FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Peter Carmeliet

Research Profile

Living Beings

Chemicals & Drugs

Physiology

Disorders

Anatomy

Co-author Network

Publications

TOP 3
Peter Carmeliet; Carmen Ruiz de Almodovar
VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration.
Stephanie Coulon; Peter Carmeliet; Christophe Casteleyn; Isabelle Colle; Femke Heindryckx; Bart Jonckx; Isabelle Leclercq; Vanessa Legry; Louis Libbrecht; Kim Olievier; Jean Marie Stassen; Christophe Van Steenkiste; Hans Van Vlierberghe; Anja Geerts
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.
Kathrin Arndt; Peter Carmeliet; Denis Corbeil; Tatyana Grinenko; Nicole Mende; Melanie Portz; Doreen Reichert; Tatsiana Ripich; Claudia Waskow
CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Peter Carmeliet (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Peter Carmeliet; Carmen Ruiz de Almodovar
VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration.
Cellular and molecular life sciences : CMLS 2013;70(10):1763-78.
2013: Stephanie Coulon; Peter Carmeliet; Christophe Casteleyn; Isabelle Colle; Femke Heindryckx; Bart Jonckx; Isabelle Leclercq; Vanessa Legry; Louis Libbrecht; Kim Olievier; Jean Marie Stassen; Christophe Van Steenkiste; Hans Van Vlierberghe; Anja Geerts
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.
Hepatology (Baltimore, Md.) 2013;57(5):1793-805.
2013: Kathrin Arndt; Peter Carmeliet; Denis Corbeil; Tatyana Grinenko; Nicole Mende; Melanie Portz; Doreen Reichert; Tatsiana Ripich; Claudia Waskow
CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5582-7.
2013: Diether Lambrechts; Heinz-Josef Lenz; Peter Carmeliet; Sanne de Haas; Stefan J Scherer
Markers of response for the antiangiogenic agent bevacizumab.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(9):1219-30.
2013: Tara L Walker; Ann Wierick; Peter Carmeliet; Denis Corbeil; Alex M Sykes; Ben Waldau; Gerd Kempermann
Prominin-1 allows prospective isolation of neural stem cells from the adult murine hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(7):3010-24.
2013: Vincent Jean Henry; Amandine Jullienne; Vincent Laudenbach; Maryline Lecointre; Carine Ali; Vincent Berezowski; Peter Carmeliet; Bruno J Gonzalez; Richard Macrez; Stéphane Marret; Denis Vivien; Philippe Leroux
High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate.
Neurobiology of disease 2013;50():201-8.
2013: Femke Heindryckx; Louis Libbrecht; Jean-Marie Stassen; Ellen Terrie; Joke Allemeersch; Peter Carmeliet; Christophe Casteleyn; Isabelle Colle; Stephanie Coulon; Anja Geerts; Hans Van Vlierberghe
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model.
Journal of hepatology 2013;58(2):319-28.
2013: Roel Quintens; Johannes Anthonius Romijn; Anica Schraenen; Peter Carmeliet; Veronica Costa; Katrien De Bock; Geoffroy De Faudeur; Mikaela Granvik; Diether Lambrechts; Stefan Lehnert; Katleen Lemaire; Henri Roger Lijnen; Pradeep Puthenveetil Abraham Mammen; Luca Scorrano; John Michael Shelton; Sarvjeet Singh; Lieven Thorrez; Leentje Van Lommel; Pieter Van Noten; Peter J Voshol; Irene Olga Cornelia Maria Vroegrijk; Frans Schuit
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance.
PloS one 2013;8(2):e56719.
2013: Brian W Wong; Anna Kuchnio; Ulrike Bruning; Peter Carmeliet
Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes.
Trends in biochemical sciences 2013;38(1):3-11.
2012: Katrin Martens; Annelies Peeters; Paul P Van Veldhoven; Astrid Bottelbergs; Peter Carmeliet; Marc Espeel; Frank Jacobs; Myriam Baes
Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone.
Molecular genetics and metabolism 2012;107(4):735-47.
2012: Ombretta Guardiola; Salvatore Iaconis; Peggy Lafuste; Giovanna L Liguori; Enza Lonardo; Gennaro Andolfi; Ann Bouché; Silvia Brunelli; Peter Carmeliet; Giulio Cossu; Katrien De Bock; Philippos Mourikis; Michael M Shen; Shahragim Tajbakhsh; Thierry Touvier; Gabriella Minchiotti
Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):E3231-40.
2012: Peter Carmeliet; Brian W Wong; Katrien De Bock
Treating diabetes by blocking a vascular growth factor.
Cell metabolism 2012;16(5):553-5.
2012: Nick van Gastel; Peter Carmeliet; Aernout Luttun; Frank P Luyten; Karen Moermans; Scott J Roberts; Jan Schrooten; Sophie Torrekens; Geert Carmeliet
Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells.
Stem cells (Dayton, Ohio) 2012;30(11):2460-71.
2012: Femke Heindryckx; Louis Libbrecht; Jean Marie Stassen; Eliene Bogaerts; Peter Carmeliet; Isabelle O Colle; Stephanie H Coulon; Hilde Devlies; Anja M Geerts; Hans R Van Vlierberghe
Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model.
European journal of gastroenterology & hepatology 2012;24(9):1020-32.
2012: An Verheyen; Peter Carmeliet; Anneleen Daniels; Joke Dhondt; Theo Meert; Rony Nuydens; Eve Peeraer; Isabel Pintelon; Koen Poesen; Jean-Pierre Timmermans; Diether Lambrechts
Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy.
Brain : a journal of neurology 2012;135(Pt 9):2629-41.
2012: Judit Kiss; Massimiliano Mazzone; Martin Mollenhauer; Thomas Niemietz; Praveen Radhakrishnan; Gunnar Steinert; Sarah R Walmsley; Jürgen Weitz; Moira K B Whyte; Peter Carmeliet; Johanna Dudda; Johanna Kirchberg; Martin Schneider
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1955-65.
2012: Rodrigo Leite de Oliveira; Annelies Peeters; Carmen Roncal; Evelyne Tack; Yukiji Takeda; Lorenzo Veschini; Kari Alitalo; Andrey Anisimov; Myriam Baes; Peter Carmeliet; Koen Debackere; Sofie Deschoemaeker; Daniela Dettori; Jan D'Hooge; Veronica Finisguerra; Anne-Theres Henze; Matthias Hofmann; Yannick Jönsson; Massimiliano Mazzone
Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity.
Cancer cell 2012;22(2):263-77.
2012: Maarten F Corsten; Menno de Winther; Marion J J Gijbels; Mark Hazebroek; Erik A L Biessen; Paolo Carai; Peter Carmeliet; Susan L M Coort; Sakari Kauppinen; Morten Lindow; Susanna Obad; Anna Papageorgiou; Blanche Schroen; Frank R M Stassen; Georg Summer; Rick E W van Leeuwen; Wouter Verhesen; Erwin Wijnands; Stephane Heymans
MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.
Circulation research 2012;111(4):415-25.
2012: Diether Lambrechts; Massimiliano Mazzone; Joke Reumers; Stefan J Scherer; Sabine Tejpar; Peter Carmeliet; Bart Claes; Sanne de Haas; Paul Delmar; Roland Devlieger; Chris Verslype; Hans Wildiers; Betül T Yesilyurt; Eric Van Cutsem
VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials.
The lancet oncology 2012;13(7):724-33.
2012: Sonja Bobic; Dominique M A Bullens; Ina Callebaut; Peter Carmeliet; Jan L Ceuppens; Vanessa De Vooght; Christophe Dooms; Valerie Hox; Bart Jonckx; Jean-Marie Saint-Remy; Sven Seys; Jean Marie Stassen; Stefan Vinckier; Peter W Hellings
Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma.
American journal of respiratory cell and molecular biology 2012;46(6):781-9.
2012: Bruno Detry; Charlotte Erpicum; Jean-Michel Foidart; Els Janssens; Frederic Kridelka; Françoise Lamaye; Vincent Lambert; Catherine Maillard; Lieve Moons; Sandra Ormenese; Jenny Paupert; Hélène Pendeville; Thibault Remacle; Ingrid Struman; Marc Thiry; Cédric Balsat; Silvia Blacher; Françoise Bruyère; Peter Carmeliet; Didier Cataldo; Agnès Noel
Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.
Blood 2012;119(21):5048-56.
2012: Anna-Pia Papageorgiou; Melissa Swinnen; Thierry VandenDriessche; Davy Vanhoutte; Wouter Verhesen; Dirk Westermann; Peter Carmeliet; Marinee Chuah; Bart de Vries; Jan D'hooge; Diana Lindner; Esther Lutgens; Stephane Heymans
Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells.
Cardiovascular research 2012;94(1):115-24.
2012: Kristoffer S Rohrberg; Birgit Guldhammer Skov; Morten Sørensen; René K Olesen; Helle Pappot; Per Pfeiffer; Ian Buysschaert; Peter Carmeliet; Ib J Christensen; Gunilla Høyer-Hansen; Morten Ladekarl; Ulrik Lassen
Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers.
Acta oncologica (Stockholm, Sweden) 2012;51(2):234-42.
2012: Aurélie Carlier; Geert Carmeliet; Peter Carmeliet; Liesbet Geris; Katie Bentley; Hans Van Oosterwyck
MOSAIC: a multiscale model of osteogenesis and sprouting angiogenesis with lateral inhibition of endothelial cells.
PLoS computational biology 2012;8(10):e1002724.
2012: Mieke Dewerchin; Peter Carmeliet
PlGF: a multitasking cytokine with disease-restricted activity.
Cold Spring Harbor perspectives in medicine 2012;2(8):.
2011: Annelies Peeters; Mark H Rider; Hiroshi Takemori; Sjoerd van den Berg; Ko Willems van Dijk; Antoine Van Kampen; Paul P Van Veldhoven; Emiel Ver Loren van Themaat; Peter Carmeliet; Peter Fraisl; Myriam Baes
Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.
The Journal of biological chemistry 2011;286(49):42162-79.
2011: Goedele Wallays; Zsuzsanna Callaerts-Vegh; Peter Carmeliet; Désiré Collen; Rudi D'Hooge; Florea Lupu; Lieve Moons; Dieter Nuyens; Robert Silasi-Mansat; Joris Souffreau; An Van Nuffelen; Mieke Dewerchin
Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2881-8.
2011: Erik Storkebaum; Miikka Vikkula; Annelies Quaegebeur; Peter Carmeliet
Cerebrovascular disorders: molecular insights and therapeutic opportunities.
Nature neuroscience 2011;14(11):1390-7.
2011: Benjamin Beck; Amélie Caauwe; Aurélie Candi; Peter Carmeliet; Sophie Dekoninck; Gregory Driessens; Benjamin Drogat; Steven Goossens; Jody J Haigh; Anna Kuchnio; Gaelle Lapouge; Sonja Loges; Guilhem Mascre; Panagiota A Sotiropoulou; Khalil Kass Youssef; Cédric Blanpain
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours.
Nature 2011;478(7369):399-403.
2011: Julie Adam; Dilair Baban; Peter Carmeliet; Mona El-Bahrawy; Roman Fischer; Norma Frizzell; Emine Hatipoglu; Benedikt M Kessler; Helen Lockstone; Patrick H Maxwell; Emma Nye; Linda O'Flaherty; Christopher W Pugh; Peter J Ratcliffe; Natasha Sahgal; Tomoyoshi Soga; Gordon W Stamp; Marcus Stevens; Nicola Ternette; Kathryn Wolhuter; Patrick J Pollard
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Cancer cell 2011;20(4):524-37.
2011: Michael Potente; Holger Gerhardt; Peter Carmeliet
Basic and therapeutic aspects of angiogenesis.
Cell 2011;146(6):873-87.
2011: Hu Huang; Rachel Parlier; Richard D Semba; Sara Van de Veire; Peter Carmeliet; Mansi Dalal; Stanley A Vinores
Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration.
Investigative ophthalmology & visual science 2011;52(10):7565-73.
2011: Erik Storkebaum; Peter Carmeliet
Paracrine control of vascular innervation in health and disease.
Acta physiologica (Oxford, England) 2011;203(1):61-86.
2011: Geert C van Almen; Wouter Verhesen; Fons K Verheyen; Yigal M Pinto; Blanche Schroen; Melissa Swinnen; Paolo Carai; Peter Carmeliet; Jack P M Cleutjens; Jan D'hooge; Stephane Heymans
Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy.
Journal of molecular and cellular cardiology 2011;51(3):318-28.
2011: Claire Meissirel; Yvette Michotte; Salvatore Oliviero; Wim Robberecht; Véronique Rogemond; Carmen Ruiz de Almodovar; Paul Salin; Dietmar Schmucker; Inmaculada Segura; Ilse Smolders; Nicole Thomasset; Ludo Van Den Bosch; Pieter Vanden Berghe; Stefan Vinckier; Denis Vivien; Thomas Voets; Alain Chédotal; Naura Chounlamountri; Cathy Coulon; Karel Dassonville; Maria De Mol; Pierre de Rossi; Bérangère Deléglise; Mieke Dewerchin; Jérôme Honnorat; Ellen Knevels; Ellen Loyens; Carine Ali; Kristof Anthonis; Peter Carmeliet
VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13782-7.
2011: Annelies Quaegebeur; Christian Lange; Peter Carmeliet
The neurovascular link in health and disease: molecular mechanisms and therapeutic implications.
Neuron 2011;71(3):406-24.
2011: Katrien De Bock; Massimiliano Mazzone; Peter Carmeliet
Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
Nature reviews. Clinical oncology 2011;8(7):393-404.
2011: Xabier L Aranguren; Manu Beerens; Peter Carmeliet; Mieke Dewerchin; Wouter Vandevelde; Aernout Luttun
Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis.
Biochemical and biophysical research communications 2011;410(1):121-6.
2011: Thomas Schmidt; Marc Tjwa; Peter Vandenberghe; Catherine M Verfaillie; Stefan Vinckier; Karolien Beel; Tim H Brümmendorf; Geert Carmeliet; Sandra Cauwenberghs; Richard E Clark; Jan Cools; Kim De Keersmaecker; Maria De Mol; Mieke Dewerchin; Sérgio Dias; Rita Fragoso; Peter Fraisl; Andreas Hochhaus; Tessa Holyoake; Bart Jonckx; Michael Karin; Behzad Kharabi Masouleh; Maria Kleppe; Sonja Loges; Christa Maes; Shahin Rafii; Thomas Schenk; Peter Carmeliet
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.
