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Keduo Qian

Research Profile

Chemicals & Drugs

Living Beings

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Occupations

Drug Design

Anatomy

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Drug Screening Assays, Antitumor

Genes & Molecular Sequences

Molecular Structure

Physiology

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Publications

TOP 3
Wen-Qun Li; Ying-Qian Liu; Susan L Morris-Natschke; Keduo Qian; Jin Tian; Chih-Ya Wang; Xu-Li Wang; Liu Yang; Xing-Wen Zhou; Kuo-Hsiung Lee
Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.
Zhao Dang; Phong Ho; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Lei Zhu; Chin-Ho Chen
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.
Yingqian Liu; Keduo Qian; Chih-Ya Wang; Xiaoming Yang; Chin-Ho Chen; Kuo-Hsiung Lee
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.

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All Publications

2013: Wen-Qun Li; Ying-Qian Liu; Susan L Morris-Natschke; Keduo Qian; Jin Tian; Chih-Ya Wang; Xu-Li Wang; Liu Yang; Xing-Wen Zhou; Kuo-Hsiung Lee
Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.
Bioorganic & medicinal chemistry 2013;21(8):2363-9.
2013: Zhao Dang; Phong Ho; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Lei Zhu; Chin-Ho Chen
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.
Journal of medicinal chemistry 2013;56(5):2029-37.
2012: Yingqian Liu; Keduo Qian; Chih-Ya Wang; Xiaoming Yang; Chin-Ho Chen; Kuo-Hsiung Lee
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.
Bioorganic & medicinal chemistry letters 2012;22(24):7530-3.
2012: Xiao-Feng Wang; Pei-Chi Wu; Kenneth F Bastow; Mann-Jen Hour; Rong Huang; Hsin-Yi Hung; William P Janzen; Jian Jin; Kuo-Hsiung Lee; Yi-Nan Liu; Susan L Morris-Natschke; Emika Ohkoshi; Keduo Qian; Bingjie Qin; Xing-Tao Tian; Lan Xie
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.
Bioorganic & medicinal chemistry letters 2012;22(19):6224-8.
2012: Keduo Qian; Ibrahim D Bori; Chin-Ho Chen; Li Huang; Kuo-Hsiung Lee
Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.
Journal of medicinal chemistry 2012;55(18):8128-36.
2012: Lian-Qi Sun; Lei Zhu; Chin Ho Chen; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Bingjie Qin; Lan Xie
Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.
Journal of medicinal chemistry 2012;55(16):7219-29.
2012: Zhao Dang; Phong Ho; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Lei Zhu; Chin-Ho Chen
Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.
Bioorganic & medicinal chemistry letters 2012;22(16):5190-4.
2012: Hsin-Yi Hung; Susan L Morris-Natschke; Keduo Qian; Chau-Shin Hsu; Kuo-Hsiung Lee
Recent discovery of plant-derived anti-diabetic natural products.
Natural product reports 2012;29(5):580-606.
2012: Lian-Qi Sun; Chin-Ho Chen; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Bingjie Qin; Lan Xie
Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(7):2376-9.
2012: Ying Chen; Ming Cheng; Chin-Yu Lai; Hong-Rui Liu; Hong-Shan Liu; Susan L Morris-Natschke; Keduo Qian; Pei-Chi Wu; Peng Xia; Yi Xia; Zheng-Yu Yang; Kuo-Hsiung Lee
Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents.
European journal of medicinal chemistry 2012;49():74-85.
2012: M Vijaya Bhaskar Reddy; Kenneth F Bastow; Kuo-Hsiung Lee; Emika Ohkoshi; Keduo Qian; Yuh-Chiang Shen; Tian-Shung Wu
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.
European journal of medicinal chemistry 2012;47(1):97-103.
2011: M Vijaya Bhaskar Reddy; Kuo-Hsiung Lee; Keduo Qian; Wei-Jern Tsai; Tian-Shung Wu
Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation.
Bioorganic & medicinal chemistry 2011;19(24):7711-9.
