
Dissection of dopamine and cocaine binding sites on the rat dopamine transporter expressed in COS cells.
Annals of the New York Academy of Sciences 1996;801():388-93.
1996: A M Persico; G Bird; F H Gabbay; George R. Uhl
D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers.
Biological psychiatry 1996;40(8):776-84.
1996: A M Persico; George R. Uhl
Transcription factors: potential roles in drug-induced neuroplasticity.
Reviews in the neurosciences 1996;7(4):233-75.
1996: PY Cheng; A Moriwaki; Jia Bei Wang; George R. Uhl; Virginia M Pickel
Ultrastructural localization of mu-opioid receptors in the superficial layers of the rat cervical spinal cord: extrasynaptic localization and proximity to Leu5-enkephalin.
Brain research 1996;731(1-2):141-54.
1996: Elisabeth J Van Bockstaele; E E Colago; P Cheng; A Moriwaki; George R. Uhl; Virginia M Pickel
Ultrastructural evidence for prominent distribution of the mu-opioid receptor at extrasynaptic sites on noradrenergic dendrites in the rat nucleus locus coeruleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(16):5037-48.
1996: George R. Uhl; David J Vandenbergh; LL Miner
Knockout mice and dirty drugs. Drug addiction.
Current biology : CB 1996;6(8):935-6.
1996: Adena L Svingos; A Moriwaki; Jia Bei Wang; George R. Uhl; Virginia M Pickel
Ultrastructural immunocytochemical localization of mu-opioid receptors in rat nucleus accumbens: extrasynaptic plasmalemmal distribution and association with Leu5-enkephalin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(13):4162-73.
1996: L Zhang; Y Yu; S Mackin; F F Weight; George R. Uhl; Jia Bei Wang
Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters.
The Journal of biological chemistry 1996;271(19):11449-54.
1996: Eric O Johnson; Marianne B M van den Bree; George R. Uhl; Roy W Pickens
Indicators of genetic and environmental influences in drug abusing individuals.
Drug and alcohol dependence 1996;41(1):17-23.
1996: K Inoue; Kohji Sato; Masaya Tohyama; Shoichi Shimada; George R. Uhl
Widespread brain distribution of mRNA encoding the orphan neurotransmitter transporter v7-3.
Brain research. Molecular brain research 1996;37(1-2):217-23.
1996: David M Donovan; LL Miner; L Sharpe; H J Cho; M Takemura; Ellen M Unterwald; F Nyberg; M J Kreek; George R. Uhl
Transgenic mice: preproenkephalin and the mu opiate receptor.
Annals of the New York Academy of Sciences 1996;780():19-28.
1996: MJ Nirenberg; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(2):436-47.
1996: George R. Uhl
Commentary: three approaches to drug abuse genetics.
NIDA research monograph 1996;159():123-8.
1995: A M Persico; Z W Wang; D W Black; N C Andreasen; George R. Uhl; R R Crowe
Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders.
American journal of medical genetics 1995;60(6):563-5.
1995: Joel Gelernter; D Vandenbergh; S D Kruger; David L Pauls; Roger Kurlan; Andrew J Pakstis; Kenneth K Kidd; George R. Uhl
The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome.
Genomics 1995;30(3):459-63.
1995: Tadashi Kusama; M Sakurai; Yasuo Kizawa; George R. Uhl; H Murakami
GABA rho1 receptor: inhibition by protein kinase C activators.
European journal of pharmacology 1995;291(3):431-4.
1995: LL Miner; J Drago; P M Chamberlain; D Donovan; George R. Uhl
Retained cocaine conditioned place preference in D1 receptor deficient mice.
Neuroreport 1995;6(17):2314-6.
1995: Ellen M Unterwald; J M Rubenfeld; Y Imai; Jia Bei Wang; George R. Uhl; Mary Jeanne Kreek
Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels.
Brain research. Molecular brain research 1995;33(2):351-5.