Cancer cell 2011;19(6):740-53.
2011: Carmen Ruiz de Almodovar; Inmaculada Segura; Geraldine Strasser; Marc Tessier-Lavigne; Stefan Vinckier; Leona Aerts; Kari Alitalo; Valerie Castellani; Frederic Charron; Alain Chedotal; Cathy Coulon; Nicolas Delattin; Pierre Fabre; Coralie Fouquet; Chengua Gu; Patrick C G Haddick; Jody Haigh; Ellen Knevels; Christian Lange; Won-Jong Oh; Peter Carmeliet
VEGF mediates commissural axon chemoattraction through its receptor Flk1.
Neuron 2011;70(5):966-78.
2011: Peter Carmeliet; Rakesh K Jain
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.
Nature reviews. Drug discovery 2011;10(6):417-27.
2011: Andrea Casazza; Xi Fu; Irja Johansson; Lorena Capparuccia; Fredrik Andersson; Alice Giustacchini; Mario Leonardo Squadrito; Mary Anna Venneri; Massimiliano Mazzone; Erik Larsson; Peter Carmeliet; Michele De Palma; Luigi Naldini; Luca Tamagnone; Charlotte Rolny
Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(4):741-9.
2011: Linda Chaballe; Pierre Close; Maxime Sempels; Stéphanie Delstanche; Julien Fanielle; Lieve Moons; Peter Carmeliet; Jean Schoenen; Alain Chariot; Rachelle Franzen
Involvement of placental growth factor in Wallerian degeneration.
Glia 2011;59(3):379-96.
2011: Soraya Labied; Silvia Blacher; Peter Carmeliet; Agnès Noël; Francis Frankenne; Jean-Michel Foidart; Carine Munaut
Transient reduction of placental angiogenesis in PAI-1-deficient mice.
Physiological genomics 2011;43(4):188-98.
2011: Michella Ghassibe-Sabbagh; Laurence Desmyter; Tobias Langenberg; Filip Claes; Odile Boute; Bénédicte Bayet; Philippe Pellerin; Karlien Hermans; Liesbeth Backx; Maria Adela Mansilla; Sandra Imoehl; Stefanie Nowak; Kerstin U Ludwig; Carlotta Baluardo; Melissa Ferrian; Peter Anthony Mossey; Markus Noethen; Mieke Dewerchin; Geneviève François; Nicole Revencu; Romain Vanwijck; Jacqueline Hecht; Elisabeth Mangold; Jeffrey Murray; Michele Rubini; Joris R Vermeesch; Hélène A Poirel; Peter Carmeliet; Miikka Vikkula
FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish.
American journal of human genetics 2011;88(2):150-61.
2011: Katrien De Bock; Sandra Cauwenberghs; Peter Carmeliet
Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications.
Current opinion in genetics & development 2011;21(1):73-9.
2011: Charlotte Rolny; Massimiliano Mazzone; Sònia Tugues; Damya Laoui; Irja Johansson; Cathy Coulon; Mario Leonardo Squadrito; Inmaculada Segura; Xiujuan Li; Ellen Knevels; Sandra Costa; Stefan Vinckier; Tom Dresselaer; Peter Åkerud; Maria De Mol; Henriikka Salomäki; Mia Phillipson; Sabine Wyns; Erik Larsson; Ian Buysschaert; Johan Botling; Uwe Himmelreich; Jo A Van Ginderachter; Michele De Palma; Mieke Dewerchin; Lena Claesson-Welsh; Peter Carmeliet
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Cancer cell 2011;19(1):31-44.
2010: Cathy Coulon; Maria Georgiadou; Carmen Roncal; Katrien De Bock; Tobias Langenberg; Peter Carmeliet
From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(12):2331-6.
2010: Andreas Blana; Sven Kaese; Lisa Fortmüller; Sandra Laakmann; Dierk Damke; Kelly van Bragt; Jens Eckstein; Ilaria Piccini; Uwe Kirchhefer; Stanley Nattel; Günter Breithardt; Peter Carmeliet; Edward Carmeliet; Ulrich Schotten; Sander Verheule; Paulus Kirchhof; Larissa Fabritz
Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(12):1862-9.
2010: Murtaza Tambuwala; Eoin P Cummins; Colin R Lenihan; Judit Kiss; Markus Stauch; Carsten C Scholz; Peter Fraisl; Felix Lasitschka; Martin Mollenhauer; Sean P Saunders; Patrick H Maxwell; Peter Carmeliet; Padraic G Fallon; Martin Schneider; Cormac T Taylor
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.
Gastroenterology 2010;139(6):2093-101.
2010: Annelies Quaegebeur; Inmaculada Segura; Peter Carmeliet
Pericytes: blood-brain barrier safeguards against neurodegeneration?
Neuron 2010;68(3):321-3.
2010: Christophe E Pierreux; S Cordi; Anne-Christine Hick; Younes Achouri; Carmen Ruiz de Almodovar; Pierre-Paul Prévot; Pierre J Courtoy; Peter Carmeliet; Frédéric P Lemaigre
Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.
Developmental biology 2010;347(1):216-27.
2010: Maija Bry; Riikka Kivelä; Tanja Holopainen; Andrey Anisimov; Tuomas Tammela; Jarkko Soronen; Johanna Silvola; Antti Saraste; Michael Jeltsch; Petra Korpisalo; Peter Carmeliet; Karl B Lemström; Masabumi Shibuya; Seppo Ylä-Herttuala; Leena Alhonen; Eero Mervaala; Leif C Andersson; Juhani Knuuti; Kari Alitalo
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.
Circulation 2010;122(17):1725-33.
2010: An Vanden Bosch; Tim Raemaekers; Sarah Denayer; Sophie Torrekens; Nico Smets; Karen Moermans; Mieke Dewerchin; Peter Carmeliet; Geert Carmeliet
NuSAP is essential for chromatin-induced spindle formation during early embryogenesis.
Journal of cell science 2010;123(Pt 19):3244-55.
2010: Ilse Geudens; Robert Herpers; Karlien Hermans; Inmaculada Segura; Carmen Ruiz de Almodovar; Jeroen Bussmann; Frank De Smet; Wouter Vandevelde; Benjamin M Hogan; Arndt Siekmann; Filip Claes; John C Moore; Anna Silvia Pistocchi; Sonja Loges; Massimiliano Mazzone; Giovanni Mariggi; Françoise Bruyère; Franco Cotelli; Dontscho Kerjaschki; Agnes Noël; Jean-Michel Foidart; Holger Gerhardt; Annelii Ny; Tobias Langenberg; Nathan D Lawson; Henricus J Duckers; Stefan Schulte-Merker; Peter Carmeliet; Mieke Dewerchin
Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(9):1695-702.
2010: Lieve Coenegrachts; Christa Maes; Sophie Torrekens; Riet Van Looveren; Massimiliano Mazzone; Theresa A Guise; Roger Bouillon; Jean Marie Stassen; Peter Carmeliet; Geert Carmeliet
Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation.
Cancer research 2010;70(16):6537-47.
2010: Barbara Costa; Daniela Dettori; Annalisa Lorenzato; Chiara Bardella; Nadia Coltella; Cosimo Martino; Cristina Cammarata; Peter Carmeliet; Martina Olivero; Maria Flavia Di Renzo
Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(8):2680-8.
2010: Erik Storkebaum; Carmen Ruiz de Almodovar; Merlijn Meens; Serena Zacchigna; Massimiliano Mazzone; Greet Vanhoutte; Stefan Vinckier; Katarzyna Miskiewicz; Koen Poesen; Diether Lambrechts; Ger M J Janssen; Gregorio E Fazzi; Patrik Verstreken; Jody Haigh; Paul M Schiffers; Hermann Rohrer; Annemie Van der Linden; Jo De Mey; Peter Carmeliet
Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery.
Circulation 2010;122(3):273-81.
2010: Larissa Fabritz; Dierk Damke; Markus Emmerich; Susann G Kaufmann; Kathrin Theis; Andreas Blana; Lisa Fortmüller; Sandra Laakmann; Sven Hermann; Elena Aleynichenko; Johannes Steinfurt; Daniela Volkery; Burkhard Riemann; Uwe Kirchhefer; Michael R Franz; Günter Breithardt; Edward Carmeliet; Michael Schäfers; Sebastian K G Maier; Peter Carmeliet; Paulus Kirchhof
Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.
Cardiovascular research 2010;87(1):60-72.
2010: Anthony A Lanahan; Karlien Hermans; Filip Claes; Joanna S Kerley-Hamilton; Zhen W Zhuang; Frank J Giordano; Peter Carmeliet; Michael Simons
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.
Developmental cell 2010;18(5):713-24.
2010: Pipsa Saharinen; Hanna Helotera; Juho J Miettinen; Camilla Norrmen; Gabriela D'Amico; Michael Jeltsch; Tobias Langenberg; Wouter Vandevelde; Annelii Ny; Mieke Dewerchin; Peter Carmeliet; Kari Alitalo
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.
Genes & development 2010;24(9):875-80.
2010: Carmen Roncal; Ian Buysschaert; Norbert Gerdes; Maria Georgiadou; Olga Ovchinnikova; Christian Fischer; Jean Marie Stassen; Lieve Moons; Désiré Collen; Katrien De Bock; Göran K Hansson; Peter Carmeliet
Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions.
Cardiovascular research 2010;86(1):29-36.
2010: Sonja Loges; Thomas Schmidt; Marc Tjwa; Katie van Geyte; Dirk Lievens; Esther Lutgens; Davy Vanhoutte; Delphine Borgel; Stephane Plaisance; Marc Hoylaerts; Aernout Luttun; Mieke Dewerchin; Bart Jonckx; Peter Carmeliet
Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.
Blood 2010;115(11):2264-73.
2010: Martin Schneider; Katie Van Geyte; Peter Fraisl; Judit Kiss; Julián Aragonés; Massimiliano Mazzone; Heimo Mairbäurl; Katrien De Bock; Nam Ho Jeoung; Martin Mollenhauer; Maria Georgiadou; Tammie Bishop; Carmen Roncal; Andrew Sutherland; Benedicte Jordan; Bernard Gallez; Jürgen Weitz; Robert A Harris; Patrick Maxwell; Myriam Baes; Peter Ratcliffe; Peter Carmeliet
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.
Gastroenterology 2010;138(3):1143-54.e1-2.
2010: Christa Maes; Steven Goossens; Sonia Bartunkova; Benjamin Drogat; Lieve Coenegrachts; Ingrid Stockmans; Karen Moermans; Omar Nyabi; Katharina Haigh; Michael Naessens; Lieven Haenebalcke; Jan P Tuckermann; Marc Tjwa; Peter Carmeliet; Vice Mandic; Jean-Pierre David; Axel Behrens; Andras Nagy; Geert Carmeliet; Jody J Haigh
Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones.
The EMBO journal 2010;29(2):424-41.
2010: Annelies Quaegebeur; Peter Carmeliet
Oxygen sensing: a common crossroad in cancer and neurodegeneration.
Current topics in microbiology and immunology 2010;345():71-103.
2009: An Van den Bergh; Peter Vangheluwe; Annelies Vanderper; Peter Carmeliet; Frank Wuytack; Stefan Janssens; Willem Flameng; Paul Holvoet; Paul Herijgers
Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve.
European journal of heart failure 2009;11(12):1118-25.
2009: Diether Lambrechts; K Poesen; R Fernández-Santiago; A Al-Chalabi; R Del Bo; P W J Van Vught; S Khan; S L Marklund; A Brockington; I van Marion; J Anneser; C Shaw; A C Ludolph; N P Leigh; G P Comi; T Gasser; P J Shaw; K E Morrison; P M Andersen; L H Van den Berg; V Thijs; T Siddique; Wim Robberecht; Peter Carmeliet
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype.
Journal of medical genetics 2009;46(12):840-6.
2009: Inmaculada Segura; Frederik De Smet; Philipp J Hohensinner; Carmen Ruiz de Almodovar; Peter Carmeliet
The neurovascular link in health and disease: an update.
Trends in molecular medicine 2009;15(10):439-51.
2009: Sonja Loges; Thomas Schmidt; Peter Carmeliet
"Antimyeloangiogenic" therapy for cancer by inhibiting PlGF.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3648-53.
2009: Katrien De Bock; Frank De Smet; Rodrigo Leite De Oliveira; Kristof Anthonis; Peter Carmeliet
Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells.
Journal of molecular medicine (Berlin, Germany) 2009;87(6):561-9.
2009: Frank De Smet; Inmaculada Segura; Katrien De Bock; Philipp J Hohensinner; Peter Carmeliet
Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(5):639-49.
2009: Carmen Ruiz de Almodovar; Diether Lambrechts; Massimiliano Mazzone; Peter Carmeliet
Role and therapeutic potential of VEGF in the nervous system.
Physiological reviews 2009;89(2):607-48.
2009: Massimiliano Mazzone; Daniela Dettori; Rodrigo Leite de Oliveira; Sonja Loges; Thomas Schmidt; Bart Jonckx; Ya-Min Tian; Anthony A Lanahan; Patrick Pollard; Carmen Ruiz de Almodovar; Frank De Smet; Stefan Vinckier; Julián Aragonés; Koen Debackere; Aernout Luttun; Sabine Wyns; Benedicte Jordan; Alberto Pisacane; Bernard Gallez; Maria Grazia Lampugnani; Elisabetta Dejana; Michael Simons; Peter Ratcliffe; Patrick Maxwell; Peter Carmeliet
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Cell 2009;136(5):839-51.
2009: Sonja Loges; Massimiliano Mazzone; Philipp Hohensinner; Peter Carmeliet
Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited.
Cancer cell 2009;15(3):167-70.
2009: Serena Zacchigna; Hideyasu Oh; Michaela Wilsch-Bräuninger; Ewa Missol-Kolka; József Jászai; Sandra Jansen; Naoyuki Tanimoto; Felix Tonagel; Mathias W Seeliger; Wieland B Huttner; Denis Corbeil; Mieke Dewerchin; Stefan Vinckier; Lieve Moons; Peter Carmeliet
Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2297-308.