2011: Hong-Shan Liu; Susan L Morris-Natschke; Keduo Qian; Peng Xia; Yi Xia; Shi-Qing Xu; Zheng-Yu Yang; Chin-Ho Chen; Ying Chen; Ming Cheng; Kuo-Hsiung Lee
Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2011;21(19):5831-4.
2011: Ying Chen; Ming Cheng; Chin-Ho Chen; Fa-Qiang Liu; Susan L Morris-Natschke; Keduo Qian; Peng Xia; Yi Xia; Zheng-Yu Yang; Donglei Yu; Kuo-Hsiung Lee
Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues.
European journal of medicinal chemistry 2011;46(10):4924-36.
2011: Keduo Qian; Chin-Ho Chen; Li Huang; Hsin-Yi Hung; Sang-Yong Kim; Kuo-Hsiung Lee
New betulinic acid derivatives as potent proteasome inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(19):5944-7.
2011: Qiang Wang; Shuyang Wang; Chin-Ho Chen; Xiaohe Guo; Weidong Hu; Kuo-Hsiung Lee; Zhenliang Pan; Keduo Qian; Le Tao; Junbiao Chang
Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.
European journal of medicinal chemistry 2011;46(9):4178-83.
2011: Hsiu-Hui Chan; Tsong-Long Hwang; Mopur Vijaya Bhaskar Reddy; Ding-Tzai Li; Keduo Qian; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.
Journal of natural products 2011;74(4):796-802.
2011: M Vijaya Bhaskar Reddy; Yuh-Chiang Shen; Jai-Sing Yang; Tsong-Long Hwang; Kenneth F Bastow; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu
New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.
Bioorganic & medicinal chemistry 2011;19(6):1895-906.
2011: Mei-Lin Yang; Ping-Chung Kuo; Tsann-Long Hwang; Wen-Fei Chiou; Keduo Qian; Chin-Yu Lai; Kuo-Hsiung Lee; Tian-Shung Wu
Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives.
Bioorganic & medicinal chemistry 2011;19(5):1674-82.
2011: Pu Zhang; Li Xu; Keduo Qian; Jun Liu; Luyong Zhang; Kuo-Hsiung Lee; Hongbin Sun
Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.
Bioorganic & medicinal chemistry letters 2011;21(1):338-41.
2011: Li-Shian Shi; Chih-Hua Chao; De-Yang Shen; Hsiu-Hui Chan; Chou-Hsiung Chen; Yu-Ren Liao; Shwu-Jen Wu; Yann-Lii Leu; Yuh-Chiang Shen; Yao-Haur Kuo; E-Jian Lee; Keduo Qian; Tian-Shung Wu; Kuo-Hsiung Lee
Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.
Bioorganic & medicinal chemistry 2011;19(1):677-83.
2010: Shwu-Jen Wu; Yann-Lii Leu; Chou-Hsiung Chen; Chih-Hua Chao; De-Yang Shen; Hsiu-Hui Chan; E-Jian Lee; Tian-Shung Wu; Yea-Hwey Wang; Yuh-Chiang Shen; Keduo Qian; Kenneth F Bastow; Kuo-Hsiung Lee
Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.
Journal of natural products 2010;73(11):1756-62.
2010: Li-Chen Chou; Meng-Tung Tsai; Mei-Hua Hsu; Sheng-Hung Wang; Tzong-Der Way; Chi-Hung Huang; Hui-Yi Lin; Keduo Qian; Yizhou Dong; Kuo-Hsiung Lee; Li-Jiau Huang; Sheng-Chu Kuo
Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.
Journal of medicinal chemistry 2010;53(22):8047-58.
2010: Shi-Qing Xu; Xin Yan; Ying Chen; Peng Xia; Keduo Qian; Donglei Yu; Yi Xia; Zheng-Yu Yang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.
Bioorganic & medicinal chemistry 2010;18(20):7203-11.
2010: Juan Xiong; Yoshiki Kashiwada; Chin-Ho Chen; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yoshihisa Takaishi
Conjugates of betulin derivatives with AZT as potent anti-HIV agents.
Bioorganic & medicinal chemistry 2010;18(17):6451-69.
2010: Qiang Wang; Yanfeng Li; Chuanjun Song; Keduo Qian; Chin-Ho Chen; Kuo-Hsiung Lee; Junbiao Chang
Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs.
Bioorganic & medicinal chemistry letters 2010;20(14):4053-6.
2010: Bingjie Qin; Xingkai Jiang; Hong Lu; Xingtao Tian; Florent Barbault; Li Huang; Keduo Qian; Chin-Ho Chen; Rong Huang; Shibo Jiang; Kuo-Hsiung Lee; Lan Xie
Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2010;53(13):4906-16.
2010: Jian Tang; Keduo Qian; Bei Na Zhang; Ying Chen; Peng Xia; Donglei Yu; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents.