1995: Richard B Rothman; Heng Xu; Jia Bei Wang; John S Partilla; H Kayakiri; Kenner C Rice; George R. Uhl
Ligand selectivity of cloned human and rat opioid mu receptors.
Synapse (New York, N.Y.) 1995;21(1):60-4.
1995: Curt R Freed; RS Revay; Roxanne A Vaughan; E Kriek; S Grant; George R. Uhl; Michael J Kuhar
Dopamine transporter immunoreactivity in rat brain.
The Journal of comparative neurology 1995;359(2):340-9.
1995: Richard B Rothman; M L Silverthorn; Michael H Baumann; Carl B Goodman; Jean Lud Cadet; Dorota Matecka; Kenner C Rice; Frank carroll; Jia Bei Wang; George R. Uhl
Studies of the biogenic amine transporters. VI. Characterization of a novel cocaine binding site, identified with [125I]RTI-55, in membranes prepared from whole rat brain minus caudate.
The Journal of pharmacology and experimental therapeutics 1995;274(1):385-95.
1995: Michael Schäfer; Y Imai; George R. Uhl; Christoph Stein
Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia.
European journal of pharmacology 1995;279(2-3):165-9.
1995: David M Donovan; D J Vandenbergh; M P Perry; G S Bird; R Ingersoll; E Nanthakumar; George R. Uhl
Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures.
Brain research. Molecular brain research 1995;30(2):327-35.
1995: Jia Bei Wang; A Moriwaki; George R. Uhl
Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression.
Journal of neurochemistry 1995;64(3):1416-9.
1995: A M Persico; Charles W Schindler; Robert Zaczek; M T Brannock; George R. Uhl
Brain transcription factor gene expression, neurotransmitter levels, and novelty response behaviors: alterations during rat amphetamine withdrawal and following chronic injection stress.
Synapse (New York, N.Y.) 1995;19(3):212-27.
1995: A M Persico; Z W Wang; D W Black; N C Andreasen; George R. Uhl; R R Crowe
Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders.
The American journal of psychiatry 1995;152(1):134-6.
1995: A Patel; J M Rochelle; J M Jones; Janos Sumegi; George R. Uhl; Michael F Seldin; Miriam H Meisler; P Gregor
Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3.
Genomics 1995;25(1):314-7.
1994: G Crosby; John J A Marota; T Goto; George R. Uhl
Subarachnoid morphine reduces stimulation-induced but not basal expression of preproenkephalin in rat spinal cord.
Anesthesiology 1994;81(5):1270-6.
1994: P Gregor; S M Gaston; X Yang; J P O'Regan; D R Rosen; Rudolph E Tanzi; D Patterson; Jonathan L Haines; H Robert Horvitz; George R. Uhl
Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21.
Human genetics 1994;94(5):565-70.
1994: George R. Uhl; P S Johnson
Neurotransmitter transporters: three important gene families for neuronal function.
The Journal of experimental biology 1994;196():229-36.
1994: Jia Bei Wang; P S Johnson; J M Wu; W F Wang; George R. Uhl
Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras.
The Journal of biological chemistry 1994;269(42):25966-9.
1994: Charles W Schindler; A M Persico; George R. Uhl; Steven R Goldberg
Behavioral assessment of high-dose amphetamine withdrawal: importance of training and testing conditions.
Pharmacology, biochemistry, and behavior 1994;49(1):41-6.
1994: Christopher K Surratt; P S Johnson; A Moriwaki; B K Seidleck; C J Blaschak; Jia Bei Wang; George R. Uhl
-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.
The Journal of biological chemistry 1994;269(32):20548-53.
1994: Shigeo Kitayama; Toshihiro Dohi; George R. Uhl
Phorbol esters alter functions of the expressed dopamine transporter.
European journal of pharmacology 1994;268(2):115-9.
1994: Jia Bei Wang; P S Johnson; Y Imai; A M Persico; B A Ozenberger; C M Eppler; George R. Uhl
cDNA cloning of an orphan opiate receptor gene family member and its splice variant.
FEBS letters 1994;348(1):75-9.