2009: Johanna E Lähteenvuo; Markku T Lähteenvuo; Antti Kivelä; Carolina Rosenlew; Annelie Falkevall; Joakim Klar; Tommi Heikura; Tuomas T Rissanen; Elisa Vähäkangas; Petra Korpisalo; Berndt Enholm; Peter Carmeliet; Kari Alitalo; Ulf Eriksson; Seppo Ylä-Herttuala
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.
Circulation 2009;119(6):845-56.
2009: Peter Fraisl; Massimiliano Mazzone; Thomas Schmidt; Peter Carmeliet
Regulation of angiogenesis by oxygen and metabolism.
Developmental cell 2009;16(2):167-79.
2009: Peter Fraisl; Julián Aragonés; Peter Carmeliet
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease.
Nature reviews. Drug discovery 2009;8(2):139-52.
2009: Mark Schellings; Davy Vanhoutte; Melissa Swinnen; Jack P M Cleutjens; Jacques Debets; Rick E W van Leeuwen; Jan d'Hooge; Frans Van de Werf; Peter Carmeliet; Yigal M Pinto; E Helene Sage; Stephane Heymans
Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction.
The Journal of experimental medicine 2009;206(1):113-23.
2009: Julián Aragonés; Peter Fraisl; Myriam Baes; Peter Carmeliet
Oxygen sensors at the crossroad of metabolism.
Cell metabolism 2009;9(1):11-22.
2009: Andrei Tintu; Ellen Rouwet; Stefan Verlohren; Joep Brinkmann; Shakil Ahmad; Fatima Crispi; Marc van Bilsen; Peter Carmeliet; Anne Cathrine Staff; Marc Tjwa; Irene Cetin; Eduard Gratacos; Edgar Hernandez-Andrade; Leo Hofstra; Michael Jacobs; Wouter H Lamers; Ingo Morano; Erdal Safak; Asif Ahmed; Ferdinand le Noble
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences.
PloS one 2009;4(4):e5155.
2008: Christian Fischer; Massimiliano Mazzone; Bart Jonckx; Peter Carmeliet
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
Nature reviews. Cancer 2008;8(12):942-56.
2008: Marc Tjwa; Stefan Janssens; Peter Carmeliet
Plasmin therapy enhances mobilization of HPCs after G-CSF.
Blood 2008;112(10):4048-50.
2008: Jianxin Fu; Holger Gerhardt; Karlien Hermans; Lacramioara Ivanciu; Tongzhong Ju; Xiaowei Liu; Florea Lupu; J Michael McDaniel; Samuel McGee; Annelii Ny; Emma Nye; Maria I Ramirez; Robert Silasi-Mansat; Baoyun Xia; Peter Carmeliet; Richard D Cummings; Lijun Xia
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
The Journal of clinical investigation 2008;118(11):3725-37.
2008: Moises Freitas-Andrade; Peter Carmeliet; Danica Stanimirovic; Maria Moreno
VEGFR-2-mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytes.
Journal of neurochemistry 2008;107(3):756-67.
2008: Kiichiro Yano; Yoshiaki Okada; Guido Beldi; Shu-Ching Shih; Natalya Bodyak; Hitomi Okada; Peter M Kang; William Luscinskas; Simon C Robson; Peter Carmeliet; S Ananth Karumanchi; William C Aird
Elevated levels of placental growth factor represent an adaptive host response in sepsis.
The Journal of experimental medicine 2008;205(11):2623-31.
2008: Koen Poesen; Diether Lambrechts; Philip Van Damme; Joke Dhondt; Florian Bender; Nicolas Frank; Elke Bogaert; Bart Claes; Line Heylen; An Verheyen; Katrien Raes; Marc Tjwa; Ulf Eriksson; Masabumi Shibuya; Rony Nuydens; Ludo Van Den Bosch; Theo F Meert; Rudi D'Hooge; Michael Sendtner; Wim Robberecht; Peter Carmeliet
Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(42):10451-9.
2008: Masahiro Murakami; Loc T Nguyen; Zhen W Zhuang; Zhen W Zhang; Karen L Moodie; Peter Carmeliet; Radu V Stan; Michael Simons
The FGF system has a key role in regulating vascular integrity.
The Journal of clinical investigation 2008;118(10):3355-66.
2008: Esther Lutgens; M Tjwa; P Garcia de Frutos; E Wijnands; Linda Beckers; B Dahlbäck; M J A P Daemen; Peter Carmeliet; L Moons
Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis.
The Journal of pathology 2008;216(1):55-63.
2008: Xuri Li; Marc Tjwa; Inge Van Hove; Berndt Enholm; Elke Neven; Karri Paavonen; Michael Jeltsch; Toni Diez Juan; Richard E Sievers; Emmanuel Chorianopoulos; Hiromichi Wada; Maarten Vanwildemeersch; Agnes Noel; Jean-Michel Foidart; Matthew L Springer; Georges von Degenfeld; Mieke Dewerchin; Helen M Blau; Kari Alitalo; Ulf Eriksson; Peter Carmeliet; Lieve Moons
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(9):1614-20.
2008: Annelii Ny; Marta Koch; Wouter Vandevelde; Martin Schneider; Christian Fischer; Antonio Diez-juan; Elke Neven; Ilse Geudens; Sunit Maity; Lieve Moons; Stephane Plaisance; Diether Lambrechts; Peter Carmeliet; Mieke Dewerchin
Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles.
Blood 2008;112(5):1740-9.
2008: Berta Vidal; Antonio L Serrano; Marc Tjwa; Mònica Suelves; Esther Ardite; Roberta De Mori; Bernat Baeza-Raja; María Martínez de Lagrán; Peggy Lafuste; Vanessa Ruiz-Bonilla; Mercè Jardí; Romain Gherardi; Christo Christov; Mara Dierssen; Peter Carmeliet; Jay L Degen; Mieke Dewerchin; Pura Muñoz-Cánoves
Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway.
Genes & development 2008;22(13):1747-52.
2008: Massimiliano Mazzone; Peter Carmeliet
Drug discovery: a lifeline for suffocating tissues.
Nature 2008;453(7199):1194-5.
2008: Peter Carmeliet; Myriam Baes
Metabolism and therapeutic angiogenesis.
The New England journal of medicine 2008;358(23):2511-2.
2008: Michele D Binder; Holly S Cate; Anne L Prieto; Dennis Kemper; Helmut Butzkueven; Melissa M Gresle; Tania Cipriani; Vilija G Jokubaitis; Peter Carmeliet; Trevor J Kilpatrick
Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(20):5195-206.
2008: Charlotte Rolny; Lorena Capparuccia; Andrea Casazza; Massimiliano Mazzone; Antonella Vallario; Alessandro Cignetti; Enzo Medico; Peter Carmeliet; paolo comoglio; Luca Tamagnone
The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment.
The Journal of experimental medicine 2008;205(5):1155-71.
2008: Françoise Bruyère; Laurence Melen-Lamalle; Silvia Blacher; Guy Roland; Marc Thiry; Lieve Moons; Francis Frankenne; Peter Carmeliet; Kari Alitalo; Claude Libert; Jonathan P Sleeman; Jean-Michel Foidart; Agnès Noël
Modeling lymphangiogenesis in a three-dimensional culture system.
Nature methods 2008;5(5):431-7.
2008: Tammie Bishop; Denis Gallagher; Alberto Pascual; Craig A Lygate; Joseph P de Bono; Lynn G Nicholls; Patricia Ortega-Saenz; Henrik Oster; Bhathiya Wijeyekoon; Andrew I Sutherland; Alexandra Grosfeld; Julian Aragones; Martin Schneider; Katie van Geyte; Dania Teixeira; Antonio Diez-juan; Jose Lopez-Barneo; Keith M Channon; Patrick H Maxwell; Christopher W Pugh; Alun M Davies; Peter Carmeliet; Peter J Ratcliffe
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Molecular and cellular biology 2008;28(10):3386-400.
2008: Nynke van den Akker; Vincenza Caolo; Lambertus J Wisse; Patricia P W M Peters; Robert E Poelmann; Peter Carmeliet; Daniël G M Molin; Adriana C Gittenberger-De Groot
Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.
Cardiovascular research 2008;78(2):366-75.
2008: Marc Tjwa; Lola Bellido-Martin; Yuan Lin; Esther Lutgens; Stephane Plaisance; Françoise Bono; Nathalie Delesque-Touchard; Caroline Hervé; Rute Moura; An D Billiau; Cristina Aparicio; Marcel Levi; Mat Daemen; Mieke Dewerchin; Florea Lupu; Jef Arnout; Jean-Marc Herbert; Mark Waer; Pablo García de Frutos; Björn Dahlbäck; Peter Carmeliet; Marc F Hoylaerts; Lieve Moons
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
Blood 2008;111(8):4096-105.
2008: Philip Van Damme; Annelies Van Hoecke; Diether Lambrechts; Peter Vanacker; Elke Bogaert; John van Swieten; Peter Carmeliet; Ludo Van Den Bosch; Wim Robberecht
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.
The Journal of cell biology 2008;181(1):37-41.
2008: Olga Mikhaylova; Monika L Ignacak; Teresa J Barankiewicz; Svetlana V Harbaugh; Ying Yi; Patrick H Maxwell; Martin Schneider; Katie Van Geyte; Peter Carmeliet; Monica P Revelo; MA Wyder; Kenneth D Greis; Jaroslaw Meller; Maria F Czyzyk-Krzeska
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
Molecular and cellular biology 2008;28(8):2701-17.
2008: Rosemarijn Renckens; Joris J T H Roelofs; M E Stegenga; Sandrine Florquin; Marcel Levi; Peter Carmeliet; Cornelis Van't Veer; Tom van der Poll
Transgenic tissue-type plasminogen activator expression improves host defense during Klebsiella pneumonia.
Journal of thrombosis and haemostasis : JTH 2008;6(4):660-8.
2008: Peter Fraisl; Myriam Baes; Peter Carmeliet
Hungry for blood vessels: linking metabolism and angiogenesis.
Developmental cell 2008;14(3):313-4.
2008: Serena Zacchigna; Diether Lambrechts; Peter Carmeliet
Neurovascular signalling defects in neurodegeneration.
Nature reviews. Neuroscience 2008;9(3):169-81.
2008: Lizhen Li; Andrea Lundkvist; Daniel Andersson; Ulrika Wilhelmsson; Nobuo Nagai; Andrea C Pardo; Christina Nodin; Anders Ståhlberg; Karina Aprico; Kerstin Larsson; Takeshi Yabe; Lieve Moons; Andrew Fotheringham; Ioan Davies; Peter Carmeliet; Joan P Schwartz; Marcela Pekna; Kubista Mikael; Fredrik Blomstrand; Nicholas J Maragakis; Michael Nilsson; Milos Pekny
Protective role of reactive astrocytes in brain ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(3):468-81.
2008: Anne Angelillo-Scherrer; Laurent Burnier; Diether Lambrechts; Richard J Fish; Marc Tjwa; Stephane Plaisance; Rocco Sugamele; Maria DeMol; Eduardo Martinez-Soria; Patrick H Maxwell; Greg Lemke; Stephen P Goff; Glenn K Matsushima; Henry Earp; Marc Chanson; Désiré Collen; Shozo Izui; Marc Schapira; Edward M Conway; Peter Carmeliet
Role of Gas6 in erythropoiesis and anemia in mice.
The Journal of clinical investigation 2008;118(2):583-96.
2008: Peter Carmeliet
Neuro-vascular link: from genetic insights to therapeutic perspectives.
Bulletin et mémoires de l'Académie royale de médecine de Belgique 2008;163(10-12):445-51; discussion 451-2.
2008: Peter Hill; Deepa Shukla; Maxine G B Tran; Julian Aragones; H Terence Cook; Peter Carmeliet; Patrick H Maxwell
Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN 2008;19(1):39-46.
2008: Changli Wei; Clemens C Möller; Mehmet Mete Altintas; Jing Li; Karin Schwarz; Serena Zacchigna; Liang Xie; Anna Henger; Holger Schmid; Maria Pia Rastaldi; Peter Cowan; Matthias Kretzler; Roberto Parrilla; Moïse Bendayan; Vineet Gupta; Boris Nikolic; Raghu Kalluri; Peter Carmeliet; Peter Mundel; Jochen Reiser
Modification of kidney barrier function by the urokinase receptor.
Nature medicine 2008;14(1):55-63.
2008: Serena Zacchigna; Carmen Ruiz de Almodovar; Peter Carmeliet
Similarities between angiogenesis and neural development: what small animal models can tell us.
Current topics in developmental biology 2008;80():1-55.
2007: Camila V Esguerra; Luc Nelles; Liesbeth Vermeire; Abdelilah Ibrahimi; Alexander D Crawford; Rita Derua; Els Janssens; Etienne Waelkens; Peter Carmeliet; Desiré Collen; Danny Huylebroeck
Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.
Development (Cambridge, England) 2007;134(24):4381-93.
2007: Sònia Tugues; Guillermo Fernández-Varo; Javier Muñoz-Luque; Josefa Ros; Vicente Arroyo; Juan Rodés; Scott L Friedman; Peter Carmeliet; Wladimiro Jiménez; Manuel Morales-Ruiz
Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.
Hepatology (Baltimore, Md.) 2007;46(6):1919-26.
2007: Christian Fischer; Bart Jonckx; Massimiliano Mazzone; Serena Zacchigna; Sonja Loges; Lucia Pattarini; Emmanuel Chorianopoulos; Laurens Liesenborghs; Marta Koch; Maria De Mol; Monica Autiero; Sabine Wyns; Stephane Plaisance; Lieve Moons; Nico van Rooijen; Mauro Giacca; Jean Marie Stassen; Mieke Dewerchin; Désiré Collen; Peter Carmeliet
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
Cell 2007;131(3):463-75.
2007: Daniela Tirziu; Emmanuel Chorianopoulos; Karen L Moodie; Robert T Palac; Zhen W Zhuang; Marc Tjwa; Carmen Roncal; Ulf Eriksson; Qiangwei Fu; Arye Elfenbein; Amy E Hall; Peter Carmeliet; Lieve Moons; Michael Simons
Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice.
The Journal of clinical investigation 2007;117(11):3188-97.
2007: Massimiliano Mazzone; Carmen Ruiz de Almodovar; Peter Carmeliet
Building in resistance to endothelial cell death.
Nature genetics 2007;39(11):1308-9.