Bioorganic & medicinal chemistry 2010;18(12):4363-73.
2010: Keduo Qian; Reen-Yun Kuo; Chin-Ho Chen; Li Huang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.
Journal of medicinal chemistry 2010;53(8):3133-41.
2010: Song-Lin Li; Jing-Zheng Song; Chun-Feng Qiao; Yan Zhou; Keduo Qian; Kuo-Hsiung Lee; Hong Xi XU
A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis.
Journal of pharmaceutical and biomedical analysis 2010;51(4):812-23.
2010: Jiawang Liu; Ming Zhao; Keduo Qian; Xiaoyi Zhang; Kuo-Hsiung Lee; Jianhui Wu; Yi-Nan Liu; Shiqi Peng
Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis.
Bioorganic & medicinal chemistry 2010;18(5):1910-7.
2010: Li-Chen Chou; Chien-Ting Chen; Jang-Chang Lee; Tzong-Der Way; Chi-Hung Huang; Shih-Ming Huang; Che-Ming Teng; Takao Yamori; Tian-Shung Wu; Chung-Ming Sun; Du-Shieng Chien; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Li-Jiau Huang; Sheng-Chu Kuo
Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.
Journal of medicinal chemistry 2010;53(4):1616-26.
2009: Zhao Dang; Weihong Lai; Keduo Qian; Phong Ho; Kuo-Hsiung Lee; Chin-Ho Chen; Li Huang
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.
Journal of medicinal chemistry 2009;52(23):7887-91.
2009: Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.
Natural product reports 2009;26(10):1321-44.
2009: Jianhui Wu; Ming Zhao; Keduo Qian; Kuo-Hsiung Lee; Susan L Morris-Natschke; Shiqi Peng
Novel N-(3-carboxyl-9-benzyl-beta-carboline-1-yl)ethylamino acids: synthesis, anti-tumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation.
European journal of medicinal chemistry 2009;44(10):4153-61.
2009: Fei Huang; Ming Zhao; Xiaoyi Zhang; Chao Wang; Keduo Qian; Reen-Yen Kuo; Susan L Morris-Natschke; Kuo-Hsiung Lee; Shiqi Peng
Synthesis, DNA intercalation and 3D QSAR analysis of cis-2,4,5-trisubstituted-1,3-dithiolanes as a novel class of antitumor agents.
Bioorganic & medicinal chemistry 2009;17(16):6085-95.
2009: Yu-Hsun Chang; Mei-Hua Hsu; Sheng-Hung Wang; Li-Jiau Huang; Keduo Qian; Susan L Morris-Natschke; Ernest Hamel; Sheng-Chu Kuo; Kuo-Hsiung Lee
Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.
Journal of medicinal chemistry 2009;52(15):4883-91.
2009: Keduo Qian; Donglei Yu; Chin-Ho Chen; Li Huang; Susan L Morris-Natschke; Theodore J Nitz; Karl Salzwedel; Mary Reddick; Graham P Allaway; Kuo-Hsiung Lee
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.
Journal of medicinal chemistry 2009;52(10):3248-58.
2009: Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
HIV entry inhibitors and their potential in HIV therapy.
Medicinal research reviews 2009;29(2):369-93.
2008: Lan Xie; Huan-Fang Guo; Hong Lu; Xiao-Mei Zhuang; An-Ming Zhang; Gang Wu; Jin-Xiu Ruan; Ting Zhou; Donglei Yu; Keduo Qian; Kuo-Hsiung Lee; Shibo Jiang
Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).
Journal of medicinal chemistry 2008;51(24):7689-96.
2008: Li Huang; Donglei Yu; Phong Ho; Keduo Qian; Kuo-Hsiung Lee; Chin-Ho Chen
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.
Bioorganic & medicinal chemistry 2008;16(14):6696-701.
2008: Yu Chen; Guohui Cui; Ming Zhao; Chao Wang; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Shiqi Peng
Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu.
Bioorganic & medicinal chemistry 2008;16(11):5914-25.
2008: An-Shen Lin; Keduo Qian; Yoshihide Usami; Li Lin; Hideji Itokawa; Charleson Hsu; Susan L Morris-Natschke; Kuo-Hsiung Lee
5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix.
Journal of natural medicines 2008;62(2):164-7.
2007: Keduo Qian; Kyoko Goto; Donglei Yu; Susan L Morris-Natschke; Theodore J Nitz; Nicole Kilgore; Graham P Allaway; Kuo-Hsiung Lee
Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.
Bioorganic & medicinal chemistry letters 2007;17(23):6553-7.