1994: T Kusama; Jia Bei Wang; C E Spivak; George R. Uhl
Mutagenesis of the GABA rho 1 receptor alters agonist affinity and channel gating.
Neuroreport 1994;5(10):1209-12.
1994: A M Gonzalez; George R. Uhl
'Choline/orphan V8-2-1/creatine transporter' mRNA is expressed in nervous, renal and gastrointestinal systems.
Brain research. Molecular brain research 1994;23(3):266-70.
1994: George R. Uhl; D Walther; Deborah C Mash; B Faucheux; France Javoy-Agid
Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons.
Annals of neurology 1994;35(4):494-8.
1994: C Cerruti; N S Pilotte; George R. Uhl; Michael J Kuhar
Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration.
Brain research. Molecular brain research 1994;22(1-4):132-8.
1994: V Blanchard; Rita Raisman-Vozari; Sheela Vyas; Patrick P Michel; France Javoy-Agid; George R. Uhl; Yves Agid
Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon.
Brain research. Molecular brain research 1994;22(1-4):29-38.
1994: A M Gonzalez; D Walther; Angel Pazos; George R. Uhl
Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile.
Brain research. Molecular brain research 1994;22(1-4):219-26.
1994: George R. Uhl; S Childers; Gavril W Pasternak
An opiate-receptor gene family reunion.
Trends in neurosciences 1994;17(3):89-93.
1994: Amy C Lossie; D J Vandenbergh; George R. Uhl; Sally A Camper
Localization of the dopamine transporter gene, Dat1, on mouse chromosome 13.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(2):117-8.
1994: Jia Bei Wang; P S Johnson; A M Persico; A L Hawkins; Constance A Griffin; George R. Uhl
Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment.
FEBS letters 1994;338(2):217-22.
1994: P S Johnson; Jia Bei Wang; W F Wang; George R. Uhl
Expressed mu opiate receptor couples to adenylate cyclase and phosphatidyl inositol turnover.
Neuroreport 1994;5(4):507-9.
1994: George R. Uhl
Association strategies in substance abuse.
EXS 1994;71():133-41.
1993: C M Eppler; J D Hulmes; Jia Bei Wang; B Johnson; M Corbett; D R Luthin; George R. Uhl; Joel Linden
Purification and partial amino acid sequence of a mu opioid receptor from rat brain.
The Journal of biological chemistry 1993;268(35):26447-51.
1993: Jia Bei Wang; Y Imai; C M Eppler; P Gregor; C E Spivak; George R. Uhl
mu opiate receptor: cDNA cloning and expression.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10230-4.
1993: Ted M Dawson; Joseph P Steiner; Valina Dawson; J L Dinerman; George R. Uhl; Solomon H Snyder
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9808-12.
1993: A M Persico; Charles W Schindler; B F O'Hara; M T Brannock; George R. Uhl
Brain transcription factor expression: effects of acute and chronic amphetamine and injection stress.
Brain research. Molecular brain research 1993;20(1-2):91-100.
1993: P Gregor; B F O'Hara; X Yang; George R. Uhl
Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.
Neuroreport 1993;4(12):1343-6.
1993: S Kitayama; Jia Bei Wang; George R. Uhl
Dopamine transporter mutants selectively enhance MPP+ transport.
Synapse (New York, N.Y.) 1993;15(1):58-62.
1993: Christopher K Surratt; Jia Bei Wang; S Yuhasz; Mario Amzel; H Moo Kwon; J S Handler; George R. Uhl
Sodium- and chloride-dependent transporters in brain, kidney, and gut: lessons from complementary DNA cloning and structure-function studies.
Current opinion in nephrology and hypertension 1993;2(5):744-60.
1993: A M Persico; David J Vandenbergh; S S Smith; George R. Uhl
Dopamine transporter gene polymorphisms are not associated with polysubstance abuse.
Biological psychiatry 1993;34(4):265-7.