2007: Bruno Larrivée; Catarina Freitas; Marc Trombe; Xiang Lv; Benjamin Delafarge; Li Yuan; Karine Bouvrée; Christiane Bréant; Raquel Del Toro; Nicolas Bréchot; Stéphane Germain; Françoise Bono; Frédérique Dol; Filip Claes; Christian Fischer; Monica Autiero; Jean-Léon Thomas; Peter Carmeliet; Marc Tessier-Lavigne; Anne Eichmann
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis.
Genes & development 2007;21(19):2433-47.
2007: Diether Lambrechts; Wim Robberecht; Peter Carmeliet
Heterogeneity in motoneuron disease.
Trends in neurosciences 2007;30(10):536-44.
2007: Maud Jost; Catherine Maillard; Julie Lecomte; Vincent Lambert; Marc Tjwa; Pierre Blaise; Marie-Luz Alvarez-Gonzalez; Khalid Bajou; Silvia Blacher; Patrick Motte; Chantal Humblet; Marie-Paule Defresne; Marc Thiry; Francis Frankenne; André Gothot; Peter Carmeliet; Jean-Marie Rakic; Jean-Michel Foidart; Agnès Noël
Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I.
The American journal of pathology 2007;171(4):1369-80.
2007: Robin Lemmens; Annelies Van Hoecke; Nicole Hersmus; Veerle Geelen; Isabel D'Hollander; Vincent Thijs; Ludo Van Den Bosch; Peter Carmeliet; Wim Robberecht
Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish.
Human molecular genetics 2007;16(19):2359-65.
2007: Philip Van Damme; Elke Bogaert; Maarten Dewil; Nicole Hersmus; Dora Kiraly; Wendy Scheveneels; Ilse Bockx; Dries Braeken; Nathalie Verpoorten; Kristien Verhoeven; Vincent Timmerman; Paul Herijgers; Geert Callewaert; Peter Carmeliet; Ludo Van Den Bosch; Wim Robberecht
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(37):14825-30.
2007: Mònica Suelves; Berta Vidal; Antonio L Serrano; Marc Tjwa; Josep Roma; Roser López-Alemany; Aernout Luttun; María Martínez de Lagrán; Angels Díaz-Ramos; Maria Angels Díaz; Mercè Jardí; Manuel Roig; Mara Dierssen; Mieke Dewerchin; Peter Carmeliet; Pura Muñoz-Cánoves
uPA deficiency exacerbates muscular dystrophy in MDX mice.
The Journal of cell biology 2007;178(6):1039-51.
2007: Koh-Hei Sonoda; Takahiko Nakamura; Howard A Young; David Hart; Peter Carmeliet; Joan Stein-Streilein
NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2215-22.
2007: Mathias Cacquevel; Séverine Launay; Hervé Castel; Karim Benchenane; Simon Chéenne; Luc BUEE; Lieve Moons; André Delacourte; Peter Carmeliet; Denis Vivien
Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms.
Neurobiology of disease 2007;27(2):164-73.
2007: Philippe Leroux; Olivier Hennebert; H Legros; Vincent Laudenbach; Peter Carmeliet; Stéphane Marret
Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: interaction with plasmin inhibitors and anti-inflammatory drugs.
Neuroscience 2007;146(2):670-8.
2007: I Buysschaert; Peter Carmeliet; M Dewerchin
Clinical and fundamental aspects of angiogenesis and anti-angiogenesis.
Acta clinica Belgica 2007;62(3):162-9.
2007: Chandrakant Tayade; David Hilchie; Hong He; Yuan Fang; Lieve Moons; Peter Carmeliet; Robert A Foster; B Anne Croy
Genetic deletion of placenta growth factor in mice alters uterine NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4267-75.
2007: Vincent Laudenbach; Romain H Fontaine; Fadia Medja; Peter Carmeliet; Daniel J Hicklin; Jorge Gallego; Philippe Leroux; Stéphane Marret; Pierre Gressens
Neonatal hypoxic preconditioning involves vascular endothelial growth factor.
Neurobiology of disease 2007;26(1):243-52.
2007: Nynke van den Akker; Daniël G M Molin; Patricia P W M Peters; Saskia Maas; Lambertus J Wisse; Ronald van Brempt; Conny J van Munsteren; Margot M Bartelings; Robert E Poelmann; Peter Carmeliet; Adriana C Gittenberger-De Groot
Tetralogy of fallot and alterations in vascular endothelial growth factor-A signaling and notch signaling in mouse embryos solely expressing the VEGF120 isoform.
Circulation research 2007;100(6):842-9.
2007: Rosemarijn Renckens; Joris J T H Roelofs; Peter I Bonta; Sandrine Florquin; Carlie J M de Vries; Marcel Levi; Peter Carmeliet; Cornelis Van't Veer; Tom van der Poll
Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia.
Blood 2007;109(4):1593-601.
2007: Davy Vanhoutte; Mark Schellings; Martin Götte; Melissa Swinnen; Veronica Herias; Martin K Wild; Dietmar Vestweber; Emmanuel Chorianopoulos; Víctor Cortés; Attilio Rigotti; Mary-Ann Stepp; Frans Van de Werf; Peter Carmeliet; Yigal M Pinto; Stephane Heymans
Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction.
Circulation 2007;115(4):475-82.
2007: Paolo Giacobini; Andrea Messina; Susan Wray; Costanza Giampietro; crepaldi tiziana; Peter Carmeliet; Aldo Fasolo
Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(2):431-45.
2006: Carol Ann Remme; Arie O Verkerk; Dieter Nuyens; Antoni C G van Ginneken; Sandra van Brunschot; Charly N W Belterman; Ronald Wilders; Marian A van Roon; Hanno L Tan; Arthur A M Wilde; Peter Carmeliet; Jacques M T de Bakker; Marieke W Veldkamp; Connie R Bezzina
Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD.
Circulation 2006;114(24):2584-94.
2006: Ritsuko Masuyama; Ingrid Stockmans; Sophie Torrekens; Riet Van Looveren; Christa Maes; Peter Carmeliet; Roger Bouillon; Geert Carmeliet
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts.
The Journal of clinical investigation 2006;116(12):3150-9.
2006: Sandra Fredj; Nicolas Lindegger; Kevin J Sampson; Peter Carmeliet; Robert Kass
Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes.
Circulation research 2006;99(11):1225-32.
2006: Diether Lambrechts; Peter Carmeliet
VEGF at the neurovascular interface: therapeutic implications for motor neuron disease.
Biochimica et biophysica acta 2006;1762(11-12):1109-21.
2006: H Roger Lijnen; Valerie Christiaens; Ilse Scroyen; Gabor Voros; Marc Tjwa; Peter Carmeliet; Désiré Collen
Impaired adipose tissue development in mice with inactivation of placental growth factor function.
Diabetes 2006;55(10):2698-704.
2006: Yun He; Yan Luo; Shibo Tang; Iiro Rajantie; Petri Salven; Matthias Heil; Rong Zhang; Dianhong Luo; Xianghong Li; Hongbo Chi; Jun Yu; Peter Carmeliet; Wolfgang Schaper; Albert J Sinusas; William C Sessa; Kari Alitalo; Wang Min
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis.
The Journal of clinical investigation 2006;116(9):2344-55.
2006: Stephane Heymans; Matthias Pauschinger; Armando De Palma; Angela Kallwellis-Opara; Susanne Rutschow; Melissa Swinnen; Davy Vanhoutte; Fangye Gao; Raimund Torpai; Andrew H Baker; Elizaveta Padalko; Johan Neyts; Heinz-Peter Schultheiss; Frans Van de Werf; Peter Carmeliet; Yigal M Pinto
Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis.
Circulation 2006;114(6):565-73.
2006: Diether Lambrechts; Peggy Lafuste; Peter Carmeliet; Edward M Conway
Another angiogenic gene linked to amyotrophic lateral sclerosis.
Trends in molecular medicine 2006;12(8):345-7.
2006: David M Cochran; Dai Fukumura; Marek Ancukiewicz; Peter Carmeliet; Rakesh K Jain
Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Annals of biomedical engineering 2006;34(8):1247-58.
2006: Peter Vangheluwe; Marc Tjwa; An Van den Bergh; William E Louch; Monique Beullens; Leonard Dode; Peter Carmeliet; Evangelia G Kranias; Paul Herijgers; Karin R Sipido; Luc Raeymaekers; Frank Wuytack
A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span.
Journal of molecular and cellular cardiology 2006;41(2):308-17.
2006: Rosemarijn Renckens; Joris J T H Roelofs; Sandrine Florquin; Alex F de Vos; Jennie M Pater; H Roger Lijnen; Peter Carmeliet; Cornelis van 't Veer; Tom van der Poll
Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1189-96.
2006: Martin Schneider; Annelii Ny; Carmen Ruiz de Almodovar; Peter Carmeliet
A new mouse model to study acquired lymphedema.
PLoS medicine 2006;3(7):e264.
2006: Christian Fischer; Peter Carmeliet; Edward M Conway
VEGF inhibitors make blood.
Nature medicine 2006;12(7):732-4.
2006: Bin Li; Emerson E Sharpe; Amanda B Maupin; Amylynn A Teleron; Amy L Pyle; Peter Carmeliet; Pampee P Young
VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1495-7.
2006: Kiichiro Yano; Patricia C Liaw; Janet M Mullington; Shu-Ching Shih; Hitomi Okada; Natalya Bodyak; Peter M Kang; Lisa Toltl; Bryan Belikoff; Jon A Buras; Benjamin T Simms; Joseph P Mizgerd; Peter Carmeliet; S Ananth Karumanchi; William C Aird
Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.
The Journal of experimental medicine 2006;203(6):1447-58.
2006: Thomas W Chittenden; Filip Claes; Anthony A Lanahan; Monica Autiero; Robert T Palac; Eugene Tkachenko; Arye Elfenbein; Carmen Ruiz de Almodovar; Eduard I Dedkov; Robert Tomanek; Weiming Li; Michael Westmore; Jai Pal Singh; Arie Horowitz; Mary Jo Mulligan-Kehoe; Karen L Moodie; Zhen W Zhuang; Peter Carmeliet; Michael Simons
Selective regulation of arterial branching morphogenesis by synectin.
Developmental cell 2006;10(6):783-95.
2006: Stein Aerts; Diether Lambrechts; Sunit Maity; Peter Van Loo; Bert Coessens; Frank De Smet; Léon-Charles Tranchevent; Bart De Moor; Peter Marynen; Bassem A Hassan; Peter Carmeliet; Yves Moreau
Gene prioritization through genomic data fusion.
Nature biotechnology 2006;24(5):537-44.
2006: Frank De Smet; Peter Carmeliet; Monica Autiero
Fishing and frogging for anti-angiogenic drugs.
Nature chemical biology 2006;2(5):228-9.
2006: Christa Maes; Lieve Coenegrachts; Ingrid Stockmans; Evis Daci; Aernout Luttun; Anna Petryk; Rajaram Gopalakrishnan; Karen Moermans; Nico Smets; Catherine M Verfaillie; Peter Carmeliet; Roger Bouillon; Geert Carmeliet
Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair.
The Journal of clinical investigation 2006;116(5):1230-42.
2006: Marc Tjwa; Peter Carmeliet; Lieve Moons
Novel transgenic rabbit model sheds light on the puzzling role of matrix metalloproteinase-12 in atherosclerosis.
Circulation 2006;113(16):1929-32.
2006: Annelii Ny; Monica Autiero; Peter Carmeliet
Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis.
Experimental cell research 2006;312(5):684-93.
2006: Barbara Le Bras; Maria-José Barallobre; Jihane Homman-Ludiye; Annelii Ny; Sabine Wyns; Tuomas Tammela; Paula Haiko; Marika J Karkkainen; Li Yuan; Marie-Paule Muriel; Elli Chatzopoulou; Christiane Bréant; Bernard Zalc; Peter Carmeliet; Kari Alitalo; Anne Eichmann; Jean-Léon Thomas
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Nature neuroscience 2006;9(3):340-8.
2006: Patrick Rossignol; Aernout Luttun; Jose Luis Martin-Ventura; Florea Lupu; Peter Carmeliet; Désiré Collen; Eduardo Anglès-Cano; H Roger Lijnen
Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques.
Journal of thrombosis and haemostasis : JTH 2006;4(3):664-70.
2006: Jackelyn A Alva; Ann C Zovein; Arnaud Monvoisin; Thomas Murphy; Anthony Salazar; Natasha L Harvey; Peter Carmeliet; M Luisa Iruela-Arispe
VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(3):759-67.
2006: Stanley A Vinores; Wei-Hong Xiao; Sadia Aslam; Jikui Shen; Yuji Oshima; Hiroyuki Nambu; Hansheng Liu; Peter Carmeliet; Peter A Campochiaro
Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development.
Journal of cellular physiology 2006;206(3):749-58.
2006: Carmen Ruiz de Almodovar; Aernout Luttun; Peter Carmeliet
An SDF-1 trap for myeloid cells stimulates angiogenesis.
Cell 2006;124(1):18-21.
2006: C Fischer; M Schneider; Peter Carmeliet
Principles and therapeutic implications of angiogenesis, vasculogenesis and arteriogenesis.
Handbook of experimental pharmacology 2006;(176 Pt 2):157-212.
2005: Peter Carmeliet
Angiogenesis in life, disease and medicine.
Nature 2005;438(7070):932-6.
2005: Himadri Roy; Shalini Bhardwaj; Mohan Babu; Suvi Jauhiainen; Karl-Heinz Herzig; Anna R Bellu; Hidde J Haisma; Peter Carmeliet; Kari Alitalo; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A.
Human gene therapy 2005;16(12):1422-8.
2005: Søren Krag; Carl Christian Danielsen; Peter Carmeliet; Jens R Nyengaard; Lise Wogensen
Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease.
Kidney international 2005;68(6):2651-66.
2005: Karen D Cowden Dahl; Benjamin H Fryer; Fiona A Mack; Veerle Compernolle; Emin Maltepe; David M Adelman; Peter Carmeliet; M Celeste Simon
Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.
Molecular and cellular biology 2005;25(23):10479-91.
2005: Martin Schneider; Edward M Conway; Peter Carmeliet
Lymph makes you fat.
Nature genetics 2005;37(10):1023-4.
2005: Alexander de Giorgio-Miller; Stephen E Bottoms; Geoffrey Laurent; Peter Carmeliet; Sarah E Herrick
Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator.
The American journal of pathology 2005;167(3):721-32.
