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christophe biot

Research Profile

Chemicals & Drugs

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Publications

TOP 3
christophe biot; Faustine Dubar; Jamal Khalife; Christian Slomianny
Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes.
Emmanuel Curis; Faustine Dubar; Ioannis Nicolis; Simone Bénazeth; christophe biot
Statistical methodology for the detection of small changes in distances by EXAFS: application to the antimalarial ruthenoquine.
christophe biot; Laurent Fraisse; J Khalife; F Nosten; D Ter-Minassian; D Dive
The antimalarial ferroquine: from bench to clinic.

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All Publications

2012: christophe biot; Faustine Dubar; Jamal Khalife; Christian Slomianny
Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes.
Metallomics : integrated biometal science 2012;4(8):780-3.
2012: Emmanuel Curis; Faustine Dubar; Ioannis Nicolis; Simone Bénazeth; christophe biot
Statistical methodology for the detection of small changes in distances by EXAFS: application to the antimalarial ruthenoquine.
The journal of physical chemistry. A 2012;116(23):5577-85.
2011: christophe biot; Laurent Fraisse; J Khalife; F Nosten; D Ter-Minassian; D Dive
The antimalarial ferroquine: from bench to clinic.
Parasite (Paris, France) 2011;18(3):207-14.
2011: Faustine Dubar; Timothy J Egan; Bruno Pradines; David Kuter; Kanyile K Ncokazi; Delphine Forge; Jean-François Paul; Christine Pierrot; Hadidjatou Kalamou; Jamal Khalife; Eric Buisine; Christophe Rogier; Hervé Vezin; Isabelle Forfar; Christian Slomianny; Xavier Trivelli; Sergey Kapishnikov; Leslie Leiserowitz; Daniel Dive; christophe biot
The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance.
ACS chemical biology 2011;6(3):275-87.
2010: Rodrigo Arancibia; Faustine Dubar; Bruno Pradines; Isabelle Forfar; Daniel Dive; A Hugo Klahn; christophe biot
Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure.
Bioorganic & medicinal chemistry 2010;18(22):8085-91.
2009: Faustine Dubar; Guillaume Anquetin; Bruno Pradines; Daniel Dive; Jamal Khalife; christophe biot
Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach.
Journal of medicinal chemistry 2009;52(24):7954-7.
2009: Natascha Chavain; Elisabeth Davioud; Xavier Trivelli; Linda Mbeki; Matthias Rottmann; Reto Brun; christophe biot
Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker.
Bioorganic & medicinal chemistry 2009;17(23):8048-59.
2008: Natascha Chavain; Hervé Vezin; Daniel Dive; Nadia Touati; Jean-François Paul; Eric Buisine; christophe biot
Investigation of the redox behavior of ferroquine, a new antimalarial.
Molecular pharmaceutics 2008;5(5):710-6.
2008: Daniel Dive; christophe biot
Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial.
ChemMedChem 2008;3(3):383-91.
2008: Faustine Dubar; Jamal Khalife; Jacques Brocard; Daniel Dive; christophe biot
Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.
Molecules (Basel, Switzerland) 2008;13(11):2900-7.
2007: christophe biot; Bruno Pradines; Marie-Hélène Sergeant; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues.
Bioorganic & medicinal chemistry letters 2007;17(23):6434-8.
2006: Eric Buisine; Katherine A De Villiers; Timothy J Egan; christophe biot
Solvent-induced effects: self-association of positively charged pi systems.
Journal of the American Chemical Society 2006;128(37):12122-8.
2006: christophe biot; Wassim Daher; Cheikh M Ndiaye; Patricia Melnyk; Bruno Pradines; Natascha Chavain; Alain Pellet; Laurent Fraisse; Lydie Pelinski; Christian Jarry; Jacques Brocard; Jamal Khalife; Isabelle Forfar-Bares; Daniel Dive
Probing the role of the covalent linkage of ferrocene into a chloroquine template.
Journal of medicinal chemistry 2006;49(15):4707-14.
2006: christophe biot; Kelly Chibale
Novel approaches to antimalarial drug discovery.
Infectious disorders drug targets 2006;6(2):173-204.
2006: christophe biot; Wassim Daher; Natascha Chavain; Thierry Fandeur; Jamal Khalife; Daniel Dive; Erik De Clercq
Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.
Journal of medicinal chemistry 2006;49(9):2845-9.
2006: Wassim Daher; Lydie Pelinski; Sylvie Klieber; Freddy Sadoun; Viviane Meunier; Martine Bourrié; christophe biot; François Guillou; Gérard Fabre; Jacques Brocard; Laurent Fraisse; Jean-Pierre Maffrand; Jamal Khalife; Daniel Dive
In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):667-82.
2006: Dimitri Gilis; christophe biot; Eric Buisine; Yves Dehouck; Marianne Rooman