1993: M Fujita; Shoichi Shimada; Tsunehiko Nishimura; George R. Uhl; Masaya Tohyama
Ontogeny of dopamine transporter mRNA expression in the rat brain.
Brain research. Molecular brain research 1993;19(3):222-6.
1993: A Patel; George R. Uhl; Michael J Kuhar
Species differences in dopamine transporters: postmortem changes and glycosylation differences.
Journal of neurochemistry 1993;61(2):496-500.
1993: B F O'Hara; S S Smith; G Bird; A M Persico; B K Suarez; Garry R Cutting; George R. Uhl
Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers.
Human heredity 1993;43(4):209-18.
1993: S S Smith; joseph newman; A Evans; Roy W Pickens; J Wydeven; George R. Uhl; David B Newlin
Comorbid psychopathy is not associated with increased D2 dopamine receptor TaqI A or B gene marker frequencies in incarcerated substance abusers.
Biological psychiatry 1993;33(11-12):845-8.
1993: Valina Dawson; Ted M Dawson; D A Bartley; George R. Uhl; Solomon H Snyder
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(6):2651-61.
1993: T Kusama; C E Spivak; P Whiting; Valina Dawson; J C Schaeffer; George R. Uhl
Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells.
British journal of pharmacology 1993;109(1):200-6.
1993: Valina Dawson; Ted M Dawson; George R. Uhl; Solomon H Snyder
Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3256-9.
1993: Roxanne A Vaughan; George R. Uhl; Michael J Kuhar
Recognition of dopamine transporters by antipeptide antibodies.
Molecular and cellular neurosciences 1993;4(2):209-15.
1993: C Cerruti; D M Walther; Michael J Kuhar; George R. Uhl
Dopamine transporter mRNA expression is intense in rat midbrain neurons and modest outside midbrain.
Brain research. Molecular brain research 1993;18(1-2):181-6.
1993: P Gregor; Roger H Reeves; Ethylin Jabs; X Yang; W Dackowski; J M Rochelle; R H Brown; Jonathan L Haines; B F O'Hara; George R. Uhl
Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):3053-7.
1993: T Kusama; T L Wang; William B Guggino; Garry R Cutting; George R. Uhl
GABA rho 2 receptor pharmacological profile: GABA recognition site similarities to rho 1.
European journal of pharmacology 1993;245(1):83-4.
1993: Christopher K Surratt; A M Persico; X D Yang; S R Edgar; G S Bird; A L Hawkins; Constance A Griffin; X Li; Ethylin Jabs; George R. Uhl
A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs.
FEBS letters 1993;318(3):325-30.
1993: George R. Uhl; K Blum; E Noble; S Smith
Substance abuse vulnerability and D2 receptor genes.
Trends in neurosciences 1993;16(3):83-8.
1993: A M Persico; B F O'Hara; S Farmer; R Gysin; S D Flanagan; George R. Uhl
Dopamine D2 receptor gene Taq I 'A' locus map including 'A4' variant: relevance for alcoholism and drug abuse.
Drug and alcohol dependence 1993;31(3):229-34.
1993: P Gregor; A Patel; S Shimada; C L Lin; J M Rochelle; S Kitayama; Michael F Seldin; George R. Uhl
Murine serotonin transporter: sequence and localization to chromosome 11.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(5):283-4.
1993: D Walther; M Takemura; George R. Uhl
Fos family member changes in nucleus caudalis neurons after primary afferent stimulation: enhancement of fos B and c-fos.
Brain research. Molecular brain research 1993;17(1-2):155-9.
1993: George R. Uhl; S Kitayama
A cloned dopamine transporter. Potential insights into Parkinson's disease pathogenesis.
Advances in neurology 1993;60():321-4.
1993: A M Persico; Charles W Schindler; M T Brannock; A M Gonzalez; Christopher K Surratt; George R. Uhl
Dopaminergic gene expression during amphetamine withdrawal.
Neuroreport 1993;4(1):41-4.
1992: David J Vandenbergh; A M Persico; A L Hawkins; Constance A Griffin; X Li; Ethylin Jabs; George R. Uhl
Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR.