2005: Annelii Ny; Marta Koch; Martin Schneider; Elke Neven; Ricky T Tong; Sunit Maity; Christian Fischer; Stephane Plaisance; Diether Lambrechts; Christophe Héligon; Sven Terclavers; Malgorzata Ciesiolka; Roland Kälin; Wing Yan Man; Irena Senn; Sabine Wyns; Florea Lupu; André Brändli; Kris Vleminckx; Désiré Collen; Mieke Dewerchin; Edward M Conway; Lieve Moons; Rakesh K Jain; Peter Carmeliet
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nature medicine 2005;11(9):998-1004.
2005: Stephane Heymans; Blanche Schroen; Pieter Vermeersch; Hendrik Milting; Fangye Gao; Astrid Kassner; Hilde Gillijns; Paul Herijgers; Willem Flameng; Peter Carmeliet; Frans Van de Werf; Yigal M Pinto; Stefan Janssens
Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart.
Circulation 2005;112(8):1136-44.
2005: Ilka Ott; Cornelia Michaelis; Maren Schuermann; Birgit Steppich; Isabell Seitz; Mieke Dewerchin; Dietlind Zohlnhofer; Rainer Wessely; Martina Rudelius; Albert Schömig; Peter Carmeliet
Vascular remodeling in mice lacking the cytoplasmic domain of tissue factor.
Circulation research 2005;97(3):293-8.
2005: Till Acker; Antonio Diez-juan; Julian Aragones; Marc Tjwa; Koen Brusselmans; Lieve Moons; Dai Fukumura; Maria Paz Moreno-Murciano; Jean-Marc Herbert; Angelika Burger; Johanna Riedel; Gerd Elvert; Ingo Flamme; Patrick H Maxwell; Désiré Collen; Mieke Dewerchin; Rakesh K Jain; Karl H Plate; Peter Carmeliet
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer cell 2005;8(2):131-41.
2005: Els Melis; Lieve Moons; Jef Arnout; Marc F Hoylaerts; Désiré Collen; Peter Carmeliet; Mieke Dewerchin
Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain.
Biochemical and biophysical research communications 2005;333(2):488-95.
2005: Susanna M Müller; Grzegorz Terszowski; Carmen Blum; Corinne Haller; Viviane Anquez; Stephen Kuschert; Peter Carmeliet; Hellmut G Augustin; Hans-Reimer Rodewald
Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10587-92.
2005: Peter Carmeliet; Marc Tessier-Lavigne
Common mechanisms of nerve and blood vessel wiring.
Nature 2005;436(7048):193-200.
2005: Lucia Zanetta; Monica Corada; Maria Grazia Lampugnani; Adriana Zanetti; Ferruccio Breviario; Lieve Moons; Peter Carmeliet; Michael S Pepper; Elisabetta Dejana
Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications.
Thrombosis and haemostasis 2005;93(6):1041-6.
2005: Rohit Khurana; Lieve Moons; Shahida Shafi; Aernout Luttun; Désiré Collen; John F Martin; Peter Carmeliet; Ian Zachary
Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation.
Circulation 2005;111(21):2828-36.
2005: Rosemarijn Renckens; Joris J T H Roelofs; Vivian de Waard; Sandrine Florquin; H Roger Lijnen; Peter Carmeliet; Tom van der Poll
The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury.
Journal of thrombosis and haemostasis : JTH 2005;3(5):1018-25.
2005: Tom Rossenbacker; E Schollen; Cuno Kuipéri; T J L de Ravel; koenraad devriendt; G Matthijs; Désiré Collen; Hein Heidbüchel; Peter Carmeliet
Unconventional intronic splice site mutation in SCN5A associates with cardiac sodium channelopathy.
Journal of medical genetics 2005;42(5):e29.
2005: Erik Maquoi; Gabor Vörös; Peter Carmeliet; Désiré Collen; H Roger Lijnen
Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):1002-7.
2005: Michael R Taylor; Satoshi Kikkawa; Antonio Diez-juan; Visvanathan Ramamurthy; Koichi Kawakami; Peter Carmeliet; Susan E Brockerhoff
The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells.
Genetics 2005;170(1):263-73.
2005: Tom Rossenbacker; Kanigula Mubagwa; Roselie J Jongbloed; Johan Vereecke; koenraad devriendt; Marc Gewillig; Edward Carmeliet; Désiré Collen; Hein Heidbüchel; Peter Carmeliet
Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome.
Circulation 2005;111(8):961-8.
2005: Monica Autiero; Frank De Smet; Filip Claes; Peter Carmeliet
Role of neural guidance signals in blood vessel navigation.
Cardiovascular research 2005;65(3):629-38.
2005: Koen Brusselmans; Françoise Bono; Désiré Collen; Jean-Marc Herbert; Peter Carmeliet; Mieke Dewerchin
A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia.
The Journal of biological chemistry 2005;280(5):3493-9.
2005: Anne Eichmann; Ferdinand le Noble; Monica Autiero; Peter Carmeliet
Guidance of vascular and neural network formation.
Current opinion in neurobiology 2005;15(1):108-15.
2005: Anne Angelillo-Scherrer; Laurent Burnier; Nathalie Flores; Pierre Savi; Maria DeMol; Paul Schaeffer; Jean-Marc Herbert; Greg Lemke; Stephen P Goff; Glenn K Matsushima; Henry Earp; Christian Vesin; Marc F Hoylaerts; Stephane Plaisance; Désiré Collen; Edward M Conway; Bernhard Wehrle-Haller; Peter Carmeliet
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
The Journal of clinical investigation 2005;115(2):237-46.
2005: Ilona Kryczek; Andrzej Lange; Peter Mottram; Xavier Alvarez; Pui Cheng; Melina Hogan; Lieve Moons; Shuang Wei; Linhua Zou; Véronique Machelon; Dominique Emilie; Margarita Terrassa; Andrew Lackner; Tyler J Curiel; Peter Carmeliet; Weiping Zou
CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.
Cancer research 2005;65(2):465-72.
2005: Peter Carmeliet
VEGF as a key mediator of angiogenesis in cancer.
Oncology 2005;69 Suppl 3():4-10.
2005: Catherine Maillard; Maud Jost; Maria Unni Rømer; Nils Brunner; Xavier Houard; Annabelle Lejeune; Carine Munaut; Khalid Bajou; Laurence Melen; Keld Dano; Peter Carmeliet; Norbert E Fusenig; Jean-Michel Foidart; Agnès Noel
Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner.
Neoplasia (New York, N.Y.) 2005;7(1):57-66.
2005: Martin Schneider; Marc Tjwa; Peter Carmeliet
A surrogate marker to monitor angiogenesis at last.
Cancer cell 2005;7(1):3-4.
2005: Stephane Heymans; Florea Lupu; Sven Terclavers; Bjorn Vanwetswinkel; Jean-Marc Herbert; Andrew Baker; Désiré Collen; Peter Carmeliet; Lieve Moons
Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice.
The American journal of pathology 2005;166(1):15-25.
2005: Xuri Li; Marc Tjwa; Lieve Moons; Pierre Fons; Agnès Noel; Annelii Ny; Jian Min Zhou; Johan Lennartsson; Hong Li; Aernout Luttun; Annica Pontén; Laetitia Devy; Ann Bouché; Hideyasu Oh; Ann Manderveld; Silvia Blacher; David Communi; Pierre Savi; Françoise Bono; Mieke Dewerchin; Jean-Michel Foidart; Monica Autiero; Jean-Marc Herbert; Désiré Collen; Carl-Henrik Heldin; Ulf Eriksson; Peter Carmeliet
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
The Journal of clinical investigation 2005;115(1):118-27.
2005: Jürgen Krücken; Mohamed A Dkhil; Juliane V Braun; Regina M U Schroetel; Manal El-Khadragy; Peter Carmeliet; Horst Mossmann; Frank Wunderlich
Testosterone suppresses protective responses of the liver to blood-stage malaria.
Infection and immunity 2005;73(1):436-43.
2005: Olivier Hennebert; Vincent Laudenbach; Annie Laquerriere; C Verney; Peter Carmeliet; Stéphane Marret; Philippe Leroux
Ontogenic study of the influence of tissue plasminogen activator (t-PA) in neonatal excitotoxic brain insult and the subsequent microglia/macrophage activation.
Neuroscience 2005;130(3):697-712.
2005: Erik Storkebaum; Diether Lambrechts; Mieke Dewerchin; Maria-Paz Moreno-Murciano; Saskia Appelmans; Hideyasu Oh; Philip Van Damme; Bart Rutten; Wing Yan Man; Maria De Mol; Sabine Wyns; David Manka; Kristel Vermeulen; Ludo Van Den Bosch; Nico Mertens; Christoph Schmitz; Wim Robberecht; Edward M Conway; Désiré Collen; Lieve Moons; Peter Carmeliet
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.
Nature neuroscience 2005;8(1):85-92.
2004: Antoine Alam; Jean-Pascal Herault; Pauline Barron; Benoit Favier; Pierre Fons; Nathalie Delesque-Touchard; Isabelle Senegas; Patricia Laboudie; Jacques Bonnin; Cecile Cassan; Pierre Savi; Bruce Ruggeri; Peter Carmeliet; Françoise Bono; Jean-Marc Herbert
Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity.
Biochemical and biophysical research communications 2004;324(2):909-15.
2004: Xiaowei Lu; Ferdinand le Noble; Li Yuan; Quingjan Jiang; Benjamin De Lafarge; Daisuke Sugiyama; Christiane Bréant; Filip Claes; Frank De Smet; Jean-Léon Thomas; Monica Autiero; Peter Carmeliet; Marc Tessier-Lavigne; Anne Eichmann
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Nature 2004;432(7014):179-86.
2004: Tom Rossenbacker; Sheila J Carroll; Huajun Liu; Cuno Kuipéri; T J L de Ravel; koenraad devriendt; Peter Carmeliet; Robert Kass; Hein Heidbüchel
Novel pore mutation in SCN5A manifests as a spectrum of phenotypes ranging from atrial flutter, conduction disease, and Brugada syndrome to sudden cardiac death.
Heart rhythm : the official journal of the Heart Rhythm Society 2004;1(5):610-5.
2004: Carlos Roger Molinas; Maria Mercedes Binda; Peter Carmeliet; Philippe Robert Koninckx
Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice.
Fertility and sterility 2004;82 Suppl 3():1149-53.
2004: Ludo Van Den Bosch; Erik Storkebaum; Vicky Vleminckx; Lieve Moons; Ludo Vanopdenbosch; Wendy Scheveneels; Peter Carmeliet; Wim Robberecht
Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration.
Neurobiology of disease 2004;17(1):21-8.
2004: Khalid Bajou; Catherine Maillard; Maud Jost; Roger H Lijnen; Ann Gils; Paul J Declerck; Peter Carmeliet; Jean-Michel Foidart; Agnès Noel
Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth.
Oncogene 2004;23(41):6986-90.
2004: Diether Lambrechts; Peter Carmeliet
Sculpting heart valves with NFATc and VEGF.
Cell 2004;118(5):532-4.
2004: Erik Storkebaum; Diether Lambrechts; Peter Carmeliet
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection.
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(9):943-54.
2004: Tyler J Curiel; Pui Cheng; Peter Mottram; Xavier Alvarez; Lieve Moons; Melina Evdemon-Hogan; Shuang Wei; Linhua Zou; Ilona Kryczek; Gary Hoyle; Andrew Lackner; Peter Carmeliet; Weiping Zou
Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer.
Cancer research 2004;64(16):5535-8.
2004: Andrea Lundkvist; Andreas Reichenbach; Christer Betsholtz; Peter Carmeliet; Hartwig Wolburg; Milos Pekny
Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences.
Journal of cell science 2004;117(Pt 16):3481-8.
2004: Aernout Luttun; Peter Carmeliet
Angiogenesis and lymphangiogenesis: highlights of the past year.
Current opinion in hematology 2004;11(4):262-71.
2004: Laveena Sharma; Els Melis; Michael J Hickey; Colin D Clyne; Jonathan Erlich; Levon M Khachigian; Piers Davenport; Eric F Morand; Peter Carmeliet; Peter G Tipping
The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia.
The American journal of pathology 2004;165(1):331-40.
2004: Kristy L Edgtton; Renae M Gow; Darren J Kelly; Peter Carmeliet; A Richard Kitching
Plasmin is not protective in experimental renal interstitial fibrosis.
Kidney international 2004;66(1):68-76.
2004: Aleyde van Eynde; Mieke Nuytten; Mieke Dewerchin; Luc Schoonjans; Stefaan Keppens; Monique Beullens; Lieve Moons; Peter Carmeliet; Willy Stalmans; Mathieu Bollen
The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.
Molecular and cellular biology 2004;24(13):5863-74.
2004: Diether Lambrechts; Erik Storkebaum; Peter Carmeliet
VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS?
Trends in molecular medicine 2004;10(6):275-82.
2004: Mimoun Azzouz; G Scott Ralph; Erik Storkebaum; Lucy E Walmsley; Kyriacos A Mitrophanous; Susan M Kingsman; Peter Carmeliet; Nicholas D Mazarakis
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model.
Nature 2004;429(6990):413-7.
2004: Mattias Belting; Michael I Dorrell; Staffan Sandgren; Edith Aguilar; Jasimuddin Ahamed; Andrea Dorfleutner; Peter Carmeliet; Barbara M Mueller; Martin Friedlander; Wolfram Ruf
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.
Nature medicine 2004;10(5):502-9.
2004: Peter Carmeliet
Manipulating angiogenesis in medicine.
Journal of internal medicine 2004;255(5):538-61.
2004: Aernout Luttun; Esther Lutgens; Ann Manderveld; Katleen Maris; Désiré Collen; Peter Carmeliet; Lieve Moons
Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth.
Circulation 2004;109(11):1408-14.
2004: Aernout Luttun; Monica Autiero; Marc Tjwa; Peter Carmeliet
Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?
Biochimica et biophysica acta 2004;1654(1):79-94.
2004: Diether Lambrechts; Peter Carmeliet
Medicine: genetic spotlight on a blood defect.
Nature 2004;427(6975):592-4.
2004: Karel De Gendt; Johannes V Swinnen; Philippa Saunders; Luc Schoonjans; Mieke Dewerchin; Ann Devos; Karen Tan; Nina Atanassova; Frank Claessens; Charlotte Lécureuil; Walter Heyns; Peter Carmeliet; Florian Guillou; Richard M Sharpe; Guido Verhoeven
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1327-32.
