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Ralph Carmel

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Ralph Carmel
Diagnosis and management of clinical and subclinical cobalamin deficiencies: why controversies persist in the age of sensitive metabolic testing.
Ralph Carmel
Subclinical cobalamin deficiency.
Ralph Carmel
Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II.

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All Publications

2013: Ralph Carmel
Diagnosis and management of clinical and subclinical cobalamin deficiencies: why controversies persist in the age of sensitive metabolic testing.
Biochimie 2013;95(5):1047-55.
2012: Ralph Carmel
Subclinical cobalamin deficiency.
Current opinion in gastroenterology 2012;28(2):151-8.
2011: Ralph Carmel
Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II.
The American journal of clinical nutrition 2011;94(1):348S-358S.
2011: Ralph Carmel
Mandatory fortification of the food supply with cobalamin: an idea whose time has not yet come.
Journal of inherited metabolic disease 2011;34(1):67-73.
2010: Ralph Carmel; Rita Bellevue; Zvi Kelman
Low cobalamin levels associated with sickle cell disease: Contrasting origins and clinical meanings in two instructive patients.
American journal of hematology 2010;85(6):436-9.
2009: Ralph Carmel; James Parker; Zvi Kelman
Genomic mutations associated with mild and severe deficiencies of transcobalamin I (haptocorrin) that cause mildly and severely low serum cobalamin levels.
British journal of haematology 2009;147(3):386-91.
2008: Ralph Carmel
How I treat cobalamin (vitamin B12) deficiency.
Blood 2008;112(6):2214-21.
2008: Ralph Carmel
Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects.
Food and nutrition bulletin 2008;29(2 Suppl):S177-87.
2007: Ralph Carmel
The disappearance of cobalamin absorption testing: a critical diagnostic loss.
The Journal of nutrition 2007;137(11):2481-4.
2006: Ralph Carmel; Mona Sarrai
Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies.
Current hematology reports 2006;5(1):23-33.
2005: Xinke Chen; Angel F Remacha; M Pilar Sardà; Ralph Carmel
Influence of cobalamin deficiency compared with that of cobalamin absorption on serum holo-transcobalamin II.
The American journal of clinical nutrition 2005;81(1):110-4.
2004: Meekoo Dhar; Rita Bellevue; Shabneet Brar; Ralph Carmel
Mild hyperhomocysteinemia in adult patients with sickle cell disease: a common finding unrelated to folate and cobalamin status.
American journal of hematology 2004;76(2):114-20.
2003: Ralph Carmel
Mild transcobalamin I (haptocorrin) deficiency and low serum cobalamin concentrations.
Clinical chemistry 2003;49(8):1367-74.
2003: Meekoo Dhar; Rita Bellevue; Ralph Carmel
Pernicious anemia with neuropsychiatric dysfunction in a patient with sickle cell anemia treated with folate supplementation.
The New England journal of medicine 2003;348(22):2204-7.
2003: Ralph Carmel; Stepan Melnyk; S Jill James
Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
Blood 2003;101(8):3302-8.
2002: Ralph Carmel; S Jill James
Alcohol abuse: an important cause of severe hyperhomocysteinemia.
Nutrition reviews 2002;60(7 Pt 1):215-21.
2002: Ralph Carmel; Padmaja V Mallidi; Simon Vinarskiy; Shabneet Brar; Zohreh Frouhar
Hyperhomocysteinemia and cobalamin deficiency in young Asian Indians in the United States.
American journal of hematology 2002;70(2):107-14.
2001: Ralph Carmel; H Vasireddy; I Aurangzeb; K George
High serum cobalamin levels in the clinical setting--clinical associations and holo-transcobalamin changes.
Clinical and laboratory haematology 2001;23(6):365-71.
2001: Ralph Carmel; Shabneet Brar; Z Frouhar
Plasma total transcobalamin I. Ethnic/racial patterns and comparison with lactoferrin.
American journal of clinical pathology 2001;116(4):576-80.
2001: J C Lin; N Borregaard; H A Liebman; Ralph Carmel
Deficiency of the specific granule proteins, R-binder/transcobalamin I and lactoferrin, in plasma and saliva: a new disorder.
American journal of medical genetics 2001;100(2):145-51.
2001: Ralph Carmel
Anemia and aging: an overview of clinical, diagnostic and biological issues.
Blood reviews 2001;15(1):9-18.
2001: Ralph Carmel; I Aurangzeb; D Qian
Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis.
The American journal of gastroenterology 2001;96(1):63-70.
2000: Ralph Carmel; Shabneet Brar; A Agrawal; P D Penha
Failure of assay to identify low cobalamin concentrations.