Genomics 1992;14(4):1104-6.
1992: George R. Uhl; S Kitayama; P Gregor; E Nanthakumar; A Persico; S Shimada
Neurotransmitter transporter family cDNAs in a rat midbrain library: 'orphan transporters' suggest sizable structural variations.
Brain research. Molecular brain research 1992;16(3-4):353-9.
1992: P Gregor; X Yang; I Mano; M Takemura; Vivian I Teichberg; George R. Uhl
Organization and expression of the gene encoding chick kainate binding protein, a member of the glutamate receptor family.
Brain research. Molecular brain research 1992;16(3-4):179-86.
1992: George R. Uhl; P R Hartig
Transporter explosion: update on uptake.
Trends in pharmacological sciences 1992;13(12):421-5.
1992: G M Durand; P Gregor; Xin Zheng; Michael V L Bennett; George R. Uhl; R Suzanne Zukin
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9359-63.
1992: David J Vandenbergh; A M Persico; George R. Uhl
A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs.
Brain research. Molecular brain research 1992;15(1-2):161-6.
1992: S S Smith; B F O'Hara; A M Persico; D A Gorelick; David B Newlin; David Vlahov; L Solomon; Roy W Pickens; George R. Uhl
Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers.
Archives of general psychiatry 1992;49(9):723-7.
1992: S Kitayama; S Shimada; Heng Xu; L Markham; David M Donovan; George R. Uhl
Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7782-5.
1992: John J A Marota; G Crosby; George R. Uhl
Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain.
Anesthesiology 1992;77(2):365-71.
1992: S Kitayama; S Shimada; George R. Uhl
Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA.
Annals of neurology 1992;32(1):109-11.
1992: Edward G Stopa; George R. Uhl; B F O'Hara; R L Chorsky; J C King; E D Bird; H Wolfe
Somatostatin-gene expression in the postmortem adult and fetal human brain.
Peptide research 1992;5(4):201-5.
1992: George R. Uhl
Neurotransmitter transporters (plus): a promising new gene family.
Trends in neurosciences 1992;15(7):265-8.
1992: S Shimada; S Kitayama; D Walther; George R. Uhl
Dopamine transporter mRNA: dense expression in ventral midbrain neurons.
Brain research. Molecular brain research 1992;13(4):359-62.
1992: M Takemura; David M Donovan; George R. Uhl
Primary afferent stimulation acts through a 193 base pair promoter region to upregulate preproenkephalin expression in dorsal horn of transgenic mice.
Brain research. Molecular brain research 1992;13(3):207-12.
1992: Garry R Cutting; S Curristin; Huda Y Zoghbi; B O'Hara; Michael F Seldin; George R. Uhl
Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.
Genomics 1992;12(4):801-6.
1992: S Shimada; Garry R Cutting; George R. Uhl
gamma-Aminobutyric acid A or C receptor? gamma-Aminobutyric acid rho 1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive gamma-aminobutyric acid responses in Xenopus oocytes.
Molecular pharmacology 1992;41(4):683-7.
1992: David M Donovan; M Takemura; B F O'Hara; M T Brannock; George R. Uhl
Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2345-9.
1992: J W Boja; L Markham; A Patel; George R. Uhl; Michael J Kuhar
Expression of a single dopamine transporter cDNA can confer two cocaine binding sites.
Neuroreport 1992;3(3):247-8.
1992: George R. Uhl; A M Persico; S S Smith
Current excitement with D2 dopamine receptor gene alleles in substance abuse.
Archives of general psychiatry 1992;49(2):157-60.
1992: George R. Uhl
Neurotransmitter and drug receptor genes.
NIDA research monograph 1992;126():14-22.
1992: George R. Uhl
Elucidating neurotensin receptor cDNAs and their distribution.
Annals of the New York Academy of Sciences 1992;668():101-8.
1991: S Shimada; S Kitayama; C L Lin; A Patel; E Nanthakumar; P Gregor; Michael J Kuhar; George R. Uhl
Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.