2004: Diether Lambrechts; Peter Carmeliet
Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF.
Current topics in developmental biology 2004;62():189-224.
2004: Edward M Conway; Peter Carmeliet
The diversity of endothelial cells: a challenge for therapeutic angiogenesis.
Genome biology 2004;5(2):207.
2004: Olivier Hennebert; Stéphane Marret; Peter Carmeliet; Pierre Gressens; Annie Laquerrière; Philippe Leroux
Role of tissue-derived plasminogen activator (t-PA) in an excitotoxic mouse model of neonatal white matter lesions.
Journal of neuropathology and experimental neurology 2004;63(1):53-63.
2004: Christa Maes; Ingrid Stockmans; Karen Moermans; Riet Van Looveren; Nico Smets; Peter Carmeliet; Roger Bouillon; Geert Carmeliet
Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival.
The Journal of clinical investigation 2004;113(2):188-99.
2004: Erik Storkebaum; Peter Carmeliet
VEGF: a critical player in neurodegeneration.
The Journal of clinical investigation 2004;113(1):14-8.
2004: Yuan H Yang; Pam Hall; Georgia Milenkovski; Laveena Sharma; Paul Hutchinson; Els Melis; Peter Carmeliet; Peter G Tipping; Eric F Morand
Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice.
The American journal of pathology 2004;164(1):109-17.
2004: Elizaveta Padalko; Dieter Nuyens; Armando De Palma; Erik Verbeken; Joeri L Aerts; Erik De Clercq; Peter Carmeliet; Johan Neyts
The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis.
Antimicrobial agents and chemotherapy 2004;48(1):267-74.
2003: Veerle Compernolle; Koen Brusselmans; Diego Franco; Antoon Moorman; Mieke Dewerchin; Désiré Collen; Peter Carmeliet
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha.
Cardiovascular research 2003;60(3):569-79.
2003: Mieke Dewerchin; Jean-Pascal Hérault; Goedele Wallays; Maurice Petitou; Paul Schaeffer; Laurence Millet; Jeffrey I Weitz; Lieve Moons; Désiré Collen; Peter Carmeliet; Jean-Marc Herbert
Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin.
Circulation research 2003;93(11):1120-6.
2003: Tom A Drixler; J Mathijs Vogten; Martijn F B G Gebbink; Peter Carmeliet; Emile E Voest; Inne H M Borel Rinkes
Plasminogen mediates liver regeneration and angiogenesis after experimental partial hepatectomy.
The British journal of surgery 2003;90(11):1384-90.
2003: Anneleen Janssen; Pierre Gressens; Markus Grabenbauer; Eveline Baumgart; Arno Schad; Ilse Vanhorebeek; Annelies Brouwers; Peter E Declercq; Dariush Fahimi; Philippe Evrard; Luc Schoonjans; Désiré Collen; Peter Carmeliet; Guy P Mannaerts; Paul P Van Veldhoven; Myriam Baes
Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(30):9732-41.
2003: Sophie van Cromphaut; Katrien Rummens; Ingrid Stockmans; Erik Van Herck; F A Dijcks; Antwan Ederveen; Peter Carmeliet; Johan Verhaeghe; Roger Bouillon; Geert Carmeliet
Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(10):1725-36.
2003: Marc Tjwa; Aernout Luttun; Monica Autiero; Peter Carmeliet
VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis.
Cell and tissue research 2003;314(1):5-14.
2003: Alexandre Hertig; Jeannig Berrou; Yves Allory; Laetitia Breton; Frédéric Commo; Marie-Alyette Costa De Beauregard; Peter Carmeliet; Eric Rondeau
Type 1 plasminogen activator inhibitor deficiency aggravates the course of experimental glomerulonephritis through overactivation of transforming growth factor beta.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1904-6.
2003: Pedro Brites; Alison M Motley; Pierre Gressens; Petra A W Mooyer; Ingrid Ploegaert; Vincent Everts; Philippe Evrard; Peter Carmeliet; Mieke Dewerchin; Luc Schoonjans; Marinus Duran; Hans R Waterham; Ronald J A Wanders; Myriam Baes
Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata.
Human molecular genetics 2003;12(18):2255-67.
2003: Edward M Conway; Peter Carmeliet
Cardiovascular biology: signalling silenced.
Nature 2003;425(6954):139-41.
2003: Carlos Roger Molinas; Rudi Campo; Mieke Dewerchin; Ulf Eriksson; Peter Carmeliet; Philippe Robert Koninckx
Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice.
Fertility and sterility 2003;80 Suppl 2():803-11.
2003: Carlos Roger Molinas; Rudi Campo; Osama Ali Elkelani; Maria Mercedes Binda; Peter Carmeliet; Philippe Robert Koninckx
Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice.
Fertility and sterility 2003;80 Suppl 2():795-802.
2003: Peter Carmeliet
Blood vessels and nerves: common signals, pathways and diseases.
Nature reviews. Genetics 2003;4(9):710-20.
2003: Anita W Rijneveld; Sandrine Florquin; Paul Bresser; Marcel Levi; Vivian de Waard; Roger Lijnen; jaring s. van der zee; Peter Speelman; Peter Carmeliet; Tom van der Poll
Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia.
Blood 2003;102(3):934-9.
2003: Monica Autiero; Aernout Luttun; Marc Tjwa; Peter Carmeliet
Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1356-70.
2003: Carlos Roger Molinas; Osama Ali Elkelani; Rudi Campo; Aernout Luttun; Peter Carmeliet; Philippe Robert Koninckx
Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice.
Fertility and sterility 2003;80(1):184-92.
2003: Jean-Marie Rakic; Vincent Lambert; Laetitia Devy; Aernout Luttun; Peter Carmeliet; Carel Claes; Laurent Nguyen; Jean-Michel Foidart; Agnès Noël; Carine Munaut
Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization.
Investigative ophthalmology & visual science 2003;44(7):3186-93.
2003: Monica Autiero; Johannes Waltenberger; David Communi; Andrea Kranz; Lieve Moons; Diether Lambrechts; Jens Kroll; Stephane Plaisance; Maria De Mol; Françoise Bono; Stefanie Kliche; Guido Fellbrich; Kurt Ballmer-Hofer; Domenico Maglione; Ulrike Mayr-Beyrle; Mieke Dewerchin; Saskia Dombrowski; Danica Stanimirovic; Paul van Hummelen; Christoph Dehio; Daniel J Hicklin; Graziella Persico; Jean-Marc Herbert; David Communi; Masabumi Shibuya; Désiré Collen; Edward M Conway; Peter Carmeliet
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
Nature medicine 2003;9(7):936-43.
2003: Marcel Levi; Janine Dörffler-Melly; Pieter H Reitsma; Harry Buller; Sandrine Florquin; Tom van der Poll; Peter Carmeliet
Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.
Blood 2003;101(12):4823-7.
2003: Arie Reijerkerk; Laurent O Mosnier; Onno Kranenburg; Bonno N Bouma; Peter Carmeliet; Tom A Drixler; Joost C M Meijers; Emile E Voest; Martijn F B G Gebbink
Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system.
Molecular cancer research : MCR 2003;1(8):561-8.
2003: Peter Carmeliet
Angiogenesis in health and disease.
Nature medicine 2003;9(6):653-60.
2003: Vincent Lambert; Carine Munaut; Peter Carmeliet; Robert D Gerard; Paul J Declerck; Ann Gils; Carel Claes; Jean-Michel Foidart; Agnès Noël; Jean-Marie Rakic
Dose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type I: implications for clinical trials.
Investigative ophthalmology & visual science 2003;44(6):2791-7.
2003: A Richard Kitching; Yao Z Kong; Xiao Ru Huang; Piers Davenport; Kristy L Edgtton; Peter Carmeliet; Stephen R Holdsworth; Peter G Tipping
Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2003;14(6):1487-95.
2003: Elisabeth Deindl; T Ziegelhöffer; S M Kanse; Borja Fernandez; E Neubauer; Peter Carmeliet; K T Preissner; Wolfgang Schaper
Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1174-6.
2003: Aernout Luttun; Peter Carmeliet
De novo vasculogenesis in the heart.
Cardiovascular research 2003;58(2):378-89.
2003: Koen Brusselmans; Veerle Compernolle; Marc Tjwa; Michael S Wiesener; Patrick H Maxwell; Désiré Collen; Peter Carmeliet
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.
The Journal of clinical investigation 2003;111(10):1519-27.
2003: Guoqiang Zhang; Heungsoo Kim; Xiaohe Cai; Jesús M López-Guisa; Charles E Alpers; Youhua Liu; Peter Carmeliet; Allison A Eddy
Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.
Journal of the American Society of Nephrology : JASN 2003;14(5):1254-71.
2003: Guoqiang Zhang; Heungsoo Kim; Xiaohe Cai; Jesus M Lopez-Guisa; Peter Carmeliet; Allison A Eddy
Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.
Journal of the American Society of Nephrology : JASN 2003;14(5):1234-53.
2003: Cristina Roca; Luca Primo; Donatella Valdembri; Anna Cividalli; Paul Declerck; Peter Carmeliet; Pietro Gabriele; Federico Bussolino
Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism.
Cancer research 2003;63(7):1500-7.
2003: Jean-Marie Rakic; Vincent Lambert; Carine Munaut; Khalid Bajou; Karine Peyrollier; Marie-Luz Alvarez-Gonzalez; Peter Carmeliet; Jean-Michel Foidart; Agnès Noël
Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization.
Investigative ophthalmology & visual science 2003;44(4):1732-9.
2003: Claus J Gruss; Kapaettu Satyamoorthy; Carola Berking; John Lininger; Mark Nesbit; Helmut Schaider; Zhao-Jun Liu; Masahiro Oka; Mei-Yu Hsu; Takashi Shirakawa; Gang Li; Thomas Bogenrieder; Peter Carmeliet; Wafik S El-Deiry; Stephen L Eck; Justi S Rao; Andrew H Baker; Jean T Bennet; Timothy M Crombleholme; Omaida Velazquez; Jagajan Karmacharya; David J Margolis; James M Wilson; Michael Detmar; Mihaela Skobe; Paul D Robbins; Clayton Buck; Meenhard Herlyn
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice.
The Journal of investigative dermatology 2003;120(4):683-92.
2003: Gary G Deng; Baby Martin-McNulty; Drew A Sukovich; Ana Freay; Meredith Halks-Miller; Therese Thinnes; David J Loskutoff; Peter Carmeliet; William P Dole; Yi-Xin Wang
Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm.
Circulation research 2003;92(5):510-7.
2003: Larissa Fabritz; Paulus Kirchhof; Michael R Franz; Dieter Nuyens; Tom Rossenbacker; Alexander Ottenhof; Wilhelm Haverkamp; Günter Breithardt; Edward Carmeliet; Peter Carmeliet
Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice.
Cardiovascular research 2003;57(4):1085-93.
2003: Frederic Pipp; Matthias Heil; Katja Issbrücker; Tibor Ziegelhoeffer; Sandra Martin; Joop van den Heuvel; Herbert Weich; Borja Fernandez; Gershon Golomb; Peter Carmeliet; Wolfgang Schaper; Matthias Clauss
VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism.
Circulation research 2003;92(4):378-85.
2003: Aernout Luttun; Peter Carmeliet
Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?
The Journal of clinical investigation 2003;111(5):600-2.
2003: Dimitri Scholz; Hanno Elsaesser; Annegret Sauer; Christian Friedrich; Aernout Luttun; Peter Carmeliet; Wolfgang Schaper
Bone marrow transplantation abolishes inhibition of arteriogenesis in placenta growth factor (PlGF) -/- mice.
Journal of molecular and cellular cardiology 2003;35(2):177-84.
2003: Hajimu Oura; Jennifer Bertoncini; Paula Velasco; Lawrence F Brown; Peter Carmeliet; Michael Detmar
A critical role of placental growth factor in the induction of inflammation and edema formation.
Blood 2003;101(2):560-7.
2003: Tao Jin; Andrej Tarkowski; Peter Carmeliet; Maria Bokarewa
Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis.
Arthritis research & therapy 2003;5(1):R9-R17.
2002: Aernout Luttun; Marc Tjwa; Peter Carmeliet
Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders.
Annals of the New York Academy of Sciences 2002;979():80-93.
2002: Fabian Docagne; Olivier Nicole; Cecilia Gabriel; monica fernandez-monreal; Sylvain Lesné; Carine Ali; Laurent Plawinski; Peter Carmeliet; Eric T MacKenzie; Alain Buisson; Denis Vivien
Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis.
Molecular and cellular neurosciences 2002;21(4):634-44.
2002: Vivian de Waard; E Karin Arkenbout; Peter Carmeliet; Volkhard Lindner; Hans Pannekoek
Plasminogen activator inhibitor 1 and vitronectin protect against stenosis in a murine carotid artery ligation model.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(12):1978-83.
2002: Francesco Blasi; Peter Carmeliet
uPAR: a versatile signalling orchestrator.
Nature reviews. Molecular cell biology 2002;3(12):932-43.
2002: Rafal Pawlinski; A Fernandes; Bettina Kehrle; Brian Pedersen; G Parry; Jonathan Erlich; Robert T Pyo; D Gutstein; J Zhang; F Castellino; Els Melis; Peter Carmeliet; G Baretton; Thomas Luther; M Taubman; E Rosen; Nigel Mackman
Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15333-8.
2002: Aernout Luttun; Marc Tjwa; Lieve Moons; Yan Wu; Anne Angelillo-Scherrer; Fang Liao; Janice A Nagy; Andrea Hooper; Josef Priller; Bert De Klerck; Veerle Compernolle; Evis Daci; Peter Bohlen; Mieke Dewerchin; Jean-Marc Herbert; Roy Fava; Patrick Matthys; Geert Carmeliet; Désiré Collen; Harold F Dvorak; Daniel J Hicklin; Peter Carmeliet
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.
Nature medicine 2002;8(8):831-40.
2002: Aernout Luttun; Koen Brusselmans; Hideharu Fukao; Marc Tjwa; Shigeru Ueshima; Jean-Marc Herbert; Osamu Matsuo; Désiré Collen; Peter Carmeliet; Lieve Moons
Loss of placental growth factor protects mice against vascular permeability in pathological conditions.
Biochemical and biophysical research communications 2002;295(2):428-34.