Clinical chemistry 2000;46(12):2017-8.
2000: H Cohen; W M Weinstein; Ralph Carmel
Heterogeneity of gastric histology and function in food cobalamin malabsorption: absence of atrophic gastritis and achlorhydria in some patients with severe malabsorption.
Gut 2000;47(5):638-45.
2000: Ralph Carmel
Current concepts in cobalamin deficiency.
Annual review of medicine 2000;51():357-75.
1999: Ralph Carmel; Ralph Green; D W Jacobsen; K Rasmussen; M Florea; Colleen Azen
Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities.
The American journal of clinical nutrition 1999;70(5):904-10.
1998: J M Howard; Colleen Azen; D W Jacobsen; Ralph Green; Ralph Carmel
Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels.
European journal of clinical nutrition 1998;52(8):582-7.
1997: Ralph Carmel
Cobalamin, the stomach, and aging.
The American journal of clinical nutrition 1997;66(4):750-9.
1996: Ralph Carmel; J M Howard; Ralph Green; D W Jacobsen; Colleen Azen
Hormone replacement therapy and cobalamin status in elderly women.
The American journal of clinical nutrition 1996;64(6):856-9.
1996: Ralph Carmel; Ralph Green; D W Jacobsen; G D Qian
Neutrophil nuclear segmentation in mild cobalamin deficiency: relation to metabolic tests of cobalamin status and observations on ethnic differences in neutrophil segmentation.
American journal of clinical pathology 1996;106(1):57-63.
1996: Ralph Carmel; K Cairo; W Bondareff; P S Gott; Jeffrey L Cummings; Victor W. Henderson
Spouses of demented patients with low cobalamin levels: a new risk group for cobalamin deficiency.
European journal of haematology 1996;57(1):62-7.
1996: Ralph Carmel
Prevalence of undiagnosed pernicious anemia in the elderly.
Archives of internal medicine 1996;156(10):1097-100.
1996: Ralph Carmel; K Rasmussen; D W Jacobsen; Ralph Green
Comparison of the deoxyuridine suppression test with serum levels of methylmalonic acid and homocysteine in mild cobalamin deficiency.
British journal of haematology 1996;93(2):311-8.
1995: Ralph Carmel
Malabsorption of food cobalamin.
Baillière's clinical haematology 1995;8(3):639-55.
1995: Ralph Carmel; P S Gott; CH Waters; K Cairo; Ralph Green; W Bondareff; Christopher M DeGiorgio; Jeffrey L Cummings; D W Jacobsen; G Buckwalter
The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities.
European journal of haematology 1995;54(4):245-53.
1994: Ralph Carmel
In vitro studies of gastric juice in patients with food-cobalamin malabsorption.
Digestive diseases and sciences 1994;39(12):2516-22.
1994: Ralph Carmel
Approach to a low vitamin B12 level.
JAMA : the journal of the American Medical Association 1994;272(16):1233.
1994: Ralph Carmel
Megaloblastic anemias.
Current opinion in hematology 1994;1(2):107-12.
1994: Ralph Carmel; G I Perez-Perez; Martin Blaser
Helicobacter pylori infection and food-cobalamin malabsorption.
Digestive diseases and sciences 1994;39(2):309-14.
1993: S Saxena; J M Weiner; A Rabinowitz; J Fridey; I A Shulman; Ralph Carmel
Transfusion practice in medical patients.
Archives of internal medicine 1993;153(22):2575-80.
1993: Ralph Carmel; A P Rabinowitz; A Mazumder
Metabolic evidence of cobalamin deficiency in bone marrow cells harvested for transplantation from donors given nitrous oxide.
European journal of haematology 1993;50(4):228-33.
1992: Ralph Carmel; B S Skikne
Serum transferrin receptor in the megaloblastic anemia of cobalamin deficiency.
European journal of haematology 1992;49(5):246-50.
1992: Ralph Carmel
Reassessment of the relative prevalences of antibodies to gastric parietal cell and to intrinsic factor in patients with pernicious anaemia: influence of patient age and race.
Clinical and experimental immunology 1992;89(1):74-7.
1992: Ralph Carmel; R D MacPhee
Erythropoietin levels in cobalamin deficiency: comparison of anemic and non-anemic, subtly deficient patients.
European journal of haematology 1992;48(3):159-62.
1992: Ralph Carmel
Reversal by cobalamin therapy of minimal defects in the deoxyuridine suppression test in patients without anemia: further evidence for a subtle metabolic cobalamin deficiency.
The Journal of laboratory and clinical medicine 1992;119(3):240-4.