Science (New York, N.Y.) 1991;254(5031):576-8.
1991: George R. Uhl; D Walther; T Nishimori; M G Buzzi; M A Moskowitz
Jun B, c-jun, jun D and c-fos mRNAs in nucleus caudalis neurons: rapid selective enhancement by afferent stimulation.
Brain research. Molecular brain research 1991;11(2):133-41.
1991: Garry R Cutting; L Lu; B F O'Hara; L M Kasch; C Montrose-Rafizadeh; David M Donovan; S Shimada; S E Antonarakis; William B Guggino; George R. Uhl
Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2673-7.
1991: J C Schaeffer; C L Lin; S Kitayama; George R. Uhl
Ligand autoradiographic receptor screening. II. Expression of receptor cDNA in transfected COS cells grown on polyester disks and its recovery.
Brain research. Molecular brain research 1991;9(3):271-6.
1991: S Shimada; C Spivak; George R. Uhl
Endothelin receptor: a profoundly desensitizing receptor expressed in Xenopus oocytes.
European journal of pharmacology 1991;193(1):123-5.
1991: George R. Uhl; B O'Hara; S Shimada; Robert Zaczek; J DiGiorgianni; T Nishimori
Dopamine transporter: expression in Xenopus oocytes.
Brain research. Molecular brain research 1991;9(1-2):23-9.
1990: T Nishimori; M G Buzzi; E H Chudler; C E Poletti; M A Moskowitz; George R. Uhl
Preproenkephalin upregulation in nucleus caudalis: high and low intensity afferent stimulation differentially modulate early and late responses.
The Journal of comparative neurology 1990;302(4):1002-18.
1990: A Jayaraman; T Nishimori; P Dobner; George R. Uhl
Cholecystokinin and neurotensin mRNAs are differentially expressed in subnuclei of the ventral tegmental area.
The Journal of comparative neurology 1990;296(2):291-302.
1990: Marcus Rattray; S L Lautar; George R. Uhl
Ligand autoradiographic receptor screening: receptor cDNA expression in replicas of transfected COS cells.
Brain research. Molecular brain research 1990;7(3):249-59.
1990: George R. Uhl; T Nishimori
Neuropeptide gene expression and neural activity: assessing a working hypothesis in nucleus caudalis and dorsal horn neurons expressing preproenkephalin and preprodynorphin.
Cellular and molecular neurobiology 1990;10(1):73-98.
1990: George R. Uhl
Parkinson's disease: neurotransmitter and neurotoxin receptors and their genes.
European neurology 1990;30 Suppl 1():21-30.
1990: George R. Uhl; D Appleby; T Nishimori; M G Buzzi; M A Moskowitz
Synaptic regulation of the enkephalin gene and transcription factors in vivo: possible roles in drug abuse.
NIDA research monograph 1990;105():123-9.
1989: Marcus Rattray; S L Lautar; George R. Uhl
A new method of screening receptor cDNAs: influence of plasmid competition on receptor expression.
Biochemical Society transactions 1989;17(6):1068-9.
1989: T Nishimori; M G Buzzi; M A Moskowitz; George R. Uhl
Preproenkephalin mRNA expression in nucleus caudalis neurons is enhanced by trigeminal stimulation.
Brain research. Molecular brain research 1989;6(2-3):203-10.
1989: M D Linnik; Damianos E Sakas; George R. Uhl; M A Moskowitz
Subarachnoid blood and headache: altered trigeminal tachykinin gene expression.
Annals of neurology 1989;25(2):179-84.
1989: George R. Uhl
In situ hybridization: quantitation using radiolabeled hybridization probes.
Methods in enzymology 1989;168():741-52.
1989: S A Rivkees; M R Chaar; Daniel F Hanley; M Maxwell; S M Reppert; George R. Uhl
Localization and regulation of vasopressin mRNA in human neurons.
Synapse (New York, N.Y.) 1989;3(3):246-54.