2002: Veerle Compernolle; Koen Brusselmans; Till Acker; Peter Hoet; Marc Tjwa; Heike Beck; Stephane Plaisance; Yuval Dor; Eli Keshet; Florea Lupu; Benoit Nemery; Mieke Dewerchin; Paul P Van Veldhoven; Karl H Plate; Lieve Moons; Désiré Collen; Peter Carmeliet
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.
Nature medicine 2002;8(7):702-10.
2002: Virginie Mattot; Lieve Moons; Florea Lupu; Daniel Chernavvsky; R Ariel Gómez; Désiré Collen; Peter Carmeliet
Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice.
Journal of the American Society of Nephrology : JASN 2002;13(6):1548-60.
2002: Yuval Dor; Valentin Djonov; Rinat Abramovitch; Ahuva Itin; Glenn I Fishman; Peter Carmeliet; Gadi Goelman; Eli Keshet
Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy.
The EMBO journal 2002;21(8):1939-47.
2002: Mònica Suelves; Roser López-Alemany; Frederic Lluís; Gloria Aniorte; Erika Serrano; Maribel Parra; Peter Carmeliet; Pura Muñoz-Cánoves
Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo.
Blood 2002;99(8):2835-44.
2002: Kari Alitalo; Peter Carmeliet
Molecular mechanisms of lymphangiogenesis in health and disease.
Cancer cell 2002;1(3):219-27.
2002: Heike Beck; Till Acker; Andreas W Püschel; Hajime Fujisawa; Peter Carmeliet; Karl H Plate
Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling.
Journal of neuropathology and experimental neurology 2002;61(4):339-50.
2002: Anita W Rijneveld; Marcel Levi; Sandrine Florquin; Peter Speelman; Peter Carmeliet; Tom van der Poll
Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3507-11.
2002: Aernout Luttun; Florea Lupu; Erik Storkebaum; Marc F Hoylaerts; Lieve Moons; James Crawley; Françoise Bono; A Robin Poole; Peter Tipping; Jean-Marc Herbert; Désiré Collen; Peter Carmeliet
Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):499-505.
2002: Hidefumi Kojima; Hua Gu; Saeko Nomura; Charles C Caldwell; Tetsuji Kobata; Peter Carmeliet; Gregg L Semenza; Michail V Sitkovsky
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2170-4.
2002: Peter Carmeliet; Erik Storkebaum
Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders.
Seminars in cell & developmental biology 2002;13(1):39-53.
2002: Myriam Baes; Mieke Dewerchin; Anneleen Janssen; Désiré Collen; Peter Carmeliet
Generation of Pex5-loxP mice allowing the conditional elimination of peroxisomes.
Genesis (New York, N.Y. : 2000) 2002;32(2):177-8.
2002: Aernout Luttun; Geert Carmeliet; Peter Carmeliet
Vascular progenitors: from biology to treatment.
Trends in cardiovascular medicine 2002;12(2):88-96.
2002: Ingeborg Stalmans; Yin-Shan Ng; Richard M Rohan; Marcus Fruttiger; Ann Bouché; Ali Yuce; Hajime Fujisawa; Bart Hermans; Moshe Shani; Sandra Jansen; Daniel J Hicklin; David J Anderson; Tom Gardiner; Hans-Peter Hammes; Lieve Moons; Mieke Dewerchin; Désiré Collen; Peter Carmeliet; Patricia A D'Amore
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms.
The Journal of clinical investigation 2002;109(3):327-36.
2002: Laetitia Devy; Silvia Blacher; Christine Grignet-Debrus; Khalid Bajou; Véronique Masson; Robert D Gerard; Ann Gils; Geert Carmeliet; Peter Carmeliet; Paul J Declerck; Agnès Nöel; Jean-Michel Foidart
The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(2):147-54.
2002: Christa Maes; Peter Carmeliet; Karen Moermans; Ingrid Stockmans; Nico Smets; Désiré Collen; Roger Bouillon; Geert Carmeliet
Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.
Mechanisms of development 2002;111(1-2):61-73.
2002: Peter Carmeliet
Integrin indecision.
Nature medicine 2002;8(1):14-6.
2001: Aernout Luttun; Peter Carmeliet
Genetic studies on the role of proteinases and growth factors in atherosclerosis and aneurysm formation.
Annals of the New York Academy of Sciences 2001;947():124-32; discussion 132-3.
2001: Sophie van Cromphaut; Mieke Dewerchin; Joost G J Hoenderop; Ingrid Stockmans; Erik Van Herck; S Kato; René J M Bindels; Désiré Collen; Peter Carmeliet; Roger Bouillon; Geert Carmeliet
Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13324-9.
2001: Mark Ver Heyen; Stephane Heymans; Gudrun Antoons; T Reed; Muthu Periasamy; Bonaventure L Awede; Jean Lebacq; Peter Vangheluwe; Mieke Dewerchin; Désiré Collen; Karin R Sipido; Peter Carmeliet; Frank Wuytack
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
Circulation research 2001;89(9):838-46.
2001: Koen Brusselmans; Françoise Bono; P Maxwell; Yuval Dor; Mieke Dewerchin; Désiré Collen; Jean-Marc Herbert; Peter Carmeliet
Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia.
The Journal of biological chemistry 2001;276(42):39192-6.
2001: Dieter Nuyens; Milan Stengl; S Dugarmaa; Tom Rossenbacker; Veerle Compernolle; Yoram Rudy; Jos F M Smits; Willem Flameng; colleen clancy; Lieve Moons; Marc A Vos; Mieke Dewerchin; Klaus Benndorf; Désiré Collen; Edward Carmeliet; Peter Carmeliet
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.
Nature medicine 2001;7(9):1021-7.
2001: Peter Carmeliet
Biomedicine. Clotting factors build blood vessels.
Science (New York, N.Y.) 2001;293(5535):1602-4.
2001: Els Melis; Lieve Moons; Maria De Mol; Jean-Marc Herbert; Nigel Mackman; Désiré Collen; Peter Carmeliet; Mieke Dewerchin
Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development.
Biochemical and biophysical research communications 2001;286(3):580-6.
2001: C Holst-Hansen; J A Low; Ross W Stephens; M D Johnson; Peter Carmeliet; Thomas L Frandsen; Nils Brünner; R B Dickson
Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat.
Breast cancer research and treatment 2001;68(3):225-37.
2001: Peter Carmeliet; Aernout Luttun
The emerging role of the bone marrow-derived stem cells in (therapeutic) angiogenesis.
Thrombosis and haemostasis 2001;86(1):289-97.
2001: Edward B Brown; Robert B Campbell; Y Tsuzuki; L Xu; Peter Carmeliet; Dai Fukumura; Rakesh K Jain
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nature medicine 2001;7(7):864-8.
2001: Iiro Rajantie; Niklas Ekman; Kristina Iljin; Elena Arighi; Y Gunji; Juha-Pekka Kaukonen; Aarno Palotie; M Dewerchin; Peter Carmeliet; Kari Alitalo
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.
Molecular and cellular biology 2001;21(14):4647-55.
2001: Peter Carmeliet; Lieve Moons; Aernout Luttun; V Vincenti; Veerle Compernolle; Maria De Mol; Y Wu; Françoise Bono; Laetitia Devy; Heike Beck; Dimitri Scholz; Till Acker; T DiPalma; Mieke Dewerchin; Agnès Noel; Ingeborg Stalmans; A Barra; Silvia Blacher; Thierry VandenDriessche; A Ponten; Ulf Eriksson; Karl H Plate; Jean-Michel Foidart; Wolfgang Schaper; D S Charnock-Jones; Daniel J Hicklin; Jean-Marc Herbert; Désiré Collen; M Graziella Persico
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.
Nature medicine 2001;7(5):575-83.
2001: Yuval Dor; Todd D Camenisch; Ahuva Itin; G I Fishman; John A McDonald; Peter Carmeliet; Eli Keshet
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects.
Development (Cambridge, England) 2001;128(9):1531-8.
2001: M Levi; Lieve Moons; Ann Bouché; S D Shapiro; Désiré Collen; Peter Carmeliet
Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice.
Circulation 2001;103(15):2014-20.
2001: Vincent Lambert; Carine Munaut; Agnès Noël; Francis Frankenne; Khalid Bajou; Robert D Gerard; Peter Carmeliet; Marie-Paule Defresne; Jean-Michel Foidart; Jean-Marie Rakic
Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1021-7.
2001: Ananth Kadambi; Carla Mouta Carreira; CO Yun; Timothy P Padera; Dennis E J G J Dolmans; Peter Carmeliet; Dai Fukumura; Rakesh K Jain
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer research 2001;61(6):2404-8.
2001: Frederic Lluís; Josep Roma; Mònica Suelves; Maribel Parra; G Aniorte; E Gallardo; I Illa; L Rodríguez; S M Hughes; Peter Carmeliet; Manuel Roig; Pura Muñoz-Cánoves
Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo.
Blood 2001;97(6):1703-11.
2001: Khalid Bajou; Véronique Masson; Robert D Gerard; P M Schmitt; V Albert; Michael Praus; Leif R Lund; Thomas L Frandsen; Nils Brunner; K Dano; Norbert E Fusenig; UH Weidle; G Carmeliet; D Loskutoff; Désiré Collen; Peter Carmeliet; Jean-Michel Foidart; Agnès Noël
The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies.
The Journal of cell biology 2001;152(4):777-84.
2001: Edward M Conway; Désiré Collen; Peter Carmeliet
Molecular mechanisms of blood vessel growth.
Cardiovascular research 2001;49(3):507-21.
2001: Anne Angelillo-Scherrer; P de Frutos; C Aparicio; Els Melis; Pierre Savi; Florea Lupu; Jef Arnout; Mieke Dewerchin; Marc F Hoylaerts; J Herbert; Désiré Collen; B Dahlbäck; Peter Carmeliet
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.
Nature medicine 2001;7(2):215-21.
2001: Thomas L Frandsen; C Holst-Hansen; Boye Nielsen; Ib Jarle Christensen; J R Nyengaard; Peter Carmeliet; Nils Brünner
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.
Cancer research 2001;61(2):532-7.
2001: Olivier Nicole; Fabian Docagne; Carine Ali; I Margaill; Peter Carmeliet; E T MacKenzie; D Vivien; Alain Buisson
The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.
Nature medicine 2001;7(1):59-64.
2000: Y Tsuzuki; Dai Fukumura; B Oosthuyse; Chieko Koike; Peter Carmeliet; Rakesh K Jain
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer research 2000;60(22):6248-52.
2000: Peter Carmeliet; R K Jain
Angiogenesis in cancer and other diseases.
Nature 2000;407(6801):249-57.
2000: Esther Creemers; Jack P M Cleutjens; J Smits; Stephane Heymans; Lieve Moons; Désiré Collen; Mat Daemen; Peter Carmeliet
Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.
The American journal of pathology 2000;156(6):1865-73.
2000: Peter Carmeliet
Proteinases in cardiovascular aneurysms and rupture: targets for therapy?
The Journal of clinical investigation 2000;105(11):1519-20.
2000: Myriam Baes; Steven Huyghe; Peter Carmeliet; Peter E Declercq; Désiré Collen; Guy P Mannaerts; Paul P Van Veldhoven
Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids.
The Journal of biological chemistry 2000;275(21):16329-36.
2000: Peter Carmeliet; Désiré Collen
Molecular basis of angiogenesis. Role of VEGF and VE-cadherin.
Annals of the New York Academy of Sciences 2000;902():249-62; discussion 262-4.
2000: Peter Carmeliet
Mechanisms of angiogenesis and arteriogenesis.
Nature medicine 2000;6(4):389-95.
2000: Mieke Dewerchin; Z Liang; Lieve Moons; Peter Carmeliet; Francis J Castellino; Désiré Collen; Elliot D Rosen
Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice.
Thrombosis and haemostasis 2000;83(2):185-90.
2000: Peter Carmeliet; Désiré Collen
Transgenic mouse models in angiogenesis and cardiovascular disease.
The Journal of pathology 2000;190(3):387-405.
2000: Peter Carmeliet
Gene targeting and gene transfer to unravel the molecular basis of the formation and disorders of blood vessels.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2000;62(1):31-68.
1999: Annelii Ny; Göran Leonardsson; Anna-Carin Hägglund; Peter Hägglöf; V A Ploplis; Peter Carmeliet; Tor Ny
Ovulation in plasminogen-deficient mice.
Endocrinology 1999;140(11):5030-5.
1999: Stephane Heymans; Aernout Luttun; Dieter Nuyens; Gregor Theilmeier; Esther Creemers; Lieve Moons; G D Dyspersin; Jack P M Cleutjens; M Shipley; A Angellilo; M Levi; O Nübe; A Baker; Eli Keshet; Florea Lupu; Jean-Marc Herbert; Jos F M Smits; S D Shapiro; Myriam Baes; M Borgers; Désiré Collen; Mat J A P Daemen; Peter Carmeliet
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.
Nature medicine 1999;5(10):1135-42.
1999: Peter Carmeliet; Maria Grazia Lampugnani; Lieve Moons; Ferruccio Breviario; Veerle Compernolle; Françoise Bono; Giovanna Balconi; Raffaella Spagnuolo; B Oosthuyse; Mieke Dewerchin; Adriana Zanetti; A Angellilo; Virginie Mattot; Dieter Nuyens; Esther Lutgens; Frédéric Clotman; M C de Ruiter; A Gittenberger-de Groot; R Poelmann; Florea Lupu; Jean-Marc Herbert; Désiré Collen; Elisabetta Dejana
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
Cell 1999;98(2):147-57.
1999: Jonathan Erlich; Graham C Parry; Colleen Fearns; M Muller; Peter Carmeliet; Thomas Luther; Nigel Mackman
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8138-43.
1999: Edward M Conway; Saskia Pollefeyt; J Cornelissen; I DeBaere; Marta Steiner-Mosonyi; Jeffrey I Weitz; H Weiler-Guettler; Peter Carmeliet; Désiré Collen
Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development.
Blood 1999;93(10):3442-50.
1999: Nobuo Nagai; Maria De Mol; H Roger Lijnen; Peter Carmeliet; Désiré Collen
Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice.
Circulation 1999;99(18):2440-4.
1999: H Roger Lijnen; Florea Lupu; Lieve Moons; Peter Carmeliet; David Goulding; Désiré Collen
Temporal and topographic matrix metalloproteinase expression after vascular injury in mice.
Thrombosis and haemostasis 1999;81(5):799-807.