1991: Tse-Ling Fong; C P Dooley; M Dehesa; H Cohen; Ralph Carmel; P L Fitzgibbons; G I Perez-Perez; Martin Blaser
Helicobacter pylori infection in pernicious anemia: a prospective controlled study.
Gastroenterology 1991;100(2):328-32.
1990: D S Karnaze; Ralph Carmel
Neurologic and evoked potential abnormalities in subtle cobalamin deficiency states, including deficiency without anemia and with normal absorption of free cobalamin.
Archives of neurology 1990;47(9):1008-12.
1990: Ralph Carmel
Subtle and atypical cobalamin deficiency states.
American journal of hematology 1990;34(2):108-14.
1990: A Del Corral; Ralph Carmel
Transfer of cobalamin from the cobalamin-binding protein of egg yolk to R binder of human saliva and gastric juice.
Gastroenterology 1990;98(6):1460-6.
1990: Ralph Carmel; S M Neely; R B Francis
Human umbilical vein endothelial cells secrete transcobalamin II.
Blood 1990;75(1):251-4.
1989: Ralph Carmel; Ira A Shulman
Blood transfusion in medically treatable chronic anemia. Pernicious anemia as a model for transfusion overuse.
Archives of pathology & laboratory medicine 1989;113(9):995-7.
1988: Ralph Carmel
Treatment of severe pernicious anemia: no association with sudden death.
The American journal of clinical nutrition 1988;48(6):1443-4.
1988: Ralph Carmel; R M Sinow; M E Siegel; I M Samloff
Food cobalamin malabsorption occurs frequently in patients with unexplained low serum cobalamin levels.
Archives of internal medicine 1988;148(8):1715-9.
1988: Ralph Carmel
Pernicious anemia. The expected findings of very low serum cobalamin levels, anemia, and macrocytosis are often lacking.
Archives of internal medicine 1988;148(8):1712-4.
1988: Ralph Carmel; K H Lau; D J Baylink; Sunita Saxena; F R Singer
Cobalamin and osteoblast-specific proteins.
The New England journal of medicine 1988;319(2):70-5.
1988: Ralph Carmel; D Watkins; S I Goodman; D S Rosenblatt
Hereditary defect of cobalamin metabolism (cblG mutation) presenting as a neurologic disorder in adulthood.
The New England journal of medicine 1988;318(26):1738-41.
1988: Ralph Carmel; M Linker-Israeli
Monoclonal antibodies to different sites on human transcobalamin II.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1988;188(1):77-81.
1988: Ralph Carmel; D S Karnaze; J M Weiner
Neurologic abnormalities in cobalamin deficiency are associated with higher cobalamin "analogue" values than are hematologic abnormalities.
The Journal of laboratory and clinical medicine 1988;111(1):57-62.
1987: R E Nimo; Ralph Carmel
Increased sensitivity of detection of the blocking (type I) anti-intrinsic factor antibody.
American journal of clinical pathology 1987;88(6):729-33.
1987: Ralph Carmel; C S Johnson; J M Weiner
Pernicious anemia in Latin Americans is not a disease of the elderly.
Archives of internal medicine 1987;147(11):1995-6.
1987: R M Sinow; C S Johnson; D S Karnaze; M E Siegel; Ralph Carmel
Unsuspected pernicious anemia in a patient with sickle cell disease receiving routine folate supplementation.
Archives of internal medicine 1987;147(10):1828-9.
1987: Ralph Carmel; R M Sinow; D S Karnaze
Atypical cobalamin deficiency. Subtle biochemical evidence of deficiency is commonly demonstrable in patients without megaloblastic anemia and is often associated with protein-bound cobalamin malabsorption.
The Journal of laboratory and clinical medicine 1987;109(4):454-63.
1987: D S Karnaze; Ralph Carmel
Low serum cobalamin levels in primary degenerative dementia. Do some patients harbor atypical cobalamin deficiency states?
Archives of internal medicine 1987;147(3):429-31.
1987: R L Burkes; H Cohen; M Krailo; R M Sinow; Ralph Carmel
Low serum cobalamin levels occur frequently in the acquired immune deficiency syndrome and related disorders.
European journal of haematology 1987;38(2):141-7.
1986: Ralph Carmel; D S Karnaze
Physician response to low serum cobalamin levels.
Archives of internal medicine 1986;146(6):1161-5.
1985: Ralph Carmel; D S Karnaze
The deoxyuridine suppression test identifies subtle cobalamin deficiency in patients without typical megaloblastic anemia.
JAMA : the journal of the American Medical Association 1985;253(9):1284-7.