1988: George R. Uhl; B Navia; J Douglas
Differential expression of preproenkephalin and preprodynorphin mRNAs in striatal neurons: high levels of preproenkephalin expression depend on cerebral cortical afferents.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(12):4755-64.
1988: M M Voigt; George R. Uhl
Preprocholecystokinin mRNA in rat brain: regional expression includes thalamus.
Brain research 1988;464(3):247-53.
1988: George R. Uhl; J P Ryan; J P Schwartz
Morphine alters preproenkephalin gene expression.
Brain research 1988;459(2):391-7.
1988: T Nishimori; Michael A Moskowitz; George R. Uhl
Opioid peptide gene expression in rat trigeminal nucleus caudalis neurons: normal distribution and effects of trigeminal deafferentation.
The Journal of comparative neurology 1988;274(1):142-50.
1988: Steven M Reppert; George R. Uhl
The vasopressin gene is expressed prior to regulation in the supraoptic nuclei of fetal rats.
Brain research 1988;456(2):392-6.
1987: S M Reppert; George R. Uhl
Vasopressin messenger ribonucleic acid in supraoptic and suprachiasmatic nuclei: appearance and circadian regulation during development.
Endocrinology 1987;120(6):2483-7.
1986: George R. Uhl; C A Sasek
Somatostatin mRNA: regional variation in hybridization densities in individual neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(11):3258-64.
1986: George R. Uhl; G O Hackney; M Torchia; V Stranov; W W Tourtellotte; Peter J Whitehouse; V Tran; S Strittmatter
Parkinson's disease: nigral receptor changes support peptidergic role in nigrostriatal modulation.
Annals of neurology 1986;20(2):194-203.
1986: George R. Uhl; S M Reppert
Suprachiasmatic nucleus vasopressin messenger RNA: circadian variation in normal and Brattleboro rats.
Science (New York, N.Y.) 1986;232(4748):390-3.
1986: M Flint Beal; George R. Uhl; M F Mazurek; Neil W Kowall; J B Martin
Somatostatin: alterations in the central nervous system in neurological diseases.
Research publications - Association for Research in Nervous and Mental Disease 1986;64():215-57.
1985: George R. Uhl; V Tran; Solomon H Snyder; J B Martin
Somatostatin receptors: distribution in rat central nervous system and human frontal cortex.
The Journal of comparative neurology 1985;240(3):288-304.
1985: George R. Uhl; J C Hedreen; Donald L Price
Parkinson's disease: loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions.
Neurology 1985;35(8):1215-8.
1985: George R. Uhl; H H Zingg; J F Habener
Vasopressin mRNA in situ hybridization: localization and regulation studied with oligonucleotide cDNA probes in normal and Brattleboro rat hypothalamus.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(16):5555-9.
1985: George R. Uhl; J A Javitch; Solomon H Snyder
Normal MPTP binding in parkinsonian substantial nigra: evidence for extraneuronal toxin conversion in human brain.
Lancet 1985;1(8435):956-7.
1984: George R. Uhl; Peter J Whitehouse; Donald L Price; W W Tourtelotte; Michael J Kuhar
Parkinson's disease: depletion of substantia nigra neurotensin receptors.
Brain research 1984;308(1):186-90.
1984: J A Javitch; George R. Uhl; Solomon H Snyder
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: characterization and localization of receptor binding sites in rat and human brain.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4591-5.
1984: J C Hedreen; George R. Uhl; S J Bacon; D M Fambrough; Donald L Price
Acetylcholinesterase-immunoreactive axonal network in monkey visual cortex.
The Journal of comparative neurology 1984;226(2):246-54.
1984: V T Tran; George R. Uhl; D C Perry; D C Manning; W W Vale; M H Perrin; J E Rivier; J B Martin; Solomon H Snyder
Autoradiographic localization of somatostatin receptors in rat brain.
European journal of pharmacology 1984;101(3-4):307-9.
1984: George R. Uhl; Michael J Kuhar
Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra.