1999: Peter Carmeliet; Yin-Shan Ng; Dieter Nuyens; Gregor Theilmeier; Koen Brusselmans; I Cornelissen; E Ehler; V V Kakkar; Ingeborg Stalmans; Virginie Mattot; J C Perriard; Mieke Dewerchin; Willem Flameng; Andras Nagy; Florea Lupu; Lieve Moons; Désiré Collen; Patricia A D'Amore; David T Shima
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.
Nature medicine 1999;5(5):495-502.
1999: JC Chan; Peter Carmeliet; Lieve Moons; Elliot D Rosen; ZF Huang; George J Broze; Désiré Collen; Francis J Castellino
Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit.
The Journal of clinical investigation 1999;103(4):475-82.
1999: Peter Carmeliet; Désiré Collen
Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development.
Current topics in microbiology and immunology 1999;237():133-58.
1998: Lieve Moons; C Shi; V Ploplis; E Plow; E Haber; Désiré Collen; Peter Carmeliet
Reduced transplant arteriosclerosis in plasminogen-deficient mice.
The Journal of clinical investigation 1998;102(10):1788-97.
1998: LR Jalbert; Elliot D Rosen; Lieve Moons; JC Chan; Peter Carmeliet; Désiré Collen; Francis J Castellino
Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice.
The Journal of clinical investigation 1998;102(8):1481-8.
1998: Peter Carmeliet; Désiré Collen
Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system.
Thrombosis research 1998;91(6):255-85.
1998: David J Pinsky; Hui Liao; CA Lawson; Shi Fang Yan; J Chen; Peter Carmeliet; D J Loskutoff; David M Stern
Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.
The Journal of clinical investigation 1998;102(5):919-28.
1998: Khalid Bajou; Agnès Noël; Robert D Gerard; Véronique Masson; Nils Brunner; C Holst-Hansen; Mihaela Skobe; Norbert E Fusenig; Peter Carmeliet; Désiré Collen; Jean-Michel Foidart
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.
Nature medicine 1998;4(8):923-8.
1998: Peter Carmeliet; Yuval Dor; Jean-Marc Herbert; D Fukumura; Koen Brusselmans; Mieke Dewerchin; Michal Neeman; Françoise Bono; Rinat Abramovitch; P Maxwell; C J Koch; P Ratcliffe; Lieve Moons; R K Jain; Désiré Collen; E Keshert; E Keshet
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature 1998;394(6692):485-90.
1998: Peter Carmeliet; L Moons; Désiré Collen
Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis.
Cardiovascular research 1998;39(1):8-33.
1998: Z Liang; A Cooper; ME DeFord; Peter Carmeliet; Désiré Collen; Francis J Castellino; Elliot D Rosen
Cloning and characterization of a cDNA encoding murine coagulation factor X.
Thrombosis and haemostasis 1998;80(1):87-91.
1998: H Roger Lijnen; Berthe Van Hoef; Florea Lupu; Lieve Moons; Peter Carmeliet; Désiré Collen
Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(7):1035-45.
1998: Peter Carmeliet; Désiré Collen
Tissue factor.
The international journal of biochemistry & cell biology 1998;30(6):661-7.
1998: Peter Carmeliet; Désiré Collen
Vascular development and disorders: molecular analysis and pathogenic insights.
Kidney international 1998;53(6):1519-49.
1998: LR Jalbert; Elliot D Rosen; A Lissens; Peter Carmeliet; Désiré Collen; Francis J Castellino
Nucleotide structure and characterization of the murine gene encoding anticoagulant protein C.
Thrombosis and haemostasis 1998;79(2):310-6.
1998: Graham C Parry; Jonathan Erlich; Peter Carmeliet; Thomas Luther; Nigel Mackman
Low levels of tissue factor are compatible with development and hemostasis in mice.
The Journal of clinical investigation 1998;101(3):560-9.
1998: Peter Carmeliet; Lieve Moons; Mieke Dewerchin; S Rosenberg; Jean-Marc Herbert; Florea Lupu; Désiré Collen
Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice.
The Journal of cell biology 1998;140(1):233-45.
1997: Peter Carmeliet; Lieve Moons; Roger Lijnen; Myriam Baes; V Lemaître; P Tipping; Angela F Drew; Y Eeckhout; S Shapiro; Florea Lupu; Désiré Collen
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation.
Nature genetics 1997;17(4):439-44.
1997: Elliot D Rosen; JC Chan; E Idusogie; Frédéric Clotman; G Vlasuk; T Luther; LR Jalbert; S Albrecht; L Zhong; A Lissens; Luc Schoonjans; Lieve Moons; Désiré Collen; Francis J Castellino; Peter Carmeliet
Mice lacking factor VII develop normally but suffer fatal perinatal bleeding.
Nature 1997;390(6657):290-4.
1997: Peter Carmeliet; Lieve Moons; Roger Lijnen; Stefan Janssens; Florea Lupu; Désiré Collen; Robert D Gerard
Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice.
Circulation 1997;96(9):3180-91.
1997: Peter Carmeliet; Désiré Collen
Genetic analysis of blood vessel formation role of endothelial versus smooth muscle cells.
Trends in cardiovascular medicine 1997;7(8):271-81.
1997: Peter Carmeliet; Désiré Collen
Molecular analysis of blood vessel formation and disease.
The American journal of physiology 1997;273(5 Pt 2):H2091-104.
1997: Peter Carmeliet; Lieve Moons; Jean-Marc Herbert; James Crawley; Florea Lupu; Roger Lijnen; Désiré Collen
Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice.
Circulation research 1997;81(5):829-39.
1997: Myriam Baes; Pierre Gressens; Eveline Baumgart; Peter Carmeliet; Minne Casteels; Marc Fransen; Philippe Evrard; Dariush Fahimi; Peter E Declercq; Désiré Collen; Paul P Van Veldhoven; Guy P Mannaerts
A mouse model for Zellweger syndrome.
Nature genetics 1997;17(1):49-57.
1997: Peter Carmeliet; Jean Marie Stassen; I Van Vlaenderen; R S Meidell; Désiré Collen; Robert D Gerard
Adenovirus-mediated transfer of tissue-type plasminogen activator augments thrombolysis in tissue-type plasminogen activator-deficient and plasminogen activator inhibitor-1-overexpressing mice.
Blood 1997;90(4):1527-34.
1997: Peter Carmeliet; Lieve Moons; Mieke Dewerchin; Nigel Mackman; T Luther; Georg Breier; V Ploplis; M Müller; Andras Nagy; E Plow; Robert D Gerard; T Edgington; Werner Risau; Désiré Collen
Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system.
Annals of the New York Academy of Sciences 1997;811():191-206.
1997: Annelii Ny; L Nordström; Peter Carmeliet; Tor Ny
Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiency.
European journal of biochemistry / FEBS 1997;244(2):487-93.
1997: Peter Carmeliet; Lieve Moons; Jean Marie Stassen; Maria De Mol; Ann Bouché; Joost J van den Oord; Mark Kockx; Désiré Collen
Vascular wound healing and neointima formation induced by perivascular electric injury in mice.
The American journal of pathology 1997;150(2):761-76.
1997: Peter Carmeliet; Lieve Moons; V Ploplis; E Plow; Désiré Collen
Impaired arterial neointima formation in mice with disruption of the plasminogen gene.
The Journal of clinical investigation 1997;99(2):200-8.
1996: E Idusogie; Elliot D Rosen; Peter Carmeliet; Désiré Collen; Francis J Castellino
Nucleotide structure and characterization of the murine blood coagulation factor VII gene.
Thrombosis and haemostasis 1996;76(6):957-64.
1996: Peter Carmeliet; Désiré Collen
Genetic analysis of the plasminogen and coagulation system in mice.
Haemostasis 1996;26 Suppl 4():132-53.
1996: Peter Carmeliet; Nigel Mackman; Lieve Moons; Thomas Luther; P Gressens; I Van Vlaenderen; H Demunck; M Kasper; G Breier; P Evrard; M Müller; W Risau; T Edgington; Désiré Collen
Role of tissue factor in embryonic blood vessel development.
Nature 1996;383(6595):73-5.
1996: Y Y Huang; M E Bach; Hans-Peter Lipp; Min Zhuo; David P Wolfer; Robert D Hawkins; L Schoonjans; Eric R Kandel; J M Godfraind; R Mulligan; Désiré Collen; Peter Carmeliet
Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8699-704.
1996: H Roger Lijnen; Peter Carmeliet; A Bouché; Lieve Moons; VA Ploplis; Edward F Plow; Désiré Collen
Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.
Blood 1996;88(3):870-6.
1996: Thomas Luther; C Flössel; Nigel Mackman; Angelika Bierhaus; Michael Kasper; Sybille Albrecht; E Helene Sage; L Iruela-Arispe; H Grossmann; A Ströhlein; Youming Zhang; Peter P Nawroth; Peter Carmeliet; D J Loskutoff; M Müller
Tissue factor expression during human and mouse development.
The American journal of pathology 1996;149(1):101-13.
1996: Peter Carmeliet; Valerie Ferreira; G Breier; Saskia Pollefeyt; L Kieckens; Marina Gertsenstein; M Fahrig; A Vandenhoeck; K Harpal; C Eberhardt; C Declercq; J Pawling; Lieve Moons; Désiré Collen; W Risau; Andras Nagy
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele.
Nature 1996;380(6573):435-9.
1996: E Idusogie; E Rosen; J P Geng; Peter Carmeliet; Désiré Collen; Francis J Castellino
Characterization of a cDNA encoding murine coagulation factor VII.
Thrombosis and haemostasis 1996;75(3):481-7.
1996: Mieke Dewerchin; A V Nuffelen; G Wallays; A Bouché; Lieve Moons; Peter Carmeliet; R C Mulligan; Désiré Collen
Generation and characterization of urokinase receptor-deficient mice.
The Journal of clinical investigation 1996;97(3):870-8.
1996: Peter Carmeliet; Désiré Collen
Gene manipulation and transfer of the plasminogen and coagulation system in mice.
Seminars in thrombosis and hemostasis 1996;22(6):525-42.
1995: Göran Leonardsson; X R Peng; K Liu; L Nordström; Peter Carmeliet; R Mulligan; D Collen; T Ny
Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12446-50.
1995: VA Ploplis; Peter Carmeliet; S Vazirzadeh; I Van Vlaenderen; Lieve Moons; Edward F Plow; Désiré Collen
Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.
Circulation 1995;92(9):2585-93.
1995: Peter Carmeliet; Désiré Collen
Role of the plasminogen/plasmin system in thrombosis, hemostasis, restenosis and atherosclerosis evaluation in transgenic animals.
Trends in cardiovascular medicine 1995;5(4):117-22.
1995: Peter Carmeliet; Désiré Collen
Gene targeting and gene transfer studies of the biological role of the plasminogen/plasmin system.
Thrombosis and haemostasis 1995;74(1):429-36.
1995: Peter Carmeliet; A Bouché; C De Clercq; S Janssen; Saskia Pollefeyt; S Wyns; R C Mulligan; Désiré Collen
Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.
Annals of the New York Academy of Sciences 1995;748():367-81; discussion 381-2.
1994: Peter Carmeliet; R C Mulligan; Désiré Collen
Transgenic animals as tools for the study of fibrinolysis in vivo.
Journal of internal medicine 1994;236(4):455-9.
1994: Peter Carmeliet; L Schoonjans; L Kieckens; B Ream; J Degen; R Bronson; R De Vos; Joost J van den Oord; Désiré Collen; R C Mulligan
Physiological consequences of loss of plasminogen activator gene function in mice.
Nature 1994;368(6470):419-24.
1993: Peter Carmeliet; Jean Marie Stassen; L Schoonjans; B Ream; Joost J van den Oord; Maria De Mol; R C Mulligan; Désiré Collen
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.
The Journal of clinical investigation 1993;92(6):2756-60.
1993: Peter Carmeliet; L Kieckens; L Schoonjans; B Ream; A van Nuffelen; G Prendergast; M Cole; R Bronson; Désiré Collen; R C Mulligan
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.
The Journal of clinical investigation 1993;92(6):2746-55.
1991: Peter Carmeliet; Hugo Vankelecom; Jo Van Damme; An D Billiau; Carl Denef
Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin.
Neuroendocrinology 1991;53(1):29-34.
1990: Karl Bauer; Peter Carmeliet; M Schulz; Myriam Baes; Carl Denef
Regulation and cellular localization of the membrane-bound thyrotropin-releasing hormone-degrading enzyme in primary cultures of neuronal, glial and adenohypophyseal cells.
Endocrinology 1990;127(3):1224-33.
1990: W Allaerts; Peter Carmeliet; Carl Denef
New perspectives in the function of pituitary folliculo-stellate cells.
Molecular and cellular endocrinology 1990;71(2):73-81.
1990: Hugo Vankelecom; Peter Carmeliet; Hubertine Heremans; Jo Van Damme; R Dijkmans; An D Billiau; Carl Denef
Interferon-gamma inhibits stimulated adrenocorticotropin, prolactin, and growth hormone secretion in normal rat anterior pituitary cell cultures.
Endocrinology 1990;126(6):2919-26.
1989: Peter Carmeliet; P Maertens; Carl Denef
Stimulation and inhibition of prolactin release from rat pituitary lactotrophs by the cholinomimetic carbachol in vitro. Influence of hormonal environment and intercellular contacts.
Molecular and cellular endocrinology 1989;63(1-2):121-31.
1989: Peter Carmeliet; Myriam Baes; Carl Denef
The glucocorticoid hormone dexamethasone reverses the growth hormone-releasing properties of the cholinomimetic carbachol.
Endocrinology 1989;124(5):2625-34.
1989: Peter Carmeliet; Carl Denef
Synthesis and release of acetylcholine by normal and tumoral pituitary corticotrophs.
Endocrinology 1989;124(5):2218-27.
1989: Hugo Vankelecom; Peter Carmeliet; Jo Van Damme; An D Billiau; Carl Denef
Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system.
Neuroendocrinology 1989;49(1):102-6.
1989: Carl Denef; P Maertens; W Allaerts; A Mignon; W Robberecht; L Swennen; Peter Carmeliet
Cell-to-cell communication in peptide target cells of anterior pituitary.
Methods in enzymology 1989;168():47-71.
1988: Peter Carmeliet; Carl Denef
Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary.
Endocrinology 1988;123(2):1128-39.