Development of novel statistical potentials describing cation-pi interactions in proteins and comparison with semiempirical and quantum chemistry approaches.
Journal of chemical information and modeling 2006;46(2):884-93.
2006: Wassim Daher; christophe biot; Thierry Fandeur; Hélène Jouin; Lydie Pelinski; Eric Viscogliosi; Laurent Fraisse; Bruno Pradines; Jacques Brocard; Jamal Khalife; Daniel Dive
Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.
Malaria journal 2006;5():11.
2005: christophe biot; Donatella Taramelli; Isabelle Forfar-Bares; Lucien A Maciejewski; Mlandzeni Boyce; Guy Nowogrocki; Jacques Brocard; Nicoletta Basilico; Piero Olliaro; Timothy J Egan
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.
Molecular pharmaceutics 2005;2(3):185-93.
2004: christophe biot; Holger Bauer; R Heiner Schirmer; Elisabeth Davioud
5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials.
Journal of medicinal chemistry 2004;47(24):5972-83.
2004: christophe biot; René Wintjens; Marianne Rooman
Stair motifs at protein-DNA interfaces: nonadditivity of H-bond, stacking, and cation-pi interactions.
Journal of the American Chemical Society 2004;126(20):6220-1.
2003: christophe biot; Eric Buisine; Marianne Rooman
Free-energy calculations of protein-ligand cation-pi and amino-pi interactions: from vacuum to proteinlike environments.
Journal of the American Chemical Society 2003;125(46):13988-94.
2003: Yves Dehouck; christophe biot; Dimitri Gilis; Jean Marc Kwasigroch; Marianne Rooman
Sequence-structure signals of 3D domain swapping in proteins.
Journal of molecular biology 2003;330(5):1215-25.
2003: christophe biot; Jean Dessolin; Philippe Grellier; Elisabeth Davioud
Double-drug development against antioxidant enzymes from Plasmodium falciparum.
Redox report : communications in free radical research 2003;8(5):280-3.
2002: Marianne Rooman; Yves Dehouck; Jean Marc Kwasigroch; christophe biot; Dimitri Gilis
What is paradoxical about Levinthal paradox?
Journal of biomolecular structure & dynamics 2002;20(3):327-9.
2002: christophe biot; Eric Buisine; Jean Marc Kwasigroch; René Wintjens; Marianne Rooman
Probing the energetic and structural role of amino acid/nucleobase cation-pi interactions in protein-ligand complexes.
The Journal of biological chemistry 2002;277(43):40816-22.
2002: Laurence Delhaes; christophe biot; Laurence Berry; Philippe Delcourt; Lucien A Maciejewski; Daniel Camus; Jacques Brocard; Daniel Dive
Synthesis of ferroquine enantiomers: first investigation of effects of metallocenic chirality upon antimalarial activity and cytotoxicity.
Chembiochem : a European journal of chemical biology 2002;3(5):418-23.
2001: Elisabeth Davioud; S Delarue; christophe biot; B Schwöbel; C C Boehme; A Müssigbrodt; Louis Maes; Christian Sergheraert; Philippe Grellier; R Heiner Schirmer; Katja Becker
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.
Journal of medicinal chemistry 2001;44(24):4268-76.
2001: Jean Dessolin; christophe biot; Elisabeth Davioud
Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives.
The Journal of organic chemistry 2001;66(16):5616-9.
2001: Laurence Delhaes; H Abessolo; christophe biot; Laurence Berry; Philippe Delcourt; Lucien A Maciejewski; Jacques Brocard; Daniel Camus; Daniel Dive
In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites.
Parasitology research 2001;87(3):239-44.
2000: christophe biot; Laurence Delhaes; Lucien A Maciejewski; M Mortuaire; Daniel Camus; Daniel Dive; Jacques Brocard
Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents.
European journal of medicinal chemistry 2000;35(7-8):707-14.
2000: christophe biot; Nadine François; Lucien A Maciejewski; Jacques Brocard; Daniel Poulain
Synthesis and antifungal activity of a ferrocene-fluconazole analogue.
Bioorganic & medicinal chemistry letters 2000;10(8):839-41.
1999: christophe biot; Laurence Delhaes; C M N'Diaye; Lucien A Maciejewski; Daniel Camus; Daniel Dive; Jacques Brocard
Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds.
Bioorganic & medicinal chemistry 1999;7(12):2843-7.
1998: Olivier DOMARLE; G Blampain; H Agnaniet; T Nzadiyabi; J Lebibi; Jacques Brocard; Lucien A Maciejewski; christophe biot; AJ Georges; P Millet
In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine.
Antimicrobial agents and chemotherapy 1998;42(3):540-4.
1997: christophe biot; G Glorian; Lucien A Maciejewski; Jacques Brocard
Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.
Journal of medicinal chemistry 1997;40(23):3715-8.