Nature 1984;309(5966):350-2.
1983: George R. Uhl; D C Hilt; J C Hedreen; Peter J Whitehouse; Donald L Price
Pick's disease (lobar sclerosis): depletion of neurons in the nucleus basalis of Meynert.
Neurology 1983;33(11):1470-3.
1982: George R. Uhl
Distribution of neurotensin and its receptor in the central nervous system.
Annals of the New York Academy of Sciences 1982;400():132-49.
1981: George R. Uhl; C R Martinez; B R Brooks
Spinal seizures following intravenous contrast in a patients with a cord AVM.
Annals of neurology 1981;10(6):580-1.
1981: George R. Uhl; Solomon H Snyder
Neurotensin.
Advances in biochemical psychopharmacology 1981;28():87-106.
1980: J H Neale; J L Barker; George R. Uhl; Solomon H Snyder
Immunohistochemical localization of an opiate peptide.
JAMA : the journal of the American Medical Association 1980;243(21):2217.
1979: George R. Uhl; R R Goodman; Solomon H Snyder
Neurotensin-containing cell bodies, fibers and nerve terminals in the brain stem of the rat: immunohistochemical mapping.
Brain research 1979;167(1):77-91.
1979: George R. Uhl; R R Goodman; Michael J Kuhar; S R Childers; Solomon H Snyder
Immunohistochemical mapping of enkephalin containing cell bodies, fibers and nerve terminals in the brain stem of the rat.
Brain research 1979;166(1):75-94.
1979: F M Corrêa; Robert B Innis; George R. Uhl; Solomon H Snyder
Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(3):1489-93.
1979: George R. Uhl; Solomon H Snyder
Neurotensin: a neuronal pathway projecting from amygdala through stria terminalis.
Brain research 1979;161(3):522-6.
1979: Robert B Innis; F M Corrêa; George R. Uhl; B Schneider; Solomon H Snyder
Cholecystokinin octapeptide-like immunoreactivity: histochemical localization in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(1):521-5.
1979: Michael J Kuhar; George R. Uhl
Histochemical localization of opiate receptors and the enkephalins.
Advances in biochemical psychopharmacology 1979;20():53-68.
1978: J H Neale; J L Barker; George R. Uhl; Solomon H Snyder
Enkephalin-containing neurons visualized in spinal cord cell cultures.
Science (New York, N.Y.) 1978;201(4354):467-9.
1978: W S Young; George R. Uhl; Michael J Kuhar
Iontophoresis of neurotensin in the area of the locus coeruleus.
Brain research 1978;150(2):431-5.
1978: George R. Uhl; Michael J Kuhar; S H Synder
Enkephalin-containing pathway: amygdaloid efferents in the stria terminalis.
Brain research 1978;149(1):223-8.
1978: Solomon H Snyder; George R. Uhl; R Miller
Brain peptides secreted by gut tumors.
The New England journal of medicine 1978;298(22):1259-60.
1978: George R. Uhl; R R Goodman; Michael J Kuhar; Solomon H Snyder
Enkephalin and neurotensin: immunohistochemical localization and identification of an amygdalofugal pathway.
Advances in biochemical psychopharmacology 1978;18():71-87.
1977: George R. Uhl; Michael J Kuhar; Solomon H Snyder
Neurotensin: immunohistochemical localization in rat central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(9):4059-63.
1977: George R. Uhl; J P Bennett; Solomon H Snyder
Neurotensin, a central nervous system peptide: apparent receptor binding in brain membranes.
Brain research 1977;130(2):299-313.
1977: R Simantov; Michael J Kuhar; George R. Uhl; Solomon H Snyder
Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(5):2167-71.
1977: George R. Uhl; Solomon H Snyder
Neurotensin receptor binding, regional and subcellular distributions favor transmitter role.
European journal of pharmacology 1977;41(1):89-91.
1976: George R. Uhl; Solomon H Snyder
Regional and subcellular distributions of brain neurotensin.
Life sciences 1976;19(12):1827-32.